Abstract: The present invention relates to a method of producing an immunoligand/payload conjugate, which method encompasses conjugating a payload to an immunoligand by means of a sequence-specific transpeptidase, or a catalytic domain thereof (Fig. 6b).

Abstract: The present invention provides a compound for the sequestration of undesirable antibodies (e.g. related to an autoimmune disease) in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P(—S—P)(n-1) and a second peptide n-mer of the general formula P(—S—P)(n-1); wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an immune reaction to a treatment with an active agent.

Abstract: Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload promotes the expression or activity of a functional dystrophin protein. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide, e.g., an oligonucleotide that causes exon skipping in a mRNA expressed from a mutant DMD allele.

Abstract: The presently disclosed subject matter relates to immunoswitch particles that switch off immunosuppressive pathways on tumor cells or immunosuppressive molecules induced by tumor cells in the tumor microenvironment, or virus infected cells or immunosuppressive molecules induced by virus infected cells in the microenvironment surrounding the virus infected cells, while simultaneously switching on co-stimulatory or co-inhibitory pathways on T cells, as well as method for converting immunosuppressive signals in cells, tissues, and subjects into stimulatory signals, and immunotherapy-based methods for treating cancer and chronic viral infections.

Abstract: A composition is configured to be administered to a subject undergoing a malignant lesion resection procedure. The composition comprises a pharmaceutically effective amount of pafolacianine or a pharmaceutically acceptable salt thereof. The pafolacianine or a pharmaceutically acceptable salt thereof is configured to bind one or more malignant lesions and emit an optical signal.

Abstract: A method for treating melanoma or preventing the development of melanoma comprising administration of a composition comprising 64Zne(Asp)2 in a therapeutically effective amount. Such administration may be via injection such as intratumoral and/or intravenous injection and may be once a day or more than once a day. A composition for the treatment of or prevention of melanoma comprising 64Zne(Asp)2 in a therapeutically effective amount. The composition may be a liquid suitable for injection.

Abstract: Described herein is a hair care composition including from about 0.01% to about 20% of a lipid being one or more unsaturated fatty materials chosen from unsaturated fatty acids, unsaturated fatty alcohols, and mixtures thereof. The unsaturated fatty material has a Log P of less than 8. The hair care composition also includes from about 0.01% to about 10% of a fatty acid monoester of a polyol, a saturated fatty alcohol, an ester of a saturated fatty alcohol, and mixtures thereof. The molecule of the fatty acid component of the fatty acid monoester includes a linear or a branched carbon chain with 10 to 22 carbon atoms. The fatty acid monoester of a polyol has a log P of less than 8. The molecule of the fatty alcohol includes a linear or branched carbon chain with 8 to 22 carbon atoms. The hair care composition also includes a non-aqueous volatile solvent.

Abstract: A rinse-off cleansing composition with improved viscosity. The rinse-off cleansing composition contains a surfactant system with an anionic surfactant, an amphoteric surfactant, and a non-ionic surfactant.

Abstract: The present invention is directed to previously identified inhibitors of cAMP efflux (ICE) and their use in treating/masking body odor, inhibiting, reducing and/or eliminating hyperhidrosis (excessive sweating), tanning skin or protecting skin before and/or after exposure to the sun as well as for treating certain skin conditions, in one embodiment, the invention provides a method for inhibiting body odor, a condition that is characterized by an unpleasant odor from the products of the microbial sweat degradation. By inhibiting the efflux of the precursor compounds that are degraded, novel compounds are capable of preventing unwanted odors. Deodorant compositions that employ this new approach for the control of bodily odor are provided, ICE compounds can also be used as components, of cosmetic formulations including tanning and after-sun formulations, formulations for skin conditions as described herein and other cosmetic formulations.

Abstract: A fusion protein according to an embodiment of the present disclosure includes a growth differentiation factor 11 and an epidermal growth factor with an enhanced anti-oxidation activity and an enhanced skin cell proliferation effect, A cosmetic composition according to an embodiment of the present disclosure includes the fusion protein as an effective component. The cosmetic composition can be advantageously used in future as a material of a functional cosmetic product.

Abstract: A dextrin fatty acid ester is provided in which the dextrin has an average degree of glycopolymerization of 3 or more and 100 or less. The fatty acid comprises one or more linear saturated fatty acids having 14 or more and 18 or less carbon atoms, and one or more branched saturated fatty acids having 14 or more and 18 or less carbon atoms. The molar fraction of the linear saturated fatty acid in the fatty acid is 0.75 or more and 0.95 or less. The average degree of substitution of the fatty acid per glucose unit is 1.5 or more and 2.0 or less.

Abstract: The present disclosure relates to cosmetic compositions comprising an uncured silicone based polymer. In particular, the present disclosure relates to cosmetic compositions comprising an uncured silicone based polymer; and at least one cosmetic ingredient, optionally in a cosmetically acceptable medium. The present disclosure also relates to preparation methods and uses of the cosmetic compositions.

Abstract: An anhydrous topical composition provides a water repellent surface. The anhydrous topical composition has at least one film former with surface tension lower than 35 dynes/cm, at least one particle having a hydrophobic surface or a hydrophobic surface treatment, and a volatile topical carrier.

Abstract: A method for treating human keratin fibers such as the hair is described and comprises the application to the keratin fibers of a dye composition comprising at least one silicone acrylic copolymer and at least one pigment, optionally the application of heat to the dyed keratin fibers using a heating tool and the application to the dyed keratin fibers of a makeup-removing composition comprising at least one hydrocarbon oil.

Abstract: A lip composition. The lip composition may include at least 40% by weight of one or more emollients, at least 20% by weight of waxes, the waxes including a hard wax and a soft wax, and a plurality of fillers including silica silylate and cellulose. The lip composition may be free of water and silicones, and may be vegan. The lip composition preferably includes no more than 6% by weight of fillers, and preferably includes no more than about 3% by weight of colorants.

Abstract: A toothpaste product that is laced with, or infused with, a sedative such as the active ingredients in cannabis. The act of brushing one's teeth using the present invention transfers the sedative into the bloodstream through contact with the gums, leading to a more restful sleep.

Abstract: A cosmetic active principle including a hydrolysate of Pichia minuta comprising at least peptides. Additionally, the use of the cosmetic active principle including a hydrolysate of Pichia minuta comprising at least peptides for controlling hair loss and stimulating regrowth. Also, compositions containing same and a cosmetic hair treatment method.

Abstract: The invention relates to the technical field of medicines, and particularly relates to a multi-component injection and preparation processes and applications thereof. In the present invention, the effective ingredients of safflower Carthamus, Red Paeony Root, Ligusticum wallichii, Radix salvia miltiorrhizae and Angelica sinensis are analyzed and a multi-component injection is prepared via the modem pharmaceutical preparation technology. The study proves that the multi-component injection of the invention has therapeutic effects on Sepsis.

Abstract: An orally disintegrating dosage form of a proton pump inhibitor, methods for its production and use thereof are provided. The dosage form includes a plurality of pellets containing a proton pump inhibitor admixed with a disintegrant to afford rapid disintegration in the oral cavity after administration.

Abstract: A chewable pharmaceutical product comprises a matrix comprising: a binder, a bulking agent, a lubricant, a humectant, an emulsifier, and optionally a flavoring, wherein the binder comprises one or more maltitol syrups, which are present in the pharmaceutical product in an amount in the range of 60-70% by weight; and colesevelam hydrochloride.

Abstract: The present disclosure relates to compositions and methods for treating oral pain. The compositions disclosed herein may comprise a dissolvable carrier containing at least one active ingredient. In some embodiments, the active ingredients comprise guaiacol, eugenol, glycerin, menthol oil, peppermint oil, oregano oil, and/or cardamom oil. The methods disclosed herein comprise treating oral pain in a subject using the compositions disclosed herein, wherein such compositions are configured as a paste that can be molded on or about a surface exhibiting oral pain in a subject's oral cavity. Such compositions are resistant to the moist environment of the subject's oral cavity and provide rapid, effective pain relief in the subject.

Abstract: Provided is a method for preparing a drug loaded nanoparticle comprising: dissolving a macromonomer, a stabilizer and a crosslinker in a solvent to create a mixture; adding an initiator system to the mixture; dissolving a drug or combination of drugs in an organic phase containing the mixture; and recovering the drug loaded nanoparticle, a composition comprising the drug loaded nanoparticle prepared by the above method, and a method for treating cancer comprising administering the above composition to a subject in need thereof.

Abstract: The present invention relates to a drug delivery system, in particular for a controlled administration of one or more active pharmaceutical ingredients to a body, and further in particular for oral administration of one or more active pharmaceutical ingredients to a body. The system thereby comprises a base component soluble in body fluids and a separate first component soluble in body fluids. The first component thereby comprises a therapeutically effective amount of a first active pharmaceutical ingredient.

Abstract: The present invention relates to the field of coating pharmaceutical substrates. In particular, the invention relates to methods of coating of pharmaceutical substances, pharmaceutical ingredients or a blend of them. The invention also provides a method of making a pharmaceutical formulation which may be processed into a pharmaceutical dosage form, which utilizes solid pharmaceutical particles and a pharmaceutical formulation obtained by the method. The methods of the invention utilize atomic layer deposition technology. The novel methods allow difficult, moisture sensitive and electrically charged pharmaceutical substrates to be easily processable.

Abstract: The system invention describes a support and improved method of application and removal. The support, comprised of a network of flexible, non-porous, multi-lumen tubing interlaces at a plurality of junctions to form a lattice structure. Apertures designed to accommodate boney prominences also permit air or water to reach the skin underneath and encourage rapid fluid flow internally through the lattice. A hydrophobic, thermal-resistant, flowable padding layer is injected within a secondary lumen to the lattice structure, spanning its complete surface area. As a result, the breathability of the support is not affected by this padding layer because it mirrors the apertures of the lattice. At least one liquid is injected into the structure and configured to transform into a solid when acted on by an external mechanical stimulus.

Abstract: In one aspect, compositions and wound dressings are described herein. In some embodiments, a composition or wound dressing described herein comprises a mesh formed from a plurality of biodegradable polymer fibers; a first active agent dispersed in the biodegradable polymer fibers; a plurality of biodegradable polymer particles disposed in the mesh; and a second active agent dispersed in the biodegradable polymer particles. The particles can be disposed within the interiors of the fibers of the mesh or between the fibers of the mesh. In another aspect, a composition or wound dressing described herein comprises a first perforated mesh formed from a first plurality of biodegradable polymer fibers; and a second perforated mesh formed from a second plurality of biodegradable polymer fibers, wherein the second perforated mesh is disposed on the first perforated mesh in a stacked configuration and the first and second perforated meshes have different degrees of perforation.

Abstract: Disclosed herein are composite materials, ionic liquid compositions for preparing the composite materials, and methods for using the composite materials prepared from the ionic liquid compositions. The composite materials typically include structural polymers and nitric oxide releasing agents, and preferably photo-reactive nitric oxide releasing compounds or complexes. The composite materials may be prepared from ionic liquid compositions comprising the structural polymers and the nitric oxide releasing agent, where the ionic liquid is removed from the ionic liquid compositions to obtain the composite materials. The composite materials may be used in applications include dressing for wounds, where the nitric oxide releasing agents may be induced to release nitric oxide in order to inhibit microbial growth and promote healing.

Abstract: A portable, handheld light sanitizer (10) having a skin-surface sanitization mode with safety features for automatically terminating or automatically preventing initiation of a skin sanitization cycle to prevent excessive skin radiation time that could be harmful and preventing radiation that is too intense due to the UV light source being too close to the skin-surface (FIGS. 6-7), and a non-skin surface sanitization mode (FIGS. 6 and 8) which may be unlimited in time duration but in which the UV light source (12) is n ay deenergized if the UV light source (12) is directed at a person's skin is provided in a cellphone configuration (FIGS. 2-5) in which functional elements of a cellphone are also used by the sanitizer functions, a fixed light wand configuration (FIGS. 4-7), flashlight configurations (FIGS. 10-13 and 14-16), a foldable light wand configuration (FIGS. 20-22), a cellphone protector case configuration (FIGS. 26-28) and a cellphone connectable tab configuration (FIGS. 29-31).

Abstract: A steam sterilizer having a door movable relative to an opening between a first open position and a second closed position. A plurality of spaced-apart roller assemblies are aligned along edges of the door to align the door relative to the opening as the door moves between the open and closed position. Each of the roller assemblies are comprised of a cylindrical roller having an outer annual recess extending along the periphery thereof. The recess is dimensioned to receive a lateral edge of the door. The roller is mounted on a shaft and is movable against a biasing force axially along the axis of the shaft.

Abstract: A system and method for sterilizing a wheelchair, stretcher or the like, that comprises an intravenous (IV) pole attaching to the wheelchair or stretcher having an electrical connector at the pole top, and a reflective drape having an interior lined with UV LED lights that electrically connects to the connector on top of the IV pole when draped over the wheelchair or stretcher. The UV LED lights sterilize the wheelchair or other equipment that is under the drape after a period of exposure to UV radiation without using disinfectant chemical sprays or wiping with disinfectant cloths and without staff attention.

Abstract: A system includes a container configured to hold one or more items contaminated with a contaminant. The system also includes a power amplifier configured to output radio frequency (RF) energy at a frequency substantially equal to a resonant frequency of the contaminant. The system further includes a horn connected to the power amplifier and configured to propagate the RF energy along a length of the container and through the one or more items to deactivate, damage, or destroy the contaminant by molecular resonance. In addition, the system includes an RF absorbing liner disposed on interior surfaces of the container and configured to absorb and reduce reflection of at least some of the RF energy.

Abstract: The use of plasma to clean or sterilize items can be particularly advantageous for items that cannot be readily washed or cleaned by standard methods. The toxicity and complications generating sufficient plasma makes it hard to use for such purposes. The subject invention addresses the problem by generating a minimal amount of highly reactive plasma to sterilize an item. This is achieved by reducing the amount of space and ambient air around and within the item. In this way, the plasma generated fills only the required volume of the item to be cleaned and the plasm is directed at the object, not directed at or released into non-target areas.

Abstract: A method for reducing fixation pin track infection rates after the formation of at least one fixation pin track by penetrating skin of patient with a fixation pin as the fixation pin is anchored within an adjacent bone includes applying a composition to a pin site in an area surrounding the fixation pin track, and allowing the composition to form a film covering the pin site.

Abstract: An instrument sterilization monitoring system and an instrument sterilization monitoring method are provided. The instrument sterilization monitoring system includes a server, a sterilization device, and a mobile device. An image capturing module of the mobile device is used to capture image information of a first sterilization device indication device in the sterilization device, image information of a first sterilization device indication label, image information of a second instrument indication device, and image information of a second instrument indication label which are disposed outside an instrument package. The image information is uploaded to the server. The server determines, according to the image information, whether or not the instrument package meets a sterilization standard.

Abstract: There is provided a portable wand system including a wand applicator containing a surface treatment application element. The portable wand system further includes a wand controller subsystem coupled to the wand applicator. The wand controller subsystem includes a computer program, and a depiction of one or more surfaces to be surface treated with the surface treatment application element. The portable wand system further includes a user input button coupled to the wand applicator, an indicator element, a power assembly coupled to the wand controller subsystem, and one or more registration features to register the wand applicator against known location(s) at the one or more surfaces in the depiction. The portable wand system measures positional data of the wand applicator in real-time, and compares the positional data against the depiction, to indicate to a user when a predetermined surface treatment application is achieved for the one or more surfaces.

Abstract: The invention relates to radiopaque liquid embolic composition comprising tetra iodo compound, 4,4-bis (4-hydroxy-3,5 diiodo phenyl) valeric acid (IBHV) of Formula I, covalently linked to ethylene vinyl alcohol copolymer (EVOH) and dissolved in a water miscible organic liquid.

Abstract: The device is intended for the noninvasive induction of dynamic deformation of body tissue to differentiate tissue cells. It comprises the following components: (i) a suspension of particles suspended in solution; and (ii) an external actuator which is capable of magnetically, electrically, vibrationally, or thermally stimulating the suspended particles.

Abstract: A device includes a substrate and a hydrophilic polymer layer made of a hydrophilic polymer having a hydroxyl group. The hydrophilic polymer layer having a hydroxyl group is fixed to at least a part of a surface of the substrate and the hydrophilic polymer further has an amide group. A liquid film retention time of the device is 15 seconds or more. The device has a surface of a substrate which is hydrophilized. A method for producing the device by a simple method is also disclosed.

Abstract: A no-sting skin protectant film forming composition is formulated with a film forming polymer having both polar and nonpolar characteristics, a no-sting nonpolar solvent system, and at least one skin health ingredient. The no-sting skin protectant film forming composition is configured to form a protective film on a skin surface after the solvent system evaporates.

Abstract: A preparation method of drug-loaded micelles of an absorbable vascular stent coating for angiostenosis in an infant is provided, including the following steps: S1: dissolving a drug to be encapsulated in an appropriate amount of an emulsifying agent, adding a chitosan-poly(p-dioxohone) amphiphilic block copolymer (chitosan-b-PPDO copolymer), and thoroughly mixing to obtain a drug-copolymer solution; S2: adding the drug-copolymer solution obtained in S1 dropwise to an emulsifying agent aqueous solution prepared in advance, and continuously stirring to obtain a stable drug-loaded micellar solution; and S3: removing the emulsifying agent from the micellar solution obtained in S2 through vacuum evaporation, stirring a resulting concentrate, and centrifuging the concentrate to obtain a supernatant; and filtering the supernatant to obtain a filtrate, and subjecting the filtrate to dialysis to obtain the drug-loaded micelles.

Abstract: An air-treating apparatus for dispensing a volatilizable material, such as air freshener fragrance, into the atmosphere of an enclosed area. The apparatus includes a housing and a reservoir of the volatilizable material therein, and also includes a multiple-configured air flow path arrangement which enables air-flow through the apparatus in multiple configurations. The apparatus enables use of the consistent delivery rates of a volatilizable material producing a more consistent delivery rate than normally achieved with such devices.

Abstract: A device for the release, in particular for evaporation, of volatile substances such as fragrances or active substances, has a container for a substance to be released. At least one wick as a capillary element is in contact with the substance to be released and at least partially in the receptacle and has a substance release region. The wick, preferably its substance release region, is assigned a heating element, preferably an electrical heating element. The wick is assigned a squeezing device with a squeezing element, by which a squeezing region of the wick can be subjected to a squeezing force and/or can be compressed, in particular for a defined short period of time and/or temporarily. A defined amount of substance, in particular at least the substance collected in the squeezing region, can be conveyed with a boost in the direction of the substance release region.

Abstract: Described herein is a device, and consumer articles associated therewith, for dispensing an active composition and absorbing malodors in the surrounding space.

Abstract: A disinfection device with a pressure vessel which has an interior space for receiving a medium, and with at least one radiating device which is arranged such that it emits radiation into the interior space of the pressure vessel, wherein one or several surfaces of the interior space of the pressure vessel are formed at least partially as a reflection surface for the radiation. A particularly reliable sterilization of medical or dental compressed air in the pressure vessel is made possible. One or several disinfection devices according to the invention can be provided in a compressor system for providing compressed air for dental applications, in a dental treatment device with a compressed air device and/or in a connection device with one or several tube sections for guiding compressed air for dental applications.

Abstract: The present disclosure provides a wearable breast pump, including a host machine, a cup and a flowing channel unit. The host machine includes a variable pressure chamber. The cup is detachably connected to the host machine through the variable pressure chamber. The flowing channel unit is detachably arranged inside the cup and separates an internal space of the cup into a flowing channel and a milk storage bowl. The flowing channel is communicated with the variable pressure chamber, the milk storage bowl and the outside. The wearable breast pump has the flowing channel unit arranged inside the cup, achieving structural optimization, whereby making the structure more concise and the shape more beautiful, as well as increasing the integration level and reducing the occupied space.

Abstract: A water source, an acid source, an electrolyte tank containing a mixture of electrolytes in exactly the quantity needed for the manufacture of the liquid acid concentrate, and a sodium chloride source are connected to a mixing tank. A quantity of water needed for the manufacture of the batch of liquid acid concentrate is introduced into the mixing tank. A quantity of acid needed for manufacture of the liquid acid concentrate is introduced into the mixing tank, the solution is stirred until a homogeneous solution is obtained. Part of the solution contained in the mixing tank is transferred into the electrolyte tank, then the solution contained in the electrolyte tank is transferred into the mixing tank. A quantity of sodium chloride needed to manufacture the liquid acid concentrate is introduced into the mixing tank. The solution is stirred and recirculated until a homogeneous liquid acid concentrate is obtained.

Abstract: A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

Abstract: An oxygenator includes: a housing; a bubble-removing hollow fiber membrane layer removing a bubble; a gas-exchanging hollow fiber membrane layer exchanging a gas with blood; and a discharge port to discharge the bubble removed by the bubble-removing hollow fiber membrane layer to the outside of the housing. The oxygenator further includes a gas permeable portion that is arranged between the discharge port and an end portion of the bubble-removing hollow fiber membrane layer, is formed by a member having gas permeability, and allows passage of the bubble removed by the bubble-removing hollow fiber membrane layer without allowing passage of plasma leaking through the bubble-removing hollow fiber membrane layer. A plasma capture chamber that captures the plasma leaking through the bubble-removing hollow fiber membrane layer is formed between the end portion of the bubble-removing hollow fiber membrane layer and the gas permeable portion.

Abstract: An extracorporeal blood filtering machine can include a blood circuit, an effluent circuit, and a source fluid circuit and can be controlled by a controller. The extracorporeal blood filtering machine can also include access ports for connecting the source fluid circuit to the blood circuit, as well as blood sensors to detect possible issues with the extracorporeal blood filtering machine. The extracorporeal blood filtering machine can include density sensors and flow sensors that enable it to be more accurate and to operate while being transported. The extracorporeal blood filtering machine can further include a user interface and can display fluid inflow/outflow information. A medical fluid container can automatically empty after being filled. An apparatus for supporting a medical fluid container can include a hanger and an attachment member with the apparatus able to adjust to ensure the medical fluid container remains properly oriented directly under a medical fluid container scale.

Abstract: A hemofilter system. In one embodiment, the hemofilter system includes a container having a first surface, a second surface, and one or more wall surfaces, the first surface, the second surface and the one or more wall surfaces defining a volume; an input port in fluid communication with the first surface; an output port in fluid communication with the second surface; a filter bed comprising a plurality of planar magnetic meshes stacked in close juxtaposition and positioned within the container volume and coplanar with the first and second surfaces; a first magnet positioned on a first surface of the container; a second magnet positioned on the second surface of the container; a first input conduit in fluid communication with the input port; and a first output conduit in fluid communication with the output port. In another embodiment, the hemofilter system includes a pump in the input conduit.