Abstract: A diffuser made of thermoform molded pulp in a desired shape, such as a hanging ornament, having features to secure a wicking part of the diffuser to a rounded bottle opening filled with an oil fragrance. To insert the diffuser, a cap is unscrewed from a bottle filled with oil fragrance, and the wicking part is inserted through the opening of the bottle until it rests on the interior bottom of the bottle. A rotatable capping feature is featured at the top of the wicking part, which is closed during insertion of the wicking part to prevent accidental spillage and loss oil due to evaporation. The wicking element draws the oil fragrance into the ornamental diffusing part by capillary action.

Abstract: The invention describes a method and a walk through apparatus to treat surfaces with hydroxyl ions to reduce the viability and/or kill pathogens.

Abstract: Provided is a method of protection treatment in a target space where inactivation of bacteria and/or viruses is performed. The target space is a space where a light source emitting ultraviolet light having light output in a specific wavelength band belonging to within a range from 190 nm to 235 nm has already been disposed or is planned to be disposed. The method of protection treatment includes the steps of attaching a base material whose main component is a chlorine-based resin, to an interior surface of the target space or a surface of an object disposed in the target space, and forming a protective layer on a surface of the base material. The protective layer contains a material that exhibits resistance to the ultraviolet light.

Abstract: The present disclosure provides a hydrophilic fiber membrane with a sustained-release drug, and belongs to the field of biological materials. The present disclosure provides a hydrophilic fiber membrane with a sustained-release drug, including a fiber with a core-shell structure, where a core of the fiber includes curcumin and a first spinnable polymer, and a shell of the fiber includes polyethylene glycol and a second spinnable polymer; and in the shell, the polyethylene glycol and the second spinnable polymer have a mass ratio of not greater than 1:12. In the present disclosure, the fiber membrane has a core-shell structure, the curcumin is provided in the core, and the shell prevents a rapid release of the curcumin in an early stage, thereby delaying a release rate of the curcumin to prevent the drug from forming a burst release in the early stage and causing toxic reactions.

Abstract: The invention relates to biodegradable bilayer sealants for tissue closure. The sealants of the invention are composed of two layers with different compliances. The layer in immediate contact with the tissue has high compliance. The second layer located immediately above the first sealant layer has low compliance, i.e. the sealant is much stiffer. The burst pressure of the bilayer sealants is enhanced relative to either a single layer elastic sealant or a single layer stiff sealant. The improved sealant compositions herein provide a water-tight seal, can access hard to reach tears, be applied in a dry or wet environment, are low-swelling, and can repair a range of incision or tear sizes. The bilayer sealants are particularly useful for sutureless dural closure or as adjuncts to sutured dural closure. Also provided herein are methods of preparing and using the biodegradable sealant compositions.

Abstract: The present invention relates to a wound dressing comprising hyaluronic acid-calcium and polylysine, and a manufacturing method therefor, the method comprising: (1) a step for adjusting each of the pH values of a hyaluronic acid-calcium salt and a polylysine aqueous solution to 8.4 or higher, and then mixing the hyaluronic acid-calcium salt and the polylysine aqueous solution to obtain a mixture liquid; and (2) obtaining a wound dressing from the mixture liquid obtained in Step (1).

Abstract: Described herein are therapeutic compositions comprising a wound healing agent such as keratin, and a bitterant, that can be used for skin care applications or to treat and heal wounds in veterinary medicine while preventing licking without the use of an Elizabethan collar.

Abstract: A viscoelastic composition is disclosed which comprises (a) tris(hydroxymethyl)aminomethane or a salt thereof; (b) a phosphate buffer agent; and (c) a viscoelastic agent having an average molecular weight of about 100 to about 5,000,000.

Abstract: The present disclosure provides a fiber membrane and a preparation method and use thereof, and belongs to the field of biological materials. The fiber membrane includes a fiber with a core-shell structure, where a core of the fiber includes simvastatin and a first spinnable polymer, and a shell of the fiber includes hydroxyapatite and a second spinnable polymer. In the fiber, a release of the simvastatin mainly depends on a rate of water invasion. After water invades the fiber, the simvastatin in the fiber leaves the fiber with the diffusion of water. In the present disclosure, a barrier function of the shell prevents moisture from entering the core. Therefore, the simvastatin in the core cannot leave the fiber with the diffusion of water molecules in an early stage, and a release rate of drugs is slowed down in the early stage, thereby controlling sustained release of the drugs.

Abstract: A wet human or other tissue product may be packaged with a primary and secondary backing. The primary backing may cover a larger area of the tissue than the secondary backing, and the primary backing may be removed first during application of the tissue to a patient, either by sliding or peeling the primary backing away. The secondary backing may assist in holding the tissue in place while the primary backing is removed. The primary backing may provide mechanical support and keep the tissue spread during packaging, handling, and application to a patient. The tissue assembly with primary and secondary backing may be stored in a heat sealed, sterile flat pouch with preservation media. The packaged assembly may include a port for introducing preservation media. A use case for the packaging includes wet, undried amniotic membrane.

Abstract: The present disclosure relates to a bone graft composition, and more particularly, to a bone graft composition including: a bone graft material; a thickener having an adhesive property; and hydroxypropyl methylcellulose as a crosslinker that forms a bond with each of the bone graft material and the thickener.

Abstract: Compositions and methods for modular fabrication of large, three-dimensional, perfusable networks of vascularized tissue are provided. Each layer within the tissue may include the same or different cell types and have the same or different types of vasculature. In some aspects layers of tissue together form the large, three-dimensional perfusable networks as each layer contains a portion of the larger tissue and the combination of the various layers creates a tertiary structure of integrated perfusable networks that exhibit remodeling and evenly distributed perfusion among layers while maintaining a patterned open-lumen architecture.

Abstract: The disclosure provides tubes comprising ultra high molecular weight poly(ethylene) (UHMWPE). Such tubes can have thin walls and be suitable for applications, e.g., as catheter liners. Methods for preparing such tubes include dip coating a core into a dispersion comprising the UHMWPE, where the dispersion advantageously further comprises an eco-friendly solvent and can optionally include one or more additional components (e.g., fillers and/or other polymers).

Abstract: A radiopaque lined heat shrinkable tubing is disclosed. A non-limiting example of a radiopaque lined heat shrinkable tubing is a multilayer construction having an inner layer and an outer layer, wherein the inner layer includes a thermoplastic that is highly loaded with a radiopaque filler, and the outer layer includes a fluoropolymer heat shrink tube.

Abstract: A biologic stent or conduit made from an umbilical cord has a tissue body structure having a fluid passageway configured to be open to pass bodily fluids from a first end through a second end. The tissue body structure has an internal surface defining a boundary interior wall of the open fluid passageway and an external surface defining an exterior wall of the tissue body structure. The tissue body structure is made semi-rigid or rigid to maintain the stent or conduit open during the implantation and securing of the tissue body structure into the vessel, duct, or bowel. After a predetermined time sufficient to suture or otherwise fix the ends of the stent or conduit, the tissue body structure softens to a conformable stent inside the vessel duct, or bowel being repaired or reinforced.

Abstract: Disclosed is a high anticoagulation extracorporeal circulation tube, which include the following preparation methods: S1, firstly, aminating the surface of the tube by extrusion molding; S2, activating heparin groups by a direct coupling method; S3, heparinizing PVC or PC tubes; S4, then, using albumin, functionalized PEG which can react with amino groups, and phosphate to further surface modify the inner wall of heparinized PVC or PC tube to block the sites not modified by heparinization, so as to shield the adsorption of platelets and protein in blood on the inner wall. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.

Abstract: A method and system for donating blood and/or blood components is disclosed. The method and system include at least one adjustment mechanism to alter at least one feature of a blood draw in order to minimize and/or prevent donor reactions.

Abstract: A breast milk pump bottle securing device for encasing a bottle and securing to a breast milk pump includes a sleeve enwrapping a bottle for breast milk. The sleeve has an exterior surface and an interior surface. Furthermore, the sleeve has an open end and a base end. A base is positioned on the base end, thus the base and the interior surface of the sleeve enclose an interior. A strap is positioned on a perimeter of the open end of the sleeve and extends out from the open end. The strap has a button end, and the button end has a button. The strap is folds over a top of a breast milk pump. A clasp is positioned on the exterior surface of the sleeve. The clasp is engages by snap button fastening to the button.

Abstract: An in-bra wearable breast pump is provided. The breast pump includes an air pump system for generating a base level vacuum and a pumping vacuum, a breast shield for receiving a user's breast and having a first side and a second side, a first channel for drawing the base level vacuum on the first side of the breast shield, and a second channel for drawing the pumping vacuum on the second side of the breast shield.

Abstract: A wearable leak-proof breast suction device is provided. The breast suction device includes a breast suction device body. A breast suction cover is disposed on the breast suction device body. A sucker is disposed on a central bulging part of the breast suction cover, and a central depression part of the sucker has a through hole connected to a three-way member of the breast suction device body. The sucker covers a breast when the breast suction device body is in operation. A connecting pipe is disposed between the sucker and the breast suction cover, and is connected to a through hole and extends in a direction toward the three-way member. Each of the connecting pipe, the sucker and the breast suction cover is flexible. An inner edge of the connecting pipe is curved at a connection with an edge of the through hole of the sucker.

Abstract: A breast pump or milk collection assembly comprises a rear assembly for fitting over the breast of a user, a front assembly for fitting over the rear assembly and a milk container for fitting beneath the rear and front assemblies. The rear assembly comprises all parts (other than the container) which will contact milk in use, such as a breast shield and a diaphragm. The front assembly comprises all parts which do not need cleaning, for example a cover for fitting over the diaphragm to define a sealed space between them, a power source, pump and controller, and a front cover. A release element which projects forwards along a channel in the front assembly, thereby to define a release actuator at an external face of the front assembly for releasing the coupling together of the rear and front assemblies.

Abstract: An example vacuum motor device for facilitating milk extraction from a breast of a user can include: a first chamber; a second chamber coupled to the first chamber; and a voice coil motor configured to cause air to flow into the second chamber and out of the first chamber during a breast pumping cycle to create suction for extracting the milk.

Abstract: A peritoneal dialysis system comprises a cycler including a dialysis fluid pump, a plurality of valve actuators, and a control unit configured to control the dialysis fluid pump and the plurality of valve actuators; and a drain line including a disposable portion, a reusable portion, and a drip chamber located between the disposable portion and the reusable portion, the drip chamber configured to create an air column that dissuades pathogen migration from the reusable portion to the disposable portion. The dialysis fluid pump may include a pneumatic valve manifold and an air pump positioned and arranged to supply pneumatic pressure to the pneumatic valve manifold. The disposable portion of the drain line may be provided as part of a disposable set including a pump actuation portion operable with the dialysis fluid pump, and a valve actuation portion operable with the plurality of valve actuators.

Abstract: A pumping cassette including a housing having at least two inlet fluid lines and at least two outlet fluid lines. At least one balancing pod within the housing and in fluid connection with the fluid paths. The balancing pod balances the flow of a first fluid and the flow of a second fluid such that the volume of the first fluid equals the volume of the second fluid. The balancing pod also includes a membrane that forms two balancing chambers. Also included in the cassette is at least two reciprocating pressure displacement membrane pumps. The pumps are within the housing and they pump the fluid from a fluid inlet to a fluid outlet line and pump the second fluid from a fluid inlet to a fluid outlet.

Abstract: A peritoneal dialysis system includes a cycler having a pneumatic valve manifold, an air pump positioned and arranged to supply pneumatic pressure to the pneumatic valve manifold without intervening pneumatic storage, a pneumatic pressure sensor positioned and arranged to detect pneumatic pressure, and a control unit configured to use an output of the pressure sensor as feedback to adjust the air pump according to a set pneumatic pressure; and a disposable set including a pod pump having a flexible sheet, one side of the flexible sheet positioned and arranged during operation to receive pneumatic pressure via the air pump and pneumatic valve manifold.

Abstract: A blood filtration system may include one or more sensors. The sensors may determine physiological parameters, for instance one or more of venous oxygen saturation (Sv02) or hematocrit of a patient. The blood filtration system may include a controller. The controller may communicate with the one or more sensors. The controller may monitor the physiological parameters using the sensors. The controller may include a display module that generates content. A display may present the content. The content may include a diagnostic matrix having a diagnostic point. The display module may change the diagnostic point within the diagnostic matrix according to changes in the monitored physiological parameters.

Abstract: An artificial diuresis device wearable by a patient can include a reusable machine and a disposable unit; wherein said disposable unit is completely filled, before use, with treatment liquid.

Abstract: Disclosed is a high anticoagulation ECMO and extracorporeal circulation consumable, which include the following preparation methods: S1, aminating the surface of ECMO blood circulation device and extracorporeal circulation consumables; S2, activating heparin groups; S3, heparinizing the ECMO blood circulation device and extracorporeal circulation consumables; S4, modification of enhancer. The application can produce a novel high anticoagulation extracorporeal circulation tube with low price and high biocompatibility, which expands the application in clinic.

Abstract: A fluid source management system (100) comprising a structure (101) that supports one or more fluid sources (103), sensors (102) that determine the fluid state of the fluid sources (103), at least one common reservoir (108) for storing the fluid, tubing (104) connecting the fluid sources (103) to the common fluid reservoir (108) and a controller (105) that controls the opening and closing of the tubing (104) based upon the fluid state of the fluid sources (103).

Abstract: An ear cleaning device relating to a technology of medical auxiliary equipment is provided, the ear cleaning device includes a bottle body, a spray assembly, and a temperature display assembly arranged on the bottle body. The temperature display assembly includes a temperature sensor and a display screen electrically connected with the temperature sensor, The temperature sensor is arranged in the bottle body and is configured to detect temperature of liquid in the bottle body, and the display screen is configured to display the temperature. The spray assembly is connected to a nozzle and a straw, and the straw extends into the bottle body. The ear cleaning device displays the temperature of the current liquid in real time, which facilitates the control of the temperature of the liquid during a washing process.

Abstract: A transportation tray to transport filled syringes, the tray including a front shelf spaced apart from a rear shelf, with the front shelf and the rear shelf being on approximately the same plane. The front shelf includes at least one set of paired flexible fingers, the paired flexible fingers being spaced apart sufficiently to accommodate a barrel of a syringe and to thus hold the syringe on the tray.

Abstract: The present disclosure provides a CT device and a method for controlling a CT device. The CT device includes a CT gantry and at least one infusion clip. The CT gantry includes a first end cover and a second end cover opposite to each other. Either or both of a surface of the first end cover and a surface of the second end cover is provided with a guiding rail. One end of each infusion clip is connected to one guiding rail and is slidable along the guiding rail, and the other end of the infusion clip is configured to position an infusion assembly.

Abstract: A drug delivery device includes a housing, a container disposed in the housing, an activation mechanism, a needle assembly, and a temperature indicator. The housing defines an inner volume and includes at least one opening. The container contains a medicament which is urged out of the container by the activation mechanism. The needle assembly has a needle and/or a cannula to deliver the medicament from the container. The temperature indicator is operably coupled with the outer surface of the container and is responsive to a change in temperature of the container.

Abstract: A method and system for delivering partial boluses using infusion pumps is disclosed. An example method includes storing a programmed dose volume to be administered in response to a request from a patient and instructing the pump to begin dispensing the programmed dose volume of fluid from the fluid supply. The method further includes receiving an indication that the pump has stopped pumping, determining a partial dose volume, and when the partial dose volume equals a value greater than zero, generate an alarm that the fluid supply is depleted. Additionally, the method includes exchanging the depleted fluid supply with a subsequent fluid supply, dispensing from the subsequent fluid supply the partial dose volume, and preventing any subsequent dispensing of fluid from the subsequent fluid supply for a programed lockout period.

Abstract: This document discusses, among other things, an apparatus comprising a pump configured to deliver a fluid, a wireless communication port, a controller, and a housing to enclose the apparatus. The controller is configured to communicate with a second device via the communication port using an open standard wireless communication protocol. The housing includes a mechanical coupling to slidably engage the second device which includes a second wireless communication port. Slidably engaging the second device positions the first and second communication ports opposite each other to allow communication via the first and second communication ports when slidably engaged.

Abstract: An improved system, method for an infusion pump is an electronic computerized device that allows to precisely time and dose intravenous or enteral therapy. The proposed infusion pump system increases patient comfort and convenience, while it is lightweight and modular. It comes with a user-friendly interface using onboard buttons and through an associated application, multiple types of controls can be practiced by the user through his/her smart device.

Abstract: An integrated skin patch artificial pancreas includes an infusion mechanism module, including a case, provided with multiple second electrical contacts exposed on the case and multiple second engaging portions; a control mechanism module, provided with multiple first electrical contacts exposed on the surface of the control mechanism module and multiple first engaging portions, the control mechanism module including an input end and an output end, and the input end including electrically connective regions for receiving signals of analyte data in the body fluid and an infusion tube (150), provided with multiple electrodes.

Abstract: A skin patch drug infusion device is provided. The device includes an infusion mechanism module, a control mechanism module and an adhesive patch. The infusion mechanism module includes an infusion module and a circuit module. The circuit module includes: a circuit board or a three-dimensional circuit coated on the surface of part components, for supplying power to specific units; a driving unit, for pushing the driving wheel of the infusion mechanism module to implement drug infusion; a conductive tower-spring, including a middle part with a small diameter and two end parts with a large diameter in the axial direction, for fixing the driving unit and electrically connecting the driving unit and the specific connection end on the circuit board or three-dimensional circuit. The control mechanism module is electrically connected with the infusion mechanism module. The adhesive patch is used for attaching the infusion mechanism module and the control mechanism module to the skin surface.

Abstract: A skin patch drug infusion device includes an infusion mechanism module, the infusion mechanism module includes an infusion module and a circuit module, the circuit module includes: a circuit board or a three-dimensional circuit coated on the surface of part components, for supplying power to specific units; a power unit, for providing power to pull the driving wheel of the infusion mechanism module to implement drug infusion; a conductive platform, provided with a conductive platform protrusion, for electrically connecting the power unit to the specific connection end on the circuit board or three-dimensional circuit; a control mechanism module, electrically connected with the infusion mechanism module; and an adhesive patch, for attaching the infusion mechanism module and the control mechanism module to the skin surface.

Abstract: Disclosed are techniques, devices and systems that modify an insulin delivery schedule based on how sensitive a diabetic user may to fluctuations in their total daily insulin or fluctuations in their blood glucose measurement values. As a control algorithm calculates how to adapt the calculation of the user's total daily insulin, a rate of adaptivity function may be used in the calculation. The rate of adaptivity may depend on a number of factors and the disclosed techniques, devices and systems enable calculation of the rate of adaptivity to provide effective implementation or modification of a diabetic treatment plan.

Abstract: A method of dispensing a therapeutic fluid from a line includes providing an inlet line connectable to an upstream fluid source. The inlet line is in downstream fluid communication with a pumping chamber. The pumping chamber has a pump outlet. The method also includes actuating a force application assembly so as to restrict retrograde flow of fluid through the inlet while pressurizing the pumping chamber to urge flow through the pump outlet. A corresponding system employs the method.

Abstract: A drug delivery device for delivering a medicament includes a pump first housing, a pump second housing, an inlet fluid path, and an outlet fluid path. The pump first housing is at least partially supporting and/or surrounding a fluid displacement assembly. The pump second housing is at least partially supporting and/or surrounding a drive component for driving the fluid displacement assembly. The inlet fluid path is configured to deliver medicament to the fluid displacement assembly. The outlet fluid path is configured to receive medicament from the fluid displacement assembly. The pump first housing and the pump second housing are removably coupled with each other.

Abstract: A fluid delivery device has a syringe barrel with reservoir chamber for fluid, a plunger that translates along a longitudinal axis to expel fluid, and a pusher dimensioned to translate within the barrel and coupled to a drive mechanism to controllably contact and move the plunger. The pusher contacts the plunger at its mechanical center to reduce tilt in the plunger. Contact faces of the pusher and plunger cooperate as a ball joint to minimize non-axial forces on the plunger face. The pusher can have a protrusion of various lengths extending toward and being at least partially received in a recess of various depths in the plunger. The pusher is rigidly connected to a drive mechanism for anti-rotation. The pusher can have scalloped edges for air venting, and apertures for cooperating with protrusions on the drive mechanism to prevent bottoming out the plunger when filling.

Abstract: A care assembly placement system may comprise an inserter including a port with a coupling interface and a receptacle body including tracks partially swept around the axis of the port. The system may further comprise a cartridge including a retainer with a care assembly coupled thereto and a sharp holder having a first end bearing a sharp. The retainer may include projections. The sharp holder may include a coupling interface opposite the first end. When the cartridge is placed in an aligned position relative the receptacle body and rotated to a coupled state, the projections may each displace along a ramp of a respective track in a first displacement range translationally driving the cartridge to a position in which sharp holder and port coupling interfaces are aligned. The sharp holder coupling interface may be rotated into engagement with the port coupling interface in a second displacement range of the cartridge.

Abstract: Disclosed herein are various embodiments of a location data processing system. An embodiment operates by configuring a column of a table to store data across a plurality of different coordinate systems. The data to be stored in the configured column is received. The received data is divided into a plurality of fragments, including a first fragment comprising a plurality of data entries. A first data entry in the first fragment includes a coordinate specification including metadata indicating how to evaluate corresponding data of a first coordinate system represented by the first data entry. A query for data from the first fragment is received. The plurality of data entries of the first fragment are evaluated based on the coordinate specification to identify data that satisfies the query. The data is returned responsive to the query.

Abstract: A fluid management and medical device system may include a fluid management system and a medical device having one or more sensors proximate the distal end of the elongate shaft of the medical device. The controller of the fluid management system may be configured to calculate a fluid deficit when the distal end of the elongate shaft is disposed within a patient and configured to automatically pause fluid deficit calculation when the distal end of the elongate shaft is removed from the patient. In some instances the controller is configured to calculate the fluid deficit using rotational speed of the inflow pump in combination with a difference between a change in weight of a fluid supply source supplying fluid to the fluid management system and a change in weight of a collection container collecting fluid from the fluid management system.

Abstract: Some embodiments are directed to a medical device for fluidly connecting to a medical spike, including a spike port configured to receive therein the medical spike and establish fluid communication between the medical spike and the medical device. The spike-locking mechanism can be configured to resist extraction of the medical spike from the spike port.

Abstract: A device for monitoring bolus doses of a medicament administered by a drug delivery device, such as a wearable infusion device, includes a housing and a sensor disposed therein, where the sensor detects a signal generated by the wearable infusion device upon administration of a dose of a medicament. The device may also be provided as a system with the drug delivery device and a user device, where the user device gathers data regarding use of the drug delivery device and doses of medicament administered.

Abstract: A drug infusion device with embedded power supply includes a drug reservoir, used for accommodating the drug to be infused, provided with a piston and a screw; a driving wheel, connected with the screw, driving the screw to push the piston forward by rotation; a power supply, used to supply power to the infusion device, including a power supply shell, a battery cell, electrolyte and a cover plate; a frame, used to carry the drug reservoir, the driving wheel, the power supply and electrical connection terminals of specific components, the power supply is electrically connected to the electrical connection terminals of specific components to realize power supply to the infusion device; a case, including an upper case and a lower case, for accommodating the drug reservoir, the driving wheel, the power supply and frame.

Abstract: Automatic suspension and resumption of medicament delivery is described. In one or more implementations, a request to suspend delivery of a medicament to a user is received. A medicament delivery system is controlled to suspend delivery of the medicament to the user, and to automatically resume medicament delivery to the user after a suspension time period. In one or more implementations, a medicament delivery system is controlled to suspend delivery of a medicament to a user during performance of an activity, and to automatically resume delivery of the medicament to the user after performance of the activity is completed. In one or more implementations, a medicament delivery system is controlled to suspend medicament delivery to a user at a first time based on a location of the user, and to resume medicament delivery to the user at a second time based on a subsequent location of the user.