Abstract: Provided is a method of diagnosing the degradation of a lithium secondary battery in a non-destructive manner without disassembling the battery, which includes: obtaining, from X-ray diffraction (XRD) data obtained during first charging of the lithium secondary battery, a first graph showing the change of the c-axis d-spacing value of the layered positive electrode active material according to the number of moles of lithium ions deintercalated from the layered positive electrode active material during the charging; obtaining, from XRD data obtained during second charging of the lithium secondary battery, a second graph showing the change of the c-axis d-spacing value of the layered positive electrode active material according to the number of moles of lithium ions deintercalated from the layered positive electrode active material during the charging; and classifying a cause of degradation of the secondary battery by comparing the first graph and the second graph.

Abstract: The present disclosure an improved apparatus for fast pyrolysis and methods associated with the apparatus. For instance, the present disclosure provides methods for analyzing intermediate products formed via a fast pyrolysis reaction utilizing one or more pulses of pyrolysis vapor through a valve in the apparatus. The described methods provide improved identification of products formed in the fast pyrolysis reaction by using millisecond time resolution for qualitative and/or quantitative analysis.

Abstract: A method for measuring thermal resistance between a thermal component of an instrument and a consumable includes contacting a known consumable with a thermal component to be tested; driving the thermal component using a periodic sine wave input based on a predetermined interrogation frequency; measuring temperature outputs from a thermal sensor responsive to the periodic sine wave input; multiplying the temperature outputs by a reference signal in phase with the periodic sine wave input and calculating the resultant DC signal component to determine an in-phase component X; multiplying the plurality of temperature outputs by a 90° phase-shifted reference signal and calculating the resultant DC signal component to determine a quadrature, out-of-phase component Y; calculating a phase offset responsive to the periodic sine wave input based on tan?1 (Y/X) or atan2(X,Y); and determining a resistance value for the thermal interface using a calibrated resistance-phase offset equation and the calculated phase offset.

Abstract: A system for determining a change of saturation of an adsorbent susceptible to adsorption of species in an adsorption chamber, the system comprising: an adsorbent-holding-ferrite-material cage; a cage holder configured to hold the cage within the adsorption chamber such that the movement of the cage at least in a first axis is restricted to a smaller extent than in a second axis; an exciter comprising a coil arranged at the cage, wherein the coil is connected to a voltage generator and the exciter is configured to induce eddy currents within the cage resulting in oscillation of the cage in the first axis; a spectrum analyzer connected to the coil and configured to analyze the voltage within the coil and determine its frequency response; and a saturation detector configured to determine the change of saturation based on the change of the frequency response determined by the spectrum analyzer.

Abstract: A sensing device includes at least one vibration sensor that responds to sensed vibrations. At least one drive-sense circuit is coupled to the vibration sensor, wherein the at least one drive-sense circuit includes: a first conversion circuit configured to convert a receive signal component of a sensor signal corresponding to the at least one vibration sensor into the sensed signal, wherein the sensed signal indicates a change in an electrical characteristic associated with the at least one vibration sensor; and a second conversion circuit configured to generate, based on the sensed signal, a drive signal component of the sensor signal corresponding to the at least one vibration sensor.

Abstract: An apparatus to detect a liquid in a wafer processing device includes a first conductor proximate the wafer processing device. The apparatus includes a second conductor spaced apart from the first conductor and proximate the wafer processing device. The apparatus includes a liquid absorption material surrounding the first conductor and the second conductor. The apparatus includes a current source coupled to the first conductor. The apparatus includes a current detector coupled to at least one of the first conductor or the second conductor. The liquid absorption material establishes a conductive pathway between the first conductor and the second conductor when the liquid absorption material absorbs the liquid in the wafer processing device. A current is generated, by the current source, in at least one of the first conductor or the second conductor through the conductive pathway. The current detector detects the current.

Abstract: A combustible gas sensor that includes a reference sensor. The reference sensor includes a first substrate having a first substrate first surface, a first insulating layer disposed on the first substrate first surface, and a first heater at least one of embedded within the first insulating layer and disposed on the first insulating layer. The first substrate is a MEMS substrate.

Abstract: Described are various embodiments of a system and method for selectively identifying the presence of a designated chemical species within a chemical sample using a two-dimensional sensor, which, when exposed to illumination, provides a differentiable adsorption sensor response signal for chemical identification.

Abstract: Provided are a virus measuring method, a virus measuring device, a virus determining program, a stress determining method, and a stress determining device. A virus measuring method includes a contact step of bringing a liquid specimen containing a body fluid of a subject and an electrolytic solution into contact with each other via a through-hole portion formed in a separating wall, a current measuring step of applying a voltage to the liquid specimen and the electrolytic solution with respect to the through-hole portion and obtaining a waveform of an ionic current flowing through the through-hole portion, and a virus determining step of determining the kind of a virus contained in the body fluid on the basis of the waveform. In the virus determining step, the kind of the virus is determined by comparing the waveform with waveform information that corresponds to a known virus and is obtained beforehand.

Abstract: Ion selective membranes and the preparation thereof, such as magnesium ion selective membranes and the preparation thereof. In particular, the invention describes improved PVC polymer blends for use in ion selective membranes. The invention furthermore relates to electrodes and potentiometric sensors comprising such membranes and the use thereof for determining ion concentrations in samples.

Abstract: A monolithic, three-dimensional (3D) integrated circuit (IC) device includes a sensing layer, a memory layer, and a processing layer. The sensing layer includes a plurality of carbon nanotube field-effect transistors (CNFETs) that are functionalized with at least 50 functional materials to generate data in response to exposure to a gas. The memory layer stores the data generated by the plurality of CNFETs, and the processing layer identifies one or more components of the gas based on the data generated by the plurality of CNFETs.

Abstract: An embodiment provides a method for measuring at least one characteristic of an aqueous sample, including: introducing an aqueous sample into a measurement device comprising one or more electrodes; oxidizing a transition metal to produce a higher valent metal by applying an electrical potential between an anode and a cathode of the measurement device; oxidizing, using the higher valent metal as a catalyst, a material within the aqueous sample; measuring a characteristic of the aqueous sample based upon the oxidized material, using a measurement device selected from the group consisting of: an electrochemical measurement device and an optical measurement device; and optimizing the electrical potential and at least one reagent delivered to the measurement device based on the measurement of the characteristic. Other aspects are described and claimed.

Abstract: A capillary electrophoresis apparatus is disclosed that does not discharge and achieves both compactness and performance even with a part configuration having insufficient spatial distance or creeping distance. This capillary electrophoresis apparatus is provided with a resistance heater for heating capillaries, an electrode holder that holds capillary electrodes and is connected to a high-voltage unit, and a conductive member that at least partially comprises metal and has been grounded to a low potential. The electrode holder and conductive member are in contact with heat-dissipating rubber disposed there between that composes a structure comprising an insulation member. As a result of this configuration, discharge risk is reduced through the reduction of the potential of parts near the high-voltage unit and the slow reduction of the high potential of the high-voltage unit.

Abstract: Aspects of the subject technology relate to systems, methods, and computer-readable media for accounting for artifacts in pipe measurements made by an electromagnetic pipe inspection tool. Measurements gathered in a plurality of pipes across different depth points are accessed. Initial estimates of an attribute associated with the plurality of pipes are made for each pipe and a total estimate of the attribute for the plurality of pipes as a whole are made across the different depth points. Corresponding initial estimates of the attribute for each pipe are filtered to remove an artifact present in at least one of the corresponding initial estimates while the total estimate is preserved. Corresponding final estimates of the attribute for each pipe are determined based on both the measurements and corresponding filtered initial estimates of the attribute for each pipe. Integrity of each pipe can be determined based on the corresponding final estimates of the attribute.

Abstract: A robotic cleaning appliance includes a sonic transducer and a processor coupled with a housing. The sonic transducer transmits sonic signals toward a surface within its ringdown distance and receives corresponding returned signals. Following cessation of the sonic signals, the processor samples the ringdown signal generated by the sonic transducer during an early portion before the corresponding returned signals have reflected back to the sonic transducer, and during a later portion which includes the corresponding returned signals. The processor utilizes the sampled early portion to estimate a void ringdown signal of which represents performance of the sonic transducer in absence of returned signals being received. The processor compares the estimated void ringdown signal to the later portion of the ringdown signal and generates a metric based on the comparison. The processor utilizes the metric to determine a type of the surface, out of a plurality of surface types.

Abstract: A method and system are described for examining the interior material of an object from a surface of an object, using ultrasound having a frequency of at least 100 kHz. The method comprises the step of transmitting at least a first ultrasound signal by a first ultrasound transmitter of a first number of ultrasound transmitters to the interior material of the object for forming a first image in order to determine, according for example to the principle of inverse wave field extrapolation, where in the interior material of the object reflections and/or diffractions occur. Reflections and/or diffractions of the first ultrasound signal from the interior material of the object are received using a second number of ultrasound receivers which are acoustically coupled to the surface of the object at positions which are distributed in at least one dimension of the surface of the object.

Abstract: Using various techniques, a position of a probe assembly of a non-destructive inspection system, such as a phase array ultrasonic testing (PAUT) system, can be determined using the acoustic capability of the probe assembly and an inertial measurement unit (IMU) sensor, e.g., including a gyroscope and an accelerometer, without relying on a complex encoding mechanism. The IMU sensor can provide an estimate of a current location of the probe assembly, which can be confirmed by the probe assembly, using an acoustic signal. In this manner, the data acquired from the IMU sensor and the probe assembly can be used in a complementary manner.

Abstract: A method includes forming, by a laser beam supplied by a laser cutting system, a laser-cut line in each of a plurality of glass samples. Each different laser-cut line in each different glass sample of the plurality of glass samples is formed when the laser cutting system is at a different process setting. The method also includes subjecting each of the plurality of glass samples with the laser-cut lines to a break test, and obtaining a plurality of break strength values. Each different break strength value of the plurality of break strength values is indicative of a laser-cut line quality of the respective glass sample of the plurality of glass samples.

Abstract: The present invention relates to transmission elements (1, 1a, 1b; 12, 12a, 12b) for testing/determining the tensile or shear strength of a bonding between two elongated shaped specimen elements by transmitting a tensile or shear force (10, 22) to a specimen element (5a, 5b; 12a, 12b).

Abstract: A sensor device for detecting static modulus of elasticity in situ comprising: top and bottom frame end plates, said top and bottom frame end plates connected by at least two frame side bars; a dry cavity connected to said top frame end plate comprising a piston, precompression mechanism, and piston transfer plate; a displacement measurement gauge extending from said dry cavity along a longitudinal axis of said sensor device having a first end in contact with said piston transfer plate and a second end in contact with a bottom inner face of said bottom frame end plate; and a top inner face connected to said piston transfer plate, wherein a portion of elastomeric material is positioned on said bottom and top inner faces, said elastomeric material positioned to prevent contact with either bottom or top inner faces except for a portion along the longitudinal axis of the displacement measurement gauge.

Abstract: A bending apparatus for a sample is disclosed. The bending apparatus includes a translation mechanism that translates a vertical displacement/force into a horizontal displacement/force for bending. Components of the bending apparatus are fabricated from a strong, radiolucent material. In these ways, the bending apparatus is compatible with micro-CT imaging, and as such, may be used to bend a sample during imaging. In a particular application, the bending apparatus may be used to measure biomechanical properties of a bone, such as bone strength, bone material properties, fracture toughness, and fracture propagation.

Abstract: A gas chromatograph main body (2) comprising an upper surface on which a plurality of injection ports are provided, an injector (4A) arranged on the gas chromatograph main body (2), for corresponding to an injection port (10-1 to 10-4) optionally selected from a plurality of the injection ports (10-1 to 10-4), and being configured to inject a sample through the corresponding injection port (10-1 to 10-4), and a sampler (6) for supplying a vial containing liquid to the injector (4A). The sampler (6) is arranged at a position determined according to a position of the injector (4A) on the gas chromatograph main body (2) so as to have a specific positional relationship with the injector (4A). The sampler is engaged with the gas chromatograph main body (2) or the injector (4A).

Abstract: A seal pack of a sample manager of a liquid chromatography system having a plurality of wash flow pathways fluidically connected to a central pathway that accommodates a sample needle, wherein a first wash flow pathway is vertically offset from a second wash flow pathway, such that a wash solution flows axially along an exterior surface of the sample needle in a vertical direction to wash the sample needle when flowing from the first wash flow pathway to the vertically offset second wash flow pathway, is provided. Furthermore, an autosampler and associated methods are also provided.

Abstract: The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system. The chromatography system includes a mobile phase pump configured to pump a liquid mobile phase through a column and a restrictor positioned downstream of the column and upstream of a detector. The system also includes a valve configured to operate in at least two positions. In a first position, the valve is configured to direct the output of the column to bypass the valve and reach the detector, while in the second position the valve directs the output of the column to waste.

Abstract: A gas phase component analysis device and a gas phase component analysis method that can prevent degradation of the device due to an unnecessary component and can obtain excellent detection sensitivity are provided. A gas phase component analysis device (1) includes a heating unit (2) configured to heat a specimen to generate a gas phase component composite, a first column (31) into which the gas phase component composite is introduced, a second column (32) that is a separation column connected with the first column (31) through a connection unit (33), an isothermal oven (3) housing the first column (31), the second column (32), and the connection unit (33), a detection unit (4) configured to detect a gas phase component having passed through the second column (32), and a suction unit (5) connected with the connection unit (33).

Abstract: A reconfigurable capillary liquid chromatography system includes a solvent delivery manager including a first solvent pump assembly including a first pump housing or mount. A base module is further provided including a base module housing which is user accessible, or a base module bracket, and an injection valve for sample injection to a liquid chromatography column. The injection valve has an inlet port for receiving a sample and the injection valve is mounted in or on the base module housing or the base module bracket. The solvent delivery manager is configured to deliver solvent to the injection valve. A reconfigurable control system is also provided for controlling the reconfigurable capillary liquid chromatography system.

Abstract: A gas sensing device comprises a sensing unit for sensing a target gas, the sensing unit comprising a carbon-based sensing layer which is sensitive to the target gas. The gas sensing device further comprises a controller unit for monitoring an exposure of the sensing layer to the target gas. The controller unit further initializes a recovery sequence for the sensing unit depending on an exposure of the sensing unit to the target gas. Further, the gas sensing device comprises a heating electrode for heating the sensing layer during the recovery sequence.

Abstract: Disclosed herein is a method for manufacturing a hydrogen sensor, the method comprising the steps of: disposing a thin film made of a transition metal or an alloy thereof on a surface of elastic substrate; applying a tensile force in a repetitive manner to the elastic substrate to form a nanocrack on the thin film disposed on the surface of the elastic substrate; and injecting hydrogen gas into the formed nanocrack and then removing the hydrogen gas to form a nanogap, wherein the tensile force in the step of forming a nanocrack is applied to an extent that the elastic substrate has a tensile strain of 25% to 100%.

Abstract: An interferometric fluid sensing system includes: a laser; a plurality of first fibre portions arranged to receive laser light from the laser; a second fibre portion configured to provide a reference arm for the interferometric fluid sensing system; and a detector arranged to receive light from the first and second fibre portions, wherein the laser light that passes through a void of each first fibre portion is caused to interfere with light passing through the second fibre portion at or before reaching the detector, wherein each of the first fibre portions is arranged such that that light passing through the void of each first fibre portion travels from the laser to the detector over a different path length from the light passing through the voids of the other first fibre portions.

Abstract: A sample processing and analyzing device for soil analysis in a karst area comprises a mounting unit, a processing unit arranged on the mounting unit, and an analyzing unit arranged on the mounting unit and connected with the processing unit through a feeding unit. The design of the damping component can control the grinding force to avoid sample crushing. The installation disc can be effectively clamped by the second axial moving component to move the sample position according to the grinding requirements, facilitating step-by-step polishing. The feeding unit sends the sample to the analysis unit through a conveyor belt for effective analysis. The sample processing and analyzing device can effectively process a soil concretion sample into a sample for analysis, has the advantages of easy operation, high degree of automation and high efficiency, and is suitable for mass popularization.

Abstract: Methods and a system for determining a composition of a fluid from a reservoir are provided. An exemplary method includes depressurizing a single-phase fluid to atmospheric pressure to separate a gas phase from a liquid phase, recording the volume of the gas phase, determining the weight of the liquid phase, and determining an atmospheric gas-oil ratio (GOR) from the volume of the gas phase and the weight of the liquid phase. The method also includes determining the composition of the gas phase to C9+, measuring the density of the liquid phase, determining the molecular weight of the liquid phase, and determining the composition of the liquid phase to C45+. The total hydrocarbon composition of the fluid is calculated from the amount of the gas phase, the amount of the liquid phase, the composition of gas phase, the composition liquid phase, and the atmospheric GOR.

Abstract: The present invention provides an in-vitro method for analyzing a cell composition comprising human floorplate mesDA progenitor cells, the method comprising a) contacting the cells of said cell composition or the cells of a sample thereof with antigen binding molecules specific for the antigens FOXA2, OTX2, PAX6, and NKX6.1, thereby labeling the cells of said cell composition or of said sample, b) determining the percentage of said cells that are labelled with said antigen binding molecules for each of said antigens, and wherein the cells of said cell composition qualify as human floorplate mesDA progenitor cells if the protein expression profile of said cells is: 80-100% of said cells are positive for FOXA2, 80-100% of said cells are positive for OTX2, less than 10% of said cells are positive for PAX6, and less than 10% of said cells are positive for NKX6.1. A kit comprising said antigen binding molecules for use in said method is also provided.

Abstract: The present invention provides a method of evaluating pathological conditions of heart failure based on a new mechanism of action of heart failure, a method of evaluating a candidate compound for a heart failure treatment drug using the mechanism of action, and a pharmaceutical composition for treating or preventing heart failure using the mechanism of action. That is, the present invention provides a method of evaluating pathological conditions of heart failure including measuring an amount of succinyl-CoA in cardiomyocytes collected from a test animal, a respiratory capacity of mitochondrial complex II in peripheral blood mononuclear cells collected from the test animal or an amount of reactive oxygen species released from peripheral blood mononuclear cells collected from the test animal; and evaluating the onset of heart failure of the test animal or the severity of heart failure based on the obtained measurement values.

Abstract: The present application discloses a nucleic acid composition for expressing recombinant EBIV-related genes and proteins and the use thereof. The nucleic acid composition includes a nucleic acid molecule having sequences shown in SEQ ID NO. 14, 15, 16, and 17. In the present application, a recombinant EBIV is also constructed with this nucleic acid composition. The virus not only has broad-spectrum infectivity to mammalian and mosquito cells, can be stably passaged, but also has green fluorescence, which can provide a research foundation for in vitro and in vivo virus tracing, virus detection, antiviral drugs, vaccine screening, with significant application prospects.

Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.

Abstract: Methods for proteomic screening on random protein-bead arrays by mass spec is described. Photocleavable mass tags are utilized to code a protein library (bait molecules) displayed on beads randomly arrayed in an array substrate. A library of probes (prey) can be mixed with the protein-bead array to query the array. Because mass spec can detect multiple mass tags, it is possible to rapidly identify all of the interactions resulting from this mixing.

Abstract: Provided is a method of preparing Raman-active nanoparticles, which includes a) preparing a metal nanocore having a nano-star shape from a first reaction solution in which a first metal precursor is mixed with a buffer solution; b) fixing a Raman reporter in the metal nanocore; and c) forming a metal shell, which surrounds the nanocore in which the Raman reporter is fixed, from a second reaction solution in which a second metal precursor is mixed with the nanocore in which the Raman reporter is fixed. The Raman reporter has a binding affinity for each of a first metal of the metal nanocore and a second metal of the metal shell.

Abstract: The present disclosure provides an immunochromatographic test piece which prevents a non-specific reaction by efficiently and continuously contacting and neutralizing a developing solution containing nitrous acid with a neutralizing reagent in an immunochromatography method of extracting and measuring a sugar chain antigen by nitrous acid extraction on the immunochromatographic test piece. The present disclosure also provides an immunochromatographic test piece for extracting and measuring a sugar chain antigen in a specimen, which comprises: a sample pad; a label region; a detection region on which the antibody against the sugar chain antigen is immobilized; a region impregnated with a neutralizing reagent upstream of the label region, and a region impregnated with a solid acid reagent or a region impregnated with nitrite, upstream of the region impregnated with the neutralizing reagent.

Abstract: A multiplexed vertical flow serodiagnostic testing device for diseases such as Lyme disease includes one or more multi-piece cassettes that include vertical stacks of functionalized porous layers therein. A bottom piece of the cassette includes a sensing membrane with a plurality of spatially multiplexed immunoreaction spots or locations. Top pieces are used to deliver sample and/or buffer solutions along with antibody-conjugated nanoparticles for binding with the immunoreaction spots or locations. A colorimetric signal is generated by the nanoparticles captured on the sensing membrane containing disease-specific antigens. The sensing membrane is imaged by a cost-effective portable reader device. The images captured by the reader device are subject to image processing and analysis to generate positive (+) or negative (?) indication for the sample. A concentration of one or more biomarkers may also be generated.

Abstract: Disclosed is a system and method for a microdevice to separate blood cells based on differences in antigen expression. Specifically, cells of the same phenotype are separated based on whether or not they are activated during infection or resting. The device of the present disclosure takes a small sample of blood and provides differential cell counts that can be used to test for infection and inflammatory response. The device can be used to identify sepsis and other infections rapidly. By measuring differences in activated white cell counts such as neutrophils, the device of the present disclosure measures physiological response to infection in hospitalized patients recovering from burns, surgeries, etc.

Abstract: A method of determining a prognosis for cancer in a subject and/or a subject with cancer includes measuring a level of proteolytically cleaved extracellular fragments of an immunoglobulin (Ig) superfamily cell adhesion molecule that is expressed by cancer cells obtained from the subject to determine at least one of prognosis for the cancer, the subject's survival, or responsiveness of the cancer to anti-cancer treatment.

Abstract: Embodiments of the instant disclosure relate to novel methods and compositions for distinguishing high-grade ductal carcinoma in situ (DCIS) from lower-grade DCIS in a breast tissue. Other embodiments of the instant disclosure provide for methods of administering one or more appropriate breast cancer treatment regimens to a subject diagnosed with high-risk DCIS.

Abstract: The present invention is to provide a method of exosome analysis that can analyze exosome in a sample in a simple manner. The method of exosome analysis of the present invention is a method of analyzing exosome in a sample, including: an addition step of adding a first antibody that specifically binds to a first antigen contained in the exosome and a second antibody that specifically binds to a second antigen contained in the exosome to the sample; a reaction step of causing the first antigen to be reacted with the first antibody and the second antigen to be reacted with the second antibody; and a detection step of detecting a reaction between the first antigen and the first antibody and a reaction between the second antigen and the second antibody.

Abstract: Flash Photo-Oxidation Device and Higher Order Structural Analysis is employed for higher order structural analysis of biomolecules. Biomolecular higher order structure (HOS) results from the confounded superimposition of a biomolecule's secondary, tertiary, and quaternary structure and defines the manner in which a biomolecule presents itself and interacts with other biomolecules in living systems. A rapidly growing class of therapeutic drugs, known as biotherapeutics, comprises a variety of proteins, whose therapeutic properties are inherently linked and dependent upon their HOS. As such, HOS analysis of biotherapeutics is an important analytical requirement in the biopharmaceutical industry.

Abstract: Flash Photo-Oxidation Device and Higher Order Structural Analysis is employed for higher order structural analysis of biomolecules. Biomolecular higher order structure (HOS) results from the confounded superimposition of a biomolecule's secondary, tertiary, and quaternary structure and defines the manner in which a biomolecule presents itself and interacts with other biomolecules in living systems. A rapidly growing class of therapeutic drugs, known as biotherapeutics, comprises a variety of proteins, whose therapeutic properties are inherently linked and dependent upon their HOS. As such, HOS analysis of biotherapeutics is an important analytical requirement in the biopharmaceutical industry.

Abstract: Methods, apparatuses and systems are described that are capable of simultaneously determining the presence, identities or levels of multiple analytes present in a single sample, by carrying out steps including denaturation, normalization, extraction, mixed-mode liquid chromatography and mass spectrometry, whereby the presence, identities or levels of analytes in the single sample are determined.

Abstract: Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy. Also provided are kits for detecting the amount of SMN protein in a sample of cerebrospinal fluid.

Abstract: The present disclosure relates to systems and methods for measuring glycated A1c hemoglobin. A glycated hemoglobin level measuring system includes a sample testing apparatus having a microchannel that compresses a blood sample traveling through, a first pair of electrodes coupled to the microchannel, and a second pair of electrodes coupled to the microchannel. The glycated hemoglobin level measuring system further includes an analysis apparatus having sensors coupled to the first and second pairs of electrodes and configured to calculate a travel time taken by a red blood cell to pass through the first and second pairs of electrodes. The glycated hemoglobin level measuring system can use the travel time to measure a rigidity of the red blood cells and the corresponding glycated hemoglobin level.

Abstract: A reagent composition for releasing vitamin D compounds bound to vitamin D-binding protein and an in vitro method for the detection of a vitamin D compound in which the vitamin D compound is released from vitamin D-binding protein by the use of this reagent composition as well as the reagent mixture obtained in this manner. Also disclosed is the use of the reagent compositions to release vitamin D compounds as well as a kit for detecting a vitamin D compound.

Abstract: Provided are methods, compositions and kits to detect anti-folic acid antibodies in a sample, which are useful for identifying risk of pathologies associated with increased or decreased levels of anti-folic acid antibodies including infertility, folate responsive birth defects, folate responsive blood disorders, heart and vascular diseases, neurological disorders, neurodegenerative diseases and cancers.