Abstract: Aspects discussed herein relate to spirometers that can be used to measure lung function using a mobile device. A user can breathe into a mouthpiece that forces the user's breath through a spirometric encoding assembly. The spirometric encoding assembly can be coupled to a mobile device using a spirometric encoding adapter. The spirometric encoding assembly can generate one or more outputs based on the user's breath; this data can be measured using one or more sensors of the mobile device. The data captured by the mobile device can be processed to determine the flow rate and/or volume of the user's breath. The flow rate and volume can be used to determine a variety of characteristics of the user's health, lung capacity, and/or for diagnosing medical conditions.

Abstract: Systems and methods described herein provide techniques for analyzing gait and posture of a subject with respect to control data. The systems and methods, in some embodiments, processes video data, identifies keypoints representing body parts, determines metrics data at a stride level, and compares the metrics data to control data.

Abstract: A platform for monitoring range of motion in a joint includes initiating a range of motion monitoring application and connecting the application to a video communication platform. Video data, comprising the joint of the patient, is received from the communication platform. The platform may be used to determine that the patient is in position for calculating a range of motion of the joint, and capture an image of the joint from the received video data. The platform receives, from a user, a selection of a first set of points used in measuring range of motion, and calculates a first angle measurement associated with the range of motion of the joint based on the selected set of points. The captured image is displayed together with an overlay comprising the first set of points and the first calculated angle, and the captured image and the overlay are stored to a storage device.

Abstract: This document discusses systems, devices, and methods for monitoring and managing patients with chronic pain. A patient monitoring system comprises a sensor circuit to sense a physiological or functional signal indicative of or correlated to patient mobility, an electrostimulator to generate and deliver neuromodulation therapy to the patient, and a controller circuit to generate a mobility metric using the sensed physiological or functional signal. The mobility metric represents respective times spent in different activity intensity levels associated with one or more types of activities during a specific time period. The controller circuit can trend the mobility metric over time and determine a progress toward a personalized mobility goal of the patient, and control the electrostimulator to initiate or adjust the neuromodulation therapy in accordance with the trended mobility metric or the determined progress toward the mobility goal.

Abstract: A physiological monitor uses patterns of motion during strength training activity, e.g., as detected by a wearable monitor, to evaluate a degree of muscular, musculoskeletal, and/or biomechanical strain experienced by a user while engaged in strength training. The resulting strain may advantageously be quantified and used to provide coaching recommendations, update daily strain metrics, and take other responsive actions.

Abstract: An optical sensor includes a waveguide for directing, receiving, and coherently mixing electromagnetic radiation from an electromagnetic radiation source to detect one or more physical phenomena. The waveguide is integrable into a printed circuit board, allowing the optical sensor to maintain a small footprint.

Abstract: Some embodiments of the disclosure provide non-contact health monitoring and physiotherapy equipment. In some examples, the equipment includes a bed, a monitoring module, a physiotherapy module, a displacement device, and a machine vision monitoring device. An execution part of the displacement device is connected to the bed and/or the monitoring module to enable at least one of the bed and the monitoring module to move relative to each other. The machine vision monitoring device is mounted on the bed or the monitoring module and connected to the displacement device in a communication manner. The machine vision monitoring device is configured to identify a limb position of the patient lying on the bed to provide coordinates for moving monitoring module to the displacement device. The displacement device is configured to drive the monitoring module to align with any part of the bed from any angle.

Abstract: A system for detecting target molecules in a patient's saliva includes an oral appliance and a cassette removably coupled to the oral appliance. According to an aspect, the cassette includes a microtubule including a collection portion. A detector is configured to transmit light through the removable cassette, measure the amount of light transmitted through the microtubule, determine an absorption or scattering amount of the light, and determine whether the target molecules are present in the patient's saliva based on the absorption or scattering amount of the light.

Abstract: According to an aspect, there is provided a system (10) comprising a sweat stimulation device (100) for stimulating sweat generation from sweat glands of a subject, the device comprising: a stimulation element (102) configured to provide modulated stimulation between two non-zero states to the sweat glands through the skin of the subject; and a sensor (104) for measuring data indicative of a characteristic of sweat generated by the sweat glands in response to the stimulation; and a processor (110) configured to receive the measured data from the sensor; compare the measured data with a threshold value; and responsive to determining that the measured data meets or exceeds the threshold value, generate an alert signal.

Abstract: A method of generating a blood glucose estimation for a subject includes receiving real-time PPG data from a PPG sensor attached to the subject, and generating a blood glucose estimation for the subject via an adaptive predictive model using the real time PPG data. The method includes receiving a real-time measurement of blood glucose via a blood glucose monitoring device attached to the subject and, in response to receiving the real-time measurement of blood glucose, updating one or more parameters of the model in real-time to improve blood glucose estimation accuracy of the model. The method may also include detecting whether the generated blood glucose estimation is above or below a threshold and, in response to determining that the generated blood glucose estimation is above or below the threshold, receiving a real-time measurement of blood glucose and then updating the parameters of the model to improve blood glucose estimation accuracy of the model.

Abstract: An oximeter device determines an oxygen saturation for the tissue and determines a quality value for the oxygen saturation and associated measurements of the tissue. The quality value is calculated from reflectance data received at the detectors of the oximeter device. An accelerometer of the oximeter device can detect movement of the oximeter device when oximetry measurements are made by the oximeter device. An amount of the movement is an indicator of a probe face of the oximeter device changing position with respect to the tissue when the measurements are made. The accelerometer information is used by the oximeter device to adjust the quality value to reflect the amount movement. The oxygen saturation and the adjusted quality metric value are displayed on a display of the oximeter device so that a user may view the quality of the displayed information.

Abstract: An apparatus for measuring blood components, includes: an impedance sensor configured to measure a bio-impedance of a user; and a processor configured to measure, by using a multiple-output artificial neural network (ANN) learning model, a concentration of a basic blood component and a concentration of at least one auxiliary blood component associated with the basic blood component, based on user metadata and the measured bio-impedance.

Abstract: An intraoperative tissue oximetry device includes a tissue marker that includes one or more pens or one or more similar ink sources, such that the tissue marker can mark tissue according to oxygen saturation measurements made by the tissue oximetry device, thereby visually delineating regions of potentially viable tissue from regions of potentially nonviable tissue.

Abstract: In some examples, a system is configured to determine, using a neural network algorithm of a cerebral autoregulation model, a cerebral autoregulation status of the patient based at least in part on a blood pressure of the patient over a period of time and regional cerebral oxygen saturation of the patient over the period of time.

Abstract: A system to automatically detect at least one physiological state is disclosed. The system includes a single probe for insertion within a subject that has an analyte sensor array for continuous monitoring of at least glucose and a second analyte. The system further includes an electronics module that includes a power supply, a processor, memory and a bi-directional communications module. When the electronics module is coupled with the analyte sensor array the power supply delivers power to the analyte sensor array and the processor. The processor analyzing glucose and the second analyte data to detect a first physiological state from a plurality of physiological states.

Abstract: A sensor assembly is disclosed. The sensor assembly includes a piercing member with an interior and exterior. Also included within the sensor assembly is a sensor that is formed on a flexible substrate. The sensor includes a proximal end and a distal end where the distal end includes a flex that is terminated at a terminal end. The terminal end of the sensor being located within the interior of the piercing member.

Abstract: A device for collecting blood from a mammalian subject without using spontaneous capillary blood flow, the device including a collection cup subassembly having a cantilevered, concave slide for transporting blood down and away from a blood sampling location; a mid-body subassembly couplable to the collection cup assembly and including a housing having a proximal end and a distal end and defining a plenum space; and a plunger subassembly having a first end and a second end and including a plunger formed at the second end and one or more lancet elements attached to the plunger. Advantageously, the plunger and lancet elements are structured and arranged to translate through the mid-body subassembly and the collection cup subassembly to the blood sampling location.

Abstract: An apparatus includes a housing that defines a fluid reservoir and includes a port that is in fluid communication with the fluid reservoir. An inlet adapter is removably coupleable to the housing. A user can engage an actuator to move a plunger from a first position in which the fluid reservoir has a first volume, to a second position in which the fluid reservoir has a second volume greater than the first volume, which draws bodily fluid into the fluid reservoir via the inlet adapter. The actuator modulates a plunger rate of motion below a threshold as the plunger is moved. When a predetermined volume of bodily fluid is transferred into the fluid reservoir, a volume indicator transitions from a first state to a second state and the inlet adapter can then be removed to transfer the predetermined volume into a sample bottle external to the housing via the port.

Abstract: A blood collection device including a distal end portion, a proximal end portion, an actuator, and a probe operably coupled to the actuator, wherein the actuator is configured to selectively advance the probe through a catheter of a vascular access device when the blood collection device is coupled to the vascular access device. The probe includes a distal portion and a proximal portion, wherein the distal portion and the proximal portion of the probe are formed of different materials, and wherein only the distal portion of the probe is configured to extend at least partially beyond a distal tip of the catheter of the vascular access device when the probe is in a fully advanced position.

Abstract: A disposable blood lancet device includes a barrel including a tubular barrel body; a tubular front slider inserted in the barrel; a carrier; a needle carrier; an actuation spring elastically pushing the needle carrier in the frontward direction; and a trigger portion coming into contact with the elastic transformation portion upon the rearward movement of the needle carrier and elastically transforming the elastic transformation portion inwards in the radial direction so that the interlocking holding projection can be separated inwards from the rear end of the front slider to propel the needle carrier frontwards.

Abstract: Systems and methods for autonomous intravenous needle insertion are disclosed herein. In an embodiment, a system for autonomous intravenous insertion include a robot arm, one or more sensors pivotally attached to the robot arm for gathering information about potential insertion sites in a subject arm, a medical device pivotally attached to the robot arm, and a controller in communication with the sensors and the robot arm, wherein the controller receives the information from the sensors about potential insertion sites, and the controller selects a target insertion site and directs the robot arm to insert the medical device into the target insertion site.

Abstract: A biological information processing device, a biological information processing system, and a biological information processing method which are capable of obtaining features of signals detected from a living body in real time are provided. The present technology provides a biological information processing device including an extraction unit that extracts a component signal corresponding to a physiological index from signals detected from a living body, and a variation emphasizing unit that changes the value of the component signal, based on a time constant when the value of the component signal varies, in which the variation emphasizing unit changes a value of a first component signal in accordance with a value of a second component signal having a time constant shorter than that of the first component signal of which the value is changed. The present technology also provides a biological information processing system and a biological information processing method.

Abstract: A device (1) for analysing a vehicle driver's perception of a danger comprises:—a heart rate sensor (10) designed to measure the driver's heart rate over time, and—a processing unit (40) designed to a) receive an indication (D) of the danger present in the environment of the vehicle, b) analyse the driver's heart rate measured by the heart rate sensor, during a time interval starting when the indication is received by the processing unit, and c) determine whether or not the danger has been perceived by the driver depending on whether or not the driver's heart rate analysed in step b) comprises a deceleration phase during the time interval.

Abstract: Described is a mood aggregation system. The system includes a server having a memory storing user information and a user computing device coupled to the server. The server may be programmed to automatically generate a mood request with response capabilities and send the request to the user computing device for display in response to the user computing device accessing the system. The server may also be programmed to receive and store mood data sent from the user computing device, wherein the mood data comprises a mood selection, a time the mood data was sent and a location of the user computing device when sending the mood data. The user may send a request for a report that is received and stored in the server for a user associated with the user computing device and automatically access the stored mood data and generate a report responsive to the report request.

Abstract: An arousal level control apparatus calculates a setting value of a control device under a constraint condition using an arousal level optimization model so that a value of an objective function is maximized. The control device affects a physical quantity of a surrounding environment that affects arousal level of a subject. The arousal level optimization model includes the constraint condition and the objective function. The constraint condition includes a physical quantity prediction model, an arousal level prediction model, and a setting value range condition that the setting value is within a predetermined range. The physical quantity prediction model is an explicit function that includes the physical quantity and the setting value as explanatory variables and has a predicted value of the physical quantity as an explained variable.

Abstract: An arousal level control apparatus calculates a setting value of a control device under a constraint condition using an arousal level optimization model so that a value of an objective function is maximized. The control device affects a physical quantity of a surrounding environment that affects arousal level of a subject. The arousal level optimization model includes the constraint condition and the objective function. The constraint condition includes a physical quantity prediction model, an arousal level prediction model, and a setting value range condition that the setting value is within a predetermined range. The physical quantity prediction model is an explicit function that includes the physical quantity and the setting value as explanatory variables and has a predicted value of the physical quantity as an explained variable.

Abstract: Provided herein are a variety of neural probe devices that include an agent delivery feature via an agent coating or an agent delivery mechanism of some kind. The probe devices can include depth or cortical probes or electrodes. The agent delivery mechanisms can include, for example, a dissolvable agent delivery structure, an agent delivery lumen, a magnetically deployable cover, an iontophoretic delivery mechanism, an agent delivery cavity defined in the neural probe, or an agent reservoir with an actuable gate.

Abstract: A diagnostic electrocardiogram (ECG) apparatus (20) is disclosed herein. The apparatus comprises a body and printed electrodes. The body (110) includes extension members (61-66), with each having an expansion section (61a) and at least one electrode section (61b). Each expansion section (61a) has at least one concertina member (75) and at least one connector member (76). The diagnostic ECG apparatus (20) conforms to American Heart Association guidelines on diagnostic resting ECGs.

Abstract: Techniques are provided that identify and localize on to reentrant and ectopic patterns of electrical activation in the heart wall. These patterns may correspond to atrial fibrillation, ventricular fibrillation, or other heart arrhythmia conditions. The techniques detect these patterns of electrical activity using a multi-lead an intra-cavitary catheter that, along with a controller, is able to track, over a multi-dimensional cubic space, reentrant activity and identify filaments in the heart cavity. The intra-cavitary catheter includes multiple conducting poles positioned in a configuration relative to each other and functioning as either or both sensing and active poles for measuring electrical pathways in the heart wall and over the multi-dimensional space.

Abstract: A neural recording apparatus including an electrode array including a plurality of electrodes configured to detect voltage signals of one or more neurons and a reference electrode configured to detect a reference signal, a regulator configured to regulate the reference signal, a plurality of transconductance circuits configured to generate current signals by performing transconductance based on the voltage signals and the regulated reference signal, a multiplexer (MUX) configured to multiplex on the generated current signals, and an analog-to-digital converter (ADC) configured to convert the multiplexed current signals into a digital signal

Abstract: Biometric data is measured by at least one remote monitoring device, and the biometric data includes electrocardiogram (ECG) data relating to a patient. The ECG data includes a plurality of critical rhythms, and one of the plurality of critical rhythms is identified as an onset event. The ECG data is modified, based on the identified onset event.

Abstract: Body-worn systems and methods for continuously monitoring a patient for cardiac electrical signals and identifying rhythm abnormalities including atrial fibrillation.

Abstract: Systems, apparatus, articles of manufacture, and methods are disclosed to detect a pace pulse in an electrocardiogram (ECG) signal. An example apparatus includes programmable circuitry configured to execute instructions to: identify a leading edge of a pulse in an input signal based on an amplitude change; identify a transition time of the leading edge of the pulse; validate the leading edge of the pulse based on the amplitude change and transition time; identify a trailing edge of the pulse; determine a width of the pulse between the leading edge and the trailing edge; and validate the pulse based on the width.

Abstract: A signal analysis device includes an analyzer that, upon approximating a time waveform of an R wave by a waveform obtained by a difference between a first cumulative distribution function and a second cumulative distribution function, acquires at least some of parameters identifying at least one of the first unimodal distribution, the first cumulative distribution function, the second unimodal distribution, or the second cumulative distribution function, upon approximating a waveform obtained by reversing a time axis of a time waveform of a T wave by a waveform obtained by a difference between a third cumulative distribution function and a fourth cumulative distribution function, acquires at least some of parameters identifying at least one of the third unimodal distribution, the third cumulative distribution function, the fourth unimodal distribution, or the fourth cumulative distribution function, and acquires a parameter indicating activity of a myocardium of the heart by calculating acquired parameters.

Abstract: A method for health monitoring is provided including at least one non-invasive wearable device capable of collecting and storing data, and external monitoring devices that displays and analyses the data for accurate monitoring and anomaly detection. The wearable devices are configured to collect low-latency PPG-derived bio signals and can utilize multiple devices for accuracy and continuity. The system may further include a dashboard that analyzes the information as well as displaying basic information such as number of beds (in-use, available), staff-to-patient ratio, etc. The data can be collected and accessed remotely and may be utilized before, during, and/or after a patient is dispatched from a clinical setting.

Abstract: A plurality of sensors detect neural activity and/or muscle activity of a person. A display renders an image with an avatar that represents the person. A processor moves a portion of the avatar in response to calculations performed on signals corresponding to the neural activity and the muscle activity. The avatar may be caused to move in a manner corresponding to an expected muscle movement of the person. However, due to illness or disease, the person may be unable to fully execute the expected muscle movement. By watching the avatar move in response to efforts to execute an expected muscle movement, the person may train his or her body to more fully execute desired muscle movements, such as through neurofeedback for rehabilitation.

Abstract: A system for evaluating neurologic dysfunction of a subject includes an odorant generator configured to deliver an odorant stimulation to the subject, an auditory generator configured to deliver an audible stimulation to the subject, a vibrotactile stimulator configured to generate a somatosensory stimulation to the subject, a plurality of electrodes configured to be attached to the subject at respective different locations, and at least one processor. The plurality of electrodes are configured to collect neural signals from the subject as a result of the odorant stimulation, the audible stimulation, and the somatosensory stimulation. The at least one processor is configured to process the neural signals from the plurality of electrodes and generate an assessment of neurologic dysfunction of the subject.

Abstract: Embodiments of a method for removal and replacement of artifacts in electrophysiological data from muscular activity in the gastrointestinal tract of a patient are disclosed. The approach includes setting an artifact identification threshold based on the parameters of the data, assessing the full extent of the artifact in time, and replacing the values with ones that are neutral in the time series and minimizing the effect on a power spectrum of the data. More particularly, the method includes steps of identifying artifacts within the raw time series data, eliminating the identified artifacts, and replacing the artifacts with any of interpolated points or constant value points to create a clean time series data set representing valid gastrointestinal tract EMG signals.

Abstract: A monitoring system may include a processor and display system for displaying results from the monitoring. A user may be in a sterile field away from the processor and display system and selected input devices. The processor may execute instructions to analyze a selected signal and, if selected, display the analysis.

Abstract: A sensor including electrodes, a control module and a physical layer module. The electrodes are configured to (i) attach to a patient, and (ii) receive a first electromyographic signal from the patient. The control module is connected to the electrodes. The control module is configured to (i) detect the first electromyographic signal, and (ii) generate a first voltage signal. The physical layer module is configured to: receive a payload request from a console interface module or a nerve integrity monitoring device; and based on the payload request, (i) upconvert the first voltage signal to a first radio frequency signal, and (ii) wirelessly transmit the first radio frequency signal from the sensor to the console interface module or the nerve integrity monitoring device.

Abstract: A system for detecting a cognitive status of a driver of a vehicle includes a first sensor configured to detect vehicle performance data, a second sensor configured to detect driver condition data, and an electrical control unit (ECU) coupled to the first sensor and the second sensor. The ECU is configured to receive the vehicle performance data corresponding to the cognitive status of the driver, receive the driver condition data corresponding to the cognitive status of the driver, and transmit the vehicle performance data and the driver condition data to a remote device.

Abstract: The present invention provides a method for extracting a neuroimaging biomarker based on an interpretable ensemble three-dimensional convolutional neural network (3DCNN) to address limitations in the prior art. The present invention derives a novel neuroimaging biomarker P-score from prediction results obtained by an ensemble three-dimensional convolutional neural network model. The solution can help researchers to conduct studies on longitudinal trajectory changes of structural magnetic resonance imaging (sMRI) during the progression of Alzheimer's disease, and analyze an association of the longitudinal trajectory changes with neurodegenerative changes of Alzheimer's disease subjects. The extracted neuroimaging biomarker can provide a basis for predicting a sequence of intervention of brain regions in the neurodegenerative changes of Alzheimer's disease patients and upcoming clinical symptoms.

Abstract: A system and method for finding a Pareto-optimal solution for automated detection, warning, and abatement of a medical condition based on a cost of event intervention in a patient is disclosed. The method includes acquiring at least one biological signal from the patient via at least one sensor of a medical device, detecting an abnormal biological event based on changes in the biological signal, and delivering at least one of a therapy and a warning. The method includes logging a set of parameters including at least one of a detection parameter, a therapy parameter, and a therapy modality. The method includes finding an optimal set of parameters that yield a Pareto-optimal cost of event intervention by iteratively determining at least one metric over a time window, determining the cost of event intervention, and modifying at least one parameter, until the cost of event intervention meets an acceptability criteria.

Abstract: The invention provides an article for detecting amniotic fluid, comprising a membrane layer, a transfer layer, an absorbent layer, and a base layer, wherein the transfer layer comprises an indicator composition. Further provided are methods of use of the article for obtaining an immediate, clear, and reliable identification of amniotic fluid leakage.

Abstract: Internal cervical exams during labor pose multiple challenges, including infection risk, subjectivity, invasiveness, and discomfort. A monitoring system described herein enables non-invasive and accurate measurement of cervical dilation and assessment of the baby's station. By inserting a narrow linear ultrasound probe through the working channel, high-resolution ultrasound images of the cervix can be obtained, eliminating the need for painful and subjective exams, reducing infection risk, and enhancing patient comfort. Moreover, the ultrasound capability allows for potential monitoring of maternal and fetal blood oxygenation levels, providing a comprehensive picture of fetal well-being.

Abstract: Methods of assessing the pathological and/or physiological state of a subject, methods of monitoring a subject with heart failure or a subject that has been diagnosed as having or being at risk of having a condition associated with dyspnea and/or fatigue, and methods of diagnosing a subject as having decompensated heart failure are provided. The methods comprise obtaining a voice recording from a word-reading test from the subject, wherein the voice recording is from a word-reading test comprising reading a sequence of words drawn from a set of n words and analysing the voice recording, or a portion thereof.

Abstract: Approaches described herein can capture an audio signal using at least one microphone while a user of an electronic device is determined to be asleep. At least one audio frame can be determined from the audio signal. The at least one audio frame represents a spectrum of frequencies detected by the at least one microphone over some period of time. One or more sounds associated with the at least one audio frame can be determined. Sleep-related information can be generated. The information identifies the one or more sounds as potential sources of sleep disruption.

Abstract: Provided herein are systems and methods for monitoring one or more health or physiological parameters in a subject. The systems and methods may comprise a patch coupled to an injector. Data may be transmitted to a mobile device or remote server, where the data may be processed. Processed data may be used to inform a subject on a health or physiological condition.

Abstract: Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve. The methods include evaluating a change in physiological parameters after energy is delivered to an arterial wall; and determining the type of nerve that the energy was directed to (sympathetic or parasympathetic or none) based on the evaluated results. The system includes at least a device for delivering energy to the wall of blood vessel; sensors for detecting physiological signals from a subject; and indicators to display results obtained using said method. Also provided are catheters for performing the mapping and ablating functions.

Abstract: A method includes obtaining test criteria for a monitor configured to be attached to a user; obtaining reference data; determining, based on the test criteria and the reference data, a detached state of the monitor. The determining the detached state includes performing a set of tests indicated in the test criteria. The set of tests includes a first test corresponding to a first power consumption by the monitor; and a second test different from the first test. The second test corresponds to a second power consumption by the monitor, and the second power consumption is larger than the first power consumption. The method further includes automatically modifying, in response to the determining the detached state, an operating mode of the monitor.