Abstract: The present invention relates to a biomaterial comprising at least one elastomeric matrix and a polysaccharide, and to uses thereof in the reinforcement, reconstruction and/or filling in of tissue defects, preferably the reinforcement, reconstruction and/or filling in of soft tissue defects and/or epithelial tissues, preferably skin and/or mucosal repair.

Abstract: The dental coating composition of the present invention is suitable to coat dental prosthetics. The composition is a mixture of a (meth)acrylate dimer, a (meth)acrylate crosslinker, a photoinitiator, and a silicone surfactant, and optionally, a (meth)acrylate monomer with a heteroalkyl group, a colorant, special effects pigment, particles, and other additives. Incorporating particles in the dental coating formulation provides a “character” to the surface of the dental prosthetic, increasing the esthetic appeal of the prosthetic. The dental coating thus may make the parts of the dental prosthetic appear to approximate gingivae, or gum. The dental coating composition may be applied to a surface of an unfinished dental prosthesis prior to curing, to a partially cured prosthesis, or fully cured prosthesis.

Abstract: The present invention provides a method of manufacturing a coral scaffold for use as a bone graft substitute. The method comprises growing coral in a growth medium having a carbonate hardness, dKH, of 10 or more; removing at least a portion of the coral from the growth medium; devitalising coral removed from the growth medium and sizing the devitalised coral to form the coral scaffold.

Abstract: A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.

Abstract: Systems, methods, and devices include techniques for generating and using a demineralized bone matrix (DBM)-gelatin matrix allograft material. The DBM-gelatin material can be used to form an implant (e.g., for sternal closure operations) and/or a gel (e.g., for wound/fracture treatment). A method for forming the implant or bone graft can include forming the DBM from an initial bone material; and mixing, in a solution, the DBM with a gelatin carrier to form a DBM-gelatin solution. The gelatin carrier can include an animal-based collagen, such as a porcine-based collagen or a bovine-based collagen. Additionally, the method of forming the bone graft can include performing a crosslinking reaction with the DBM-gelatin solution. The implant can be packaged in a sterile hydration container prior to use.

Abstract: A highly compressible shape memory double network hydrogel includes a first network and a second network interpenetrating with each other. The first network is a chemically crosslinked cellulose by chemical crosslinking, and the chemical crosslinking is accomplished by the formation of ether groups between the cellulose. The second network is a physically crosslinked alginate by physically crosslinking, and the physical crosslinking is accomplished by reaction of the alginate with divalent metal ions. In a preparation process of the highly compressible shape memory double network hydrogel, the cellulose and the alginate are mixed first, the chemical crosslinking is then performed to obtain the first network, followed by the physical crosslinking to obtain the second network.

Abstract: Compositions and methods are provided for lamellar and defect reconstruction of corneal stromal tissue using biomaterials that form a defined hydrogel structure in situ, including interpenetrating (IPN) and semi-IPN hydrogels.

Abstract: There is provided a surface functionalized with cross linking groups adapted to receive antibodies and/or fragments thereof. The surface has an antibody binding biomolecule having a linker region which is covalently crosslinked to functional groups and an antibody binding region. The surface also has a cell interacting biomolecule having a linker region which is covalently crosslinked to functional groups of the surface and a cell interacting region that imparts functional attributes including cell adhesion, spreading, proliferation, differentiation and/or a functional response. The two biomolecules are present in independently controlled concentrations and have similar small molecular weights.

Abstract: Medical products containing hydration mediums, hydration mediums, and methods of making the same.

Abstract: A medical device comprising a surface, wherein a sulfanilamide is associated with the surface, and methods for making the same.

Abstract: Apparatus and methods for concentrating platelet-rich plasma is described herein. One variation may generally comprise a tube having a length and defining a channel within and one or more ports located at a proximal end of the tube and in fluid communication with the channel. A plunger may slidably translatable within the channel while forming a seal against an inner surface of the channel and a float may have a pre-selected density and defining a concave interface surface, wherein the float is slidably contained within the channel such that the concave interface surface is in apposition to the one or more ports.

Abstract: A dialysis system comprising a dialysis machine (100) having a main body portion, a water purification system, the water purification system being separate to the dialysis machine, and a liquid sanitizer (200). The liquid sanitizer (200) is provided within the main body portion of the dialysis machine. The liquid sanitizer (200) is fluidly connected between the dialysis machine (100) and the water purification system. The liquid sanitizer (200) has a heater (240) arranged to heat a volume of liquid, a temperature sensor arranged to sense the temperature of the volume of liquid and a liquid sanitizer controller (250). The dialysis system defines a first closed fluid circuit comprising the dialysis machine and the liquid sanitizer and a second closed fluid circuit comprising the water purification system, the dialysis machine and the liquid sanitizer. The liquid sanitizer (200) is configured to effect sanitization of the first closed fluid circuit and the second closed fluid circuit.

Abstract: A variety of methods and devices for manipulating tissue using stents and shunts that foreshorten when expanded. Many of the devices have ends that expand radially more than a center portion of the device, creating an hourglass or rivet shape that is useful for anchoring the device or putting a squeezing force on the tissue.

Abstract: Device for liposuction comprising: a cannula means; a movement means configured to cause a translational oscillation movement of the cannula means in a movement direction of the cannula means with a frequency smaller than 100 Hz, wherein the movement means is an electro-magnetic actuator configured to cause the translational oscillation movement of the cannula means electro-magnetically, wherein the device comprises a fixed portion and a movable portion, wherein the cannula means is part of the movable portion, wherein the movable portion is supported by the fixed portion movably in the movement direction of the cannula means, wherein the movement means comprises a first magnetic means in the fixed portion and a second magnetic means in the movable portion or connected to the movable portion, wherein one of the first and second magnetic means is an electro-magnetic means powered by electrical power and causing a magnetic field which interacts with the other of the first and second magnetic means to cause the

Abstract: Embodiments of a negative pressure wound closure system and methods for using such a system are described. Certain disclosed embodiments facilitate closure of a wound by preferentially exerting a negative pressure on tissue. Some embodiments may utilize a collapsible sheet with a plurality of cells.

Abstract: A pig cleaning and transportation system is disclosed. Exemplary implementations include a platform with a plurality of apertures; a plurality of securing mechanisms, each mechanism within each aperture and configured to hold a pig and allow it to rotate around its longitudinal axis; a base underneath the platform; and a cleaning element connected to the base and positioned on each longitudinal side of the platform in pressure contact with the pigs on the plurality of securing mechanisms, each cleaning element including at least one cleaning material surface.

Abstract: A medical device that can confirm a predetermined portion in a medical instrument implanted for use in a body. A medical instrument includes a main body part, and a medicinal solution container installed in the main body part. A notification part includes a plurality of light emitting portions that emit light by use of power received by a power receiving part to notify that a predetermined state is reached, when a relative positional relation between a power transmission part and the power receiving part reaches the predetermined state by moving the power transmission part, and a soft part into which an injection needle is inserted, the plurality of light emitting portions are arranged along an outer edge of the soft part. A first coil is a coreless coil disposed to have an inner diameter larger than an outer diameter of the medicinal solution container.

Abstract: An infusion pump assembly includes a reservoir assembly configured to contain an infusible fluid. A motor assembly is configured to act upon the reservoir assembly and dispense at least a portion of the infusible fluid contained within the reservoir assembly. Processing logic is configured to control the motor assembly. A primary power supply is configured to provide primary electrical energy to at least a portion of the processing logic. A backup power supply is configured to provide backup electrical energy to the at least a portion of the processing logic in the event that the primary power supply fails to provide the primary electrical energy to the at least a portion of the processing logic.

Abstract: Methods, system and devices for monitoring a plurality of parameters associated with a closed loop control operation including continuously monitoring a physiological condition and automatic administration of a medication, detecting a signal level associated with the monitored physiological condition deviating from a predetermined threshold level, retrieving the medication level administered associated with a time period of the detected signal level, applying the retrieved medication level to the detected signal based on a predefined predictive model to generate a predictive signal, and comparing the detected signal to the predictive signal to determine whether a condition associated with the detected signal level is present are provided.

Abstract: A drug delivery device for administration to a subject may include a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device may also include a trigger operatively associated with the potential energy source. The trigger may be configured to actuate at a predetermined location within the subject to deploy a jet of the active pharmaceutical ingredient into a tissue of an adjacent portion of the gastrointestinal tract. In some instances, the jet may be deployed into tissue of the stomach and/or small intestine of the subject. Further, in some embodiments, the operating parameters of the jet may be selected such that the jet penetrates the tissue of the gastrointestinal tract to form a depot of the active pharmaceutical ingredient disposed within the tissue.

Abstract: The present disclosure is directed to pharmaceutical packaging such as syringes, vials, and blood tubes having a thermoplastic wall that is coated with a gas barrier coating in which at least one layer is applied by atomic layer deposition. The gas barrier coating may include, for example, one or more layers of SiO2, one or more layers of Al2O3, or a combination thereof, and may serve as a barrier against a variety of gases including oxygen, water vapor, and nitrogen. The present disclosure is also directed to syringes and vials which are configured for the storage of lyophilized or cold-chain drugs and in particular to maintain container closure integrity throughout the supply and storage conditions associated with such drugs. The present disclosure is also directed to evacuated blood tubes having extended shelf lives.

Abstract: The present subject matter relates to semi-automatically controllable syringe (100A-100E, 200, 300, 400, 500, 600, 710, 800A) comprising barrel (102A, 102B, 202, 302, 402), plunger (104, 204, 304, 404, 508, 606), actuating member (116, 124, 206, 306, 406, 510, 608), biasing member (110, 210, 310, 410, 506), and movement control mechanism (118, 120, 218, 314, 418, 516, 618). Actuating member (116, 206, 306, 406, 510, 608) is to move plunger (104, 204, 304, 404, 508, 606). Biasing member (110, 210, 310, 410, 506) biases upon plunger movement in first direction and applies restoring force on plunger (104, 204, 304, 404, 508, 606) towards second direction. Movement control mechanism (118, 120, 218, 314, 418, 516, 618) includes pin-receiving members (118B, 120B, 218B, 314B, 418B, 516B, 618B) and pin (118A, 120A, 218A, 314A, 418A, 516A, 618A) to provide variable limit for plunger movement.

Abstract: A drug delivery device comprises a dose setting and driving assembly for dialing and dispensing a dose of a medicament from a cartridge of the drug delivery device. The dose setting and driving assembly includes an outer housing, a number sleeve and a dose dial grip. The number sleeve and the dose dial grip are rotatable relative to the outer housing during dose dialing. The number sleeve is rotatable relative to the outer housing during dose dispensing. The dose dial grip is axially displaceable and rotationally constrained to the outer housing during dose dispensing. The dose dial grip comprises an outer skirt partially protruding out of the outer housing and comprising a profiled gripping surface at the proximal end of the dose dial grip.

Abstract: The invention relates to a computer-controlled injector, comprising: a housing configured to receive a medicament cartridge; an injection drive mechanism comprising a computer-controlled motor for driving a piston within said medicament cartridge, for injecting the medicament; a data tag attachable to said medicament cartridge; and an electromagnetic detector disposed within said housing and being connectable to the data tag upon mounting of said medicament cartridge into said housing, said electromagnetic detector permitting data to be read from or written to said data tag. The electromagnetic detector is configured to read or write data irrespectively of a rotational orientation of said medicament cartridge within said computer-controlled injector.

Abstract: Disclosed is a method and an auto-injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a resistance sensor configured to provide a resistance signal indicative of resistance against movement of the plunger rod; and a processing unit coupled to the drive module and to the resistance sensor.

Abstract: Apparatus and method for syringe support are disclosed. The syringe-support apparatus may include a front arm and a back arm connected at a hinge mechanism. The front and back arms may comprise a finger grip and thumb grip. A user may employ a well-known scissor-like movement in view of the finger grip and thumb grip, combined with the hinge mechanism. The front and back arms may further comprise a syringe securing mechanism, which may correlate hand motion with a syringe plunger motion. In view of the finger grip, thumb grip, and syringe securing mechanism, respectively, a user may engage the user's forearm muscles during aspiration and injection. The securing mechanism may comprise an adjustable barrel support and barrel support hook to secure a syringe barrel.

Abstract: A rigid needle shield for a syringe includes a main body comprising an internal sidewall defining a bore, and an end cap attached to the main body. The end cap includes at least one frangible tab connected to the sidewall of the main body. The rigid needle shield further includes an elastomeric insert extending through the bore and engaging the end cap. The at least one frangible tab is configured to break from the internal sidewall and advance through the bore upon application of a force to the end cap.

Abstract: A syringe and detachable needle assembly having reduced dead space features includes an elongate syringe barrel having open distal end including a collar and a distally facing annular surface projecting inwardly from the collar. A needle assembly includes a hub having a proximally facing annular surface and an outwardly projecting annular sealing ring positioned distally from the surface. The needle assembly also includes a cannula having a lumen therethrough connected to the distal end of the hub. Structure is provided for engaging the hub to the barrel resulting in the annular surface of the barrel contacting the annular surface of the hub to form a primary seal between said barrel and said hub and the annular sealing ring contacting the collar to form a secondary seal between the barrel and the hub.

Abstract: A portable nebulizer provided by the invention is particularly suitable for using with a liquid contained in a capsule or in a container made of a disposable material that can be easily damaged, the portable nebulizer comprises a driving unit for driving an atomizing unit, and a containing unit for containing the container, the containing unit has a breaking part for breaking the container to facilitate outflow of the liquid, after the liquid flows into an inner space of a main body of the containing unit because the container is damaged by the breaking part, the liquid can be atomized by the atomizing unit to produce a mist capable of escaping to the outside of the main body for a user to use the liquid mist conveniently.

Abstract: This invention relates to a compliance monitor for monitoring patient usage of a medicament delivery device, where the medicament delivery device includes a store of medicament and a medicament dispensing means. The compliance monitor includes a housing adapted to enclose the medicament delivery device, and a dose counter, associated with the housing, for recording the delivery of a dose of medicament to the patient from the medicament delivery device. The arrangement and construction is such that the housing is loosely coupled to the medicament delivery device, whereby the housing is able to move relative to the medicament delivery device during the delivery of the dose of medicament, and it is this movement which actuates the dose counter, either directly or indirectly, in order to record the delivery of the dose of medicament.

Abstract: A mist inhaler device (200) for generating a mist for inhalation by a user. The device includes a mist generator device (201) and a driver device (202). The driver device (202) is configured to drive the mist generator device (201) at an optimum frequency to maximise the efficiency of mist generation by the mist generator device (201).

Abstract: Some embodiments of an inhalation exposure system can deliver a gas, such as an aerosol, through a manifold to a set of exposure chambers in a controlled manner so as to achieve improved consistency for all of the test subjects.

Abstract: A collapsible spacer for use with a metered-dose-inhaler (MDI) medicament cartridge the spacer being movable between an expanded configuration for operation of the spacer and a collapsed configuration for transport or storage of the spacer. The spacer includes: an internal chamber for receiving a medicament dose when the spacer is in the expanded configuration and a cartridge dock for, in use, engaging with an MDI cartridge and permitting delivery of a medicament dose from the MDI cartridge to the internal chamber. The spacer further includes a mouthpiece permitting inhalation of a medicament dose from the internal chamber and a storage volume configured to accommodate the cartridge dock and an MDI cartridge. The cartridge dock is retractable into the storage volume in a retraction direction to store the MDI cartridge within the storage volume whilst maintaining engagement between the MDI cartridge and the cartridge dock.

Abstract: A system that atomizes one or more plant essences, botanical fluids, isolates, and other plant distillates to be administered by inhalation is provided. The system generally comprises a fluid, distributer, computing entity, processor operably connected to the computing entity and distributer, and non-transitory computer-readable medium coupled to the processor. Air furnished by the air supply may move through the manifold and into the cartridge where it is manipulated into a stream of fast-moving air. This stream of fast-moving air is then combined with fluid within the cartridge to create atomized fluid, which moves through the cartridge to an atomization outlet where it is dispersed within the environment. In some embodiments, a user may control the system via a user interface of the computing entity.

Abstract: The present disclosure relates to aerosol delivery devices, methods of forming such devices, and elements of such devices. In some embodiments, the present disclosure provides atomizers and elements thereof, such as a combined wick and heater configured to improve vaporization response time, particularly on porous, monolithic wicks. The wick can have a tapered end that engages the interior of a substantially basket-shaped wire heater coil. The heater also may be in the form of a conductive mesh that is present on a portion of the wick.

Abstract: Various exemplary drug delivery devices with on-board drug destruction, drug products utilizing the same, and methods of using drug delivery devices with on-board drug destruction are provided. In general, a nasal drug delivery device configured to dispense a drug therefrom into a nose includes a destruction mechanism configured to destroy drug contained in the drug delivery device. The destruction mechanism can be configured to destroy the drug before a first actuation of the drug delivery device to deliver the drug therefrom such that the destruction mechanism destroys substantially all of the drug contained in the drug delivery device. Alternatively or in addition, the destruction mechanism can be configured to destroy the drug after a first actuation of the drug delivery device to deliver the drug therefrom such that the destruction mechanism destroys substantially all of the drug remaining in the drug delivery device.

Abstract: A method of, or system for, ventilating lungs in breathing and non-breathing patients—including applications for anesthesia—may comprise maintaining an inspiratory flow rate at an inspiratory setpoint at a low flow setting. Lung pressure in a patient may be regulated between a high pressure setpoint and a low pressure setpoint with periodic expiratory flows and continuous inspiratory flow. An expiratory control valve may be adjusted to an open position when a lung pressure is at or above a high pressure setpoint. An expiratory control valve may be adjusted to a closed position when a lung pressure is at or below a low pressure setpoint. Concurrent venting outflow and CO2 offloading through flow within the lungs may be facilitated by providing an intermittent expiratory flow to the patient while providing the continuous inspiratory flow.

Abstract: Described herein is a respiratory care apparatus capable of performing multitude of therapy for secretion management and breath assistance therapy. The respiratory care apparatus comprises an electromechanical air router assembly (EARA) and an interfacing assembly. The EARA includes independent first and second pressure generating sources for assisted inhalation/insufflation and assisted exhalation/exsufflation process. The interfacing assembly includes a patient interface port and a patient interface tube. The interfacing assembly forms two pneumatically separate paths. The respiratory care apparatus is configured to generate alternate positive and negative pressure at the patient interface port for assisted inhalation/insufflation and assisted exhalation/exsufflation processes respectively. The assisted inhalation/insufflation and assisted exhalation/exsufflation processes are carried out independently through separate conduits/passages to reduce contamination and infection.

Abstract: The nebulizer gas scavenging system includes a condenser positioned in the expiratory pathway of the breathing circuit for extracting liquid from expiratory gases and redirecting the extracting liquid to the input of the nebulizer. The system is further configured to detect the actual consumption of inhaled medication by measuring the concentration of medication in the expiratory pathway and comparing it to the initial content of medication in the aerosol of the inspiratory pathway. A more accurate determination of the amount of inhaled medication is advantageous in certain critical situations involving application of medication by inhalation.

Abstract: An emergency ventilator for artificially ventilating patients in the event of a medical emergency, including: - a housing with an ambient air suction opening and a ventilating gas outlet opening, - a fan which is designed and is arranged in the housing so as to convey ambient air from the ambient air suction opening to the ventilating gas outlet opening, - an air filter which is designed to purify suctioned ambient air and which is arranged in the housing downstream of the ambient air suction opening in the flow path of the ambient air, and - an energy storage device for supplying the fan with energy in order to operate same, wherein the air filter is received in the housing in an accessible manner through a housing opening, which is closed but can be opened by a housing cover, and so as to be replaceable in an intended manner, and the energy storage device is received in the housing in an accessible manner through the housing opening, which is closed but can be opened by the housing cover, and so as to be re

Abstract: A compact respiratory therapy device suitable for use by a patient during sleep to provide respiratory pressure therapy such as at a pressure between 4-30 cmH2O includes a housing, an inlet, an outlet, a motor including a rotor, and an impeller configured to be rotated by the rotor to deliver a flow of air from the inlet toward the outlet. The impeller includes a set of impeller blades, each impeller blade comprising a leading edge and a trailing edge; and a first shroud and a second shroud, each shroud at least partly defining a flow passage through the impeller, the first shroud comprising a wall defining a periphery of an impeller inlet. The compact respiratory therapy device is configured to deliver the flow of air from the outlet for delivery to the patient at a pressure between 4-30 cmH2O at an overall sound power level of less than 50 dB(A) thereby reducing any disturbance to a quality of sleep for the patient. A diameter of the impeller is less than 50 mm.

Abstract: In accordance with the present invention, there is provided an adaptor or attachment which is suitable for integration into the patient circuit of a ventilation system, such as a non-invasive open ventilation system, is configured for attachment to any standard ventilation mask, and is outfitted with a jet pump which creates pressure and flow by facilitating the entrainment of ambient air. The adaptor comprises a base element and a nozzle element which are operatively coupled to each other. The base element further defines a throat and at least one entrainment port facilitating a path of fluid communication between the throat and ambient air. The nozzle element includes a jet nozzle, and a connector which is adapted to facilitate the fluid coupling of the nozzle element to a bi-lumen tube of the patient circuit. The connector includes both a delivery port and a sensing port.

Abstract: An anesthesia machine, anesthesia control method and system are provided. The anesthesia machine controls the infusion device, or the control terminal controls the anesthesia machine and infusion device, such that the doctor controls the inhalation and intravenous infusion of anesthetics for patient with only one device, without walking back and forth between multiple devices, which improves the efficiency of anesthesia control.

Abstract: A pulmonary isolation and ventilation apparatus (e.g., device, system, etc.) is disclosed. The apparatus may include a controller, a steerable outer member (e.g., outer sleeve body), configured to hold an inner member (e.g., endoscope) and a handpiece. The apparatus may be configured as a sleeve for use with any inner member or the apparatus may include the inner member. Through the handpiece, a user may position the outer sleeve body over an endoscope within a target region of the lungs. The position may be verified by the user using a camera of the endoscope. The endoscope may be removed without disrupting the lungs and the positioning within the lungs. The apparatus may provide improved ventilator functionality to the identified region of the lungs through outer member and may provide for isolating a selective targeted area of the lungs for treatment.

Abstract: Device, systems, and methods relating to a mask interface are disclosed. For example, a mask interface may include a body and an interface coupled to the body. The body may include a nasal portion including an opening and a mouth portion including an open channel. The interface may be in contact with a subject’s face and may include a flexible material conformable to the subject’s face.

Abstract: A patient interface comprising a plenum chamber configured to receive in use a flow of air at the therapeutic pressure for breathing by a patient, a seal-forming structure configured to form a seal with or around the patient's nose and/or mouth, a positioning and stabilising structure configured to hold the seal-forming structure in a sealing position, and at least one inflatable body. In one form, an inflatable body is provided to a portion of the positioning and stabilising structure. In another form the inflatable body is provided to a hoop structure. In another form, the patient interface comprises a lever arrangement, wherein an inflatable body is provided to the lever arrangement. In yet another form, the seal-forming structure comprises an inflatable body.

Abstract: A respiratory mask includes a frame and a cushion module. The frame can include a front wall having a vent and/or a gas inlet opening and a collar extending away from the front wall. The collar surrounds the vent and/or the gas inlet opening. The cushion module comprises a cushion and a housing, which is made of a material more rigid than the cushion. The housing defines a connection opening. A friction coupling selectively couples the cushion module to the frame and comprises an elastomeric friction member coupled to a portion of the housing that defines the connection opening. In some arrangements, an outer surface of the friction member is exposed when the cushion module is coupled to the frame. In some arrangements, the housing extends through the peripheral surface.

Abstract: Methods and apparatus for automated detection of an airway device coupled to an automatic rescue breathing unit (ARBU) are disclosed. The automatic detection apparatus includes a keying system that utilizes color adapters coupled to specific airway devices to indicate to a controller that the airway device is a particular size and has a particular airway protection classification (e.g., protected or unprotected). The controller may then determine the proper rescue breath rate and volume (e.g., tidal volume) based on knowing the size and classification of the airway device. In some instances, the controller may also receive information on chest compressions applied to the patient. Automatic detection of the size and classification of the airway device, along with chest compressions, may improve the process of providing automated rescue breaths to a patient.

Abstract: The invention relates to a connection member configured to connect an air circuit to a patient interface to convey a flow of pressurised breathable gas. The connection member comprises: first and second tube portions configured to connect to a patient interface and air circuit respectively; an anti-asphyxia valve (AAV); and a vent for venting gas exhaled by the patient to the ambient air. The vent is formed between the first and second tube portions. The first tube portion may have a substantially straight first longitudinal central axis and the second tube portion may have a substantially straight second longitudinal central axis that is substantially straight, the first tube portion and the second tube portion being arranged with the first longitudinal central axis substantially parallel to the second longitudinal central axis. The AAV is located in a position on the connection member closer to the patient interface than the vent.

Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.