Patents Issued in January 4, 2024
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Publication number: 20240002301Abstract: A porous refractory in the K2O—SiO2—B2O3 system is formed by chemical direct foaming by heating to over 600° C., resulting in adherent black or white foam. The foam can function as highly porous thermal insulation, a high or low thermal emissivity surface, as a sealant for deteriorated refractory surfaces, as a filler for pockmarks/holes/gaps or as a bonding agent for parts with large gaps between them.Type: ApplicationFiled: September 18, 2023Publication date: January 4, 2024Applicant: ZYP Coatings, Inc.Inventors: Cressie E. Holcombe, JR., Patrick J. Ritt, William Brent Webb
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Publication number: 20240002302Abstract: A porous refractory in the K2O—SiO2—B2O3 system is formed by chemical direct foaming by heating to over 600° C., resulting in adherent black or white foam. The foam can function as highly porous thermal insulation, a high or low thermal emissivity surface, as a sealant for deteriorated refractory surfaces, as a filler for pockmarks/holes/gaps or as a bonding agent for parts with large gaps between them.Type: ApplicationFiled: September 18, 2023Publication date: January 4, 2024Applicant: ZYP Coatings, Inc.Inventors: Cressie E. Holcombe, JR., Patrick J. Ritt, William Brent Webb
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Publication number: 20240002303Abstract: A method for producing ceramic tiles, comprising the steps of providing a ceramic mixture, forming a raw tile with a body having an upper surface based on said mixture, and firing said raw tile to produce said ceramic tile, wherein the method comprises a step of producing a relief structure on said upper surface and wherein said structure is produced after said forming step and before said firing step.Type: ApplicationFiled: November 26, 2021Publication date: January 4, 2024Inventors: Lorenzo VALERIANI, Lorenzo CORRADINI
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Publication number: 20240002304Abstract: A method for manufacturing a decorative element comprising a substrate and a top layer wherein the substrate is made of an engineered stone and wherein the top layer comprises a decorative pattern, comprising the steps of: providing a mixture comprising at least an inorganic filler and a binder; compacting the mixture; and curing the binder to obtain the substrate; wherein the method comprises the step of inkjet printing a first decorative pattern on at least a top surface of the substrate, and wherein the method comprises the step of providing a protective coating above the printed pattern, wherein the protective coating comprises a base coat that is applied immediately on top of the printed pattern and a top-coat that is provided above the base coat, between the application of the base-coat and the application of the top coat the method comprises the step of sanding the base coat.Type: ApplicationFiled: November 8, 2022Publication date: January 4, 2024Inventors: Rahul PATKI, Eladio PINERO GONZALEZ, Claudio CASELLI
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Publication number: 20240002305Abstract: A fertilizer or plant growth promoter formed from a seed grind which can further include a source of sugar, a source of bicarbonate and a source of fertilizer nutrients, and a method of growing plants using the fertilizer or the plant growth promoter.Type: ApplicationFiled: September 11, 2023Publication date: January 4, 2024Inventors: Arthur R. Shirley, Jr., Melissa C. Hayes
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Publication number: 20240002306Abstract: The present disclosure, in various embodiments, discloses hydrothermal methods, hydrothermally modified materials and dried hydrothermally modified materials. Certain dried hydrothermally modified materials can readily releases ionic species such as alkali metal ions (K+, Na+), silicate salts, and alkaline earth metal ions (Mg2+, Ca2+). Some dried hydrothermally modified materials can readily release aluminum ions and/or silicon, such as in the form of soluble silicates. Such processes and materials are useful, for example in economically preparing potassium releasing fertilizers.Type: ApplicationFiled: May 17, 2023Publication date: January 4, 2024Inventors: Davide Ciceri, Marcelo de Oliveira, Antoine Allanore, Dennis P. Chen, Thomas C. Close
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Publication number: 20240002307Abstract: A strain of ciliated protozoan is provided, which has an obvious promoting effect on germination and growth of plant seeds. The ciliated protozoan is Colpoda sp. JH2-5-4, with preservation number of CCTCC NO.C202229. After collecting over 2,000 Colpoda strains from soils across China, the present invention has screened and selected a highly efficient and active strain suitable for use as a microbial fertilizer in plant cultivation. The selected ciliated protozoan can significantly shorten the germination time of plant seeds and improve seedling survival rate.Type: ApplicationFiled: June 7, 2023Publication date: January 4, 2024Applicant: OCEAN UNIVERSITY OF CHINAInventors: Hongan LONG, Yurou JIANG, Haichao LI, Jiao PAN
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Publication number: 20240002308Abstract: The present invention discloses a soil-structure improving bio-organic fertilizer and a preparation method thereof, and belongs to the technical field of biological fertilizers. The preparation method of the bio-organic fertilizer of the present invention includes the following steps: S1: aerobically fermenting cow dung-based organic materials to prepare a solid-state fermentation medium; S2: inoculating Bacillus subtilis fermentation broth and silicate bacteria fermentation broth into the solid-state fermentation medium for solid-state fermentation until the end of fermentation; and S3: after the fermentation is finished, extruding and granulating or directly sieving to prepare the soil-structure improving bio-organic fertilizer.Type: ApplicationFiled: September 14, 2023Publication date: January 4, 2024Inventors: Lihua Jiang, Chunxiu Wei, Yan Yang, Baozhong Zhao, Xueping Li, Lesen Zhang, Yu Xu, Jing Shi, Mei Wang, Yumin Liu
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Publication number: 20240002309Abstract: The invention relates to a process for producing a controlled release fertilizer of potassium chloride comprising the following steps: a. providing compacted KCl, having a sphericity of below 0.87; b. dry polishing the KCl in an intensive mixer type device consisting of a container vessel and at least one set of agitating elements such that the KCl has a sphericity of between 0.88 and 0.92; c. providing a coating on said polished KCl. The polished and coated compacted KCl can show with 6 pph coating a release of about 18% after 7 days measured with a water leach test at 21 C. The polished and coated compacted KCl may have one or more of the following release properties: a release at 10 days of about 20% or less; and/or a release at 30 days of 40% or less; and/or a release at 50 days of 50% or less.Type: ApplicationFiled: November 26, 2021Publication date: January 4, 2024Applicant: EVERRIS INTERNATIONAL B.V.Inventors: Ronnie Andreas Marie JENNISSEN, Pascalle Joseph Maria PELGROM, Jésus HERNÁNDEZ MARTÍNEZ
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Publication number: 20240002310Abstract: An energetic composition and a method of unzipping polymer binders are disclosed, which includes localizing a heat feedback just near the reaction front by unzipping polymer binders employed to a nanothermite. The energetic composition includes an unzipping polymer binder employed to high load fuel and oxidizer particles.Type: ApplicationFiled: June 28, 2023Publication date: January 4, 2024Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, The Board of Trustees of the University of IllinoisInventors: Haiyang Wang, Michael R. Zachariah, Jeffrey S. Moore, Mayank Garg
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Publication number: 20240002311Abstract: Provided is a gas-generating agent composition containing the components (a) to (d) below, in which an average particle size of the following component (d) basic magnesium carbonate is 12 ?m or less: (a) guanidine nitrate; (b) a basic metal nitrate; (c) a binder; and (d) basic magnesium carbonate.Type: ApplicationFiled: September 30, 2021Publication date: January 4, 2024Applicant: DAICEL CORPORATIONInventors: Youji FUJISAKI, Ayumi FUJINO, Shunji NAKAI
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Publication number: 20240002312Abstract: Provided is a method for preparing a deuterated anthracene compound, the method including synthesizing a deuterated anthracene compound by reacting a halogenated benzene having at least one deuterium with a compound of Chemical Formula 1: wherein Ar1 is deuterium, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group; and Ar2 is hydrogen, deuterium, a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group. Also provided are a reaction composition, a deuterated anthracene compound, and a composition containing the deuterated anthracene compound.Type: ApplicationFiled: January 21, 2022Publication date: January 4, 2024Inventors: Sunmin KIM, Kyung Seok JEONG, Woo Han KIM, Changyoung JUNG
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Publication number: 20240002313Abstract: [Object] Provided are a 11C-labeled acyclic retinoid that can be synthesized in a short time with a high yield and can be suitably used for PET for elucidating intracerebral kinetics, a PET probe using it, and methods for producing them. [Solution] The 11C-labeled acyclic retinoid of the present invention is characterized by being represented by the following chemical formula (a). This compound can be produced by a coupling step of cross-coupling a methyl iodide labelled with 11C and the following organotin compound (b) (provided that in the formula, R1 and R2 represent alkyl groups which may have a branch) in an aprotic solvent in the presence of a palladium complex, a phosphine ligand, and a cuprous halide.Type: ApplicationFiled: November 18, 2021Publication date: January 4, 2024Applicant: NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGYInventors: Masaaki SUZUKI, Kengo ITO, Yasuyuki KIMURA, Aya OGATA, Hiroshi IKENUMA, Tetsuya KIMURA, Nobuyuki KIMURA, Hiroko KOYAMA, Hideki ISHII, Meiei CHO, Kazunori KAWAMURA, Takafumi MINAMIMOTO, Yuji NAGAI, Hiroshi KATSUKI
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Publication number: 20240002314Abstract: The hydrocarbon production method includes a first production step of producing carbon monoxide using carbon dioxide contained in source gas, and a second production step of producing hydrocarbon using hydrogen contained in source gas and carbon monoxide. The source gas contains at least one of carbon dioxide, carbon monoxide, and hydrogen not derived from fossil fuel.Type: ApplicationFiled: December 24, 2021Publication date: January 4, 2024Applicant: ENEOS CorporationInventors: Atsushi KOBAYASHI, Akira GOTO, Takuya KAJITA
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Publication number: 20240002315Abstract: The present disclosure relates generally to processes for the production of methane from hydrogen and carbon dioxide. In particular, the disclosure provides for a process for providing a product composition comprising methane. The process includes contacting a gaseous mixture comprising hydrogen and carbon dioxide with a supported methane synthesis catalyst, the supported methane synthesis catalyst comprising cobalt in the range of 1 wt % to 35 wt % on an elemental basis, to provide the product composition with a methane selectivity of at least 75%.Type: ApplicationFiled: December 21, 2021Publication date: January 4, 2024Inventor: Alexander James Paterson
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Publication number: 20240002316Abstract: The invention provides a process for producing alpha-olefins comprising: a) contacting an ethylene feed with an oligomerization catalyst system, the catalyst system comprising a metal-ligand catalyst and a co-catalyst, in an oligomerization reaction zone under oligomerization conditions to produce a product stream comprising alpha-olefins; b) withdrawing the product stream from the oligomerization reaction zone wherein the product stream further comprises oligomerization catalyst system; c) contacting the product stream with a catalyst deactivating agent to form a deactivated product stream that contains deactivated catalyst components; and d) heating the deactivated product stream to separate one or more components from the deactivated product stream.Type: ApplicationFiled: December 14, 2021Publication date: January 4, 2024Inventors: Valerie Anne WILLIAMS, Cornelius Mark BOLINGER, Brent Carl NORRIS
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Publication number: 20240002317Abstract: The present disclosure relates generally to compositions and processes for producing Fischer-Tropsch catalysts. In particular, the disclosure provides for a process for producing a product composition comprising alcohols and liquid hydrocarbons via a Fischer-Tropsch synthesis reaction, the process comprising: contacting a mixture of hydrogen and a gaseous carbon oxide that is carbon monoxide, carbon dioxide or a combination thereof and an olefin co-feed with a supported cobalt-manganese Fischer-Tropsch synthesis catalyst to provide the product composition; wherein the olefin co-feed comprises at least one C2-C14 olefin and is present in an amount in the range of 0.001 wt % to 40 wt % relative to the total amount of hydrogen, the gaseous carbon oxide and olefin; wherein a weight ratio of manganese to cobalt in the catalyst is at least 0.05 on an elemental basis.Type: ApplicationFiled: December 17, 2021Publication date: January 4, 2024Inventors: Alexander James Paterson, John Glenn Sunley
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Publication number: 20240002318Abstract: The invention relates to a method for producing methanol by the CO2 conversion route in a photocatalytic process, wherein a base liquid (A) in the form of demineralized and CO2-saturated water is provided to the reaction tank (1) and graphene material (B) is provided and the contents of the reaction tank (1) is exposed to electromagnetic radiation with a wavelength in the UV-VIS-FIR range that is generated by an emitter (D). The invention also relates to an installation for implementing the method.Type: ApplicationFiled: November 29, 2021Publication date: January 4, 2024Inventors: Yuriy GERASYMCHUK, Pawel GLUCHOWSKI, Wlodzimierz MISTA, Wieslaw STREK, Przemyslaw WIEWIORSKI, Robert TOMALA
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Publication number: 20240002319Abstract: A process for preparing metal alkoxides by transalcoholisation, comprising: feeding a lower metal alkoxide and a higher alcohol into a reactive distillation column; removing a solution of a higher metal alkoxide in the higher alcohol from the bottom of the column or from a recycle stream taken from the bottom of the column; and removing a gaseous lower alcohol from the top of the column, at least partially condensing the gaseous lower alcohol, and recirculating a part of the condensate to the top of the column; wherein an auxiliary alcohol is provided in the reactive distillation column, the boiling point of the auxiliary alcohol being between the boiling point of the lower alcohol and the boiling point of the higher alcohol at the pressure prevailing in the reactive distillation column. The process allows for high conversion of a lower metal alkoxide to a higher metal alkoxide while limiting the formation of solid deposits in the column, while having low energy requirements.Type: ApplicationFiled: December 1, 2021Publication date: January 4, 2024Inventors: Wolf-Steffen WEISSKER, Edward RICHMOND
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Publication number: 20240002320Abstract: Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides high purity CBG, CBGA, and analogs thereof.Type: ApplicationFiled: September 15, 2023Publication date: January 4, 2024Applicant: Canopy Growth CorporationInventors: Daniel BRUMAR, Mahmood Azizpour FARD, Ben GEILING, Mohammadmehdi HAGHDOOST MANJILI
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Publication number: 20240002321Abstract: Systems and methods for producing an alkyl tert-butyl ether are disclosed. The methods include providing heat to a reboiler of a distillation column of an alkyl tert-butyl ether production unit from a flue gas emanating from a unit carrying out a catalyst regeneration process.Type: ApplicationFiled: November 23, 2021Publication date: January 4, 2024Applicant: SABIC GLOBAL TECHNOLOGIES B.V.Inventors: Mohammed Bismillah ANSARI, Vijay Dinkar BODAS, Muhammad Imran YAQUB
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Publication number: 20240002322Abstract: The present invention relates to a novel method for producing an intermediate expressed by chemical formula 5 that can be effectively used in synthesis of sphingosine-1-phosphate receptor agonist.Type: ApplicationFiled: October 12, 2021Publication date: January 4, 2024Applicant: LG CHEM, LTD.Inventors: Sung Wook KIM, Ki Dae KIM, Soo Min LEE, Ho Yeon LEE, Jin Ok HAM
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Publication number: 20240002323Abstract: A process for the preparation of cis-2-alkenoic acid or an alkali metal salt thereof, comprising rearranging 1,3-dibromo-2-alkanone in an alkaline environment in the presence of a catalytically effective amount of an alkali metal salt of cis-2-alkenoic acid, and isolating from the reaction mixture cis-2-alkenoic acid, either in the form of the free acid or in the form of the alkali metal salt.Type: ApplicationFiled: November 30, 2021Publication date: January 4, 2024Inventors: Jakob OREN, Nasif YASSIN, Nicka CHINKOV, Ronit YAHALOMI SEGUI
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Publication number: 20240002324Abstract: Provided is a one-pot process for preparing propionic acid, which comprises (i) treating ethylene with a C1-C6 alkanol, water, and carbon monoxide in the presence of a catalyst system comprising the reaction product of (a) a Group 8 to 10 transition metal compound such as a palladium or ruthenium compound; and (b) an activating anion, at elevated temperature and pressure. The process also provides a facile, continuous process for the preparation of propionic acid via the alkoxycarbonylation of ethylene at elevated temperature and pressure followed by hydrolysis, in one reaction vessel.Type: ApplicationFiled: July 21, 2021Publication date: January 4, 2024Applicant: EASTMAN CHEMICAL COMPANYInventors: DAMON RAY BILLODEAUX, KENNETH WAYNE HAMPTON, Jr., CAREY DAN ASHCROFT
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Publication number: 20240002325Abstract: The present disclosure relates to oxylipins, processes for making the same, and methods of using. The process may form deuterated oxylipins that can be used as mass standards for mass spectroscopy.Type: ApplicationFiled: October 26, 2021Publication date: January 4, 2024Inventors: Mithun SINHA, Robert MINTO, Imran Khan MOHAMMED
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Publication number: 20240002326Abstract: Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.Type: ApplicationFiled: June 27, 2023Publication date: January 4, 2024Inventors: Mathias FRANCOIS, Johannes ZUEGG, Jeroen OVERMAN, Sreeman Kumar MAMIDYALA, Angela Aguslyarti SALIM, Frank Roger FONTAINE, Matthew Allister COOPER, Robert John CAPON, Avril Alexis Barbara ROBERTSON
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Publication number: 20240002327Abstract: Provided are a method for preparing modified natural oil using an organocatalyst supported on a polymer and a modified natural oil prepared using the same. According to the present invention, there are effects of increasing the content of monomers as a main product of modified natural oil, minimizing side products, and easily recovering and repeatedly reusing organocatalysts supported on a polymer.Type: ApplicationFiled: June 5, 2023Publication date: January 4, 2024Inventors: Sae-Hume Park, Ji-Hoon Shin
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Publication number: 20240002328Abstract: The present invention relates to a catalyst system for preparing a carbonate derivative, comprising selenium (Se) and a pyridine amine compound represented by structural formula 1. The catalyst system for preparing a carbonate derivative, and a method for preparing a carbonate derivative by using same, of the present invention, allow an alcohol to undergo oxidative carbonylation by using a selenium-based catalyst system, and thus are more economical than a conventional carbonylation process and can obtain a dialkyl carbonate in feasible yields.Type: ApplicationFiled: July 8, 2021Publication date: January 4, 2024Inventors: Yong Jin KIM, Jayeon BAEK, Hye Jin LEE
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Publication number: 20240002329Abstract: The present invention relates to a method of preparing a heterogeneous linear carbonate, the method including performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst, wherein the catalyst is one or more selected from the group consisting of lithium methoxide (LME), lithium ethoxide (LEE), sodium methoxide (SME), sodium hydroxide (NaOH), and a mixture thereof, and the catalyst is input in a state of being dissolved in a sulfoxide-based solvent.Type: ApplicationFiled: November 5, 2021Publication date: January 4, 2024Applicant: LOTTE CHEMICAL CORPORATIONInventors: Wang Gyu Kim, Mi Hwa Baek, Jong Myung Choi, Eun Hye Han, Jin Hyung Kim
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Publication number: 20240002330Abstract: Provided herein is a method of preparing a heterogeneous linear carbonate, including: performing a transesterification reaction of dimethyl carbonate (DMC) and ethanol (EtOH) in the presence of a catalyst; and filtering a composite obtained by the transesterification reaction through a filter.Type: ApplicationFiled: November 4, 2021Publication date: January 4, 2024Applicant: LOTTE CHEMICAL CORPORATIONInventors: Wang Gyu Kim, Mi Hwa Baek, Jong Myung Choi, Eun Hye Han, Jin Hyung Kim
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Publication number: 20240002331Abstract: Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.Type: ApplicationFiled: June 7, 2023Publication date: January 4, 2024Inventors: Mir ALI, Austin Wayne BOESCH, Daryl Clark DRUMMOND, William KUHLMAN, Ulrik NIELSEN
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Publication number: 20240002332Abstract: The present disclosure relates generally to compounds, pharmaceutical compositions comprising them, and methods of using the compounds and compositions for treating disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), commonly referred to as coronavirus disease 2019 (COVID-19). The present disclosure relates more particularly to small molecule inhibitors of SARS-CoV-2 of Formula (II) and prodrug derivatives thereof of Formula (I), and methods of treating COVID-19 therewith.Type: ApplicationFiled: November 18, 2021Publication date: January 4, 2024Inventors: Wenwei Huang, Khalida Shamim, Hengli Tang
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Publication number: 20240002333Abstract: The present disclosure provides linear and cyclic oligoamides. The present disclosure also provides methods of making and uses of linear and cyclic oligoamides. The linear and/or cyclic oliogoamides may be used in methods such as, for example, forming transmembrane pores for transmembrane transport of hydrogen-bond acceptors and/or ions, sequestering hydrogen-bond acceptors and/or ions (e.g., anions), or the like. Compounds of the present disclosure may be used to enrich materials with ions (e.g., lithium).Type: ApplicationFiled: September 13, 2021Publication date: January 4, 2024Inventor: Bing Gong
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Publication number: 20240002334Abstract: Described herein are ralinepag prodrugs, as well as pharmaceutical compositions thereof, and methods of use thereof in the treatment of diseases or conditions that would benefit from treatment with a prostacyclin (IP) receptor agonist compound, such as but not limited to pulmonary hypertension (PH) diseases.Type: ApplicationFiled: March 17, 2023Publication date: January 4, 2024Inventors: Hitesh BATRA, Patrick POISSON, Liang GUO, Susovan JANA, Sri Harsha TUMMALA
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Publication number: 20240002335Abstract: A process of prilling of a urea melt comprising the use of calcium lignosulfonate or carboxymethyl starch as additive to obtain a formaldehyde-free urea product.Type: ApplicationFiled: September 10, 2021Publication date: January 4, 2024Applicant: Casale SAInventors: Leonardo Marrone, Andrea Beretti
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Publication number: 20240002336Abstract: A polythiol composition according to exemplary embodiments includes a main polythiol compound and a sub-compound having a molecular weight higher than that of the main polythiol compound. A peak area (%) at retention times ranging from 34 to 40 minutes in the high performance liquid chromatography (HPLC) analysis graph obtained at a wavelength of 230 nm, which corresponds to the sub-compound, is 2.5% or less. An optical product having improved transmittance and optical properties may be manufactured through fine adjustment of the sub-compound.Type: ApplicationFiled: November 23, 2021Publication date: January 4, 2024Inventors: Jae Young PAI, Jeong Moo KIM, Hyuk Hee HAN, Jung Hwan MYUNG, Kyeong Hwan YOU, Joo Young JUNG, Ji Yeon RYU, Myung Ok KYUN
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Publication number: 20240002337Abstract: The present disclosure is directed to salt and solid forms of (R)-1-(5-METHOXY-1H-INDOL-1-YL)-N,N-DIMETHYLPROPAN-2-AMINE and methods of treating neurological disorder and/or a psychiatric disorder in a subject in need thereof.Type: ApplicationFiled: November 16, 2022Publication date: January 4, 2024Inventors: Matthew DUNCTON, Samuel CLARK
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Publication number: 20240002338Abstract: The present disclosure provides a composition comprising crystalline forms A, B, and C of psilocin and psilocybin. Solvent screen, X-ray powder diffractogram, thermogravimetric mass spectroscopy, differential scanning calorimetry, 1H-NMR, dynamic vapor sorption, and UPLC data on each of the crystalline forms is presented, along with methods preparing each of the crystalline forms.Type: ApplicationFiled: June 1, 2023Publication date: January 4, 2024Inventor: Peter Silverstone
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Publication number: 20240002339Abstract: The invention provides a compound of Formula (I): or a salt thereof, wherein R1-R3, R5-R11, Z, X, and L have any of the values described in the specification, as well as compositions comprising a compound of Formula (I). The compounds are useful as cyclin-dependent kinase 2 (CDK2) inhibitors.Type: ApplicationFiled: June 29, 2023Publication date: January 4, 2024Inventors: Ingrid Gunda Georg, Timothy Ward, Erik Faber, Jon E. Hawkinson, Nan Wang, Ernst Schonbrunn
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Publication number: 20240002340Abstract: A method for producing a compound represented by the formula (1): wherein LG is a leaving group, PG1 is an amino-protecting group, and R is a hydrocarbon group having 1-8 carbon atoms and optionally having substituent(s), comprising reacting a compound represented by the formula (6): with an amino group protecting agent to obtain a compound represented by the formula (7): or a salt thereof; reacting the aforementioned compound represented by the formula (7) with a lactonization agent to obtain a compound represented by the formula (8): reacting the aforementioned compound represented by the formula (8) with an esterification agent to obtain a compound represented by the formula (9): and reacting the aforementioned compound represented by the formula (9) with a leaving group introduction agent.Type: ApplicationFiled: September 7, 2023Publication date: January 4, 2024Applicant: API CORPORATIONInventors: Masato MURAI, Jun TAKEHARA, Daiki OKADO
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Publication number: 20240002341Abstract: This disclosure relates to processes for preparing nicotinic acid derivatives that are useful in the chemical arts, such as in the manufacture of pharmaceutical products or agrochemicals. In particular, the present disclosure pertains to novel processes for preparing certain nicotinic acid derivatives.Type: ApplicationFiled: October 22, 2021Publication date: January 4, 2024Inventors: Ramiah MURUGAN, Colin SMITH, Roger W. THARP-TAYLOR
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Publication number: 20240002342Abstract: Compounds of the Formula (I) wherein the substituents are as defined in claim 1. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.Type: ApplicationFiled: November 26, 2021Publication date: January 4, 2024Applicant: SYNGENTA CROP PROTECTION AGInventors: Suzanna Jane DALE, Christopher James MARTIN, David BURNS
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Publication number: 20240002343Abstract: The present invention provides a compound for treating or preventing diseases caused by mitochondrial hyperfission. The present invention provides a compound represented by formula (1): wherein R1 and R1? are each independently hydrogen, an optionally substituted lower alkyl, an optionally substituted lower cycloalkyl, and the like; R2 is an optionally substituted lower alkyl, an optionally substituted lower cycloalkyl, and the like; R3 and R4 are each independently hydrogen, halogen, hydroxy, nitro, cyano, an optionally substituted lower alkyl, and the like; R5 and R6 are each independently an optionally substituted lower alkyl; an optionally substituted lower cycloalkyl, and the like; X is nitrogen or oxygen; Y is carbon, nitrogen or oxygen; and a broken line represents the presence or absence of a bond; or a pharmaceutically acceptable salt, a solvate, or a prodrug thereof.Type: ApplicationFiled: November 29, 2021Publication date: January 4, 2024Applicant: KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATIONInventors: Eiji KAWANISHI, Akio OJIDA, Motohiro NISHIDA, Yuri KATO
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Publication number: 20240002344Abstract: The present disclosure relates generally to compounds and pharmaceutical compositions for the selective inhibition of histone lysine demethylase5 (KDM5), particularly KDM5B, and methods of their use in treating conditions and diseases associated with KDM5 activity.Type: ApplicationFiled: August 27, 2021Publication date: January 4, 2024Inventors: Zuhui ZHANG, Xiaoti Zhou, Michael P. Arend, Christian Hauge Kjaergaard
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Publication number: 20240002345Abstract: The present specification relates to a heterocyclic compound represented by Formula 1, an organic light-emitting device comprising the same, a manufacturing method thereof, and a composition for an organic layer thereof.Type: ApplicationFiled: November 9, 2021Publication date: January 4, 2024Applicant: LT MATERIALS CO., LTD.Inventors: Su Jin KWON, Sol LEE, Jun Tae MO, Dong Jun KIM
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Publication number: 20240002346Abstract: The present disclosure provides compounds that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.Type: ApplicationFiled: March 2, 2023Publication date: January 4, 2024Inventors: Qi WEI, Heping SHI, Matt TSCHANTZ, Jian QIU, Youtong WU, Huiling TAN, Lijun SUN, Chuo CHEN, Zhijian CHEN
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Publication number: 20240002347Abstract: Compounds capable of, or usable in, inducing death of cancer cells and/or modulating a biological activity of a chemokine e.g., cell migration, and/or treating diseases and disorders associated with a biological activity of a chemokine and/or cell migration, and/or in treating cancer, are provided herein. The compounds are collectively represented by Formulae Ia or Ib: wherein A, B, D, E, G and R1-R5 are as defined in the specification, with one or more of D, E and G, preferably E, is hydroxy.Type: ApplicationFiled: September 19, 2023Publication date: January 4, 2024Applicant: AlonBio Ltd.Inventors: Amnon PELED, Michal ABRAHAM KARNI, Orly EIZENBERG
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Publication number: 20240002348Abstract: The present invention relates to quinolones of formula (I) and process for its preparation by amine insertion into aryl-ynones thereof. [Formula I] The invention further relates to the process to obtain the natural products such as: graveoline, graveolinine, pseudane IV, pseudane VII, pseudane VIII and pseudane XII. The invention also describes the process for the total synthesis of waltherione F in concise approach from the quinolone synthesized.Type: ApplicationFiled: August 17, 2021Publication date: January 4, 2024Inventors: Srihari PABBARAJA, Goverdhan MEHTA, Shweta SINGH
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Publication number: 20240002349Abstract: Provided herein are optionally substituted benzoimidazol-1,2-yl amides, pharmaceutical compositions comprising a therapeutically effective amount of such compounds and a pharmaceutically acceptable excipient, and methods of treating Kv7 associated diseases, such as, epilepsy, amyotrophic lateral sclerosis, various types of pain, hyperexcitability, a dyskinesia, dystonia, mania and tinnitus with such compounds and pharmaceutical compositions.Type: ApplicationFiled: June 20, 2023Publication date: January 4, 2024Inventors: Michael E. BOZIK, Scott S. HARRIED, Lynn RESNICK, George T. TOPALOV, Justin K. BELARDI, Charles A. FLENTGE, David A. MARESKA, James S. HALE
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Publication number: 20240002350Abstract: Disclosed are compounds and methods for preventing or treating necroinflammation associated with ferroptotic processes. The method includes inhibiting 15 lipoxygenase/phosphatidylethanolamine binding protein (15LOX/PEBP1) complex, wherein the inhibitor exhibits a higher binding affinity or binding activity for 15LOX/PEBP1 complex compared to 15LOX alone. Necroinflammation associated with ferroptotic processes causes several pathogenic conditions including upper or lower respiratory disorders, acute or chronic brain injury, renal injury, injury by radiation, neurodegenerative disorder, among others. The disclosed compounds and methods are useful in subjects diagnosed with one or more of these conditions.Type: ApplicationFiled: November 17, 2021Publication date: January 4, 2024Inventors: Sally Ellen MORGANROTH, Valerian KAGAN, Jinming ZHAO, Ganesha RAI, Hulya BAYIR, Yulia TYURINA, Haider DAR, Tamil ANTHONYMUTHU, Joel GREENBERGER, Michael EPPERLY, Diane LUCI, Juan MARUGAN, Anton SIMEONOV, Alexey V. ZAKHAROV, Adam YASGAR, Andrew AMOSCATO