Abstract: The present invention is directed to a composition comprising a polymer comprising a first hyaluronic acid (HA) chain and a second HA chain crosslinked via a linker comprising an unsaturated moiety or a derivative thereof coupled to a tetrazine moiety or a derivative thereof, wherein a weight ratio between water soluble HA (sHA) and the polymer within the composition is less than 10%. In some embodiments, the polymer of the invention is characterized by having a crosslinking degree of 0.6 to 4%.

Abstract: Grafting materials are disclosed that are fabricated from citrate-based materials. The grafting materials have particular applicability in forming a biodegradable scaffold and generally include a composition that includes (i) a citrate component, (ii) a polyol, and (iii) particulate inorganic material. The polyol may take the form of a diol, e.g., butanediol, hexanediol, octanediol, or polyethylene glycol. The scaffold may take the form of a crosslinked polymer network, may be biodegradable, and may be 50-90% porous. The scaffold may be conformable and may be adapted to be cut in an operating room.

Abstract: Methods for the manufacture of porous biopolymer scaffolds containing a first biopolymer in combination with chondroitin sulfate and/or hyaluronic acid, compositions made by such methods, and use of the biopolymer scaffolds in dermal regeneration. Non-limiting examples of first biopolymers include alginate, chitosan, collagen, cellulose, gelatin, starch, and various combinations thereof.

Abstract: The present disclosure relates to a hyaluronic acid cross-linked product and a filler composition including the same, and more specifically, to a hyaluronic acid cross-linked product with high cohesion and adhesion and reduced swelling, and a filler composition including the same.

Abstract: A problem to be solved by the present invention is to provide a fibrosis inhibitor that solves the problem of inhibiting fibrosis of an organ or tissue surface, and especially of inhibiting fibrosis of an epicardial surface. Furthermore, by inhibiting fibrosis, the present invention prevents or reduces subsequent development of adhesions to avoid organ or tissue damage during re-operation. Provided is a fibrosis inhibitor for inhibiting fibrosis of a tissue by fixing a biocompatible polymer to a tissue where it is desirable to inhibit fibrosis.

Abstract: A composite ultra-thin coating film with hypersensitivity inflammatory reaction inhibition and antibacterial activity, an implant comprising the same, and a method for preparing the same are described. The composite ultra-thin coating film can be applied to medical silicone-based polymers and exhibits excellent antibacterial activity and inhibits deformed cell proliferation so that hypertrophic tissue is not formed and there is no cytotoxicity.

Abstract: A graft injector assembly includes a coating disposed on an interior surface of an injector body to form a lumen. The lumen is structured to store a graft comprising corneal tissue and to allow the graft to exit distally from the injector body, preferably with minimal or no damage to the corneal tissue. The corneal tissue may include a Descemet membrane and endothelial cells, which may be used in Descemet Membrane Endothelial Keratoplasty (DMEK). In one example, the assembly includes an organosilane coating disposed on a glass injector body.

Abstract: This patent application belongs to the field of tissue engineering. In particular, it refers to a method of producing decellularized biomaterial from biological tissue, as well as to the decellularized biomaterial produced by said method comprising biological extracellular matrix. Particularly, said biological tissue derives from animal or human ocular connective tissue. More particularly, it refers to a method of producing decellularized biomaterial from animal sclera for producing a biological scaffold, prosthesis and/or carrier of active substances, as well as biomaterial itself and uses thereof as scaffolds, prosthesis or carriers of substances for systemic or localized release.

Abstract: A photocurable composite hydrogel matrix precursor, a preparation method thereof and a scaffold with same. The photocurable composite hydrogel matrix precursor includes gelatin methacrylate, sodium alginate, sodium carboxymethyl cellulose and chondroitin sulfate, where the mass ratio of a photoinitiator to the gelatin methacrylate to the sodium alginate to the sodium carboxymethyl cellulose to the chondroitin sulfate is (0.2-0.3):(8-10):(1-3):(0.6-0.8):(0.05-0.07).

Abstract: The present disclosure provides engineered nerve grafts, methods of making engineered nerve grafts, and methods of using an engineered nerve graft to repair a nerve. Engineered nerve grafts of the present disclosure may include a body extending from a first end to a second end, the body being formed of a biocompatible hydrogel, and a plurality of microchannels extending continuously through the body from the first end to the second end, wherein each of the plurality of microchannels may have an effective diameter of about 1 micrometer to about 200 micrometers.

Abstract: A double network hydrogel consists of a first network and a second network, where the first network is, or includes, a first polymer that is formed, at least in part, of —CH2—CH(OH)— units, and the second network is, or includes, a second polymer that is formed, at least in part, of carboxyl (COOH)-containing units or salts thereof, sulfonyl (SO3H)-containing units or salts thereof, and at least one of hydroxyl (OH)-containing units or amino (NH2)-containing units, where the hydrogel may be used as a cartilage replacement.

Abstract: Systems, devices, and methods for generating fiber constructs via electrospinning are disclosed herein. The system for generating fiber constructs includes an ejection device and a collector. The collector contains a collection surface with patterns formed by conductive trace(s). The conductive trace(s) is arranged such that the resulting electric field lines are either undisturbed electrostatic field lines or blurred electrostatic field lines aligned around each conductive trace. Methods of generating fiber constructs using the system via electrospinning includes applying an electrostatic charge to the ejection device or a component thereof. The formed fiber construct has a grammage that is at least 5% higher than a grammage of a fiber construct formed on an un-patterned collector under the same conditions. The electrospun fiber constructs may be used for forming engineered tissues or implants, wound dressings, drug delivery formulations, and implant or device coatings.

Abstract: In view of the problems of inadequate adhesiveness, low operability, and inadequate convenience and portability of current tissue sealing materials, the present disclosure provides a PEG bicomponent self-adhesive absorbable biological patch, comprising a substrate layer and an adhesive coating located on the substrate layer, wherein the substrate layer is a biological material, and the adhesive coating is a hydrogel formed by a bicomponent of polyethylene glycol succinimidyl ester and polyethylene glycol amine at a specific ratio. The biological patch can be adhered firmly to the tissue surface and applied directly without extra preparation, and has good biocompatibility, has biodegradability, and can be used in common clinical scenarios such as tissue adherence, wound hemostasis, and low-pressure leakage of body fluids.

Abstract: Disclosed are a patch comprising a metal-organic framework, in particular a silicone patch comprising a metal-organic framework and a silicone composition, and an artificial skin comprising a metal-organic framework. The patch and artificial skin according to one aspect of the present invention have wound healing properties such as a reduction in the size of a scar area when attached to a scar on the skin, and in particular have an excellent wound healing effect that reduces the scar area by about 50% compared to a control group to which a patch or artificial skin not containing a metal-organic framework is attached, such that the present invention can be used as a patch for cell regeneration or skin would healing, in particular as a silicone patch, and furthermore, can be used as artificial skin.

Abstract: A multi-layer device is provided that is useful in tissue regeneration, for example, for vascular regeneration, e.g., for use in treatment of a coronary vascular disease, such as for treatment of myocardial infarction. A method of making the device also is provided.

Abstract: A prosthetic heart valve that is at least partially coated with an enhancement layer, and a method for inserting the prosthetic heart valve in a patient. The prosthetic heart valve includes an expandable frame, a leaflet structure, and optionally an inner skirt and/or an outer skirt. One or more of the components of the prosthetic heart valve can be partially or fully coated with the enhancement layer. One type of enhancement layer that can be used includes titanium oxynitride or titanium nitride oxide (TiNOx) and/or zirconium oxynitride (ZrNxOy).

Abstract: The present disclosure provides a drug delivery composition and a method of controlling a drug delivery rate of an analyte sensor. The drug delivery composition includes a copolymer including a plurality of copolymer chains, where each of the plurality of copolymer chains comprises a backbone including a plurality of hydrophilic units and a plurality of hydrophobic units, a crosslinker, and a therapeutic agent, where the crosslinker crosslinks at least a portion of the hydrophilic units of respective copolymer chains to form charges, and the hydrophobic units of the copolymer interact with the therapeutic agent through the non-polar intermolecular interaction. The drug delivery composition continuously releases the therapeutic agent at a set or predetermined drug delivery rate for a set or predetermined period of time.

Abstract: A centrifuge includes a yoke driven at a rotational speed with respect to a stationary frame of the centrifuge by a drive shaft extending from a motor. A timing belt engages a stationary sun gear and a planet gear, with rotation of the yoke rotating the timing belt and the planet gear. A shaft is associated with the planet gear, with rotation of the planet gear causing the shaft and an associated first sheave to rotate within and with respect to the yoke. Another timing belt engages the first sheave, with rotation of the first sheave causing the second timing belt and a second sheave to rotate with respect to the yoke. A receptacle rotates with the second sheave to cause a fluid separation chamber to rotate with respect to the stationary frame at a speed that is double the rotational speed at which the drive shaft is driven.

Abstract: An in-bra wearable breast pump is provided. The breast pump includes an air pump system for generating a base level vacuum and a pumping vacuum, a breast shield for receiving a user's breast and having a first side and a second side, a first channel for drawing the base level vacuum on the first side of the breast shield, and a second channel for drawing the pumping vacuum on the second side of the breast shield.

Abstract: The disclosure relates to preparing an extracorporeal blood treatment apparatus. In an example, a disposable arrangement for use in the extracorporeal blood treatment apparatus includes at least one fluid-conducting device that is configurable to define a flow circuit that extends through a blood chamber of a dialyzer. The at least one fluid-conducting device comprises connectors for connection to a vascular system of a subject during a blood treatment. The disposable arrangement also includes a sterilizing filter. The disposable arrangement is configurable to define the flow circuit to form a closed loop that includes the sterilizing filter for priming the at least one fluid-conducting device.

Abstract: A system for treatment of a fluid for a medical device. The system includes a pump coupled with an inlet tube, the pump configured to receive a fluid from the inlet tube and pump the fluid. The system includes a purification device coupled with the pump configured to treat the fluid, and a reservoir configured to house fluid in the reservoir at a first pressure. The system includes a reservoir gauge, the reservoir gauge configured to determine a pressure of the fluid in the reservoir, and an outlet tube coupled with the reservoir configured to facilitate a first flow of fluid from the reservoir. Further, the system includes a relief valve coupled with the reservoir configured to control a second flow of fluid from the reservoir, where responsive to a change in the first pressure, the relief valve is configured to modify the second flow of fluid from the reservoir.

Abstract: Systems and methods are described for adapting dialysis solution bags between different modalities of dialysis treatment. Specifically, for example, the system described herein enables an automated peritoneal dialysis (APD) patient to use APD bags from their existing stock for a manual exchange treatment, such as a continuous ambulatory peritoneal dialysis (CAPD) treatment, thereby providing that the APD patient no longer needs to retain manual exchange bags and sets in the event of an emergency or other situation requiring the performing of manual dialysis exchanges.

Abstract: A portable hemopurification system can remove one or more uremic toxins from blood of a patient. The hemopurification system includes a dialyzer with a dialyzing membrane. Blood from a patient is provided to the dialyzer on one side of the dialyzing membrane, and a negative-pressure pump applies negative pressure on the opposite side of the dialyzing membrane to provide ultrafiltration of uremic toxins from the blood. The system includes a replacement fluid line to deliver replacement fluid to the blood. The system includes load cells to measure the replacement fluid flow, effluent flow, and returned blood flow. The systems uses the fluid weights for the control of pumps to provide stable flow through the system.

Abstract: The present disclosure relates to a medical functional device or arrangement of components having a first blood circuit for extracorporally withdrawing and reintroducing blood from and to a patient (P), and a second blood circuit for extracorporally withdrawing and reintroducing blood from and to a person (D), wherein both the first blood circuit and the second blood circuit each comprise an arterial line and a venous line. In this, the medical functional device, or the arrangement, comprises at least one connecting device for establishing a fluid communication between the arterial line of the first blood circuit for the patient (P) with the venous line (73) of the second blood circuit for the person (D) and for establishing a fluid communication between the arterial line of the second blood circuit for the person (D) with the venous line of the first blood circuit for the patient (P).

Abstract: Systems and methods are provided to recover residual biological fluid from a soft sided fluid filter having an inlet and an outlet and which is used by a biological fluid processing system, including a reusable hardware unit comprising a fluid filter compression assembly. The fluid filter compression assembly further includes a housing having an outer wall that defines a housing space that receives the fluid filter, at least one bladder positioned within the housing space, at least one conduit, at least one pump, wherein the at least one conduit is in fluid communication with the at least one bladder and the at least one pump, and at least one clamp configured to selectively stop flow through the fluid filter inlet.

Abstract: Systems, devices, and methods for gas removal from a wearable device are provided. The systems comprise a gas removal filter having an inlet, a fluid outlet, and a vent port. The gas removal filter comprises a filter mesh between the inlet and outlet, the filter mesh configured to allow only liquid phase material through the filter mesh. The systems also comprises a gas detector for detecting gas in the gas removal filter; an orientation sensor for determining an orientation of the gas removal filter; a transducer protector filter having a first side and a second side, the transducer protector filter on fluid communication with the vent port of the gas removal filter; pressure transducer in fluid communication with the second side of the transducer protector filter; and an gas removal pump in fluid communication with the second side of the transducer protector filter.

Abstract: An extracorporeal circuit support with a main liquid pump, the inlet of which can be connected to the blood circuit of a patient via at least one first liquid line and the outlet of which can be connected to the blood circuit via at least one second liquid line, an oxygenator for enriching the blood being conducted in the at least one second liquid line with oxygen, and a pump drive which drives the main liquid pump. The extracorporeal circuit support has, in addition to the main blood pump or main liquid pump and the oxygenator, the pump drive designed to be MR-conditional, i.e., MR-compliant under specific conditions, and is designed in the form of a gas expansion motor.

Abstract: A catheter system can include a tubular body, and at least one of a targeting system coupled to the tubular body, an expandable member, or a fluid injection port. A method of identifying a bifurcation can include inserting a catheter system into a first vessel, positioning the catheter system at a first location, expanding an expandable member to occlude the first vessel, delivering contrast material so the contrast material pooling proximate to the expandable member, and reviewing a shape of the contrast material in the first vessel under fluoroscopy.

Abstract: A medical waste fluid collection cart may include a container assembly and a suction tube having a lumen extending through the suction tube. The suction tube may communicate with the container to deposit waste fluid from a surgical site in the container. The container assembly may include a container, a base forming a bottom of the container, and a lid assembly. The base may include an interior surface defining a draining opening. The interior surface may extend along a ramped path toward the drain opening. The lid assembly may include a lid ring and a lid capable of engaging each other with a twist lock mechanism. The lid ring may engage the container and the lid may cover at least part of a central opening to the container. The container may have a window and a tinting assembly. The container assembly may have a vacuum level detection system.

Abstract: A closure container that can house a preset drug applicator in an easily accessible manner with tamper evidencing means. The closure container contains a plurality of dosing ribs and a retainer to retain the syringe in a preset dosage amount and preferably has a window to view the barrel of the syringe.

Abstract: A syringe stabilizing apparatus has a base and a syringe support. The syringe support is vertically disposed above the base, elevating a fluid-filled portion of an infusion set vertically above the base and orienting a delivery end of the fluid-filled portion upwardly relative to a horizontal plane to take advantage of a gravitational effect on a fluid during delivery of the fluid from the fluid-filled portion to a patient. The syringe support comprises a first retainer and a selectively actuated tube clamp. The first retainer has an opening in which a rigid portion of the infusion set is received and retained therein without further user intervention. The selectively actuated tube clamp is operatively aligned with the first retainer wherein a flexible tube extending from the rigid portion of the infusion set extends through the tube clamp.

Abstract: Example systems, methods, and apparatus are disclosed herein for on-screen parameter programming guidance based on user-inputted data and patient history graphical display generation based on a user-inputted command. The example systems, methods, and apparatus are configured to use a preloaded drug library to determine the upper and lower limits of parameters, and display a color graph and differently-colored text on a PCA pump user interface screen accordingly. Additionally, the example systems, methods, and apparatus are configured to use real-time patient history data to generate and display a patient history graph on a user interface screen. The disclosed systems, methods, and apparatus prevent human programming errors by minimizing the need for extensive user interaction with PCA pumps and the need to toggle between programming screens. Further, the disclosed systems, methods, and apparatus prevent human programming errors by displaying patient history in a single, consolidated graph.

Abstract: An inserter assembly may comprise a casing having an open end and a closed end. The inserter assembly may further comprise a first unit at least partially within the casing movable relative to the casing. The first unit may comprise a device base. The first unit may further comprise a sharp. The first unit may further comprise a body configured to displace in tandem with the sharp at least during displacement of the sharp from a forward to a retracted state. The first unit may further comprise a bias member configured to displace the body toward the closed end and displace the sharp to the retracted state when a release latch is transitioned from an engaged to a released state. One of the casing and the body may include a projection which engenders tilting of the body as the body and sharp are displaced by the bias member.

Abstract: An inserter assembly may comprise a casing having an open end and a closed end. The inserter assembly may further comprise a first unit at least partially within the casing movable relative to the casing. The first unit may comprise a device base. The first unit may further comprise a sharp. The first unit may further comprise a body configured to displace in tandem with the sharp at least during displacement of the sharp from a forward to a retracted state. The first unit may further comprise a bias member configured to displace the body toward the closed end and displace the sharp to the retracted state when a release latch is transitioned from an engaged to a released state. One of the casing and the body may include a projection which engenders tilting of the body as the body and sharp are displaced by the bias member.

Abstract: A system for drawing a solution is provided. The system includes a filter, a vacuum source, and an actuator. The filter has an input port, a first output port, a second output port, and a flow path defined in part by the input port and the second output port. The vacuum source is in fluid communication with the first output port and operative to apply a vacuum to the flow path. The actuator is operative to facilitate movement of the solution along the flow path.

Abstract: A system for monitoring an intravenous (IV) access site for catheter insertion into a patient's skin. The system may include one or more of a dressing layer configured to cover at least a portion of the IV access site, a cuff configured to be disposed at least partially around the dressing layer, and a camera positioned external to the IV access site. At least one of the dressing layer and the cuff may include at least one embedded component configured for use in detecting one or more of swelling of the IV access site, temperature changes at the IV access site, fluid infiltration/extravasation from the catheter, fluid detection on top of the patient's skin at a skin piercing location, catheter dislodgement, color changes of the patient's skin at the IV access site, presence of microbes at the IV access site, and degradation of the dressing layer.

Abstract: The invention provides a control method of an infusion pump and an electronic device that determines identification information and/or consumable information of a target infusion consumable set to the infusion pump; determines, according to the identification information and/or consumable information, a control rule of the infusion pump corresponding to the target infusion consumable; and adjusts according to a preset correction rule, the control rule corresponding to the target infusion consumable. By adjusting the control rule of the target infusion consumable according to the preset correction rule in the invention, the control rule of each target infusion consumable set to the infusion pump can be automatically adjusted, making the manner of calibrating the infusion pump more accurate and convenient.

Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: An apparatus includes a housing, a medicament container, a needle assembly, and an insertion member. The needle assembly includes a needle coupling member and a needle. A flow passageway is defined between a first end portion and a second end portion of the needle coupling member. The needle coupling member is rotatably coupled within the housing such that it rotates between a first orientation and a second orientation such that a portion of the needle extends from the housing in the second orientation. The insertion member is movable within the housing from a first position to a second position. A contact portion of the insertion member engages the second end portion of the needle coupling member to move the needle coupling member from the first orientation to the second orientation when the insertion member moves from the first position to the second position.

Abstract: A dual chamber injection system, comprising a guiding element arranged along a longitudinal axis and configured to at least partially contain a medicament container, the guiding element defines an inner surface and at least one protrusion extending radially inwardly therefrom; a plunger rod assembly, comprising a plunger outer portion arranged along the longitudinal axis and a plunger inner portion arranged concentrically within the plunger outer portion and having at least one guiding groove arranged on an outer surface of the plunger inner portion; the plunger outer portion is disposed externally relative to the guiding element; the plunger inner portion is at least partially received into the guiding element; and wherein the plunger rod assembly is displaceable relative to the guiding element and the displacement is guided by engagement of the at least one protrusion with the at least one guiding groove.

Abstract: The present invention relates to a syringe barrel having an interior surface coated with a silicone film having a thickness in the range of 5 nm to 100 nm. It further relates to a method for manufacturing said syringe barrel comprising the step of reducing an initial thickness of a pre-formed silicone film on the interior surface of a syringe barrel to a thickness within the range of about 5 nm to about 100 nm by exposing the syringe barrel to an organic solvent or by subjecting the syringe barrel to mechanical treatment. Furthermore, the present invention relates to a syringe comprising the syringe barrel of the invention, a kit comprising said syringe, and cosmetic and therapeutic uses of said syringe.

Abstract: A syringe including a hollow cylindrical body containing a product to be injected and from which there extend a hollow tip equipped with a Luer-lock connector and a plunger, sliding inside the hollow cylindrical body; and a tamper-proof cap including a closure cap and a tamper-proof insert, where the closure cap includes a portion for coupling with the Luer-lock connector and a handle portion. An external seat for housing the tamper-proof insert is formed in the handle portion of the main body of the closure cap. The tamper-proof insert includes at least one longitudinal section, a transverse section and a terminal element, which is connected to a free end of the longitudinal section by a frangible connection, the terminal element configured to be immovably housed in a corresponding groove formed on an external surface of the Luer-lock connector. The tamper-proof insert is immovably coupled to the closure cap.

Abstract: The present disclosure relates to a housing of a drug delivery device, the housing comprising first and second housing components with first and second connecting ends, and: an insert provided on one of the first connecting end and the second connecting end, a receptacle provided on the other one of the first connecting end and the second connecting end, a fastening element provided on the insert and comprising a snap element, a counter fastening element provided in the receptacle and comprising a counter snap element to engage with the snap element, a mechanical coding provided on the insert and comprising a coding feature, a mechanical counter coding provided in the receptacle, wherein at least one of the fastening element, the counter fastening element, the mechanical coding and the mechanical counter coding comprises a groove.

Abstract: An autoinjector includes a case adapted to hold a medicament container having a needle, a needle shroud telescopically coupled to the case, and a plunger rotationally and slidably disposed in the case. The needle shroud is movable between a first extended position relative to the case in which the needle is covered and a retracted position relative to the case in which the needle is exposed. The plunger is rotatable relative to the case between a first rotational position in which the plunger is engaged to the case and a second rotational position in which the plunger disengages the case. The needle shroud is operably coupled to the plunger. When the needle shroud translates from the first extended position to the retracted position, the plunger rotates from the first rotational position to the second rotational position.

Abstract: A mixing syringe, including: a barrel; a hollow plunger disposed inside the barrel, the hollow plunger having a stopper disposed on a distal end thereof and an open proximal end; a flexible container disposed inside the hollow plunger, the container containing a first material; a metering rod adapted to be inserted in the open proximal end of the hollow plunger so as to enclose the container therein, the metering rod adapted to be advanced within the hollow plunger from the open proximal end to the distal end thereof in predetermined increments.

Abstract: An autoinjector includes a case, a syringe carrier slidably disposed within the case and adapted to hold a syringe including a stopper, a plunger slidably disposed within the syringe carrier and adapted to apply a force on the stopper, and a drive spring disposed within the plunger and biasing the plunger relative to the syringe carrier.

Abstract: The present invention relates to a portable device for injecting a substance, comprising a supply circuit comprising a chamber having a first end with an outlet orifice and an open second end, a piston extending towards the inside of the chamber from the second end, the chamber having a volume that can be varied by the movement of the piston, a first electric motor (12) for moving the piston, the outlet orifice of the chamber being connected to a retractable injection needle (11) so as to supply this needle with the contents of the chamber.

Abstract: The invention discloses a method and a device for producing a medicine particle flow, belonging to medical health care instruments. The device is characterized by comprising a water mist production device equipped with an ultrasonic atomization device and a fan, and a first closed channel equipped with a heating device, wherein a water mist guide outlet of the water mist production device is connected with a water mist inlet of the first closed channel. Compared with the prior art, the method and the device of the invention have the advantage that effective components of Chinese herbal medicines without volatility can reach the skin together with steam in the form of fine particles, or even molecules, so as to be conveniently absorbed by the skin.

Abstract: A vaporization and inhalation apparatus comprising a cartridge container configured to receive a cartridge including a liquid. The apparatus includes a heating element configured to heat the liquid to a point of vaporization to generate a vaporized form of the liquid. The apparatus also includes an outlet port through which the vaporized form of the liquid is inhaled.

Abstract: An active smoke filtration unit is used to remove smoke during laparoscopic surgery. The active smoke filtration unit is part of a recirculation circuit. The recirculation circuit is pneumatically isolated from a primary flow generator, such as an insufflator, by a valve assembly. The active smoke filtration unit can be housed separately from the valve assembly or together with the valve assembly. The recirculation circuit can include a humidifier to beat and humidify the insufflation gases.