Abstract: An elongated guidewire for use in angioplasty and related procedures. The guidewire includes a proximal section and a distal section. The proximal section has a plurality of round cross-section segments alternating with a plurality of non-round cross-section segments. The non-round cross-section segments can include a square, rectangle, pentagon, triangle, octagon and polygon.

Abstract: A guidewire comprising a hydrophilic surface coating encasing a core and a metal coil along a longitudinal length of the hydrophilic surface coating to form a distal closed tip, the metal coil circumscribing the core along a predetermined length, the core extending longitudinally beyond the metal coil in both a proximal direction and a distal direction, wherein a proximal section of the guidewire includes a hydrophobic surface coating.

Abstract: A method of manufacturing a safety catheter includes providing a catheter having a catheter body comprising an exterior surface, a drainage lumen, and an inflation lumen, forming a balloon inflation port between the exterior surface and the inflation lumen, forming a deflation port between the exterior surface and one of the inflation and drainage lumens, fixing a balloon sleeve to the exterior surface over at least the balloon inflation port to define a fluid-tight balloon interior between an interior surface of the balloon sleeve and at least a portion of the exterior surface, removably inserting a deflation plug in the deflation port to water-tightly seal the deflation port until the deflation plug is removed, connecting a proximal portion of a deflation connector to an inside surface of one of the lumens, and connecting a distal portion of the deflation connector to the deflation plug.

Abstract: The invention features methods for continuously administering a drug by oral infusion (e.g., via a drug delivery device anchored in the mouth for continuously administering a pharmaceutical composition), and pre-screening subjects and, if necessary, treating subjects with H. pylori to improve the PK performance of the continuous intraoral administration in the subject.

Abstract: Systems, methods and apparatus for genital and anal pre-cancer treatment and the treatment of cervical intraepithelial neoplasia are disclosed. One aspect includes an applicator for topically applying a therapeutic agent. The applicator includes a container to store the therapeutic agent. The applicator further includes an actuator configured to release the therapeutic agent from the container. The applicator further includes a tip configured to absorb the therapeutic agent released from the container, the tip further configured to release the therapeutic agent to a treatment area in response to contact between the tip and the treatment area. Another aspect includes an applicator for applying a film containing therapeutic material.

Abstract: A microstructure is provided. The microstructure includes a base film and a plurality of microneedles formed on one surface of the base film, wherein the microneedles may each include: a needle body; and support wings which are disposed in a plurality around the needle body, connect the outer surface of the needle body and the base film, and have a smaller thickness than the needle body.

Abstract: In a method for enhancing localized delivery of a diagnostic or therapeutic agent using focused ultrasound (FUS), ultrasound-controllable drug carriers are administered into a blood vessel. Each drug carrier comprises an ultrasound-sensitive microbubble loaded with the diagnostic or therapeutic agent. The drug carriers are aggregated inside the vessel both along a radial direction and a longitudinal direction by application of an aggregation FUS sequence. Subsequently the diagnostic or therapeutic agent is released from the drug carriers by application of an uncaging FUS sequence. The aggregation and uncaging sequences are applied using FUS below a threshold power level such that harmful cavitation is avoided, as evidenced by the absence of broadband emissions and preferably non-integer harmonics from an emission spectrum of the drug carriers. Thereby damage to the vasculature by the FUS sequence is avoided.

Abstract: A device for implantation into a mammalian host has a dialysis tube with a lumen and a dialysis membrane enclosing the lumen. The dialysis tube has an outer diameter of 20 ?m to 600 ?m. The dialysis membrane has a molecular weight cutoff of from 25 kDa to 150 kDa and has a material composition of at least one of the following: polyethersulfone, polyarylethersulfone, polyethylene, polytetrafluoroethylene, polyvinylidene fluoride, and polypropylene. A therapeutic composition is disposed within the lumen and has cells that secrete a therapeutic compound. A matrix material embeds the cells. The matrix material is one or more of alginate, collagen, fibrin, extracellular matrix material, synthetic hydrogel, and acrylate. Also disclosed are a method of producing a device for implantation, a port system, and a cell secreting a therapeutic compound for use in treating disease by implantation of the cells in a device for implantation.

Abstract: Devices and methods for fistula-free vascular access for hemodialysis are disclosed. In exemplary embodiments, devices are provided comprising a transcutaneous access port (200) for needlelessly connecting a patient to a dialyzer, said port having different inner lumen profiles for arterial or venous blood flow and further comprising an intracorporeal conduit providing a fluid path between said transcutaneous port and a blood vessel, wherein said conduit has a distal more rigid segment attached to a device anchor (400), said device anchor having distal and proximal self-expandable segments for anastomosing said conduit to a blood vessel. An exemplary fistula-free hemodialysis method (100) provided herein consists of percutaneously deploying a first intracorporeal conduit in an artery and a second intracorporeal conduit in a vein and independently connecting each of said conduits to the arterial and venous lines of a dialyzer using said transcutaneous access ports.

Abstract: The present disclosure relates to a subdural evacuation port device for evacuating the subdural space of a patient. The device includes a body that includes: a distal opening at a distal end, a primary evacuation opening at a proximal end, a skull engagement region that at least partially surrounds the distal end of the body, and a primary lumen extending from the distal opening to the primary evacuation opening. The skull engagement regions is also configured to engage with a skull of a patient. The body is formed from a polymer that is sufficiently rigid to sustain suction in the lumen to allow withdrawal of subdural fluid from the distal opening through the primary lumen to a suction device connected to the primary evacuation opening.

Abstract: A locking mechanism for a connector to an implantable controller includes a housing of the implantable controller defining a housing bore sized to receive the connector. A set screw is releasably coupled to the housing and disposed at an oblique angle with respect to the housing, the set screw being configured to engage at least a portion of the connector when the set screw is fully inserted within the housing to lock the connector within the housing.

Abstract: A valve system comprises a first valve plunger configured for insertion into a first valve plunger channel. The first valve plunger has a first latch member disposed at a distal end. A first sealing member and a first valve are opening disposed proximally from the first latch member. The valve system also comprises a second valve plunger configured for insertion into a second valve plunger channel. The second valve plunger includes a second valve opening that is longer than the first valve opening. The valve system also includes a valve body having the first and second valve plunger channels. The first and second valve plunger channels are configured to receive the first and second valve plungers, respectively.

Abstract: A percutaneous assembly is provided with a percutaneous sheath and a percutaneous dilator tip. The percutaneous sheath has a tubular wall extending to a distal end portion thereof and defines a lumen having an inner diameter. The percutaneous dilator tip includes a radially expandable member and an elongated control member. The radially expandable member is either removably engageable or fixedly attached to the distal end portion of the tubular wall and is also adjustable in an expanded and a contracted configurations. The elongated control member is disposed longitudinally along the tubular wall, positioned eccentrically relative to the lumen, and is operatively coupled to the radially expandable member for adjusting same in at least one of the expanded and the contracted configurations. A percutaneous sheath is also provided as kits.

Abstract: A system for assisting a circulation of blood inside a body of a patient includes a pump including: a housing having an upstream portion and a downstream portion; an inducer positioned in the upstream portion of the housing, the inducer including one or more helically-wound inducer blades to rotate around a longitudinal axis of the pump; an impeller positioned downstream of the inducer in the housing, the impeller including one or more impeller blades to rotate around the longitudinal axis of the pump; and a diffuser positioned in the downstream portion of the housing, to direct blood through at least one aperture in a circumference of the housing.

Abstract: A total artificial heart system includes: at least one artificial ventricle coupled to (or capable of being coupled to) a chamber or a vessel of a human heart, and at least one drive system coupled to the artificial ventricle, the drive system including at least one implanted electric motor. The drive system causes the artificial ventricle to contract and expand.

Abstract: A peristaltic pump includes a housing and a rotor that rotates about a rotor axis. The rotor has a rotor body and a pump. The housing has a cut-out in which the rotor is accommodated and a support surface extending about the rotor axis. The support surface supports a tube segment that is introducible between the rotor and support surface. The rotor has a first element for manually actuating the rotor and a first portion for applying a manual rotation actuation force. The first element is mounted on the rotor body and is movable relative to the rotor body between a first position, in which the first portion is spaced from the rotor axis by a first length, and a second position, in which the first portion is spaced from the rotor axis by a second length, the second length being greater than the first length.

Abstract: A heat exchange system for controlling the temperature of the blood of a patient. The heat exchange system comprises a disposable component having a blood inlet to receive blood from the patient and a blood outlet to return blood to the patient, and a permanent component. The permanent component includes a first housing having an inlet and an outlet to exchange thermal fluid with an external device and a second housing having an inlet and an outlet to exchange thermal fluid with the external device. The disposable component is inserted between the first housing and the second housing, such that in a closed position of the permanent component, a first surface of the disposable component is pressed into contact with a surface of the first housing and a second surface of the disposable component is pressed into contact with a surface of the second housing.

Abstract: A defibrillation system having a paddle assembly with a paddle head and handle. The paddle head includes an enlarged support pad that is attached to the handle via a flexible neck. Both the enlarged support pad and the neck are formed from a thermoplastic elastomer and are highly flexible. A contact electrode is attached to the enlarged support pad. The contact electrode conducts electrical current to the heart. The contact electrode is thin and can deform with the enlarged support pad. The contact electrode receives electrical current through a conducive core element. The conductive core element extends through the handle and into the flexible paddle head, wherein the conductive core element is electrically coupled to the contact electrode via a terminal lead within the flexible paddle head.

Abstract: A device and method consisting of conductive, non-conductive, and support materials. These materials when dispensed or extruded onto a multitude of temporary structures will create an implantable conductive and non-conductive structure suitable for neurological electrical stimulation and neurological electrical recording. This structure may also be suitable for delivering fluid and/or contain optical structures suitable for physiological sensing.

Abstract: A device and method consisting of conductive, non-conductive, and support materials. These materials when dispensed or extruded onto a multitude of temporary structures will create an implantable conductive and non-conductive structure suitable for neurological electrical stimulation and neurological electrical recording. This structure may also be suitable for delivering fluid and/or contain optical structures suitable for physiological sensing.

Abstract: The present disclosure relates to an EMS method using EMS electrode pads. Each electrode may be provided to correspond to the shape and size of the divided area according to the virtual line. The EMS method using the same according to the present invention may minimize the edge current effect by the shape of the electrode to which electric energy is applied. In addition, energy transfer efficiency may be improved by capacitive coupling between the electrode and the skin. In addition, due to the coating of the electrode, a rate of contact with an affected part may be increased so that current may be applied evenly to each part.

Abstract: Electrical stimulation devices and associated systems and methods are disclosed herein. In some embodiments, the electrical stimulation device comprises a first elongate member having a closed distal end and one or more first conductive elements and a second elongate member having one or more second conductive elements. The second elongate member can be configured to be received within a lumen of the first elongate member such that the first and second conductive elements are aligned and in electrical communication. The device can be configured to be inserted transnasally into a pharynx of a patient and current can be applied from an electric current generator to the second conductive elements, from the second conductive elements to the first conductive elements, and from the first conductive elements to the patient's pharynx.

Abstract: A method of forming a nerve cuff by combining a plurality of electrically conductive members with respective rear surfaces and grit blasted front surfaces with a nerve cuff body, which includes a respective plurality of windows, in such a manner that exposed portions of the grit blasted front surfaces are within the windows.

Abstract: A lead distal tip for a pacemaker includes a lead body including an insulated wire having a diameter of 2 French or less. The small size and flexibility of the lead distal tip and lead body reduce penetration and dislodgement risk for the lead distal tip. The lead distal tip can be delivered using a delivery catheter engaging with features on the lead distal tip to allow for the guidance and securement of the lead distal tip, despite its small and flexible nature. The attachment of the lead distal tip to heart tissue can be achieved by extending a linear member and/or a helical member from an end of the lead distal tip using features provided on the delivery catheter.

Abstract: An apparatus for controlling a flow of sperms in a uterine tube formed by a uterine tube wall of a patient's uterine tube comprises an implantable constriction device for gently constricting (i.e. without substantially hampering the blood circulation in the uterine tube wall) at least one portion of the uterine tube wall to influence the flow in the uterine tube, and a stimulation device for stimulating the wall portion of the uterine tube wall. A control device controls the stimulation device to stimulate the wall portion, as the constriction device constricts the wall portion, to cause contraction of the wall portion constricted by the constriction device to further influence the flow in the uterine tube. The apparatus can be used for restricting or stopping the flow in the uterine tube, or for actively moving the fluid in the uterine tube, with a low risk of injuring the uterine tube.

Abstract: An implantable electrical stimulation (IES) system and a method thereof, is disclosed. The implantable electrical stimulation (IES) system may comprise an implantable electrode array having a plurality of electrode contacts, an electrical stimulus means, a sensor and a processing circuitry. The electrical stimulus means may be configured for applying the electrical stimulus to at least one stimulating electrode contact of the implantable electrode array. The sensor may be configured for sensing and determining a measured ECAP of the at least one stimulating electrode to generate data for determining a plurality of parameters for the at least one stimulating electrode of the implantable electrode array. The processing circuitry may be configured for processing the measured ECAP and plurality of parameters of the at least one stimulating electrode of the implantable electrode array to compute the corresponding parameters for the remaining electrode contacts of the implantable electrode array.

Abstract: This disclosure relates to medical implant systems and apparatuses capable of treating a seizure condition through the use of recording and stimulating electrodes. The apparatus includes an internal pulse generator in communication with a wireless communication module; one or more recording electrodes in communication with the internal pulse generator, wherein the one or more recording electrodes are configured to monitor to detect one or more field potentials produced by neural tissue in proximity to the one or more recording electrodes; one or more stimulating electrodes in communication with the internal pulse generator, wherein the one or more stimulating electrodes are configured to stimulate the vagus nerve.

Abstract: Various embodiments of a system and associated methods for facilitating a noninvasive stimulation protocol that targets corticospinal-motoneuronal synapses of multiple upper and lower limb muscles simultaneously using principles of spike-timing dependent plasticity. The system applies pre-synaptic and post-synaptic stimuli to cortico-neuronal pairs during each session of the stimulation protocol for rehabilitation of multiple peripheral nerves at a time. The system includes a controller that modulates a post-synaptic pulse initiation time such that an interstimulus interval between an arrival time of a pre-synaptic stimulus and an arrival time of a post-synaptic stimulus is within a predetermined range.

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

Abstract: Disclosed herein is a neurostimulation system for treating head pain, the system comprising: an implant unit configured for implantation inside a subject's (700) body; an external unit configured for a location external to the subject's (700) body; and a charging and programming unit; wherein the external unit comprises: a processor; a power source (220); and a primary transmission unit (230) in electrical communication with the power source (220) and the processor; wherein the implant unit comprises: at least one lead (310); at least one pair of modulation electrodes (320) attached to the at least one lead (310); and a secondary transmission unit (330) in electrical communication with the at least one lead (310); and wherein the processor is configured to establish a coupling between the primary transmission unit (230) and the secondary transmission unit (330) and to transmit power from the power source (220) to the implant unit via said coupling.

Abstract: Techniques for treating acute ischemic stroke, and other neurological pathologies, are described herein. An example method includes identifying a portion of a brain including overactive neurons and outputting an electrical signal to at least one stimulation electrode disposed away from the portion of the brain by a distance in a range of about 0.5 mm to 1 cm. The electrical signal includes a low-frequency component including bursts having a frequency in a range of about 2 Hz to about 10 Hz. The electrical signal includes a high-frequency component comprising pulses having a frequency in a range of about 200 Hz to about 2 kHz.

Abstract: Various embodiments of systems and methods for implantable electrode recording of an alternating electric field are disclosed herein. In particular, the system enables interradial distance-based recording of electric field differential resultant from an applied waveform between various locations within an organic structure. The determination of electric field differential between measuring contacts can enable a practitioner to create a mapping of electric field differential throughout an organic structure that can aid in understanding of how structural and material variability throughout the bodily structure affects electric field propagation through the structure.

Abstract: Disclosed herein are methods, systems, and apparatus for treating a medical condition of a patient, involving detecting a physiological cycle or cycles of the patient and applying an electrical signal to a portion of the patient's vagus nerve through an electrode at a selected point in the physiological cycle(s). The physiological cycle can be the cardiac and/or respiratory cycle. The selected point can be a point in the cardiac cycle correlated with increased afferent conduction on the vagus nerve, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during inspiration by the patient. The selected point can be a point in the cardiac cycle when said applying increases heart rate variability, such as a point from about 10 msec to about 800 msec after an R-wave of the patient's ECG, optionally during expiration by the patient.

Abstract: Examples for controlling electrical stimulation therapy are described. One example includes delivering a pulse train at a frequency to a patient, the pulse train comprising a plurality of first pulses at least partially interleaved with a plurality of second pulses, wherein the plurality of first pulses are configured to facilitate sensing elicited electrical signals, each pulse of the plurality of first pulses having an active first phase and active second phase. Each pulse of the plurality of second pulses may include an active first phase and a passive second phase. Additionally, or alternatively, the plurality of second pulses may alternate between a cathodic active first phase and an anodic active first phase according to a ratio. At least one pulse of the plurality' of second pulses may have an interphase interval that is longer than an interphase interval of at least one pulse of the plurality of first pulses.

Abstract: Embodiments regard innovations for implantable electrostimulation devices and corresponding systems that operate using or contain the implantable electrostimulation devices. A system can include an implantable electrostimulation device. The system can further include an introducer configured to deliver the electrostimulation device to a target location inside a patient body. The introducer can comprise a migration mitigation component configured to couple with the electrostimulation device.

Abstract: Systems and methods that automatically adjust, or adapt, stimulation waveforms delivered to brain structures. Closed loop system embodiments can automatically be re-configured into a more suitable closed loop control system in response to measures of control system performance. Measures can be internal performance characteristics of the adaptive control system or external inputs provided by another subsystem. As these measures change in time, the robust adaptive system changes in response.

Abstract: Implantable medical devices (IMDs) described herein, and methods for use therewith described herein, reduce how often an IMD accepts a false message and/or reduce adverse effects of an IMD accepting a false message. Such IMDs can be leadless pacemakers (LPs), or implantable cardio defibrillators (ICDs), but are not limited thereto. Such embodiments can be used help multiple IMDs (e.g., multiple LPs) implanted within a same patient maintain synchronous operation, such as synchronous multi-chamber pacing.

Abstract: An implantable medical device including a first patch for electrical stimulation and/or electrical sensing of human or animal soft tissue is disclosed. The first patch includes a felt material. The felt material has a multitude of fibers that are entangled with each other. The felt material is suitable to be felted with fibers of human or animal soft tissue. The first patch includes fibers that are electrically conductive such that the soft tissue can be electrically stimulated and or electrical signals of the soft tissue can be sensed.

Abstract: Leadless pacemakers and methods of implanting the same are provided for a cardiac conduction system. A leadless pacemaker includes an implantable housing including a mounting interface, an electronic circuitry and a power source received by the implantable housing, and an electrode system connected to the electronic circuitry via the mounting interface. The electrode system includes electrodes configured to insert into a septum and having a length to reach pathways of the cardiac conduction system.

Abstract: A system for determining an estimate of a battery capacity for the battery of an implantable device that is used over a period of time. The system includes an external device having a processor that is configured to communicate with the implantable device. During the initial phase, the processor is configured to determine the estimate of the battery capacity using battery energy consumption data and a battery capacity at the beginning of use. During the latter phase, the processor is configured to determine the estimate of the battery capacity based on the battery voltage. The system may include an intermediate stage and, during the intermediate phase, the processor is configured to determine the estimate of the battery capacity based on the battery energy consumption data and the battery voltage.

Abstract: An active implantable medical device (AIMD), for electrical stimulation of a tissue includes a light source, lodged in an encapsulation unit, for delivering optical energy pulses of optical power (Popt). A stimulation optical fibre for transferring optical energy from the light source of the encapsulation unit to the tissue coupling unit is also provided. The tissue coupling unit is configured for being coupled to a tissue to be electrically stimulated by electrodes (65) belonging to an electrical circuit. The PV-unit includes Us units arranged in series, each unit having Pp photovoltaic cells (PV-cells) arranged in parallel. Us and Pp, ?, and Us×Pp=N=constant. The electrical circuit includes switches configured for varying the values of Us and alternatively or concomitantly, the light source is an addressable optical emitters array.

Abstract: A device to emit ultrasounds to wireless recharge an electronic device, wherein the emitting device includes at least one ultrasonic transducer and an electronic circuit to control the ultrasonic transducer, wherein the control electronic circuit is configured to: apply to the transducer an excitation electric signal in order to induce the emission of an ultrasonic wave towards the electronic device; and read a feedback electric signal generated by the transducer under the action of a part of the ultrasonic wave reflected by the electronic device, wherein the control electronic circuit comprises a feedback loop configured to adjust the frequency of said ultrasonic wave, so that the energy of said reflected part of the ultrasonic wave tends to a minimum value.

Abstract: An external charging system for an Implantable Medical Device (IMD) is disclosed having a thermal diffuser proximate to the primary charging coil for distributing heat from the primary charging coil. In an example, the primary charging coil is mounted to a first side of a circuit board, and the thermal diffuser is also connected to the first side and in contact with the primary charging coil. In one example, the thermal diffuser is a plastic material, such as an acrylic pad, with a high thermal conductivity and a low electrical conductivity. The thermal diffuser may also contact temperature sensors mounted to the first side of the circuit board.

Abstract: The invention provides method, device, and system to commission medical devices using different wireless communication protocol or from different manufacturers to a network by introducing a pairing device and a guiding device. The commissioning process includes two steps, e.g., a pairing the medical device to the pairing device and a pairing between the pairing device and server of the network. By configuring a pairing device dynamically with the aid of a guiding device, the pairing device can receive broadcast messages from medical devices using different communication protocols and send the same to a remote server having a specific network address. Further, the guiding device is introduced not only to assist in the configuration of the pairing device, but also provide an opportunity to the pairing device to obtain a real-time feedback from the remote server through the guiding device during installation.

Abstract: A device for monitoring operation of a probe of an implantable active cardiac device, in particular an implantable automatic defibrillator or a defibrillator for cardiac resynchronization. The device comprising a parameter-determining device for determining values of a plurality of parameters characterizing the probe, and a processing unit configured to determine representative values that are representative of at least one parameter of the plurality of parameters characterizing the probe based on at least two different time scales. The processing unit is further configured to compare an analysis value of the at least one parameter of the plurality of parameters characterizing the probe with the representative values of the at least one parameter.

Abstract: A transducer apparatus for delivering tumor treating fields to a subject's body, the transducer apparatus including: an array of electrodes, the array configured to be positioned over the subject's body with a face of the array facing the subject's body, the array including electrode elements positioned in existing electrode positions arranged around a centroid of the array; at least one void space in the array capable of enclosing an areal footprint equivalent to at least 40% of an areal footprint of at least one existing electrode position, and superimposable on at least 40% of at least one existing electrode position by rotation of the array around the centroid; and a hydrocolloid material disposed in the at least one void space.

Abstract: The present invention relates to a Transcranial Magnetic Stimulation (TMS) system comprising a TMS apparatus for delivery of TMS to a subject and an input device physically disconnected from the TMS apparatus. The TMS system is designed to enable use in a home environment without the requirement of an in person medical practitioner.

Abstract: An object of the present invention is to provide a phototherapy device with which a light irradiation region can be accurately positioned on a treatment site. The phototherapy device according to an embodiment of the present disclosure includes a barrel, a light source which is installed inside the barrel and which emits light, a plurality of imaging units for imaging a marking arranged on a body, a deviation amount calculation unit for calculating a deviation amount between a plurality of images of the marking included in a plurality of images captured by the plurality of imaging units, an image combining unit for combining the plurality of images of the marking based on the calculated deviation amount, a target position determination unit for determining a position of a target in the combined image corresponding to an irradiation region of light from the light source, and a display unit for overlaying and displaying an image of a target on the combined image of the marking.

Abstract: A light delivery device for delivering light therapy includes a light source configured to emit light, one or more first piercing members extending from a distal surface of the light delivery device, the one or more first piercing members being light-transmissive and being configured to be inserted into a subdermal or intradermal portion of the skin of the subject as the distal surface is placed against the skin of the subject. The one or more first piercing members are configured to, when inserted into the skin of the subject, deliver the light to the subdermal or intradermal portion of the skin of the subject.

Abstract: An ophthalmic device for use on an anterior surface of an eye including a treatment chamber defined at least in part by an anterior ring, a posterior ring, and an upper surface connecting the anterior ring and the posterior ring, the treatment chamber configured to transmit a force against the anterior surface of the eye; and a fixation chamber configured to be in fluid communication with a vacuum source and in fluid communication with the anterior surface of the eye. Related devices, systems, and methods are provided.