Patents Issued in January 11, 2024
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Publication number: 20240010930Abstract: A system for crude oil desalting and dehydration includes a separation vessel defining a cavity extending along a central axis having a substantially-vertical orientation. The separation vessel comprises a first distributor configured to distribute a mixture within the cavity of the separation vessel, and a second distributor configured to distribute a wash fluid within the cavity of the separation vessel. The mixture comprises crude oil, water, dissolved salts, free salts, or combinations thereof, and the wash fluid comprises an aqueous fluid. The first distributor is disposed within the cavity below the second distributor, and an interface level controller is configured to detect an interface between an oil phase and an aqueous phase and to maintain the interface within a predetermined range within the cavity.Type: ApplicationFiled: August 2, 2023Publication date: January 11, 2024Inventors: Terrance John Larry TROFIMUK, Fiona MCGREGOR, Michael THOMAS
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Publication number: 20240010931Abstract: Method for treating a partially desulphurised sulphur-containing hydrocarbon feedstock from a preliminary hydrodesulphurisation step in the presence of a catalyst comprising an active phase comprising a group VII metal and a mesoporous and macroporous alumina support comprising a bimodal distribution of mesopores, wherein: -the volume of mesopores having a diameter greater than or equal to 2 nm and less than 18 nm is between 10 and 30% by volume of the total pore volume of the support; -the volume of mesopores having a diameter greater than or equal to 18 nm and less than 50 nm is between 30 and 50% by volume of the total pore volume of the support; -the volume of macropores having a diameter greater than or equal to 50 nm and less than 8000 nm is between 30 and 50% by volume of the total pore volume of the support.Type: ApplicationFiled: November 18, 2021Publication date: January 11, 2024Applicant: IFP Energies nouvellesInventors: Philibert LEFLAIVE, Etienne GIRARD, Antoine FECANT
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Publication number: 20240010932Abstract: The invention relates to a method for capturing organometallic impurities in a gasoline-type hydrocarbon feedstock containing sulfur compounds and olefins, wherein said feedstock is brought into contact with hydrogen and a capture mass comprising a nickel-based active phase, and a mesoporous and macroporous alumina substrate having a bimodal distribution of mesopores and wherein: —the volume of mesopores having a diameter greater than or equal to 2 nm and less than 18 nm corresponds to between 10 and 30% by volume of the total pore volume of said substrate; —the volume of mesopores with a diameter greater than or equal to 18 nm and less than 50 mm corresponds to between 30 and 50% by volume of the total pore volume of said substrate; the volume of macropores having a diameter greater than or equal to 50 nm and less than 8000 mm corresponds to between 30 and 50% by volume of the total pore volume of said substrate.Type: ApplicationFiled: November 18, 2021Publication date: January 11, 2024Applicant: IFP Energies nouvellesInventors: Elodie DEVERS, Etienne GIRARD, Philibert LEFLAIVE
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Publication number: 20240010933Abstract: The invention relates to a method for hydrodesulfurization of a sulfur-containing olefinic gasoline cut wherein said gasoline cut, hydrogen and a catalyst comprising an alumina support obtained by dehydration of an aluminum hydroxide or oxyhydroxide at a temperature of between 400° C. and 1200° C. and for a time of between 0.1 seconds and 5 seconds, at least one metal from group VIB, at least one metal from group VIII, and phosphorus are brought into contact, the molar ratio between the phosphorus and the metal from group VIB being between and 0.35.Type: ApplicationFiled: November 18, 2021Publication date: January 11, 2024Applicant: IFP Energies nouvellesInventors: Philibert LEFLAIVE, Etienne GIRARD, Antoine FECANT, Charlie BLONS
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Publication number: 20240010934Abstract: A method for upgrading mixed pyrolysis oil may include contacting the mixed pyrolysis oil with hydrogen in the presence of a mixed metal oxide catalyst at reaction conditions to produce a reaction effluent including light aromatic compounds. The mixed pyrolysis oil includes multi-ring aromatic compounds and is formed from light pyrolysis oil and heavy pyrolysis oil at a ratio of 10:90 to 40:60 with light pyrolysis oil representing a bottom stream of a gas steam cracker and heavy pyrolysis oil representing a bottom stream of a naphtha steam cracker. The mixed metal oxide catalyst includes a plurality of catalyst particles with each catalyst particles including a plurality of metal oxides. An associated system for upgrading mixed pyrolysis oil may include a pyrolysis upgrading unit housing the mixed metal oxide catalyst and a separation unit operable to separate used mixed metal oxide catalyst from the reaction effluent.Type: ApplicationFiled: July 6, 2023Publication date: January 11, 2024Applicants: Saudi Arabian Oil Company, SABIC Global Technologies B.V.Inventors: Miao Sun, Sohel K. Shaikh, Wojciech Andrzej Supronowicz, Chandrasekar Subramani, Eman Z. Albaher
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Publication number: 20240010935Abstract: A composition of matter is provided comprising hierarchically ordered crystalline microporous material having well-defined long-range mesoporous ordering of cubic symmetry. The composition possesses mesopores having walls of crystalline microporous material and a mass of mesostructure between mesopores of crystalline microporous material. Long-range ordering is defined by presence of secondary peaks in an X-ray diffraction (XRD) pattern and/or cubic symmetry observable by microscopy.Type: ApplicationFiled: July 5, 2022Publication date: January 11, 2024Inventors: Rajesh Kumar PARSAPUR, Robert P. HODGKINS, Omer Refa KOSEOGLU, Kuo-Wei HUANG, Anissa Bendjeriou SEDJERARI
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Publication number: 20240010936Abstract: The present disclosure refers to systems and methods for efficiently converting a C1-C3 alkane such as natural gas to a liquid C2-C10 product and hydrogen. Generally, the process comprises flowing the C1-C3 alkane through a plurality of tubes within a vessel wherein the tubes house a catalyst for converting the C1-C3 alkane to the liquid C2-C10 product and hydrogen. The C1-C3 alkane is heated under suitable conditions to produce the liquid C2-C10 product and hydrogen. Advantageously, the C1-C3 alkane is heated by burning a fuel outside the tubes in fuel burning nozzles configured to transfer heat from the burning through the tubes.Type: ApplicationFiled: September 26, 2023Publication date: January 11, 2024Inventors: Lin LI, Huping LUO, Xiaoying OUYANG, Alexander KUPERMAN
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Publication number: 20240010937Abstract: A solvent stripping process has been developed for separating the pyrolysis oil in an extracted phase feed stream from an organic solvent used for extraction. The process involves using a stripping solvent to strip the organic solvent from the pyrolysis oil in a stripping column. The stripping column bottom stream comprising the pyrolysis oil and part of the stripping solvent can be separated into a vapor stream comprising the stripping solvent and a liquid stream comprising the pyrolysis and a portion of the stripping solvent. The stripping column overhead stream comprising the stripping solvent and the organic solvent can be separated in a recovery column into a recovery column overhead stream comprising the stripping solvent and a recovery column bottom stream comprising the organic solvent.Type: ApplicationFiled: April 6, 2023Publication date: January 11, 2024Inventors: Anton N. Mlinar, Stanley J. Frey, Geoffrey W. Fichtl, Matthew C. Cole, Charles P. Luebke, Joe R. Haas
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Publication number: 20240010938Abstract: A production plant and a method for production of a synthetic gasoline product from a synthetic hydrocarbon mixture produced by post-treatment of a synthetic gasoline product including less than a specified concentration of olefins, such as 6 vol % or 11 vol % from a first synthetic hydrocarbon mixture produced from a mixture of reactive oxygenates, the first synthetic hydrocarbon mixture having T90 of less than 140° C. and including at least the specified concentration of olefins and a second synthetic hydrocarbon mixture, produced from a mixture of reactive oxygenates, the second synthetic hydrocarbon mixture having T90 of more than 150° C., the method including: a. directing the second synthetic hydrocarbon mixture to contact a material catalytically active in hydrocracking under effective hydrocracking conditions, to provide a hydrocracked second synthetic hydrocarbon mixture, b.Type: ApplicationFiled: December 1, 2021Publication date: January 11, 2024Applicant: TOPSOE A/SInventors: Angelica HIDALGO VIVAS, Nghia Pham PHU, Rickard VANNBY, Ole Frej ALKILDE, Thoa Thi Minh NGUYEN
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Publication number: 20240010939Abstract: Provided herein is a method for producing a hydrocarbon fluid from waste plastic feedstock, comprising (a) providing a first hydrocarbon feed stream, wherein at least 50 wt % off said first hydrocarbon feed stream is obtained from pyrolysis of plastic waste; (b) removing contaminants from said first hydrocarbon feed stream using a washing step with a polar solvent and/or contacting the stream with one or more adsorbents; thereby obtaining a first hydrocarbon fluid; and (c) hydrogenation of olefins and diolefins in said first hydrocarbon fluid; thereby obtaining a hydroprocessed hydrocarbon fluid containing less than 0.1 wt % olefins; a total amount of Nmetals selected from mercury, lead, and iron below 5 wppm; less than 5 wppm of chlorine and fluorine; and less than 5 wppm of sulfur.Type: ApplicationFiled: October 21, 2021Publication date: January 11, 2024Inventors: Daniel Bien, Cody M. Diaz, Hans K. Goris, Blaise H. Bridier, Chunzhao Li
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Publication number: 20240010940Abstract: Provided is a continuous process for converting waste plastic into recycle for chemical production. The process comprises selecting waste plastics containing polyethylene and/or polypropylene and preparing a stable blend of a bio feedstock and the selected plastic. The amount of plastic in the blend comprises no more than 20 wt. % of the blend. The blend is passed to a conversion unit. Useful chemicals are recovered, including C3 and C4 olefins and aromatics.Type: ApplicationFiled: July 10, 2023Publication date: January 11, 2024Applicant: Chevron U.S.A. Inc.Inventors: Tengfei LIU, Joel E. SCHMIDT, Hye-Kyung C. TIMKEN
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Method and installation for gasification of heterogenic mixtures of organic substances and compounds
Publication number: 20240010941Abstract: The present invention relates to a process and an installation for the continuous flow of gasification of heterogeneous mixtures of organic substances and compounds such as biomass waste, forestry, municipal solid and liquid waste, sludge from sewage treatment plants and other similar waste. Presentation Of The Invention: The process according to the invention has the following steps: a) the organic raw material in heterogeneous mixture is introduced into the pyrolysis reactor (2) where it is gradually heated, by forced convection and thermal radiation, to a temperature of 900 . . . 1000° C., being kept in contact with metal surfaces that transport thermal energy through conduction from the exothermic area of the gasification reactor. The metal surfaces are placed in fixed positions, different so that the contact surface changes after 5 . . . 20 cm traversed by the flow of organic raw material, each group of metal slats forming 2 . . .Type: ApplicationFiled: April 4, 2021Publication date: January 11, 2024Inventors: Vlad Francu, Marius-Andrei Francu, Bogdan-Sabin Francu, Costin-Marian Francu -
Publication number: 20240010942Abstract: This invention relates to oil-in-water (water continuous) emulsions that can be used as fuels, in particular oil-in-water emulsions comprising glycerol. The invention also relates to a process for their preparation and to fuel compositions comprising such emulsions.Type: ApplicationFiled: December 3, 2021Publication date: January 11, 2024Inventors: Jason Victor MILES, Patrick BRUNELLE, Dennis SELSE
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Publication number: 20240010943Abstract: The present invention provides a lubricating oil composition comprising: (A) a lubricant base oil including at least one type selected from mineral oil, PAO, and GTL (gas-to-liquid) base oils; (B) a compound having a structure obtained by independently subjecting propylene oxide to addition polymerization with an alcohol or a structure obtained by subjecting a combination of propylene oxide with ethylene oxide and/or butylene oxide to addition polymerization with an alcohol, and being configured so that polyalkylene glycol (PAG) with an oxygen/carbon weight ratio of 0.35 or more and less than 0.45 and/or one or both terminal hydroxyl groups in the polyalkylene glycol (PAG) are blocked; and (C) a fatty acid ester having an oxygen/carbon weight ratio of 0.05 to 0.35.Type: ApplicationFiled: November 30, 2021Publication date: January 11, 2024Inventors: Kengo SUZUKI, Kunitoshi ABE
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Publication number: 20240010944Abstract: A method for hydrotreating and recycling waste lubricating oil, the method comprising the two steps of slurry bed pre-hydrotreatment and deep hydrotreatment, specifically as follows: mechanical impurities are removed from waste lubricating oil, and then the oil is subjected to flash distillation to separate free water and a portion of light hydrocarbons; a bottom product of the flash distillation column is mixed with hydrogen and a self-sulfurizing oil-soluble transition metal catalyst, and then enters a slurry bed reactor for pre-hydrotreatment; a liquid product obtained by performing separation on a reaction effluent is subjected to hydrocyclone separation and solvent washing to remove solid residue, and then a pre-treated lubricating oil component is obtained; said component is mixed with hydrogen and then enters a hydrofining reactor, an isomerization-dewaxing reactor, and a supplementary refining reactor, connected in series, for hydrotreatment; and the reaction products are separated to obtain high-qualType: ApplicationFiled: January 10, 2022Publication date: January 11, 2024Inventors: Bin LIU, Yongming CHAI, Chenguang LIU, Yuan PAN, Yichuan LI, Kongyuan ZHANG, Yunqi LIU
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Publication number: 20240010945Abstract: The present invention relates to liquid aqueous detergent compositions comprising a surfactant system comprising a primary surfactant being anionic surfactant, a secondary surfactant being amphoteric surfactant and polyethylene oxide whilst the surfactant system is free of alkylbenzene sulphonates and derivatives thereof. The invention further relates to a method of cleaning a stainless-steel hard surface using the composition of the invention, as well as the use thereof.Type: ApplicationFiled: December 2, 2021Publication date: January 11, 2024Applicant: Conopco Inc., d/b/a UNILEVERInventors: Ivana TROMBETTA, Serena PEZZIA, Luca PRETALI, Lorena GALLUZZI
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Publication number: 20240010946Abstract: An ancillary laundry composition comprising: hydrolysed protein, free perfume and 0 to 2 wt. % anionic and/or cationic surfactant.Type: ApplicationFiled: August 30, 2021Publication date: January 11, 2024Applicant: Conopco, Inc., d/b/a UNILEVERInventor: Karl BURGESS
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Publication number: 20240010947Abstract: The present invention relates to liquid aqueous detergent compositions comprising a surfactant system comprising a primary surfactant being anionic surfactant and a secondary surfactant being amphoteric surfactant whilst the surfactant system is free of alkylbenzene sulphonates and derivatives thereof. The invention further relates to a method of cleaning a stainless-steel hard surface using the composition of the invention, as well as the use thereof.Type: ApplicationFiled: November 18, 2021Publication date: January 11, 2024Applicant: Conopco Inc., d/b/a UNILEVERInventors: Maheshwara Shiva NAIK, Jiji Paul KOTTUKAPALLY
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Publication number: 20240010948Abstract: A fabric conditioner composition comprising; a) Ester linked quaternary ammonium compounds; and b) 0.1 to 30 wt. % perfume materials; wherein the ester linked quaternary 5 ammonium compounds comprise carbon chains derived from fatty acids; the fatty acids have an iodine value of 0 to 75; and the fatty acids comprise non-edible rice bran fatty acids.Type: ApplicationFiled: December 22, 2021Publication date: January 11, 2024Applicant: Conopco, Inc., d/b/a UNILEVERInventors: John Francis HUBBARD, Wan HUNG
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Publication number: 20240010949Abstract: Provided among other things is a cleaning composition comprising: a carrier fluid; and Minute Fibrils suspended in the carrier fluid, wherein the composition is protein cleaning effective.Type: ApplicationFiled: May 2, 2023Publication date: January 11, 2024Inventors: Mohamed Emam Labib, Stanislav S. Dukhin, Yacoob Tabani, Ching-Yue Lai, James L. Manganaro, Peter Materna, Jeffrey C. Robertson
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Publication number: 20240010950Abstract: A detergent composition comprising: (a) ethylenediamine-N,N?-disuccinic acid (EDDS) or salt thereof; (b) an aminocarboxylate selected from methylglycine diacetic acid (MGDA) or salt thereof and gluconic acid diacetic acid (GLDA) or salt thereof; and (c) from 3 to 80% (by weight based on the total weight of the composition) of one or more detersive surfactants.Type: ApplicationFiled: November 30, 2021Publication date: January 11, 2024Applicant: Conopco Inc., d/b/a UNILEVERInventor: Katherine Mary THOMPSON
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Publication number: 20240010951Abstract: A detergent composition for the non-oxidative cleaning of substrate stains, the composition comprising: (b) gluconic acid or salt thereof; (b) an aminocarboxylate; and (c) from 3 to 80% (by weight based on the total weight of the composition) of one or more detersive surfactants.Type: ApplicationFiled: November 30, 2021Publication date: January 11, 2024Applicant: Conopco Inc., d/b/a UNILEVERInventor: Katherine Mary THOMPSON
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Publication number: 20240010952Abstract: This disclosure relates to compositions for cleaning post etching residues on a semiconductor substrate, as well as related cleaning methods.Type: ApplicationFiled: April 26, 2023Publication date: January 11, 2024Inventors: Jieying Jiao, Thomas Dory
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Publication number: 20240010953Abstract: Disclosed are aqueous compositions of selected anionic polyesters and of selected nonionic polyesters. These compositions are characterized by good storage stability and low viscosity and can be used in detergents and cleaning agents to improve soil release.Type: ApplicationFiled: September 30, 2021Publication date: January 11, 2024Inventors: Daniel Könning, Roman Morschhäuser, Judith Preuschen, Paul Kaufmann, Niklas Diekhans, Said Kchirid, Stefan Riegelbeck, Bastian Viel
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Publication number: 20240010954Abstract: A laundry detergent composition containing a graft copolymer and a benefit agent.Type: ApplicationFiled: May 23, 2023Publication date: January 11, 2024Inventors: Ming TANG, Renae Dianna FOSSUM, Kejing DU, Xiaoyi REN, Zhen ZHONG, Haiyan SONG, Karen Hussong STRADER
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Publication number: 20240010955Abstract: The present invention relates to compositions such as cleaning compositions comprising enzymes. The invention further relates to the use of the compositions comprising such enzymes in cleaning processes.Type: ApplicationFiled: July 6, 2023Publication date: January 11, 2024Applicant: Novozymes A/SInventors: Rebecca Munk Vejborg, Dorotea Raventos Segura, Jesper Salomon, Johanne M. Jensen, Rune Nygaard Monrad, Anne Vindum Due, Martin Gudmand
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Publication number: 20240010956Abstract: The present invention relates to a method of washing textile articles that can be carried out, for example, in a continuous batch tunnel washer. Embodiments of the present method can include treating the textile with an aqueous composition including cleaning agent and halogen-containing bleaching agent for a time sufficient to remove soil from the textile and contacting the halogen-treated textile with an aqueous composition including a peroxycarboxylic acid. The concentration of halogen after the sufficient time can be at a level that does not result in adverse interaction between the halogen-containing bleaching agent and the peroxycarboxylic acid. Embodiments of the present method can clean textiles with the results of more effective stain removal and less waste through destruction of the textile article. Further, the present invention can clean a textile contacted soiled by a composition including chlorhexidine gluconate without resulting staining of the textile, which staining could have been permanent.Type: ApplicationFiled: August 14, 2023Publication date: January 11, 2024Inventors: Russell Shawn Berman, Max Donald Harper, Joel Monroe Madenwald, Carl Henry Mattson
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Publication number: 20240010957Abstract: An automotive surface is cleaned by applying an effective amount of a cleaning composition comprising a) at least one hydrocarbon solvent in an amount from about 3 weight percent to about 20 weight percent of the composition, b) at least one thickener/rheology modifier in an amount from about 0.01 weight percent to about 3 weight percent, c) at least one silicone fluid has a viscosity ranging from about 500 to about 20,000 centistokes at 25° C., present in an amount from about 0.1 weight percent to about 3 weight percent, d) at least one wetting agent in an amount from about 0.001 to about 2%, e) at least one hydrophobic additive in an amount from about 0.1 to about 3%, and f) water in an amount from about 60 weight percent to about 85 weight percent to the automotive surface with an application implement.Type: ApplicationFiled: May 19, 2023Publication date: January 11, 2024Applicant: Energizer Auto, Inc.Inventors: Rajeev Menon, Ashot K. Serobian, Cindy Luna-Zaragoza
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Publication number: 20240010958Abstract: The present invention relates to a washing agent tablet having a printable phase made of a compressed particulate premixture, wherein the particulate premixture has a particle size distribution in which at least 60 wt. % of the particles have a particle size of between 100 ?m and 900 ?m, and at least 90% of the surface of the printable phase outside the printed region has a degree of whiteness which is defined by L*max, a*max, and b*max.Type: ApplicationFiled: September 22, 2023Publication date: January 11, 2024Applicant: Henkel AG & Co. KGaAInventors: Matthias Sunder, Niklas Matzeit, Marouane Jaafour, Mareile Job, Till Frey
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Publication number: 20240010959Abstract: A process for the production of beer. More particularly, the invention relates to a step of mashing for the beer production process. In particularly, the present invention relates firstly to the mashing of a first portion of the milled malt to be fed to a mashing step and then, to the mashing the same again with a second portion. In said mashing process, the ratio of the first portion of the milled malt to the total milled malt is at most 50% by weight. In another aspect, the invention relates to the use of mashing method according to the invention for the production of beer. In a further aspect, the invention relates to beer obtained by the mashing method.Type: ApplicationFiled: June 16, 2021Publication date: January 11, 2024Inventors: Serkan Akin, Koray Anar
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Publication number: 20240010960Abstract: A method for producing tissue constructs comprising two or more distinct regions, each of which comprises a different cell population or lineage is described. The method involves providing a support substrate or substrate assembly comprising two or more physically distinct regions, wherein the two or more physically distinct regions of the support substrate or substrate assembly are different from each other; and depositing/positioning one or more cells on the support substrate or substrate assembly. The cells can form a continuous monolayer with at least two zones, e.g., a proliferative zone and a nonproliferative zone, that can act as in vitro intestinal models. The models are two-dimensional, thus facilitating rapid and facile imaging. Systems comprising the tissue constructs and methods of using the constructs to study the effects of pharmaceuticals, nutraceuticals, and metabolites on intestinal cells are also described.Type: ApplicationFiled: September 22, 2023Publication date: January 11, 2024Inventors: Nancy L. Allbritton, Yuli Wang, Raehyun Kim
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Publication number: 20240010961Abstract: In one embodiment, the present disclosure provides a tissue culture well insert for use with a multi-wells tissue culture plate. The cylindrical well insert is configured to be inserted into the tissue culture wells, wherein the well insert comprises a carrier or platform section on which liver cells or other cells are deposited, and the carrier or platform section is positioned in the tissue culture wells so as to be suspended off the bottom of the tissue culture wells. The well insert is useful for co-culturing multiple cell types to create in vitro biological systems. One specific application is high-throughput anti-tumor drug screening in which the liver cells or other cells carried by the carrier or platform section of the insert are co-cultured with tumor organoids deposited or bioprinted to the bottom of the tissue culture well.Type: ApplicationFiled: December 7, 2021Publication date: January 11, 2024Applicant: The Regents of the University of CaliforniaInventors: Alice SORAGNI, Peyton John TEBON
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Publication number: 20240010962Abstract: A microfluidic cell culture device for cell cultivation includes two or more media reservoirs, a first microfluidic chamber having a non-planar surface, a second microfluidic chamber being a pressure chamber and a flexible non-porous membrane that separates the first microfluidic chamber and the second microfluidic chamber. The flexible non-porous membrane is opposite to the non-planar surface of the first microfluidic chamber. One or more microfluidic channels connect the first microfluidic chamber to the two or more media reservoirs. Disclosed also is a method of cell cultivation using the aforementioned microfluidic cell culture device.Type: ApplicationFiled: September 6, 2022Publication date: January 11, 2024Applicant: Finnadvance OyInventors: Prateek SINGH, Hoang NGUYEN, Tuomas NURMI
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Publication number: 20240010963Abstract: Provided are a cell culture device for producing a cell sheet to be used in regenerative medicine and drug discovery research, and a kit for producing a cell sheet. Specifically, a cell detachment inhibition region having cell adhesive force stronger than that of a stimulus-responsive region regardless of the presence or absence of stimulation, and inhibiting cell detachment is directly provided over the entire circumference of a cell culture surface, and the stimulus-responsive region having adhesiveness to cells, which is varied due to an external stimulus, is arranged inside the cell detachment inhibition region, thereby forming a culture device for prevention of cell detachment due to mechanical stimulation such as medium exchange. Moreover, with a support for harvesting cell sheet to be used for the harvest of a cell sheet having given features, the cell sheet can be easily harvested.Type: ApplicationFiled: December 1, 2021Publication date: January 11, 2024Inventors: Daishi Suga, Yuji Ueno, Yuzo Kasuya
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Publication number: 20240010964Abstract: Improved biolistic bombardment is observable when using a modification to a double-barrel device. One such modification is a custom attachment that can be retrofit to a standard helium-based gene gun. The custom attachment facilitates DNA and protein delivery. The attachment confines the flow of particles in a barrel similar to the choke on a shotgun barrel.Type: ApplicationFiled: July 7, 2023Publication date: January 11, 2024Inventors: Shan Jiang, Kyle Miller, Connor Phelps Thorpe, Alan Eggenberger, Kan Wang
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Publication number: 20240010965Abstract: The present application relates to biotechnological fluid treating, such as biopharmaceutical liquids in order to obtain products such as monoclonal antibodies, vaccines or recombinant proteins, and particularly to a system for treating a biotechnical fluid, having a bioprocess machine and at least one bioprocess machine helper, configured to connect to each other and each comprising a controller, in turn comprising a machine-to-machine communication tool configured for connecting to a network.Type: ApplicationFiled: August 19, 2021Publication date: January 11, 2024Applicant: MERCK PATENT GMBHInventors: Rene REINBIGLER, Denis DUBRET, Steven MILLER
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Publication number: 20240010966Abstract: An apparatus for magnetic cell isolation includes a base, a stopcock manifold interface located on the base and configured to receive a stopcock manifold of a cell processing kit, a magnetic field generator located within the base, and a slot formed in the base, the slot configured to removably receive a magnetic cell isolation holder. The magnetic field generator is movable into and out of engagement with the magnetic cell isolation holder.Type: ApplicationFiled: December 14, 2021Publication date: January 11, 2024Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: YORICK HEIMBERG, OLIVIER MARTI, THOMAS MERMOD, BENOIT DUBATH, JULIEN CAMISANI
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Publication number: 20240010967Abstract: An apparatus for isolating stems cells from extracted mammalian tissue comprising: a portable hollow casing having fixed dimensions and a sized internal spatial volume; a filter housed and contained within said sized internal spatial volume, wherein said filter captures particles in said extracted mammalian tissue having a diameter of about 5 to 10 microns or more and allows particles in said extracted mammalian tissue having a diameter of less than about 5 to 10 microns to pass through; a first channel to which a container holding said extracted mammalian tissue can attach, and through which said extracted mammalian tissue is input into the hollow casing; wherein a stem cell collection chamber can attach to said first channel, and the particles having a diameter of about 5 to 10 microns or more are output from the hollow casing through said first channel and collected in the stem cell collection chamber; and a second channel to which a remnant collection chamber can attach, and through which the particlesType: ApplicationFiled: September 22, 2023Publication date: January 11, 2024Inventor: Riam SHAMMAA
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Publication number: 20240010968Abstract: This invention concerns a method for preparing a bacterial supernatant comprising culturing a cell of Pseudomonas environmental strain PF-11; and recovering the supernatant. This invention also concerns a method for reducing the amount of a biofilm on a surface, reducing adhesion of at least one organism to a surface, or reducing microfouling or macrofouling on a surface comprising contacting the surface with a supernatant, supernatant fraction, modified supernatant or modified supernatant fraction of Pseudomonas strain PF-11; or a composition comprising a supernatant, supernatant fraction, modified supernatant or modified supernatant fraction of Pseudomonas strain PF-11, and one or more acceptable carriers.Type: ApplicationFiled: September 20, 2023Publication date: January 11, 2024Applicant: BioMimetx LDA.Inventors: Gonçalo Costa, Patrick Freire, Romana Santos, Ana Cristina Silva, Inês Guinote
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Publication number: 20240010969Abstract: Provided is a recombinant yeast expressing germacrene A synthetase or a fusion protein thereof, wherein the fusion protein is germacrene A synthetase and farnesyl pyrophosphate synthase. The recombinant yeast improves the yield of germacrene A, and is suitable for the industrialized production of ?-elemene and/or germacrene A.Type: ApplicationFiled: August 25, 2023Publication date: January 11, 2024Inventors: Xueli Zhang, Luqi Huang, Zhubo Dai, Dong Wang, Lili Zhang, Juan Guo, Yi Liu
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Publication number: 20240010970Abstract: Provided herein are antimicrobial biosensors for skin for treating Staphylococcus aureus Type I, Type II, Type III, and/or Type IV infection. In some embodiments, the antimicrobial biosensors are expressed in Staphylococcus epidermidis cells.Type: ApplicationFiled: October 20, 2021Publication date: January 11, 2024Applicant: The Jackson LaboratoryInventor: Julia Oh
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Publication number: 20240010971Abstract: Disclosed herein are spore compositions and methods of producing such compositions. Additionally disclosed herein are plant protection products benefiting from such spore compositions and methods of using such compositions for the benefit of plants, for the reduction of pathogen emissions to nearby areas and for the benefit of animals or humans. Further disclosed herein are methods of efficient fermentation.Type: ApplicationFiled: December 10, 2021Publication date: January 11, 2024Inventors: Tobias MAY, Reinhard STIERL, Hsuan CHANG, Daniel Christoph HEINRICH, Evangelina Priya HAAS, Andrea HEROLD
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Publication number: 20240010972Abstract: A packed-bed cell culture matrix and bioreactor system for culturing cells is provided. The system includes a cell culture vessel having an inlet, an outlet, and an interior reservoir fluidly connected to and disposed between the inlet and the outlet. A cell culture matrix is disposed in the reservoir, the cell culture matrix having a structurally defined substrate with a substrate material defining a plurality of pores, and the substrate material is for adhering cells thereto. A permeability zone is located in a portion of the cell culture matrix, the at least one permeability zone having a higher permeability than a standard permeability of the cell culture matrix outside of the permeability zone. The permeability zone has an opening in the substrate, where the opening is larger than a diameter of any of the plurality of pores.Type: ApplicationFiled: November 18, 2021Publication date: January 11, 2024Inventor: Vasiliy Nikolaevich Goral
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Publication number: 20240010973Abstract: Methods of generating a synthetic embryo are provided. Accordingly, there is provided a method of generating a synthetic embryo comprising inducing expression of a factor that induces differentiation to trophectoderm cells in a subpopulation of naïve pluripotent stem cells (PSCs) to obtain a trophectoderm primed cells; inducing expression of a factor that induces differentiation to extra embryonic primitive endodermal cells in a second subpopulation of naïve PSCs to obtain extra embryonic primitive endodermal primed cells; and mixing said trophectoderm primed cells and said extra embryonic primitive endodermal primed cells with naïve PSCs under conditions that allow formation of aggregated cells. Also provided are articles of manufactures, mixtures and aggregates of cells and methods of using same.Type: ApplicationFiled: July 27, 2023Publication date: January 11, 2024Applicant: Yeda Research and Development Co. Ltd.Inventors: Yaqub HANNA, Sergey VIUKOV, Emilie WILDSCHUTZ, Noa NOVERSHTERN, Carine JOUBRAN, Segev NAVEH TASSA, Alejandro CASTREJON AGUILERA, Bernardo OLDAK, Shadi TARAZI, Francesco RONCATO
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Publication number: 20240010974Abstract: An object of the present invention is to provide a method of producing a cell population comprising mesenchymal stem cells, comprising efficiently isolating a cell population comprising mesenchymal stem cells at high purity from an amnion. Provided is a method of producing a cell population comprising amnion-derived mesenchymal stem cells, comprising (1) storing an amnion in a medium for 4 hours or longer at ?1° C. or higher and 25° C. or lower, followed by (2) isolating the amnion from the medium and treating the amnion with an enzyme; and (3) culturing a cell fraction comprising mesenchymal stem cells after the treatment with the enzyme.Type: ApplicationFiled: September 25, 2023Publication date: January 11, 2024Applicant: KANEKA CORPORATIONInventors: Chiho KOBAYASHI, Nobuhiko SATO, Rio MASAYASU
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Publication number: 20240010975Abstract: The present application provides methods, cell culture media and combinations thereof for generating neural progenitor cells (NPCs), particularly human neural progenitor cells (hNPCs), from either embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs), wherein the NPCs are particularly suitable for pre-clinical and clinical use.Type: ApplicationFiled: May 10, 2021Publication date: January 11, 2024Inventors: Jing FAN, Anxin WANG, Fang REN, Qianyun LIU, Tan ZOU
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Publication number: 20240010976Abstract: Compositions and methods for stimulating ?? T cell expansion and cytotoxicity are described. Therapeutic compositions and methods using expanded and stimulated ?? T cells are described.Type: ApplicationFiled: August 12, 2021Publication date: January 11, 2024Inventors: Alicja COPIK, Jeremiah OYER, Thomas DIEFFENTHALLER, Griff PARKS
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Publication number: 20240010977Abstract: This disclosure relates to methods for enhancing the therapeutic efficacy of isolated cells for use in cell therapies such as adoptive cell transfer therapies by insertion of an under-expressed miRNA that is beneficial for therapeutic efficacy of cell therapies into the actively expressed locus of a gene, either protein coding or non-coding, that hampers therapeutic efficacy of cell therapies by this disrupting expression of the latter while inducing expression of the former.Type: ApplicationFiled: June 1, 2023Publication date: January 11, 2024Applicant: LEPTON PHARMACEUTICALS LTDInventors: Daniel Zurr, Hagar Kalinski, Elena Feinstein
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Publication number: 20240010978Abstract: This invention provides a method for preparing dendritic cells from monocytes using a platelet lysate. This invention also provides a method for preparing cytotoxic dendritic cells from monocytes comprising performing non-adhesion culture of monocytes separated from the peripheral blood using a serum-free medium containing a human platelet lysate (HPL), GM-CSF, and PEGylated interferon ? and performing further non-adhesion culture with the addition of prostaglandin E2 and OK432.Type: ApplicationFiled: November 4, 2021Publication date: January 11, 2024Applicants: ALP REGENERATIVE MEDICINE INSTITUTE, INC., KANAZAWA MEDICAL UNIVERSITYInventors: Shigetaka SHIMODAIRA, Terutsugu KOYA, Takuya SAKAMOTO, Misa TOGI
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Publication number: 20240010979Abstract: Provided herein are populations of modified NK-92 cells, compositions and kits comprising the cells, and methods of making and using the populations of cells.Type: ApplicationFiled: July 18, 2023Publication date: January 11, 2024Inventors: Hans Klingemann, Laurent Boissel, Patrick Soon-Shiong