Patents Issued in June 25, 2024
  • Drill-in fluid compositions and methods
    Patent number: 12018206
    Abstract: Drill-in fluids disclosed herein comprise an aqueous base fluid, a viscosifier, a fluid loss control additive, and a degradable bridging agent comprising a degradable high strength polymetaphosphate material capable of undergoing an irreversible degradation downhole. The present disclosure further relates to a method for controlling fluid loss through a subterranean surface by using the drill-in fluid for form a filter cake on the subterranean surface. Also provided is a method of degrading a filter cake with an aqueous fluid or aqueous acidic fluid, wherein the filter cake is produced from the drill-in fluid. Further provided is a specific order of addition of constituents of the drill-in fluid, which results in improved filter cake performance and/or filter cake removal.
    Type: Grant
    Filed: December 5, 2022
    Date of Patent: June 25, 2024
    Assignee: LyondellBasell Advanced Polymers Inc.
    Inventors: Bradley L. Todd, Kristie Ince
  • Mitigation of transient gels in cements
    Patent number: 12018207
    Abstract: A cement slurry including graphene, a cement, and water; the graphene comprises bioderived renewable graphene (BRG). The cement slurry has reduced transient gel formation relative to a same cement slurry absent the graphene. Methods of mitigating transient gels in cement are also provided.
    Type: Grant
    Filed: August 22, 2022
    Date of Patent: June 25, 2024
    Assignee: Halliburton Energy Services, Inc.
    Inventors: Thomas Jason Pisklak, Samuel J. Lewis, Claudia Pineda
  • Method for unblocking a deep well plugged by an adsorbent
    Patent number: 12018208
    Abstract: A method is proposed for making geological deep wells that are clogged unblocked and capable of absorbing fluid again by adding an acid from the group of carboxylic acids and vinylogous carboxylic acids.
    Type: Grant
    Filed: May 25, 2022
    Date of Patent: June 25, 2024
    Assignee: EnBW Energie Baden-Württemberg AG
    Inventors: Thomas Kölbel, Elif Kaymakci, Laura Herrmann, Magdalena Graczyk-Zajac
  • Viscoelastic surfactant fluid composition, and method of using the same
    Patent number: 12018209
    Abstract: A viscoelastic surfactant fluid composition comprising: a surfactant: a counterion: and a modified nanoparticle.
    Type: Grant
    Filed: April 12, 2019
    Date of Patent: June 25, 2024
    Assignee: MITSUBISHI GAS CHEMICAL COMPANY, INC.
    Inventors: Kunitoshi Mimura, Rigoberto C. Advincula
  • Methods for stimulating a hydrocarbon-bearing formation by perforating a wellbore and introducing an acidic composition in the wellbore
    Patent number: 12018210
    Abstract: The invention includes methods for stimulating a hydrocarbon-bearing formation by perforating a wellbore and introducing an acidic composition in the wellbore. A preferred embodiment includes inserting an isolation plug in the wellbore at a predetermined location followed by inserting a perforating tool and a breakdown acid into the wellbore. The wellbore is perforated by the tool to create a perforated area. The breakdown acid is allowed to come into contact with the perforated area for a predetermined period of time sufficient to prepare the formation for stimulation. The tool is then removed from the wellbore wherein stimulation of the perforated area is thereby initiated. Also disclosed is a corrosion inhibiting composition for use with the acidic composition.
    Type: Grant
    Filed: December 20, 2022
    Date of Patent: June 25, 2024
    Assignee: DORF KETAL CHEMICALS FZE
    Inventors: Clay Purdy, Markus Weissenberger
  • Inverting surfactants for inverse emulsions
    Patent number: 12018211
    Abstract: Water-in-oil emulsions are provided that include an alkyl propylene diamine and an ethoxylated alcohol as the inverting surfactant, which is present in an amount less than 5 percent by weight of the water-in-oil emulsion.
    Type: Grant
    Filed: June 9, 2020
    Date of Patent: June 25, 2024
    Assignee: RHODIA OPERATIONS
    Inventors: Stanley Gunawan, Zhihua Zhang, Shaopeng Zhang, Igor Pimkov, Zhenxing Cheng, Qi Qu
  • Plastics pyrolysis process with quench
    Patent number: 12018212
    Abstract: A plastic catalytic pyrolysis process that can produce high yields of ethylene, propylene and other light olefins from waste plastics is disclosed. The catalytic product stream is quenched to below catalytic pyrolysis temperature quickly after exiting the reactor or bulk separation from the catalyst. Quench preserves selectivity of light olefinic monomers. The catalytic pyrolysis process can be operated in a single stage or a two-stage process.
    Type: Grant
    Filed: February 14, 2022
    Date of Patent: June 25, 2024
    Assignee: UOP LLC
    Inventors: David Gray, Scott Nauert, Yili Shi
  • Reactor feed systems
    Patent number: 12018213
    Abstract: A feed system for a reactor, a reactor assembly comprising such a feed system, and a method of supplying a feed material to a reactor with a feed system are provided. The reactor may be a pyrolysis reactor, such as a fluidised bed pyrolysis reactor. A method of pyrolysing a feed material is also provided. The feed system may comprise a feed conduit extending from an inlet to an outlet, and may have a first section including the inlet and a second section including the outlet. The first section may accommodate an auger. The second section may comprise at least one plug forming zone in which feed material is compressed into a substantially gas-tight plug during operation. There may be a temperature regulator for controlling the temperature in the second section. The temperature regulator may comprise a cooling jacket.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: June 25, 2024
    Assignee: Recycling Technologies Ltd
    Inventors: Marvine Besong, Colin Kedge
  • Method of providing a bio-oil to a hydrodeoxygenation reactor
    Patent number: 12018214
    Abstract: A method is disclosed for hydrodeoxygenation of a bio-oil over a catalyst bed in a hydrodeoxygenation reactor, the method including combining a two-phase diluent having a water dew point and a bio-oil at a bio-oil temperature that is from 50° F. less than to 50° F. more than the water dew point. The two-phase diluent includes a liquid phase and a vapor phase, where the liquid phase includes a hydrocarbon and the vapor phase includes hydrogen and water.
    Type: Grant
    Filed: March 2, 2021
    Date of Patent: June 25, 2024
    Assignee: REG Synthetic Fuels, LLC
    Inventors: Ramin Abhari, H. Lynn Tomlinson, Nathan Jannasch, Douglas Beshara, Jesse Haney, III, Cody Tidwell
  • Processes for direct conversion of crude oil to light olefins and light aromatics through steam enhanced catalytic cracking over a core shell cracking catalyst
    Patent number: 12018215
    Abstract: A process for converting a hydrocarbon feed may comprise contacting a hydrocarbon feed with steam in the presence of a cracking catalyst under steam enhanced catalytic cracking conditions. The contacting the hydrocarbon feed with the steam in the presence of the cracking catalyst may cause at least a portion of the hydrocarbon feed to undergo steam catalytic cracking reactions to produce a cracked effluent comprising C2 to C4 olefins, C6 to C10 aromatic compounds, or both. The cracking catalyst may be a nanoparticle comprising: a core and a shell. The core may comprise one or more ZSM-5 zeolite particles and have an outer surface. The shell may comprise a plurality of fibers extending radially outward from the outer surface of the core. The plurality of fibers may comprise silica.
    Type: Grant
    Filed: April 12, 2023
    Date of Patent: June 25, 2024
    Assignees: Saudi Arabian Oil Company, King Fahd University of Petroleum and Minerals
    Inventors: Aaron Chi Akah, Musaed Salem Al-Ghrami, Abdullah Mohammed Aitani, Mohammed Abdul Bari Siddiqui, Ziyauddin R. Qureshi
  • Methods and systems for enhancing processing of hydrocarbons in a fluid catalytic cracking unit using plastic
    Patent number: 12018216
    Abstract: Systems and methods are disclosed for enhancing the processing of hydrocarbons in a FCC unit by introduction of fluidized plastic at one or more locations of the FCC unit. In an embodiment, the method may include passing a coked FCC catalyst from a cyclone of the FCC unit to a regenerator. The method may include introducing at least oxygen and a fluidized plastic into the regenerator. The method may include combusting a combination of the fluidized plastic and a coke from the coked FCC catalyst in the regenerator, thereby to oxidize via the oxygen and produce a regenerated FCC catalyst and a flue gas. The method may include supplying the regenerated FCC catalyst from the regenerator to a riser of the FCC unit to crack the gas oil supplied to the riser of the FCC unit.
    Type: Grant
    Filed: June 16, 2023
    Date of Patent: June 25, 2024
    Assignee: MARATHON PETROLEUM COMPANY LP
    Inventors: Nikolas A. Larsen, Jeffrey A. Sexton
  • Method for producing a petrol with low sulfur and mercaptans content
    Patent number: 12018217
    Abstract: The present invention concerns a method for processing a petrol containing sulfur and olefin compounds, comprising the following steps: a) a step of hydrodesulfurisation in the presence of a catalyst comprising an oxide support and an active phase comprising a metal from group VIB and a metal from group VIII, b) a step of separating the H2S formed, c) a step of hydrodesulfurisation at a higher temperature than that of step a), with a hydrogen/feedstock ratio less than that of step a), and in the presence of a hydrodesulfurisation catalyst comprising an oxide support and an active phase consisting of at least one metal from group VIII, d) a step of separating the H2S formed.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: June 25, 2024
    Assignee: IFP ENERGIES NOUVELLES
    Inventors: Sophie Couderc, Adrien Gomez, Clementina Lopez Garcia, Philibert Leflaive, Damien Hudebine, Floriane Maldonado
  • Hydrocracking process for making middle distillate from a light hydrocarbon feedstock
    Patent number: 12018218
    Abstract: A two-stage hydrocracking process for preferentially making a high-quality middle distillate product such as diesel from a relatively light hydrocarbon feedstock such as light vacuum gas oil.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: June 25, 2024
    Assignee: SHELL USA, INC.
    Inventor: Michael Chiun-Kuei Hu
  • Crude oil transportation
    Patent number: 12018219
    Abstract: A method of improving the transportation of a crude oil which has been recovered from a crude oil well, the method comprising adding one or more glycerophospholipid(s) to a crude oil before and/or during the transportation of said crude oil.
    Type: Grant
    Filed: January 26, 2022
    Date of Patent: June 25, 2024
    Assignee: INFINEUM INTERNATIONAL LTD.
    Inventors: Nichola Kyle, Paul D. Kerby, Colin Morton, Michael S. Perryman
  • Thermal pyoil to a gas fed cracker furnace
    Patent number: 12018220
    Abstract: A predominantly C2 to C4 hydrocarbon cracker stream is combined with recycle content pyrolysis oil to form a combined cracker stream and the combined cracker stream is cracked in a cracker furnace to provide an olefin-containing effluent. The r-pyoil can be fed to a first coil while a second cracker feed with none of the r-pyoil or less of the r-pyoil is fed to a second coil, and both are cracked in a cracker furnace to form an olefin-containing effluent stream. Alternatively, the r-pyoil can be fed and distributed across multiple coils along with the non-recycle cracker feed. The furnace can be a gas fed furnace, or split cracker furnace. Further, a first cracker stream with r-pyoil in a first coil can have a lower total molar flow rate than a second cracker stream in a second coil in the same furnace.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: June 25, 2024
    Assignee: Eastman Chemical Company
    Inventors: Daryl Bitting, Kenny Randolph Parker, Michael Gary Polasek, David Eugene Slivensky, Xianchun Wu, Jerome Leonard Stavinoha, Jr.
  • Synthetic fuels, and methods and apparatus for production thereof
    Patent number: 12018221
    Abstract: Provided herein are systems and methods for converting CO2 and a reduction gas such as H2 or a hydrocarbon to mixtures of paraffins and aromatics suitable for use as aviation fuel.
    Type: Grant
    Filed: November 20, 2023
    Date of Patent: June 25, 2024
    Assignee: Air Company Holdings, Inc.
    Inventors: Lubo Zhou, Chi Chen, Qiyuan Wu, Stafford W. Sheehan, Namal de Silva, Mahluli Moyo, Jihad Dakka, David DeVilliers, Gregory Constantine, Mark Rumizen
  • Synthetic lubricity additives for hydrocarbon fuels
    Patent number: 12018222
    Abstract: Lubricity additives for hydrocarbon fuels are presented according to formula I: R1[(—O—R2)n-Q]p??(I) wherein p is 3 or greater; each n is independently selected from integers equal to 2 or greater; R1 is a C3-C20 aliphatic hydrocarbon group of valence p which is branched or linear and which is substituted or unsubstituted; each R2 is independently selected from C2-C20 divalent aliphatic or aromatic hydrocarbon groups which are branched or linear and which are substituted or unsubstituted; and each Q is independently selected from —NH2 or a moiety according to formula II: wherein each R3 is independently selected from C8-C60 alkenyl groups which are substituted or unsubstituted, providing that at least one Q is the moiety according to formula II.
    Type: Grant
    Filed: July 19, 2023
    Date of Patent: June 25, 2024
    Assignee: ECOLAB USA INC.
    Inventors: Ashish Dhawan, Xiaojin Harry Li, Nestor U. Soriano, Jr., Karina Eureste
  • Biofuel and method of biofuel production
    Patent number: 12018223
    Abstract: A biofuel pellet and an apparatus for making the pellet are provided. The biofuel pellet includes a first region of high density and a second region of low density. The higher density region burns more slowly than the low density region and helps to suspend the pellet for longer and more complete combustion.
    Type: Grant
    Filed: November 23, 2021
    Date of Patent: June 25, 2024
    Inventor: David W. Presby
  • Hydraulic fluid
    Patent number: 12018224
    Abstract: The present invention provides a hydraulic fluid comprising: (a) 40 to 150 ppm by weight in terms of nitrogen content of a corrosion inhibiting agent which is one or more compounds of formula (I): and/or tribologically acceptable salts thereof, wherein in formula (I): each R1 is independently a hydrocarbyl group comprising 1 to 10 carbon atoms, x is 0 to 4, and R2 is hydrogen or a hydrocarbyl group containing 1 to 10 carbon atoms; (b) 1500 to 4000 ppm by weight of an ashless nitrogen-containing dispersant; and (c) a major amount of a base oil.
    Type: Grant
    Filed: July 28, 2021
    Date of Patent: June 25, 2024
    Assignee: AFTON CHEMICAL CORPORATION
    Inventors: Helen Dyer, Madeleine Partridge
  • Succinimide dispersants post-treated with heteroaromatic glycidyl ethers that exhibit good soot handling performance
    Patent number: 12018225
    Abstract: A dispersant composition is described. The composition includes a succinimide dispersant composition comprising a reaction product of a hydrocarbyl succinimide and a heteroaromatic glycidyl ether having a structure: wherein R1 is a heteroaryl or heteroarylalkyl group having 4 to 20 carbon atoms, and R2 and R3 are independently a hydrogen atom, an alkyl group, or an aryl group.
    Type: Grant
    Filed: July 22, 2021
    Date of Patent: June 25, 2024
    Assignee: CHEVRON ORONITE COMPANY LLC
    Inventors: Priyank N. Shah, Morgan L. Miller
  • Perfuming compositions
    Patent number: 12018226
    Abstract: The present disclosure provides fragrance compositions having an olfactive profile that changes with time. The fragrance compositions include at least two contrasting perfume accords. The at least two contrasting perfume accords provide an olfactory modulating effect, such that the fragrance compositions deliver a desirable scent with increased perceived intensity and improved longevity of perception.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: June 25, 2024
    Assignee: FIRMENICH SA
    Inventors: Nicholas O'Leary, Addi Fadel, Jeffrey Dundale, Robert Knab
  • Encapsulated fragrance composition
    Patent number: 12018227
    Abstract: The present disclosure is directed to an encapsulated fragrance composition including an accord including at least one of menthol and isopulegol. Consumer products containing said encapsulated fragrance composition are also disclosed herein.
    Type: Grant
    Filed: April 21, 2021
    Date of Patent: June 25, 2024
    Assignee: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Stuart Fraser, Johan Poncelet, Tiphaine Ribaut, Jonathan Warr
  • Alkoxybenzaldehyde derivatives and precursors thereof
    Patent number: 12018228
    Abstract: The present invention refers to alkoxybenzaldehyde derivatives and precursors thereof. The invention further refers to perfume compositions and fragranced article comprising them.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: June 25, 2024
    Assignee: Givaudan SA
    Inventors: Nicolas Cocito Armanino, Corinne Baumgartner, Felix Flachsmann
  • Organic compounds
    Patent number: 12018229
    Abstract: The present invention refers to dihydropyran derivatives, and to a process of making the same. The invention further refers to perfume compositions and fragranced articles comprising them.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: June 25, 2024
    Assignee: Givaudan SA
    Inventor: Marc Liniger
  • Surfactant composition
    Patent number: 12018230
    Abstract: The present invention is a surfactant composition containing (a) a branched alkyl sulfosuccinate ester having a branched alkyl group with 9 or 10 carbons and (b) a surfactant [excluding (a)].
    Type: Grant
    Filed: March 16, 2021
    Date of Patent: June 25, 2024
    Assignee: KAO CORPORATION
    Inventors: Keita Aono, Satoru Okamura
  • Soap bar composition for high water structuring and binding
    Patent number: 12018231
    Abstract: A soap bar is provided, comprising: a soap; water; a cellulose derivative selected from the group consisting of a hydroxyalkyl alkyl cellulose; and an additive selected from the group consisting of a psyllium, a sodium silicate and mixtures thereof; wherein the soap bar is a solid.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: June 25, 2024
    Assignees: Dow Global Technologies LLC, Dow Silicones Corporation
    Inventors: Saugata Nad, Padmadas Nair, Deepak Dandekar, Sangeeta Sanjeev Patel, Amit Kumar Verma
  • Multilayer dissolvable solid article containing solid particles for making the same
    Patent number: 12018232
    Abstract: A dissolvable solid article which can include multiple layers of flexible, dissolvable, porous sheets, in which a coating composition including solid particles is present on at least one internal surface of at least one sheet and a process for making such solid articles.
    Type: Grant
    Filed: September 23, 2021
    Date of Patent: June 25, 2024
    Assignee: The Procter & Gamble Company
    Inventors: Carl David MacNamara, HongSing Tan, Robert Wayne Glenn, Jr., Wenhu Pang, Kejing Du, Yuxiang Liu
  • Wet wipes with a combination of glycines for improved preservative properties
    Patent number: 12018233
    Abstract: A cleaning composition including a preservative formulation having a glycine, a diol and a phospholipid complex is disclosed. The cleaning composition can be loaded on a cleaning wipe and used for personal care. The glycine and diol provide a preservative booster to the preservative system for the cleaning composition containing a phospholipid complex, such as cocamidopropyl PG-dimonium chloride phosphate, which has some limited independent preservation activity, depending on the level in the final formulation.
    Type: Grant
    Filed: June 1, 2021
    Date of Patent: June 25, 2024
    Assignee: Rockline Industries, Inc.
    Inventors: Ravi Chandarana, Douglas B. Cole
  • Liquid laundry detergent with cleaning booster
    Patent number: 12018234
    Abstract: A liquid laundry detergent formulation is provided, comprising: a liquid carrier; a cleaning surfactant; and a cleaning booster polymer, wherein the cleaning booster polymer has structural units of a monoethylenically unsaturated carboxylic acid monomer; structural units of an ethylenically unsaturated monomer of formula (I) and, optionally, structural units of an ethylenically unsaturated monomer of formula (II) wherein x is an average of 0 to 20; wherein y is an average of 0 to 30; wherein x+y>1; wherein R1 is a —C1-4 alkyl group; and wherein R2 is selected from hydrogen and a methyl group.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: June 25, 2024
    Assignees: Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Asghar A. Peera, Stephen J. Donovan, Roy Roberts
  • Mannanase variants and polynucleotides encoding same
    Patent number: 12018235
    Abstract: The present invention relates to mannanase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: June 25, 2024
    Assignee: Novozymes A/S
    Inventors: Vivek Srivastava, Markus Klinger, Rakhi Saikia, Vijaya Shankar Nataraj, Sohel Dalal, Jens Erik Nielsen
  • Detergent composition
    Patent number: 12018236
    Abstract: The present invention concerns a detergent and a pharmaceutical composition comprising a deoxyribonuclease (DNase), wherein the DNase is obtained from a fungal source. It further concerns a laundering method and the use of DNase. The present invention further relates to polypeptides having DNase activity, nucleotides encoding the polypeptide, as well as methods of producing the polypeptides.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: June 25, 2024
    Assignee: Novozymes A/S
    Inventors: Klaus Gori, Marie Allesen-Holm, Lilian Eva Tang Baltsen, Allan Noergaard, Jan Lehmbeck
  • Alpha-amylase variants and polynucleotides encoding same
    Patent number: 12018237
    Abstract: The present invention relates to alpha-amylase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.
    Type: Grant
    Filed: May 17, 2022
    Date of Patent: June 25, 2024
    Assignee: Novozymes A/S
    Inventors: Carsten Andersen, Vivek Srivastava, Padmavathi Balumuri, Partha Pratim Chakrabarti, Sohel Dalal
  • Beverages composed of fruit and/or vegetable components and methods for producing the same
    Patent number: 12018238
    Abstract: Described herein are beverages composed of components derived from fruits and/or vegetables by way of percolation and/or maceration with alcoholic beverages. The inventive beverages include additional additives such as one or more sweeteners, glycerol, sugar alcohols, herbs, spices, vitamins, antioxidants, flavoring agents, acids, or any combination thereof. The methods described herein maximize the isolation of bioactive nutrients present in fruits and vegetables and form unique complexes with chemosensory flavor elements. Also disclosed herein are fruit and vegetable composites by way of percolation and/or maceration of the fruit or vegetable with alcoholic beverages, wherein the composites can be used to supplement a beverage.
    Type: Grant
    Filed: October 14, 2013
    Date of Patent: June 25, 2024
    Inventor: Susanne Gardner
  • Laser processing machine
    Patent number: 12018239
    Abstract: A laser processing machine for killing specific cells from a group of cells on a surface of a layer containing an ingredient capable of absorbing laser light, the laser processing machine being configured to: control a laser light source to output laser light at 5W or less and at a wavelength of 380 nm or greater such that the laser light source is applied to a second area on a second surface of the layer opposed to the first surface; and control an actuator to provide a relative movement between the second area where the laser light is applied and the layer at a rate of 2000 mm/sec or less such that the irradiated second area absorbs energy to generate heat that kills unwanted cells on a first area of the first surface and the laser light does not instantly kill the specific cells on the first area upon irradiation.
    Type: Grant
    Filed: November 24, 2020
    Date of Patent: June 25, 2024
    Assignees: KATAOKA CORPORATION, NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Masami Suzuki, Norio Nishi, Junichi Matsumoto, Kimio Sumaru, Toshiyuki Kanamori
  • High-throughput microfluidic chip having parallelized constrictions for perturbing cell membranes
    Patent number: 12018240
    Abstract: A microfluidic chip for causing the delivery of a payload to a cell comprises a plurality of constrictions configured to allow a cell suspension to flow through one or more of the plurality of constrictions from a first fluid flow region to a second fluid flow region within the microfluidic chip, wherein a cross-sectional width of each of the plurality of constrictions is less than a diameter of cells in the cell suspension, such that membranes of the cells are perturbed when passing through the constrictions such that a payload is able to pass through the perturbed cell membranes, and wherein a quotient of a cross-sectional area over a cross-sectional perimeter of each of the plurality of constrictions is greater than greater than or equal to 0.5 ?m.
    Type: Grant
    Filed: December 27, 2021
    Date of Patent: June 25, 2024
    Assignee: STEMCELL TECHNOLOGIES CANADA INC.
    Inventors: Maisam Dadgar, Jacquelyn L. Sikora Hanson, Armon R. Sharei
  • Microbiota trapping device, microbiota trapping apparatus, and microbiota trapping method
    Patent number: 12018241
    Abstract: Provided is a technique for easily trapping microbiota in a sample. A microbiota trapping device of the present disclosure includes a first solution tank having a first filter adapted to trap residue in a sample, and a second solution tank having a second filter adapted to trap bacteria in the sample. The second solution tank has a vent above the second filter.
    Type: Grant
    Filed: September 8, 2020
    Date of Patent: June 25, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventor: Takahide Yokoi
  • Bioreactors for root organ cultures
    Patent number: 12018242
    Abstract: The present invention relates to bioreactors for root organ cultures that enable large parts of the inoculation or biomass transfer, cultivation and harvest of the cultures to be performed outside of an aseptic environment. The present invention further relates to methods of producing and aseptically harvesting roots, and methods of producing root cultures using the aforementioned bioreactors alone or as part of an apparatus further comprising an inoculation vessel or at least one further bioreactor.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: June 25, 2024
    Assignee: Evologic Technologies GmbH
    Inventors: Markus Brillmann, Paul Krautwaschl, Wieland Reichelt, Christoph Herwig
  • Fat fragmentation device and method
    Patent number: 12018243
    Abstract: The present invention provides a device for adipose tissue processing, microfragmentation and facilitation of mechanical separation of adipose derived stem cells (“ADSCs”), methods of using the device to generate a stromal vascular fraction (“SVF”) and methods of the SVF.
    Type: Grant
    Filed: November 3, 2020
    Date of Patent: June 25, 2024
    Assignee: The Duke Limited
    Inventor: Marcos Sforza
  • Adipose tissue centrifuge and method of use
    Patent number: 12018244
    Abstract: A centrifuge device is provided for the sizing and separation of constituents of a biologic mixture, e.g., adipose tissue. The device provides for the mechanical breaking down of the fibrous structure in the tissue by centrifugation causing the tissue to pass through a mesh element, or a sizing helix, or an extrusion element, whereupon the material is reduced to a slurry. This processed material may then be separated by centrifugation into its constituents, in order to harvest the fraction containing the multipotent cells. These multipotent cells may be utilized for various medical procedures to stimulate healing and tissue regeneration.
    Type: Grant
    Filed: January 9, 2023
    Date of Patent: June 25, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: John E. Nash, William T. Fisher, Gino Bradica
  • Yeast having improvement of lactic acid tolerance and use thereof
    Patent number: 12018245
    Abstract: The present invention discloses a genetically engineered Kluyveromyces sp. yeast cell comprising at least a genetic modification that inactivates or deletes a nucleotide sequence encoding for transcription factor SEQ ID No. 2, particularly Haa1. The genetically engineered yeast cell according to this invention has an improvement of lactic acid tolerance, lactic acid production or a combination thereof as compared to the parental.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: June 25, 2024
    Assignee: PTT Global Chemical Public Company Limited
    Inventors: Phatthanon Prasitchoke, Natthawut Poomsila, Kraileark Kittisuriyanont, Narong Kaewsuwan, Wikanda Techanan
  • Methods and kits for nucleic acid purification and other procedures
    Patent number: 12018247
    Abstract: A method of binding a nucleic acid and/or a contaminant from a sample includes the step of contacting the nucleic acid and/or the contaminant with a metal-based gel. The metal-based gel is preferably an aluminum-based gel, a cesium-based gel, a lanthanum-based gel, or a combination thereof. The phosphate concentration, phosphate:metal ratio, and/or pH in the sample is modulated during binding to influence the binding capacity and/or preference of the gel.
    Type: Grant
    Filed: October 12, 2020
    Date of Patent: June 25, 2024
    Assignee: LuminUltra Technologies Ltd.
    Inventors: Neil Sharma, Wei Huang
  • Sample processing devices, systems and methods
    Patent number: 12018248
    Abstract: This instant disclosure provides methods of processing a sample in an automated sample processing device including devices configured for the automated extraction or isolation of nucleic acids. Also provided are plungers for use in such devices and methods of sample processing. Systems for performing the described methods and employing the described plungers are also provided.
    Type: Grant
    Filed: January 4, 2021
    Date of Patent: June 25, 2024
    Assignee: Abbott Molecular Inc.
    Inventors: Mark Talmer, Jody L. Keck, Wesley W. Addison
  • Compositions and methods for evading bacterial defense mechanisms
    Patent number: 12018250
    Abstract: The present invention features modified polynucleotide sequences that mimic host cell DNA and methods of using such sequences for the genetic engineering of bacteria that are otherwise genetically intractable.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: June 25, 2024
    Assignee: FRED HUTCHINSON CANCER CENTER
    Inventor: Christopher D. Johnston
  • Method for synthesis of polynucleotides using a diverse library of oligonucleotides
    Patent number: 12018251
    Abstract: A method for synthesizing a target double stranded (ds) polynucleotide byproviding an oligonucleotide library within an array device that has a diversity of oligonucleotide library members, each of which has a different nucleotide sequence and is contained in a separate library containment in an aqueous solution. The library includes single stranded oligonucleotides and double stranded oligonucleotides with at least one overhang and covers at least 10,000 pairs of matching oligonucleotides. In a first step, at least a first pair of matching oligonucleotides are transferred transferred from the library into a first reaction containment using a liquid handler and the matching oligonucleotides are assembled, thereby obtaining a first reaction product comprising at least one overhang.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: June 25, 2024
    Assignee: Ribbon Biolabs GmbH
    Inventors: Harold Paul Vladar, Rodrigo Aparecido Fernandes Redondo
  • Methods and compositions for identifying neoantigens for use in treating cancer
    Patent number: 12018252
    Abstract: Provided herein, are methods of identifying neoantigens for treating and preventing cancer. Also disclosed are methods and compositions for administering identified neoantigens for the treatment and prevention of cancer.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: June 25, 2024
    Assignee: Arizona Board of Regents on Behalf of Arizona State University
    Inventors: Stephen Albert Johnston, Luhui Shen
  • Method of detecting Polycomb Repressive Complex activity
    Patent number: 12018253
    Abstract: A method of detecting Polycomb Repressive Complex (PRC) activity in a cell providing a cell with a DNA having a protein binding site and at least one reporter gene expression site is operatively connected to the protein binding site, and with a DNA containing a recombinant gene of a binding protein, the binding protein being capable of binding to the protein binding site, wherein the binding protein is fused to a member of the PRC, the method including the step of expressing the recombinant gene, letting the fused binding protein bind to the protein binding site and detecting at least one reporter gene expression.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: June 25, 2024
    Assignee: IMBA—INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH
    Inventors: Oliver Bell, Hagar Moussa, Ramesh Yelagandula
  • Methods of making unbiased phage libraries
    Patent number: 12018254
    Abstract: Described herein is a method of preparing an unbiased library of phage variants, comprising (a) preparing a population of “acceptor phage”; (b) removing an endogenous target gene and inserting gene variants into the acceptor phage genomes; (c) enriching the recombined phages; and (d) expressing the library for selection. The acceptor phage is a lytic phage comprising a synthetic genome wherein the target gene of interest is flanked by recombinase sites. The acceptor phage infects a first host bacteria expressing a recombination plasmid facilitating recombination. The phages then infect a second host bacteria expressing a counterselection system that accumulates recombined phage variants and selecting against non-recombined phages. The accumulated phage variants infect a third host bacteria. The phage library may then be sequenced and characterized.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: June 25, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Srivatsan Raman, Phil Huss
  • Compositions and methods for treating disorders of genomic imprinting
    Patent number: 12018255
    Abstract: Disclosed herein are compositions, kits, and methods for treating a disorder of genomic imprinting in a subject. The method may include modifying a zinc-finger protein 274 (ZNF274) binding site on maternal chromosome 15 at position 15q11-q13 of the subject, such that the binding of a ZNF274 protein to the ZNF274 binding site is reduced relative to a control. The ZNF274 binding site comprises a polynucleotide having at least 90% sequence identify to SEQ ID NO: 1 or SEQ ID NO: 42. Further provided are DNA targeting systems that bind to a ZNF274 binding site or to a gene encoding a ZNF274 protein.
    Type: Grant
    Filed: December 7, 2018
    Date of Patent: June 25, 2024
    Assignee: University of Connecticut
    Inventors: Stormy Chamberlain, Justin Cotney, Maéva Langouët, Marc Lalande
  • Method for modifying genes
    Patent number: 12018256
    Abstract: The present invention relates to method of modulating the level of expression of an endogenous gene in a cell, the method comprising inserting a heterologous microRNA (miRNA) response element (MRE) into the 3?-untranslated region (3?-UTR) of the gene. The binding of endogenous miRNAs to the MRE results in or leads to a repression of the level of expression of the gene. The invention also relates to cells and transgenic animals whose endogenous genes comprise heterologous MRE in their 3?-UTRs.
    Type: Grant
    Filed: July 13, 2017
    Date of Patent: June 25, 2024
    Assignee: Oxford University Innovation Limited
    Inventors: Tudor A. Fulga, Yale S. Michaels, Thomas A. Milne
  • Single-stranded RNA-editing oligonucleotides
    Patent number: 12018257
    Abstract: The invention relates to antisense oligonucleotides that are capable of bringing about specific editing of a target nucleotide (adenosine) in a target RNA in a eukaryotic cell, wherein said oligonucleotide does not, in itself, form an intramolecular hairpin or stem-loop structure, and wherein said oligonucleotide comprises a cytidine (a non-complementary nucleotide) or a uridine in a position opposite to the target adenosine to be edited in the target RNA region.
    Type: Grant
    Filed: April 6, 2023
    Date of Patent: June 25, 2024
    Assignee: ProQR Therapeutics II B.V.
    Inventors: Janne Juha Turunen, Petra Geziena De Bruijn, Bart Klein, Roxana Simona Redis, Lenka Van Sint Fiet