Abstract: The present invention relates to anti-OPG antibodies, and to methods of treatment, uses and pharmaceutical compositions comprising such antibodies, for example in the treatment and prevention of PAH.

Abstract: Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for Fc?RIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.

Abstract: The present invention relates to a high affinity, VNAR polypeptide cross reactive with primate transferrin receptors (“TfR”). This TfR-specific VNAR polypeptide was obtained by screening semisynthetic VNAR phage display libraries against recombinant human TfR-1. The VNAR polypeptides of the invention can be used alone or as a component in conjugates that target the transferrin/transferrin receptor transport system. The invention further includes use of this VNAR, its conjugates and other derivatives in diagnostic and therapeutic methods, e.g., to diagnose, treat and/or prevent a pathological condition, disorder or disease in which it is beneficial to deliver a heterologous biomolecule across the blood brain barrier or other membrane systems. This TfR-specific VNAR polypeptide can also be used to target other biological barriers such the intestines, the placenta or aberrant cells overexpressing TfR-1, for therapeutic benefit in treatment of certain cancer cells and tumors of various tissue types.

Abstract: The present invention relates to Fc variants having decreased affinity for Fc?RIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.

Abstract: Provided is an isolated antigen-binding protein, capable of binding to CD73. The isolated antigen-binding protein contains HCDR3, and the HCDR3 comprises an amino acid sequences as shown in SEQ ID No.:3. Also provided are a preparation method for the antigen-binding protein, and an application of the antigen-binding protein.

Abstract: This invention relates to inhibition of the N-cadherin signaling using a humanized anti-N-cadherin antibody. In one embodiment, the invention relates to methods of treating an N-cadherin-mediated disease or N-cadherin-mediated disorder in a subject by contacting the subject with an anti-N-cadherin antibody.

Abstract: The invention provides a method for inhibiting an intracellular target in a cell with a bispecific antibody comprising contacting the cell with a bispecific antibody having a first Fv fragment with a cell-penetrating determinant and a second Fv fragment with an intracellular target-binding determinant under suitable conditions so that the first Fv fragment causes the bispecific antibody to enter the cell and the second Fv fragment binds the intracellular target in the cell and thereby inhibiting the intracellular target.

Abstract: This invention provides a method that allows selection of antibodies against cells (e.g., tumor cells) in situ using laser capture microdissection. By restricting antibody selection to binders of internalizing epitopes, a panel of phage antibodies was generated that targets clinically represented prostate cancer antigens.

Abstract: Provided are an anti-HER3 antibody and an anti-HER3 antibody-drug conjugate and a medical use thereof, specifically, the anti-HER3 antibody, and the anti-HER3 antibody-drug conjugate as represented by general formula (Pc-L-Y-D), wherein Pc is an anti-HER3 antibody, and L, Y and n are as defined in the description.

Abstract: The invention relates to the field of therapeutic (human) antibodies for the treatment of a subject with an ERBB3 mutation positive cancer. More in particular it relates to treating cancers comprising an ERBB3 mutation that drives oncogenesis. The antibodies are bispecific antibodies that comprises an antigen binding site that can bind an extracellular part of ERBB2 and an antigen binding site that can bind an extracellular part of ERBB3.

Abstract: As an antitumor drug which is excellent in terms of antitumor effect and safety and has an excellent therapeutic effect, there is provided an antibody-drug conjugate in which an antitumor compound represented by the following formula is conjugated to an anti-HER2 antibody via a linker having a structure represented by the following formula: -L1-L2-LP-NH—(CH2)n1-La—(CH2)n2—C(?O)—wherein the anti-HER2 antibody is connected to the terminal L1, and the antitumor compound is connected to the carbonyl group of the —(CH2)n2—C(?O)— moiety with the nitrogen atom of the amino group at position 1 as the connecting position.

Abstract: The present disclosure relates to, among other things, methods for degrading targeted surface proteins using the ubiquitin pathway by using a bispecific binding agent or an immunoconjugate that binds the targeted surface protein and a membrane-associated ubiquitin E3 ligase. The present disclosure also relates to methods for degrading targeted surface proteins using the ubiquitin pathway using an engineered transmembrane protein that binds the targeted surface protein and exhibits ubiquitin E3 ligase activity. The disclosure also provides compositions and methods useful for producing such bispecific binding agents and engineered transmembrane proteins, immunoconjugates, nucleic acids encoding same, host cells genetically modified with the nucleic acids, as well as methods for modulating an activity of a cell and/or for the treatment of various diseases such as cancers.

Abstract: The disclosure provides antibody immune cell inhibitor fusion proteins comprising four polypeptide chains that form two antigen binding sites and at least two immune cell receptor binding sites that inhibit or diminish activation of an immune effector cell when bound to a target antigen. The disclosure also provides antibody immune cell inhibitor fusion proteins comprising two polypeptide chains that form one antigen binding site and at least one immune cell receptor binding site that inhibit or diminish activation of an immune effector cell when bound to a target antigen. The disclosure further provides pharmaceutical compositions and kits that comprise such antibody immune cell inhibitor fusion proteins, and methods of treatment using such proteins.

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

Abstract: Provided are antibodies specific for human QSOX1 and methods of using these antibodies or antigen binding regions thereof in assays to detect QSOX1, to inhibit QSOX1, for use in other assay systems, and for use in treating cancer.

Abstract: The present disclosure is directed to human IgE antibodies and fragments thereof binding to galactose-?-1, 3-galactose, a known red meat allergen, and methods for use thereof.

Abstract: The disclosure provides novel methods and dosage regimens for use in treating or preventing pain, wherein the binding molecule comprises an NGF antagonist domain and a TNF? antagonist domain, wherein the NGF antagonist domain is an anti-NGF antibody or an antigen-binding fragment thereof and wherein the TNF? antagonist domain comprises a soluble TNF? binding fragment of TNFR.

Abstract: The present disclosure relates generally to immunoglobulin-related compositions (e.g., multi-specific antibodies or antigen binding fragments thereof) that can bind to the GPA33 protein. The multi-specific antibodies of the present technology are useful in methods for detecting and treating a GPA33-associated cancer in a subject in need thereof.

Abstract: A monomeric polysaccharide isolated from Auricularia auricula-judae (A. auricula), and a preparation method and use thereof are provided. The monomeric polysaccharide includes xylose, glucuronic acid, galactose, glucose, and mannose. The present disclosure further provides a structure and a preparation method of the monomeric polysaccharide isolated from A. auricula, and the preparation method adopts a plurality of chromatographic techniques. The monomeric polysaccharide isolated from A. auricula in the present disclosure is high-acetyl glucuronoxylogalactoglucomannan. The monomeric polysaccharide can reduce percentages of eosinophils, neutrophils, and lymphocytes in a lung lavage solution of a SiO2 dust-induced silicosis model mouse, significantly reduce levels of oxidative and inflammatory factors such as SOD, HYP, IL-6, and TNF-? in a SiO2 dust-induced silicosis model group in a dose-dependent manner, exhibit a protective effect for an experimental SiO2 dust-induced silicosis model mouse.

Abstract: The provided is a hydrogel that utilizes the naturally occurring substance pectin to exhibit an equivalent or greater effect. Specifically, the present application is intended to provide a hydrogel or a patch which is stable, has strong adhesive strength, is advantageous for drug delivery, can be used for sustained treatment, has extremely low cytotoxicity, and is unlikely to induce an immune response, and thus can be used on various body parts, in particular the oral cavity. In addition, the provide is a hydrogel patch which employs a freeze-drying method prior to crosslinking, and thus exhibits superior adhesion to patches employing a post-crosslinking freeze-drying method.

Abstract: A continuous polymerization reactor for super absorbent polymer is disclosed. The continuous polymerization reactor includes a cylindrical body; a discharge part with a diameter decreasing downward, positioned at a lower part of the body; an inlet positioned at an upper part of and connected to the body, into which a monomer composition is introduced; an outlet positioned at a lower part of the discharge part, from which hydrogel polymer is discharged; and a discharge valve opening or closing the outlet, wherein a ratio (H1/D1) of a sum (H1) of a height of the body and a height of the discharge part to a diameter (D1) of the body is 2 to 4. In addition, a continuous polymerization reaction system comprising the continuous polymerization reactor is also disclosed.

Abstract: Provided are a polyethylene having excellent processability and capable of reducing an injection molding defect rate, and a method of preparing the same. The polyethylene has an integral value in the region where the Log Mw is 5.5 or more in a GPC curve, wherein the x-axis is log Mw and the y-axis is dw/dlogMw, of 9% or less of the total integral value: and has a ratio (Tc10/Tc40) of a crystallization temperature (Tc10) measured at a cooling rate of 10° C./min to a crystallization temperature (Tc40) measured at a cooling rate of 40° C./min of less than 1.04.

Abstract: Provided are a polyethylene which is improved in terms of total volatile organic compounds (TVOCs) generated by low molecular weight polymers, thereby being suitable for fiber production, and a method of preparing the same.

Abstract: A method for producing a fluororesin composition for compression molding excluding ram extrusion molding, the method including: mixing a powder of a fluororesin A1 having a history of being heated to a melting point thereof or higher and an aqueous dispersion containing particles of a fluororesin B1 and having a solid concentration of 50% by mass or lower to provide a mixture; and drying the mixture to provide a fluororesin composition.

Abstract: A rubber composition is based on at least an elastomer matrix comprising more than 50 phr of a copolymer containing ethylene units and 1,3-diene units, the ethylene units in the copolymer representing more than 50 mol % of the monomer units of the copolymer; a 1,3-dipolar compound corresponding to the formula “Q-Sp-B” in which Q comprises a dipole containing at least and preferably one nitrogen atom, Sp, which is preferably divalent, is an atom or a group of atoms connecting Q to B, and B comprises a specific imidazole ring; a filler comprising predominantly silica and a crosslinking system comprising at least one radical polymerization initiator, and a co-crosslinking agent selected from the group consisting of (meth)acrylate compounds, maleimide compounds, allyl compounds, vinyl compounds and mixtures thereof.

Abstract: The invention provides a sealant film that enables easy removal of even viscous contents from a packaging bag, has sufficient heat-sealability, and high easy-peelability, as well as a packaging bag comprising the film. The sealant film contains a sealing layer including a resin composition comprising (a) a polypropylene resin and (b) a silicon containing polyolefin resin, wherein (1) the ratio of a sealing strength at a sealing temperature of 200° C. and a sealing pressure of 0.4 MPa to the sealing strength at a sealing temperature of 150° C. and a sealing pressure of 0.4 MPa is 2 or less, and (2) the sealing strength at a sealing temperature of 150° C. and a sealing pressure of 0.6 MPa is 40 N/15 mm or less.

Abstract: The present invention relates to an olefin-based polymer, particularly, to a low-density olefin-based polymer introducing a highly crystalline region and showing high mechanical rigidity.

Abstract: The present disclosure directs to the technical field of epoxy resins, and particularly relates to an antichlor and a preparation method as well as an application thereof, for solving problems in existing chlorine removal methods that separation efficiency of an epoxy resin containing hydrolyzable chlorine is low, lots of energy needs to be consumed in the separation process, molecular distillation equipment is expensive and requirements on vacuum degree and material tightness are high. The antichlor is a polymer containing keto-carbonyl groups. The preparation method includes: adding a mixed solution of styrene and ketene into a reactor containing an organic solvent; adding an initiator, a coupling agent and an anti-gelling agent into the reactor under an atmosphere of shielding gas; controlling the styrene and ketene to perform a polymerization reaction under first preset reaction conditions; and removing the organic solvent after completion of the polymerization reaction, thereby obtaining the antichlor.

Abstract: To provide a fluorinated copolymer capable of producing a cross-linked rubber article with excellent mold-releasing properties, a method for producing the fluorinated copolymer, a fluorinated copolymer composition, and a cross-linked rubber article. The fluorinated copolymer of the present invention is a fluorinated copolymer having units based on tetrafluoroethylene, units based on a perfluoro(alkyl vinyl ether), units based on a monomer having a fluorine atom and at least two polymerizable unsaturated bonds, and units based on a monomer having a nitrile group and a fluorine atom, wherein when the storage modulus of the fluorinated copolymer at an angular frequency of 0.3 rad/s is G?0.3 and the storage modulus of the fluorinated copolymer at an angular frequency of 0.03 rad/s is G?0.03 as determined by dynamic viscoelasticity measurement at 140° C., G?0.3/G?0.03 is from 1.00 to 1.45.

Abstract: Hydrogel materials used in the manufacture of biocompatible medical devices, for example, hydrogel materials having desirable physical properties for use as a contact lens. A composition contains at least one vinyl containing monomer, a methacrylate(acrylate) monomer, methacrylate (acrylate) prepolymers, crosslinking agents and monomers having the structure as shown in Formula 1: where R1 is a vinyl functionality capable of radical polymerization with specific preference for N-vinyl lactam derivatives and R2 is a zwitterionic functionality. The materials utilize a two-phase polymerization strategy.

Abstract: The present disclosure provides a polymer matrix composite comprising reinforcement fibres and a (meth)acrylate copolymer matrix formed from a (meth)acrylate monomer and a halogenated flame retardant monomer; a method of preparing the polymer matrix composite, and a composition for use in the method.

Abstract: Cationic cyclic amine containing polymers and copolymers as well as novel lipids have been designed and synthesized for efficient delivery of nucleic acids to cells in biological systems, specifically for in vitro cell transfection research.

Abstract: A monomer composition including (A) a phosphorylcholine group-containing polysiloxane monomer represented by the following formula (1), (B) a siloxanyl group-containing silicone monomer having at least one or more hydroxy groups in a molecule, represented by the following formula (2) or (3), (C) one or more hydrophilic monomers selected from hydroxyethyl (meth)acrylate, hydroxypropyl (meth)acrylate, and hydroxybutyl (meth)acrylate, (D) methacrylic acid, and (E) a hydrophilic monomer other than the component (C), a represents an integer of 20 to 500, b represents an integer of 1 to 70, c represents an integer of 1 to 70, d represents 0 or 1, p and q each represent 0 or 1, X represents —CH2— or —CH2CH2—, and R represents an alkyl group having 2 to 18 carbon atoms,

Abstract: A transparent article is obtained by molding a cyclic olefin copolymer or a resin composition containing the cyclic olefin copolymer. The cyclic olefin copolymer is obtained by a process that at least includes a step of preparing a norbornene monomer and ethylene as monomers in a polymerization vessel and a step of polymerizing the monomers in the polymerization vessel in the presence of a metal-containing catalyst. The metal-containing catalyst satisfies predetermined conditions.

Abstract: One embodiment of the present invention relates to a graft-modified product, an adhesive, an olefin resin composition, or a laminate, and the graft-modified product is a graft-modified product of at least one base polymer selected from polyolefins by a carbodiimide monomer having a carbodiimide group and a polymerizable double bond.

Abstract: A surface-treated filler obtained by surface-treating a surface of a filler with ?-butyl-?-(2-trimethoxysilylethyl)polydimethylsiloxane having a weight average molecular weight of 500 to 5,000, wherein an adhesion percentage of the ?-butyl-?-(2-trimethoxysilylethyl)polydimethylsiloxane to the filler is from 20.0 to 50.0% by mass.

Abstract: The present disclosure relates, according to some embodiments, to photostable photoactive compositions comprising (a) at least one photoactive compound that develops within itself an excited state energy when subjected to UV radiation and (b) a block copolymer comprising a plurality of blocks, wherein the block copolymer is operable to quench the excited state energy.

Abstract: Provided is a crosslinking rubber composition containing: a rubber-like polymer (A) having an iodine value of 10 to 250 (g/100 g), comprising 3% by mass or more of an ethylene structure and less than 10% by mass of a vinyl aromatic monomer block, containing a nitrogen atom, and having a modification ratio measured by column adsorption GPC of 40% by mass or more; and a crosslinking agent (B).

Abstract: A process for preparing a multiblock polymer by statistical copolymerization of a mixture containing ethylene and a 1,3-diene and subsequent polymerization of ethylene in the presence of a rare-earth metallocene and an organomagnesium reagent RB—(Mg—RA)m—Mg—RB or X—Mg—RA—Mg—X is provided. According to the formula, RA is a divalent aliphatic hydrocarbon-based chain optionally interrupted with one or more oxygen or sulfur atoms or arylene groups, RB comprises a benzene nucleus substituted with the Mg atom, one of the carbon atoms of the benzene nucleus ortho to the Mg is substituted with a methyl, an ethyl or an isopropyl or forms a ring with the carbon atom which is its closest neighbour and which is meta to the Mg. The other carbon atom of the benzene nucleus ortho to the Mg is substituted with a methyl, ethyl or isopropyl, X being a halogen atom, m being greater than or equal to 1.

Abstract: A composition contains at least one aldehyde (A), at least one phenolic compound (B), and at least one amine (C) bearing at least two amino groups selected from primary and secondary amino groups. At least one of these compounds bears at least one (meth)acrylate group. A fibre-reinforced composition contains the composition. The compositions can be cured in a process, and fibre composite materials/thermosets are obtainable by the process.

Abstract: The present invention relates to polyester polyol and polyurethane prepared from the polyester polyol, the polyester polyol being prepared from an acid component containing at least one type of pure isophthalic acid (PIA) and phthalic anhydride (PA) and an alcohol component represented by chemical formula 1: HO-L3-OH??[Chemical Formula 1] L3 is a straight or branched chain alkylene group having 2 to 6 carbon atoms substituted or unsubstituted with a hydroxyl group; or a straight or branched chain ether group having 2 to 6 carbon atoms substituted or unsubstituted with a hydroxyl group. The polyester polyol according to the present invention has excellent storage stability and compatibility, and the polyurethane prepared using the polyester polyol has excellent flame retardancy and dimensional stability.

Abstract: A polyetherester polyol is synthesized from reactants including a) aromatic acid or aromatic anhydride or a mixture thereof, and b) OH-functional starter molecules which contain alcoholamine or amine-initiated polyether polyol. Corresponding rigid polyurethane foams produced with the polyetherester polyol are useful for insulation used in appliance applications.

Abstract: A prepolymer comprising acid functionality is made by a process comprising the step of contacting: (i) a di-isocyanate, (ii) a diol containing an acid group, and (iii) a polyol without an acid group, the contacting conducted under reaction conditions and in a solvent consisting essentially of dipropylene glycol dimethyl ether. The prepolymer is useful in the preparation of water-based polyurethane dispersions.

Abstract: A xylylene diisocyanate composition according to exemplary embodiments includes xylylene diisocyanate (XDI) and chloromethylbenzyl isocyanate (CBI), and may satisfy a predetermined relationship between an acidity and a content of CBI. Thereby, an optical lens having a high transmittance and improved optical uniformity can be manufactured by controlling a polymerization reaction rate.

Abstract: A modified polyurethane carrier substrate is provided. The modified polyurethane carrier substrate is formed from a modified polyurethane. The modified polyurethane includes a soft segment and a hard segment. The soft segment is formed from a polyol. The hard segment is formed from diisocyanate and a chain extender. The chain extender is dianhydride. A common logarithm of a ratio of a storage modulus of the modified polyurethane carrier substrate at ?30° C. to a storage modulus of the modified polyurethane carrier substrate at 150° C. ranges from 0.40 to 1.30.

Abstract: A process for producing a thermoplastic polyoxazolidinone comprising copolymerizing a diisocyanate compound with a bisepoxide compound in the presence of a catalyst, in a solvent, wherein the solvent (E) comprises at least one of a substituted or unsubstituted alkyl nitrile, a substituted or unsubstituted alkenyl nitrile, a substituted or unsubstituted cycloalkyl nitrile, a substituted or unsubstituted aryl nitrile, a substituted or unsubstituted alkylcycloalkyl nitrile, a substituted or unsubstituted alkylaryl nitrile, a substituted or unsubstituted hetercycloalkyl nitrile, a substituted or unsubstituted heteroalkyl nitrile, and a substituted or unsubstituted heteroaryl nitrile, preferably a substituted or unsubstituted aryl nitrile. The invention is also related to the resulting thermoplastic polyoxazolidinone.

Abstract: The present disclosure relates to the technical field of the epoxy resin, specifically, relates to a preparation method a low-chlorine epoxy resin and use thereof, which can solve the problem of a high total chlorine content in the epoxy resin to a certain extent. The preparation method of a low-chloride epoxy resin comprises: loading a metal oxide as a stationary phase on a grid inside a reaction kettle; the reaction kettle being externally connected to an alternating-current power supply, and under a first pre-set condition, diluted epoxy resin containing a chlorine impurity, as a mobile phase, flowing through the grid loaded with the metal oxide; the epoxy resin containing a chlorine impurity contacting and reacting with the metal oxide to obtain a purified epoxy resin.

Abstract: The present invention relates to a polymeric Mannich base useful as an epoxy curative and/or accelerator, which has an improved safety profile due to the avoidance of the use of phenol in its preparation.

Abstract: A method of spontaneously patterning a polymer during frontal polymerization includes activating an initiation region of a monomer solution to reaction to initiate a polymerization reaction. A polymerization front is generated and propagates through the monomer solution in a radial or longitudinal direction away from the initiation region. The monomer solution is spontaneously heated downstream of the polymerization front by thermal transport away from the polymerization reaction. Once a localized region of the monomer solution reaches a temperature sufficient for spontaneous initiation of another polymerization reaction, a new polymerization front is generated and propagates through the monomer solution in a circumferential or transverse direction.

Abstract: One embodiment of the present invention relates to a polymer, a composition, a cured product, a laminate, or an electronic component, and the polymer has a repeating structural unit represented by Formula (1) and has a group Y represented by Formula (a) at a terminal: wherein X's are each independently —O—, —S—, or —N(R3)—, R3 is a hydrogen atom, a monovalent hydrocarbon group having 1 to 20 carbon atoms, a monovalent halogenated hydrocarbon group having 1 to 20 carbon atoms, or a group obtained by substituting a part of the hydrocarbon group or the halogenated hydrocarbon group with at least one selected from an oxygen atom and a sulfur atom, R1 is a divalent organic group, and R2 is a divalent unsubstituted or substituted nitrogen-containing heteroaromatic ring; —Y??(a) wherein Y is a group containing an ethylenically unsaturated double bond and having 3 to 50 carbon atoms, an unsubstituted or substituted aromatic hydrocarbon group having 6 to 50 carbon atoms, an unsubstituted or substituted