Patents Issued in May 14, 2024
  • Patent number: 11982650
    Abstract: A method for testing an interfacial tribochemical reaction between a diamond wafer and active metal abrasive or metal oxide abrasive is provided. A surface of a diamond indenter used in a nano scratch tester is coated with a layer of the active metal abrasive or the metal oxide abrasive with uniform and controllable thickness by magnetron sputtering, and an interface interaction between the layer of the active metal abrasive or the metal oxide abrasive and the diamond wafer is controlled by a scratch test of the diamond wafer. Chemical components of an interaction section on a surface of the diamond wafer are analyzed by the scanning probe micro Raman spectrometer.
    Type: Grant
    Filed: August 7, 2023
    Date of Patent: May 14, 2024
    Assignee: HUAQIAO UNIVERSITY
    Inventors: Xipeng Xu, Jing Lu, Qiufa Luo, Yueqin Wu, Dekui Mu, Zhiping Xue
  • Patent number: 11982651
    Abstract: Method for adapting the concentration of a sample gas in a gas mixture to be analysed by a gas chromatograph assembly, the assembly comprising a sample gas inlet, a secondary gas inlet, a gas chromatograph sensor, a gas chromatograph column, and a gas chromatograph bypass parallel to the column, characterized by a) introducing sample gas through the sample gas inlet, b) introducing secondary gas through the secondary gas inlet, c) mixing the sample gas and the secondary gas to a gas mixture and conducting the mixture via the bypass, d) circulating the mixture in a gas conducting loop comprising the bypass and the sensor, e) repeating steps b), c) and d) without step a) to gradually reduce the concentration of sample gas within the mixture until the concentration reaches a desired predetermined level, f) analysing the mixture by means of gas chromatography employing the column and the sensor.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: May 14, 2024
    Assignee: INFICON GmbH
    Inventors: Johan Hellgren, Henrik Vennerberg
  • Patent number: 11982652
    Abstract: Disclosed are non-contiguous sample fractionating and concatenating device and a dual online multidimensional liquid chromatography system having the same. The non-contiguous sample fractionating and concatenating device according to an embodiment of the present disclosure includes a sample supply module which supplies a sample to be analyzed, and a sample fractionation module connected to the sample supply module, and which is continuously supplied with the sample, sets a plurality of unit sample supply times obtained by equally dividing a total sample supply time during which the sample is supplied from the sample supply module, sets a plurality of unit fractionation intervals obtained by equally dividing each of the plurality of unit sample supply times, and concatenates and stores the sample supplied during corresponding unit fractionation intervals within each unit sample supply time to acquire a plurality of fractions.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: May 14, 2024
    Assignee: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
    Inventors: Sang-Won Lee, Hangyeore Lee
  • Patent number: 11982653
    Abstract: First and second flow-path portions are opposite to each other, and communicate with each other such that a direction in which an eluent flows through the first flow-path portion and a direction in which an eluent flows through the second flow-path portion are opposite to each other. First and second electrode liquid flow paths are respectively opposite to the first and second flow-path portions. First and second electrode liquids are respectively supplied to the first and second electrode liquid flow paths, such that a direction in which the first electrode liquid flows through the first electrode liquid flow path is same as a direction in which an eluent flows through the first flow-path portion and a direction in which the second electrode liquid flows through the second electrode liquid flow path is same as a direction in which an eluent flows through the second flow-path portion.
    Type: Grant
    Filed: April 1, 2019
    Date of Patent: May 14, 2024
    Assignee: SHIMADZU CORPORATION
    Inventors: Katsumasa Sakamoto, Masanori Fujiwara
  • Patent number: 11982654
    Abstract: Determining a level of a liquid in a container is described. In one aspect, a container includes a calibrant liquid used for calibrating a mass spectrometer. A conductive layer is placed to float upon the calibrant liquid, and a circuit board with electrodes is arranged around the container. A controller circuit then drives and measures various electrodes to first identify which two electrodes the level of the calibrant liquid is between, and then subsequently identify a more precise location for the level between the two electrodes.
    Type: Grant
    Filed: November 4, 2021
    Date of Patent: May 14, 2024
    Assignee: Thermo Finnigan LLC
    Inventors: Raman Mathur, Thi Le, David E. Minkler
  • Patent number: 11982655
    Abstract: The present invention makes it possible to realize an analysis apparatus having a plurality of liquid chromatographs capable of judging separation performance and the like at the right timing and improving analysis performance early. Analysis starts and a mixed sample is prepared by adding a non-retaining ingredient to a measurement object sample and is introduced into an analysis flow path (S401 to S404). The mixed sample is separated into components by a separation column, the components are outputted as chromatogram data by a detector, and the analysis finishes (S404 to S406). Retention time and peak information are acquired from the chromatogram outputted from the detector, whether or not a measurement result is within an allowable range is judged, and the process shifts to next analysis when the measurement result is within the allowable range (S407 to S409).
    Type: Grant
    Filed: November 19, 2019
    Date of Patent: May 14, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Daisuke Akieda, Makoto Nogami, Iwao Suzuki, Masako Kawarai, Izumi Ogata, Shinya Ito
  • Patent number: 11982656
    Abstract: A method for controlling a mass spectrometer comprising a mass analyser and a detector. A test specimen is supplied into the mass analyser, to travel through the mass analyser and towards the detector, the test specimen comprising a carrier gas and/or analyte ions, the test specimen being one of a series of test specimens to be analysed. An ion intensity is measured, the ion intensity representing the intensity of ions within the test specimen received at the detector. The method determines if at least one validity criterion of a group of validity criteria is complied with, the group of validity criteria including: identification of a valid peak in the ion intensity measured within a predetermined time interval; and identification of a user-specified flag associated with the predetermined time interval. If none of the validity criteria are complied with, then terminating supplying into the mass analyser the test specimen and any further test specimen of the series of test specimens.
    Type: Grant
    Filed: September 8, 2021
    Date of Patent: May 14, 2024
    Assignee: Thermo Fisher Scientific (Bremen) GmbH
    Inventors: Holger Jeglinski, Frank-Torsten Heine
  • Patent number: 11982657
    Abstract: A method for calibrating at least one analytic device with repeated hardware components is disclosed and comprises providing at least one calibrator sample i having a known target value of a concentration of at least one analyte; at least one measuring step, wherein the measuring step comprises conducting at least one measurement on the calibrator sample using the analytic device, wherein at least one detector signal sijk is acquired; at least one calibration step, wherein a relationship between the detector signal and the concentration of the analyte and/or between the detector signal and a theoretical signal value is determined, wherein the calibration step comprises providing at least one parametrized function; determining calibration values by conducting a calibration based on the parametrized function; and determining an analysis function on basis of an inverse of the parametrized function and the determined calibration values.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: May 14, 2024
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Nadja Arens, Andrea Geistanger, Anton Hilger, Daniel Intelmann, Shirin Shahriari
  • Patent number: 11982658
    Abstract: Methods, apparatuses and systems for calibrating gas detectors are disclosed. An example calibration apparatus may have a gas supply element configured to provide a background gaseous substance within at least a portion of the calibration apparatus, a nebulizing element configured to generate the testing gaseous substance by transforming a testing solution in conjunction with the background gaseous substance, a pressure control element configured to regulate airflow in order to maintain a constant air pressure within the at least a portion of the calibration apparatus, and a controller component in electronic communication with the gas supply element, the nebulizing element and the pressure control element.
    Type: Grant
    Filed: June 1, 2022
    Date of Patent: May 14, 2024
    Assignee: Honeywell International Inc.
    Inventors: Xiangcai He, Chuang Huang, Li Liu, Yong Wang
  • Patent number: 11982659
    Abstract: A system for calibrating a moisture sensor encompasses a processing unit (341). The processing unit (341) includes a reference data obtaining LCKT (345), a subject data obtaining LCKT (346) and a relationship calculating LCKT (347). The reference data obtaining LCKT (345) obtains reference data, after injecting water-vapor with known concentrations into an analyzer. The subject data obtaining LCKT (346) measures subject data indicating temporal variation of output-responses of a subject sensor element of the analyzer under test. The relationship calculating LCKT (347) compares the subject data with the reference data, and calculates relationships between the output-responses of the subject sensor element and the known concentrations.
    Type: Grant
    Filed: August 9, 2021
    Date of Patent: May 14, 2024
    Assignee: Ball Wave Inc.
    Inventors: Takamitsu Iwaya, Shingo Akao, Tatsuhiro Okano, Nobuo Takeda, Toshihiro Tsuji, Toru Oizumi, Hideyuki Fukushi, Maki Sugawara, Yusuke Tsukahara, Kazushi Yamanaka
  • Patent number: 11982660
    Abstract: A quality control system analyzes the quality of a battery cell, with the battery cell defining a gas pouch configured to be filled with a gas. The quality control system includes a computational system including a processor and a memory, a manifold defining a passageway extending between an inlet port for receiving the gas and an outlet port, and at least one sensor in electronic communication with the computational system. The sensor is arranged to measure a physical property of the gas and transmit a signal to the computational system corresponding to the physical property of the gas. The computational system analyzes the physical property of the gas, accesses a threshold value corresponding to the physical property, compares the physical property to the threshold value, and assess a quality score for the battery cell. A corresponding method analyzes the quality of the battery cell with the quality control system.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: May 14, 2024
    Assignee: GM GLOBAL TECHNOLOGY OPERATIONS LLC
    Inventors: Raffaello Ardanese, James R. Salvador, Ryan Curtis Sekol, Thomas A. Yersak, Dmitriy Bruder
  • Patent number: 11982661
    Abstract: Techniques to suggest one or more sets of ingredients that can be used to recreate or mimic a target sensory description using artificial intelligence are disclosed. An artificial intelligence model includes a transformer inspired neural network architecture that learns from ingredients, recipes, and sensory profiles. The artificial intelligence model includes a sensory transformer model that generates a probability distribution of source ingredients based on an embedding associated with first digital data representing ingredients and the second digital data representing sensory description, and a selector that selects at least one candidate ingredient from the probability distribution of source ingredients for the embedding. A complete set of ingredients generated based on the at least one candidate ingredient when combined become a food product that has or achieves the sensory description.
    Type: Grant
    Filed: May 30, 2023
    Date of Patent: May 14, 2024
    Assignee: Notco Delaware, LLC
    Inventors: Alonso Vargas Estay, Hojin Kang, Francisco Clavero, Aadit Patel, Karim Pichara
  • Patent number: 11982662
    Abstract: The present disclosure discloses a marker for screening and distinguishing NFC apple juice based on non-targeted metabolomics and use thereof, relating to the technical field of distinguishing of juice. The marker for distinguishing NFC apple juice disclosed in the present disclosure is selected from the following molecules: gallocatechin, catechin, taxifolin, p-hydroxybenzaldehyde, 5-methoxysalicylic acid, azelaic acid, caffeic acid, chlorogenic acid, epicatechin, eriodictyol, ferulic acid, isoquercitrin, naringenin, n-fructosyl isoleucine, p-coumaraldehyde, p-coumaric acid, phloretin, phlorizin, procyanidin B1, quercetin-3-O-galactoside and rutin. The above markers may be used for distinguishing the NFC apple juice and the FC apple juice, and have relatively high accuracy.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: May 14, 2024
    Inventors: Zhenzhen Xu, Lei Xu, Jiming Zhang, Chuanzhu Leng, Xue Wang, Kewen Wang, Gang Xin, Xinfei Song
  • Patent number: 11982663
    Abstract: The method can include analyzing the composition of the particulate polymer debris, including ascertaining a presence of at least one main polymer element and a presence or absence of at least one signature polymer element in the particulate debris; establishing a correlation between the particulate polymer debris and a set of components, including matching the ascertained presence of the at least one main polymer element to a family of polymers from which the components of the set, including the source component, are made; and determining the source component amongst the components of the set, including matching the ascertained presence or absence of the at least one signature polymer element to a polymer composition of the source component.
    Type: Grant
    Filed: July 19, 2022
    Date of Patent: May 14, 2024
    Assignee: PRATT & WHITNEY CANADA CORP.
    Inventor: Louis Brillon
  • Patent number: 11982664
    Abstract: The present application provides a true three-dimensional dynamic and static combination shear device under high-temperature, high pore pressure and chemical coupling and a method therefor, specifically designed for the rock indoor loading test technical field. The device includes a hydraulic system, a pore pressure coupling system, an annular frame, a frame base, a lateral horizontal support platform, a lateral floating frame, a normal dynamic and static combination loading cylinder, a lateral dynamic and static combination loading cylinder, a tangential hydrostatic loading cylinder, a tangential disturbance loading cylinder, a high-temperature box, and a true three-dimensional high-temperature, high pore pressure and chemical coupling shear box.
    Type: Grant
    Filed: February 7, 2024
    Date of Patent: May 14, 2024
    Inventors: Zhi Zheng, Guoshao Su, Cao Luo, Quan Jiang
  • Patent number: 11982665
    Abstract: A sensor for monitoring the quality of oil in mechanical machinery is provided. The sensor includes a portion that is sealed from the oil which contains electric circuitry to process signals received from the sensing elements. Another portion of the sensor is exposed to the oil and contains one or more sensing elements to sense one or more properties of the oil. The sensed properties may include electrical properties, temperature properties and/or optical properties.
    Type: Grant
    Filed: November 20, 2020
    Date of Patent: May 14, 2024
    Assignee: Dodge Industrial, Inc.
    Inventors: Erald Pjetri, Stefan Pypec, Artur Rdzanek, Brandon LeRoy, Greg Hewitt, Isaac O'Brien-Herr
  • Patent number: 11982666
    Abstract: A system and method for the real-time monitoring and updating of a prediction of concrete drying is disclosed. The system includes one or more sensors positioned inside a concrete slab and one or more sensors positioned outside the concrete slab. Each sensor positioned inside and outside the concrete slab to transmit data to a cloud-based web portal configured to transmit a prediction to a computing device.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: May 14, 2024
    Assignee: eGate Smart Building Innovation Oy
    Inventor: Lari Maasalo
  • Patent number: 11982667
    Abstract: Provided is a platelet aggregation capacity analyzer including a blood coagulation system-analyzing unit that analyzes a platelet aggregation capacity based on measurement data during a coagulation process of a platelet-containing sample, and an output control unit that controls an output of results analyzed by the blood coagulation system-analyzing unit, in which the blood coagulation system-analyzing unit analyzes the platelet aggregation capacity of the platelet-containing sample based on the barb of measurement data during the coagulation process with a platelet aggregation inhibitor added to the platelet-containing sample and measurement data during the coagulation process without a platelet agonist or the platelet aggregation inhibitor added to the platelet-containing sample.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: May 14, 2024
    Assignee: SONY CORPORATION
    Inventors: Aya Fuchigami, Seungmin Lee, Yoshihito Hayashi, Kenzo Machida
  • Patent number: 11982668
    Abstract: Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of assessing the effect of an agent on renal function, the method comprising contacting the agent with a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are models of renal disorder. In one embodiment, disclosed are models of renal fibrosis, comprising a three-dimensional, engineered, bioprinted, biological renal tubule model. Also disclosed are methods of making the model of renal disorder. In one embodiment disclosed are methods of making the model of renal fibrosis comprising contacting a three-dimensional, engineered, bioprinted, biological renal tubule model with an agent that is capable of inducing interstitial fibrotic tissue formation.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: May 14, 2024
    Assignee: Organovo, Inc.
    Inventors: Shelby Marie King, Deborah Lynn Greene Nguyen, Sharon C. Presnell
  • Patent number: 11982669
    Abstract: A flow test unit (1) with a housing (2) which is sealingly closed to the outside at least when coupled to a sample container. At least one test strip (3) is accommodated in the housing (2), and the housing (2) has at least one admission opening (4). The test strip (3) is arranged inside the housing (2) such that, after a liquid connection (22) to a sample container has been produced, a wetting region (5) can be wetted with liquid (6) entering via the at least one admission opening (4).
    Type: Grant
    Filed: June 25, 2020
    Date of Patent: May 14, 2024
    Assignee: Testo SE & Co. KGAA
    Inventors: Martin Strnad, Andreas Schnur, Joel Riemer, Oliver Wiech
  • Patent number: 11982670
    Abstract: Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response during intravenous PEGylated uricase therapy in gout patients is provided. Routine SUA monitoring can be used to identify patients receiving PEGylated uricase who may no longer benefit from treatment and who are at greater risk for infusion reactions.
    Type: Grant
    Filed: February 1, 2023
    Date of Patent: May 14, 2024
    Assignee: Horizon Therapeutics USA, Inc.
    Inventors: Theresa Rosario-Jansen, David Erick Wright
  • Patent number: 11982671
    Abstract: Disclosed herein are methods of diagnosing Rheumatoid arthritis in a subject comprising determining whether the subject is immunologically reactive with P. copri or a portion thereof. In one aspect of the invention the immunological reactivity of the subject to one or more protein of P. copri or polypeptide fragments thereof such as protein Pc-p27 or polypeptide fragments thereof, as compared to an appropriate control, indicates the subject has rheumatoid arthritis. Examples of specific assays, compositions, and kits for use with the methods are also disclosed.
    Type: Grant
    Filed: December 9, 2020
    Date of Patent: May 14, 2024
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Allen C. Steere, Elise E. Drouin
  • Patent number: 11982672
    Abstract: The present invention relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta constant region 1 (TRBC1) or TRBC2; cells; such a T cells comprising such a CAR; and the use of such cells for the treatment of a T-cell lymphoma or leukaemia in a subject.
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: May 14, 2024
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Paul Maciocia
  • Patent number: 11982673
    Abstract: The present invention relates to a chimeric antigen receptor (CAR) which comprises an antigen-binding domain which selectively binds TCR beta constant region 1 (TRBC1) or TRBC2; cells; such a T cells comprising such a CAR; and the use of such cells for the treatment of a T-cell lymphoma or leukaemia in a subject.
    Type: Grant
    Filed: June 3, 2022
    Date of Patent: May 14, 2024
    Assignee: AUTOLUS LIMITED
    Inventors: Martin Pulé, Paul Maciocia
  • Patent number: 11982674
    Abstract: In some embodiments, a mass spectrometry tag may comprise a linker region, a mass balance region, and a reporter region. The mass spectrometry tag may be configured to fragment in a mass spectrometer via an energy dependent process to produce multiple reporter molecules. For example, the reporter region of the tag may be configured to produce at least two reporter molecules via fragmentation. In some embodiments, one or more regions of the tag may comprise at least one heavy isotope. In some such embodiments, the ability to fragment into multiple reporter molecules as well as the placement and/or number of heavy isotope(s) allows the mass spectrometry tag to be distinguished from other similar mass spectrometry tags. In some such embodiments, the ability to distinguish between tags having the same or substantially similar total mass to charge ratio and reporter region mass may allow the system to have a greater multiplexing capacity than conventional systems.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: May 14, 2024
    Assignees: President and Fellows of Harvard College, Dana-Farber Cancer Institute, Inc.
    Inventors: Craig Braun, Wilhelm Haas, Steven P. Gygi, Gregory H. Bird, Loren D. Walensky, Martin Helmut Wuhr, Brian K. Erickson
  • Patent number: 11982675
    Abstract: ABC multidrug transporters are key players in cancer multidrug resistance and in general xenobiotic elimination, thus their functional assays provide important tools for research and diagnostic applications. It has been found that in cells expressing functional ABCG2, ABCB1, or ABCC1 transporters, cellular PG fluorescence is strongly reduced. The invention relates to methods and uses of fluorescein derivative ester compounds of formula Ia which are analogs of PG for assessing ABC transporter activity of ABC multidrug transporters. The present accumulation assay is a novel tool for the parallel determination of the function of the multidrug transporters, in particular ABCG2, ABCB1, and ABCC1. The assay is applicable for diagnostic purposes and also allows the selection, separation and culturing of selected cell populations expressing such transporters.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: May 14, 2024
    Assignees: CELLPHARMA KFT., TERMÉSZETTUDOMÁNYI KUTATÓKÖZPONT
    Inventors: Edit Szabó, Dóra Kovács-Türk, Ágnes Telbisz, Nóra Kucsma, Tamás Horváth, Gergely Szakács, László Homolya, Balázs Sarkadi, Várady György
  • Patent number: 11982676
    Abstract: A fluorescent probe having a capsule of nanometric size and an aggregate of fluorogenic molecules coupled to the capsule is provided. The aggregate emits a fluorescent signal at one or more wavelengths within the fluorescence spectral range when the probe is illuminated by an excitation light beam at one or more wavelengths within the excitation spectral range. Preferably, the fluorescent spectral range is in the near-infrared region of the spectrum. In some embodiments, the capsule is a boron nitride (BN) nanotube and the aggregate comprise 3,6-Bis[2,2?]bithiophenyl-5-yl-2,5-di-n-octylpyrrolo[3,4-c]pyrrole-1,4-dione as fluorogenic molecules. In some embodiments, the 3,6-Bis[2,2?]bithiophenyl-5-yl-2,5-di-n-octylpyrrolo[3,4-c]pyrrole-1,4-dione fluorogenic molecules are in a J-aggregation state.
    Type: Grant
    Filed: April 16, 2021
    Date of Patent: May 14, 2024
    Assignees: VALORISATION-RECHERCHE, LIMITED PARTNERSHIP, POLYVALOR, LIMITED PARTNERSHIP, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Richard Martel, Étienne Gaufrès, Charlotte Allard
  • Patent number: 11982677
    Abstract: The present disclosure relates to compositions of matter and assay methods used to screen for molecular dimerization events using a two-ribonucleoprotein complex signal boost assay. The compositions and methods provide a readout upon detection of dimerization of molecules and may be implemented in a high throughput manner using libraries of tens to hundreds to thousands of putative binding partners.
    Type: Grant
    Filed: September 23, 2023
    Date of Patent: May 14, 2024
    Assignee: VedaBio, Inc.
    Inventor: Daniel Durocher
  • Patent number: 11982678
    Abstract: Provided herein, among other aspects, are methods and apparatuses for ranking aliquots from a suspension containing bioparticles. In certain embodiments, the bioparticles may be cells, organelles, proteins, DNAs, debris of biological origin, microbeads coated with biological compounds, or viral particles. As such, the methods and apparatuses provided herein may be used to quantify rare cells such as circulating cancer cells, fetal cells and other rare cells present in bodily fluids for disease diagnosis, prognosis, or treatment.
    Type: Grant
    Filed: October 26, 2018
    Date of Patent: May 14, 2024
    Assignee: UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION
    Inventors: Daniel T. Chiu, Perry G. Schiro, Jason S. Kuo
  • Patent number: 11982679
    Abstract: The present invention relates to a method for obtaining protein mimotopes occurring in at least two distinct 3D conformations. In a further embodiment, a method for detecting antibodies with diagnostic relevance using said mimotopes is claimed. In a preferred embodiment, said methods are applied to Alzheimer's disease.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: May 14, 2024
    Assignee: DISTRETTO TECNOLOGICO SICLILIA MICRO E NANO SISTEMI S.C.A.R.L.
    Inventors: Salvatore Guglielmino, Laura Maria De Plano, Santina Carnazza, Domenico Franco, Alessandra Nicoletti, Mario Zappia, Sabrina Conoci, Salvatore Petralia
  • Patent number: 11982680
    Abstract: Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.
    Type: Grant
    Filed: December 9, 2022
    Date of Patent: May 14, 2024
    Assignee: Jana Care, Inc.
    Inventors: Daniel B. Lookadoo, Ashok A. Kumar, Jeremy E. Schonhorn, Christopher M. Uherek, Michal Depa
  • Patent number: 11982681
    Abstract: Provided is an electrolyte analyzing device in which contamination caused by contacting different reagents with a suction nozzle is prevented when reagent replacement is performed by a user. The electrolyte analyzing device includes a reagent container setting unit 502 that sets a dilute solution bottle 101-1 which houses a dilute solution, an internal standard solution bottle 101-2 which houses an internal standard solution, and a reference electrode solution bottle 101-3 which houses a reference electrode solution. The reagent container setting unit includes a partition wall between the dilute solution bottle 101-1 and the internal standard solution bottle 101-2, and the reference electrode solution bottle 101-3 when the dilute solution bottle 101-1, the internal standard solution bottle 101-2, and the reference electrode solution bottle 101-3 are set.
    Type: Grant
    Filed: March 26, 2019
    Date of Patent: May 14, 2024
    Assignee: HITACHI HIGH-TECH CORPORATION
    Inventors: Takushi Miyakawa, Masaki Hara, Tetsuji Kawahara
  • Patent number: 11982682
    Abstract: A hand-portable test apparatus includes an in-the-field test processing assembly, and a lab-on-a-chip test cartridge having a neutralising zone, a specific reagent mixing zone, and a testing chamber. It has a convective heating loop for thermal cycling. There are two passive self-actuating valves that allow the test chamber volume to fill with solution, but then close to meter and trap the solution. The apparatus has external illumination ports, and an optical sensing port. Each cartridge is uniquely identified. It has smooth surfaces that allow adhesive membranes to be used to permit the pre-loading of reagents, prevent evaporation, and permit preservation of results. The test apparatus includes a holder for the cartridge with a heater, illumination, and optical sensor units closely positioned relative to the holder. There is a wiring circuit board, a processor, and a power supply. All of the items are contained within a unitary housing.
    Type: Grant
    Filed: May 6, 2020
    Date of Patent: May 14, 2024
    Assignee: University of Prince Edward Island
    Inventor: Andrew Trivett
  • Patent number: 11982683
    Abstract: A system for detecting bubbles and clogs by differentiating between the two instances through the observance of a pressure differential range over a specific time in an interior of a pipe having a liquid flow. The system utilizes a pressure sensor and a microcontroller communicating with the sensor to gather pressure readings to determine which one of the two scenarios are present when a pressure drop happens, through determining whether the pressure differential range over a specific time is exceeding a predetermined threshold or not. The microcontroller is configured to determine that when gathered pressure readings fall below a selected minimum acceptable pressure level and the pressure differential range is exceeded for a specific time, bubbles are present in the liquid flowing in the pipe while the microcontroller is also configured that when the pressure differential range is not exceeded with a pressure drop, that a clog is present.
    Type: Grant
    Filed: May 20, 2022
    Date of Patent: May 14, 2024
    Inventor: Mehmet Arbatli
  • Patent number: 11982684
    Abstract: Systems, methods and programs are provided for automated science experiments which use a model with learnt model parameters to define points for physical-characteristic measurements once the model is trained. The systems, methods and programs use active learning which enables describing a relationship between local features of sample-surface structure shown in image patches and determined representations of physical-characteristic measurements.
    Type: Grant
    Filed: May 26, 2023
    Date of Patent: May 14, 2024
    Assignee: UT-Battelle, LLC
    Inventors: Maxim A. Ziatdinov, Kevin Roccapriore, Yongtao Liu, Kyle P. Kelley, Rama K. Vasudevan, Jacob D. Hinkle, Sergei V. Kalinin
  • Patent number: 11982685
    Abstract: The present disclosure generally pertains to testing of secondary batteries. More specifically, the disclosure relates to a movable walk-in chamber for testing secondary cells. According to a first aspect, the present disclosure relates to a movable walk-in chamber for testing secondary cells comprising an enclosure, racking, a plurality of cycler interfaces and cabling. The enclosure form at least one thermally isolated temperature chamber. Furthermore, the enclosure comprises a walking aisle arranged between an entrance and an exit. The racking is arranged at inner walls of the enclosure along the walking aisle. Secondary cells can be inserted in the racking for testing and removed after testing. The plurality of cycler interfaces are arranged at outer walls of the enclosure. Each cycler interface comprises a power interface and one or more cell interfaces.
    Type: Grant
    Filed: December 1, 2022
    Date of Patent: May 14, 2024
    Assignee: Northvolt AB
    Inventor: Sean Stephenson
  • Patent number: 11982686
    Abstract: Disclosed is an electrode lead gripper for a pressure activation device, and, in particular, an electrode lead gripper for a pressure activation device in which a current electrode terminal is configured to be stacked and mounted onto an electrode terminal base separately from a voltage electrode terminal and thus improved in contact reliability and increased in contact area in terms of contact with an electrode lead of a pouch type battery cell, thereby having advantages of decreasing contact resistance, reducing the amount of heat generated during charging/discharging, and resulting in further enhancing a charging/discharging efficiency.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: May 14, 2024
    Assignee: APRO CO., LTD
    Inventor: Jong Hyun Lim
  • Patent number: 11982687
    Abstract: The present disclosure relates to an IC chip holder capable of alleviating an impact if the IC chip holder is dropped or collides with another object. In the IC chip holder, an upper housing body is provided, on a side of electric contacts of an IC chip, with an elastic deformation portion capable of elastically deforming toward the inside of the upper housing body. Thus, since the elastic deformation portion elastically deforms toward the inside of the upper housing body, if the IC chip holder is dropped or collides with another object, the elastic deformation portion bends and the impact is alleviated. Thus, a possibility of the IC chip being damaged is reduced.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: May 14, 2024
    Assignee: BROTHER KOGYO KABUSHIKI KAISHA
    Inventors: Hidekazu Komiya, Koji Hayashi
  • Patent number: 11982688
    Abstract: The present invention relates to a test socket having a thin structure that can reduce durability degradation of a contact itself, have excellent electrical characteristics in processing high-speed signals, and can extend a service life thereof, and relates to spring contacts suitable thereto. The test socket according to the present invention includes: a plurality of spring contacts (100) each of which includes an upper contact pin (110) and a lower contact pin (120) that are assembled cross each other, and a spring (130) supporting the upper and lower contact pins (110 and 120); a main plate (1110) having a plurality of accommodating holes (1111) in which the respective spring contacts (100) are accommodated, with first openings (1113); and a film plate (1120) provided on a lower portion of the main plate (1110), and having second openings (1121).
    Type: Grant
    Filed: October 25, 2022
    Date of Patent: May 14, 2024
    Assignee: HICON CO., LTD.
    Inventors: Dong Weon Hwang, Logan Jae Hwang, Jae Baek Hwang
  • Patent number: 11982689
    Abstract: Embodiments are directed to microscale and millimeter scale multi-layer structures (e.g., probe structures for making contact between two electronic components for example in semiconductor wafer, chip, and electronic component test applications). One or more layers of the structures include shell and core regions formed of different materials wherein the core regions are offset from a symmetric, longitudinally extending position.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: May 14, 2024
    Assignee: Microfabrica Inc.
    Inventor: Garret R. Smalley
  • Patent number: 11982690
    Abstract: A method, a system, and a non-transitory computer readable medium for detecting time difference include a transmitting device and a receiving device being in time synchronization; an oscilloscope detecting a time difference generated thereof to obtain a first time difference; the transmitting device generating a first system time, based on the first system time, generating a first image, and transmitting the first image to a display to generate a second time difference; an image capturing device obtaining the first image from the display and generating a first signal, to generate a third time difference; the receiving device receiving the first signal to generate a fourth time difference, and obtaining the first system time according to the first signal and generating a second system time when obtaining the first system time, and to generate a fifth time difference.
    Type: Grant
    Filed: August 15, 2022
    Date of Patent: May 14, 2024
    Assignee: Fulian Precision Electronics (Tianjin) Co., LTD.
    Inventor: Po-Hui Lu
  • Patent number: 11982691
    Abstract: A measuring apparatus for measuring an electrical voltage for a metal-encapsulated switchgear. The measuring apparatus has an electrical conductor, an electrically conductive measuring electrode, which surrounds a first conductor portion of the electrical conductor and is electrically insulated from the electrical conductor, and an electrically conductive field control electrode, which is electrically insulated from the electrical conductor and from the measuring electrode and which has a first field control electrode portion that surrounds the measuring electrode.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: May 14, 2024
    Assignee: Siemens Energy Global GmbH & Co. KG
    Inventors: Stefan Giere, Thomas Heinz, Thomas Hilker
  • Patent number: 11982692
    Abstract: An apparatus for identifying a fault in the windings of a distribution transformer, a transformer, and an associated method, said device comprising: a first Rogowski current sensor at a high-voltage incoming current terminal, and a second Rogowski current sensor in tandem at a low-voltage outgoing current terminal and at a low-voltage incoming current terminal; a first conductor of the low-voltage outgoing current terminal, passed through in one direction through the second sensor, and a second conductor of the low-voltage incoming current terminal, passed through in the opposite direction through the second sensor; the first and second sensors generate output signals indicating the primary current and the secondary current; both signals are integrated, generating output signals proportional to the primary current and the secondary current, obtaining a transformation ratio, which is compared with a threshold, and sending a fault signal if said threshold is exceeded.
    Type: Grant
    Filed: November 9, 2020
    Date of Patent: May 14, 2024
    Assignee: PROLEC, S. A. DE C. V.
    Inventors: Juan Angel Barrientos Torres, Berenice Bahena De Leon
  • Patent number: 11982693
    Abstract: Apparatuses and methods of the present disclosure integrate a non-intrusive current sensor in the form of a current mismatch sensor into a power module having paralleled semiconductor structures or components. The current mismatch can be detected by the current sensor by monitoring a magnetic flux density between the paralleled components or devices.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: May 14, 2024
    Assignee: The University of North Carolina at Charlotte
    Inventors: Babak Parkhideh, Andreas Lauer
  • Patent number: 11982694
    Abstract: An electronic device and method for operating the same are provided. The electronic device includes a connector, a first measuring unit, a power source, and a switching unit. The switching unit is configured to switch the electronic device between a first operation mode and a second operation mode. When the first operation mode is selected, the first measuring unit is configured to be electrically coupled between the power source and the connector so as to measure a first electrical signal communicated between the power source and the connector.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: May 14, 2024
    Assignee: MGL GLOBAL SOLUTIONS LIMITED
    Inventors: David Barden, Danny Swerkes
  • Patent number: 11982695
    Abstract: A transformer area identification method determines a corresponding electric meter mounting relationship by identifying a power jump characteristic based on a power statistic of each node in a power supply network of a transformer area, thereby eliminating the influence of line loss power and increasing identification accuracy. In addition, the identification is performed based on change characteristics of unidentified total power and power of an electric meter in a to-be-identified domain, to reduce interference of a power fluctuation of an identified electric meter to the identification and increase the identification accuracy. Moreover, iterative identification is used, so that the to-be-identified domain is smaller and a convergence speed is faster. The transformer area identification method uses a power jump algorithm to identify the transformer area, thereby eliminating the influence of the line loss power and increasing the identification accuracy.
    Type: Grant
    Filed: April 20, 2020
    Date of Patent: May 14, 2024
    Assignee: BEIJING TENGINEER AIOT TECH CO., LTD.
    Inventors: Hongshan Chang, Guang He
  • Patent number: 11982696
    Abstract: A system includes an orthogonal coordinate signal generator that generates an orthogonal two-phase voltage signal from a three-phase voltage signal of three-phase alternating current power of a power system; and a frequency calculator including an angular frequency calculator calculating an angular frequency of the power system based on the two-phase voltage signal, and an arithmetic unit calculating a system frequency of the power system from the angular frequency. A prediction calculator calculates a predicted value of the angular frequency after a time has elapsed based on the angular frequency and a differential of the angular frequency. In a state in which the phase jump of the power system is not detected, the frequency calculator calculates the system frequency based on the angular frequency. When the phase jump of the power system is detected, the frequency calculator calculates the system frequency based on predicted value for a constant amount of time.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: May 14, 2024
    Assignee: TOSHIBA MITSUBISHI-ELECTRIC INDUSTRIAL SYSTEMS CORPORATION
    Inventors: Yasuaki Mitsugi, Takashi Shigemasa
  • Patent number: 11982697
    Abstract: The application discloses a RF vector measurement system including: a first port for generating a RF pulse, a pulse splitter for splitting the pulse into a first pulse send to a device-under-test DUT, and a second pulse send as a reference to a first quantum sensor of the system. The system is arranged to supply a third pulse, which is produced by reflecting or transmitting the first by the DUT, to at least one second quantum sensor phase-correlated with said first quantum sensor by entanglement.
    Type: Grant
    Filed: December 23, 2021
    Date of Patent: May 14, 2024
    Assignee: Rohde & Schwarz GmbH & Co. KG
    Inventor: Julius Seeger
  • Patent number: 11982698
    Abstract: A feature detection system, the system comprising: at least one processor in operative communication with a signal source, said processor further comprising at least one non-transitory storage medium, wherein at least one non-transitory storage medium contains instructions configured to cause the processor to: apply a joint group sparse denoising and delay estimation approach to a signal received from said signal source; and output statistics regarding the signal, wherein the joint group sparse denoising and delay estimation approach comprises; using the following equation: { x * , ? * } = argmin x , ? ? { 1 2 ? ? j = 1 M ? y j - x ? 2 2 + ? i = 0 N ? i ? ? i ( D i l i ? x ) } where: ?i are regularization functions; ?y?x?22 is a data-fidelity term and, in embodiments, is chosen as the least-square term; li are real numbers; Di are operators, which may be linear filters that can be written in matrix form; ?i are regularization parameters; and x*
    Type: Grant
    Filed: December 21, 2020
    Date of Patent: May 14, 2024
    Assignee: BAE Systems Information and Electronic Systems Integration Inc.
    Inventor: Masoud Farshchian
  • Patent number: 11982699
    Abstract: A system and method for testing devices such as integrated circuits (IC) with integrated antenna arrays configured for wireless signal reception. The method performs a calibration operation on a reference device under test (DUT). During the calibration operation, the DUT receives a series of first signals from a first far-field (FF) location and a series of array transmissions from a second near-field (NF) location using different beamforming settings, and determines therefrom a set of calibration parameters. The calibration parameters may be used by a probe antenna system (PAS) to transmit an array transmission to the DUT from the second NF location to emulate a single probe or multi-probe transmission from the first FF location.
    Type: Grant
    Filed: November 22, 2021
    Date of Patent: May 14, 2024
    Assignee: National Instruments Corporation
    Inventors: Martin Obermaier, Martin Laabs, Dirk Plettemeier, Marc Vanden Bossche, Thomas Deckert, Vincent Kotzsch, Johannes Dietmar Herbert Lange