Abstract: This brain function measurement device (100) includes a brain blood flow information acquisition unit (1) that acquires brain blood flow information (d1) of a subject (P), a brain function information acquisition unit (30) that acquires brain function correlation information (d3) indicating a relative change in a correlation between respective portions of the brain acquired on the basis of the brain blood flow information measured in a plurality of portions of a brain before and after a task is presented, and a brain function image generation unit (7) that generates a first brain function image (20) in which a relative position of each measurement position (23) for the brain blood flow information and the measurement position at which the correlation acquired on the basis of the brain function correlation information has changed are visually recognizable.

Abstract: A device, system and method for vibration sensitivity assessment are provided. the device has an attachment portion configured to detachably connect the device to a programmable vibration source and a probe configured to be applied to a test location on a test subject's skin and to convey vibrations generated by the programmable vibration source to the test location. The programmable vibration source may for example be a mobile telephone. A low-cost and widely usable device for vibration sensitivity assessment is thus provided.

Abstract: A system and apparatus for detecting diseases that combines biosensors and skin imaging. The system and apparatus combines bio-sensing technology for measuring volatile organic compounds (VOCs) emanating from the breath, oral cavity, and/or skin with multispectral high-resolution imaging of the skin utilizing visible and infrared wavelengths to detect specific diseases and/or medical conditions.

Abstract: A system for capturing, storing and comparing dermatological images includes two components, namely, a handheld exam control and a patient interface. The handheld exam control includes a camera, display screen, illuminator and a position sensor. The patient interface includes a patient position template and a position sensor interface. The system captures an image sequence and the precise location of each image. Images may be compared to previous images by a clinician.

Abstract: An exemplary tissue detection and location identification apparatus can include, for example, a first electrically conductive layer at least partially (e.g., circumferentially) surrounding a lumen, an insulating layer at least partially (e.g., circumferentially) surrounding the first electrically conductive layer, and a second electrically conductive layer circumferentially surrounding the insulating layer, where the insulating layer can electrically isolate the first electrically conductive layer from the second electrically conductive layer. A further insulating layer can be included which can at least partially surrounding the second electrically conductive layer.

Abstract: A catheter device for crossing occlusions includes an elongate body, a central lumen extending within the elongate body from the proximal end to the distal end, a rotatable tip at the distal end of the elongate body, and an OCT imaging sensor. The rotatable tip is configured to rotate relative to the elongate body. The OCT imaging sensor includes an optical fiber coupled with the rotatable tip and configured to rotate therewith. A distal end of the elongate body includes one or more markers configured to occlude the OCT imaging sensor as it rotates. A fixed jog in the elongate body proximal to the distal end of the catheter positions the distal end of the catheter at an angle relative to the region of the catheter proximal to the fixed jog and is aligned with the one or more markers on the elongate body.

Abstract: A photoacoustic probe head (200a, 200b) is disclosed. The probe head (200a, 200b) comprises: a Fabry Perot acoustic sensor (202), an interrogation interface (A), an excitation input (B) and a two-axis mirror (204). The Fabry Perot acoustic sensor (200a, 200b) is operable to reflect an optical interrogation beam to create a reflected interrogation beam and to modulate the reflected interrogation beam in response to an acoustic signal at the acoustic sensor (202). The interrogation interface (A) is configured to receive an interrogation beam, and to receive the reflected interrogation beam from the acoustic sensor (202). The excitation input (B) is configured to receive an excitation beam for generating an acoustic field in a sample adjacent to the acoustic sensor (202). The two axis mirror (240) is configured to scan the interrogation beam between different locations of the acoustic sensor (202).

Abstract: An apparatus acquires signals from thermal sensors on a probe and performs a first interpolation or a first extrapolation between temperatures determined from the signals based on the spatial locations of the thermal sensors to produce a temperature spatial distribution map, determines there is at least one malfunctioning thermal sensor, and assigns the malfunctioning thermal sensors a first arbitrary temperature and the correctly operating thermal sensors a second arbitrary temperature.

Abstract: A biomedical signal sensing device includes a frame, a first carrier, and a sensing module. The frame includes a base, a first adjusting arm, and a second adjusting arm connecting to the base through the first adjusting arm. The first carrier is disposed on the base and includes first and second grooves. The sensing module is connected to the first adjusting arm through the second adjusting arm. The sensing module includes a second carrier connected to the second adjusting arm, and a pressure sensor disposed on the second carrier, in which the pressure sensor faces towards the first groove or the second groove. The first groove and the second groove extend along a first direction, the second adjusting arm extends along a second direction, the first adjusting arm extends along a third direction, and the first direction, the second direction, and the third direction are perpendicular to each other.

Abstract: Devices, systems, and methods herein relate to non-invasive cardiac monitoring of a cardiac parameter such as blood pressure. These systems and methods may receive and process user and cohort cardiac data to generate mechanical cardiac parameter values used to estimate blood pressure. In some variations, a method may include the steps of receiving mechanical cardiac data of a user measured using an accelerometer. A mechanical cardiac parameter value for a first time period and a second time period may be generated from the mechanical cardiac data. The blood pressure of the user may be estimated based on a change in the mechanical cardiac parameter value between the first and second time periods.

Abstract: Systems and methods to determine a composite respiratory vibration of a patient are disclosed, including a signal receiver circuit configured to receive physiologic information cyclic with patient respiration and vibration information indicative of patient respiratory vibrations for a plurality of respiratory cycles of a patient, and an assessment circuit configured to identify a first set of respiratory cycles of the plurality of respiratory cycles having a duration within a threshold, align segments of the vibration information corresponding to the first set of respiratory cycles, the segments associated with a desired portion of the respiratory cycle using a feature of the respiratory cycle, and determine the composite respiratory vibration using the aligned segments.

Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

Abstract: A method and apparatus of automatically locating in an image of a blood vessel the lumen boundary at a position in the vessel and from that measuring the diameter of the vessel. From the diameter of the vessel and estimated blood flow rate, a number of clinically significant physiological parameters are then determined and various user displays of interest generated. One use of these images and parameters is to aid the clinician in the placement of a stent. The system, in one embodiment, uses these measurements to allow the clinician to simulate the placement of a stent and to determine the effect of the placement. In addition, from these patient parameters various patient treatments are then performed.

Abstract: The invention presents an apparatus (6) for characterization of a condition of a vessel (12) wall of a living being (2). The relationship between temporal blood pressure (621) and blood flow (622) measurements of pulsatile blood motion within the vessel (12) is an indication of the health of the vessel (12) wall. Furthermore, the invention discloses a system (1) comprising the apparatus (6), and a method (100) of characterizing the condition of vessel (12) walls.

Abstract: Embodiments of the present disclosure provide an implantable device for monitoring properties of cerebrospinal fluid of a patient. In one embodiment, the device may include a housing, a processor, a support member, one or more sensors, and a data storage. The sensors may be in communication with the processor and configured to detect one or more properties of cerebrospinal fluid. The device may be configured for transmitting the data and receiving instructions by an operator for the delivery of a therapeutic agent or imaging agent from a reservoir disposed within the housing in operable communication with a pump.

Abstract: Exemplary diagnostic systems and methods involve delivering multispectral light to a tissue of a patient, detecting light from the tissue, and analyzing the tissue based on the detected light. Light delivery can be achieved using a multi-dispersion element monochromator apparatus that includes a broad spectrum light source, a rotating body, and multiple dispersion elements in operative association with the rotating body.

Abstract: The present disclosure relates to a method for determining a blood pressure value of a patient. The method comprises a step of determining a pulse course of the patient; a step of determining a reference point in the pulse course within a transition area from systole to diastole of a cardiac cycle of the patient; and a step of determining the blood pressure value based on the determined reference point.

Abstract: A blood pressure monitoring device, including a cuff assembly to connect around a limb of a user, a blood pressure monitor assembly disposed at a first side on at least a portion of the cuff assembly to detect at least one of a blood pressure level and a heart rate of the user, and a tourniquet assembly disposed on at least a portion of a second side of the blood pressure monitor assembly to at least partially decrease a diameter the tourniquet assembly around the limb of the user in a first position and at least partially increase the diameter of the tourniquet assembly around the limb of the user in a second position.

Abstract: The invention provides an intravenous (IV) dressing system that helps secure an IV catheter to a patient while simultaneously using embedded peripheral venous pressure (PVP), impedance, temperature, optical, and motion sensors to characterize properties of the IV system (e.g., infiltration, extravasation, occlusion) and the patient's physiological parameters (e.g., heart rate, SpO2, respiration rate, temperature, and blood pressure). Notably, the system converts PVP waveforms into arterial BP values (e.g., systolic and diastolic blood pressure).

Abstract: A sheet member is to form a bladder. A tubular member is to form a ventilation channel communicating with the bladder. A welded portion at which the sheet member and the tubular member are welded extends along a longitudinal direction of the tubular member over an entire circumference of the tubular member.

Abstract: A medical apparatus includes a probe configured for insertion into a body of a patient. The probe includes electrodes configured to contact tissue of a region within the body. The apparatus further includes a display screen a position-tracking system, and a processor. The processor is configured to acquire electrophysiological signals from the electrodes, to extract electrophysiological parameters from the signals, to compute a measure of consistency of the electrophysiological parameters at each of the locations with respect to a weighted median of the parameters extracted at neighboring locations, and to render to the display screen a map of the tissue while overlaying on the map a visual indication of the extracted electrophysiological parameters for which the measure of consistency satisfied a predefined consistency criterion, and automatically omitting from the map the electrophysiological parameters for which the measure of consistency did not satisfy the criterion.

Abstract: Systems and methods are provided for detecting and analyzing changes in a body. A system includes an electric field generator, an external sensor device, a quadrature demodulator, and a controller. The electric field generator is configured to generate an electric field that associates with a body. The external sensor device sends information to the electric field generator and is configured to detect a physical change in the body in the electric field, where the physical change causes a frequency change of the electric field. The quadrature demodulator receives the electric field from the electric field generator and is configured to detect the frequency change of the electric field and to produce a detected response. The controller, coupled to the electric field generator, is configured to output a frequency control signal to the electric field generator and to modify the frequency of the electric field by adjusting the frequency control signal.

Abstract: A passive MRI enhancing embodiment includes a plurality of resonators and increases signal-to-noise ratio of radiofrequency signals emitted by a specimen and captured by an MRI machine. The apparatus increases the magnetic field component of radiofrequency energy during signal transmission from the MRI machine to the specimen, and/or reception of signals from the specimen to the MRI machine. Use of the apparatus improves the images generated by the MRI machine, and/or reduces the time necessary for the MRI machine to capture the image. An isolator embodiment has a nonlinear resonator controllably configurable alternately into an isolation configuration and a transmission configuration, and a second resonator.

Abstract: The invention relates to a method for determining ischemic status. The method comprises acquiring magnetic resonance diffusion tensor matrices and obtaining a relative decrease of diffusion magnitude due to the ischemic status from the magnetic resonance diffusion tensor matrices. The invention also relates to a method for assessing stroke onset time. The method comprises acquiring magnetic resonance diffusion tensor matrices and obtaining a relative decrease of pure anisotropy due to stroke from the magnetic resonance diffusion tensor matrices.

Abstract: A bioimpedance measurement device and an operation method thereof are disclosed. The disclosed bioimpedance measurement device comprises: a body part which accommodates a measurement circuit and comprises a grip that can be gripped by a hand; a first electrode and a second electrode which are coupled to a first shaft provided on one side of the body part and rotate about the first shaft; and a third electrode and a fourth electrode which are coupled to a second shaft provided on the one side of the body part at a position different from that of the first shaft. When a subject to be measured is surrounded by and comes into contact with the first electrode, the second electrode, the third electrode, and the fourth electrode, the bioimpedance of the subject to be measured is measured.

Abstract: A catheter is presented herein which includes inductive coils which conform to the curved surface of a tubular catheter body and collectively can function as a three axis sensor during an intravascular and/or intracardiac treatment. The inductive coils can be fabricated on a flexible circuit substrate and affixed to the tubular catheter body. The catheter can include a distal portion that can be moved into a circular shape (“lasso”) when within vasculature or the heart. The inductive coils can be positioned around the circular shape such that a position and orientation of the distal portion can be determined in three dimensions when the distal portion is within a known fluctuating magnetic field.

Abstract: A bacterial and microorganism detector apparatus and system to provide quick and efficient sampling of a patient, or an attendee at an event, that allows for a canine or other animal to test the breath to determine the existence and presence of any deleterious particles, that may be present therein. The apparatus includes an intake device, in which the party breathes into an air drawing device such as a spirometer, or fan, a reservoir for collecting the sampled breath, a discard valve in the event that excessive breath has been taken in, an overflow valve from the reservoir, which then subjects the final segment of breath to filtration, which the animal can sniff for detection purposes, just before the remaining sample is discharged from the apparatus. The spirometer functions to withdraw air from the lungs of the treated party, for the sampling and testing purposes.

Abstract: A method for diagnosing a subject with one or more of hepatocellular carcinoma (HCC), chronic liver disease, colorectal liver metastases (CRLM), and pulmonary hypertension is described. The method includes obtaining a breath sample from a subject, analyzing the breath sample obtained from the subject to determine one or more breath metabolite abundance values, inputting one or more of the breath metabolite abundance values into a machine-learning-model, and assigning a clinical parameter to the subject representing the likelihood that the subject has one or more of HCC, chronic liver disease, CRLM, and pulmonary hypertension.

Abstract: Various embodiments relate to a method for estimating a breathing rate, including: receiving a plurality of channel state information (CSI) from a wireless device; selecting an initial reference CSI from the plurality of CSI; computing a perturbation index using the initial reference CSI and a portion of the plurality of CSI; determining an optimal reference CSI based upon the perturbation index; re-computing the perturbation index using the optimal reference CSI on a portion of the plurality of CSI subsequent to the optimal reference CSI; and determining a breathing rate from the perturbation index using a frequency analysis of the perturbation index.

Abstract: Systems and methods for detecting medically related events at a point of sale are disclosed herein. An example method of detecting droplets associated with a sneeze or cough at a point of sale includes: capturing, by an image sensor associated with a checkout workstation, one or more images; analyzing, by one or more processors, the images captured by the image sensor associated with the checkout workstation, to detect an indication that one or more droplets associated with a sneeze or cough are present upon one or more equipment associated with the checkout workstation; and triggering, by the one or more processors, a disinfection of the checkout workstation responsive to detecting the indication that the one or more droplets associated with the sneeze or cough are present upon the one or more equipment associated with the checkout workstation.

Abstract: A processor and method for deriving a respiratory signal is based on processing a 3-axis acceleration signal. A gravity vector is isolated from the 3-axis acceleration signal and a coordinate transformation is performed into a transformed 3-axis coordinate system in which the isolated average gravity vector is aligned with a first axis of the transformed 3-axis coordinate system. Analysis is then performed only of the components for the remaining two axes of the transformed 3-axis coordinate system, thereby to derive a 1 dimensional respiratory signal. A respiration rate may for example be obtained from the 1 dimensional respiratory signal using frequency analysis, or sleep disordered breathing events may be identified.

Abstract: Systems and methods to are disclosed to determine a sleep disordered breathing parameter of a patient, including receiving respiration information of the patient and temperature information of the patient and to determine the sleep disordered breathing parameter of the patient using the received respiration information and temperature information of the patient.

Abstract: A foot mounted wearable device is disclosed. The device includes a toe-ring which includes a plurality of sensors configured to sense motion data associated with a foot of a user. The toe-ring also includes a microcontroller which includes a motion information processing subsystem configured to process the sensed motion data acquired from the plurality of sensors to determine motion information associated with the user. The device also includes a motion information analysis subsystem configured to receive the motion information associated with the user via an established communication network. The motion information analysis subsystem is also configured to analyse received motion information associated with the user to derive knowledge of at least one function associated with the user, wherein the at least one function includes at least one of gesture recognition, steps tracking of the user or a combination thereof.

Abstract: The exemplified methods and systems (e.g., machine-learned systems) facilitate the acquisition of ballistocardiographic signals and the determination and use of ballistocardiographic signal related features, or parameters, in a model or classifier to estimate metrics associated with the physiological state of a subject, including for the presence or non-presence of a disease, medical condition, or indication of either. The estimated metric may be used to assist a physician or other healthcare provider in diagnosing the presence or non-presence and/or severity and/or localization of diseases, medical condition, or indication of either or in the treatment of said diseases or indicating conditions. In some embodiments, certain ballistocardiographic signals can also be used to remove motion artifacts from biophysical signals used for the estimation.

Abstract: A smart monitoring system comprising a plurality of sensor devices within a home or facility, at least one of the plurality of sensor devices comprising sensor elements configured to detect activity of an individual in the home or facility, and a computing device configured to receive activity signals from the plurality of sensor devices associated with the individual from the home or facility, parse the activity signals into scoring components by correlating the plurality of sensor devices to the scoring components, the scoring components including a sleep score, a motion score, and an event score, compute a current scoring of the individual based on the scoring components, compare the current scoring of the individual to historic scoring and peer scoring, generate a quality of life score for the individual based on the based on the comparison, and process a clinical analysis of the individual based on the quality of life score, the clinical analysis including graphical representations of the quality of life

Abstract: Embodiments are disclosed for estimating caloric expenditure based on center of mass motion and heart rate. In an embodiment, a method comprises: obtaining acceleration and rotation rate of a wearable device worn on a limb of a user; transforming the acceleration and rotation rate into an inertial frame; determining a vertical component of acceleration, rotation rate magnitude and vertical component of rotational acceleration due to limb rotation; determining a work rate (WR) based caloric expenditure based on the vertical component of acceleration, rotation rate magnitude and a correlation coefficient that measures a correlation between the vertical component of acceleration and the vertical component of rotational acceleration; obtaining heart rate (HR) data from a heart rate sensor of the wearable device; determining an HR based caloric expenditure based on the HR data; and fusing, the WR based caloric expenditure with the HR based caloric expenditure to get a fused caloric expenditure.

Abstract: A measurement apparatus is equipped with a processor. The processor acquires first velocity data, which is data on a velocity in a first direction, and second velocity data, which is data on a velocity in a second direction orthogonal to the first direction, on the basis of accelerations acquired at an acceleration sensor. The processor calculates a first coefficient on the basis of the acquired first velocity data and the acquired second velocity data. The processor determines whether the measurement apparatus is installed in normal orientation on the basis of the calculated first coefficient.

Abstract: The present disclosure includes systems and methods for deriving certain characteristics of the patient's body related to motion from captured motion data. The characteristics may be used to compare the characteristics of the supposed injury to the characteristics of a normally functioning body part as well as the functions of an injured body part. The present disclosure provides a reliable and reproducible way to determine whether a supposed injury is a feigned or exaggerated injury or an actual injury.

Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.

Abstract: Methods and system of using a target-binding aptasensor to determine a concentration of a target in a media may include dispensing target in the media, applying an intermittent pulse amperometry (“IPA”) waveform to the target-binding aptasensor in the media to sense the target, determining a reference point of the target-binding aptasensor to set a baseline level corresponding to the reference point, and determining the concentration of the target in the media based on the baseline level of the reference point.

Abstract: A soft conductive composite composition can include a soft matrix containing a conductive member that is associated with a bioactive component. The soft matrix can be formed from a silicone composition. The conductive member can be carbon nanotubes in the silicone composition. The carbon nanotubes can have at least two walls and be conductive. Also, the carbon nanotubes can be a mixture of functionalized carbon nanotubes and non-functionalized carbon nanotubes, which mixture can have a ratio of 1:2 to 1:20 w/w of functionalized to non-functionalized carbon nanotubes per gram of the silicone composition. The bioactive component (e.g., enzyme) can be associated with at least a first portion of the carbon nanotubes. A second portion of the carbon nanotubes can be devoid of the bioactive component.

Abstract: Present implementations can include a method of forming an implantable biochemical sensor, by coating a first substrate with a first solution, etching, by a laser, the first substrate to form one or more electrodes in the first substrate, coating a first face of the electrodes with an elastomer solution, coating a second face of the electrodes with the elastomer solution, solidifying the elastomer coating into an elastomer shell at least partially surrounding the electrodes, and removing at least a portion of the elastomer shell to form implantable electrodes.

Abstract: A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

Abstract: A diagnostic Electrochemical Impedance Spectroscopy (EIS) procedure is applied to measure values of impedance-related parameters for one or more sensing electrodes. The parameters may include real impedance, imaginary impedance, impedance magnitude, and/or phase angle. The measured values of the impedance-related parameters are then used in performing sensor diagnostics, calculating a highly-reliable fused sensor glucose value based on signals from a plurality of redundant sensing electrodes, calibrating sensors, detecting interferents within close proximity of one or more sensing electrodes, and testing surface area characteristics of electroplated electrodes. Advantageously, impedance-related parameters can be defined that are substantially glucose-independent over specific ranges of frequencies. An Application Specific Integrated Circuit (ASIC) enables implementation of the EIS-based diagnostics, fusion algorithms, and other processes based on measurement of EIS-based parameters.

Abstract: Methods for predicting at least one of the total serum bilirubin level and the hemoglobin level are proposed. The method initially uses the non-invasive measurement to detect one or more sites of the human body for acquiring the corresponding transcutaneous bilirubin and/or hemoglobin level respectively per each site. After that, the artificial intelligence is used to process the acquired results for predicting. Especially, the AI may refer to at least the detected site(s) of the human body(s) and the values of the human body related parameters. Also, the AI may be trained by process a number of measured results and comparing the predicted results with a number of invasive measurement results, such that the correlation coefficient may be approached to 1.0, at least may be about 0.9. Furthermore, neither the used non-invasive measurement nor the used AI is limited.

Abstract: An apparatus for analysis of interstitial fluid, the apparatus including an array of needles spaced apart from each other; an array of chambers separated from each other and each in fluid communication with a lumen of a corresponding one of the needles, the array of chambers comprising one or more first chambers and one or more second chambers, the one or more first chambers each containing nanoparticles functionalized to bind with a first biomarker present in the interstitial fluid, the one or more second chambers each containing nanoparticles functionalized to bind with a second biomarker present in the interstitial fluid, the first and second biomarkers being different; and an optical sensor array positioned to simultaneously detect light emitted from each of the one or more first and second chambers in response to the first or second biomarkers binding with the nanoparticles.

Abstract: Various examples are directed to systems and methods for generating an estimated analyte value. An analyte sensor system may access a first sensor signal from an in vivo analyte sensor and a first temperature signal from the ex vivo temperature sensor. The analyte sensor system may generate a first analyte sensor temperature based at least in part on the first temperature signal and generate a first estimated analyte value based at least in part on the first sensor signal and the first temperature-compensated sensitivity.

Abstract: A system includes a sensor applicator, a sensor control device arranged within the sensor applicator and including an electronics housing and a sensor extending from a bottom of the electronics housing, and a cap coupled to one of the sensor applicator and the sensor control device, wherein the cap is removable prior to deploying the sensor control device from the sensor applicator.

Abstract: In some embodiments, a method of manufacturing a metabolic sensor includes assembling a working wire for a metabolic sensor and exposing the interference layer to an oxidizing agent such as a gas. The assembly comprises forming an interference layer on a substrate, the substrate having an electrically conductive surface; forming an enzyme layer on the interference layer; and forming a glucose limiting layer on the enzyme layer. The exposing is performed prior to sterilizing the working wire.