Abstract: A method for visualizing details in a sample including directing an excitation beam to an excitation location below a surface of the sample, to generate signals in the sample; directing an interrogation beam toward the excitation location of the sample; directing a signal enhancement beam to the sample, to raise a temperature of a portion of the sample by 5 Kelvin or less, compared to a temperature of the portion of the sample in absence of the signal enhancement beam; detecting a portion of the interrogation beam returning from the sample that is indicative of the generated signals.

Abstract: Human mesh model recovery may utilize prior knowledge of the hierarchical structural correlation between different parts of a human body. Such structural correlation may be between a root kinematic chain of the human body and a head or limb kinematic chain of the human body. Shape and/or pose parameters relating to the human mesh model may be determined by first determining the parameters associated with the root kinematic chain and then using those parameters to predict the parameters associated with the head or limb kinematic chain. Such a task can be accomplished using a system comprising one or more processors and one or more storage devices storing instructions that, when executed by the one or more processors, cause the one or more processors to implement one or more neural networks trained to perform functions related to the task.

Abstract: There is described a pressure guidewire. It comprises a sensor housing and a sensor assembly embedded in the sensor housing and comprising a pressure sensor. There is a band to support the pressure sensor assembly, the band being embedded inside the sensor housing and fixed to the pressure sensor assembly for holding the pressure sensor inside the sensor housing.

Abstract: A method is disclosed for diagnosing and treating a patient having lesions in both arteries of left and right lower limbs. By determining that a lower stenosis rate lesion to be treated first, catheters and an operation time can be reduced is to be treated first on a priority basis based on diagnostic data, deciding that a higher stenosis rate lesion is to be treated next, then treating the lesions substantially continuously.

Abstract: A system and method for monitoring a patient suspected of experiencing a state of unconsciousness are provided. In certain aspects, the method includes assembling physiological data, obtained from a plurality of sensors placed on a subject, into sets of time-series data, separating, from the sets of time-series data, a plurality of electroencephalogram signals, and determining, from the plurality of electroencephalogram signals, at least one of frequency information and amplitude information. The method can also include identifying, using the at least one of the frequency information and the amplitude information, spatiotemporal signatures indicative of a likelihood of arousing the patient to consciousness by applying an external stimulus and generating a report indicating the likelihood of arousing the patient to consciousness by applying the external stimulus.

Abstract: Embodiments of the present technology may include a system for monitoring a health parameter of a person, the system including an interface configured to receive data that corresponds to a digital pulse wave signal that is generated from radio frequency data and that corresponds to radio waves that have reflected from below the skin surface of a person. In some embodiments, the radio frequency data is collected through a two-dimensional array of receive antennas. Embodiments may also include a processor configured to determine a value that corresponds to a blood glucose level in the person in response to the data that corresponds to the digital pulse wave signal.

Abstract: A fluid pressure detection device capable of accurately detecting a pressure change of a fluid flowing inside a tube includes a substrate, a piezoelectric element formed on the top surface of the substrate, a support body which is annular and surrounds the piezoelectric element and supports the top surface of the substrate, and a lid body which is provided to close the top opening of the support body, and deforms the tube with the bottom surface of the substrate by pressing the substrate through the support body.

Abstract: A blood pressure information measurement device, including first and second fluid bags in the first fluid bag; a pressure mechanism increases/decreases pressure in an internal space of the first fluid bag and the pressure in the internal space of the second bag; a control unit controls operation of the pressure mechanism; a pressure detection device detects an internal pressure of the first and the second fluid bag; and a calculation unit that calculates blood pressure information detected by the device. In calculating blood pressure information, the control unit controls operation of the pressure increase/reduction mechanism after the internal space of one fluid bag of the first and second fluid bags pressurized and expanded until internal pressure of one fluid bag reaches a predetermined pressure, the internal space of the other fluid bag of the first and second fluid bags pressurized and expanded while the one bag is kept sealed.

Abstract: There is provided an information processing apparatus including a reliability degree calculation section that calculates a reliability degree of pulsation variability data or a body index; and a control unit that controls various kinds of processing on the basis of the calculated reliability degree. The pulsation variability data is acquired from sensing data acquired by a pulse wave sensor worn by a user. The body index is calculated from the pulsation variability data and indicates a physical state of the user.

Abstract: This disclosure relates to methods for measuring one or more physiological signals while the user is engaged in a predetermined activity. Exemplary predetermined activities can include activities such as walking, climbing stairs, biking, and the like. The physiological measurements can include, but are not limited to, heart rate signals. The physiological measurements may be affected by the predetermined activity, so the system may be configured to employ one or more criteria prior to measuring physiological information to minimize the effects. The one or more criteria can include, but are not limited to, an inter-sampling waiting time, continuous motion criteria, predetermined activity criteria, a post-physiological measurement amount of time, and a confidence value. The continuous motion criteria can be based on the type of predetermined activity. For example, walking may have walking state criteria and a step count criteria.

Abstract: A system for facilitating arterial blood gas (ABG) sampling. The system includes a main part, a first plurality of pulse sensors attached in a row on an inner surface of the main part, a first plurality of lights attached in a row on an external surface of the main part, a first opening on the main part adjacent to the first plurality of pulse sensors, and a processor. The processor is configured to receive a first plurality of radial pulse intensities from the first plurality of pulse sensors, determine a highest radial pulse intensity among the first plurality of radial pulse intensities, and turn on a light from the first plurality of lights associated with the highest pulse intensity among the first plurality of radial pulse intensities.

Abstract: An electronic device can include a housing defining an aperture and at least partially defining an internal volume of the electronic device, an electromagnetic radiation emitter and an electromagnetic radiation detector disposed in the internal volume, and an optical component disposed in the aperture. The optical component can include a first and second transparent portions disposed above the electromagnetic radiation detector and the electromagnetic radiation emitter, and an opaque portion disposed between the first and second transparent portions and extending a thickness of the optical component. The first transparent portion, the second transparent portion, and the opaque portion can define a flush exterior surface of the electronic device.

Abstract: Devices and methods for determining fluid flow resistance at a targeted location in a bodily fluid vessel by monitoring changes in pressure gradients across the location while fluid flow is being manipulated by introducing infusate into the target area at different rates.

Abstract: Enteral tubes, tube tip detection systems, and methods for detecting tube misplacement are provided. For example, a tube tip detection system comprises an enteral tube having a tip and a first light disposed at the tip that is illuminated as the enteral tube is inserted into a patient to indicate to a user of the system whether the tip is misplaced in the patient's airway. Similarly, enteral tubes are provided that comprise a tip, a length, and a light that is continuously illuminated as the enteral tube is inserted into a patient. Methods for detecting a tube misplacement in a patient's airway include embedding a light into an enteral tube, inserting the enteral tube into the patient through the patient's nose or mouth, and monitoring a location of the light as the enteral tube is inserted into the patient to determine if the tube is traveling into the patient's airway.

Abstract: Ingestible radio frequency identification (RFID) tags are disclosed. A system embodiment includes, but is not limited to, an RFID tag including a flexible substrate foldable between a planar configuration and a tubular configuration, a conductive element disposed on the flexible substrate, and an RFID tag chip electrically coupled with the conductive element; a capsule structured and dimensioned for ingestion by a biological subject, the capsule including a shell structured and dimensioned to enclose a medication for the biological subject simultaneously with the RFID tag when the flexible substrate is in the tubular configuration, but not when the flexible substrate is in the planar configuration; and a pH switch structure coupled to an exterior surface of the capsule, the pH switch configured to deactivate the RFID tag in a first configuration and to permit activation of the RFID tag in a second configuration within the biological subject.

Abstract: An active medical device, comprising a processor, a memory unit, and at least one of an accelerometer and a detection unit configured to detect a body impedance. During operation, the active medical device carries out the following steps: a) measuring a body impedance of a patient with the detection unit during a first period of time to obtain time-dependent impedance data and calculating a power spectral density of the impedance data; b) alternatively or additionally to step a), measuring an acceleration of a body of the patient with the accelerometer during the first period of time to obtain time-dependent acceleration data and calculating a power spectral density of the acceleration data; c) identifying coughing of the patient on the basis of the calculated power spectral density if at least 1% of all values of the power spectral density have a frequency of at least 1 Hz.

Abstract: Methods may be provided to identify a medical implant from a plurality of medical implants to be fixed to an anatomical surface. Dimensional parameters for each of the plurality of medical implants may be provided, and dimensional parameters corresponding to the anatomical surface may be provided. The dimensional parameters for each of the plurality of medical implants may be compared with the dimensional parameters corresponding to the anatomical surface, and one of the medical implants may be selected from the plurality of medical implants based on comparing the dimensional parameters for each of the plurality of medical implants with the dimensional parameters corresponding to the anatomical surface. An identification of the medical implant selected from the plurality of medical implants may be provided through a user interface. Related devices and computer program products are also discussed.

Abstract: The invention includes a system to determine body surface area (BSA) or volume of an animal that can be used to determine a health status of the animal. The system has a plurality of integrated measuring devices such as radar or infrared sensors. The measuring devices are mounted within a confined space. A plurality of measurements is taken along vertically oriented sections or slices of the animal as the animal passes by the confined space. The measurements are combined and numerically converted to BSA or volume estimations. The health status can be derived as a direct relation to BSA or volume, or changes in BSA or volume over a selected time period.

Abstract: A wireless hub includes a vehicle power connector that can draw power from a vehicle battery on a vehicle, a first wireless transmission circuit that can send or receive data with base stations in a long-range wireless network, a second wireless transmission circuit that can provide a short-range wireless network and to transfer data to and from electronic devices, and a network processor that can process data in the first wireless transmission circuit and the second wireless transmission circuit. The wireless hub has an antenna array for millimeter wave communications.

Abstract: Aspects describe capturing the dynamic movement of one or more leaders and generating stimulus signals in real time for one or more followers to perform substantially the same movement. A model of each follower is optionally employed to transform the observed movement of a leader to a series of movement cues that will overcome any follower physical and cognitive limitations while maximizing the movement compliance and benefit from the directed movement. Also provided is the capability of establishing a library of therapeutic, fitness, rehabilitation or dance movement scripts that may be replayed at the follower's convenience without a leader present. Additionally, one aspect provides for continually monitoring follower movement to detect unstable movement, an increased likelihood of a fall and gait anomalies and initiating a stimulus pattern to reduce the chance of a fall or injury.

Abstract: A fully autonomous system is used to diagnose an ear infection in a patient. For example, a processor receives patient data about a patient, the patient data comprising at least one of: patient history from medical records for the patient, one or more vitals measurements of the patient, and answers from the patient about the patient's condition. The processor receives a set of biomarker features extracted from measurement data taken from an ear of the patient. The processor synthesizes the patient data and the biomarker features into input data, and applies the synthesized input data to a trained diagnostic model, the diagnostic model comprising a machine learning model configured to output a probability-based diagnosis of an ear infection from the synthesized input data. The processor outputs the determined diagnosis from the diagnostic model. A service may then determine a therapy for the patient based on the determined diagnosis.

Abstract: The present invention concerns a method for the detection of distortion products of otoacoustic emissions (DPOAE), comprising the steps: (a) output of at least one first pair of primary tones each consisting of a first primary tone with frequency f1,1 and sound pressure level L1,1 and a second primary tone with frequency f2,1 and sound pressure level L2,1 with f2,1>f1,1, and (b) detecting evoked distortion products of otoacoustic emissions (DPOAE), characterized in that the first primary tone {f1,1, L1,1} is output with a time delay tlag after the second primary tone {f2,1, L2,1}.

Abstract: There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (1) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Abstract: An apparatus for obtaining a target signal spectrum includes: a spectrum measurer configured to measure a plurality of spectra from an object; and a processor configured to obtain a difference spectrum matrix by subtracting a reference spectrum from each of the plurality of spectra, and to obtain a spectrum of a target signal based on the obtained difference spectrum matrix.

Abstract: An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.

Abstract: A wearable sensor system includes a flexible patch, an electronic circuit disposed on the flexible patch, and a disposable sensor disposed on the flexible patch and connected to the electronic circuit via a socket. The disposable sensor detects a chemical compound. The electronic circuit generates a detection signal commensurate with the chemical compound detected by the disposable sensor. The disposable sensor is removably plugged into the socket, thereby permitting replacement of the disposable sensor upon satisfaction of a predetermined condition. A battery disposed is on the flexible patch and connected to the electronic circuit to power the electronic circuit. A transceiver is connected to the electronic circuit, wherein the transceiver transmits the detection signal.

Abstract: A biosensing device includes a sensor module and an electric signal transducer. The sensor module includes a biosensor adapted for measuring a biosignal of a host, and a fixed seat including a conducting member that is electrically connected to the biosensor. The electric signal transducer is for receiving and sending the biosignal measured by the biosensor, is coupled to the sensor module, and includes an electric signal unit electrically connected to the conducting member, and a battery connected to the electric signal unit. The electric signal unit has two electrical contacts that cooperatively define a switch. The battery provides power supply to the biosensor when the electric signal transducer is coupled to the sensor module.

Abstract: An apparatus includes a housing that defines a fluid reservoir and includes a port that is in fluid communication with the fluid reservoir. An inlet adapter is removably coupleable to the housing. A user can engage an actuator to move a plunger from a first position in which the fluid reservoir has a first volume, to a second position in which the fluid reservoir has a second volume greater than the first volume, which draws bodily fluid into the fluid reservoir via the inlet adapter. The actuator modulates a plunger rate of motion below a threshold as the plunger is moved. When a predetermined volume of bodily fluid is transferred into the fluid reservoir, a volume indicator transitions from a first state to a second state and the inlet adapter can then be removed to transfer the predetermined volume into a sample bottle external to the housing via the port.

Abstract: According to an aspect, there is provided an apparatus for use in detecting malingering by a first subject in a test of physical and/or mental function of the first subject.

Abstract: A method for the automatic execution of a Static Dynamic Personality Test (TPSD) of a person, the method involving use of a cubic-spherical container obtained by merging concentrically a cube and a sphere. The method includes taking images of the person and overlapping the cubic-spherical container to the images, and measuring static-dynamic positions of the person as depicted in the images with respect to the cubic-spherical container.

Abstract: A bladder fullness monitoring systems includes a controller and an active optical sensor that is affixed to a patient's bladder. The sensor emits light onto the bladder and further detects light reflected from the bladder, in order to generate an output signal that indicates an amount of emitted light was reflected back to the detector. The controller is coupled to the optical sensor to receive and interpret the output signals, e.g., to determine when the bladder is full. The controller may be operatively coupled to a urinary control apparatus which uses the output signals to trigger urination in patients who have lost the ability to voluntarily urinate. Embodiments are particularly useful for monitoring bladder fullness in patients who have lost bladder sensation and/or the ability to voluntary urinate and rely on a urinary control apparatus in order to urinate.

Abstract: A self-authenticating electrocardiography and physiological sensor monitor is provided. A strip includes two rounded ends with a mid-section between the rounded ends. An electrocardiographic electrode is provided on each of the rounded ends. A flexible circuit is mounted to a surface of the strip and includes a circuit trace electrically coupled to each of the electrocardiographic electrodes. A flash memory is positioned on one of the rounded ends to store ECG data collected via the electrocardiographic electrodes and a battery is positioned on one of the rounded ends. A processor is positioned on one of the rounded ends and configured to execute an authentication protocol that checks voltage of the battery and a state of the flash memory, and determines an expiration of the strip.

Abstract: The present invention provides a bio-electrode composition comprising a polymer compound having a repeating unit A that contains silver salt of fluorosulfonic acid, silver salt of fluorosulfonimide, or silver salt of fluorosulfonamide. This can form a living body contact layer for a bio-electrode with excellent electric conductivity, biocompatibility and light weight, which can be manufactured at low cost and does not cause large lowering of the electric conductivity even when it is wetted with water or dried. The present invention also provides a bio-electrode in which the living body contact layer is formed from the bio-electrode composition and a method for manufacturing the bio-electrode.

Abstract: A glove comprising a set of electrocardiogram leads, the set of electrocardiogram leads including: (a) a plurality of precordial electrocardiogram leads; (b) a pair of aVL and aVR electrocardiogram leads; and (c) an aVF electrocardiogram lead; wherein the glove records a 12-lead electrocardiogram by pressing the glove against skin of a user.

Abstract: Provided is an electrode sheet allowing easy connection of a wiring that is extended, when required, to a measurement position on a living body. The electrode sheet (main sheet (1), auxiliary sheet (10)) includes a sheet-shaped flexible substrate (2, 11), wirings (3, 12) formed on the flexible substrate (2, 11), electrodes (5, 14) formed on the flexible substrate (2, 11) and electrically connected to the wirings (3, 12), and an insulating layer (4, 13) laid on the flexible substrate (2, 11) in such a manner that the wirings (3, 12) are overlaid with the insulating layer (4, 13) while the electrodes (5, 14) are exposed. The electrodes (5, 14) are formed of a conductive material in which conductive particles are dispersed in a thermoplastic resin.

Abstract: A system and method may be provided for associating bio-signal data (e.g. EEG brain scan data) from at least one user with at least one music data item (e.g. song, or piece of music). By associating bio-signal data, or emotions determined therefrom, with music, the system may establish a data store of music associated with emotions. That database may then be leveraged upon determining that a user is feeling a particular emotion through an EEG scan. When a particular emotion is detected in EEG data of a user, the system may then respond based at least partly on the same or similar emotion being associated with one or more music data items in the system. For example, the system may recommend a particular song associated with the same emotion presently being experienced by the user.

Abstract: The present disclosure relates to an apparatus (100) for quantitative assessment of olfactory dysfunctions and neurocognitive deficits, the apparatus includes first filters (104-1) adapted to sterilize air received from an air pump, a second filter (106) filter odor molecules from the air, a manifold (108) adapted to split the sterilized air into a plurality of channels, at least one channel carries the sterilized air to a first MFC (110) and adjacent channels carry sterilized air to second MFCs (112). Each container in a reservoir (114) filled with an odorant different from adjacent containers, and a nozzle (118) adapted to receive the odorized air from the reservoir that is inhaled by a subject through an odor delivery unit (124), based on degree of variation in volumetric concentration of the odorants, quantitative assessment of olfactory dysfunction is determined.

Abstract: A physiological state determination device determines a predetermined physiological state of a subject. The physiological state determination device includes a brain function activation information detection unit, a face change information acquisition unit, and a physiological state determination unit. The brain function activation information detection unit detects brain function activation information corresponding to a physiological state. The face change information acquisition unit acquires face change information indicating a time-series change in face data of a subject. The physiological state determination unit determines the predetermined physiological state of the subject based on the brain function activation information and the face change information.

Abstract: A system and method for modeling patient-specific spinal cord stimulation (SCS) is disclosed. The system and method acquire impedance and evoked compound action potential (ECAP) signals from a lead positioned proximate to a spinal cord (SC). The lead includes at least one electrode. The system and method determine a patient-specific anatomical model based on the impedance and ECAP signals, and transform a dorsal column (DC) map template based on a DC boundary of the patient-specific anatomical model. Further, the system and method map the transformed DC map template to the patient-specific anatomical model. The system and method may also include the algorithms to solve extracellular and intracellular domain electrical fields and propagation along neurons. The system and method may also include the user interfaces to collect patient responses and compare with the patient-specific anatomical model as well as using the patient-specific anatomical model for guiding SCS programming.

Abstract: One embodiment provides a method, including: obtaining EEG data from one or more single channel EEG sensor worn by a user; classifying, using a processor, the EEG data as one of nominal and abnormal; and providing an indication associated with a classification of the EEG data. Other embodiments are described and claimed.

Abstract: The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

Abstract: An apparatus has a computer receiving input signals indicative of fetal heart rate (“FHR”) and maternal uterine activity in a patient. The computer determines when each of FHR, baseline FHR variability, FHR accelerations, FHR decelerations, and maternal uterine activity exhibit a plurality of pre-defined non-reassuring characteristics. The computer receives inputs indicating the presence of maternal, obstetrical, and fetal risk factors, and determines at predetermined times during labor a present level of risk to the fetus which accounts for the total of the number of parameters that each exhibit the non-reassuring characteristics at predetermined points in time during labor and the number of risk factors present. An output display depicts in a single graphical interface information respecting the parameters and risk factors over time during labor.

Abstract: Nanomaterial epidermal sensors can be adhered to the skin and worn comfortably and inconspicuously for days to allow for repeated biometric sensing. The nanomaterial epidermal sensors may be comprised of a monolayer of graphene coating a flexible polymer substrate. Various nanomaterial epidermal sensors may be quickly fabricated using a cost-efficient “cut-and-paste” method on transfer paper and can be adhered directly to skin without tape or adhesive, much like a temporary-tattoo. The nanomaterial epidermal sensors may be optically transparent and may be used to measure an electrocardiogram (ECG), an electroencephalogram (EEG) or an electromyogram (EMG) with a signal-to-noise ratio that is comparable to conventional electrodes. In addition, the nanomaterial epidermal sensors may be used to measure other parameters, such as skin temperature or skin hydration.

Abstract: The present invention provides an articulation evaluation method and system combining acoustic features and articulation motion features. According to the articulation evaluation method and system, audio data and articulation motion data are acquired, acoustic features are extracted from the audio data, articulation motion features are extracted from the articulation motion features, and feature fusion and policy fusion are performed on the acoustic features and the articulation motion features according to a time correspondence, which effectively utilizes the complementarity of the two types of features to ensure the objectivity and comprehensiveness of evaluation, so that a more accurate and reliable feature fusion evaluation result and decision fusion evaluation result are obtained, making the articulation evaluation more objective and accurate.

Abstract: The present disclosure discloses a method, device, apparatus, and storage medium for sleep monitoring. The method includes: monitoring physical sign information of a user in response to receiving a monitoring command; determining sleep quality information of the user according to the physical sign information of the user, wherein the physical sign information comprises at least breathing information.

Abstract: Provided herein are systems and methods for monitoring one or more health or physiological parameters in a subject. The systems and methods may comprise a patch coupled to an injector. Data may be transmitted to a mobile device or remote server, where the data may be processed. Processed data may be used to inform a subject on a health or physiological condition.

Abstract: A system and method for identifying and treating a disease in a patient collects one or more data streams from sensors configured to detect biological signals generated within a patient's tissue over time. Patient data elements including one or more of demographic, clinical, laboratory, pathology, chemical, image, historical, genetic, and activity data for the patient is collected and processed with the data streams to generate a personalized digital phenotype (PDP). The PDP is compared to a digital taxonomy comprising prior data to classify the patient into one or more quantitative disease classifications to guide personalized intervention for treating the patient.

Abstract: Safe and effective exercise poses a specific set of challenges for subjects diagnosed with diabetes. These challenges include the coordination of exercise with blood glucose monitoring and insulin administration. Failure to coordinate these factors effectively can lead to various pathologies related to aberrant blood glucose levels. Presented herein are methods, systems, algorithms, computer program products, and computer-executable code for exercise guidance and instruction specific to diabetes relief and management. The approaches as disclosed herein can help ameliorate, slow, or reduce a likelihood of developing a diabetic condition.

Abstract: Provided herein are methods of estimating subject-specific parameters of growth dynamics of a cancer tumor in a subject having cancer. The methods can be used to personalize treatment protocols for a subject, stage the given disease in the subject, measure response to therapy, phenotype for patient selection to participate in drug trials, measure stability of an anatomical structure, or predict rate of change of the given disease. Also provided are methods of predicting growth dynamics of a cancer tumor, and computer systems and computer-implemented methods for estimating subject-specific parameters of growth dynamics of a cancer tumor in a subject having cancer.

Abstract: An oral appliance for treating sleep apnea in a user includes a mouthpiece configured for being positioned in an oral cavity of the user, and at least one pulse oximeter attached to the mouthpiece. According to an aspect, the pulse oximeter is configured to monitor actual oxygen saturation levels of hemoglobin of the user when the oral appliance is positioned in the oral cavity of the user. The oral appliance may include an additional sensor attached to the mouthpiece that includes at least one of an airflow sensor, a pressure sensor, a noise detector, and an actigraphy sensor.