Abstract: An electrosurgical system having an ultrasound generator, configured to emit a high-frequency electrical signal, and an ultrasound instrument, including an ultrasound transducer configured to convert the signal into an ultrasound oscillation, wherein the generator is further configured to determine a resonance frequency of the transducer and adapt a frequency of the signal to the resonance frequency, and wherein the generator is further configured to detect a phase position between the current and the voltage of the signal and based on the detected phase position to determine whether the frequency of the signal corresponds to the resonance frequency. To enable the resonance frequency of the transducer to be determined correctly irrespective of component tolerances, the electrosurgical system is characterized in that the generator is configured to consider, during determination of the phase position, correction values, which are or can be stored in a memory of the generator and/or of the instrument.

Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

Abstract: An electrosurgical instrument comprising a housing, a shaft extending from the housing, an end effector extending from the shaft, an articulation joint rotatably connecting the end effector to the shaft, and a wiring circuit is disclosed. The housing comprises a printed control board. The wiring circuit extends from the printed control board through the shaft and into the end effector. The wiring circuit is configured to monitor a function of the end effector and communicate the monitored function to the printed control board. The wiring circuit comprises a proximal rigid portion fixed to the shaft, a distal rigid portion fixed to the end effector, and an intermediate portion extending from the proximal rigid portion to the distal rigid portion. The intermediate portion comprises a resilient portion and a stretchable portion.

Abstract: A surgical instrument includes a housing and an elongated shaft operably coupled to an actuating mechanism moveable between an actuated position and an unactuated position. An end effector includes a pair of opposing first and second jaw members. One or more drive surfaces are disposed on the actuating mechanism and configured to compress a spring upon movement of the actuating mechanism to the actuated position. The spring imparts a spring force in a distal direction to bias the actuating mechanism to the unactuated position. An electrically conductive tissue sealing surface extends along a length of one or both of the jaw members and is adapted to connect to a source of electrosurgical energy.

Abstract: In one embodiment, a catheter apparatus is configured to be inserted into a body part of a living subject, and including an elongated deflectable element including a distal end, an expandable basket assembly disposed at the distal end and comprising a plurality of splines and a plurality of electrodes disposed on the splines, an irrigation channel disposed in the elongated deflectable element, and an inflatable balloon disposed in the expandable basket assembly and including a plurality of irrigation holes in fluid connection with the irrigation channel.

Abstract: Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Abstract: A microwave ablation catheter assembly is provided. A coaxial cable configured to connect to a microwave energy source at its proximal end and at its distal end to a distal radiating section. The coaxial cable includes inner and outer conductors and a dielectric positioned therebetween. An extended working channel is configured to receive the coaxial cable for positioning the coaxial cable adjacent target tissue. At least a portion of an inner surface of the extended working channel is electrically conductive. The electrically conductive inner surface of the extended working channel may function as a balun to maintain a balanced signal between the inner and outer conductors of the coaxial cable when the distal radiating section of the coaxial cable is energized.

Abstract: An ophthalmologic information processing apparatus according to the embodiments include a generator, an extractor, and a phase correction unit. The generator is configured to generate a phase difference profile by performing averaging processing in a depth direction on phase differences obtained by calculating for each depth position of A-lines between two adjacent B-frames of complex OCT data of a subject's eye. The extractor is configured to a phase drift from the phase difference profile generated by the generator. The phase correction unit is configured to correct a phase of first complex OCT data of any one of the two B-frames based on the phase drift extracted by the extractor.

Abstract: An OCT system for measuring a retina as part of an eye health monitoring and diagnosis system. The OCT system includes an OCT interferometer, where the interferometer comprises a light source or measurement beam and a scanner for moving the beam on the retina of a patient's eye, and a processor configured to execute instructions to cause the scanner to move the measurement beam on the retina in a scan pattern. Measurement data may be processed using a decurving process to enhance the resolution of the ILM layer and provide improved determinations of retinal thickness.

Abstract: Provided is a diagnosis system for anterior eye diseases. An image obtainer obtains an anterior eye image of an image obtainer configured to obtain an anterior eye image of a subject. A characteristic extractor extracts characteristic information of the obtained anterior eye image on the basis of a machine-learning model. A disease analyzer determines whether or not an anterior eye of the subject has a disease and classifying a disease class according to the extracted characteristic information.

Abstract: A non-mydriatic, non-contact ultra-widefield fundus (u-WF) photographic imaging system and method are provided for performing u-WF photographic imaging of the eye. The non-mydriatic, non-contact u-WF photographic imaging system includes an illumination system that delivers trans-pars-planar illumination to the eyeball. This frees the entire pupil to be used for imaging. Freeing the entire pupil to be used for imaging allows a u-WFC of the non-mydriatic, non-contact u-WF photographic imaging system to use a relatively simple optics system to capture an ultra-wide FOV. Eliminating the need to dilate the pupil and the need to make contact with the eye while performing imaging eliminates the many problems associated with mydriatic, contact-mode fundus imaging systems and methods. In addition, the system can be implemented in a way that makes it highly suitable for telemedicine applications in underserved areas where clinics and trained healthcare providers may not be available.

Abstract: An imaging system for generating an image of a region of an eye, comprising: an ocular imaging device controlled by a control module to acquire, from a first viewpoint, a first ocular image of the region having an image artefact caused by obstruction from imaging of a part of the region by an object, and a second ocular image from a predetermined second viewpoint, which shows at least a portion of the part of the region that was obstructed from imaging during acquisition of the first ocular image; and an image data processing module for combining the first and second ocular images to generate an enhanced ocular image having an image artefact caused by obstruction from imaging by the object which is smaller in relation to the image artefact in the first or second ocular image, or no such image artefact.

Abstract: This disclosure describes systems, devices, and techniques for training neural networks to identify avascular and signal reduction areas of Optical Coherence Tomography Angiography (OCTA) images and for using trained neural networks. By identifying signal reduction areas in OCTA images, the avascular areas can be detected with high accuracy, even when the OCTA images include artifacts and other types of noise. Accordingly, various implementations described herein can accurately identify avascular areas from real-world clinical OCTA images. In various implementations, a method can include identifying images of retinas. The images may include thickness images, reflectance intensity maps, and OCTA images of the retinas. Avascular maps corresponding to the OCTA images can be identified. A neural network can be trained based on the images and the avascular maps.

Abstract: Laser-Speckle Contrast imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 ?s), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus.

Abstract: One example method for improving the efficiency of robotic surgical procedures via surgical procedure data analysis. The method includes accessing surgical procedure data of a robotic surgical procedure. The surgical procedure data contains data or events associated with the robotic surgical system during the robotic surgical procedure. The method further includes accessing a procedure setup plan for the robotic surgical procedure corresponding to the surgical procedure data and determining an idle period of the surgical procedure based on the surgical procedure data. The method also includes analyzing the surgical procedure data to detect one or more events associated with the idle period to determine a cause of the idle period, and generating a recommendation for modifying the procedure setup plan for the robotic surgical procedure based on the determined cause of the idle period.

Abstract: This invention relates to a method and network system for selecting an appropriate bariatric surgery for a patient based upon baseline patient parameters.

Abstract: A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate. This cannulated needle is robotically controlled to provide motion into and out of the subject's skull. A flexible needle is disposed coaxially within the cannulated needle, and it is controlled to move into and out of a non-axial aperture in the distal part of the cannulated needle. Coordinated control of the insertion motion of the cannulated and flexible needles, and rotation of the combined cannulated/flexible needle assembly enables access to be obtained to a volume of a region of the brain having lateral dimensions substantially larger than the width of the cannulated needle.

Abstract: The present is directed to improved systems and methods for skin cooling treatments. A skin cooling treatment system can include a mechanical arm that can have a proximal end and an distal end. The system can include a processor that can control the mechanical arm, and a cryospray applicator. The cryospray applicator can be coupled to the distal end of the mechanical arm and can be moveable by the mechanical arm to deliver a spray of cryogen to a portion of an area of skin tissue for treatment. The cryospray applicator can include an array of orifices through which the cryogen can be sprayed.

Abstract: Methods, devices, and systems for acquiring the volume of a catheter are disclosed. The system may comprise a catheter and a processor. The processor may be configured to receive a voxel grid comprising a plurality of voxels and a plurality three-dimensional coordinates of a location of a catheter. The processor may render the catheter on a display using the three-dimensional coordinates, wherein the catheter rendering comprises a plurality of shaded pixels. The processor may identify coordinates of one or more voxels of the voxel grid which overlap with at least one shaded pixel and mark the voxels of the voxel grid which overlap with at least one shaded pixel. As such, a voxel trail may be created wherever a catheter moves. The voxel trail may be used to define an internal volume within which the catheter is positioned, such as a chamber of a heart, blood vessel, or valve.

Abstract: Methods, non-transitory computer readable media, surgical tracking devices, and systems that facilitate improved tracking in surgical environments are disclosed. With this technology, a fiber optic shape sensing (FOSS) device is rigidly attached to patient anatomy and/or surgical instrument(s) to facilitate location and/or flexibility tracking. The data provided by the FOSS device can be analyzed and registered to preoperative or intraoperative 3D anatomy model(s). The FOSS device can be attached to a surgical instrument to provide intraoperative guidance, used to locate a hollow needle for tracking bones in a minimally invasive manner, and/or used to detect bending in an instrument such as an arthroscope or tissue removing burr shaft, for example. The tracked location and/or flexibility data provided by the FOSS device can also be used to automatically control the location and/or operation of a surgical instrument during a surgical proceeding to facilitate improved surgical accuracy and patient outcomes.

Abstract: A method comprising segmenting at least one vertebral body from at least one image of a first three-dimensional image data set. The method comprises receiving at least one image of a second three-dimensional image data set. The method comprises registering the segmented at least one vertebral body from the at least one image of the first three-dimensional image data set with the at least one image of the second three-dimensional image data set. The method comprises determining a position of the at least one surgical implant based on the at least one image of the second three-dimensional image data set and a three-dimensional geometric model of the at least one surgical implant. The method comprises overlaying a virtual representation of the at least one surgical implant on the registered and segmented at least one vertebral body from the at least one image of the first three-dimensional image data set.

Abstract: Disclosed is an instrument assembly usable in a procedure. The instrument includes a connection for a working portion and to a tool handle. A tracking device or assembly may be associated with the instrument for determining a position of the instrument.

Abstract: A computer-assisted imaging and localization system assists the physician in positioning surgical effecters, such as implants, tools and instruments, within a surgical site in a patient's body. The system displays overlapping images—one image of the surgical site with the patient's anatomy and another image showing the surgical effecter(s). The overlapping image of the surgical effecter(s) is moved over the static image of the anatomy as the implant/instrument is moved. The movement of the surgical effecter(s) is determined in a three-dimensional coordinate system at a home base location in the patient's anatomy, which home base can be moved during the procedure without interrupting the displays of the overlapping images.

Abstract: Devices, systems, and methods for providing a surveillance marker configured to detecting movement of a dynamic reference base attached to a patient a robot-assisted surgical procedure are provided. The surveillance marker and the dynamic reference base are connected to a bony structure independent of each other.

Abstract: A robotic surgical tool comprises a stage assembly and a core assembly removably mountable to the stage assembly. The stage assembly may comprise a lead screw and at least one spline extendable between first and second ends of the stage assembly, and a nut rotatably mounted to the lead screw to translate between the first and second ends upon rotation of the lead screw. The core assembly may comprise a drive housing that is movably mountable to the stage assembly to translate, with the nut, between the first and second ends of the stage assembly. The surgical tool may also comprise a shroud assembly having a primary shroud and a secondary shroud, the primary shroud at least partially enclosing the core assembly when installed on the stage assembly, and the secondary shroud being movable between a first position, where the secondary shroud occludes an opening in the primary shroud, and a second position, where the opening in the primary shroud is exposed.

Abstract: The various inventions relate to robotic surgical devices, consoles for operating such surgical devices, operating theaters in which the various devices can be used, insertion systems for inserting and using the surgical devices, and related methods. A positionable camera is disposed therein, and the system is configured to execute a tracking and positioning algorithm to re-position and re-orient the camera tip.

Abstract: Disclosed is a surgical system, comprising an end effector configurable between an open state and a clamped state. The end effector comprises a first jaw and a second jaw moveable relative to the first jaw. The surgical system further comprises a drive system, comprising a motor and a drive assembly movable by the motor to effect a tissue-treatment motion at the end effector. The surgical system further comprises a motor control system comprising motor control electronics. The motor control system is configured to transmit a motor drive signal that causes the motor to move the drive assembly to effect the tissue-treatment motion at the end effector and control the motor control electronics to modify the tissue-treatment motion independent of the motor drive signal.

Abstract: A computer-assisted teleoperated surgical system includes one or more manipulator devices and other components. A manipulator device includes a first link, a second link coupled to a distal end of the first link, a third link coupled to the second link, and an instrument actuator coupled to the third link. A joint that couples the second link to the first link defines a yaw axis. A joint that couples the third link to the second link defines a pitch axis. The instrument actuator defines an insertion axis. The yaw, pitch, and insertion axes are fixed in relation to each other and intersect at a remote center of motion. The instrument actuator may insert a surgical instrument along the insertion axis roll and may roll the surgical instrument around the insertion axis. The proximal end of the first link may be coupled to a repositionable setup structure, which may optionally be mechanically grounded to an operating room table.

Abstract: A computer-assisted medical system includes robotic manipulators, a user input system operable to generate signals to control the manipulators, and a controller configured to execute instructions to perform operations. A portion of the user input system is movable relative to the plurality of manipulators. The operations include, in a pairing mode, associating a first manipulator of the plurality of manipulators with the portion of the user input system based on movement of the portion of the user input system relative to the first manipulator, and, in a following mode, controlling motion of the first manipulator in accordance with an indication generated by the user input system in response to operation of the portion of the user input system by a user.

Abstract: Techniques for operating a kinematic structure by manual motion of a link coupled to the kinematic structure include a system having a kinematic structure configured to support an instrument and a processor. The processor is configured to place the system in a clutching mode; transition the system from the clutching mode to a set-up mode in response to detecting a joint operation of the kinematic structure; while in the set-up mode, determine an input displacement of a link from an initial positional relationship relative to a portion of the kinematic structure to a displaced positional relationship relative to the portion of the kinematic structure; and while in the set-up mode and in response to the determined input displacement, drive the kinematic structure so that the link returns toward the initial positional relationship relative to the portion of the kinematic structure.

Abstract: Disclosed is a robotic surgical tool, comprising an end effector, an elongate shaft, and an articulation joint. The articulation joint comprises a pivot plate attached to the end effector, a fixed plate attached to the elongate shaft, and a spherical joint coupled to the pivot plate and the fixed plate. The robotic surgical tool further comprises an articulation drive system. The articulation drive system comprises a first rod, a second rod, a third rod, and a fourth rod that extend through the elongate shaft, a first mechanical link pivotably coupled to the first rod and to the pivot plate, a second mechanical link pivotably coupled to the second rod and to the pivot plate, a third mechanical link pivotably coupled to the third rod and to the pivot plate, and a fourth mechanical link pivotably coupled to the fourth rod and to the pivot plate.

Abstract: A catheter system for optical coherence tomography includes an elongate catheter body, an optical fiber in the elongate catheter body, and an anamorphic lens assembly coupled with a distal end of the optical fiber. The optical fiber and the lens assembly are together configured to provide a common path for optical radiation reflected from a target and from a reference interface between the distal end of the optical fiber and the lens assembly.

Abstract: An apparatus for estimating a core body temperature of an object is provided. The apparatus may include a heat flow sensor configured to measure a first heat flux from an object, a first temperature sensor positioned under a thermal conducting material and configured to measure a surface temperature of the object, a second temperature sensor positioned above the thermal conducting material and configured to measure a surface temperature of the thermal conducting material, and a processor configured to obtain a second heat flux by calibrating the first heat flux based on the surface temperature of the object and the surface temperature of the thermal conducting material, and configured to estimate a core body temperature of the object based on the obtained second heat flux and the surface temperature of the object.

Abstract: Described herein is a multi-dimensional kineticardiography device (300) which comprises a sensor (320) having three accelerometer/gyroscope modules (320X, 320Y, 320Z) mounted in a support which positions it at the centre of mass of a subject whose cardiac function is to be measured. The sensor (320) outputs six degrees of freedom data as linear acceleration along and rotational or angular velocity about x-, y- and z-axes. The sensor (320) is connected to a processor (335) for transmitting the kineticardiography data obtained from the sensor (320) and the electrocardiography data to a mobile computing platform (330), via Bluetooth (350), for further processing and display. An electrocardiography data chip (370) is also present for digitising the electrocardiography data for further processing.

Abstract: A wearable device for a noninvasive measurement of a user's body temperature can include a housing, a first substrate coupled to the housing and having an opening, a second substrate coupled to the first substrate and configured to secure to skin of a user, a mounting frame enclosed by the housing and the first substrate, a circuit board secured by the mounting frame, a temperature sensor coupled to the circuit board and configured to determine a body temperature of the user, and a thermally conductive probe. The thermally conductive probe is secured by the mounting frame and positioned proximate to the first temperature sensor. The thermally conductive probe extends at least partially through the opening in the first substrate and transmits a thermal energy from a portion of the user's skin to the first temperature sensor.

Abstract: An apparatus for estimating bio-information may include: a processor configured to measure a current time interval between a plurality of element waveforms of the pulse wave signal, determine whether a current measurement posture of the user corresponds to a reference posture based on the current time interval of the plurality of element waveforms, and estimate the bio-information based on a determination of whether the current measurement posture corresponds to the reference posture.

Abstract: An aspect of the present disclosure describes an apparatus for non-invasive blood pressure monitoring that includes a plurality of pressure sensors, a plurality of sensor interfaces coupling the plurality of pressure sensors to at least one blood flow line disposed exterior from a patient, a pump for artificially generating blood flow through the at least one blood flow line, and a processor configured to receive pressure sensor measurements from the plurality of pressure sensors and generate a patient blood pressure estimation from the combined pressure sensor measurements.

Abstract: Disclosed herein is a base device with a pump device for applying pressure to a working fluid and a body contact device that can be detachably coupled to one another. A housing of the base device has a contact surface for the body contact device where the contact surface has a passage which can be closed by means of a closing member of a valve device. A spring is provided for applying spring force to move the closing member into a position that closes the passage. The body contact device has a pressure applicator, which can be acted upon by the working fluid, to apply pressure to the finger and a sealing element for creating a fluid connection with the base device. The body contact device has a deflecting means for deflecting the closing member against the spring force in the operating configuration.

Abstract: A blood pressure measurement device includes an outer case; a base; a pump provided on the base such that the pump is shifted from a center of the outer case and located on one side as viewed in a circumferential direction of a living body; a drive unit provided on the base and located on one side of the pump as viewed in a direction orthogonal to the circumferential direction; an on-off valve provided on another side of the pump as viewed in the direction orthogonal to the circumferential direction; a pressure sensor provided on said another side of the pump as viewed in the direction orthogonal to the circumferential direction; and packing provided between the on-off valve and the pressure sensor and the base.

Abstract: An electronic device may include a PPG sensor including a light emitter that applies a current in a specified range and emits a light signal corresponding to the current and a light detector that amplifies a received light signal by applying one of a plurality of gain values, a memory that stores a plurality of sets of PPG models corresponding to the plurality of gain values and including a current value and PPG level data corresponding to the current value, and at least one processor electrically connected to the PPG sensor and the memory.

Abstract: A circulatory dynamic measuring apparatus includes: an electrocardiogram acquiring section which is configured to acquire an electrocardiogram of a subject; a pulse wave acquiring section which is configured to acquire a poise wave of an upper arm of the subject; and a calculator which is configured to calculate information that relates to a cardiac function of the subject, and that is based on a pulse wave transmit time obtained from the electrocardiogram and the pulse wave.

Abstract: Respiratory rate can be calculated from an acoustic input signal using time domain and frequency domain techniques. Confidence in the calculated respiratory rate can also be calculated using time domain and frequency domain techniques. Overall respiratory rate and confidence values can be obtained from the time and frequency domain calculations. The overall respiratory rate and confidence values can be output for presentation to a clinician.

Abstract: An implantable micro-biosensor a substrate, a first electrode, a second electrode, a third electrode, and a chemical reagent layer. The first electrode is disposed on the substrate and used as a counter electrode. The second electrode is disposed on the substrate and spaced apart from the first electrode. The third electrode is disposed on the substrate and used as a working electrode. The chemical reagent layer at least covers a sensing section of the third electrode so as to permit the third electrode to selectively cooperate with the first electrode or the first and second electrodes to measure a physiological signal in response to the physiological parameter of the analyte.

Abstract: A near-infrared spectroscopy system comprises a substrate, a light source emitting a set of wavelengths, an optical detector detecting the set of wavelengths, a processor in electronic communication with the light source bank and/or the optical detector, and a memory device in electronic communication with the processor. The light source bank, optical detector, processor, and memory device are mounted on the substrate, and a battery is in electronic communication with at least one of these components. Program instructions direct the processor to calculate an oxygenation level, compare that oxygenation level to a predetermined threshold, and optionally, activate a feedback device. A method of detecting an oxygenation level comprises mounting the system in a wearable article, calculating a baseline oxygenation level, regularly executing the program instructions to calculate the oxygenation level, and activating the feedback device.

Abstract: Electrochemical impedance spectroscopy (EIS) may be used in conjunction with continuous glucose monitoring (CGM) to enable identification of valid and reliable sensor data, as well implementation of Smart Calibration algorithms.

Abstract: Systems and methods are disclosed which provide for a “factory-calibrated” sensor. In doing so, the systems and methods include predictive prospective modeling of sensor behavior, and also include predictive modeling of physiology. With these two correction factors, a consistent determination of sensitivity can be achieved, thus achieving factory calibration.

Abstract: A biological fluid sampling transfer device adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid sampling transfer device is able to separate a plasma portion from a cellular portion. After separation, the biological fluid sampling transfer device is able to transfer the plasma portion of the blood sample to a point-of-care testing device. The biological fluid sampling transfer device also provides a closed sampling and transfer system that reduces the exposure of a blood sample and provides fast mixing of a blood sample with a sample stabilizer. The biological fluid sampling transfer device is engageable with a blood testing device for closed transfer of a portion of the plasma portion from the biological fluid sampling transfer device to the blood testing device. The blood testing device is adapted to receive the plasma portion to analyze the blood sample and obtain test results.

Abstract: An example information processing system executes a game application. The information processing system obtains user information for calculating information relating to sleep of a user, and calculates health information relating to sleep and/or fatigue of the user based on the obtained user information. The information processing system controls a game progress of the game application based on the health information.

Abstract: A sensor circuit that is capable of sensing of neural action potentials is disclosed. The circuit can be designed to minimize power dissipation and total silicon area so that it can be incorporated into a massively parallel sensor array and ultimately implanted in the body (e.g. into the brain) in a safe manner. The circuit can also be designed to be tunable such that it can be optimized in silico prior to fabrication, and can be optimized through the use of controllable current sources after fabrication.

Abstract: An intrauterine balloon apparatus to augment uterine birthing forces and assist fetal descent during parturition is provided. The body of the balloon apparatus begins packaged in a compressed state minimizing volume, enabling delivery through the birth canal. The apparatus is advanced to a proximal uterine location and deployed for operation by introducing a pressurized agent through its conduit, causing the body to expand and apply directional forces towards the infant and birth canal. The balloon body is shaped to apply pressures dispersed towards the infant and the bidirectional conduit enables fluid conduction as the infant descends. After the infant has successfully descended and been delivered through the birth canal, pressure within the balloon body is relieved through the conduit thereby collapsing the volume of the balloon body and enabling retraction through the birth canal.