Patents Issued in March 7, 2023
  • Patent number: 11596573
    Abstract: A system and method for thought-based control of sexual stimulation devices using electroencephalography. The system and method involve a training phase and an operation phase. In an embodiment, the training phase comprises placing electrodes on the head of a person, measuring electrical signals produced by the person's brain via the electrodes while the user engages in one or more thought-based training tasks, associating patterns of electrical activity in the person's brain while performing the tasks with controls of the sexual stimulation device. In an embodiment, the operation phase comprises generating control signals for the sexual stimulation device based on the associations when the patterns of electrical activity are detected by the electrodes. In some embodiments, machine learning algorithms are used to detect the patterns of electrical activity and make the associations. In some embodiments, data from other biometric sensors is included in the associations.
    Type: Grant
    Filed: June 13, 2022
    Date of Patent: March 7, 2023
    Inventor: Brian Sloan
  • Patent number: 11596574
    Abstract: A massage device for massaging by means of pressure waves includes a housing having a handle segment and a massage segment and at least one chamber comprising an opening leading outward in the massage segment. The chamber includes an end wall segment, a first circumferential wall segment, and a second circumferential wall segment, the first circumferential wall segment being disposed between the end wall segment and the second circumferential wall segment, and the second circumferential wall segment defining the opening with the end wall segment being at least partially displaceable. The massage device further includes a drive device for inducing a predetermined vibration in the end wall segment, with the first circumferential wall segment being substantially rigid and the second circumferential wall segment being substantially flexible.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: March 7, 2023
    Assignee: FUN FACTORY GMBH
    Inventors: Michael Pahl, Dirk Bauer
  • Patent number: 11596575
    Abstract: A CPR apparatus includes a chest compression unit and a means for mounting the chest compression unit on a patient. The chest compression unit includes a plunger disposed in a housing. At its one end extending from the housing the plunger has a compression member. The plunger is driven in a reciprocating manner by a reversible electromotor via a mechanism for translating rotational motion to linear motion or by a linear induction electromotor. The chest compression unit includes an electromotor control unit including a microprocessor, a first monitor for monitoring the position of the plunger in respect of the housing and a second monitor for monitoring the position of the plunger in respect of the mechanism for translating rotational motion to linear motion or the rotor of the linear induction electromotor. The monitored positions are communicated to the electromotor control unit. Also disclosed is a corresponding CPR method.
    Type: Grant
    Filed: June 8, 2019
    Date of Patent: March 7, 2023
    Assignee: PHYSIO-CONTROL, INC.
    Inventors: Anders Nilsson, Anders Jeppson
  • Patent number: 11596576
    Abstract: An acupuncture robot and an intelligent acupuncture system and method are provided. The acupuncture robot includes an acupuncture treatment host, a treatment electrode and a palm fixing frame, wherein the palm fixing frame is used for fixing a palm, and the treatment electrode is used for carrying out acupuncture massage treatment on holographic acupuncture points of a second metacarpal bone of the palm of a patient; and the acupuncture treatment host is in communication connection with a server to acquire an operation instruction, instructs, according to the operation instruction, the patient to use the acupuncture robot, and controls, according to the operation instruction, the treatment electrode such that same carries out acupuncture massage treatment on the holographic acupuncture points of the second metacarpal bone of the patient. The intelligent acupuncture system includes the acupuncture robot and the server.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: March 7, 2023
    Inventor: Xibi Dong
  • Patent number: 11596577
    Abstract: A package has a plurality of seamless compartments coupled together. A different one of the plurality compartments each includes a different respective one of a plurality of respective void spaces and a different respective one of a plurality of respective void space delimiting surfaces. A different one of a plurality of fill entries each forms a fluent entry into a different respective compartment's void space. At least one fill entry of said plurality is in an elastomeric portion of said package, and the at least one fill entry has a largest cross sectional area which is equal to or less than 25% of a largest cross sectional area of the compartment having the respective void space for which the fill entry forms the fluent entry. Each void space delimiting surface follows an outline of a separate 3D pill shape.
    Type: Grant
    Filed: September 15, 2019
    Date of Patent: March 7, 2023
    Inventor: Craig Robertson
  • Patent number: 11596578
    Abstract: A pill grinder and a method for using thereof are provided. The pill grinder includes: a base plate; a guiding assembly; a handle component including a pair of handle connecting rods, wherein, a first connecting rod is connected to a first end of each handle connecting rod, a roller shaft is connected between the handle connecting rods, axial directions of the roller shaft and the first connecting rod are both parallel to a first direction, the first connecting rod is kept pressed towards the base plate by an elastic returning component; and a grinding component, sleeved outside the roller shaft. When the handle component rotates around the first connecting rod, guided by the guiding assembly, the grinding component has a grinding stroke along a second direction perpendicular to the first direction. Therefore, pills can be better grinded with easier operation and less time, and safety in use is largely enhanced.
    Type: Grant
    Filed: February 7, 2021
    Date of Patent: March 7, 2023
    Inventor: Song Yang
  • Patent number: 11596579
    Abstract: An apparatus and method for holding a container comprising of a carriage and timing mechanism. The apparatus is comprised of a lever with at least two positions relative to the carriage, a timer, and a timer reset mechanism such that when the lever is in the first position, the timer will start counting time. When the lever is moved to the second position, the timer reset mechanism will modify the timer such as by resetting the amount of time that has been counted. The user thus knows how much time has passed since the user last changed the position of the lever.
    Type: Grant
    Filed: January 25, 2021
    Date of Patent: March 7, 2023
    Inventor: Amir Akbar Sadigh Behzadi
  • Patent number: 11596580
    Abstract: A nursing bottle having an air returning function comprises a bottle body, a fixing cover, a nipple, a ventilation component, an air conduit, an elastic one-way valve set at a second opening of the air conduit and is located at the interior of the air conduit, a mounting part located on the second opening of the air conduit to secure the elastic one-way valve. The ventilation component, the air conduit, the elastic one-way valve and the mounting part form a gas returning device and are located on the interior of the bottle. The bottle reduces the contacting area between the air and the milk, lowering the amount of vitamin loss. The phenomenon of vomiting milk, choking and flatulence will be omitted since no air bubble is generated.
    Type: Grant
    Filed: September 3, 2019
    Date of Patent: March 7, 2023
    Inventor: Qingyang Sun
  • Patent number: 11596581
    Abstract: A pacifier assembly device comprising two pacifier components. The pacifier components are assembled together using a connection component. When assembled together, opposing nipple-like protrusions of each pacifier component assists an infant with successfully positioning one of the protrusions into its mouth. When disassembled, the pacifier components may each be used individually or thoroughly cleaned and sanitized.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: March 7, 2023
    Inventor: Nakia Dawn Hall
  • Patent number: 11596582
    Abstract: The present invention relates to particles comprising a core, in particular a magnetic core, and a first coating of a first shell material, wherein a second coating of a second shell material is applied to the surface of the first coating facing away from the core, the second shell material is different from the first shell material and has a higher refractive index than the first shell material.
    Type: Grant
    Filed: August 16, 2019
    Date of Patent: March 7, 2023
    Assignee: Ivoclar Vivadent AG
    Inventors: Kai Rist, Annette Schmidt, Ahmad Shaaban
  • Patent number: 11596583
    Abstract: Provided are: a core-corona polymer particle excellent in emulsion stability and feeling of use, and a raw material for a cosmetic and an oil-in-water emulsion cosmetic comprising the particle. Certain embodiments of the present invention provides a core-corona polymer particle obtained by radical-polymerizing a polyethylene oxide macromonomer represented by formula (1) and one or two or more of hydrophobic monomers represented by formulas (2) and (3) under conditions (A) to (D).
    Type: Grant
    Filed: March 22, 2019
    Date of Patent: March 7, 2023
    Assignee: Shiseido Company, Ltd.
    Inventors: Yuki Sugiyama, Ryushi Fukuhara
  • Patent number: 11596584
    Abstract: Disclosed are stable, non-irritating, skin treatment active agents containing formulations and delivery systems for topical application to the skin. The disclosed topical formulations and delivery systems provide controlled, gentle release of the active agents into the skin for the treatment of amenable skin conditions as well as for improvement of aesthetic skin properties. Also provided are methods for the formulation, manufacture and use of the disclosed formulations and delivery systems.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: March 7, 2023
    Assignee: Topix Pharmaceuticals, Inc.
    Inventor: Steven M. Hernandez
  • Patent number: 11596585
    Abstract: A composition for reducing microbial activity in an environment susceptible to microbial activity, comprising: metallic nanoparticles; and an oxygenation agent.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 7, 2023
    Inventor: Ingrid Rodriguez
  • Patent number: 11596586
    Abstract: Topical personal care compositions containing amino acids and 4-substituted resorcinols for potentiating glutathione synthesis within skin cells. The compositions can be used to improve skin appearance of chronological aging or photoaging, resulting from exposure to UV light/sunlight, or environmental pollutants. The compositions are also useful for attaining even skin color and reducing pigmentation, age spots and discoloration.
    Type: Grant
    Filed: January 31, 2022
    Date of Patent: March 7, 2023
    Assignee: Conopco, Inc.
    Inventors: Marian Pereira Guelakis, Jianming Lee, Jose Guillermo Rosa, Stephen Alan Madison, Tingyan Ml, Anita Damodaran, Annu Kumari, Nan Huang, Bijan Harichian
  • Patent number: 11596587
    Abstract: Consumable abrasive-containing oral hygiene tablets are described. The tablets include glycine as an abrasive. The glycine average (Mv) particle size may be greater than 45 ?m. The tablets may be used with an oral irrigator and, when placed in the irrigator's fluid flow path, may disintegrate, release the abrasive, and improve the cleaning efficacy of the irrigator.
    Type: Grant
    Filed: March 11, 2021
    Date of Patent: March 7, 2023
    Assignee: WATER PIK, INC.
    Inventor: Clifford Snyder
  • Patent number: 11596588
    Abstract: The present disclosure relates to color-altering compositions. The compositions comprise a hair color-altering agent and at least one carboxylic acid. Certain compositions further comprise at least one amino acid or amino sulfonic acid, and/or a salt thereof selected from the group consisting of taurine, aspartic acid, cysteine, lysine, methionine, tyrosine, phenylalanine, carnitine, a salt thereof, and a mixture thereof. Also provided are kits and methods of using said color-altering compositions.
    Type: Grant
    Filed: December 28, 2018
    Date of Patent: March 7, 2023
    Assignee: L'OREAL
    Inventors: Sarah Barrie Machover, Karl Wunsch, Aurélie Camblong, Agathe Lahaye, Fabien Boulineau
  • Patent number: 11596589
    Abstract: Peptides are provided herein, wherein the peptide bearing one or more amino acid sequence differences relative to SEQ ID NO: 1, with the amino acid sequence differences comprising at least one cysteine replacement.
    Type: Grant
    Filed: December 18, 2021
    Date of Patent: March 7, 2023
    Assignee: Purvala Bioscience, Inc.
    Inventor: Justin Paloni
  • Patent number: 11596590
    Abstract: Methods and kids for removing calculus from a tooth. The method can include applying a component A comprising a hydrogen peroxide or a precursor thereto and a component B the comprising a catalase to the tooth, thereby generating oxygen; and removing at least a part of the calculus from the tooth.
    Type: Grant
    Filed: June 21, 2017
    Date of Patent: March 7, 2023
    Assignee: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: Tao Gong, Petra L. Kohler Riedi, Evan Koon Lun Yuuji Hajime, Steven P. Swanson
  • Patent number: 11596591
    Abstract: A method for manufacturing a fucoidan cosmetic composition includes: washing mozuku to eliminate residual salt and impurities; adding citric acid to the washed mozuku and pulverizing the mozuku; adding water to the pulverized mozuku and performing reflux extraction to obtain a high molecular weight fucoidan; adding a neutralizing agent to the high molecular weight fucoidan for neutralization; adding diatomite to the neutralized high molecular weight fucoidan and causing a reaction for 30 minutes for deodorization; filtering the deodorized high molecular weight fucoidan to eliminate insoluble substances; adding a lactic acid bacterium to the high molecular weight fucoidan removed of the insoluble substances and causing fermentation to obtain a low molecular weight fucoidan; concentrating the purified low molecular weight fucoidan with a reduced pressure evaporator; and powdering the concentrated low molecular weight fucoidan through freeze drying.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: March 7, 2023
    Assignee: MS Global Bio Co., Ltd
    Inventors: Nam Ock Chung, In Deok Kim, Hyeon Seong Jeong
  • Patent number: 11596592
    Abstract: The present disclosure relates to a soluble microneedle and a filler composition with an excellent anti-wrinkle effect. Using the microneedle according to the present disclosure, crosslinked hyaluronic acid (hyaluronic acid filler material) can be intradermally or subcutaneously administered by a simple method, and a swelling property of the crosslinked hyaluronic acid is improved after administration, thereby exhibiting the excellent anti-wrinkle effect.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: March 7, 2023
    Assignee: LG HOUSEHOLD & HEALTH CARE LTD.
    Inventors: Jun-Seok Yeom, Woo-Sun Shim, Young-Min Hwang, Seung-Min Yoo, Seol-Hoon Lee, Nae-Gyu Kang
  • Patent number: 11596593
    Abstract: Oral care compositions comprising: (a) a peroxide complex comprising a peroxide component and an N-vinyl heterocyclic polymer (e.g., poly-N-vinyl polylactam, or poly-N-vinyl-polyimide); (b) a whitening agent (e.g., hydrogen peroxide); and (c) an orally acceptable carrier. In one embodiment, the carrier comprises a film forming material. Methods are also provided for making an oral care composition comprising: (a) mixing a whitening agent, silicone adhesive and carrier fluid to form a homogenous mixture; (b) adding a peroxide complex to said homogenous mixture, wherein said complex comprises hydrogen peroxide and an N-vinyl heterocyclic polymer; and (c) mixing under vacuum.
    Type: Grant
    Filed: January 22, 2021
    Date of Patent: March 7, 2023
    Assignee: Colgate-Palmolive Company
    Inventors: Lynette Zaidel, Guisheng Pan, Suman Chopra, Prakasarao Mandadi, Michael Prencipe
  • Patent number: 11596595
    Abstract: Intravesical drug delivery devices that include a device body, a number of solid drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The drug tablets is positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: March 7, 2023
    Assignee: TARIS Biomedical LLC
    Inventors: Heejin Lee, Cheryl Larrivee-Elkins
  • Patent number: 11596596
    Abstract: Methods of treating neuropathic pain in spinal cord injured individuals by administering levetiracetam or brivaracetam are described.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: March 7, 2023
    Assignee: CNS BIOSCIENCES, INC.
    Inventor: Scott P. Falci
  • Patent number: 11596597
    Abstract: A pharmaceutical long acting depot composition is provided as an aid to smoking cessation treatment. The formulation comprises a therapeutically effective amount of varenicline or its pharmaceutically acceptable derivative and pharmaceutically acceptable excipients. The process of preparation of the formulation is also provided.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: March 7, 2023
    Assignee: Cipla Limited
    Inventors: Geena Malhotra, Sarabjit Singh
  • Patent number: 11596598
    Abstract: An anti-tumor composition for nasal administration has chlorogenic acid as an active ingredient, with the addition of pharmaceutically acceptable excipients or auxiliary ingredients. The chlorogenic acid preparation can improve the bioavailability of chlorogenic acid for nasal administration, penetrate the blood-brain barrier, have a significant inhibitory effect on brain tumors and nasopharyngeal carcinoma, and possess a clinical application value.
    Type: Grant
    Filed: October 1, 2020
    Date of Patent: March 7, 2023
    Assignee: SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Jie Zhang, Wang Huang, Fei Zhang, Ya Zhang
  • Patent number: 11596599
    Abstract: Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
    Type: Grant
    Filed: February 8, 2021
    Date of Patent: March 7, 2023
    Assignee: The Johns Hopkins University
    Inventors: Alexey Popov, Elizabeth M. Enlow, Hongming Chen, James Bourassa
  • Patent number: 11596600
    Abstract: The invention generally relates to compositions for inducing vasoconstriction. The compositions comprise highly selective alpha-2 adrenergic receptor agonists, at low concentrations, such as below 0.05% weight by volume. The compositions preferably comprise brimonidine. The compositions preferably have pH between about 5.5 and about 6.5.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: March 7, 2023
    Assignee: Eye Therapies, LLC
    Inventor: Gerald Horn
  • Patent number: 11596601
    Abstract: A pharmaceutical mucoadhesive gel composition for delivering therapeutic agents (such as progesterone) by buccal, nasal, vaginal and rectal administration, thereby avoiding the hepatic first-pass metabolism. The gel composition comprises a vehicle with a gel-forming agent and a bioadhesive agent; and a therapeutic agent dispersed or suspended in the vehicle.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: March 7, 2023
    Assignee: Viramal Limited
    Inventors: William Bologna, François Boutignon, Lea Louvel, Finn Larsen, Simona Fiore, Oliver Bates
  • Patent number: 11596602
    Abstract: Provided is a biocompatible material capable of forming a gel having excellent retention and scratch resistance. The biocompatible material according to the embodiment of the present invention includes an alginate having a weight-average molecular weight of 1 million or more, an aluminum compound, a carboxyvinyl polymer, and an oil-based base material. However, the biocompatible material is substantially free of water.
    Type: Grant
    Filed: February 26, 2021
    Date of Patent: March 7, 2023
    Assignee: FUJIFILM Corporation
    Inventors: Haruki Tomikawa, Koji Takaku, Kosuke Chiba, Takafumi Hosokawa
  • Patent number: 11596603
    Abstract: A respirable dry powder including acetylsalicylic acid in particles has a mass median aerodynamic diameter (MMAD) within a range of about 0.5 ?m to about 10 ?m. The respirable dry powder may contain a pharmaceutically acceptable excipient, such as a phospholipid, in an amount ranging from about 0.1% (w/w) to about 10% (w/w) of the particles.
    Type: Grant
    Filed: August 7, 2020
    Date of Patent: March 7, 2023
    Assignee: Vectura Inc.
    Inventor: Kambiz Yadidi
  • Patent number: 11596604
    Abstract: A hydrogen generator electrically coupled to a cloud monitoring system comprises a hydrogen generating device, a monitoring device, a network device, and a controlling device. The monitoring device monitors the machine condition of the hydrogen generating device and generates a condition signal. The network device selectively transmits a machine information including the condition signal to the cloud monitoring system. The controlling device receives an operating parameter from the cloud monitoring system via the network device and controls the hydrogen generating device according to the operating parameter. The hydrogen generator monitoring system of the present invention collects the relevant data of the user using the hydrogen generator and tracks the health status of the user to perform big data analysis.
    Type: Grant
    Filed: July 23, 2019
    Date of Patent: March 7, 2023
    Inventor: Hsin-Yung Lin
  • Patent number: 11596605
    Abstract: The present application provides a method of making a particle comprising (i) obtaining a first solution comprising a negatively charged polysaccharide; (ii) obtaining a second solution comprising a positively charged polysaccharide; and (iii) mixing the first solution and the second solution to obtain a suspension comprising the particle. The present application also provides a method of making a therapeutic particle, comprising: (i) obtaining a solution comprising a therapeutic protein; (ii) obtaining a first suspension comprising the particle comprising a negatively charged polysaccharide and a positively charged polysaccharide, and (iii) mixing the solution of the therapeutic protein and the first suspension to obtain a second suspension comprising the therapeutic particle. The present application also provides particles (e.g.
    Type: Grant
    Filed: August 1, 2017
    Date of Patent: March 7, 2023
    Assignee: The Brigham and Women's Hospital, Inc.
    Inventors: Joseph Loscalzo, Ying-Yi Zhang
  • Patent number: 11596606
    Abstract: An activated cannabinoid controlled release compound tablet and method of forming the same. In one embodiment, the tablet includes a cannabinoid and a hosting compound mixed with the cannabinoid to form a cannabinoid controlled release compound. The tablet may also include a surfactant mixed with the cannabinoid controlled release compound to form an activated cannabinoid controlled release compound.
    Type: Grant
    Filed: May 29, 2020
    Date of Patent: March 7, 2023
    Assignee: METTA MEDICAL INC
    Inventors: Christopher R. Emerson, Christopher M. Antapli, Flip Senn
  • Patent number: 11596607
    Abstract: The present invention is related to polymer based formulation for release of drugs and bioactives at gastrointestinal tract specific sites including stomach, intestine and colon.
    Type: Grant
    Filed: April 10, 2018
    Date of Patent: March 7, 2023
    Assignee: ACTORIOUS INNOVATIONS AND RESEARCH PVT. LTD.
    Inventors: Jayant Jagannath Khandare, Abhijit Gothoskar, Nilesh Kulkarni, Gourishankar Aland, Shashwat Banerjee, Rituja Gupta
  • Patent number: 11596608
    Abstract: The present invention relates a formulation and capsule suitable for oral administration. The invention further relates to the use of the formulation and capsule for treating inflammatory bowel diseases, for instance ulcerative colitis (UC) or Crohn's disease.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: March 7, 2023
    Assignee: Index Pharmaceuticals AB
    Inventors: Paul Alhadeff, Christine Dieterich Johansson, Peter Zerhouni, Wei Tian, Graeme William Andrew Hamilton Johnston
  • Patent number: 11596609
    Abstract: The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36? (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: March 7, 2023
    Assignee: ModernaTX, Inc.
    Inventors: Joshua Frederick, Ailin Bai, Vladimir Presnyak, Stephen Hoge, Kerry Benenato, Iain McFadyen, Ellalahewage Sathyajith Kumarasinghe, Susannah Hewitt
  • Patent number: 11596610
    Abstract: A composition includes a cannabinoid agent in a range of 0.005% to 1%, a terpene agent in a range of 0.005% to 1%, and a co-fermented herbal complex in a range of 5% to 40%. The cannabinoid agent can include CBD, CBN, CBG, or a combination thereof. The composition can further include ashwagandha.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: March 7, 2023
    Assignee: HIGHER OPTIONS GLOBAL, INC.
    Inventor: Jason Crawford
  • Patent number: 11596611
    Abstract: The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: X-A-Y-L-R??(I) which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: March 7, 2023
    Assignee: Enanta Pharmaceuticals, Inc.
    Inventors: Yao-Ling Qiu, Xuri Gao, Jorden Kass, Hui Cao, Wei Li, Xiaowen Peng, Byung-Chul Suh, Yat Sun Or
  • Patent number: 11596612
    Abstract: The present disclosure provides compounds useful as anesthetics, such as topical anesthetics, of general formula (I): wherein: R1 is H, —OMe, Me, or one or more electron withdrawing groups; R2 and R3 are each independently H or alkyl or, taken together, form a 4- to 8-membered heterocyclic ring with the adjacent nitrogen atom; R4 is H or alkyl; R5 is H or one or more electron donating groups; and n is 1 to 4.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: March 7, 2023
    Assignee: PTC Innovations, LLC
    Inventors: Pendleton Wickersham, Stephen Bendel, Todd Mathis, Christian Warren
  • Patent number: 11596613
    Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
    Type: Grant
    Filed: July 31, 2020
    Date of Patent: March 7, 2023
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Michael K. Schultz, Somya Kapoor, Douglas R. Spitz
  • Patent number: 11596614
    Abstract: Treatment of intrahepatic cholestatic diseases by therapy with seladelpar or a salt thereof.
    Type: Grant
    Filed: April 3, 2021
    Date of Patent: March 7, 2023
    Assignee: CymaBay Therapeutics, Inc.
    Inventors: Pol Boudes, Charles A. McWherter
  • Patent number: 11596615
    Abstract: Compounds of Formula (I), and pharmaceutically effective salts thereof; wherein R1-R14, m, n, o, p, q and r are as defined herein, are provided for treatment of for increasing insulin sensitivity, reducing insulin resistance, preventing insulin resistance and treating insulin resistance disorders.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: March 7, 2023
    Assignee: TEMPLE UNIVERSITY—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Salim Merali, Carlos A. Barrero, Wayne E. Childers, George C. Morton
  • Patent number: 11596616
    Abstract: Compositions and methods for inducing weight loss, fat loss, maintaining weight or fat loss, suppressing appetite, reducing calorie intake, reducing weight gain, decreasing feed efficiency, increasing metabolic inefficiency, increasing energy expenditure, increasing thermogenesis and/or resetting metabolic set are disclosed. The compositions have a therapeutically effective amount of a ketogenic supplement, e.g., a ketone diesters, such as R,S 1,3-butanediol diacetoacetate. Compositions of one or more beta-hydroxybutyrate, beta-hydroxybutyrate salt, and medium chain triglycerides are also disclosed.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: March 7, 2023
    Assignee: UNIVERSITY OF SOUTH FLORIDA
    Inventors: Dominic Paul D'Agostino, Angela Marie Poff, Andrew Paul Koutnik
  • Patent number: 11596617
    Abstract: Biologically active cannabidiol analogs comprising a compound of the formula wherein one of R1 or R2 or both is/are the residue of a moiety formed by the reaction of an amino group of the amino acid ester of R1 or R2 or both with a dicarboxylic acid or a dicarboxylic acid derivative and the other R1 or R2 (in the case of the mono) is the residue of a dicarboxylic acid or dicarboxylic acid derivative or Hydrogen (H), (i.e. underivatized), and salts thereof. These CBD analogs are be useful in pain management in oncology and other clinical settings in which neuropathy is presented. Furthermore, these CBD-analogs are useful in blocking the addictive properties of opiates.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: March 7, 2023
    Assignee: UNIVERSITY OF MISSISSIPPI
    Inventors: Mahmoud A. ElSohly, Soumyajit Majumdar, Waseem Gul, Mohammad Khalid Ashfaq, Kenneth Joseph Sufka, Hannah Marie Harris
  • Patent number: 11596618
    Abstract: Oral formulations comprising at least one cannabinoid and at least one mouthfeel experience enhancer are described. For example, methods and materials for preparing a dissolvable lozenge comprising a combination of THC and CBD and Szechuan peppercorn or an extract thereof are provided.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: March 7, 2023
    Assignee: Resurgent Biosciences, Inc.
    Inventors: Eric Greenbaum, Emily Leuer, Nikolaus Goran, Justin Bueno
  • Patent number: 11596620
    Abstract: The invention provides formulations comprising a protein in combination with a compound that prevents oxidation of the protein. The invention also provides methods for making such formulations and methods of using such formulations. The invention further provides methods of screening for compounds that prevent oxidation of a protein in a protein composition and methods of preventing oxidation of a protein in a formulation.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: March 7, 2023
    Assignee: F. HOFFMANN-LA ROCHE AG
    Inventors: Sreedhara Alavattam, Mary Mallaney, Parbir Grewal
  • Patent number: 11596621
    Abstract: The invention relates in part to a method of maintaining heavy metal homeostasis in healthy humans, comprising chronically administering to healthy humans a pharmaceutical composition consisting of from about 1 mg to less than about 200 mg of Posiphen or a pharmaceutically acceptable salt thereof together with one or more pharmaceutically acceptable excipients, on a once a day basis. By virtue of this method, prophylactic treatment of a potential disease state such as a neurodegenerative disease, cardiovascular homeostasis, cancer, vital organ homeostasis, and the like. The invention also relates in part to a method of restoring heavy metal homeostasis in sick patients, comprising chronically administering to a sick patient a pharmaceutical composition consisting of from about 1 mg to less than about 200 mg of Posiphen or a pharmaceutically acceptable salt thereof together with one or more pharmaceutically acceptable excipients, on a once a day basis.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: March 7, 2023
    Assignee: ANNOVIS BIO, INC.
    Inventor: Maria Maccecchini
  • Patent number: 11596622
    Abstract: The present invention relates to mazindol for use in the treatment of dependence and substance use disorder, wherein the substance is an opioid, a composition comprising mazindol and optionally a pharmaceutically acceptable carrier or excipient and/or a diluent, for use in the treatment of substance abuse disorder, wherein the substance is an opioid, and a method of treatment of substance abuse disorder comprising administering mazindol or composition comprising mazindol to a subject, wherein the substance is an opioid. The opioid is preferably heroin.
    Type: Grant
    Filed: September 6, 2018
    Date of Patent: March 7, 2023
    Assignee: NLS Pharmaceutics AG
    Inventor: Alexander C. Zwyer
  • Patent number: 11596623
    Abstract: A method for treating against, or at least inhibiting or suppressing, the proliferation of an internal ribosome entry site-utilizing virus (IRES-utilizing virus) involves administering a compound, a tautomer, or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting replication of the IRES-utilizing virus in cells, wherein the compound is represented by the formula: wherein each R1 is independent of the other and represents a halogen atom selected from the group consisting of bromo, chloro, fluoro and iodo.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: March 7, 2023
    Assignees: HOWARD UNIVERSITY, GEORGETOWN UNIVERSITY
    Inventors: Hemayet Ullah, Sivanesan Dakshanamurthy
  • Patent number: 11596624
    Abstract: The invention provides a crystalline hydrochloride salt of 4-[2-(2,4,6-trifluorophenoxymethyl)phenyl]piperidine. This invention also provides pharmaceutical compositions comprising the crystalline salt, processes and intermediates for preparing the crystalline salt, and methods of using the crystalline salt to treat diseases.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: March 7, 2023
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Lori Jean Patterson, Robert S. Chao, Miroslav Rapta