Abstract: It is an object of the present invention to provide a method or an immunochromatographic test piece, which controls a speed or a direction of development of a specimen on the immunochromatographic test piece, so that a treatment with an acid reagent, nitrite, and a neutralizing reagent is properly controlled. The present invention provides an immunochromatographic test piece for extracting and measuring a sugar chain antigen in a specimen, the immunochromatographic test piece having a neutralizing region impregnated with a neutralizing reagent upstream of a label region, and further having a solid acid reagent or nitrite region impregnated with a solid acid reagent, or with nitrite, upstream of the neutralizing region, wherein a resin-made sheet is sandwiched between the solid acid reagent or nitrite region the neutralizing region so as to suppress the movement of a reagent or the movement of a specimen solution between the regions.

Abstract: The invention encompasses methods and test strips for detecting the presence of cerebrospinal fluid (CSF) in a biological sample with a lateral flow device which uses lectin conjugates, anti-antigen conjugates, an immobilized serum line, and an immobilized anti-antigen line.

Abstract: A multiplexed lateral flow device includes an impermeable internal reservoir having an opening to receive a sample deposition. A fluid distributor pad is arranged in fluid communication with a lower surface of the internal reservoir. The fluid distributor pad includes a paper based microfluidic element having a pattern of a hydrophobic material to distribute a portion of the sample deposition substantially equally among a plurality of flow paths. Lateral flow assays having a plurality of flow lines are aligned with flow paths of the distributor pad. An impermeable top cover has a first window arranged over the opening of the internal reservoir, and at least a second window arranged over the test results of the lateral flow assays. A housing element houses the reservoir, the distributor pad and lateral flow assays.

Abstract: The present disclosure relates to a sensor for the detection of analytes, in particular for the detection of biomolecules. The sensor includes a (bio)compatible sensing layer including a polymer matrix or gel matrix, particularly a polymer gel matrix, organic nanoparticles and, optionally, one or several cell adhesion layer(s). The cell adhesion layer(s) can be varied depending on the type of cells. In the presence of the analytes, the organic nanoparticles are capable of photon up-conversion emission. The sensor further optionally includes plasmonic metal nanoparticles. The present disclosure further relates to methods of producing such a sensor and to uses of such a sensor.

Abstract: The present invention relates to the field of medicine and in particular to Parkinson's disease (PD). Specifically the present invention relates to methods and means for early detection of PD. The invention relates also to methods and means for treatment or prophylaxis of PD. In the method of the invention a probability of a subject developing or having Parkinson's disease (PD) is determined by measuring the relative abundances of one or multiple microbial taxa in a sample from a subject; and the probability of the subject developing or having PD is determined based on the measured abundances. The present invention provides a novel approach for the diagnostics of PD.

Abstract: Methods described herein include receiving data from flowing a plurality of aptamers over a sample of tumor cells randomly affixed to a surface of a microfluidic device. The tumor cells may include one or more unknown tumor subtypes of cells. The plurality of aptamers may include a plurality of aptamer families. Each aptamer family of the plurality of aptamer families may be determined to bind to at least one possible subtype of the tumor cells. The data may include a measure of binding affinity of each aptamer family to the tumor cells. The method may include analyzing the measure of the binding affinity of each aptamer family to the tumor cells. The analyzing may include classifying the binding affinity. The method may also include determining one or more aptamer families that characterize the one or more unknown tumor subtypes of cells based on the classifying.

Abstract: Provided herein are methods and compositions for the identification of modulators of ApoE-induced LILRB activation. Also provided herein are methods of treating cancer comprising the administration of an inhibitor of ApoE-induced LILRB activation. Also provided are methods of treating autoimmune disease or inhibiting the onset of transplant rejection or treating an inflammatory disorder comprising administering an agonist of ApoE-induced LILRB activation to a subject.

Abstract: The invention relates to antibodies, which bind a peptide having a sequence selected from SEQ ID NO: 2, or a fragment or derivative of such an antibody having essentially the same antigen specificity. In particular, the antibodies suited to be used to detect, manage or monitor cancer in a subject, particularly cancer with interleukin-4 induced gene 1 (IL4I1) expressing cells. The invention also relates to kits or devices containing said antibodies, suitable for immunologic detection or reaction from any biological sample.

Abstract: The present invention is related to a method of detecting an endotoxin in a sample using a chromogenic assay, the method comprising: (a) contacting the sample with a reagent comprising limulus amebocyte lysate (LAL) and a chromogenic substrate; and (b) measuring a chromogenic effect resulting from a change in the chromogenic substrate in the presence of endotoxin in the sample; wherein the LAL is substantially free of coagulogen. The method also relates to compositions and kits comprising LAL substantially free of coagulogen, and methods of making such.

Abstract: Glycans having a branched structure are labeled with a labeling agent, such as 2-aminobenzoic acid, having one site that is easily negatively charged. At this time, reduction which is usually performed in labeling by reduction amination is not performed. A sample for mass spectrometry containing the labeled form of glycans thus obtained is prepared, and is subjected to MS/MS analysis in negative ion mode. In the MS/MS spectra obtained by the MS/MS analysis, peaks of E ions, D ions and the like which reflect the branched structure clearly appear. As a result, structural analysis of an entirety of the glycan including the branched structure can be easily performed.

Abstract: Disclosed herein are embodiments of a signaling conjugate, embodiments of a method of using the signaling conjugates, and embodiments of a kit comprising the signaling conjugate. The disclosed signaling conjugate comprises a latent reactive moiety and a chromogenic moiety that may further comprise a linker suitable for coupling the latent reactive moiety to the chromogenic moiety. The signaling conjugate may be used to detect one or more targets in a biological sample and are capable of being covalently deposited directly on or proximally to the target. Particular disclosed embodiments of the method of using the signaling conjugate comprise multiplexing methods.

Abstract: The present subject matter provides urea biosensors as well as compositions, devices, and methods comprising such biosensors.

Abstract: The invention, in part, includes methods of single molecule protein sequencing that include using weak binding spectra in the amino acid identification.

Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.

Abstract: The field of this invention relates to immunohistochemistry (IHC) and in situ hybridization (ISH) for the targeted detection and mapping of biomolecules (e.g., proteins and miRNAs) in tissues or cells for example, for research use and for clinical use such by pathologists (e.g., biomarker analyses of a resected tumor or tumor biopsy). In particular, the use of mass spectrometric imaging (MSI) as a mode to detect and map the biomolecules in tissues or cells for example. More specifically, the field of this invention relates to photocleavable mass-tag reagents which are attached to probes such as antibodies and nucleic acids and used to achieve multiplex immunohistochemistry and in situ hybridization, with MSI as the mode of detection/readout. Probe types other than antibodies and nucleic acids are also covered in the field of invention, including but not limited to carbohydrate-binding proteins (e.g., lectins), receptors and ligands.

Abstract: Kits and methods to distinguish between false and true labor are provided. The kits and methods can utilize differences in abundance and/or differences in the rate of change in abundance of B7-H2, SORC2, TF, C1-Esterase Inhibitor, Ran, IMDH1 and/or PGAM1, as markers of true labor.

Abstract: Methods and assays for diagnosis or prognosis of endometriosis include comparing an expression level or activity of miR-155 and JARID2 in a sample to detect a measurable difference. Therapeutic methods for treating endometriosis in a subject comprise identifying a subject as having a decreased expression level and/or activity of JARID2 in a sample obtained from the subject; and administering an agent that inhibits an activity of an miRNA that targets JARID2 or an agent that inhibits EZH2. Methods for screening for a compound useful for treating endometriosis are also provided and include contacting a cell with an effective amount of a test compound, and detecting whether the expression level or activity level of JARID2 or miR-155 in the cell is altered in the presence of the test compound.

Abstract: Methods are disclosed herein for determining whether a subject has a Tauopathy, such as Pick disease, Alzheimer disease, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) or argyrophilic grain disease (AGD). These methods utilize an amyloid seeding assay.

Abstract: A detector assembly and method of detecting the presence of a biomarker, such as bilirubin, in a sample of a flowable substance and a detector unit (1) are disclosed. The method comprises providing a receiver body (2) shaped to define a receiving chamber (3). The receiving chamber (3) has an outlet opening (5) through which a flowable substance can leave the receiving chamber (3). The receiving chamber (3) has a maximum capacity for holding a volume of the flowable substance. A quantity of the flowable substance is supplied to the receiving chamber (3) and caused to pass through the outlet opening. The receiver body (2) can move relative to a guide (10) of the receive body (2) from a first position in which the outlet opening (5) is blocked to a second position in which the outlet opening (5) is not blocked. In the second position, a metered quantity of flowable substance in the receiving chamber (3) can leave the receiving chamber (3).

Abstract: Quality control formulations that do not require human donor-derived blood components for use in testing the efficacy of viscoelastic analysis reagents, and methods for preparing these formulations, are described.

Abstract: A chemical sensing system is described. The chemical sensing system can include a plurality of sensors arranged on at least one substrate. The sensors may have differing sensitivities to sense different analytes, and may each be configured to output a signal in response to sensing one or more of the different analytes. The chemical sensing system can further include a computer processor programmed to receive the signals output from the plurality of sensors. The computer processor may be further programmed to determine a concentration of analytes in the sample based, at least in part, on the received signals and a model relating the signals or information derived from the signals to an output representation having bases corresponding to analytes.

Abstract: Provided is an automated analyzer comprising a temperature regulator that can be made more compact in size while maintaining high-precision temperature regulation. In a temperature-regulating unit (20) of the automated analyzer, a first chemical reservoir (1) is constituted by a large-diameter spiral-shaped pipe, and a second chemical reservoir (2) is constituted by a large-diameter chemical reservoir container. The first chemical reservoir (1), which is positioned upstream of the second chemical reservoir (2), has an internal capacity that is set so as to be greater than the volume of a single discharge of each of syringe pumps (29, 30, 31), and the second chemical reservoir (2) also has an internal capacity (volume) that is set so as to be greater than the volume of a single discharge of each of the respective syringe pumps (29, 30, 31).

Abstract: The present disclosure is directed to methods and devices for reducing or otherwise mitigating accumulated reagent material and/or fluids within a dispense nozzle of a dispenser.

Abstract: It is intended to provide a kit or a device for the detection of lung cancer and a method for detecting lung cancer. The present invention provides a kit or a device for the detection of lung cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample from a subject, and a method for detecting lung cancer, comprising measuring the miRNA in vitro.

Abstract: A wheel sensor device for a vehicle may include: a first sensor part having a first fixing hole, inserted into an insertion space of a knuckle of a vehicle, and configured to sense wheel speed of the vehicle; a second sensor part overlapping the first sensor part, inserted into the insertion part with the first sensor part, having a second fixing hole aligned with the first fixing hole, and configured to sense the wheel speed; and a fixing member fixed to a mounting structure of the knuckle through the first and second fixing holes.

Abstract: A sensor module includes: a printed circuit board having a first recessed portion formed at a first side, a second recessed portion formed at a second side facing the first side, a third recessed portion formed at a third side, and a fourth recessed portion formed at a fourth side facing the third side; a metal cap including convex portions each bonded to a respective one of the first to fourth recessed portions; and a first inertial sensor and a second inertial sensor that are provided at a main surface of the printed circuit board. The first inertial sensor and the second inertial sensor are disposed outside a region surrounded by a line connecting both ends of the first recessed portion and the second recessed portion and outside a region surrounded by a line connecting both ends of the third recessed portion and the fourth recessed portion.

Abstract: An accelerometer sensor includes a casing, a pendulum fixed to the casing, a movable electrode carried by the pendulum and connected to a detection circuit, a first electrode and a second electrode rigidly attached to the casing to form, with the moving electrode, two capacitors of variable capacitance depending on a distance between the electrodes. The accelerometer sensor further includes a control unit that carries out detection operations to measure the variable capacitances of the capacitors. The control unit also performs a control operation of the movable electrode depending on the capacitances measured by applying a logic signal for controlling a switch for selective connection of the fixed electrodes to an excitation circuit delivering a control signal to the fixed electrodes in order to keep the pendulum in a predetermined position.

Abstract: Various approaches for automated fall detection, implemented in wearables and other device form factors of a personal emergency response system (PERS) are disclosed. In an example, a hybrid approach for fall detection includes: identifying a potential fall event from three-dimensional motion data of a human subject, using filtering rules; evaluating the motion data with a machine learning model (e.g., a decision tree ensemble (DTE) model), to produce a first determination that a fall has occurred; evaluating the motion data with a deep learning neural network (e.g., recurrent neural network such as a gated recurrent unit (GRU)), to produce a second determination that a fall has occurred; classifying the potential fall event as a fall condition for the human subject, based on the first determination and the second determination; and outputting data to indicate the fall condition for the human subject.

Abstract: Methods and devices for checking the geometry of an angle-of-attack sensor belonging to an aircraft are provided. The device includes one or more stages, a stage comprising a slot the geometric dimensions of which are specifically configured to accept a portion of the said angle-of-attack sensor. The device allows a visual inspection but can also be instrumented (photoelectric cell, laser, camera) in order to verify the geometry of the sensor in detail. Developments notably describe the use of signal indicators, motorized stages, one or more image sensors, specific materials, communications with computers, or placement by drone and/or robotic arm. Software aspects are described.

Abstract: A system for checking an inertial measurement unit of a vehicle, in particular a land vehicle, during driving includes the inertial measurement unit having: a first acceleration sensor configured to measure a translational acceleration along a first sensor axis and/or a first rate-of-rotation sensor configured to measure a rate of rotation about the first sensor axis and also a second acceleration sensor configured to measure a translational acceleration along a second sensor axis and/or a second rate-of-rotation sensor configured to measure a rate of rotation about the second sensor axis. A sensing device senses a movement of the vehicle in a first vehicle direction and/or about the first vehicle direction. Both the first sensor axis and the second sensor axis are tilted with respect to the first vehicle direction.

Abstract: Provided are embodiments including a system for performing health monitoring. The system includes a measurement device configured to measure pressure of an environment, a heating element of the heater section coupled to the measurement device, a first sensing element operably coupled to a first region of the measurement device, and a second sensing element operably coupled to a second region of the measurement device. The system also includes a programmable logic that is configured to generate a status signal or flag based at least in part on conditions of the first region or the second region of the measurement device, a processing system configured to control the heating element responsive to reaching a threshold temperature, and a display configured to display a status of the first region or second region of the measurement device based at least in part on the status signal or flag.

Abstract: An apparatus for measuring a speed of a vehicle having an in-wheel motor including a lock nut part fixed to an outer portion of a rotation shaft rotated by receiving power of the in-wheel motor, and restricting movement of a bearing part positioned outside the rotation shaft; a connection part coupled to the lock nut part; a magnet part having a magnetic force, and fixed to the connection part; and a speed sensor part installed to be separated from the magnet part, and measuring rotations of the magnet part.

Abstract: A laser radar device calculates a wind speed for each of a plurality of divided sections obtained by dividing a trajectory drawn by a laser beam in front of a wind turbine.

Abstract: Active cantilever probes having a thin coating incorporated into their design are disclosed. The probes can be operated in opaque and/or chemically harsh environments without the need of a light source or optical system and without being significantly negatively impacted by corrosion. The probes include a substrate that has a cantilever, a thermomechanical actuator associated with the cantilever, a piezoresistive stress sensor disposed on the cantilever, and a thin coating disposed on the cantilever and the piezoresistive stress sensor. The coating is bonded to the substrate, is thermally conductive, and has a low thermal resistance. Further, the thin coating is configured to have little to no impact on one or more of a mass of the active probe, a residual stress of the cantilever, or a stiffness of the active probe. Techniques for performing topography and making other measurements in an opaque and/or chemically harsh environment are also provided.

Abstract: An apparatus includes a tester chassis connected to a chassis electric reference potential for electrostatic discharge grounding of the tester chassis; a thermal head assembly coupled to the tester chassis, the thermal head assembly having a metallic thermal contact surface; and an electrical insulation arrangement disposed between the metallic thermal contact surface and the chassis electric reference potential to electrically insulate the metallic thermal contact from the chassis electric reference potential. An electrolytic corrosion protection system for the apparatus and a cable assembly for the apparatus.

Abstract: A test carrier carried in a state of accommodating a device under test (DUT) includes: a carrier body that holds the DUT; a lid member that covers the DUT and is attached to the carrier body; and an identifier for identifying an individual of the test carrier.

Abstract: Embodiments are directed to probe structures, arrays, methods of using probes and arrays, and/or methods for making probes and/or arrays wherein the probes include at least one flat tensional spring segment.

Abstract: An automated high speed test solution for Quad Flat Pack device packages that enables connectivity between test equipment and the integrated circuit under test is described. A test probe geometry that provides highly repeatable and reliable connections suitable for use with consumer grade QFP devices coupled with ease of maintenance is provided. In some embodiments, the probe tip ends are chisel-shaped. The probes can be slightly slanted with respect to a vertical axis of the probe retaining block.

Abstract: Provided are an automatic trigger type identification method and device and an oscilloscope, which belong to the field of oscilloscopes. The method includes analyzing characteristic parameter data of a to-be-triggered signal. The characteristic parameter data comprises at least one of bus protocol matching information or variation information of at least one characteristic parameter. In this way, a trigger type capable of stably triggering the to-be-triggered signal can be obtained for user selection or automatic selection for trigger.

Abstract: The present disclosure relates to a voltage measuring method, a computer device and a storage medium. The method includes: determining, by a voltage measuring device when the voltage measuring device is electrically coupled to a three-phase conductor through a voltage dividing capacitor in the voltage measuring device, a current measured voltage, the measured voltage being determined by measuring a voltage of the voltage dividing capacitor in the voltage measuring device; adjusting the coupling capacitances, and determining, by the voltage measuring device after the adjustment of the coupling capacitances, a current measured voltage; and determining, based on the measured voltage by the voltage measuring device before the adjustment of the coupling capacitances and the measured voltage by the voltage measuring device after the adjustment of the coupling capacitances, a voltage of a phase conductor of the three-phase conductor to be measured.

Abstract: Magnetic current sensor, including: a sensor bridge circuit including a first and second half-bridges, each including two series-connected and diagonally opposed tunnel magnetoresistive (TMR) sensor elements, the TMR sensor elements including a reference layer oriented a single predetermined direction and a sense layer having a sense magnetization; a field line configured for passing a field current generating a magnetic field adapted for orienting the sense magnetization of the diagonally opposed TMR sensor elements of the first half-bridge and of the diagonally opposed TMR sensor elements of the second half-bridge in an opposite direction; such that a non-null differential voltage output between the TMR sensor elements of the first half-bridge and the TMR sensor elements of the second half-bridge is measurable when the field current is passed in the field line; the differential voltage output being insensitive to the presence of an external uniform magnetic field.

Abstract: In a meter for performing a measurement of an electrical parameter, an output from a sensor is sampled to produce at least one sample, and an iterative method is performed comprising: producing further samples; holding in memory a stored array of samples comprising the at least one sample and each of the further samples from each iteration; determining a measure of statistical variability of a mean for the respective iteration from a measure of statistical variability and from the number of samples used to generate the measure of statistical variability; comparing the measure of statistical variability of the mean with a pre-determined threshold; and generating an electrical signal indicating a state of the measurement if the measure of statistical variability of the mean of the samples taken during the measurement is less than or equal to the pre-determined threshold.

Abstract: Methods and systems for emulating high side current of a power switch including low and high side switches. The method includes generating, with a low side current sensor, a low side current signal for the low side switch when the power switch is in a low state. The method also includes generating, with a first transconductance amplifier, an emulated current signal based on an input voltage of the power switch. The method further includes generating, with a buffer, a fixed reference voltage by sampling the low side current signal when the power switch changes from the low state to a high state. The method also includes generating, with a capacitor, an emulated voltage based on the emulated current signal and the fixed reference voltage. The method further includes, generating, with a second transconductance amplifier, a high side current signal for the high side switch based on the emulated voltage.

Abstract: Online estimation of area-level inertia can be used for frequency stability control in low-inertia power systems. This disclosure provides an area-level inertia online estimation method considering inter-area equivalent frequency dynamics. The disclosed method only needs one phasor measurement unit placed at any bus within each area. The inter-area equivalent frequency dynamics model for the multi-area power system is developed, which is employed to estimate area-level inertia under the small disturbance situation. Then, the area-level inertia estimation model boils down to a nonlinear parameter identification problem. The other boundary conditions of the disclosed method are derived by parameter identifiability.

Abstract: A method includes obtaining electrical measurements of an input signal of a power system. The electrical measurements are obtained at a sampling frequency and the input signal is indicative of an operating frequency of the power system. The method includes generating an intermediate signal from the input signal. The intermediate signal has a direct current (DC) component indicative of a magnitude and a phase of the input signal. The method includes filtering the intermediate signal using an adjustable length filter to obtain the magnitude and the phase of the input signal. The length of the adjustable length filter varies based at least in part on a period measurement of the power system.

Abstract: A spectrum analyzer having a memory function to adopt a digital-data-based frequency sweep scheme while achieving performance comparable to performance of a high-speed FFT spectrum analyzer, and a method of controlling the spectrum analyzer, in which the spectrum analyzer includes: an ADC for converting a BWP signal, which is at least one analog unit frequency band signal, into a digital data sample at a predetermined sample rate according to a span set by a user; a digital sweep part for sweeping the data sample passed through the ADC while digitally decimating the data sample through a decimation processing block having a two-stage cascaded structure, and processing the swept data sample to increase a frequency sweep speed; and a control unit for controlling the digital sweep part according to various items input, set, and selected by the user to perform spectrum analysis and output a spectrum analysis result.

Abstract: A method and apparatus for measuring an unknown impedance. The apparatus comprises a first input to receive a first signal generated by a first portion of a sensor circuit, the first portion comprising an unknown impedance and a first known resistance, the unknown impedance to vary based upon a phenomenon to be measured by the sensor circuit. The apparatus also comprises a second input to receive a second signal generated by a second portion of the sensor circuit, the second portion of the sensor circuit comprising a known impedance and a second known resistance. And the apparatus comprises control logic to, based on a difference in time at which each of the first input and the second input reach a reference voltage, determine a measurement of the sensor circuit.

Abstract: A method of measuring a fuse resistance includes steps as follows. A predetermined voltage value of a force voltage on a common ground (CGND) bus electrically connected to at least one fuse element, a first current value of a measured current through the CGND bus in a first condition, and a second current value of another measured current through the CGND bus in a second condition are preloaded. The second current value is subtracted from the first current value, so as to get a subtracted current value, thereby removing a value of a leakage current through the CGND bus. The predetermined voltage value is divided by the subtracted current value to equal the fuse resistance of the at least one fuse element.

Abstract: An inspection device inspects a display for defects. The display includes a power supply, a circuit board having a stabilizer to stabilize the power supply, a display panel which is electrically connected to the circuit board and has a first electrode, and an input sensor which is disposed on the display panel and has a second electrode. The inspection logic measures a value of capacitance between the first electrode and the second electrode of the display, and includes a frequency setter that sets a driving frequency of the second electrode to a frequency in a predetermined range.

Abstract: To provide an electric potential measuring device that can further improve evaluation quality.