Patents Issued in May 28, 2024
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Patent number: 11993536Abstract: An architectural transparency includes a substrate; a first dielectric layer over at least a portion of the substrate, a first metallic layer over the first dielectric layer, a first primer layer over the first metallic layer, a second dielectric layer over the first primer layer, a second metallic layer over the second dielectric layer, a second primer layer over the second metallic layer, a third dielectric layer over the second primer layer, a third metallic layer over the third dielectric layer, a third primer layer over the third dielectric layer, and a fourth dielectric layer over the third primer layer. At least one of the metallic layers is a subcritical metallic layer.Type: GrantFiled: January 21, 2022Date of Patent: May 28, 2024Assignee: Vitro Flat Glass LLCInventors: Adam D. Polcyn, Jeffrey A. Benigni, Abhinav Bhandari, Harry Buhay, James J. Finley, Paul A. Medwick, Dennis J. O'Shaughnessy, Paul R. Ohodnicki, Jr., James P. Thiel, Andrew V. Wagner
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Patent number: 11993537Abstract: The present disclosure describes a substrate loading cassette. The substrate loading cassette includes a first frame, a second frame, a first supporter coupled with the first frame, and a second supporter movably coupled with the first frame and disposed under the first supporter. The first supporter includes a first support bar and a plurality of first branch portions, and the second supporter includes a second support bar and a plurality of second branch portions. The second branch portions move in a second direction to adjust the spacing between the first and second supporters.Type: GrantFiled: September 3, 2021Date of Patent: May 28, 2024Assignee: SAMSUNG DISPLAY CO., LTD.Inventor: Hyo-Seop Kim
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Patent number: 11993538Abstract: A quartz glass provides an opaque quartz glass having high light-shielding property, excellent mechanical strength and excellent cleaning resistance against hydrofluoric acid. By setting the maximum width of the amorphous bubbles existing in the opaque quartz glass to an average of 3 to 15 ?m and the density to 2.15 g/cm3 or more, the mechanical strength after baking and the cleaning resistance by hydrofluoric acid are improved. The opaque quartz glass has a whiteness at a thickness of 10 mm of 75 to 90%, the reflectance of light with a wavelength of 0.24 to 2.6 ?m at a thickness of 4 mm is 60 to 85%, and the bending strength after baking is 95 MPa. In addition, a foaming agent may be mixed in the opaque quartz glass. An opaque quartz glass having cleaning resistance against acid can be obtained.Type: GrantFiled: January 30, 2021Date of Patent: May 28, 2024Assignee: TOSOH QUARTZ CORPORATIONInventors: Takashi Taniguchi, Chiemi Ito, Takaya Suzuki, Yuka Oba
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Patent number: 11993539Abstract: A group of glass compositions in the Li2O—Al2O3—SiO2—B2O3 family that can be chemically strengthened in single or multiple ion exchange baths containing at least one of NaNO3 and KNO3 for a short time (2-4 hours) to develop a deep depth of layer (DOL). In some instances, the DOL is at least 70 ?m; in others, at least about 100 ?m. The ion exchanged glasses have a high damage resistance (indentation fracture toughness ranging form greater than 10 kgf to greater than 50 kgf) that is better than or at least comparable to that of sodium aluminosilicate glasses.Type: GrantFiled: May 10, 2023Date of Patent: May 28, 2024Assignee: CORNING INCORPORATEDInventors: George Halsey Beall, Matthew John Dejneka, Qiang Fu, Sinue Gomez, Robert Michael Morena, Charlene Marie Smith
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Patent number: 11993540Abstract: Waste plastic can be converted into rock for decorative and utilitarian applications. A combination of sand and waste plastic is added into a tumbling chamber, and the tumbling chamber is rotated. The combination of sand and waste plastic is heated while rotating the tumbling chamber to form conglomerates. When a desired size of the conglomerates is achieved, the heating is stopped. Dry cement is then added to the tumbling chamber while continuing to rotate the tumbling chamber.Type: GrantFiled: April 8, 2020Date of Patent: May 28, 2024Inventor: Jonathan Cook
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Patent number: 11993541Abstract: The present invention discloses a multitype-adsorptive-group polycarboxylic acid water-reducing agent, consisting of 30-60 wt % of a macromolecule with multitype-adsorptive groups and water, the macromolecule with multitype-adsorptive groups has a polyethylene glycol side chain, and adsorption groups of the polymer backbone include a carboxylic acid group, a sulfonic acid group and a phosphoric acid group, the phosphoric acid group being linked to the backbone of the macromolecule with multitype-adsorptive groups by nucleophilic addition. The water-reducing agent of the present invention has significantly improved adaptability to different cements and aggregates while maintaining a high water reduction efficiency, compared with the conventional polycarboxylic acid water-reducing agent agent. It has a good water reducing efficiency in many different grades of cement, as well as a better resistance to aggregates containing more impurities such as machine-made sand.Type: GrantFiled: April 18, 2019Date of Patent: May 28, 2024Assignees: SOBUTE NEW MATERIALS CO., LTD., NANJING BOTE NEW MATERIALS CO., LTD.Inventors: Jiaping Liu, Han Yan, Yong Yang, Jinzhi Liu, Xin Shu, Xiumei Wang, Yanwei Wang, Cheng Yu, Qianping Ran
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Patent number: 11993542Abstract: Disclosed are a multifunctional cement hydration heat control material and a manufacturing method therefor. The cement hydration heat control material in is a comb polymer having three side chain structures, the three side chain structures are respectively a carboxyl group, a sugar alcohol group, and a polyether structure, and the main chain of the polymer is a carbon chain structure formed by free-radical polymerization of a double bond in a double bond compound monomer. The multifunctional cement hydration heat control material can achieve integration of cement hydration heat control performance, water reduction performance, and shrinkage reduction performance in a same molecule, can achieve control focusing on a performance by means of structural adjustment, does not need multi-component compounding during use, and is more convenient. The control material is non-toxic and water-soluble, can be made to have an appropriate concentration, and is convenient to use.Type: GrantFiled: November 14, 2019Date of Patent: May 28, 2024Assignees: SOBUTE NEW MATERIALS CO., LTD., BOTE NEW MATERIALS TAIZHOU CO., LTD., ZHENJIANG SOBUTE NEW MATERIAL CO., LTD.Inventors: Jiaping Liu, Rui Wang, Qian Tian, Wenbin Wang, Lei Li, Yujiang Wang, Hua Li, Ting Yao, Yang Chu
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Patent number: 11993543Abstract: A method of producing green concrete, and particularly to green concrete with Portland cement (C), natural basaltic volcanic ash pozzolan (VA), and microsilica (MS). The green concrete described herein is a high-performance green concrete composition that partially substitutes Portland Cement (C) and can further include fine aggregates (FA) and coarse aggregates (CA), water (W), and a super plasticizer (SP). The green concrete described herein can be cured at ambient temperature and can have a better compressive strength and durability properties, and high shrinkage resistance as compared to conventional concrete and, as such, can be used for high performance applications.Type: GrantFiled: December 28, 2023Date of Patent: May 28, 2024Assignee: KING FAISAL UNIVERSITYInventors: Kaffayatullah Khan, Muhammad Nasir Amin, Muhammad Tayyab Naqash
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Patent number: 11993544Abstract: A green concrete composition comprising: a binder component comprising Portland cement (C), volcanic ash (VA), metakaolin (MK), and colloidal nano-silica (CNS); an aggregate component comprising fine aggregates (FA) and coarse aggregates (CA); water (W); and a super plasticizer.Type: GrantFiled: December 8, 2023Date of Patent: May 28, 2024Assignee: KING FAISAL UNIVERSITYInventors: Kaffayatullah Khan, Muhammad Nasir Amin, Megat Azmi Megat Johari
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Patent number: 11993545Abstract: A silicon carbide ceramic honeycomb structure having large numbers of axially penetrating flow paths partitioned by porous silicon carbide cell walls, the cell walls having porosity of 35-50% and a median pore diameter of 8-18 ?m, when a straight line C is drawn in parallel with the cell wall surface such that it passes a center in the direction of the thickness T of the cell wall, and straight lines are drawn in parallel with the straight line C such that they are separate from the straight line C by ±T/5 and ±2T/5 in the thickness direction of the cell wall, to measure the lengths (pore widths) of pore portions crossing each straight line, and the number of pores crossing each straight line, in a cell wall cross section perpendicular to the axial direction, an average pore width W determined by averaging the lengths (pore widths) of all measured pore portions being 10-25 ?m, and the number N of pores per length determined by dividing the total number of the measured pores by the total length of the straightType: GrantFiled: March 23, 2022Date of Patent: May 28, 2024Assignee: PROTERIAL, LTD.Inventor: Kenichiro Shimizu
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Patent number: 11993546Abstract: Methods and ceramic matrix composite articles formed thereby, as well as systems for making such ceramic matrix composite articles and carrying out such methods are disclosed herein. The methods include preparing a ceramic matrix composite by steps including (a) providing reinforcing fiber, such as carbon fiber, for impregnation; (b) heat treating the reinforcing fiber; (c) impregnating the heat treated reinforcing fiber with a composition comprising a ceramic forming polymer to form a fiber reinforced, ceramic forming polymer pre-preg; and (d) heat molding the fiber reinforced, ceramic forming polymer pre-preg to form a molded ceramic matrix composite article.Type: GrantFiled: August 23, 2021Date of Patent: May 28, 2024Assignee: Lancer Systems LPInventors: Kenneth Church, Timothy J. Edwards, Terry A. Herb, Christopher Corrado
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Patent number: 11993547Abstract: An electrical termination unit or feedthrough which may be used for routing electrical conductors through a chamber wall, or otherwise across a barrier between isolated atmospheric conditions. The electrical termination unit may have aluminum as the interface material to the chamber interface and may utilize a ceramic insulator. The electrical termination unit may have the aluminum used as the interface brazed directly to a ceramic surface of the insulator. The aluminum that forms the chamber interface may be formed within a hollow ceramic tube in the same process step that brazes the aluminum to the ceramic tube with a hermetic joint. Machining subsequent to the brazing of the aluminum to the ceramic insulator may allow for achievement of the final form desired. A method for manufacturing such an electrical termination unit.Type: GrantFiled: June 8, 2021Date of Patent: May 28, 2024Assignee: Watlow Electric Manufacturing CompanyInventors: Brent Elliot, Dennis George Rex, Guleid Hussen, Michael Parker, Jason Stephens
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Patent number: 11993548Abstract: A tooling assembly suitable for use in infiltrating a fibrous preform comprises an outer tooling fixture with a plurality of outer sidewalls defining an inner volume, each of the plurality of outer sidewalls having an outer wall thickness, and a window extending through the outer wall thickness of at least one outer sidewall of the plurality of sidewalls. The tooling assembly further comprises an inner tooling fixture positioned within the inner volume of the outer tooling fixture, the inner tooling having a plurality of inner sidewalls, each of the plurality of inner sidewalls having an inner wall thickness, and a plurality of holes extending through the inner wall thickness of at least one inner sidewall of the plurality of inner sidewalls. The at least one outer sidewall is positioned adjacent the at least one inner sidewall such that the window overlaps with at least a subset of the plurality of holes in the at least one inner sidewall.Type: GrantFiled: September 30, 2022Date of Patent: May 28, 2024Assignee: RTX CorporationInventors: Alyson T. Burdette, Jon Erik Sobanski, Kenneth Petroski, Ying She, Kathryn S. Read
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Patent number: 11993549Abstract: A solids separator for use in a composting system for separating solid waste from liquid waste in a stream of waste includes a housing defining a waste inlet for receiving the stream of waste, a liquids outlet for passing the liquid waste, and a solids outlet for passing the solid waste. A separator belt is positioned within the housing and extending between the liquids outlet and the solids outlet, the separator belt defining a plurality of apertures through which the liquid waste passes through the separator belt and into the liquids outlet. A drive cylinder is rotatably mounted within the housing for selectively rotating the separator belt such that a top surface of the belt is moved toward the solids outlet along with the solid waste that is extracted from the stream of waste.Type: GrantFiled: November 24, 2020Date of Patent: May 28, 2024Assignee: Haier US Appliance Solutions, Inc.Inventor: Wilbur Carl Bewley, Jr.
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Patent number: 11993550Abstract: The present invention provides for the use of at least one oil soluble polymer comprising linear polymethylene sequences with an average of 10 to 40 consecutive methylene groups to improve the water resistance of an explosive composition comprising particulate ammonium nitrate and a fuel oil, said linear polymethylene sequences with in average 10 to 40 consecutive methylene groups may be either in the main chain or in the side chains of the oil soluble polymer.Type: GrantFiled: March 13, 2017Date of Patent: May 28, 2024Assignee: CLARIANT INTERNATIONAL LTDInventors: Michael Feustel, Matthias Krull, Ian James Tolliday, Christopher Robin Collins, Maja Franjic, Thomas Roy
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Patent number: 11993551Abstract: A process (100) for the production of linear alpha-olefins is proposed, wherein ethylene in a feed mixture is subjected to catalytic oligomerization (1) to obtain a product mixture containing alpha-olefins with different chain length and side compounds. In a primary fractionation (2), a primary fraction is formed using at least part of the product mixture, and in a secondary fractionation (4), a secondary fraction is formed using at least part of the primary fraction. The primary fractionation (2) and the secondary fractionation (4) are carried out such that the primary fraction and the secondary fraction predominantly contain one of the alpha-olefins and are low in or free of other alpha-olefins, that the primary fraction contains one or more of the side compounds, and that the secondary fraction is depleted relative to the primary fraction in the one or more side compounds.Type: GrantFiled: January 28, 2020Date of Patent: May 28, 2024Assignee: LINDE GmbHInventors: Florian Winkler, Richard Schneider, Florian Mündl
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Patent number: 11993552Abstract: The present disclosure discloses a method and a device for continuously synthesizing cyclopropane compounds. The method includes the following steps: continuously performing a synthetic reaction of a diazomethane precursor in a first reactor, the reaction product of the first reactor flowing into a separator for stratification, the organic phase obtained by stratification overflowing into a second reactor, continuously consuming the diazomethane precursor in a second reactor to prepare diazomethane and performing an electron-rich monoolefin cyclopropanation reaction in situ so as to obtain the cyclopropane compound.Type: GrantFiled: July 2, 2019Date of Patent: May 28, 2024Assignee: ASYMCHEM LABORATORIES (TIANJIN) CO., LTD.Inventors: Hao Hong, Jiangping Lu, Xichun Feng, Xingfang Sun, Feng Zhang
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Patent number: 11993553Abstract: Compositions that include cationic surfactants and methods of synthesizing compositions that include cationic surfactants. The surfactants include a quaternary amine and a saturated or unsaturated alkyl chain with 4 to 28 carbons. The surfactants can be generated by reacting a fatty acid modified with an amino alkyl group and an epihalohydrin in the presence of a base. The cationic surfactants can be generated by reacting a fatty acid modified with an amino alkyl group, an epihalohydrin, and a carboxylic acid. The cationic surfactants can be generated by reacting a carboxylic acid, an epihalohydrin, and a catalyst to afford a halo-substituted alkyl ester, followed by reacting the halo-substituted alky ester with a fatty acid modified with an amino alkyl group.Type: GrantFiled: December 15, 2021Date of Patent: May 28, 2024Assignee: Saudi Arabian Oil CompanyInventors: Xuan Zhang, Ming Han, Jinxun Wang
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Patent number: 11993554Abstract: A compound 3,3?-(hydrazine-1,2-diyl)bis(1-(naphthalen-2-yloxy)propan-2-ol), its synthesis, and its use as an insecticidal agent.Type: GrantFiled: November 16, 2023Date of Patent: May 28, 2024Assignee: KING FAISAL UNIVERSITYInventors: Mai Mostafa Khalaf Ali, Hany Mohamed Abd El-Lateef Ahmed, Antar Ahmed Abdelhamid Ahmed, Mohamed A. Gad
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Patent number: 11993555Abstract: Disclosed are a type of conjugated triene compounds (1), and a preparation and application thereof. In this method, a 2-(cyclohexenylidene)malonic acid derivative is sequentially subjected to isomerization, halogenation reaction in the presence of a halogenating agent and dehydrohalogenation to prepare the conjugated triene compounds (1). This disclosure further provides a method of preparing a 2-aryl malonic acid derivative from the conjugated triene compounds (1) through aromatization reaction.Type: GrantFiled: September 29, 2021Date of Patent: May 28, 2024Assignee: ORIENTAL(LUZHOU) AGROCHEMICALS CO., LTD.Inventors: Bangchi Chen, Yinwei Sun, Zhongyuan Wang, Teng Lai
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Patent number: 11993556Abstract: Novel peptoid compounds, compositions and methods of using the compounds and compositions to inhibit protein arginine methyltransferase (PRMT) and induce apoptosis in cancer cells are presented.Type: GrantFiled: November 16, 2021Date of Patent: May 28, 2024Assignee: University of North Florida Board of TrusteesInventors: Bryan Knuckley, Corey P. Causey, Fatima Khwaja Rehman
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Patent number: 11993557Abstract: A method for the production of a urea ammonium sulphate (UAS) composition in a pipe reactor comprising at least a reactor section, the method comprising: combining in the reactor continuous feeds of at least one of sulphuric acid and ammonium bisulphate, at least one of ammonia and ammonium carbamate, and urea; and including a viscosity-reducing agent selected from water soluble aluminum salts in at least one of the continuous feeds, thereby forming the urea ammonium sulphate (UAS composition, wherein the UAS composition comprises 1 to 40 weight % of ammonium sulphate (AS) relative to the total weight of the UAS composition.Type: GrantFiled: March 20, 2019Date of Patent: May 28, 2024Assignee: YARA INTERNATIONAL ASAInventors: Ruud Van Belzen, Howard Volke, Erika Winne
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Patent number: 11993558Abstract: The present invention relates to a process for producing alcohols by hydrogenation of C9 aldehydes. The process according to the invention is performed in two consecutive hydrogenation stages, wherein the first hydrogenation stage employs an activated metal catalyst based on a nickel metal foam and the second stage employs a supported catalyst containing a catalytically active component from the group consisting of nickel, copper, chromium and mixtures thereof.Type: GrantFiled: February 24, 2023Date of Patent: May 28, 2024Assignee: EVONIK OPERATIONS GMBHInventors: Robert Franke, Meike Roos, Horst-Werner Zanthoff, Julia Bauer, Christoph Weber, Andrea Heinroth, Jan Benedikt Metternich
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Patent number: 11993559Abstract: The invention relates to a process for treating an alcoholic feedstock, comprising: a) a stage of preheating of said alcoholic feedstock to a temperature of between 70° C. and 200° C.; b) a stage of pretreatment on an acidic solid, operating at a temperature of between 70° C. and 200° C., to produce a pretreated alcoholic feedstock; c) a stage of partial vaporization to produce a vaporized stream and a liquid stream; and d) a stage of purification of the liquid stream resulting from stage c), to give a stream rich in water, a stream rich in monoalcohol and a stream rich in impurities.Type: GrantFiled: November 27, 2019Date of Patent: May 28, 2024Assignees: TOTAL RESEARCH & TECHNOLOGY FELUY, IFP Energies NouveliesInventors: Nicolas Aribert, Ludovic Chahen, Arnaud Lanoue, Vincent Coupard, Nikolai Nesterenko
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Patent number: 11993560Abstract: A method of and apparatus for recovering an alcohol solvent from a liquid mixture of the solvent and plant oil and decarboxylating the plant oil may include, pressurizing the liquid mixture to a super-atmospheric pressure, recirculating the pressurized liquid mixture a plurality of times through at least one membrane separator to separate some of the solvent from the mixture to provide a concentrated mixture of the plant oil with less solvent, reducing the pressure of the liquid concentrated mixture to less than 15 psig, heating it at a pressure of less than 15 psig to a temperature sufficient to vaporize the solvent in the concentrated mixture, removing sufficient heat from the vaporized solvent to condense it to a liquid solvent at atmospheric pressure and temperature conditions, and heating the plant oil to a temperature desirably of at least 215° F. to decarboxylate the plant oil.Type: GrantFiled: April 28, 2021Date of Patent: May 28, 2024Assignee: MACH TechnologiesInventors: Robert N. Wirtz, Jason T. Wirtz, John W. Wirtz, II
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Patent number: 11993561Abstract: The present disclosure discloses an expectorant compound, and specifically discloses compounds represented by formula I and formula II, pharmaceutically acceptable salts or tautomers thereof.Type: GrantFiled: July 1, 2020Date of Patent: May 28, 2024Assignee: HC SYNTHETIC PHARMACEUTICAL CO., LTD.Inventors: Cheng Yang, Sumin Qi, Qiyuan Zhang, Dongxing Li, Tieshan Chen, Xiaodan Zhao
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Patent number: 11993562Abstract: The invention provides a plurality of methods which may be employed as a single method or a plurality of sequential method steps in the isolation and purification of Cannabidiol from Hemp plants. It also provides methods for having a terpene-rich fraction as a byproduct of the method. Depending upon the ultimate objective, the individual method components may be used separately or combined with one or more method steps to accomplish the objectives.Type: GrantFiled: March 31, 2022Date of Patent: May 28, 2024Assignee: RJ LEE GROUP, INC.Inventors: Alan M. Levine, Steven J. Monaco, Richard J. Lee, Duane M. Erickson
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Patent number: 11993563Abstract: The present invention relates to solid compositions comprising cocrystals of cannabinoids, processes for their preparation, and their use as in therapy or in cosmetics or for the purification of cannabinoids. It also relates to cocrystals of cannabinoids.Type: GrantFiled: October 31, 2019Date of Patent: May 28, 2024Assignee: ENANTIA S.L.Inventors: Nicolas Tesson, Montserrat Trilla Castaño, Alexander Christian Comely
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Patent number: 11993564Abstract: Provided is a method of decomposing phenolic by-products, and more particularly, a method of decomposing phenolic by-products including: supplying a phenolic by-product stream to a decomposition device to perform thermal decomposition; separating an upper discharge stream including effective components and a lower discharge stream including materials having a high boiling point in the decomposition device; supplying the lower discharge stream from the decomposition device, a side discharge stream from the decomposition device, and a process water stream to a mixing device and mixing these streams; and supplying a discharge stream from the mixing device to a layer separation device to separate the discharge stream from the mixing device into an oil phase and an aqueous phase.Type: GrantFiled: June 15, 2021Date of Patent: May 28, 2024Assignee: LG Chem, Ltd.Inventors: Min Suk Kang, Sang Beom Lee, Ji Hyang Son, Chi Hyun Jang
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Patent number: 11993565Abstract: A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.Type: GrantFiled: December 16, 2021Date of Patent: May 28, 2024Assignee: SCION Holdings LLCInventors: Kyle Killebrew, Samuel Livingston Lane
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Patent number: 11993566Abstract: A hydroformylation method including preparing an aldehyde by reacting a raw-C5 feed with a synthetic gas in the presence of a catalyst composition.Type: GrantFiled: July 26, 2021Date of Patent: May 28, 2024Assignee: LG Chem, Ltd.Inventors: Yonghyun Kwon, Hyunseok Nam, Jihoon Kim, Jangkeun Cho, Daeheung Choi
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Patent number: 11993567Abstract: A method for preparing an aldehyde including forming a reaction product including an aldehyde by reacting an olefin-based compound with a synthetic gas in a hydroformylation reactor in the presence of a hydroformylation catalyst; introducing the reaction product including the aldehyde to a vaporizer; separating low-boiling point components of the reaction product from an upper part of a vaporizer catch pot included in the vaporizer; separating high-boiling point components of the reaction product from a lower part of the vaporizer catch pot; and recirculating at least a portion of the low-boiling point components separated from an upper part of the vaporizer catch pot back to the vaporizer.Type: GrantFiled: August 26, 2021Date of Patent: May 28, 2024Assignee: LG Chem, Ltd.Inventors: Jusang Yang, Sangjun Shin, Sungshik Eom, Tae Yun Kim, Dong Hyun Ko, Sungpil Yang
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Patent number: 11993568Abstract: Multi-reactor systems with aromatization reactor vessels containing a catalyst with low surface area and pore volume, followed in series by aromatization reactor vessels containing a catalyst with high surface area and pore volume, are disclosed. Related reforming methods using the different aromatization catalysts also are described.Type: GrantFiled: April 15, 2020Date of Patent: May 28, 2024Assignee: Chevron Phillips Chemical Company LPInventors: Ryan W. Snell, Gabriela D. Alvez-Manoli, Xianghong Hao
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Patent number: 11993569Abstract: Disclosed are cyclopentene compounds for use as inhibitors of aminotransferases such as gamma-aminobutyric acid (GABA) aminotransferase (AT) and/or ornithine aminotransferase (OAT). The disclosed cyclopentene compounds include 3-amino-4-halocyclopente carboxylic acid compounds which may be formulated in pharmaceutical composition for treating diseases and disorders associated with GABA-AT and/or OAT activity, including epilepsy, addiction, hepatocellular carcinoma (HCC), and non-small cell lung cancer (NSCLC).Type: GrantFiled: January 22, 2021Date of Patent: May 28, 2024Assignee: Northwestern UniversityInventors: Richard B. Silverman, Sida Shen
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Patent number: 11993570Abstract: The present invention provides a technique that enables introduction of active ingredients, in particular, nucleic acids, into cells with superior efficiency; and cationic lipids, etc., for use in the technique. The compound or a salt thereof according to the present invention is a compound represented by formula (I) or a salt thereof. In formula (I), n represents an integer of 2 to 5, R represents a linear C1-5 alkyl group, a linear C7-11 alkenyl group, or a linear C11 alkadienyl group, and wavy lines each independently represent a cis-bond or a trans-bond.Type: GrantFiled: August 31, 2022Date of Patent: May 28, 2024Assignee: TAKEDA PHARMACEUTICAL COMPANY LIMITEDInventors: Satoru Matsumoto, Yoshimasa Omori, Masahiro Mineno, Yasutaka Hoashi
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Patent number: 11993571Abstract: Disclosed herein are compounds of formula (I): and salts thereof. Also disclosed are compositions comprising compounds of formula I and compounds of formula I for use in treating or preventing bacterial infections.Type: GrantFiled: March 9, 2018Date of Patent: May 28, 2024Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEYInventors: Edmond J. LaVoie, Ajit Parhi, Yi Yuan, Yongzheng Zhang, Yangsheng Sun
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Patent number: 11993572Abstract: The present invention relates to a composition which comprises an electron-transporting host and a hole-transporting host, to the use thereof in electronic devices and to electronic devices containing this composition. The electron-transporting host is particularly preferably selected from the class of the lactams. The hole-transporting host is preferably selected from the class of the biscarbazoles.Type: GrantFiled: July 2, 2018Date of Patent: May 28, 2024Assignee: Merck Patent GmbHInventors: Amir Parham, Jonas Kroeber, Tobias Grossmann, Anja Jatsch, Christian Eickhoff, Christian Ehrenreich
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Patent number: 11993573Abstract: Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.Type: GrantFiled: February 4, 2021Date of Patent: May 28, 2024Assignee: THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITYInventors: Kenneth Darrell Berlin, Richard A. Bunce, Krishna Kumar Gnanasekaran, Field M. Watts, Jr., Donghua Howard Zhou
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Patent number: 11993574Abstract: Disclosed herein are compounds of the formula: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to modulate the activity of IL-17 and ROR?. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or for autoimmune disorders.Type: GrantFiled: June 17, 2019Date of Patent: May 28, 2024Assignee: REATA PHARMACEUTICALS, INCInventors: Xin Jiang, Melean Visnick, Christopher F. Bender, Gary Bolton, Bradley Caprathe, Chitase Lee, Brian Kornberg, Patrick O'Brien, Martha R. Hotema
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Patent number: 11993575Abstract: A ethyl [4,4-bis(4-bromophenyl)-2,5-dioxoimidazolidin-1-yl]acetate compound, its synthesis, and its use as an antimicrobial agent.Type: GrantFiled: December 29, 2023Date of Patent: May 28, 2024Assignee: KING FAISAL UNIVERSITYInventors: Mai Mostafa Khalaf Ali, Hany Mohamed Abd El-Lateef Ahmed, Mohamed Gouda, Antar Ahmed Abdelhamid Ahmed
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Patent number: 11993576Abstract: The invention provides an N-benzyl-N-arylsulfonamide derivative, which is an N-benzyl-N-arylsulfonamide compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof. The N-benzyl-N-arylsulfonamide derivative is obtained by condensing a substituted nitrobenzene with 5- or 6-membered nitrogen-containing aliphatic heterocycle (the ring B), reducing the nitro group to an amino group, and subjecting the amino group to reductive amination, sulfonamidation; or by subjecting a substituted nitrobenzene to nitro reduction, reductive amination and sulfonamidation, and condensing the resultant intermediate with 5- or 6-membered nitrogen-containing aliphatic heterocycle (the ring B). It has been experimentally demonstrated that the N-benzyl-N-arylsulfonamide derivative of the invention can specifically bind to Kv1.3 potassium channel and inhibit or decrease its activity, and is useful in the treatment of autoimmune diseases caused by abnormal activation of the Kv1.Type: GrantFiled: January 21, 2020Date of Patent: May 28, 2024Assignee: HANGZHOU YIRUI PHARMACEUTICAL TECHNOLOGY CO., LTDInventors: Xiaolu Wang, Yongzhou Hu, Qing Ye, Xiuai Hu
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Patent number: 11993577Abstract: Provided herein is a process for the preparation of 3,4-methylenedioxymethamphetamine, (R)-3,4-methylenedioxymethamphetamine and (S)-3,4-methylenedioxymethamphetamine.Type: GrantFiled: September 1, 2022Date of Patent: May 28, 2024Assignee: EmpathBio, Inc.Inventors: Majed Fawaz, Nicholas Morra
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Patent number: 11993578Abstract: Embodiments provide a harmful organism control agent containing a pyrazole-3-carboxylic acid amide derivative or a salt thereof as an active ingredient, having an excellent harmful organism controlling effect. A pyrazole-3-carboxylic acid amide derivative represented by general formula [I]: (wherein, R1, R2, R3, R4, and R5 represent a hydrogen atom, halogen atom, C1-C6 alkyl group or the like, R6 represents a C1-C12 alkyl group, C1-C12 haloalkyl group or the like, R7 and R8 represent a hydrogen atom, C1-C12 alkyl group or the like) or an agriculturally acceptable salt thereof, and a harmful organism control agent containing the pyrazole-3-carboxylic acid amide derivative or an agriculturally acceptable salt thereof as an active ingredient.Type: GrantFiled: May 9, 2018Date of Patent: May 28, 2024Assignee: KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Akira Kinpara, Ryo Ishikawa, Keiji Toriyabe, Katsuya Kato, Masao Nakatani, Akira Takanezawa, Takeshi Matsuda
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Patent number: 11993579Abstract: A 3-(1-(3-(dimethylamino)propyl)-4,5-diphenyl-1H-imidazol-2-yl)pyridin-4-ol compound, its synthesis, and its use as an anti-microbial agent.Type: GrantFiled: September 13, 2023Date of Patent: May 28, 2024Assignee: KING FAISAL UNIVERSITYInventors: Mai Mostafa Khalaf Ali, Hany Mohamed Abd El-Lateef Ahmed, Antar Ahmed Abdelhamid Ahmed, Adel A. Marzouk
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Patent number: 11993580Abstract: The present disclosure relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein the variable are as described herein, and compositions and uses of same for treating neurological disorders.Type: GrantFiled: December 1, 2023Date of Patent: May 28, 2024Assignee: Neumora Therapeutics, Inc.Inventors: Paul Dransfield, Dilinie Fernando, James Harvey, Brian Sparling, John Stellwagen, Zhihua Ma, Anne-Marie Beausoleil, Ryan Hudson
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Patent number: 11993581Abstract: Pyridazine compounds for inhibiting NaV1.8 and methods for treating a condition, disease, or disorder associated with an increased NaV1.8 activity or expression are disclosed.Type: GrantFiled: July 9, 2019Date of Patent: May 28, 2024Assignee: LIEBER INSTITUE, INCInventors: Michael Poslusney, Glen Ernst, James Barrow
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Patent number: 11993582Abstract: This application relates to various crystalline forms of (S)-3-amino-4-(5-(4-((5-chloro-3-fluoropyridin-2-yl)oxy)phenyl)-2H-tetrazol-2-yl)butanoic acid in its free form, as well as compositions, method of making and methods of using the same. In some embodiments the crystalline forms also contain water (“hydrates”). These materials are useful in the treatment of diseases and disorders which are typically ameliorated by the inhibition of LTA4H. Such diseases and disorders may include inflammatory and autoimmune disorders and pulmonary and respiratory tract inflammation.Type: GrantFiled: July 29, 2019Date of Patent: May 28, 2024Assignee: Novartis AGInventors: Andreas Kordikowski, Yanxiang Wu
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Patent number: 11993583Abstract: The present disclosure relates to a compound of formula (Ia), (Ib), (IIa), and (IIb): which are useful in the treatment of a Retroviridae viral infection including an infection caused by the HIV virus.Type: GrantFiled: November 25, 2019Date of Patent: May 28, 2024Assignee: Gilead Sciences, Inc.Inventors: Michael Graupe, John O. Link, Roland D. Saito, Scott D. Schroeder, Dimitrios Stefanidis, Winston C. Tse, Jennifer R. Zhang
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Patent number: 11993584Abstract: The present invention provides solid forms, solvates and hydrates of 3-[2-amino-6-(1-{[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl}-1H-1,2,3-triazol-4-yl)pyrimidin-4-yl]-2-methylbenzonitrile (Compound I), and methods of making and using the same.Type: GrantFiled: July 17, 2019Date of Patent: May 28, 2024Assignee: ARCUS BIOSCIENCES, INC.Inventors: Jenna Leigh Jeffrey, Manmohan Reddy Leleti, Dillon Harding Miles, Jay Patrick Powers
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Patent number: 11993585Abstract: The present invention is related to a pharmaceutical composition comprising a pharmaceutically acceptable carrier or diluent and a compound represented by the following structural formula: The present invention is also related a method of treating a subject with a disease which can be ameliorated by inhibition of poly(ADP-ribose)polymerase (PARP). The definitions of the variables are provided herein.Type: GrantFiled: June 9, 2021Date of Patent: May 28, 2024Assignee: Mitobridge, Inc.Inventors: Taisuke Takahashi, Arthur Kluge, Bharat Lagu, Nan Ji