Abstract: A pharmaceutical container includes an inner surface and an outer surface. At least part of the inner surface is coated with a coating to form a coated inner surface. On the coated inner surface the container, based on negative mode Time-of-Flight-Secondary Ion Mass Spectrometry (ToF-SIMS) data, has a relative lipid nanoparticle (LNP)-incubated Multivariate Curve Resolution (MCR) score ratio of lipid factor1 of less than 0.67.

Abstract: In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components. The device includes a plurality of modules, each including: a body having an interior volume; a spike plate movably disposed in the interior volume, the spike plate having a protruding cannula and first and second ports. The device also includes a base tray which includes: a framework defining a plurality of wells, each of the wells formed to insertingly receive one of the modules; for each of the wells, first and second inlet ports formed to interface with the first and second ports of the module being received in the respective well; passageways to connect certain wells with adjacent wells to permit fluid flow therebetween. For each of the wells, the spike plate of the respective module being maintained in a stationary position with the module being inserted into the well.

Abstract: Some embodiments are directed to a connector for connection with a fluid transfer device, including an outer body having a longitudinal axis; and a luer lock connection port positioned within the outer body and configured to be coupled with an external port of said fluid transfer device. The luer lock connection port can be rotatable about the longitudinal axis at least in one of a clockwise direction and a counter-clockwise direction at least prior to initiation of coupling thereof with the external port. The outer body can be structured, and the luer lock connection port is positioned therewithin, such that to prevent an operator to access, through the outer body, directly by fingertips an exterior of the luer lock connection port after the luer lock connection port has been coupled with the external port.

Abstract: The disclosed apparatus, systems and methods relate to the delivery of personalized nutraceutical products to a subject, comprising a library of actives; a software module; and a dispensing unit. In certain aspects, the system further comprises a packaging unit and a delivery unit. According to certain aspects, the library of actives comprises a plurality of active nutraceutical ingredients formulated for precise dispensing. In further aspects, the software module is constructed and arranged to receive prescription information for the subject and to output dispensing instructions to the dispensing unit. In still further aspects, the dispensing unit is constructed and arranged to receive dispensing instructions from the software module and to dispense one or more actives from the library of actives to form a nutraceutical product, and wherein the dispensing instructions are derived from the prescription information and customized to the nutritional needs of the subject.

Abstract: The present specification describes a medicine dispensing system for automatically dispensing medication at a predetermined time. The system includes a cartridge that carries a strip of medicine pouches. When the cartridge is dropped into a dispensing unit, it automatically aligns with the dispensing unit without requiring any installation work from the user. The automatic alignment is enabled because of self-aligning features manufactured in the cartridge housing.

Abstract: A nasogastic device and method is provided, including a first flexible tube having a distal end configured to be threaded through the nose of a patient, down the esophagus and into the stomach for enteral feeding, a second flexible tube disposed adjacent to the first tube having a distal end proximate to the distal end of the first flexible tube, the distal end of the second tube configured to terminate inside the esophagus for delivery of liquids to the esophagus or for sampling of the local environment, an inflatable balloon configured around the first and second flexible tubes, the inflatable balloon disposed proximal to the distal end of the first and second flexible tubes, a third flexible tube in fluid communication with the balloon configured to inflate the inflatable balloon; and a fourth flexible tube having a distal end portion communicating with an exterior portion of the inflatable balloon, the fourth tube configured to transport suspensions or solutions of materials, such as therapeutic molecules

Abstract: Devices for securing an elongated treatment member to a patient and associated systems and methods are disclosed herein. In some embodiments, the device is configured to secure a medical device comprising a nasally-inserted or an orally-inserted elongated treatment member to a face of a patient. The device can comprise one or more portions configured to be adhered to the patients face and one or more portions configured to secure a length of an extracorporeal portion of the elongated treatment member to the device. The device can comprise an adhesive forming an adhesive bond with the patients skin and the adhesive bond can have an adhesive bond strength sufficient to prevent the patient from prematurely removing the device or the treatment member. A releasing agent can be applied to the device to degrade the adhesive bond strength between the device and the patients skin such that the device can be removed from the patients face without substantial discomfort to the patient.

Abstract: A composition for healing or improving skin includes a fabric or material impregnated with an oxygen generating material. The fabric may include a first side in contact with the skin for providing oxygen to the skin and a second side between the oxygen generating material and the air surrounding the skin to form a barrier for retaining heat and inhibiting evaporation.

Abstract: A film-forming composition for skin, including components (A) and (B): (A) a silicone-based film-forming agent; and (B) a fiber having an average fiber diameter of 0.1 ?m or more and 7 ?m or less in an amount of 0.05 mass % or more and 2 mass % or less relative to the whole film-forming composition. A mass ratio of the component (B) to the component (A), (B/A), is 0.05 or more and 1 or less.

Abstract: The present invention relates to a cosmetic peeling formulation.

Abstract: A composition for caring for keratin materials in the form of an oil-in-water cream comprising: (i) from 3% to 10.5% by weight of at least one cosmetic active compound of formula (I), relative to the total weight of the composition: (I) wherein R1, R2 and R3 are, independently from each other, selected from H, —OH, —CH2OH and —CH2CH(OH)CH3; (ii) at least one water-soluble or water-dispersible copolymer derived from 2-acrylamidomethyl propanesulfonic acid and a nonionic water-soluble comonomer (AMPS copolymer); (iii) at least one silicone compound; and (iv) ethanol. A non-therapeutic method for caring for keratin materials, comprising applying said composition to the keratin materials.

Abstract: An oil-in-water type cosmetic composition, including the following components (A), (B), (C1), and (E): (A) titanium oxide coated with a surface treatment agent including aluminum, (B) a water-soluble polymer having a constitutional unit of sulfonic acid, (C1) an oily compound whose molecule includes one or more hydroxy groups and two or more fatty acid groups having 8 or more carbon atoms or two or more hydrocarbon chains having 8 or more carbon atoms in an amount of 0.6 mass % or more, and (E) a dextrin fatty acid ester.

Abstract: The purpose of the present invention is to provide a novel cosmetic composition or cosmetic quasi-drug which has excellent storage stability. The cosmetic composition or cosmetic quasi-drug comprising: lipid particles containing at least a phospholipid; a polyhydric alcohol; and water, wherein a content of a trihydric or higher alcohol in the polyhydric alcohol is 0 to 20% by mass relative to 100% by mass of the polyhydric alcohol.

Abstract: A method of treating a tooth of a patient includes introducing an oxidizing composition into an oral cavity of the patient such the oxidizing composition contacts the tooth. The method further includes introducing an oral care composition into the oral cavity such that the oral care composition contacts the tooth, wherein the oral care composition comprises an iodide or thiocyanate.

Abstract: The present disclosure generally relates to a particulate composition that includes a particulate source of stannous, alumina, and a drying aid. The disclosure further relates to a method for improving the flowability of particulate stannous by admixing the alumina and the drying aid with it thereby giving improved flow properties to the stannous chloride.

Abstract: According to the present invention, there is provided a non-aqueous cosmetic composition comprising: (A) 15-85% by weight C15-19 alkane; (B) 10-85% by weight C9-13 alkane; (C) One or both of (i) 1-10% by weight isoamyl cocoate, or; (ii) 1-25% by weight cetyl ricinoleate, and; (D) an active, wherein the weight ratio of the active to the rest of the composition is in the range 0.02:100 to 15:100, and the active is selected from: (i) extract of Bidens pilosa; (ii) cyclolinopeptides; (iii) senkyunolides, (iv) sclareolide, or; (v) unsaponifiable fraction of vegetable oil.

Abstract: Disclosed is a personal care composition comprising glycinate surfactant, polyol, and nonionic surfactant comprising alkyl glucoside, wherein the weight ratio of the polyol to the glycinate surfactant is no less than 5.4:1.

Abstract: The present invention relates generally to methods and compositions useful for treating skin, comprising topically applying to the skin of a subject a composition comprising glycerin, butylene glycol, and PEG-32; wherein the skin is treated.

Abstract: The present invention relates to a solid composition intended in particular for washing and/or conditioning keratin fibres, notably human keratin fibres such as the hair, and which comprises a particular combination of at least two anionic surfactants, of which one is of sulfonate type and the other is of carboxylate type. The invention also relates to a packaging article enclosing said solid composition, and also to cosmetic processes for treating keratin fibres, in particular human keratin fibres such as the hair, using said solid composition or said packaging article. The invention also relates to the use of said solid composition or of said packaging article for washing and/or conditioning keratin fibres, in particular human keratin fibres such as the hair.

Abstract: The present invention relates to an anhydrous solid composition comprising one or more anionic surfactants, one or more amphoteric or zwitterionic surfactants and one or more C8-C32 fatty acid salts. The invention also relates to a method for the preparation of an aqueous composition for washing, and optionally in addition conditioning, keratin fibres starting from the anhydrous solid composition according to the invention, to the use of an anhydrous solid composition according to the invention for washing, and optionally in addition conditioning, keratin fibres, and also to a kit for the preparation of the aqueous composition for washing, and optionally in addition conditioning, keratin fibres.

Abstract: The present invention is directed to a hair care composition having an effective amount of a 2-pyridinol-N-oxide material and an effective amount of an iron chelator; wherein the combination of the iron chelator and the 2-pyridinol-N-oxide material provides high anti-fungal efficacy.

Abstract: Compositions and methods are disclosed herein for inducing (up-regulating) the expression of sulfotransferases in the hair follicles, e.g., the scalp. Increasing sulfotransferase is beneficial for metabolizing pro-drugs that require sulfonation to be activated, e.g., minoxidil sulfate is the active metabolite of minoxidil. A method for combining the compositions described herein with topical minoxidil to enhance minoxidil treatment for androgenetic alopecia is described. Additional methods and compositions include the use of retinoid X receptor agonists, retinoic acid receptor agonists, and nuclear receptor agonists in an RXR-NR heterodimer. Additional methods and compositions include the use of a topical solution containing an alkalinizing agent or an alkalinizing agent used with a penetration enhancer for up-regulating the sulfonating capacity of hair bearing skin, hair follicles, and/or keratinocyte cells.

Abstract: The present invention relates to specific topical compositions comprising bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT), butyloctyl salicylate and at least one inorganic UV-filter selected from titanium dioxide and zinc oxide. Said compositions exhibit an appealing skin feel and look.

Abstract: The present invention relates to cosmetic composition comprising an ester of a fatty acid and dextrin, a mixture of branched and linear saturated C15-C19, wherein said mixture comprised primarily branched saturated C15-C19, and a UV-filter of the formula (I). This cosmetic composition allows a high amount of the UV-filter of the formula (I) to be solubilized which leads to compositions having a very high absorbance of harmful UV light, i.e. to compositions having a high Sun Protection Factor (SPF).

Abstract: A process of extraction of anthocyanins from different foodstuffs or by-products, and their conversion into pyranoanthocyanins compounds, which can be used as pigments having new colors and improved stability to be incorporated into skincare formulations in particular anti-ageing and sun-protection formulations. Cosmetic formulations having the pigments with improved properties of UV protection and moisturizing, anti-dark spots, anti-wrinkles and wound-healing, which can be associated with interesting colors ranging from red to blue depending on the selected pigments in the composition and in the formula composition. The present invention is in the area of organic chemistry, biochemistry, pharmacology and cosmetics for skincare.

Abstract: According to the present invention there is provided a peptide combination, capable of inducing dermal extracellular matrix protein upregulation, comprising; a) a first peptide selected from the group consisting of tetrapeptides having the amino acid sequence U-LSXX-Z; and b) a second peptide selected from the group consisting of tetrapeptides having the amino acid sequence U-GPXG-Z.

Abstract: The present invention teaches a hair straightening system including formulations that will safely and effectively straighten curly hair for at least 2-3 months after a single application, despite frequent washings of the hair. Methods for obtaining said formulations are disclosed. Hair straightening systems including shampoo and one or more conditioners are also provided.

Abstract: Disclosed are a hyaluronic acid composition having permeation-promoting effects, a preparation method thereof and the use thereof. Provided is a hyaluronic acid composition, comprising: hyaluronic acid or a salt thereof, an acetylated hyaluronic acid or a salt thereof, and a hydrolyzed hyaluronic acid or a salt thereof. The hyaluronic acid composition of the present application has a small addition amount, can effectively facilitate the absorption of other active ingredients in a formula to achieve synergistic effects, has a small particle size, is uniform, has a fast dissolution rate, has an excellent absorption speed in a product, and is superior to hyaluronic acid treated by means of simple mixing in improving skin hydration. Compared with traditional penetration promoters, the hyaluronic acid composition of the present application causes no damage to the skin and is safe.

Abstract: The present disclosure is directed to new cosmetic compositions comprising (a) at least a polymer, (b) at least a polyamide, (c) at least a filler, (d) at least a fatty compound and (e) at least a nonionic surfactant. The composition of the present invention is stable over the time, also presents a high level of UV-protection in order to protect the skin from the damages of the sun, easy application, good spreadability, very pleasant sensorial, skincare signature, dry touch, mate effect, soft focus effect and light sensorial feeling.

Abstract: The disclosure relates to natural oil-based petrolatum compositions and a method of making the same. The natural oil-based petrolatum composition includes the esterification product of: about 5 wt % to about 35 wt % a fatty acid dimer, about 20 wt % to about 55 wt % a C8 to C22 fatty acid substituted with one or more C1-C3 alkyl substituents, about 10 wt % to about 20 wt % glycerin, and about 20 wt % to about 40 wt % hydrogenated natural oil, wherein the natural based petrolatum product has an acid value of less than 10. Natural oil-based petrolatum compositions can be used in personal care products.

Abstract: The present invention relates to an association of a Vichy thermal water and an extract of at least one bacterium from the species Vitreoscilla filiformis cultured on a medium comprising at least one Vichy thermal water, to a composition comprising said association, to a cosmetic treatment process comprising the application to keratin materials of said cosmetic composition for caring for keratin materials, in particular the skin; and also to the cosmetic use of said association for caring for keratin materials, in particular the skin.

Abstract: The invention relates to a process for obtaining aqueous extracts of tea leaves (Camellia sinensis), in particular of leaves of fresh tea, pu'er tea, matcha tea or green tea. The invention also relates to tea extracts enriched with small RNAs, sugars, phenolic compounds, organic acids, theine and theanine, as well as to cosmetic compositions comprising such extracts and their cosmetic uses for the care of the skin, the scalp, and the appendages and more particularly for protecting the skin from external aggressions and oxidation, combating the signs of skin ageing, increasing photoprotection, lightening the skin and improving skin hydration.

Abstract: A method for topically treating skin is disclosed. The method can include applying to skin a composition that includes tetrahexyldecyl ascorbate, Morus alba fruit extract, Acmella oleracea extract, and retinol, wherein topical application of the composition treats the skin.

Abstract: Disclosed is a method of treatment of a disease associated with abnormal protein aggregation comprising parenterally administering pharmaceutical formulations comprising trehalose. Also disclosed is an injectable aqueous pharmaceutical formulation comprising a therapeutically effective amount of trehalose.

Abstract: The present invention provides a mRNA composition for microneedle administration and its application. The composition includes an aqueous phase solution and a lipid solution, wherein the lipid solution encapsulates the substance in the aqueous phase solution to form lipid nanoparticles (LNPs), and the aqueous phase solution includes mRNA encoding the corresponding protein and a buffer. It was found that an improved buffer pH could substantially increase the drug loading capacity of LNPs, and reduce the use level of composition and excipients and the dose for microneedle administration with less toxic side effects and better therapeutic effects, and the microneedle administration technology could achieve increased effective expression, decreased expression in the liver, and prolonged in vivo expression of mRNA composition, and increased antibody titer in response to low-dose mRNA in vivo. The present invention really realizes microneedle intradermal administration of mRNA composition.

Abstract: The present invention relates to thermogelling peptide delivery systems which are injected as fluid sol at ambient temperature through thin injection needles and transform into a highly viscous gel once inserted into human or animal body warm tissue. In a preferred embodiment said system is based on the use of a hydrophobic peptide, a chitosan and a glucose-phosphate.

Abstract: The invention is describing an intrauterine delivery system comprising non-steroidal anti-inflammatory (NSAID) and a progestogenic compound, containing anti-inflammatory active compound in the frame material and that the progestogenic compound is contained in a silicon based reservoir attached to the frame, wherein the frame consist of a thermoplastic material. A further object of the invention is to fabricate drug-containing T-intrauterine systems (IUS) with the drug incorporated within the entire backbone of the medical device by using 3D printing technique, based on fused deposition modelling (FDM™). Indomethacin was used to prepare drug-loaded poly-caprolactone (PCL)-based filaments with different drug contents 5-40 wt %, namely 5%, 15% and 30% wt %:of Indomethacin.

Abstract: Compositions for transmucosal administration of active pharmaceutical ingredient (API) are disclosed. More specifically, the formulations of the present invention provide an intranasal administration which can exhibit a rapid high plasma concentration. The formulations of the present invention comprise an API and penetration enhancing agents which facilitate the penetration of said API through the mucosa. Methods for improved treatment of conditions by administration of said formulations having enhanced penetration via the mucosa are also disclosed.

Abstract: The invention provides a method for vaccinating one or more avians in need thereof. The vaccination method comprises administering to the one or more avians a stable foam in an amount effective for inducing a neutralizing immune response against an infectious pathogen in the one or more avians. The foam comprises a gas and a liquid, and the liquid comprises a vaccine and a foaming agent. The avian may be a chick. Also provided is a method for preparing the stable foam.

Abstract: A rapidly infusing composition that includes a pharmaceutically acceptable binder and/or excipient system containing mammalian gelatin and a sugar alcohol, and at least one supplement selected from the group consisting of a vitamin D compound, vitamin A, vitamin E, vitamin K, vitamin B, vitamin C, and caffeine. Also disclosed is a method of providing nutrient supplementation/modulation and/or a stimulant effect to a subject, whereby the subject in need thereof is administered, via the oral mucosa, the rapidly infusing composition.

Abstract: Methods and pharmaceutical compositions for delivering a therapeutic agent, treating a neovascularization disorder, and treating an ocular infection include make use of a compound that includes an elastin-like polypeptide (ELP) coupled to a therapeutic agent, wherein the ELP comprises at least one repeat of the amino acid sequence VPGXG (SEQ ID NO: 1), and where the composition is suitable for ocular administration.

Abstract: Disclosed herein is a method and an extended-release aqueous suspension pharmaceutical composition and its use thereof.

Abstract: A pharmaceutically nanoemulsion formulation of Compound 1 is disclosed along with methods for making the same. An example embodiment of the nanoemulsion of Compound 1 is comprised of lecithin, medium chain triglycerides (MCT), sucrose, EDTA and water.

Abstract: A method for preparing a nutritional multi-supplement complex, the method comprising: (i) preparing a dispersion of spheroidal polysaccharide-stabilized complexes comprising a water-soluble polysaccharide and at least one water-soluble nutritional supplement in an aqueous medium, wherein the water-soluble polysaccharide and water-soluble nutritional supplement are complexed with each other by ionic interactions in the spheroidal polysaccharide-stabilized complexes; (ii) preparing an oil-supplement solution comprising at least one oil-soluble nutritional supplement dissolved in a food grade oil; and (iii) blending the dispersion of spheroidal polysaccharide-stabilized complexes with the oil-supplement solution to produce the nutritional multi-supplement complex, wherein the nutritional multi-supplement complex comprises droplets of the oil-supplement solution encapsulated by the spheroidal polysaccharide-stabilized complexes.

Abstract: An ophthalmic suspension contains a micro-fluidized positively charged nanoparticle incorporated into a viscous hydroxypropyl methylcellulose (HPMC) base. Positive charges on the surface of the nanoparticle ensure dispersion within solution while the viscosity prolongs the contact time with the ocular surface.

Abstract: A system for producing a gas-filled medium comprises a first pressurized vessel containing a gas, a second vessel containing a surfactant solution, a dose chamber in fluid communication with the first pressurized vessel, a mixing chamber in fluid communication with the dose chamber and the second vessel, the mixing chamber being configured to mix the gas flowing out of the dose chamber and the surfactant solution flowing out of the second vessel to produce a gas-filled solution, and a foaming nozzle comprising mesh screens configured to convert the gas-filled solution into a gas-filled foam medium, the foaming nozzle configured to discharge the gas-filled foam medium.

Abstract: A PN composition for treating multiple organ dysfunction syndrome (MODS) comprises a lipophilic or hydrophobic component, an amphiphilic emulsifier, a polar liquid carrier, and one or more electrolytes, where the amphiphilic emulsifier forms micelles having a lipophilic or hydrophobic core comprising the lipophilic or hydrophobic component in the polar liquid carrier, and/or liposomes organized as a lipid bilayer and/or other particle configurations. This is a PN composition that takes up nitric oxide and releases it with enhanced rapidity enabling it to shift the balance of nitric oxide from one that exacerbates organ damage and decreased survivability to one that reverses and/or inhibits organ damage and increases survivability.

Abstract: Methods and compositions are described for the introduction of nutritional support material and optional waste scavenging material at the site of tissue injury, disease, surgery, or wound. These methods and compositions are useful for the purpose of optimizing the tissue healing environment at the site of tissue injury, disease, surgery, or wound.

Abstract: Pharmaceutical formulations, methods for spray drying pharmaceutical formations, and systems for spray drying pharmaceutical formulation are provided. In one example, a method for spray drying a pharmaceutical formulation may include selecting a solvent mixture comprising a low volatility solvent based on a solubility of a drug of the pharmaceutical formulation in the solvent mixture, forming a solution of the drug of the pharmaceutical formulation in the solvent mixture, and spray drying the solution using a spray drying mass ratio that is selected based on a relationship between a glass transition temperature of the pharmaceutical formulation and a relative saturation of the low volatility solvent during the spray drying, the spray drying mass ratio defining a liquid feed rate of the solution to a gas feed rate of a drying gas, and using a process outlet temperature that is less than the glass transition temperature of the pharmaceutical formulation.

Abstract: A container for a lyophilized rapidly infusing composition is described. The container comprises a planar lidding layer attached to a well layer comprising pockets for the therapeutic product. The lidding layer may comprise an aluminum layer, a thermoplastic polymer layer, and a labeling layer. The well layer may comprise an aluminum layer, two polyamide layers, and two thermoplastic polymer layers. A drug product assembly is also disclosed, which includes at least one therapeutic product sealed within the at least one pocket of the container.