Abstract: A nervous tissue imaging system and a method therefor. The system includes: a housing containing an excitation light source, optically coupled with a source optical train, the excitation light source emits excitation light in a first wavelength range, which can be in a near ultraviolet light range, to illuminate a tissue region of interest including healthy nervous tissue and healthy non-nervous tissue. The excitation light in the first wavelength range causes the healthy nervous tissue, in response to being illuminated with the excitation light, to endogenously autoflouresce and emit first autofluorescence light at a first luminance in a second wavelength range. The healthy non-nervous tissue, in response to being illuminated with the excitation light, either avoids emitting any autofluorescence light in the second wavelength range; or endogenously autoflouresces and emits second autofluorescence light in the second wavelength range at a second luminance that is lower than the first luminance.

Abstract: An imaging system is provided comprising an imaging probe and at least one delivery device. The imaging probe comprises an elongate shaft, a rotatable optical core and an optical assembly. The elongate shaft comprises a proximal end, a distal portion, and a lumen extending between the proximal end and the distal portion. The rotatable optical core is positioned within the lumen of the elongate shaft and comprises a proximal end and a distal end. The rotatable optical core is configured to optically and mechanically connect with an interface unit. The optical assembly is positioned in the elongate shaft distal portion and proximate the rotatable optical core distal end. The optical assembly is configured to direct light to tissue and collect reflected light from the tissue. The imaging probe is constructed and arranged to collect image data from a patient site. The at least one delivery device is constructed and arranged to slidingly engage the imaging probe.

Abstract: An endoscope device includes a processor configured to calculate light source control information based on first information regarding a scope and second information regarding a light source device, and to control a light source of the light source device based on the light source control information. The second information includes a ratio of an amount of light emitted from a distal end of a reference scope to an amount of light emitted from the light source device to the reference scope.

Abstract: A medical device processor includes a chemical dosing system including a supply tube extending along a length between a first and second end. A pump is coupled to the supply tube downstream from the first end and configured to pump fluid in the tube. A bubble detector is coupled to the supply tube downstream from the first end, wherein an inner volume of the supply tube between the bubble detector and the second end is equal to or greater than a volume of a dose of liquid to be pumped from the chemical dosing system in a given dose. A controller is configured to run the pump for a predetermined period of time; detect the presence of one or more bubbles in the supply line based on measurement by the bubble detector; upon detection, continue to run the pump for the remainder of the predetermined time; and issue a notification.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container extending from a first end to a second end and having a reduced diameter stem extending from the first end, the reduced diameter stem defining an opening for receiving a fluid, a water outlet, a gas inlet, and a port. The port may comprise a sealing ring defining an aperture extending from a first end to a second of the sealing ring, the aperture in fluid communication with the opening in the container, a cap positioned adjacent to the first end of the aperture of the sealing ring, and a biasing mechanism disposed between the container and the sealing ring.

Abstract: An intraoral scanner according to an embodiment of the present disclosure includes: a camera module comprising at least one camera; a communication unit including a first communication module configured to perform wireless communication in a first frequency band, and a second communication module configured to perform wireless communication in a second frequency band; and a processor configured to execute at least one instruction.

Abstract: A photography support device is configured to support photography of N types (where N is an integer greater than 1) of photography target parts defined in advance. The photography support device includes at least one memory and at least one processor which function as: a determining unit configured to determine, with respect to a plurality of images obtained by photography of inside of an oral cavity of a patient, which of the N types of photography target parts a photography target part in each image corresponds to; and a missing-image sensing unit configured to, based on determination results regarding each of the plurality of images, sense whether or not shooting of images of the N types of photography target parts is complete.

Abstract: A method for performing a full-field stimulus threshold (FST) test on a test subject, the method comprising: delivering at least one visual stimulus to at least one eye of the test subject, wherein the least one visual stimulus comprises a flash of light having an intensity and a duration, wherein the intensity of the flash of light is adjusted over the duration of the flash of light; obtaining at least one response from the test subject, wherein the at least one response corresponds to whether the test subject perceived the at least one visual stimulus; and determining the lowest intensity of light that the test subject is able to perceive based on the at least one response from the test subject.

Abstract: A method for administering a cone contrast color vision test includes displaying a first color at a first contrast level in a first region of a display and a second color at a first contrast level in a second region of the display, receiving a first input signal via an input device that indicates whether the patient recognizes the first region, displaying the first color at a second contrast level in a third region of the display and the second color at a second contrast level in a fourth region of the display, receiving a second input signal indicative of whether the patient recognizes the third region, assigning a score related to cone sensitivity of the first color at the first and second contrast levels, storing the score, and comparing the score to a previous score to calculate a progression of a cone sensitivity loss.

Abstract: An ophthalmic information processing apparatus includes an acquisition unit and a normalizer. The acquisition unit is configured to acquire eye shape data or an intraocular distance of an eye of a subject. The normalizer is configured to normalize the eye shape data or the intraocular distance based on body data of the subject or a refractive power of the eye of the subject.

Abstract: Using the present solution, it is possible both to determine optical aberrations and/or the topography and to simultaneously or immediately successively record reference images of an eye. Within the scope of the method, the eye is illuminated with different illumination patterns by means of an illumination unit, and the light reflected by the eye is recorded by a plenoptic camera sensor and evaluated by a control and evaluation unit. According to the invention, the eye is illuminated with different illumination patterns which differ in respect of their intensity distribution and illumination direction, the light reflected by the eye is imaged onto the plenoptic camera sensor and the topography and/or optical aberrations and/or reference images of the illuminated eye are determined from the image data of the plenoptic camera sensor on the basis of the utilized illumination pattern.

Abstract: Performing a corrective operation for environmental conditions related to a predetermined eye condition includes obtaining environment sensor data from a one or more sensors of the device, determining a current context for the device based on the environment sensor data, and determining, based on the current context, that an eye state criterion is satisfied. In response to determining that the eye state criterion is satisfied, a corrective operation is determined in accordance with the eye state criterion, and the corrective operation is performed. When performed, the corrective operation is configured to resolve an environmental condition associated with the eye state criterion.

Abstract: According to an exemplary embodiment of the present disclosure, a pressure sensing device using a sensor based on a Wheatstone bridge includes: a half Wheatstone bridge unit including two variable resistors of which resistance values are changed according to an environmental change; a variable capacitor unit electrically connected to the half Wheatstone bridge unit and generating RC delays for two variable resistors, respectively; an amplifier amplifying respective charging voltages charged after a time of the respective RC delays; and a comparator comparing the amplified charging voltages and outputting the compared charging voltages as digital values. As a result, an intraocular pressure sensing device is further miniaturized and has smaller power loss.

Abstract: A method of automating the collection, association, and coordination of multiple medical data sources using a coordinating service application, computer, database, and/or server system to manage devices, examinations, and people involved in the medical examination and treatment process. In an embodiment, the method comprises authenticating a user for a premises, a device, or a device group, validating particular use of the device based on user credentials or type of device or device group, associating a medical examination with a patient or a medical examination schedule, associating medical examination data from a device or device group with a related medical examination session, routing medical examination data to a computer, database, or server, and pairing medical examination session data with a medical interpretation, clinical testing results, diagnoses, and/or other recorded information.

Abstract: Embodiments herein relate to ear-wearable devices configured to detect aberrant patterns indicative of events related to the safety or health of a wearer and related methods. In a first aspect, an ear-wearable device is included having a control circuit, a microphone, a motion sensor, and a power supply. The ear-wearable device is configured to monitor signals from the microphone and/or the motion sensor to identify an aberrant pattern, and issue an alert when an aberrant pattern is detected. Other embodiments are also included herein.

Abstract: A system and method for depth-resolved imaging of fluorophore concentrations in tissue uses a pulsed light source stimulus wavelength to illuminate the tissue; and a time-gated electronic camera such as a single-photon avalanche detector camera to observe the tissue in multiple time windows after start of each light pulse. A filter device is between the tissue and the electronic camera with fluorescent imaging and stimulus wavelength settings. an image processor receives reflectance images and fluorescent emissions images from the time-gated camera and processes these images into depth and quantity resolved images of fluorophore concentrations in the tissue. Then image processor derives a fluorescence lifetime signal from the received temporal fluorescence signals and derives from these fluorescence lifetime signals biochemical property images of the tissue.

Abstract: A sensing system includes laser diodes with Bragg reflectors generating light having an initial light intensity and one or more near-infrared optical wavelengths. The laser diodes are modulated with a pulsed output with 0.5 to 2 nanosecond pulse duration. A beam splitter receives light from the laser diodes, splits the light into a received sample arm light directed to an object and a received reference arm light. A detection system includes a second lens and spectral filters in front of a photodiode array. The photodiode array is coupled to CMOS transistors and receives at least a portion of the received reference arm light and generates a reference detector signal. The detection system is synchronized with the laser diodes. A time-of-flight measurement is based on a comparison of the sample detector signal and the reference detector signal and measures a temporal distribution of photons in the received reflected sample arm light.

Abstract: A laser beam is applied to a photoacoustic wave generation source multiple times in a reception period of ultrasound waves during photoacoustic imaging. As a result, a plurality of photoacoustic waves are generated from the photoacoustic wave generation source in the reception period and received by a reception unit of an ultrasound imaging apparatus. The positions of the plurality of photoacoustic waves on a time axis is adjusted, and the plurality of photoacoustic waves are averaged. A photoacoustic image is generated based on a signal obtained through the averaging.

Abstract: A patient monitoring method comprises receiving (103, 109) input data indicative of shivering episodes (52) and sweating episodes (54) of a patient; recording (105, 111) the respective points in time at which the shivering episodes and sweating episodes occur; and generating (115, 117) an output based on an alternating pattern of the shivering episodes and sweating episodes from the recorded respective points in time of the respective shivering and/or episodes. Also disclosed is a computer program product for implementing such a method and a monitoring system (10) arranged to implement such a method.

Abstract: A medical instrument for use in telemedicine application including an elongated member connected to a central member. The central member includes a diaphragm at one end and a bell at another end, each used for different listening sounds of a living subject such as an animal or human body. The medical instrument amplifies audio signals up to forty-five times associated with a patient's heartbeat, breathing, blood flow, digestion, or any other biological process that produces audio signals. The medical instrument records electrical heart tracings (ECG tracings) and super-imposes the digital visual representation of the audio signals from heart simultaneously. The medical instrument transmits data remotely to a server and/or a user device for analysing the heart rate, rhythm (both regular and irregular) and changes that could suggest atrial fibrillation, tachyarrhythmia, dissociations, ischemia and ventricular contractions. The medical instrument acts as an ear free listening device and a heart rate monitor.

Abstract: A medical device (20) includes a case (26) of a size and shape suitable to be held in a hand (24) of a subject (22). An acoustic transducer (36) is disposed in the case and configured to output an acoustical signal in response to acoustic waves that are emitted from a thorax of the subject and received through the front surface of the case when the subject holds the case against the thorax. One or more sensors (46, 48, 50) are disposed on the case and configured to acquire one or more physiological signals from one or more fingers (30) of the subject while the subject holds the case in the hand. Processing circuitry (40) is contained in the case and coupled to receive and process the acoustical signal and the one or more physiological signals and to output data indicative of a medical condition of the subject.

Abstract: This invention discloses an electronic device for measuring physiological parameters of a living subject including at least a first inertial measurement unit (IMU) and a second IMU, the first IMU and the second IMU are time-synchronized to and spatially and mechanically separated from each other; and a microcontroller unit (MCU) electronically coupled to the first IMU and the second IMU for processing of data streams from the first IMU and the second IMU.

Abstract: The present disclosure relates to a real-time blood pressure monitoring system based on photoplethysmography (PPG) using convolutional?bidirectional long short-term memory (LSTM) recurrent neural networks and a real-time blood pressure monitoring method using the same. According to the present disclosure, there is provided the real-time blood pressure monitoring system based on PPG using convolutional?bidirectional LSTM recurrent neural networks, including a pulse wave measurement module configured to measure the PPG, and a blood pressure estimation server configured to receive the measured PPG from the pulse wave measurement module and estimate a blood pressure via the recurrent neural networks.

Abstract: A biological condition diagnosis system includes, at least: an obtainer, a receiver, a preprocessor, a processor, and a diagnoser, for biological data. The obtainer obtains the biological data by a reflective photoelectric plethysmography sensor. The preprocessor optimally preprocesses the obtained biological data. The processor extracts a feature point from the preprocessed data. The diagnoser diagnoses a biological condition using machine learning, based on the extracted biological data.

Abstract: An apparatus comprising: at least one photoplethysmography sensor configured to determine pulse information of a user; at least one audio sensor configured to determine heart sound information of the user; and means for determining, based, at least in part, on the pulse information and the heart sound information, blood pressure information of the user, wherein the at least one photoplethysmography sensor and the at least one audio sensor are comprised in an ear-worn device.

Abstract: Devices and methods for determining blood pressures are provided. In one example, a device for determining blood pressure of a subject includes a camera configured to measure a finger photo-plethysmography (PPG) waveform, an accelerometer configured to measure a vertical height of the device relative to a heart of a subject, an output device configured to guide the subject to raise a hand to vary the transmural pressure of an artery while maintaining a finger pressure on the camera, and a processor configured to compute pulse pressure of the subject from the finger PPG waveform and the vertical height, and display the pulse pressure on the screen.

Abstract: A device for predicting a heart rate variability parameter for a user. The device including one or more processing modules configured to receive a set of heart rate measurements for a user obtained over a period of time with data indicating a time at which each measurement was obtained during the period of time, process the heart rate measurements to calculate a heart rate variability parameter over the period of time and to estimate whether the set is sufficient for calculating the heart rate variability parameter over the period of time, and to form an uncertainty score representing the result of that estimation, determine whether the heart rate variability parameter is valid by comparing the uncertainty score to a predetermined threshold, and output, in response to a determination that the heart rate variability parameter is valid, the heart rate variability parameter and a representation of the uncertainty score.

Abstract: Methods, systems, and devices for wearable device are described. A wearable device may include a first light-emitting component positioned within an inner circumferential surface of the wearable device at a first radial position and a second light-emitting component positioned within the inner circumferential surface of the wearable device at a second radial position, where the first radial position and the second radial position define a segment of the inner circumferential surface between the first radial position and the second radial position. Additionally, the wearable device may include a photodetector configured to receive light emitted by the first light-emitting component and the second light-emitting component. In some cases, the photodetector may be positioned at a third radial position within the segment of the inner circumferential surface between the first radial position and the second radial position, where the third radial position is offset from a radial midpoint of the segment.

Abstract: A heartbeat information acquisition system (100) configured to acquire heartbeat information of a subject (S) on a bed (BD), including a plurality of load detectors (11, 12, 13, 14) configured to detect a load of the subject on the bed, a waveform acquisition unit (321) configured to acquire, based on outputs of the plurality of load detectors, a plurality of heartbeat waveforms respectively corresponding to the plurality of load detectors, a waveform selection unit (322) configured to select, from the plurality of heartbeat waveforms, a largest amplitude waveform being a heartbeat waveform having a largest amplitude among the plurality of heartbeat waveforms, and a heartbeat information acquisition unit (323) configured to acquire the heartbeat information of the subject based on an output of a load detector, among the plurality of load detectors, corresponding to the largest amplitude waveform.

Abstract: The invention provides devices and methods for measuring microfluidic flow velocity. The novel electrical nanodevice employs a single microelectrode of monolayer graphene and measures in real time at high resolution and stability microfluidic flow velocity by quantifying contact electrification-induced current variations.

Abstract: A novel bioresorbable intracranial pressure sensor fabricated using readily available bioresorbable materials which are compatible with standard microfabrication technology is provided. The intracranial pressure sensor can also stay operational for a relevant time scale and can transfer data wirelessly.

Abstract: A cable for use with a pressure monitoring catheter, the catheter including an inflatable balloon forming a fluid chamber for pressure measurement. The cable has a first end operably connectable to the catheter, a second end operably connectable to a monitor providing pressure displays, and a printed circuit. The cable includes one or both of the filter system to enable collection and analysis of data and an adjustment feature to adjust pressure values in response to patient movement.

Abstract: Methods and systems for sensing a physiological characteristic of a subject. At least one receiver antenna can be provided in proximity to a portion of the subject's body to obtain at least one receiver signal resulting from at least one transmitter signal that has propagated to the receiver antenna and has been reflected, diffracted, scattered, or transmitted by or through the portion of the subject's body. One or more coherent signal pairs can be formed. Then, amplitude and phase information of a plurality of frequency components for each signal pair can be determined. A set of comparison values can be determined for each signal pair by comparing respective frequency component phases and respective frequency component amplitudes of the signals. Physiological characteristics of the subject can then be determined from these comparison values.

Abstract: A physiological parameter inductive sensing system has a loop resonator which inductively couples with electromagnetic signals emitted from the body. The loop resonator forms part of an oscillator circuit, and negative feedback control is used to control the oscillator circuit, based on a measured oscillation amplitude. Within the feedback control loop, an analog to digital converter is used with a first number of bits (or trits), and successive outputs of the analog to digital converter are combined to derive an output value with a resolution of a second number of bits, greater than the first number of bits (or trits). The feedback control of the amplitude of the oscillator circuit is achieved using the output value.

Abstract: A method includes applying an electrical signal to a tissue and measuring an impedance of the tissue based on the applied electrical signal. The method further includes determining information indicative of a stage of wound healing based on the impedance and outputting information indicative of the stage of wound healing.

Abstract: An insertion support system includes a processor. The processor acquires endoscopy status information including at least one of an endoscopic image, insertion section shape information, and operation recognition information. In the processor, at least one of input pain information and endoscopy status information is input, and pain situation information is acquired upon recognition of a pain situation. The processor acquires examination condition information including at least one of endoscope kind information, patient information, and past examination information, the endoscope kind information being information about a kind of endoscope insertion section used for endoscopy, the patient information being information about patient attributes, and the past examination information being information about past endoscopies. The processor generates insertion support information according to the pain situation information, the endoscopy status information, and the examination condition information.

Abstract: A head mounted device includes a housing and a set of one or more SMI sensors. The set of one or more SMI sensors are disposed in the housing. The set of one or more SMI sensors are configured to emit electromagnetic radiation toward an anatomical structure adjacent a nasal passageway of a user and generate one or more SMI signals including information about movement of the anatomical structure.

Abstract: One embodiment is a method of extracting respiratory parameters from a short duration thoracic impedance (“TI”) signal, the method comprising preprocessing the TI measurement signal to obtain a respiratory signal therefrom; assessing the respiratory signal for at least one of signal quality and signal integrity; executing at least one of an autocorrelation algorithm and a time-domain zero-crossing algorithm on the respiratory signal to extract at least one respiratory parameter therefrom, the at least one respiratory parameter comprising at least one of respiration rate (“RR”) and tidal volume (“TV”).

Abstract: A method for guiding deep breathing may include receiving a request from a user to initiate a deep breathing exercise on a user-controlled device. The method may include monitoring deep breathing using one or more sensors on an ear-worn device in response to initiating the deep breathing exercise. Examples of sensors include at least one of a motion detector, a microphone, a heart rate sensor, and an electrophysiological sensor. The method may further include initiating an end to the deep breathing exercise. The method may be used with various hearing systems including an ear-worn device and optionally a user-controllable device, such as a smartphone.

Abstract: Embodiments of the invention are generally directed to using breath measurement to identify certain physiological states, conditions and disorders. In one example, breath measurement may be used in producing a non-binary indicator of the likelihood or extent to which a subject is experiencing or approaching ketosis. Other metabolic or respiratory states may be indicated and/or identified.

Abstract: A head mounted device may include one or more interferometric sensors positioned and oriented in a housing to sense particle movement caused by respiration of a user. Interferometric signals from the one or more interferometric sensors may be used to determine respiration information about the user.

Abstract: A method comprising (a) acquiring sensor data from wearable sensors worn by a subject, wherein the sensor data comprise motion, sound, and/or physiological data; (b) comparing the sensor data with target data; (c) determining: that the motion data of the subject is equal to or exceed the target motion data; that the sound data of the subject is equal to or exceed the target sound data; and/or that the physiological data of the subject is equal to or exceed the target physiological data; and (d) responsive to step (c), delivering audible sound therapy to the subject, wherein the audible sound therapy comprises a familiar audio sound track which is repeated at least until it is determined: that the target motion data exceed the motion data; that the target sound data exceed the sound data; and/or that the target physiological data exceed the physiological data. Steps (b)-(c) can encompass machine learning.

Abstract: A method executed by a computer according to one embodiment includes: extracting a duration time of one or more physical states of a posture or a motion that a person assumes or performs during a performing of a task by analyzing a process of the task of the person; acquiring a load on a body of the person regarding the one or more physical states; and predicting at least one of a fatigue level or a residual physical strength of the person in the task based on the extracted duration time of the one or more physical states and the acquired load.

Abstract: A system for identifying a body position of a user of a respiratory therapy system includes a sensor, a memory, and a control system. The sensor is configured to generate airflow data associated with the user. The memory stores machine-readable instructions. The control system includes one or more processors configured to execute the machine-readable instructions to receive the airflow data associated with the user during a sleep session. The control system is further configured to determine one or more features associated with the airflow data, and identify the body position of the user during a first portion of the sleep session based at least in part on the determined one or more features. The control system is further configured to cause an action to be performed based at least in part on the identified body position of the user.

Abstract: Disclosed are a millimeter-wave (mmWave) radar-based non-contact identity recognition method and system. The method comprises: emitting an mmWave radar signal to a user to be recognized, and receiving an echo signal reflected from the user; performing clutter suppression and echo selection on the echo signal, and extracting a heartbeat signal; segmenting the heartbeat signal beat by beat, and determining its corresponding beat features; and comparing the beat features of the user with the beat feature sets of a standard user group; if the beat features of the user matches one of the beat feature set in the standard user group, the identity recognition being successful; otherwise, being not successful. According to the method, the use of a heartbeat signal for identity recognition has high reliability, and the use of an mmWave radar technology for non-contact identity recognition has high flexibility and accuracy.

Abstract: Various examples are provided related to interstitial fluid (ISF) or extracellular fluid (ECF) harvesting and processing. In one example, a microfluidic monitoring platform includes a microneedle patch including microneedles on a first side; an osmotic patch on a second side of the microneedle patch that includes glycerogel or hydrogel equilibrated with glycerin or glucose; and a microfluidic or fluid transport film or material channel between the osmotic patch and the microneedle patch. The channel can extract fluid from the osmotic-microneedle patch complex. In another example, a wearable electrochemical sensing system includes a monitoring platform including a microneedle-osmotic patch, a microfluidic or fluid transport film or material channel, and at least one sensor between the channel; and processing circuitry coupled to the at least one sensor. The processing circuitry can monitor presence of a chemical or biomarker in the fluid based upon signals obtained from the sensor.

Abstract: Disclosed herein is a method, implemented in an automated drug delivery system for determining a risk of a hypoglycemic or hyperglycemic condition based on risk factors calculated each time a new blood glucose reading is received and providing an alert to the user should a risk be determined. The risk factors may include the current CGM reading, the trend of CGM readings, the amount of insulin-on-board of the user and the accuracy of previous alerts provided to the user. The method may be modified to provide the risk of hypoglycemia if the user were to engage in exercise or other physical activities.

Abstract: A medical system comprising: an analyte sensor for receiving an analyte signal corresponding to an analyte concentration of a user; a health monitor device comprising a display unit and in communication with the analyte sensor, the health monitor device comprising a processor and memory communicably coupled to the processor, the memory including instructions stored therein that, when executed by the processor, cause the processor to: receive the analyte signal from the analyte sensor; determine the analyte concentration based on the analyte signal; calculate a recommended medication dosage based on the analyte concentration; associate a current parameter type with the recommended medication dosage; associate the current parameter type to at least one corresponding stored historical parameter type associated with a historical medication dosage; and display, on the display unit, the recommended medication dosage and the historical medication dosage.

Abstract: A system and method for controlling a pulse oximetry sensor. The pulse oximetry sensor is activated and de-activated according to one or more breathing characteristics of a subject's breathing such that the pulse oximetry sensor acquires pulse oximetry data only at times for which the one or more breathing characteristics indicate that oxygen desaturation is likely to occur.

Abstract: In some examples, a medical system includes a medical device. The medical device may include a housing configured to be implanted in a target site of a patient, a light emitter configured to emit a signal configured to cause a fluorescent marker to emit a fluoresced signal into the target site, and a light detector that may be configured to detect the fluoresced signal. The medical system may include processing circuitry configured to determine a characteristic of the fluorescent marker based on the emitted signal and the fluoresced signal. The characteristic of the fluorescent marker may be indicative of a presence of a compound in the patient, and the processing circuitry may be configured to track the presence of the compound of the patient based on the characteristic of the fluorescent marker.