Patents Issued in June 18, 2024
-
Patent number: 12012547Abstract: The present disclosure is directed to surfactants (in particular olefin sulfonates), surfactant packages, compositions derived thereof, and uses thereof in hydrocarbon recovery. Methods of making olefin sulfonate surfactants are also described.Type: GrantFiled: October 30, 2020Date of Patent: June 18, 2024Assignees: CHEVRON U.S.A. INC., CHEVRON ORONITE COMPANY LLCInventors: Gayani W. Pinnawala, Varadarajan Dwarakanath, Andrew M. Thomas, Curtis B. Campbell, Andrew M. Davidson, Ping Wang
-
Patent number: 12012548Abstract: The present invention provides environmentally-friendly compositions and methods for recovering oil from oil sands. The present invention can also be used for reducing the viscosity and/or increasing the API gravity of oil. In specific embodiments, the invention utilizes compositions comprising biochemical-producing microorganisms and microbial growth by-products, such as biosurfactants, as well as cavitation, to enhance oil recovery.Type: GrantFiled: July 8, 2022Date of Patent: June 18, 2024Assignee: LOCUS SOLUTIONS IPCO, LLCInventors: Sean Farmer, Ken Alibek, Karthik N. Karathur
-
Patent number: 12012549Abstract: The present disclosure is directed to surfactants (in particular olefin sulfonates), surfactant packages, compositions derived thereof, and uses thereof in hydrocarbon recovery. Methods of making olefin sulfonate surfactants are also described.Type: GrantFiled: October 30, 2020Date of Patent: June 18, 2024Assignees: CHEVRON USA INC, CHEVRON ORONITE COMPANY LLCInventors: Varadarajan Dwarakanath, Gayani W. Pinnawala, Andrew M. Thomas, Curtis B. Campbell, Andrew M. Davidson, Ping Wang
-
Patent number: 12012550Abstract: A method for acid treating a carbonate reservoir with an attenuated acid formulation is provided. The method includes mixing an acidic compound with a hygroscopic chemical to form the attenuated acid formulation, and injecting the attenuated acid formulation into a carbonate formation.Type: GrantFiled: December 13, 2021Date of Patent: June 18, 2024Assignee: Saudi Arabian Oil CompanyInventors: Mohammed Sayed, Rajesh Kumar Saini
-
Patent number: 12012551Abstract: The present disclosure provides for UV-responsive laminates including a first layer having a photochromatic pigment arranged as a pigment texture, or one or more photochromatic indicators, or combinations thereof. The photochromatic pigment may be disposed on the laminate during laminate fabrication, prior to installation of the laminate, or in-situ, subsequent to installation. The photochromatic pigment is configured to change from a first state to a second state in response to exposure to an ultraviolet (UV) light source, the first state is invisible to a naked eye under ambient lighting and the second state is visible to the naked eye under ambient lighting. The UV-responsive laminates may further include additional layers, such as a second layer which may be a coupling layer configured to removably couple the laminate to a component. Additional layers, such as a protective layer or a backing layer, may be included in the UV-responsive laminate as well.Type: GrantFiled: September 24, 2021Date of Patent: June 18, 2024Assignee: THE BOEING COMPANYInventor: Darren C. McIntosh
-
Patent number: 12012552Abstract: A combined hydrothermal liquefaction (HTL) and catalytic hydrothermal gasification (CHG) system and process are described that convert various biomass-containing sources into separable bio-oils and aqueous effluents that contain residual organics. Bio-oils may be converted to useful bio-based fuels and other chemical feedstocks. Residual organics in HTL aqueous effluents may be gasified and converted into medium-BTU product gases and directly used for process heating or to provide energy.Type: GrantFiled: July 27, 2022Date of Patent: June 18, 2024Assignee: Battelle Memorial InstituteInventors: Douglas C. Elliott, Gary G. Neuenschwander, Todd R. Hart
-
Patent number: 12012553Abstract: A plastic pyrolysis process produces light olefin product and heavier products. The light olefin products are separated in a recovery process while the heavier product can be sent to a cracking unit to be further cracked to desired products. The cracked effluent stream may be subjected to the recovery process along with the light olefin product.Type: GrantFiled: June 28, 2021Date of Patent: June 18, 2024Assignee: UOP LLCInventors: Michael S. Allegro, II, Andrea Bozzano, Joseph A. Montalbano
-
Patent number: 12012554Abstract: A process for converting crude oil to light olefins, aromatics, or both, includes contacting a crude oil with an FCC catalyst composition in a catalytic cracking system at a temperature of greater than or equal to 580° C., a weight ratio of the FCC catalyst to the crude oil of from 2:1 to 10:1, and a residence time of from 0.1 seconds to 60 seconds. Contacting causes at least a portion of hydrocarbons in the crude oil to undergo cracking reactions to produce a cracked effluent comprising at least olefins. The FCC catalyst composition for producing olefins and aromatics from crude oil includes ultrastable Y-type zeolite impregnated with lanthanum, ZSM-5 zeolite impregnated with phosphorous, an alumina binder, colloidal silica, and a matrix material comprising Kaolin clay.Type: GrantFiled: July 6, 2022Date of Patent: June 18, 2024Assignee: Saudi Arabian Oil CompanyInventors: Mansour Ali Al-Herz, Musaed Salem Al-Ghrami, Qi Xu, Aaron Akah
-
Patent number: 12012555Abstract: Systems and methods for producing light olefins wherein a feed stream comprising naphtha is flowed into a reaction unit comprising a fast fluidized bed reactor coupled to and in fluid communication with a riser reactor. The fast fluidized bed reactor comprises baffles therein to minimize backmixing therein to maximize the production of light olefins. The effluent from the fast fluidized bed reactor is further flowed to the riser reactor. The lift gas, which can comprise nitrogen, methane, flue gas, or combinations thereof, is injected in the reaction united via a sparger. Effluent of the riser reactor is separated in a product separation unit to produce a product stream comprising light olefins and spent catalyst. Spent catalyst is further stripped by a stripping gas comprising methane, nitrogen, flue gas, or combinations thereof. Stripped spent catalyst is regenerated to produce regenerated catalyst, which is subsequently flowed to the fast fluidized bed reactor.Type: GrantFiled: July 30, 2020Date of Patent: June 18, 2024Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventor: Mayank Kashyap
-
Patent number: 12012556Abstract: Systems and methods for producing light olefins via catalytic cracking of naphtha are disclosed. A naphtha feed stream and lift gas stream are fed into a dense phase riser reactor operated with a high solid volume fraction, a high superficial velocity, minimum back mixing. The effluent stream from the dense phase riser reactor is further separated, in a secondary reactor, to form a gaseous product stream and a catalyst stream. The catalyst stream is stripped to remove the hydrocarbons adsorbed on the catalyst particles. The stripped catalyst is regenerated in a regenerator.Type: GrantFiled: July 21, 2020Date of Patent: June 18, 2024Assignee: SABIC GLOBAL TECHNOLOGIES B.V.Inventor: Mayank Kashyap
-
Patent number: 12012557Abstract: A start-up method for contacting a feed stream with fluidized catalyst is disclosed. The start-up method comprises reacting a feed stream over a catalyst to produce a gas stream and spent catalyst. The gas stream is separated from the spent catalyst. The separated gas stream is passed to a compressor. The operating condition associated with the compressor is measured. Based on the measured operating condition associated with the compressor, one or both of a supplemental hydrocarbon stream and a supplemental hydrogen gas stream is provided to the compressor to meet a predetermined operating condition associated with the compressor.Type: GrantFiled: October 20, 2022Date of Patent: June 18, 2024Assignee: UOP LLCInventors: Steven C. Kozup, Michael R. Van de Cotte, Adam J Kanyuh
-
Patent number: 12012558Abstract: The present disclosure is directed to systems and methods for reforming a hydrocarbon fuel to increase the cetane value of the hydrocarbon fuel. The system includes a microstatic mixer and a microchannel reactor downstream of the microstatic mixer. The microchannel reactor includes a microchannel with an NHPI catalyst coated onto the walls of the microchannel. A hydrocarbon fuel and an oxygen-containing gas are combined and mixed in the microstatic mixer to produce a combined stream and the combined stream is passed through the microchannel. The microchannel reactor includes a heat transfer system. The hydrocarbon fuel and oxygen-containing gas are contacted in the microchannel in the presence of the catalyst at a reaction temperature sufficient to produce a reformed hydrocarbon fuel having a cetane value greater than a cetane value of the starting hydrocarbon fuel.Type: GrantFiled: December 14, 2022Date of Patent: June 18, 2024Assignee: Saudi Arabian Oil CompanyInventors: Guanghui Zhu, Maryam M. Al-Taher, Christos Kalamaras
-
Patent number: 12012559Abstract: A Janus membrane exhibiting sides with different properties and methods of fabricating such a Janus membrane. The membrane comprises a polymer material lacking polar functional groups. One side of the membrane is masked during atomic layer deposition (ALD). ALD is utilized to deposit a conformal coating on an exposed side of the membrane.Type: GrantFiled: May 11, 2018Date of Patent: June 18, 2024Assignee: UCHICAGO ARGONNE, LLCInventors: Ruben Waldman, Hao-Cheng Yang, Seth B. Darling
-
Patent number: 12012560Abstract: The present invention refers to the processing of a 100% renewable load in FCC units, wherein the load comprises triglycerides of vegetable and animal source, free fatty acids, fatty acid esters, ketones, alcohols and long-chain aldehydes, using catalyst and appropriate operating conditions in order to obtain 100% renewable products with a high content of aromatic compounds, in the range of naphtha, kerosene, diesel and heavy gas oil. The product thus obtained complies with all the properties of the ASTM D1655 standard, even for contents of up to 10% renewable content. In addition, there is no need to reduce the freezing point of the fossil QAV for the introduction of the renewable component, with no impact on the yield and economy of the process.Type: GrantFiled: December 6, 2022Date of Patent: June 18, 2024Assignee: Petróleo Brasileiro S.A.—PetrobrasInventors: Jose Luiz Zotin, Marcelo Edral Pacheco, Rodrigo Caetano Chistone, William Richard Gilbert, Isa Santos Duarte, Andrea De Rezende Pinho, Jefferson Roberto Gomes
-
Patent number: 12012561Abstract: A method for producing an isoolefinic stream may include: oligomerizing an ethylene stream to a C4+ olefin stream in a first olefin oligomerization unit comprising a serial reactor and a lights removal column, wherein the C4+ olefin stream contains no greater than 10 wt % of methane, ethylene, and ethane combined; and wherein the ethylene stream contains at least 50 wt % ethylene, at least 2000 wppm ethane, no greater than 1000 wppm of methane, and no greater than 20 wppm each of carbon monoxide and hydrogen; and oligomerizing the C4+ olefin stream and a propylene/C4+ olefin stream in a second oligomerization unit to produce the isoolefinic stream.Type: GrantFiled: August 16, 2022Date of Patent: June 18, 2024Assignee: ExxonMobil Technology and Engineering CompanyInventors: Matthew J. Vincent, Keith H. Kuechler
-
Patent number: 12012562Abstract: A nonlimiting example method for producing a diesel boiling range composition comprises: oligomerizing an ethylene stream to a C4+ olefin stream in a first olefin oligomerization unit, wherein the C4+ olefin stream contains no greater than 10 wt % of methane, ethylene, and ethane combined in a first oligomerization; and wherein the ethylene stream contains at least 50 wt % ethylene, at least 2000 wppm ethane, no greater than 1000 wppm of methane, and no greater than 20 wppm each of carbon monoxide and hydrogen; oligomerizing the C4+ olefin stream and a propylene/C4+ olefin stream in a second oligomerization unit to produce an isoolefinic stream; wherein at least a portion of the isoolefinic stream is used to create the diesel boiling range composition.Type: GrantFiled: August 16, 2022Date of Patent: June 18, 2024Assignee: ExxonMobil Technology and Engineering CompanyInventors: Matthew J. Vincent, Keith H. Kuechler
-
Patent number: 12012563Abstract: Cracking furnace system for converting a hydrocarbon feedstock into cracked gas comprising a convection section, a radiant section and a cooling section, wherein the convection section includes a plurality of convection banks, including a first high temperature coil, configured to receive and preheat hydrocarbon feedstock, wherein the radiant section includes a firebox comprising at least one radiant coil configured to heat up the feedstock to a temperature allowing a pyrolysis reaction, wherein the cooling section includes at least one transfer line exchanger.Type: GrantFiled: June 19, 2020Date of Patent: June 18, 2024Assignee: TECHNIP ENERGIES FRANCE SAS.Inventors: Jelle Gerard Wijnja, Peter Oud
-
Patent number: 12012564Abstract: The present disclosure provides fuel additives including Mannich-based quaternary ammonium salt additives, fuel compositions including such additives, and Methods of improving performance of fuel injector using such additives.Type: GrantFiled: August 25, 2021Date of Patent: June 18, 2024Assignee: Afton Chemical CorporationInventors: Scott D. Schwab, Geeta Vadehra, Michel Nuckols
-
Patent number: 12012565Abstract: A composition comprising at least one fuel that is a diesel fuel, a biodiesel fuel, or combinations thereof and less than 100 ppm, less than 50 ppm (or less than 25 ppm, less than 10 ppm, 1 to 7 ppm, or 5 to 7 ppm) of an alkylene-coupled C10 to C60 (or C10 to C40, C14 to C32 or C24 to C28) alkylphenol; 25 to 500 ppm (or 50 to 500 ppm, or 150 to 450 ppm or 250 to 450 ppm, or 250 to 400 ppm) of a terpolymer; and 5 to 90 ppm, (or 10 to 70 ppm, to 60 ppm, or 10 to 55 ppm) of hydrocarbyl-substituted amine detergent having at least one tertiary amino group.Type: GrantFiled: October 1, 2020Date of Patent: June 18, 2024Assignee: The Lubrizol CorporationInventors: Jody A. Kocsis, Scott Capitosti, Thomas S. Corrigan, David J. Aaserud, Gregory Mathes, Anthony R. Frank, Elizabeth A. Schiferl, James C. Ray
-
Patent number: 12012566Abstract: A motor configured to power an electric or hybrid vehicle, comprising a lubricant oil composition including a polyalkylene glycol (PAG) base oil, at least one of a poly-alpha-olefin (PAO) and an ester, and an additive package that includes at least a sulfur-based extreme pressure agent.Type: GrantFiled: November 2, 2022Date of Patent: June 18, 2024Assignee: Idemitsu Kosan Co., Ltd.Inventors: Pedro Cawich, Takashi Yanagihara
-
Patent number: 12012567Abstract: A lubricating oil composition comprising a base oil, a zinc dialkyldithiophosphate, and a sarcosine derivate is described. The lubricating oil composition may comprise the zinc dialkyldithiophosphate at a concentration of 0.10 to 10 mass % and the sarcosine derivate at a concentration of 0.01 to 5.0 mass %. The lubricating oil composition may have a kinematic viscosity at 100° C. of 6.5 mm2/s or less, and can be used for lubricating a speed reducer.Type: GrantFiled: July 9, 2020Date of Patent: June 18, 2024Assignee: Idemitsu Kosan Co., Ltd.Inventor: Kazushige Matsubara
-
Patent number: 12012568Abstract: This invention relates to a functional fluid, comprising: (A) from 50 to 85 wt.-% of alkoxy glycol according to formula (I): CH3—O—(CH2—CH2—O)n—H, wherein n is a number from 2 to 5, with the proviso that in at least 30 wt.-% of all compounds according to formula (I), n is 3, and (B) from 1 to 20 wt.-% of alkoxy glycol according to formula (II): R1—O—(CH2—CH2—O)m—H, wherein R1 is a C2 to C8 alkyl residue, m is a number from 2 to 6, with the proviso that in at least 65 wt.-% of all compounds according to formula (II), m is 3, and (C) from 6 to 35 wt.-% of at least one compound according to formula (III): H—O—(CH2—CH2—O)k—H, wherein k is a number of 2 or higher, with the proviso that in at least 80 wt.-% of all compounds according to formula (III), k is 2 or 3, (D) at least one additive.Type: GrantFiled: December 2, 2020Date of Patent: June 18, 2024Assignee: Clariant International LtdInventor: Felix Hoevelmann
-
Patent number: 12012569Abstract: This invention relates to a functional fluid, comprising (A) from 70 to 90, preferably 75-87 wt.-% of alkoxy glycol according to formula (I) CH3—O—(CH2—CH2—O)n—H wherein n is a number from 2 to 5, with the proviso that in at least 30 wt.-% of all compounds according to formula (I) n is 3, and that 15 to 65 wt.-% of all compounds according to formula (I) have n=4 or 5, and (B) less than 1.0 wt.-% of alkoxy glycol according to formula (II) R1—O—(CH2—CH2—O)m—H wherein R1 is a C2 to C8 alkyl residue, m is a number from 2 to 6, (C) from 8 to 25, preferably 12-23 wt.-% of at least one compound according to formula (III) H—O—(CH2—CH2—O)k—H wherein k is a number of 2 or higher, with the proviso that in at least 80 wt.Type: GrantFiled: December 2, 2020Date of Patent: June 18, 2024Assignee: Clariant International LtdInventor: Felix Hövelmann
-
Patent number: 12012570Abstract: The present invention refers to acetates possessing woody creamy sandalwood olfactory properties. The invention further refers to fragrance compositions and consumer products comprising them.Type: GrantFiled: November 14, 2018Date of Patent: June 18, 2024Assignee: Givaudan SAInventors: Alain Bringhen, Simon Ellwood
-
Patent number: 12012571Abstract: A cleaning composition for removing cement-based residues from tiles, such as cementitious grout used for installing flooring and for filling the joints is presented. The composition includes: sulfamic acid, a glycol solvent, and water.Type: GrantFiled: September 21, 2019Date of Patent: June 18, 2024Assignee: FILA INDUSTRIA CHIMICA S.P.A. IN SIGLA FILA S.P.A.Inventor: Maria Antonia Soranzo
-
Patent number: 12012572Abstract: A chemical composition and method of making and using are provided for paint removal and/or for adhesive removal. The chemical composition comprises THF and a solvent selected from the group consisting of methyl acetate, acetone, dimethyl carbonate, propylene carbonate, and 1-chloro-4 (trifluoromethyl) benzene, and a combination thereof.Type: GrantFiled: October 8, 2018Date of Patent: June 18, 2024Assignee: W.M. Barr & Company, Inc.Inventors: Charles L. Hawes, Tim Teague
-
Patent number: 12012573Abstract: The present invention relates to compositions such as cleaning compositions comprising a mix of enzymes, in particular a dispersin and a protease. The invention further relates to use of compositions comprising such enzymes in cleaning processes.Type: GrantFiled: July 2, 2019Date of Patent: June 18, 2024Assignee: Novozymes A/SInventors: Rune Nygaard Monrad, Rebecca Munk Vejborg, Jesper Salomon, Dorotea Raventos Segura
-
Patent number: 12012574Abstract: The present invention relates to a process for removing dry surface biofilm from a surface. The process comprises: (i) dissolving a powder-based composition into water wherein the powder-based composition comprises: a) a hydrogen peroxide source, b) an acetyl donor, c) an acidifying agent, and d) a wetting agent; (ii) allowing the solution to generate a biocidally effective concentration of peracetic acid; (iii) contacting the dry surface biofilm contaminated surface with the solution of peracetic acid for a period of time; and (iv) removing the solution.Type: GrantFiled: November 7, 2018Date of Patent: June 18, 2024Assignee: Whiteley Corporation Pty. Ltd.Inventors: Trevor Owen Glasbey, Gregory Stuart Whiteley
-
Patent number: 12012575Abstract: The present invention provides a means capable of improving a residue removing effect and improving storage stability in a composition for surface treatment which is used for reducing residues on a surface of an object to be polished after being polished chemical mechanical polishing. The present invention relates to a composition for surface treatment, wherein the composition contains a solvent and a dissolved gas, a concentration of the dissolved gas is 0.01 mg/L or more and 10 mg/L or less with respect to a total volume of the composition and the composition is used for reducing residues on a surface of an object to be polished after being polished by chemical mechanical polishing.Type: GrantFiled: January 6, 2020Date of Patent: June 18, 2024Assignee: FUJIMI INCORPORATEDInventors: Keita Suzuki, Yohei Takahashi
-
Patent number: 12012576Abstract: A device for infusing flavor into liquids fits and seals to the neck of a bottle. The device has an infusing chamber that is selectively in fluid communication with the liquid in the bottle. The infusing chamber holds a replaceable infusing material that partially dissolves and infuses flavor as liquid passes over it. A check ball selectively separates the infusing chamber from the liquid in the bottle to prevent any infused liquid from returning to the bottle. The device has a passage for makeup air to enter the bottle as infused liquid is dispensed. The infusing material is replaceable by accessing the infusing chamber.Type: GrantFiled: May 5, 2021Date of Patent: June 18, 2024Inventor: Charles Woods
-
Patent number: 12012577Abstract: A system and method adapted for continuous growth and harvesting of fungal fruiting bodies. The system includes a growth chamber, one or more mycelium feed assemblies, a nutrient reservoir with liquid media, one or more environmental controls to control an environment within the growth chamber and of the liquid media within the nutrient reservoir. One or more mycelium feed assemblies are arranged within the growth chamber. Each of the one or more mycelium feed assemblies includes a nutrient supply member and a mycelium colony which grows around the nutrient supply member, that continuously supplies liquid media to the mycelium colony. The method includes starting one or more mycelium colonies on the nutrient supply member, establishing that a mature colony has formed, and then maintaining the mature mycelium colony by continuous delivery of liquid medium to the mycelium colony, thus allowing for contiguous generation and harvesting of fungal fruiting bodies.Type: GrantFiled: April 20, 2023Date of Patent: June 18, 2024Inventors: Edward Dale, Natalie Dale, Nicolaas Vermeulen
-
Patent number: 12012578Abstract: One aspect of the invention provides a system for dispensing and printing cells and particles. The system includes: (a) a flow confinement device; (b) a controller configured to generate a confined liquid volume outside the flow confinement device, wherein the confined liquid volume or materials contained in the confined liquid volume can be released to the environment by confined, modulated, and non-confined flow modes in arbitrary sequence and for arbitrary periods of time by said controller; (c) one or more liquids containing cells or cell constituents supplied into the confined liquid volume through the flow confinement device; (d) a substrate; and (e) a system configured to position the flow confinement device in 3D space and, therefore, the confined liquid volume to be positioned relative to the substrate, such that the confined liquid volume and contents, can interact with the substrate.Type: GrantFiled: January 28, 2020Date of Patent: June 18, 2024Assignee: Fluicell ABInventors: Owe Orwar, Alar Ainla, Gavin David Michael Jeffries, Shijun Xu
-
Patent number: 12012579Abstract: A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.Type: GrantFiled: October 10, 2022Date of Patent: June 18, 2024Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Clinton C. Staheli, Nephi D Jones, Michael E. Goodwin
-
Patent number: 12012580Abstract: An analyzing system for pesticide effectiveness includes a transparent container having an interior area, the transparent container having a port extending through a wall of the transparent container; a bracket positioned within the interior are of the transparent container; a dish having a dish interior area configured to hold a test insect, the dish to be supported by the bracket within the transparent container; an injection device to inject a test liquid into the interior area of the transparent container through the port; the dish is to hold the test insect a distance from an injected test liquid; and the transparent container provides for visual observations of an effect of the test liquid on the test insect.Type: GrantFiled: May 21, 2021Date of Patent: June 18, 2024Inventors: Peng Xu, Li Cheng
-
Patent number: 12012581Abstract: The invention relates to a method for the simultaneous heterotrophic and mixotrophic cultivation of microalgae, to a system for the simultaneous heterotrophic and mixotrophic cultivation of microalgae and to the use of the method and/or the system for the cultivation of microalgae.Type: GrantFiled: October 8, 2018Date of Patent: June 18, 2024Assignee: GICON Grossmann Ingenieur Consult GmbHInventors: Jochen Grossmann, Fritz Cotta, Martin Ecke
-
Patent number: 12012582Abstract: A conjugation device includes at least one flow reactor having an inlet and an outlet, the flow reactor(s) being completely filled with a support such as a matrix including 1) chromatography beads, fibers or membranes, and 2) a biologic catalyzer, namely the enzyme ligase, which is immobilized onto this support; a fluid delivery unit in fluid communication with the inlet of the flow reactor(s) and configured to continuously provide the flow reactor(s) with at least one kind of reaction fluid such as antibody and linker-payload according to stages of the conjugation process, the at least one kind of process fluid including a first moiety and a second moiety of a conjugate to be produced; and a fluid collection unit in fluid communication with the outlet of the flow reactor(s) and configured to control collection of fluid flowing out of the outlet of the flow reactor(s) according to the stages of the conjugation process.Type: GrantFiled: January 5, 2023Date of Patent: June 18, 2024Assignees: GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD., LISURE SCIENCE (SUZHOU) CO., LTDInventors: Gang Qin, Sheng Zhou, Cao Lv, Joachim Walter
-
Patent number: 12012583Abstract: A bioreactor configured for stimulation of a plurality of samples includes a well plate containing a plurality of chambers and a cover placed over the well plate. A plurality of fixed arms are located in the cover, each chamber of the plurality of chambers having a fixed arm located therein. A plurality of moving arms are located in the cover, each chamber of the plurality of chambers having a moving arm located therein. The moving arm and fixed arm of each chamber hold a sample therebetween. A moving arm shaft is located in the cover, and is operably connected to the plurality of moving arms. An electrical motor is located outside of the cover and is operably connected to the moving arm shaft. The electrical motor is configured to drive movement of the plurality of moving arms relative to the plurality of fixed arms via the moving arm shaft.Type: GrantFiled: February 16, 2021Date of Patent: June 18, 2024Assignee: WESTERN NEW ENGLAND UNIVERSITYInventors: Devina Jaiswal, Brennen Zolnoski, Emily Fernschild
-
Patent number: 12012584Abstract: There is disclosed a cell culture plate comprising at least two sequentially arranged wells and a channel adapted for fluid communication between the wells, wherein the channel is connected or coupled to a first pump via openings at each end of the channel, and wherein said first pump is operable to circulate fluid between the at least two wells. Devices and systems incorporating the cell culture plate and methods and uses employing same are also disclosed.Type: GrantFiled: August 30, 2018Date of Patent: June 18, 2024Assignee: Philip Morris Products S.A.Inventors: David Bovard, Julia Hoeng, Shoaib Majeed, Antonin Sandoz
-
Patent number: 12012585Abstract: The disclosure provides systems and methods for producing a cannabinoid product, which comprises contacting a cannabinoid precursor in a first phase with a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible. The disclosure also provides a composition comprising the cannabinoid precursor in a first phase and a cannabinoid synthase in a second phase, wherein the first phase and the second phase are substantially immiscible or immiscible.Type: GrantFiled: March 21, 2022Date of Patent: June 18, 2024Assignee: Teewinot Life Sciences CorporationInventors: Richard Peet, Malcolm J. Kavarana, Mingyang Sun, Peter C. Michels, John D. Rabenstein, C. Seth Pearson, Geoffrey M. Fox
-
Patent number: 12012586Abstract: A hypoxic chamber system comprises a hypoxic chamber having: a housing, an internal receiving chamber formed within the housing, a lid operably connectable to the housing to seal the receiving chamber in a closed position, a first input and a second input in communication with the receiving chamber, and an oxygen sensor positioned in the receiving chamber; a first regulator valve operatively connected to the first input and an oxygen source; a second regulator valve operatively connected to the second input and a non-oxygen source; and a controller electrically connected to the first regulator valve, the second regulator valve, and the oxygen sensor.Type: GrantFiled: October 29, 2020Date of Patent: June 18, 2024Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventors: Kytai Truong Nguyen, Alan Nguyen, Harish Ramachandramoorthy, Daniel To, Dylan Yu
-
Patent number: 12012587Abstract: An improved bacterial oil treatment composition or pool for handling a decommissioned oil cable, which may be laid in particular as part of a power grid in the ground. The invention further relates to a bacteria growth culture medium containing the bacterial oil treatment composition for refurbishing an oil cable and a corresponding use.Type: GrantFiled: July 29, 2020Date of Patent: June 18, 2024Assignee: TIBIO SAGLInventors: Davide Staedler, Thibaud Spinetti, Marco Torriani
-
Patent number: 12012588Abstract: The invention relates to the novel use of photosynthetic microorganisms to allow for the generation of micron-scale optical output mechanical sensors. In one preferred embodiment, the invention includes systems, methods and compositions for the use of photosynthetic microbes as biologically-based micron-scale tunable, light/chemical-mechanical energy transducers, sensors, and/or actuators.Type: GrantFiled: July 16, 2018Date of Patent: June 18, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Jeffrey Carlyle Cameron, Kristin A. Moore, Evan B. Johnson, Jian Wei Tay, Janet B. Fox, Sabina Altus, David Bortz
-
Patent number: 12012589Abstract: The present invention provides a Lactobacillus composition and a use thereof for improving anxiety caused by antibiotics, wherein the Lactobacillus composition comprises Lactobacillus plantarum GMNL-141, Lactobacillus rhamnosus GM-020, Lactobacillus acidophilus GMNL-185, or a combination thereof. The Lactobacillus composition can effectively improve imbalance of an individual's intestinal flora caused by antibiotics to help stabilize and increase species richness and increase the synthesis of mood-stabilizing compounds, including flavonoids, flavonols, isoquinoline alkaloids, niacinamide, nicotinamide, and short-chain fatty acids in intestine, and thus effectively improve antibiotic-induced with anxiety disorders.Type: GrantFiled: December 23, 2021Date of Patent: June 18, 2024Assignee: GENMONT BIOTECH INCORPORATIONInventors: Wan-Hua Tsai, Wen-Ling Yeh, Chia-Lin Wu, Chih-Ho Lai, Yao-Tsung Yeh, Cheng-Hsieh Huang
-
Patent number: 12012590Abstract: It relates to Bacillus velezensis, a culture method and use thereof; Bacillus velezensis TA-3-BV serving as an endogenous antagonistic strain of sweet cherry for the first time, and a nucleotide sequence of 16S rDNA of the Bacillus velezensis TA-3-BV is shown as SEQ ID NO. 1. The Bacillus velezensis TA-3-BV has board-spectrum antibacterial activity for sweet cherry, has an inhibitory effect on a variety of pathogenic fungi, and especially has an excellent inhibitory effect on Rhizopus stolonifer serving as a soft rot pathogen of sweet cherry, with an inhibition rate of 69.82±1.43%; in addition, the Bacillus velezensis TA-3-BV has a good inhibitory effect on the postharvest rot of sweet cherry fruits, can slow down the rot process of fruits, can delay the rot of fruits by 2-3 d, thereby providing a novel method for postharvest preservation of sweet cherry.Type: GrantFiled: July 15, 2021Date of Patent: June 18, 2024Assignee: SHANDONG INSTITUTE OF POMOLOGYInventors: Qian Zhang, Li Xin, Yilun Chen, Peng Wu, Liangqing Xi, Yushi Chen, Man Zou, Juanxia Yang
-
Patent number: 12012591Abstract: An apparatus and methods are provided for the magnetic separation of target bioentities. The apparatus includes a fluid chamber and a magnetic element for drawing target bioentities toward a collection surface of the fluid chamber. The apparatus may include a positioning assembly operable to variable change the position and orientation f the fluid chamber relative to the magnetic element.Type: GrantFiled: May 10, 2021Date of Patent: June 18, 2024Assignee: Biomagnetic Solutions LLCInventors: Paul A. Liberti, Todor R. Khristov, Dustin W. Ritter
-
Patent number: 12012592Abstract: The present invention relates to an extraction apparatus capable of simultaneously extracting target materials from multiple biological samples and, more particularly, to a target material extraction apparatus in which magnetic bar blocks can be replaced according to kinds of multi-well plates to be inserted into a cartridge. When used, the target material extraction apparatus of the present invention is operated in such a manner that among various plates multi-well having different numbers of wells, multi-well plates suitable for a use purpose are loaded into a cartridge within the apparatus and magnetic bar blocks equipped with magnetic bars suitable therefor are selected and loaded. Thus, the apparatus has the advantage of selectively applying various multi-well plates to one installment according to the number of samples from which a target material is extracted or to the amount of the target material to be extracted.Type: GrantFiled: July 23, 2019Date of Patent: June 18, 2024Assignee: BIONEER CORPORATIONInventors: Han-Oh Park, Min Sung Kook
-
Patent number: 12012593Abstract: The invention refers to a replicable genetic package displaying a peptide having at least one intramolecular cyclic bond between two heteroatoms of amino acid side chains, a method of preparing a replicable genetic package, a method of producing a library and a library of replicable genetic package.Type: GrantFiled: April 25, 2022Date of Patent: June 18, 2024Assignee: Miti Biosystems GmbHInventor: Guntram Christiansen
-
Patent number: 12012594Abstract: Various approaches for generating read-sets from nucleic acid molecules and segments and phasing are disclosed. Nucleic acids are assembled into complexes using binding moieties and exposed nucleic acid ends are tagged with nucleic acid tags. Read-sets can be generated from tagged nucleic acid molecules and segments. Physical linkage relationships between nucleic acid molecules and segments can be examined using the nucleic acid tags. Various approaches to generating read-sets and phasing are presented.Type: GrantFiled: April 14, 2022Date of Patent: June 18, 2024Assignee: The Regents of the University of CaliforniaInventor: Daniel S. Rokhsar
-
Patent number: 12012595Abstract: An improved peptide library preparation method is described for constructing complete peptide libraries such as a complete tripeptide library, tetrapeptide library, pentapeptide library, hexapeptide library, heptapeptide library, or a complete octapeptide library, etc. The method includes constructing an expression vector for the expression of tagged peptides. Each tagged peptide contains an array of peptides of different sizes, and the number of peptides in a complete peptide library can be dramatically reduced relative to conventional chemical peptide synthesis. Furthermore, the libraries can be readily reproduced. The improved peptide library preparation method can particularly be used, for example, to construct a complete pentapeptide library. Other related methods and related expression vectors are also described.Type: GrantFiled: July 3, 2015Date of Patent: June 18, 2024Assignee: HUNAN ZONSEN PEPLIB BIOTECH CO., LTDInventors: Zhuying Wang, Xiangqun Li
-
Patent number: 12012596Abstract: Provided is a method for targeting a target nucleotide sequence. The method includes introducing, into a cell: (i) CRISPR type I-D related proteins Cas5d, Cas6d, and Cas7d, or nucleic acids encoding these proteins; and (ii) a guide RNA which includes a sequence complementary to said target nucleotide sequence and common repetitive sequences derived from CRISPR gene locus before and after said complementary sequence, or a DNA encoding said guide RNA.Type: GrantFiled: August 20, 2018Date of Patent: June 18, 2024Assignee: Tokushima UniversityInventors: Keishi Osakabe, Yuriko Osakabe