Patents Issued in May 14, 2024
  • Patent number: 11981943
    Abstract: The present disclosure provides CAPN5 substrates and CAPN5 inhibitors, nucleic acids encoding CAPN5 substrates or CAPN5 inhibitors, methods to deliver CAPN5 substrate or CAPN5 inhibitor agents to the eye, and methods of identifying inhibitors of CAPN5.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: May 14, 2024
    Assignee: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: Vinit B. Mahajan, Alexander G. Bassuk, Diana F. Colgan, Gabriel Velez, Kellie Schaefer, Marcus Toral, Shu Wu, Lokesh Gakhar
  • Patent number: 11981944
    Abstract: The present invention relates to immunogenic polypeptide fragments of a human Arginase protein. The fragments are in particular useful for the treatment or prevention of cancer.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: May 14, 2024
    Assignee: IO Biotech ApS
    Inventor: Mads Hald Andersen
  • Patent number: 11981945
    Abstract: The present invention relates to a process of producing a monoterpene and/or derivatives thereof. The process comprises the steps of: a) providing a host microorganism genetically engineered to express a bacterial monoterpene synthase (mTS); and b) contacting geranyl pyrophosphate (GPP) with said bacterial mTS to produce said monoterpene and/or derivatives thereof. The present invention also relates to a microorganism for use in producing a monoterpene and/or derivatives thereof and a recombinant microor-ganism adapted to conduct the step of converting geranyl pyrophosphate (GPP) into a monoterpene and/or derivatives thereof by ex-pression of a bacterial mTS. It was shown to produce 1,8 cineole using 1,8 cineole synthase and to produce linalool using linalool synthase, both from Streptomyces clavuligerus.
    Type: Grant
    Filed: April 23, 2021
    Date of Patent: May 14, 2024
    Assignee: C3 BIOTECHNOLOGIES LIMITED
    Inventors: Vijaykumar Karuppiah, Nicole G. H. Leferink, Nigel S. Scrutton
  • Patent number: 11981946
    Abstract: Recombinant microorganisms configured for enhanced production of compounds such as 2-pyrone-4,6-dicarboxylic acid (PDC) and methods of using the recombinant microorganisms for the production of these compounds. The recombinant microorganisms include one or more modifications that reduce 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) cis-trans isomerase activity, 4-carboxy-2-hydroxy-6-methoxy-6-oxohexa-2,4-dienoate (CHMOD) methyl esterase activity, and/or vanillate/3-O-methylgallate O-demethylase activity. The recombinant microorganisms can be used to generate PDC from media comprising plant-derived phenolics, such as syringyl phenolics, guaiacyl phenolics, and p-hydroxyphenyl phenolics. The plant-derived phenolics can be derived from pretreated lignin, including depolymerized lignin or other chemically altered lignin.
    Type: Grant
    Filed: May 6, 2021
    Date of Patent: May 14, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Daniel R. Noguera, Timothy James Donohue, Jose Perez, Wayne S. Kontur, German Eduardo Umana Chapeton
  • Patent number: 11981947
    Abstract: The present invention relates to the use of one or more glycosidases in the process for the production and/or purification of a produced desired oligosaccharide. The process is preferably a microbial fermentation process using a host microorganism, which may also comprise nucleic acids expressing sugar catabolic pathway proteins suitable for the degradation of saccharides otherwise hindering the purification of the desired oligosaccharide.
    Type: Grant
    Filed: July 22, 2022
    Date of Patent: May 14, 2024
    Assignee: Chr. Hansen HMO GmbH
    Inventor: Stefan Jennewein
  • Patent number: 11981948
    Abstract: Described herein are engineered organelles comprising multi-component proteins from different species incorporated into a membrane structure with interior and exterior aspects. In one embodiment the artificial organelle incorporates one or more protein complexes that absorb optical energy and catalyze electron transfer in biochemical reactions that can be used to reduce NAD+ to NADH or analogues thereof.
    Type: Grant
    Filed: November 2, 2022
    Date of Patent: May 14, 2024
    Assignee: Ensovi, Inc.
    Inventors: Kyle A Minor, Carlo D. Montemagno, David W. Wendell
  • Patent number: 11981949
    Abstract: A system and method for producing biogas (methane) from a mixture of poultry manure and methanogens through an anerobic digestion process which makes use of jute filters within the chamber to absorb excess ammonium nitrogen from the mixture of poultry manure.
    Type: Grant
    Filed: November 14, 2023
    Date of Patent: May 14, 2024
    Assignee: KING FAISAL UNIVERSITY
    Inventors: Muhammad Aamir, Muhammad Hassan, Shah Fahad Bin Masud
  • Patent number: 11981950
    Abstract: A process includes providing a gaseous substrate comprising CO2 to a bioreactor; providing acetogenic bacteria and medium to the bioreactor to provide a fermentation broth; providing sodium ions to the bioreactor through one or more sodium ion sources; fermenting the gaseous substrate with the acetogenic bacteria in the fermentation broth to produce one or more organic acids; and controlling a butyric acid to an acetic acid ratio by controlling the pH of the fermentation broth. In one aspect, butyric acid to acetic acid ratio increases when the pH of the fermentation broth decreases, and the ratio of butyric acid to acetic acid concentration decreases when the pH of the fermentation broth increases. The acetogenic bacteria includes a sodium translocating ATPase that is active during fermentation in the bioreactor. The sodium ions are provided so that Na+ is maintained between 1000 to 11000 ppm (g/g) in culture broth.
    Type: Grant
    Filed: January 27, 2021
    Date of Patent: May 14, 2024
    Inventors: Ryan Senaratne, Brandon Beard
  • Patent number: 11981951
    Abstract: The present invention relates to a process for the production of methyl methacrylate. The process of the present invention comprises the steps of: a) providing a microorganism in a fermentation medium, under conditions which said microorganism will produce a C3-C12 methacrylate ester; b) providing an organic phase in contact with the fermentation medium, said organic phase including C3-C12 methacrylate ester in a higher concentration than that in the fermentation medium; c) removing organic phase containing the said C3-C12 methacrylate ester from contact with the fermentation medium; and d) transesterifying the removed C3-C12 methacrylate ester with methanol, optionally after separation from the organic phase, to produce methyl methacrylate.
    Type: Grant
    Filed: November 22, 2017
    Date of Patent: May 14, 2024
    Assignee: Mitsubishi Chemical UK Limited
    Inventors: Graham Ronald Eastham, Zoe Bethany Clare Disley, David William Johnson, Gill Stephens, Mark Waugh
  • Patent number: 11981952
    Abstract: The disclosure relates to omega-hydroxylated fatty acid derivatives and methods of producing them. Herein, the disclosure encompasses a novel and environmentally friendly production method that provides omega-hydroxylated fatty acid derivatives at high purity and yield. Further encompassed are recombinant microorganisms that produce omega-hydroxylated fatty acid derivatives through selective fermentation.
    Type: Grant
    Filed: June 29, 2020
    Date of Patent: May 14, 2024
    Assignee: Genomatica, Inc.
    Inventors: Andreas W. Schirmer, Haibo Wang, Stephen B. Del Cardayre, Zhihao Hu, Louis G. Hom, Baolong Zhu, Cindy Chang, Emanuela E. Popova
  • Patent number: 11981953
    Abstract: A method of testing compounds for activity to inhibit germination of spores. The method includes the steps of providing bacterial, fungal, or plant spores transformed to contain and express a detectable marker, wherein the marker when expressed, is operationally linked to a spore-specific or yeast-specific protein, in a medium and under environmental conditions in which the spores will germinate, and measuring a first signal output generated by the marker prior to the spores initiating germination; contacting the spores of step (a) with a compound whose activity to inhibit germination of spores is to be measured; incubating the spores of step (b) under environmental conditions and for a time wherein spores not treated with the compound will germinate; and determining extent of germination of the spores by measuring a second signal output generated by the marker, wherein a difference between the first signal output and the second signal output is proportional to the extent of germination of the spores.
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: May 14, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Christina Marie Hull, Mingwei Huang, Sebastien Claude Ortiz
  • Patent number: 11981954
    Abstract: The present invention relates to compositions and methods for the use of polymerase chain reaction (PCR) as a reporter assay for rapid and simultaneous bacterial identification and phenotype testing for antimicrobial susceptibility (AST). The current invention uses a strategy that has shown the ability for multiplexing and for handling polymicrobial samples for antimicrobial susceptibility testing.
    Type: Grant
    Filed: July 13, 2022
    Date of Patent: May 14, 2024
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Kyle C. Cady, Brett Hanson, Paulino Abdon, Ryan Chan, Patrick Lin, Rochak Mehta, Troy Rabang
  • Patent number: 11981955
    Abstract: The present disclosure relates to new compounds and their use as fluorescent labels. The compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: December 6, 2022
    Date of Patent: May 14, 2024
    Assignee: Illumina Cambridge Limited
    Inventors: Antoine Francais, Xiaohai Liu
  • Patent number: 11981956
    Abstract: Provided herein, in some embodiments, are compositions and methods for proximity detection of molecular targets.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: May 14, 2024
    Assignee: President and Fellows of Harvard College
    Inventors: Sinem K. Saka, Jocelyn Yoshiko Kishi, Peng Yin
  • Patent number: 11981957
    Abstract: Biomarkers relevant to neurons in the brain, in particular at single cell levels, are identified by using olfactory neurons as the best surrogates from subjects so as to establish diagnosis, prognosis, and treatment of brain conditions.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: May 14, 2024
    Assignee: The Johns Hopkins University
    Inventors: Akira Sawa, Koko Ishizuka, YeeWen Candace Wu, Youjin Chung, Nao J. Gamo
  • Patent number: 11981958
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using DNA templated ligation. For example, provided herein are methods for detecting an gDNA analyte in a biological sample where (i) the first RTL probe and second RTL probe hybridize to adjacent sequences on the gDNA analyte, (ii) enzyme-mediate cleavage of a 5? FLAP results in release of the 5? FLAP, and (iii) the sequence of the 5? FLAP is determined and used to detect the gDNA analyte in the biological sample.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: May 14, 2024
    Assignee: 10x Genomics, Inc.
    Inventor: Christina Galonska
  • Patent number: 11981959
    Abstract: Heritable pathogenic variants in the mismatch repair (MMR) pathway, also known as Lynch Syndrome (LS), can lead to the development of colon cancer and other cancers. Following mismatch, a complex of proteins consisting of MLH1, MSH2, MSH6 and PMS2 translocate into the nucleus to signal recruitment of repair mechanisms. Flow cytometry-based, functional variant assays (FVAs), were developed to determine whether variants in these MMR repair genes and/or other related genes would augment the nuclear translocation of MLH1 and MSH2 and downstream nuclear phosphorylation of ATM and ATR in response to DNA mismatches. Each assay distinguished pathogenic variants in MMR repair genes (MLH1, MSH2, PMS2 and MSH6) from benign controls. The combination of multiple assays provided robust separation between heterozygous pathogenic variant carriers and benign controls.
    Type: Grant
    Filed: May 19, 2022
    Date of Patent: May 14, 2024
    Inventors: Harry Ostrer, Johnny C. Loke, Ishraq Alim
  • Patent number: 11981960
    Abstract: Provided are methods of capturing an analyte from a biological sample using a hydrogel that includes capture probes to capture the analyte, identifying a region of interest of the biological sample, and isolating the region of interest from the biological sample by removing a portion of the hydrogel that corresponds to the region of interest. Compositions and kits for performing the methods are also provided.
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: May 14, 2024
    Assignee: 10x Genomics, Inc.
    Inventors: Bill Kengli Lin, Jill Herschleb, Cedric Uytingco
  • Patent number: 11981961
    Abstract: Methods for constructing consecutively connected copies of nucleic acid molecules are disclosed. Consecutively connected copies of nucleic acid molecules can be used to perform sequencing of the same nucleic acid molecules several times, improving overall accuracy of sequencing. Connected copies of nucleic acid molecules can be constructed by circularizing nucleic acid molecules, performing rolling circle amplification and debranching with nicking and polymerases comprising 5?-3? exonuclease and/or flap endonuclease activity.
    Type: Grant
    Filed: January 21, 2018
    Date of Patent: May 14, 2024
    Assignee: Vastogen, Inc.
    Inventor: Dimitra Tsavachidou
  • Patent number: 11981962
    Abstract: This document provides methods and materials for using low coverage whole genome sequencing techniques to assess genomes. For example, methods and materials for using targeted nucleic acid amplification and/or capture techniques in combination with low coverage whole genome sequencing techniques to obtain high coverage sequencing data for one or more pre-selected regions of a genome are provided.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: May 14, 2024
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Jean-Pierre A. Kocher, Chen Wang
  • Patent number: 11981963
    Abstract: Methods for analyzing a nucleic acid molecule are described. Methods may include attaching the nucleic acid molecule to a particle having a first characteristic dimension. In addition, methods may include applying an electric field through an aperture to move the particle to the aperture. Also, methods may include applying a voltage across a first electrode and a second electrode. Further, methods may include contacting a portion of the nucleic acid molecule to both the first electrode and the second electrode within the aperture, where the portion may include a nucleotide. In addition, methods may include measuring a current through the first electrode, the portion of the nucleic acid molecule, and the second electrode, where the measured current runs in a direction parallel to a longitudinal axis of the aperture. Also, methods may include identifying the nucleotide of the portion of the nucleic acid molecule based on the current.
    Type: Grant
    Filed: March 21, 2023
    Date of Patent: May 14, 2024
    Assignee: Roche Sequencing Solutions, Inc.
    Inventor: Yann Astier
  • Patent number: 11981964
    Abstract: The present application relates to substituted coumarin derivatives and their uses as fluorescent labels. These compounds may be used as fluorescent labels for nucleotides in nucleic acid sequencing applications.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: May 14, 2024
    Assignee: Illumina Cambridge Limited
    Inventors: Nikolai Nikolaevich Romanov, Michael Callingham, Carole Anastasi, Patrick Mccauley, Niall Hynes, Natasha Crake, Xiaolin Wu, Xiaohai Liu
  • Patent number: 11981965
    Abstract: Provided herein are methods of detecting an analyte of interest to interrogate spatial gene expression in a sample using RNA-templated ligation.
    Type: Grant
    Filed: January 23, 2023
    Date of Patent: May 14, 2024
    Assignee: 10x Genomics, Inc.
    Inventors: James Michael Chell, Marlon Stoeckius, Jonathan Alles, Caroline Julie Gallant, Christina Galonska, Felice Alessio Bava, Layla Katiraee
  • Patent number: 11981966
    Abstract: The present technology relates to methods for determining whether a patient diagnosed with breast cancer, colorectal cancer, melanoma or lung cancer will benefit from or is predicted to be responsive to treatment with an individual therapeutic agent or a specific combination of therapeutic agents. These methods are based on screening a patient's solid tumors and detecting alterations in target nucleic acid sequences corresponding to a specific set of cancer-related genes. Kits for use in practicing the methods are also provided.
    Type: Grant
    Filed: May 8, 2020
    Date of Patent: May 14, 2024
    Assignee: Quest Diagnostics Investments LLC
    Inventors: Heather Sanders, Kevin Qu, James Prentice, Frederic Waldman
  • Patent number: 11981967
    Abstract: The present disclosure provides methods and compositions to develop AAV capsids with a desired characteristic compared to a natural AAV serotype. These capsids are useful, for example, for the delivery of genome engineering molecules and gene therapy molecules for the treatment of a subject in need thereof.
    Type: Grant
    Filed: April 24, 2020
    Date of Patent: May 14, 2024
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Kyle McGovern, David S. Ojala
  • Patent number: 11981968
    Abstract: The invention relates to a continuous method for obtaining a crystalline monosaccharide, comprising: continuous crystallization of the monosaccharide in a main crystallizer (10), wherein crystallization by evaporation and/or crystallization by cooling is carried out continuously on a crystal suspension in the main crystallizer in order to allow crystals of the monosaccharide to grow in the crystal suspension; separation of crystals of the monosaccharide out of the crystal suspension to obtain crystalline monosaccharide; continuous formation of a mass of crystallization magma for the main crystallizer (10) in a cascade, wherein the cascade comprises at least one first stage (13) and a final stage (15) connected in series and each stage comprises at least one pre-crystallizer (13A, 15A), wherein, in the at least one pre-crystallizer (13A) of the first stage (13), a solution is seeded with monosaccharide by means of monosaccharide seed crystals in order to obtain a pre-crystallization magma, and a mass of crysta
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: May 14, 2024
    Assignee: BMA BRAUNSCHWEIGISCHE MASCHINENBAUANSTALT AG
    Inventors: Mirko Löhn, Holger Fersterra
  • Patent number: 11981969
    Abstract: A leather finishing agent that can enhance the mechanical properties and ultraviolet resistance of leather and a preparation method thereof are disclosed that relate to the field of leather additives. It was prepared by using polyphenol as raw material, hexamethylene tetramine as auxiliary agent, and a protonic acid as solvent, then heating and adding water for hydrolysis and dispersion. The method has the advantages of low production cost, simple process, high preparation efficiency, green production process and environmental protection. The leather finishing agent can be used in the finishing section after leather tanning. After finishing, the mechanical properties of the leather were significantly enhanced, and its UV resistance was also significantly improved.
    Type: Grant
    Filed: May 12, 2021
    Date of Patent: May 14, 2024
    Assignee: Shaanxi University of Science & Technology
    Inventors: Taotao Qiang, Linxin Guo, Yangmin Ma, Tingting Dai
  • Patent number: 11981970
    Abstract: Disclosed are a leather odor removal composition, a method of manufacturing leather with reduced odor using the same, and leather manufactured through the method. The method of reducing leather odor may include using a composition including a filler and a softening mixture.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: May 14, 2024
    Assignees: Hyundai Motor Company, Kia Corporation
    Inventors: Sung Hoon Lee, Ha Young Yoon, Myoung Ryoul Lee, Seung Jin Lee, Eun Ju Noh
  • Patent number: 11981971
    Abstract: The invention relates to a method for cooling a tool in a heat treatment furnace, wherein: the tool is supplied during normal cooling operation with coolant from a coolant reservoir through a supply inlet (1), which coolant is returned into the coolant reservoir from the tool via a return flow (2); the supply inlet (1) is coupled by means of an electric actuator (3) alternatively to the coolant reservoir or to the public water supply and the return flow (2) is coupled by means of a further electric actuator (3) alternatively to the coolant reservoir or to the public waste water system (4); the actuators (3, 3?) are supplied with a feed current during normal cooling operation and held in a first position in which coolant is supplied to the tool through the supply inlet (5) from the coolant reservoir and the coolant is fed back through the return flow (2, 6) into the coolant reservoir; and, upon interruption in the power supply, the actuators (3, 3?) are forced into an emergency position in which cold water is
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: May 14, 2024
    Assignee: GEDIA GEBRUEDER DINGERKUS GMBH
    Inventors: Volker Flesch, Bjoern Mueller, Patrick Mueller, Maik Winderlich, Thorsten Wisnia
  • Patent number: 11981972
    Abstract: There is disclosed a softening method for a high-strength Q & P steel hot-rolled coil, comprising: after heating a Q & P steel ingot, subjecting it to rough rolling, finish rolling, laminar cooling and coiling to obtain a hot-rolled coil; after unloading the coil, covering the coil on-line with an insulating enclosure and moving it into a steel coil warehouse along with a transport chain; after a specified period of insulating time, removing the coil from the insulating enclosure, and cooling it to room temperature in air, wherein the coiling is performed at a temperature of 400-600° C.; said covering on-line with an insulating enclosure means each hot-rolled coil is individually covered with an independent, closed insulating enclosure unit within 60 minutes after unloading; the insulating time of the steel coil in the insulating enclosure is ?60 minutes. The inventive method replaces the intermediate annealing step in the production process of cold-rolled Q & P steel.
    Type: Grant
    Filed: September 20, 2018
    Date of Patent: May 14, 2024
    Assignees: BAOSTEEL ZHANJIAN IRON & STEEL CO., LTD., BAOSHAN IRON & STEEL CO., LTD.
    Inventors: Xingjian Gao, Jiachun Xu, Ye Wang
  • Patent number: 11981973
    Abstract: The present disclosure relates to a zinc plated steel sheet having excellent fatigue strength of electrical resistance spot welds and a method for manufacturing the same. According to an aspect of the present disclosure, a zinc plated steel sheet includes a base steel sheet and a zinc-based plating layer formed on a surface of the base steel sheet, wherein a concentration profile of one or two of oxygen, and silicon and manganese measured in a depth direction from the surface of the base steel sheet has a maximum point in the depth direction from the surface, and an absolute value of a difference between a depth at which the maximum point of the concentration profile of oxygen is formed and a depth at which the maximum point of the concentration profile of one of silicon and manganese is formed is 0.5 ?m or less.
    Type: Grant
    Filed: December 3, 2020
    Date of Patent: May 14, 2024
    Assignee: POSCO
    Inventors: Ki-Cheol Kang, Chung-Hwan Lee
  • Patent number: 11981974
    Abstract: A method for the manufacturing of an object. The method includes receiving a desired alloy composition for the object, depositing a plurality of foils in a stack to form the object, applying heat to the stack at a first temperature to bond the plurality of foils to each other, and applying heat to the stack at a second temperature to homogenize the composition of the stack. The homogenized stack has the desired alloy composition.
    Type: Grant
    Filed: April 5, 2023
    Date of Patent: May 14, 2024
    Assignee: Alloy Enterprises Inc.
    Inventors: Nicholas Mykulowycz, Alison Forsyth, Alan Lai, Lyle Cheatham
  • Patent number: 11981975
    Abstract: Provided is a method for manufacturing a steel sheet, the method including: reheating a steel slab at a temperature of 1200° C. to 1350° C., the steel slab including, by weight %, carbon (C): 0.05% to 0.14%, silicon (Si): 0.01% to 1.0%, manganese (Mn): 1.5% to 2.5%, aluminum (Al): 0.01% to 0.1%, chromium (Cr): 0.005% to 1.0%, phosphorus (P): 0.001% to 0.05%, sulfur (S): 0.001% to 0.01%, nitrogen (N): 0.001% to 0.01%, niobium (Nb): 0.005% to 0.06%, titanium (Ti): 0.005% to 0.11%, and a balance of iron (Fe) and inevitable impurities; finish hot rolling the reheated steel slab under predetermined conditions to obtain a hot-rolled steel sheet; cooling the hot-rolled steel sheet at a cooling rate of 10° C./s to 100° C./s to a temperature of 400° C. to 500° C. after the finish hot rolling; and coiling the steel sheet at a temperature of 400° C. to 500° C. after the cooling.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: May 14, 2024
    Assignee: POSCO CO., LTD
    Inventors: Sung-Il Kim, Hyun-Taek Na, Dong-Wan Kim
  • Patent number: 11981976
    Abstract: Disclosed is a method for purifying a nickel-cobalt-manganese leaching solution.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: May 14, 2024
    Assignees: GUANGDONG BRUNP RECYCLING TECHNOLOGY CO., LTD., HUNAN BRUNP RECYCLING TECHNOLOGY CO., LTD., HUNAN BRUNP VEHICLES RECYCLING CO., LTD.
    Inventors: Ran He, Honghui Tang, Minjie Ye, Dongren Lyu, Bo Liu, Changdong Li
  • Patent number: 11981977
    Abstract: A method and a system, the system, comprising a laser source, a ionization and acceleration unit, a separation unit, and a collecting unit, wherein the laser source comprises a large bandwidth laser delivering successive pulses of fixed central wavelength and bandwidth to a surface of a target positioned inside the ionization and acceleration unit, surface atoms of the target being ionized by the pulses, accelerated from the surface of the target to a kinetic energy in the range between 100 eV and 10 KeV, and focused to the separation unit, the separation unit separating received atoms into different ions species, and the collecting unit separately collecting the different ion species.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: May 14, 2024
    Assignee: INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Stéphane Payeur, François Légaré, Jean-Claude Kieffer
  • Patent number: 11981978
    Abstract: A method for preparing high-purity nickel-based superalloy includes the steps of: performing electron beam smelting on small cylinders in a first water-cooled copper crucible after preheating an electron gun, and converging the beam to the edge of one side of the ingot; turning on the electron gun again after completely solidifying the ingot, the electron beam spot uniformly and slowly scanning a surface of the ingot from a side opposite to a final beam converging area of the ingot to the final beam converging area of the ingot to ensure that the alloy at a position scanned by the electron beam spot is completely melted, and stopping scanning once scanning to the final converging area of the ingot; casting the molten alloy in the first water-cooled copper crucible to the second water-cooled copper crucible; taking out the refined nickel-base superalloy after cooling down the electron beam melting furnace.
    Type: Grant
    Filed: June 12, 2020
    Date of Patent: May 14, 2024
    Assignee: DALIAN UNIVERSITY OF TECHNOLOGY
    Inventors: Yi Tan, Xinpeng Zhuang, Longhai Zhao, Xiaogang You, Pengting Li, Yinong Wang
  • Patent number: 11981979
    Abstract: A device and method for preparing a low-impurity regenerated brass alloy through step-by-step insertion of an electrode are provided. The device includes a melt heating apparatus, an electrode displacement apparatus, and a pulse current generation apparatus. The automatic electrode lifting apparatus is controlled to adjust an insertion depth of the graphite electrode plate in the metal melt, and the pulse current generation apparatus is controlled to adjust the parameters of pulse current to achieve the impurity reduction on the metal melt. The preparation of a low-impurity regenerated brass alloy involves a short production process, simple operations, low energy consumption, and high impurity removal efficiency, and is suitable for regeneration and large-scale continuous production of non-ferrous metal alloys.
    Type: Grant
    Filed: October 12, 2023
    Date of Patent: May 14, 2024
    Assignee: UNIVERSITY OF SCIENCE AND TECHNOLOGY BEIJING
    Inventors: Xinfang Zhang, Baoyu Zhang, Xiaoshan Huang, Mengcheng Zhou, Changhao Liu, Di Zhang, Longge Yan
  • Patent number: 11981980
    Abstract: Disclosed is a sulfur-doped micro zero-valent metal reducing agent containing a zero-valent metal, wherein a metal sulfide layer synthesized using a ball milling process may be formed on a surface of the zero-valent metal. In addition, disclosed is a method for preparing a sulfur-doped micro zero-valent metal reducing agent including, in a ball milling process using a ball milling apparatus composed of a jar, balls, and a body, a first step of preparing an inorganic mixture by mixing a zero-valent metal and sulfur with each other, and a second step of forming a metal sulfide layer synthesized on a surface of the zero-valent metal by putting the inorganic mixture into the jar together with the balls and performing ball milling.
    Type: Grant
    Filed: October 13, 2020
    Date of Patent: May 14, 2024
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Jeehyeong Khim, Mingcan Cui, Jongbok Choi, Yonghyun Lee
  • Patent number: 11981981
    Abstract: Preform and manufacturing process producing heterogeneous components with a first fraction (11) made from a first metallic material and having a cellular structure with stochastic or regular cells, and a second fraction (12) made from a second metallic material different from the first metallic material, in which the second fraction (12) at least partly infiltrates the cells of the first fraction (11). The second fraction is poured into the preform which also acts as a mould. The finished product after machining may have a unified surface of the second fraction or several zones exposing the second fraction, the first fraction, the cellular structure which is open or infiltrated with the second metallic fraction, or open zones, in a predetermined design.
    Type: Grant
    Filed: August 14, 2020
    Date of Patent: May 14, 2024
    Assignee: Manufacture D'Horlogerie Audemars Piguet SA
    Inventors: Thibaut Le Loarer, Sandra Guadalupe Maldonado
  • Patent number: 11981983
    Abstract: The invention discloses a composite rare earth anisotropic bonded magnet and a preparation method thereof. The composite rare earth anisotropic bonded magnet comprises a Nd—Fe—B magnetic powder, a Sm—Fe—N magnetic powder, a binder and an inorganic nano-dispersant. The preparation method comprises steps of preparing a Nd—Fe—B magnetic powder by a HDDR method, preparing a Sm—Fe—N magnetic powder by a powder metallurgy method, mixing the Nd—Fe—B magnetic powder, the Sm—Fe—N magnetic powder, the binder and the inorganic nano-dispersant at a specific ratio to finally obtain the composite rare earth anisotropic bonded magnet. The invention, by adding an inorganic nano-dispersant, enables the full dispersion of the fine Sm—Fe—N powder during the mixing process of the binder, the Nd—Fe—B magnetic powder and the Sm—Fe—N powder, and thus makes the fine Sm—Fe—N powder and the binder evenly coated on the surface of the anisotropic Nd—Fe—B magnetic powder.
    Type: Grant
    Filed: November 5, 2020
    Date of Patent: May 14, 2024
    Assignees: GRIREM ADVANCED MATERIALS CO., LTD., GRIREM HI-TECH CO., LTD.
    Inventors: Yang Luo, Zhongkai Wang, Yuanfei Yang, Zilong Wang, Dunbo Yu, Yifan Liao, Jiajun Xie, Zhou Hu
  • Patent number: 11981984
    Abstract: Provided is a hot rolled steel sheet having a tensile strength of 780 MPa or more, a sheet thickness of 1.2 to 4.0 mm, and a sheet width of 750 mm or more, and satisfying ?15?(?W 1+?W 2)/2??C?15 (where ?W 1 and ?W 2 respectively indicate hole expansion ratios (%) at ? positions of the sheet width from one end of the hot rolled steel sheet in a sheet width direction perpendicular to a rolling direction and the other end at an opposite side, and ?C indicates a hole expansion ratio (%) of a sheet width center part).
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: May 14, 2024
    Assignee: NIPPON STEEL CORPORATION
    Inventors: Takeshi Toyoda, Eisaku Sakurada
  • Patent number: 11981985
    Abstract: The disclosure discloses a method for manufacturing special purpose vehicle wheels by using 7000 series aluminum alloys, comprising the following steps: step 1, smelting 7000 series aluminum alloys in a smelting furnace; step 2, making the solution obtained in step 1 into an aluminum alloy ingot blank through a spraying and forming process; step 3, extruding the aluminum alloy ingot blank of step 2 to obtain an extrusion bar; step 4, sawing the extrusion bar into blanks and heating them; step 5, rolling the blank into a cake; step 6, putting the cake into a press for forging and forming; step 7, spinning and forming the wheel rim. The wheel manufactured by the method for manufacturing special vehicle wheels with 7000 series aluminum alloys in the present disclosure has high and stable conductivity, qualified impact test and good bending and radial fatigue performance.
    Type: Grant
    Filed: January 14, 2022
    Date of Patent: May 14, 2024
    Assignee: CITIC Dicastal Co., Ltd.
    Inventors: Tieqiang Chen, Zuo Xu, Zhihua Zhu, Qingzhu Zhang, Lixin Huang, Meng Li
  • Patent number: 11981986
    Abstract: The invention relates to a wrought 7xxx-series aluminium alloy product having a composition comprising, in wt. %, Zn 6.40 to 7.50, Mg 2.15 to 2.75, Cu 1.20 to 2.00, and wherein Cu+Mg<4.50, and wherein Mg<2.5+5/3(Cu?1.2), Fe up to 0.25, Si up to 0.25, and optionally one or more elements selected from the group consisting of: (Zr up to 0.3, Cr up to 0.3, Mn up to 0.45, Ti up to 0.25, Sc up to 0.5, Ag up to 0.5), the balance being aluminium and impurities, and having been aged to achieve a conventional tensile yield strength (in MPa) measured in the L-direction measured at quarter thickness of more than 485?0.
    Type: Grant
    Filed: January 9, 2020
    Date of Patent: May 14, 2024
    Assignee: NOVELIS KOBLENZ GMBH
    Inventors: Achim Bürger, Sunil Khosla, Christian Gerhard Krechel, Sabine Maria Spangel, Philippe Meyer
  • Patent number: 11981987
    Abstract: A deposition nozzle is provided that includes offset deposition apertures disposed between exhaust apertures on either side of the deposition apertures. The provided nozzle arrangements allow for deposition of material with a deposition profile suitable for use in devices such as OLEDs.
    Type: Grant
    Filed: October 26, 2021
    Date of Patent: May 14, 2024
    Assignee: Universal Display Corporation
    Inventors: Edwin van den Tillaart, Sven Pekelder, Mark Meuwese, William E. Quinn, Gregory McGraw, Gregg Kottas
  • Patent number: 11981989
    Abstract: Methods and apparatus for processing a substrate are provided herein. For example, a cooling apparatus for use with a substrate support of a processing chamber comprises a heat exchanger, a manifold assembly comprising a first input configured to connect to an output of the heat exchanger, a second input configured to connect to a first coolant supply configured to supply a first coolant, a first output configured to connect to the substrate support of the processing chamber, and a second output configured to connect to an input of the heat exchanger, a gas input configured to connect to a second coolant supply that is configured to supply a second coolant that is different from the first coolant to the substrate support, a first three-way valve connected between the first output of the manifold assembly and the substrate support and connected between the gas input and the substrate support, and a controller configured to control supplying one of the first coolant or the second coolant during operation.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: May 14, 2024
    Assignee: APPLIED MATERIALS, INC.
    Inventors: Robert Hartwig, Dinkesh Huderi Somanna, Brian T. West
  • Patent number: 11981990
    Abstract: The invention provides a deposition equipment with a shielding mechanism, which includes a reaction chamber, a carrier, a cover ring and a shielding mechanism. The shielding mechanism includes a first bearing arm, a second bearing arm, a first shielding plate and a second shielding plate. The first and second shielding plates are respectively placed on the first and second bearing arms. There are corresponding alignment units between the lower surface of the first and second shielding plates and the upper surface the carrier, so that the first and second shielding plates can be aligned with the carrier. There is also a corresponding alignment unit between the upper surface of the first and second shielding plates and the lower surface the cover ring, so that the cover ring can be aligned with the first and second shielding plates to define a cleaning space in the reaction chamber.
    Type: Grant
    Filed: August 30, 2022
    Date of Patent: May 14, 2024
    Assignee: SKY TECH INC.
    Inventors: Jing-Cheng Lin, Yu-Te Shen
  • Patent number: 11981991
    Abstract: An aluminum or copper alloy sputtering chamber includes a front surface, a back surface opposite the front surface, and a sputter trap formed on at least a portion of the front surface A coating of titanium particles is formed on the sputter trap.
    Type: Grant
    Filed: January 9, 2023
    Date of Patent: May 14, 2024
    Assignee: Honeywell International Inc.
    Inventors: Jaeyeon Kim, Patrick Underwood, Susan D. Strothers, Shih-Yao Lin, Michael D. Payton, Scott R. Sayles
  • Patent number: 11981992
    Abstract: A method of forming a RuSi film, the method includes adsorbing silicon in a recess that is formed in a substrate and includes an insulating film by supplying a silicon-containing gas to the substrate, forming a Ru film in the recess by supplying a Ru-containing precursor to the recess in which the silicon is adsorbed, and forming a RuSi film by supplying a silicon-containing gas to the recess in which the Ru film is formed.
    Type: Grant
    Filed: July 15, 2020
    Date of Patent: May 14, 2024
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Tadahiro Ishizaka, Naotaka Noro
  • Patent number: 11981993
    Abstract: A forming method of a component used in a plasma processing apparatus includes irradiating an energy beam to a source material of the component while supplying the source material based on a surface state of the component.
    Type: Grant
    Filed: May 10, 2019
    Date of Patent: May 14, 2024
    Assignee: TOKYO ELECTRON LIMITED
    Inventors: Michishige Saito, Kazuya Nagaseki, Shota Kaneko
  • Patent number: 11981994
    Abstract: The invention includes apparatus and methods for instantiating and quantum printing materials, such as elemental metals, in a nanoporous carbon powder.
    Type: Grant
    Filed: November 17, 2022
    Date of Patent: May 14, 2024
    Assignee: Quantum Elements Development Inc.
    Inventor: Christopher J. Nagel