Abstract: Disclosed is a sensor for identifying the presence of a biological material in a sample, the sensor comprising: an antenna apparatus for transmitting and receiving microwave electromagnetic (EM) signals; a signal transmitter apparatus coupled to the antenna apparatus and arranged to transmit a microwave-frequency output signal to the antenna apparatus for emission therefrom as an output electromagnetic (EM) signal for reflection at a said sample and to receive a microwave-frequency return signal from the antenna apparatus in response to a return electromagnetic (EM) signal received thereat by reflection from a said sample; a signal processor arranged to calculate a complex-valued reflection coefficient, comprising a real component and an imaginary component, according to said return signal and said output signal, and to detect the presence of said biological material in said sample according to both the real component and the imaginary component of said reflection coefficient.

Abstract: A means is provided for enabling easy identification of baggage in which one or more hazardous item is detected. An inspection system is equipped with a first conveyor, inspection device, cover, camera, controller and display. The first conveyor transports baggage to the inspection device. The inspection device captures transmitted-light images of the baggage using light that transmits through the baggage. The cover covers a transport path of the baggage to prevent a hand of a visitor from being inserted into an image shooting area where electromagnetic waves that are harmful to the human body are irradiated. The camera captures visible-light images of the baggage using visible light. The controller controls the first conveyor, inspection device, camera and display. Under control of the controller, the display simultaneously displays a transmitted-light image and a visible-light image of the baggage.

Abstract: An X-ray computed tomography apparatus images a subject while relatively rotating an X-ray source and an X-ray detector, and the subject. The X-ray computed tomography apparatus includes a theoretical image calculation unit that calculates a theoretical image obtained by irradiating a test object for calibration with X-rays using a geometrical parameter indicating a positional relationship between the X-ray source and the X-ray detector, a correction amount calculation unit that calculates a correction amount based on an amount of deviation between the theoretical image of the test object for calibration and a fluoroscopic image obtained by irradiating the test object for calibration with X-rays, and an image correction unit that corrects a fluoroscopic image of the subject using the correction amount.

Abstract: A device to host a crystallization medium, such as a solution, for crystal growth and a system for X-ray diffraction experiments to determine the atomic structure of crystals. A plurality of cells have a well, a sample holder placed in the well. The solution is hosted in the sample holder between thin-plates or one thin-plate. A cap seals an opening to the cell and each sample holder can be extracted independently from each well. A system for automated X-ray diffraction experiments for small crystals in the sample holder extracted from the wells utilizes an ultrasonic acoustic levitator to determine the crystal structure at atomic resolution. X-ray diffraction images are generated by scanning the X-ray beam over the levitated sample holder along a spiral trajectory by rotating the sample holder and moving in the direction perpendicular to the X-ray beam and the rotation axis at the same time.

Abstract: In order to provide an X-ray fluorescence analyzer that can accurately obtain a concentration of an element to be measured by generating a fluorescent X-ray only from an element to be measured or generating a very small amount of fluorescent X-ray from an element to be excluded, even in the case where, for example, atomic numbers of a plurality of elements contained in a liquid sample are close to each other such as in phosphorus (P) and silicon (Si), an X-ray fluorescence analyzer is configured to analyze a liquid sample containing a first element to be measured and a second element having the atomic number larger than the atomic number of the first element, the X-ray fluorescence analyzer including: an X-ray source that emits a first X-ray; a secondary target that generates the second X-ray by being excited by the first X-ray; a detector and a concentration calculator.

Abstract: Methods and devices for mass spectrometry are described, specifically the use of nanoparticulate implantation as a matrix for secondary ion and more generally secondary particles. A photon beam source or a nanoparticulate beam source can be used a desorption source or a primary ion/primary particle source.

Abstract: Described is a differential scanning calorimeter (DSC) instrument capable of performing analyses of multiple samples at the same time. Some embodiments of DSC instruments described herein include a thermal substrate that provides a substantially uniform temperature across a surface of the substrate. A plurality of DSC units is in thermal communication with the substrate, for example, by mounting the units directly to the surface of the substrate. Each DSC unit includes a second thermal substrate for further thermal isolation, and a reference platform and sample platform to receive a reference cell and a sample cell, respectively. A thermoelectric device is disposed between each platform and the second thermal substrate. Optionally, the reference and sample cells may be disposable chips that can be discarded after measurement are performed, thereby reducing or eliminating the need to clean instrument components to prevent cross-contamination for subsequent instrument operation.

Abstract: A fluid sensor for sensing a concentration or composition of a fluid, the sensor comprising: a semiconductor substrate comprising a first etched portion and a second etched portion; a dielectric region located on the semiconductor substrate, wherein the dielectric region comprises a first dielectric membrane located over the first etched portion of the semiconductor substrate, and a second dielectric membrane located over the second etched portion of the semiconductor substrate; two temperature sensing elements on or within the first dielectric membrane and two temperature sensing elements on or within the second dielectric membrane; an output circuit configured to measure a differential signal between the two temperature sensing elements of the first dielectric membrane and the two temperature sensing elements of the second dielectric membrane; wherein the first dielectric membrane is exposed to the fluid and the second dielectric membrane is isolated from the fluid.

Abstract: The present disclosure provides a three-dimensional hydrogel-graphene-based biosensor and a preparation method thereof, belonging to the technical field of biosensors. The present disclosure provides a three-dimensional hydrogel-graphene-based biosensor, including a substrate, an electrode layer, a graphene film, and a three-dimensional hydrogel material layer that are stacked in sequence; where the three-dimensional hydrogel material layer is formed of a hydrogel material having a three-dimensional network structure; the hydrogel material is obtained by polymerization of raw materials including an acrylamide monomer and a modified probe molecule; and the modified probe molecule is a probe molecule modified with an acrylamide group. The three-dimensional hydrogel-graphene-based biosensor has a desirable stability and a high sensitivity.

Abstract: A hydrogen sensor assembly includes a mounting portion; a sensor portion disposed adjacent to the mounting portion; and at least one pedestal connecting the sensor portion to the mounting portion, the sensor portion includes a metal oxide semiconductor having a hydrogen sensing surface and the hydrogen sensing surface includes a noble metal dopant.

Abstract: [Object] To provide a compact and reusable alkene-detection gas sensor that detects an alkene and a system using the same. [Solving Means] An alkene-detection gas sensor that detects an alkene in a sample gas according to the present invention includes: a first reaction unit that contains a palladium catalyst and oxidizes an alkene in a sample gas to convert the alkene into an aldehyde and/or a ketone; a second reaction unit that contains hydroxylamine salts and reacts with the aldehyde and/or ketone converted in the first reaction unit to generate an acid; and a response unit that includes an electrode supporting a semiconductor material of which an electrical resistance value changes by the generated acid, in which the palladium catalyst, the hydroxylamine salts, and the semiconductor material are separated from each other.

Abstract: A humidity measuring device is equipped with a temperature and humidity measurement unit including a temperature sensing element that measures temperature and a humidity sensing element that measures humidity, a casing having an accommodating section in which the temperature and humidity measurement unit is accommodated, and a supply tube that supplies a gas at a measurement location into the accommodating section, and a display unit having a display device, and which is fixed to the casing. The display unit further includes a display control unit that controls the display device to thereby cause the display device to display at least one of the humidity of the gas measured by the humidity sensing element, or a dew point temperature of the gas calculated based on the temperature of the gas measured by the temperature sensing element, and the humidity of the gas measured by the humidity sensing element.

Abstract: A sensor for measuring ocean water salinity is described. The sensor may include a measurement clock circuit, a control clock circuit, and a comparator circuit. The measurement clock circuit, having an output that varies with salinity of a fluid, may have a first circuit architecture that includes a capacitive gap assembly that permits a fluid to flow into a gap between two electrodes of the capacitive gap assembly. The control clock circuit, having an output that does not vary with salinity of the fluid, may have a second circuit architecture comprising a capacitor. The comparator circuit may be configured to compare the controlled clock output to the measured clock output over a duration of time to determine a salinity measurement of the fluid.

Abstract: A probe for measuring a sample solution includes an outer body configured to receive an operational amount of a reference solution, and a sensor assembly including an inner body at least a portion of which is located inside the outer body. A shield is positioned between the outer surface of the inner body and the inner surface of the outer body. The shield is configured to be in contact with the reference solution and extends above the top surface of the reference solution when the probe is filled with an operational amount of the reference solution.

Abstract: A water pH detection sensor and a use of a ruthenium-iridium electrode as a PH sensing material. The water pH detection sensor includes a ruthenium-iridium electrode and a reference electrode, and the pH value of a solution to be detected is obtained by means of a voltage between the ruthenium-iridium electrode and the reference electrode. The ruthenium-iridium electrode is used as the pH sensing material, the electrode potential of the material in a solution has a good linear correspondingly relationship with a hydrogen ion concentration, and the material has the features of a wide pH value response range, a high response speed, a stable response performance and repeated measurement and use, and is suitable for different practical application scenarios.

Abstract: Embodiments of the present disclosure pertain to methods of capturing one or more ions from an environment by associating the environment with a composition that includes a metal-organic framework. The association results in the capture of the one or more ions by the metal-organic framework. The metal-organic frameworks may include a plurality of metals and a plurality of triphenylene-based ligands that interconnect the plurality of the metals. The methods of the present disclosure may also include a step of detecting one or more captured ions. Additional embodiments of the present disclosure pertain to the compositions for capturing one or more ions from an environment.

Abstract: Potentiometric sensors based on potentiometric mechanosensation and/or thermosensation mechanisms operate by regulating the potential difference between electrodes at two different electrode/electrolyte interfaces. A potentiometric sensor may include at least a first electrode, a second electrode, and a microstructured ionic hydrogel composite electrolyte in contact with the first electrode and the second electrode. Methods of making a potentiometric sensor device may include forming a first electrode on a substrate, forming a second electrode on the substrate, and applying a microstructured ionic hydrogel composite electrolyte structure in contact with both the first and second electrodes.

Abstract: An analysis device measures ion concentration in a sample to detect an abnormality using an ion selective electrode. The analysis device includes an ion selective electrode that obtains a potential based on the ion concentration, a reference electrode that obtains a potential based on a reference liquid, a measurement unit that measures an electromotive force between the ion selective electrode and the reference electrode, an analyzer that analyzes a potential change of the electromotive force in a certain time region, and a storage that stores abnormality analysis data indicating a relation between the potential change and an abnormality of the analysis device. The analyzer acquires a parameter for the potential change of the electromotive force measured by the measurement unit, and analyzes the abnormality of the analysis device based on the parameter and the abnormality analysis data stored in the storage.

Abstract: The present invention relates to a method for product identification comprising subjecting a sample to cyclic voltammetry, wherein the sample is subjected to a plurality of voltammetric cycles to obtain a data set for each cycle and wherein the data sets comprise data points; and comparing the data set for each cycle with a data set for a corresponding cycle of at least one known product to determine whether the sample is the known product. The present invention further relates to a method for determining a profile for a known product, which may be used in determining the identity of a sample.

Abstract: The present disclosure provides a gas analysis device and a method for detecting sample gas. The gas analysis device includes: an ion mobility spectrometer including an ion mobility tube, an ion gate, a plurality of electrodes, a suppression grid, and a Faraday plate sequentially disposed in the ion mobility tube, wherein the Faraday plate is configured to receive sample ions discharged from the suppression grid, and the Faraday plate is provided with a through hole; a mass spectrometer; a gate valve disposed between the Faraday plate and an ion inlet of the mass spectrometer; and a controller configured to control an opening or closing of the gate valve to allow the sample ions discharged from the suppression grid to flow into the mass spectrometer through the through hole of the Faraday plate when the gate valve is opened.

Abstract: The present invention discloses a sensor system for estimating respective amounts of different molecules in a biological liquid, and the sensor system includes: an electronic circuit module and a Shear Horizontal Surface Acoustic Wave (SH-SAW) sensor, wherein the electronic circuit module has more than two different impedance matching circuits for exciting and detecting a plurality of Surface Acoustic Waves (SAWs) with different frequencies, and the SH-SAW sensor has at least one transducer and a surface on which the plurality of SAWs propagate, and wherein the surface is covered with a probe to be bound with more than two different molecules.

Abstract: A system comprising a computer readable storage device readable by the system, tangibly embodying a program having a set of instructions executable by the system to perform the following steps for indication confirmation for detecting a sub-surface defect, the set of instructions comprising: an instruction to initialize a transducer starting location and a transducer orientation responsive to a prior determination of a potential flaw location; an instruction to optimize an observation point of the transducer responsive to the transducer starting location and the transducer orientation responsive to a flaw response model; an instruction to move the transducer to the observation point location and orientation; an instruction to collect the scan data at the observation point location and orientation; and an instruction to analyze the scan data to extract a measure of the flaw response model; and an instruction to update the flaw response model.

Abstract: A resonance detection system includes a vibration simulation mechanism and a vibration audio analysis device. The vibration simulation mechanism includes a mechanism body that accommodates a peripheral interface device. The vibration simulation mechanism generates a vibration wave to the peripheral interface device. The peripheral interface device generates a vibration audio signal in response to the vibration wave. The vibration audio analysis device is electrically connected with the vibration simulation mechanism. After the vibration audio signal is inputted into the vibration audio analysis device, the vibration audio analysis device judges whether there is an abnormal resonance phenomenon in the vibration audio signal. The vibration simulation mechanism further includes a patch-type audio collector, which is electrically connected with the vibration audio analysis device. The patch-type audio collector is attached on the mechanism body containing the peripheral interface device.

Abstract: A system for estimating both thickness and wear state of refractory material (1) of a metallurgical furnace (12), including at least on processor including a database of simulated frequency domain data named simulated spectra representing simulated shock waves reflected in simulated refractory materials of known state and thickness, each simulated spectrum being correlated with both known state and thickness data of the considered simulated refractory material, wherein the at least one processor is configured to record a reflected shock wave as a time domain signal, and to convert it into frequency domain data named experimental spectrum, and are further configured to compare the experimental spectrum with at least a plurality of simulated spectra from the database, to determine the best fitting simulated spectrum with the experimental spectrum and to estimate thickness and state of the refractory material (1) of the furnace (12) using known state and thickness data correlated with the best fitting simulated

Abstract: A system comprising a computer readable storage device readable by the system, tangibly embodying a program having a set of instructions executable by the system to perform the following steps for detecting a sub-surface defect, the set of instructions comprising an instruction to receive scan data for a part from a transducer; an instruction to collect the scan data; an instruction to determine an indication in the scan data that indicates a distractor, wherein the indication is based on a learning phase module and an inference phase module that the processor uses to self-assess the indication; and an instruction to create a defect indication report.

Abstract: A fluidic device and a method of preventing isolation material from bleed-out therein is described herein. The fluidic device includes a bulk acoustic wave resonator structure defining at least one surface area region on which a functionalization material is disposed and the resonator structure includes a repelling area. The fluidic device also includes isolation material disposed on the resonator structure and away from the at least one surface area region. The repelling area is configured to prevent the isolation material from extending into the at least one surface area region. Further, an electronic board may be operably attached to the resonator structure and the isolation material may be disposed in a gap therebetween to electrically isolate electrical contacts and form a fluidic channel.

Abstract: A system for detecting a sub-surface defect comprising a transducer fluidly coupled to a part located in a tank containing a liquid configured to transmit ultrasonic energy, the transducer configured to scan the part to create scan data of the scanned part; a pulser/receiver coupled to the transducer configured to receive and transmit the scan data; a processor coupled to the pulser/receiver, the processor configured to communicate with the pulser/receiver and collect the scan data; and the processor configured to detect the sub-surface defect and the processor configured to have a sub-surface defect confidence assessment and a prioritization for further human evaluation.

Abstract: A sampling needle (2) having a suction port at a tip, a movement mechanism (4) that moves the needle (2) at least in a vertical direction while holding the needle (2) in a state where the suction port faces vertically downward, a suction mechanism (6) for sucking liquid through the needle (2), a controller (10) configured to control operation of the movement mechanism (4) and the suction mechanism (6) are included.

Abstract: Disclosed is a method for determining an operating flow rate for a chromatographic column (4) in an HPLC system (1). The method comprises: measuring/calculating a pressure of the system (1) without the chromatographic column (4) for one or more flow rates; fitting a function to the flow rate(s) and corresponding pressure(s), calculating from the function and a predetermined recommended flow rate for the chromatographic column (4) a system pressure drop at the predetermined recommended flow rate. An operating flow rate is determined by summing the system pressure drop and a maximal column pressure limit, and determining a contribution of the system pressure drop to the summed pressure. If this contribution exceeds 1% an operating flow rate for the column is determined to a flow rate that corresponds to a pressure at a pressure monitor arranged before the column that is lower than the predetermined maximum column pressure limit.

Abstract: This disclosure describes multi-fluid kits for three-dimensional printing, three-dimensional printing kits, and methods of sensing metal ions using three-dimensional printed ion sensors. In one example, a multi-fluid kit for three-dimensional printing can include a fusing agent and an ion-sensing agent. The fusing agent can include water and an electromagnetic radiation absorber. The electromagnetic radiation absorber can absorb radiation energy and convert the radiation energy to heat. The ion-sensing agent can include water and a redox-active inorganic salt.

Abstract: The invention relates to a polymeric indicator fixed in a polymeric gel carrier, wherein the polymeric gel carrier comprises a hydrophilic polymer, wherein the polymeric indicator and the hydrophilic polymer are present together in the form of a combined cross-linked hydrogel network fixed by chemical bonds. The invention further relates to a method for preparing a polymeric indicator fixed in a polymeric gel carrier and to a sensor for measuring pH, which comprises the polymeric indicator fixed in a polymeric gel carrier.

Abstract: Methods, apparatuses and systems for calibrating gas detectors are disclosed. An example calibration apparatus may have a gas supply element configured to provide a background gaseous substance within at least a portion of the calibration apparatus, a nebulizing element configured to generate the testing gaseous substance by transforming a testing solution in conjunction with the background gaseous substance, a pressure control element configured to regulate airflow in order to maintain a constant air pressure within the at least a portion of the calibration apparatus, and a controller component in electronic communication with the gas supply element, the nebulizing element and the pressure control element.

Abstract: A quality control system analyzes the quality of a battery cell, with the battery cell defining a gas pouch configured to be filled with a gas. The quality control system includes a computational system including a processor and a memory, a manifold defining a passageway extending between an inlet port for receiving the gas and an outlet port, and at least one sensor in electronic communication with the computational system. The sensor is arranged to measure a physical property of the gas and transmit a signal to the computational system corresponding to the physical property of the gas. The computational system analyzes the physical property of the gas, accesses a threshold value corresponding to the physical property, compares the physical property to the threshold value, and assess a quality score for the battery cell. A corresponding method analyzes the quality of the battery cell with the quality control system.

Abstract: An in vitro release testing (IVRT) device for orally inhaled drug products, for use in an IVRT apparatus, the device having an air-permeable filter loaded with particulate material representing a dose of an orally inhaled drug product. The device has an upper filter support element and a lower filter support element, the loaded filter being circumferentially retained between the upper and lower support elements, a filter cover to cover the upper surface of the loaded filter, and a filter cover retainer provided to assemble and seal the IVRT device.

Abstract: A method and system for measuring an amount of a gas dissolved in a liquid is described, in which the liquid is transferred to an equilibrator and in which the amount of the various gases is measured in the gas phase of the equilibrator and that a calculation of the amount of gas which is dissolved in the liquid is carried out.

Abstract: Described herein are systems, methods, and devices for detecting harmful algae blooms. An example system includes autonomous watercraft; and a computing device operably connected to the autonomous watercraft over a network, the computing device including a processor and a memory having computer-executable instructions stored thereon that cause the processor to: surveil a body of water for an algae growth; receive a local condition at the body of water; predict a spread of the algae growth in the body of water based on the local condition; determine a deployment strategy for the autonomous watercraft based on the spread of the algae growth; and transmit one or more control signals to the plurality of autonomous watercraft based on the deployment strategy, where the autonomous watercraft are configured to collect and analyze a plurality of water samples to determine whether the algae growth is a harmful algae bloom.

Abstract: The present disclosure relates to methods of verifying enhanced rock weathering using immobile trace elements found within a mineral amendment. Further disclosed are mineral amendments that enable enhanced rock weathering.

Abstract: The present invention provides a method for estimating hydrocarbon saturation of a hydrocarbon-bearing rock from a resistivity log and a rock image. The image is segmented to represent either a pore space or solid material in the rock. An image porosity is estimated from the segmented image, and a corrected porosity is determined to account for the sub-resolution porosity missing in the image of the rock. A corrected cementation exponent of the rock is determined from the image porosity and the corrected porosity and is used to estimate the hydrocarbon saturation. A backpropagation-enabled trained model can be used to segment the image. A backpropagation-enabled method can be used to estimate the hydrocarbon saturation using an image selected from a series of 2D projection images, 3D reconstructed images and combinations thereof.

Abstract: A system for performing a downhole optical analysis includes a housing positioned in a wellbore extending into a formation. The system also includes a carrier arranged within the housing, the carrier being coupled to a power supply. The system further includes a catalyst coating at least a portion of the carrier. The system also includes a regulated inlet providing a fluid pathway into a reaction chamber that includes at least a portion of the catalyst. The system further includes a detector arranged relative to the reaction chamber to detect a signal emitted via an interaction between the catalyst and a fluid sample introduced into the housing.

Abstract: An improved system and apparatus for testing thermal fluids in which the condition of a heat transfer fluid is measured. The system includes a sample vessel with a sample inlet for receiving a sample of heat transfer fluid from the heat transfer system and a sample outlet for returning the sample of heat transfer fluid to the heat transfer system, a heat transfer fluid condition monitor in fluid contact with the sample vessel measures one or more physical parameters of the heat transfer fluid and a control system which controls operation of the condition monitor and the sample vessel and which analyses the measured physical parameters of the heat transfer fluid. The system provides for predictive maintenance which is significantly more cost effective than preventative maintenance. It also ensures, as far as possible, that preventative maintenance can also be carried out while the system is running in normal production mode.

Abstract: Disclosed herein is a system for performing urinalysis of transurethral patients. The system includes a tubing set to receive urine from a urethral catheter. A detector assembly is operatively coupled between the tubing set and a urinalysis module coupled. The system can perform urinalysis of a urine sample disposed within the tubing set and render urinalysis information on a display of the module. Also disclosed is a method of performing urinalysis that can include operations of: (i) placing a urine sample within a cuvette of a urinalysis system, the cuvette including a lumen extending between an inlet and an outlet; (ii) projecting coherent light into the sample; (iii) collecting output light exiting the sample; (iv)extracting urinalysis data from the collected light; and (v) rendering urinalysis results on a display of the system.

Abstract: A microfluidic system for measuring cell adhesion includes a gas impermeable housing including at least one microchannel defining at least one cell adhesion region, the at least one cell adhesion region being provided with at least one capturing agent that adheres a cell of interest to a surface of the at least one microchannel when a fluid sample containing cells is passed through the at least one microchannel, and an imaging system for measuring the adherence of cells of interest adhered by the at least one capturing agent to the surface of the at least one microchannel when the fluid sample is passed therethrough.

Abstract: Embodiments of the present disclosure include methods and systems for detecting the presence of endotoxins in filters. For example, embodiments of the present disclosure are directed to methods and systems for improving in-process controls by detecting undesirable quantities of endotoxins in filters containing naturally-sourced materials prior to using those filters in the production of formulated drug substances.

Abstract: The present disclosure relates to compositions and methods for the preparation and use of free fatty acids as crystals and in solution, optionally in array format, for assay of lipotoxicity and related effects (in certain cases, indicators of diseases or disorders, such as type II diabetes) in contacted cells. Identification and therapeutic targeting of high-value gene targets discovered via joint assessment of lipotoxicity/transcriptome data and genetic association study data are also provided.

Abstract: The invention relates to compositions and methods for making and use of a real-time cellular sensor. Components of a multipart enzyme are sequestered in different cellular compartments and only come together after receptor activation; a pool of substrate is made available in the cell to ensure real-time enzymatic output.

Abstract: The present disclosure provides an in vitro cell based potency assay to determine the relative potency of a composition, including a pharmaceutical composition, comprising an mRNA encapsulated in a lipid nanoparticle (LNP) as compared to a reference sample. Also provided is a process for releasing or accepting a batch of a pharmaceutical composition comprising an mRNA encapsulated in an LNP using the in vitro cell based potency assay. The methods and processes described comprise (i) transfecting a population of cells with a test sample of the composition, (ii) transfecting a different population of cells with a reference sample of the pharmaceutical composition, wherein the cells in step (ii) are the same cell type as the cells in step (i); (iii) detecting the amount of expression of a polypeptide encoded by the mRNA in the transfected cells; and comparing the amount of expression, thereby determining the relative in vitro potency of the composition.

Abstract: Disclosed is a spheroid liver organoid comprising hepatic lineage cells such as human hepatocytes, hepatic stellate cells, and liver sinusoidal endothelial cells. Also provided are methods of using spheroid liver organoids for applications related to drug screening and toxicity screening. In particular, spheroid liver organoids are useful for high-throughput screens to identify compounds having efficacy for treating liver disease.

Abstract: Described in certain example embodiments herein are systems, methods, and uses thereof for high-throughput in vitro evaluating multiple test compounds in parallel for biological or pharmacological functions. In certain embodiments, the system allows the selection of a subset of test compounds from a group of test compounds to form an optimized pool, and methods are provided to use such optimized pool of test compounds to identify and validate therapeutic agents for treating diseases and driving guided differentiation of stem cells into desired types of cells. The systems described herein can provide, for example, a cost-effective and high-quality high-throughput approach for drug screening.

Abstract: The present invention relates to a method for measuring the immune-mediated effect of one or more immunotherapeutic agents on patient derived tumour cultures, using 3-dimensional visualisation of the tumour cell cultures. It also relates to the tumour cell cultures, and to a kit of parts comprising cell cultures and apparatus.

Abstract: Disclosed is a device including a substrate having a plurality of detection areas to receive at least a portion of a sample having an analyte or suspected of having an analyte and at least one reference marker adjacent to at least one of the detection areas, wherein each of the detection areas detects a specific analyte and the at least one reference marker defines a scale mark, a shape mark, a color mark, or a combination thereof. Also disclosed is an imaging system and method for using the device and imaging system.