Patents Issued in September 12, 2024
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Publication number: 20240299258Abstract: The present invention provides a dental curable composition and a dental prosthesis therewith with which shade changes in the base material can be reduced, and that exhibit excellent gloss retention in the cured product while demonstrating excellence in operability. The present invention relates to a dental curable composition comprising a polymerizable compound (A), a polyfunctional thiol (B) having two or more mercapto groups per molecule, a polysiloxane (C), and a polymerization initiator (D).Type: ApplicationFiled: June 28, 2022Publication date: September 12, 2024Applicant: Kuraray Noritake Dental Inc.Inventors: Hiroyuki SAKAMOTO, Nobusuke KASHIKI, Miki YOSHIDA, Akira NOZAKI, Chihiro HARA
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Publication number: 20240299259Abstract: [Problem] Providing a whitened capsule and a whitened film without using any white pigment such as titanium dioxide. [Solution] Provided is a film, a capsule, and a film forming composition, characterized by comprising: a film-forming polymer; and a whitening agent including either a surfactant or both a surfactant and a salt, and characterized in that the surfactant is selected from a fatty acid ester of polyhydric alcohol, a polyethylene glycol, a polypropylene glycol, a polyalkylene oxide derivative, an alkyl sulfate ester salt, and a saponin.Type: ApplicationFiled: May 17, 2024Publication date: September 12, 2024Applicant: Capsugel Belgium NVInventors: Kaori Sato, Takahisa Takubo, Hitomi Doi
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Publication number: 20240299260Abstract: The present invention relates to a solid cosmetic composition for caring for and/or making up keratin materials, in particular the skin, in the form of a compact powder comprising, in a physiologically acceptable medium: a solid phase comprising at least fillers and pigments treated with an additive of formula (I) [Chem 1], it being possible to obtain said composition by means of a process comprising the following steps: (i) mixing a liquid phase comprising at least water and the solid phase in powder form, so as to form a paste; and (ii) shaping the paste by compacting and total or partial removal of the liquid phase so as to obtain the composition in the form of a compact powder.Type: ApplicationFiled: September 21, 2021Publication date: September 12, 2024Inventors: Murielle Farigoule, Valérie Bouchard De La Poterie
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Publication number: 20240299261Abstract: The present invention relates to a method for treating freshly bleached hair, a composition and use thereof.Type: ApplicationFiled: December 13, 2023Publication date: September 12, 2024Applicant: WELLA GERMANY GMBHInventors: Manfred SCHMITT, Petra BRAUN, Rebecca KNOBLOCH
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Publication number: 20240299262Abstract: The present disclosure provides an antiperspirant composition that includes active component and an inactive component. The antiperspirant composition can be present as a stick antiperspirant, a body spray, a clear gel, or an aerosol antiperspirant. The active component can include an aluminum salt, a magnesium salt, a film former, an extract solution, or a mixture thereof. The extract solution can include nymphaca coerulea flower extract and Nelumbo nucifera flower extract.Type: ApplicationFiled: March 10, 2022Publication date: September 12, 2024Inventors: Danielle Lima Lorenzetti, Jose Elvecio dos Santos Teixeira, Diego Takeshi Higa Araki
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Publication number: 20240299263Abstract: The present invention relates to a carbonate-hydroxyapatite functionalized with a germicide, chosen among chlorhexidine and its salts, benzalkonium halides, diisobutyl phenoxyethoxyethyl dimethyl benzyl ammonium halides, alkyl dimethyl ethylbenzyl ammonium halides, cetylpyridinium halides and mixtures thereof. The present invention also relates to cosmetic compositions, such as oral care compositions or skin-care compositions, comprising said functionalized carbonate-hydroxyapatite.Type: ApplicationFiled: May 4, 2022Publication date: September 12, 2024Applicant: KALICHEM S.R.L.Inventors: Gianbattista RASTRELLI, Francesco RASTRELLI
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Publication number: 20240299264Abstract: A method for the prevention, reduction and treatment of gingivitis, white spots in an oral cavity on teeth and attributable to caries, cavities, and/or combinations thereof, oral cavities, caries, or a combination thereof in a subject in need thereof is provided. The method may include administering a medicament comprising hops beta acid, and a metal. The metal may comprise tin, zinc, or combinations thereof. The medicament is an oral care composition that is substantially free of fluoride.Type: ApplicationFiled: May 6, 2024Publication date: September 12, 2024Inventors: Arif Ali Baig, Tammy K. Baker, Aaron Reed Biesbrock, Samuel James St. John
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ETHER COMPOUNDS AS VOLATILES FOR THE TREATMENT OF AMINO ACID BASED SUBSTRATES, SUCH AS SKIN AND HAIR
Publication number: 20240299265Abstract: The present invention relates to a compound for use in cosmetic compositions of the formula (I): R1—O—R2, wherein R1 and R are different from each other and are independently selected from the group of C1-C17 hydrocarbyl residues, said hydrocarbyl residues contain up to 8 CH3 groups and up to 3 ether groups (—O—), and wherein the total number of carbon atoms of said compounds is 10 to 20, the total number of ether groups of said compounds is 1 to 6, and the total number of methyl groups (—CH3) of said compounds CN is 1 to 13, at least one of R1 and R2 is a branched C3-C17 hydrocarbyl residue, in particular, as so-called volatiles in skin care and hair care compositions, as well as cosmetic compositions comprising at least one of said ether compounds, and the use of the aforementioned ether compounds in cosmetic compositions.Type: ApplicationFiled: January 12, 2022Publication date: September 12, 2024Inventors: Roland WAGNER, Christian WENSKE, Felix NEUMEYER, Justine TAXACHER, Katharina STREICHER, Thorsten FELDER, Mathiselvam MANOHARAN, Amar PAWAR, Benjamin FALK, Janet DUFFY, Kalyanachakravarthi KOTHAPALLI -
Publication number: 20240299266Abstract: Described herein is a method of using a composition including a fragrance component, where the fragrance component is present in an amount of from about 0.1% to 96% relative to the total weight of the composition where the fragrance component comprises one or more perfume ingredients selected from a specific list. The method includes using the composition as a skin moisturizer.Type: ApplicationFiled: November 1, 2022Publication date: September 12, 2024Inventors: Vera TCHAKALOVA, Laura MESMIN
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Publication number: 20240299267Abstract: The present invention relates to a fragranced composition comprising: a) at least one compound of formula (I), or a geometrical isomer thereof, an organic or mineral acid or base salt thereof, or a solvate thereof, in particular hydrates: b) at least one dyestuff; and c) at least one fragrancing substance.Type: ApplicationFiled: December 28, 2021Publication date: September 12, 2024Inventor: Christophe BOBIN
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Publication number: 20240299268Abstract: It relates to an anhydrous composition for caring for keratin materials comprising: a) at least one cosmetic active ingredient sensitive to water and/or oxygen; b) at least one non-ionic surfactant selected from polyglyceryl fatty acid esters with a HLB value not less than 13 at the temperature of 25° C. and ethoxylated/propoxylated fatty alcohols; and c) dipropylene glycol; wherein the composition does not comprise any cationic surfactant. It also relates to a non-therapeutic process for caring for keratin materials, comprising mixing the anhydrous composition and water or a hydrous system to form a microemulsion and applying the microemulsion to the keratin materials.Type: ApplicationFiled: March 30, 2021Publication date: September 12, 2024Applicant: L'OREALInventors: Di WU, Lingling SUN
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Publication number: 20240299269Abstract: A personal care composition comprising from 2% to 10% of an anionic surfactant; from 0.5% to 5% of a hydroxy acid selected from the group consisting of salicylic acid in combination with citric acid; wherein the personal cleansing composition has a pH of about 2.5 to about 5.5.Type: ApplicationFiled: March 8, 2024Publication date: September 12, 2024Inventors: Brennan Alexander SCHILLING, Eric Scott JOHNSON, Sreejata MUNSI, Susan Adair GRIFFITHS-BROPHY
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Publication number: 20240299270Abstract: Personal care compositions and, for instance, skin care peels are described herein. In accordance with certain aspects, provided is a personal care composition comprising a retinoid, a beta hydroxy acid and/or a salt thereof; and a meroterpene; optionally wherein the personal care composition is substantially free, or free, of resorcinol and/or hydroquinone.Type: ApplicationFiled: March 8, 2024Publication date: September 12, 2024Applicant: Colgate-Palmolive CompanyInventors: Savitha Rajagopal, Ewelina Lesniak, Melissa Moy
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Publication number: 20240299271Abstract: A transparent cleanser including: (A) an ester oil; (B) an aliphatic hydrocarbon having 8 or more and 20 or less carbon atoms; and (C) a nonionic surfactant, in which a content of the ester oil (A) is 40% by mass or more and 90% by mass or less to a total amount, the nonionic surfactant (C) includes: (C1) a polyglyceryl difatty acid ester consisting of a fatty acid having 8 or more and 10 or less carbon atoms and a polyglyceryl having an average polymerization degree of 4 or more and 10 or less; and (C2) a polyglyceryl difatty acid ester consisting of a fatty acid having 18 or more and 22 or less carbon atoms and a polyglyceryl having an average polymerization degree of 8 or more and 15 or less, and a mass ratio of the components (C1) and (C2) is from 2.5:1 to 10:1.Type: ApplicationFiled: June 14, 2022Publication date: September 12, 2024Applicant: SHISEIDO COPMAPY, LTD.Inventors: Yuki WATANABE, Hiromi TANAKA, Yukiko HIRUMA
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Publication number: 20240299272Abstract: A personal care composition that includes an acyl taurate surfactant and exhibits improved foaming and lathering in hard water. The surfactant system in the personal care composition also includes an N-alkyl acyl taurate surfactant and/or an amphoteric co-surfactant. The weight ratio of acyl taurate to N-alkyl acyl taurate and/or co-surfactant is tailored to provide the desired hard water lather benefit. The surfactant system also permits viscosity building with inorganic salt and demonstrates good lather and foaming when a cationic conditioning polymer is added.Type: ApplicationFiled: March 8, 2024Publication date: September 12, 2024Inventors: Debora W. Chang, Brandon Scott Lane, Maria Eugenia Gomez, Joshua Mikell Williams
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Publication number: 20240299273Abstract: The present invention generally relates to the technical field of multiphasic liquid compositions comprising an active ingredient, and in particular, to multiphasic liquid compositions demonstrating improved deposition of an active ingredient. In certain embodiments, the compositions can be used as personal care compositions or household care compositions.Type: ApplicationFiled: February 8, 2022Publication date: September 12, 2024Inventors: Chloe MOREAU, Margot BON, Anne-France LERON, Martin VETHAMUTHU, Denis BENDEJACQ, Ahmed ALSAYED
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Publication number: 20240299274Abstract: The invention is directed to a hydratable concentrated surfactant composition. The composition is pourable, easy to dilute, substantially free of sulfate and oil, comprises a C6-C14 acid, alcohol, amide or mixture thereof, anionic surfactant and an amphoteric surfactant, zwitterionic surfactant or both. The composition is in lamellar phase and thickens and transforms to an isotropic phase upon dilution. The composition comprises a mono-, di and/or tri-ester, can be used as a concentrate in small volumes and diluted as used and needed or can be diluted with water in refill packaging to ensure a reduction in plastic waste.Type: ApplicationFiled: June 30, 2022Publication date: September 12, 2024Applicant: Conopco, Inc., d/b/a UNILEVERInventors: Douglas John HIBAN, Teanoosh MOADDEL, Tirucherai Varahan VASUDEVAN, Thomas Alan KWAN
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Publication number: 20240299275Abstract: A personal care composition comprising from about 2% to about 10% of an anionic surfactant wherein the anionic surfactant is selected from: wherein R1 is a saturated or unsaturated alkyl chain with 7 to 23 C atoms, R2 is H or an alkyl group with 1 to 4 carbon atoms, R3 is H, COO-M+, CH2COO?M or COOH, n is 0 to 2, X is SO3?, and M is a suitable counterion selected from H, sodium, potassium, magnesium, triethanolamine or ammonium; from 0.5% to 5% of a hydroxy acid wherein the hydroxy acid is salicylic acid in combination with citric acid; wherein the personal care composition has a pH of about 2.5 to about 5.5 and wherein the composition is substantially free of sulfate based surfactant.Type: ApplicationFiled: March 8, 2024Publication date: September 12, 2024Inventors: Brennan Alexander SCHILLING, Eric Scott JOHNSON, Debora W. CHANG, Sreejata MUNSI, Susan Adair GRIFFITHS-BROPHY
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Publication number: 20240299276Abstract: The invention encompasses compositions and methods for treating skin and preventing disorders of the skin. In various embodiments, compositions of the invention enhance cell turn over, moisture balance, decrease modalities of inflammation, bacterial adhesion, and oxidation of sebum in a hydrogel polymer carrier system for comedogenic and acnegenic prevention especially to pre-adolescents.Type: ApplicationFiled: May 19, 2022Publication date: September 12, 2024Inventors: Cynthia KUPER, Konstantinos LAHANAS
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Publication number: 20240299277Abstract: The present invention relates to a skin care composition comprising: cedrol; and at least one selected from the group consisting of beta-sitosterol and linoleic acid; or ferulic acid; and at least one selected from the group consisting of beta-sitosterol and linoleic acid. More specifically, the present invention relates to a cosmetic, a food, and a quasi-drug composition comprising the composition as an active ingredient: improvement of skin whitening, antioxidant, skin elasticity or skin wrinkles, or skin moisturizing. In addition, the composition of the present invention compensates for the low formulation stability of cedrol and ferulic acid and it was found that the effects of antioxidant, melanin reduction, collagen synthesis promotion, and hyaluronic acid synthesis promoter were all synergistically exhibited when cedrol or ferulic acid is used in combination with at least one selected from the group consisting of beta-sitosterol and linoleic acid, compared to when cedrol or ferulic acid is used alone.Type: ApplicationFiled: December 22, 2021Publication date: September 12, 2024Applicant: LG HOUSEHOLD & HEALTH CARE LTD.Inventors: Gwang Jin LEE, So Young LEE, Mu Hyun JIN, Seo Rim MIN, Young Bong KIM
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Publication number: 20240299278Abstract: The present invention relates to a cosmeceutical composition, comprising, relative to the total weight of said composition: collagen, in an amount between 620 wt ‰ and 760 wt ‰; saline solution, in an amount between 225 wt ‰ and 350 wt ‰; hyaluronic acid or a pharmaceutically acceptable salt thereof, in an amount between 1 wt ‰ and 3 wt ‰; and at least one natural anti-inflammatory and anti-oxidant agent.Type: ApplicationFiled: March 6, 2023Publication date: September 12, 2024Inventors: Federica LAZZERINI, Fabio CLEMENTI
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Publication number: 20240299279Abstract: The present invention relates to a cosmetic composition comprising: at least 30% by weight of water with respect to the total composition weight, at least 5% by weight of ascorbic acid with respect to the total composition weight, at least one cationic polymer chosen from cationic galactomannan gums and cationic cellulose polymers modified by groups including at least one linear fatty chain, said composition having a pH between 5 and 7, preferably between 5.5 and 6.5. It also relates to a cosmetic product for the care of keratin materials using this composition.Type: ApplicationFiled: June 28, 2022Publication date: September 12, 2024Applicant: L'OREALInventors: Naima YOUSFI, Muriel ISOIR-INGREZ, Anne FALIP, Laurence SEBILLOTTE-ARNAUD
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Publication number: 20240299280Abstract: Example embodiments are directed to new sunscreen compositions with high SPF, including (a) a combination of at least one anionic surfactant and one non-ionic co-surfactant, (b) UV filters and (c) pigments. The composition is stable over the time, also presents a high level of UV-protection in order to protect the skin from the damages of the sun, easy application, good spreadability, less white film, less shine, which does not melt on high temperature in the face, has an imperceptible touch and combines high protection with smoothness to the skin.Type: ApplicationFiled: March 9, 2023Publication date: September 12, 2024Inventors: Patricia TRAJANO, Angeles FONOLLA-MORENO, Renata Souto Maior Afonso FERREIRA, Tassia HANASHIRO, Ludmila Pons CAMARGO, Jose Mario Melo BARCELOS
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Publication number: 20240299281Abstract: A shampoo formulation is provided, comprising: dermatologically acceptable vehicle; dermatologically acceptable silicone; a dermatologically acceptable hair cleaning surfactant; a deposition aid polymer, wherein the deposition aid polymer is a modified carbohydrate polymer, comprising a dextran base polymer functionalized with (i) quaternary ammonium groups of formula (II) bound to a pendent oxygen on the dextran base polymer (II) wherein is a pendent oxygen on the dextran base polymer, wherein X is a divalent linking group; wherein each R2 is independently selected from a C1-4 alkyl group; and wherein R3 is a linear or branched C1-16 alkyl group; and (ii) hydrophobic substituents of formula (III) bound to a pendent oxygen on the dextran base polymer (III) wherein is a pendent oxygen on the dextran base polymer; wherein Z is a divalent linking group; wherein a is 0 or 1; and wherein each R5 is a linear or branched C6-22 alkyl group.Type: ApplicationFiled: May 12, 2022Publication date: September 12, 2024Inventors: Lyndsay M. Leal, Lu Bai, Emmett M. Partain, III, Daniel S. Miller, Junsi Gu, Meng Jing
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Publication number: 20240299282Abstract: Disclosed herein are compositions comprising complexes of cyclodextrins and lipid-modified stem cell proteins. Also disclosed are topical compositions the complexes. Methods of using the compositions for the therapeutic purposes are also disclosed as well as methods of producing the compositions.Type: ApplicationFiled: April 26, 2023Publication date: September 12, 2024Inventor: Gabriel NISTOR
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Publication number: 20240299283Abstract: The present invention relates to a process for colouring hair keratin fibers comprising the application of a composition A and a composition B to hair keratin fibers, in which: composition A comprises at least one (poly)carbodiimide compound, and composition B comprises: —at least one associative polymer; and—at least one compound, different from the associative polymers, containing at least one carboxylic acid group; composition A and/or composition B comprising at least one colouring agent chosen from pigments, direct dyes and mixtures thereof; and in which composition A and composition B are applied simultaneously or sequentially to the hair keratin fibers. The present invention also relates to a device for colouring hair keratin fibers.Type: ApplicationFiled: March 10, 2022Publication date: September 12, 2024Applicant: L'OrealInventor: Chrystel Pourille
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Publication number: 20240299284Abstract: The present invention relates to a process for removing colour from hair keratin fibers, comprising the application of at least one colour-removing composition to hair keratin fibers which have been coloured beforehand using at least one hair colouring composition comprising: at least one (poly)carbodiimide compound; and at least one colouring agent chosen from pigments, direct dyes and mixtures thereof; said colour-removing composition comprising: at least one glycol ether; and optionally at least one alkyl or alkylene carbonate.Type: ApplicationFiled: March 10, 2022Publication date: September 12, 2024Applicant: L'OrealInventors: Lindsay Menzer, Alexis Liard, Charlotte Delostal, Victtoria Djaidi
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Publication number: 20240299285Abstract: An aqueous, sulfate-free personal care composition that provides good cleaning, foaming, lathering, viscosity and stability. The composition includes an acyl taurate surfactant and an N-alkyl acyl taurate surfactant at a weight ratio of acyl taurate to N-alkyl acyl taurate of 1:4 to 50:1. The composition also includes a co-surfactant and water. The N-alkyl acyl taurate surfactant and co-surfactant are specifically tailored to solubilize the acyl taurate surfactant in the composition and thereby deliver the desired composition benefits.Type: ApplicationFiled: March 8, 2024Publication date: September 12, 2024Inventors: Debora W. Chang, Joshua Mikell Williams
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Publication number: 20240299286Abstract: The inventive cosmetic includes; (A) organosiloxane represented by the following formula (1), and having a boiling point in a range of 205 to 255° C. and a kinematic viscosity at 25° C. of less than 5 mm2/s; and (B) volatile oil having a kinematic viscosity at 25° C. of 2 mm2/s or less, excluding the component (A). wherein, R each independently may be identical to or different from one another and represents a group selected from the group consisting of a hydrogen group, a hydroxy group, and a monovalent hydrocarbon group having 1 to 3 carbon atoms. “a” is an integer from 1 to 5. It is provided that at least one of R is a monovalent hydrocarbon group having 2 or 3 carbon atoms. This cosmetic can provide a light feeling, good spreadability and a uniform cosmetic film, and exhibit excellent stability over time and excellent cosmetic durability.Type: ApplicationFiled: March 5, 2024Publication date: September 12, 2024Applicant: SHIN-ETSU CHEMICAL CO., LTD.Inventor: Akiko MIZUNO
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Publication number: 20240299287Abstract: The present invention relates to a cosmetic composition for care and/or make-up of keratinous materials, in particular the lips, comprising, in a physiologically acceptable medium: a) a silicone/polyurethane polymer with an active material content of at least 17.5% by weight relative to the total weight of the composition, b) one or more linear or branched C8-C19 alkanes, c) a silica powder, preferably a processed hydrophobic powder, and d) optionally pigments.Type: ApplicationFiled: December 23, 2021Publication date: September 12, 2024Inventors: Elodie Champredonde, Valérie Bouchard De La Poterie
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Publication number: 20240299288Abstract: The present invention relates to an active ingredient comprising oligo-glucans, obtained from the cytosolic fraction of a yeast of the species Saccharomyces cerevisiae, a cosmetic composition comprising said active ingredient and cosmetic uses thereof, in particular to improve the regeneration of the skin and combat aging thereof.Type: ApplicationFiled: August 1, 2022Publication date: September 12, 2024Inventor: Jean PAUFIQUE
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Publication number: 20240299289Abstract: A method of preventing progression of an appearance or effect of aging in a subject is provided. A method of preventing, limiting, or inhibiting injury to skin integrity in a subject is also provided. A method of substantially maintaining a state of skin integrity in a subject is further provided. A method of preventing a topographical change of a cutaneous layer of skin in a subject is still further provided. The methods comprise administering an effective amount of a preparation comprising ammonia oxidizing microorganisms to the subject. Related preparations and kits are also provided.Type: ApplicationFiled: May 13, 2024Publication date: September 12, 2024Inventors: Todd Krueger, Lauren Nicole Ambrogio
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Publication number: 20240299290Abstract: Compositions for intranasal delivery of benzodiazepines and methods for their use to treat and prevent seizures are provided. The compositions deliver rapid therapeutic onset with a decreased incidence and/or severity of adverse effects after administration. Additionally, use of the compositions for the treatment of seizure clusters increases the time to a second seizure and duration of the interseizure cluster interval.Type: ApplicationFiled: January 5, 2024Publication date: September 12, 2024Applicant: Neurelis, Inc.Inventors: Enrique J. CARRAZANA, Adrian L. RABINOWICZ, Sunita MISRA
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Publication number: 20240299291Abstract: An ophthalmic preparation is effective for preventing and treating dry macular degeneration and retinal light damage. The preparation includes an active ingredient for treating an ocular disease and an ophthalmic preparation carrier or adjuvant. The active ingredient for treating the ocular disease is an adenylate-activated protein kinase activator and/or an anti-inflammatory active ingredient. The ophthalmic preparation carrier or adjuvant contains the following components: a surfactant, an ionic macromolecule, and a solvent. The ophthalmic preparation can be administered by eye drops for carrying (wrapping) the adenylate-activated protein kinase activator and/or the anti-inflammatory active ingredient through the anterior eye segment, and delivering same to a posterior eye segment for preventing and treating dry macular degeneration and retinal light damage.Type: ApplicationFiled: November 29, 2021Publication date: September 12, 2024Inventors: Qing DONG, Lubing XUE
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Publication number: 20240299292Abstract: A semi-solid chewable gel composition, comprising a gelling composition in a sufficient amount to provide a cohesive gelled product, a binding composition comprising a sugar, a sugar alcohol, or a combination thereof, wherein the sugar comprises psicose (allulose), sorbose, tagatose, D-maltose (1,4-diglucose), trehalose, isomaltulose, or a combination thereof, and a water-soluble polymer stabilizer, wherein the polymer stabilizer comprises a polymer of monosaccharide monomers selected from glucose, mannose, galactose, arabinose, rhamnose, xylose, galacturonate, glucuronate, N-acetylglucosamine, or a combination thereof, and wherein the polymer comprises from about 5 to about 500 monosaccharide monomers, wherein the semi-solid chewable gel composition is substantially free of glucose, sucrose, and fructose.Type: ApplicationFiled: December 1, 2021Publication date: September 12, 2024Applicant: Seattle Gummy CompanyInventors: Feng WAN, William Brenden Carlson
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Publication number: 20240299293Abstract: Compositions and methods are provided for a nasal spray or mouthwash formulation for prevention and amelioration of disease progression caused by a virus infection, the formulation including: an algae derivative; and a buffer. The method effectively bathes the mouth and throat tissues to decrease COVID-19 concentration and functionality; thereby preventing growth and spread of the virus and lower the viral load present in the lungs and in GI tract.Type: ApplicationFiled: November 9, 2021Publication date: September 12, 2024Inventor: Keith D. Crawford
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Publication number: 20240299294Abstract: A method for delivering a medication for treatment of a pulmonary disease depending on location(s) of infection lesion(s) within a respiratory tract of a patient is disclosed. The method includes administering metered doses of the medication to the patient having the pulmonary disease by a metered dose inhaler (MDI) actuator having a function of controlling drug particle delivery characteristics. The medication is effective for treating the pulmonary disease. A therapeutically effective amount of medication for treating the pulmonary disease is administered by various metered doses of the medication. The medication includes an active pharmaceutical ingredient (API) associated with treatment of a pulmonary disease. The medication includes a propellant, a co-solvent, and a surfactant. The API is dissolved in the propellant at a pre-determined ratio, with or without a co-solvent. The medication is administered via metered-dose inhalation.Type: ApplicationFiled: February 28, 2023Publication date: September 12, 2024Inventors: Jack Yongfeng ZHANG, Mary Zi-ping LUO, Ying WANG, Yi XIA, Jie Fei DING, Selina SU, Qingxia HAN
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Publication number: 20240299295Abstract: Aqueous formulations containing active pharmaceutical ingredient and cyclodextrin and their method of preparation and their uses are provided hereinType: ApplicationFiled: September 9, 2022Publication date: September 12, 2024Inventors: Thotsaphon VONGASAVARIT, Aruna PERERA, Kevin David HOWE
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Publication number: 20240299296Abstract: There is provided an applicator head (10) for administration of a topical formulation, comprising a dosing aid for application of a predefined dose of the topical formulation. The applicator head (10) comprises an applicator surface (20) adapted to apply the topical formulation to a user's skin. The applicator surface (20) comprises an outlet opening (40). The dosing aid comprises a dose marking, or dose markings (60, 60?, 60?, 62?, 62?) on the applicator surface (20), and wherein the dose marking (60, 60?, 60?, 62?, 62?) circumscribes an inner dosing compartment (64) that serves to measure the predefined dose of the topical formulation, and wherein the outlet opening (40) is disposed inside the inner dosing compartment.Type: ApplicationFiled: February 22, 2022Publication date: September 12, 2024Inventors: Amit SABHERWAL, Sylvain Patrice Dominique FRADIN
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Publication number: 20240299297Abstract: In one aspect, the disclosure provides a stable emulsion that comprises a hydrophobic phase and a hydrophilic phase. In another aspect, the disclosure provides a stable emulsion, comprising a hydrophobic phase and a hydrophilic phase, for electrostatic spray drying. In still another aspect, the disclosure provides a stable, water-dispersible particulate. In yet another aspect, the disclosure provides a method for making a stable emulsion. In a further aspect, the disclosure provides a method for making a stable, water-dispersible particulate. In a still-further aspect, the disclosure provides for compositions comprising an emulsion of this disclosure and particulate.Type: ApplicationFiled: January 27, 2022Publication date: September 12, 2024Inventors: John Nicholas Jackowetz, Soheil Hajirahimkhan
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Publication number: 20240299298Abstract: The present application discloses compositions comprising nanoparticles of vitamin K2, and their methods of use.Type: ApplicationFiled: February 26, 2024Publication date: September 12, 2024Applicant: Epizon, Inc.Inventors: Sam L. Nguyen, John M. Rudey
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Publication number: 20240299299Abstract: This invention relates generally to compositions and methods for increasing the efficacy of immunotherapies and vaccines. In particular, the present invention relates to compositions comprising one or more metabolites (derivatives, prodrugs, or pharmaceutical salts thereof), and related methods of increasing the efficacy of immunotherapies and vaccines through administration of such compositions.Type: ApplicationFiled: June 22, 2022Publication date: September 12, 2024Inventors: James J. MOON, Kai HAN, Deepak NAGRATH, Kim HUTCHINGS, Martin CLASBY
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Publication number: 20240299300Abstract: The present invention relates to liposome vitamin C preparations which enhance absorption of vitamin C into cells and prolong the retention of liposome vitamin C within the blood plasma and tissue of mammals, such as humans. The liposome vitamin C preparations of the present invention include amphipathic and amphiphilic molecules which improve the absorption of liposome vitamin C resulting in higher plasma and cellular levels.Type: ApplicationFiled: March 4, 2024Publication date: September 12, 2024Inventor: Pedro P Perez
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Publication number: 20240299301Abstract: The present invention relates to lipid nanoparticles and a method for preparing same and, more specifically, to particles containing an ionizable lipid and a polyethylene glycol moiety (PEG moiety)-degradable liking functional group-lipid conjugate, which are characterized by minimized side effects in vivo and effective nanoparticle transfer into target cells so as to deliver pharmaceutically effective materials into the cytoplasm.Type: ApplicationFiled: June 23, 2022Publication date: September 12, 2024Inventors: Taewoo LEE, Yu Mi BAEK, Jiwon RYU, Dahye JANG
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Publication number: 20240299302Abstract: Disclosed are cell membrane-derived nanovesicles, a method of preparing the nanovesicles, and a pharmaceutical composition and a diagnostic kit using the nanovesicles. The cell membrane-derived nanovesicles may prevent potential adverse effects because intracellular materials (e.g., genetic materials and cytosolic proteins) unnecessary for delivering therapeutic or diagnostic substances are removed from the nanovesicles. In addition, as the nanovesicles may be targeted to specific cells or tissues, therapeutic or diagnostic substances may be predominantly delivered to the targeted cells or tissues, while delivery of the substances may be inhibited. Therefore, the nanovesicles may alleviate suffering and inconvenience of patients by reducing adverse effects of therapeutic substances and by improving efficacy of the substances.Type: ApplicationFiled: May 9, 2024Publication date: September 12, 2024Inventors: Yong Song GHO, Dong-Sic CHOI, Gyeongyun GO
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Publication number: 20240299303Abstract: Provided is a nanostmcture or a microstmcture comprising a plurality of cyclic molecules, each of which is provided with an opening, and a plurality of chain-like molecules, the nanostmcture or microstructure being such that each of the plurality of chain-like molecules is included in skewered fashion in some of the plurality of cyclic molecules, whereby a plurality of pseudo-polyrotaxanes and/or polyrotaxanes are formed, wherein some or all of the adjacent cyclic molecules in the nanostmcture or microstmcture crosslink with each other.Type: ApplicationFiled: May 9, 2022Publication date: September 12, 2024Applicant: The University of TokyoInventors: Kohzo ITO, Shuntaro UENUMA, Yumi SHIKANO
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Publication number: 20240299304Abstract: A method of preparing a compact bioadhesive, gastroretentive matrix is disclosed. A homogeneous mixture of powders is first prepared which contains an alkylcellulose or an hydroxyalkylcellulose, a water-insoluble, water-swellable cross-linked polycarboxylic polymer and a pH regulator. The mixture of powders is next made into compressed units by direct compression and then heated at a temperature of between 80 and 250° C. for 1-60 minutes. The mixture of powders may also include an active substance. The compressed units thus obtained are characterized by a prolonged release and have a release kinetics of the active substance of substantially zero order in an aqueous solution at pH 1-8.Type: ApplicationFiled: March 21, 2022Publication date: September 12, 2024Applicant: UNIVERSITA DEGLI STUDI DI GENOVAInventors: Gabriele CAVIGLIOLI, Sara BALDASSARI, Guendalina ZUCCARI, Giorgia AILUNO
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Publication number: 20240299305Abstract: Extended release pyridostigmine dosage forms, suitable for maintaining stable plasma concentrations with reduced or minimized initial burst release/dose dumping of pyridostigmine, are provided. The dosage forms include matrix tablets, gastroretentive tablets, and pellets, the latter being suitable for dosing in capsules, tablets, and sachets, as well as for sprinkling on foodstuffs. The disclosure also provides methods for improving patient compliance by administering once-a-day extended release pyridostigmine bromide dosage forms that provide a superior controlled drug release.Type: ApplicationFiled: February 9, 2024Publication date: September 12, 2024Applicant: AMNEAL COMPLEX PRODUCTS RESEARCH LLCInventors: Siva Ram Kiran Vaka, Dipen Desai, Wantanee Phuapradit, Navnit H. Shah, Namdev B. Shelke
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Publication number: 20240299306Abstract: The present disclosure provides solid solution capsule formulations of Compound 1 and methods of making the same. Also provided herein are methods of treating individuals suffering from or susceptible to a disease or disorder involving pathologic activation of C5a receptors by administering an effective amount of one or more solid solution capsules comprising Compound 1. Further provided herein are singe unit dosage capsules comprising certain amounts of Compound 1, and kits comprising a solid solution capsule comprising Compound 1.Type: ApplicationFiled: February 9, 2024Publication date: September 12, 2024Inventors: Manmohan Reddy LELETI, Jay P. POWERS
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Publication number: 20240299307Abstract: The present disclosure provides extended release atomoxetine compositions suitable for once-daily administration. The compositions comprise a core comprising atomoxetine or a pharmaceutically acceptable salt thereof; and a functional coat/extended release coat over the core. The extended release compositions of the disclosure provide a lag time of at least about 30 minutes during which compositions release less than or equal to 20% of atomoxetine or the pharmaceutically acceptable salt thereof, based on the total weight of atomoxetine or a pharmaceutically acceptable salt thereof present in the composition, measured in 900 mL of a dissolution medium comprising 0.05 M pH 6.8 buffer, using USP Apparatus II (paddle) at 50 rpm and 37° C.Type: ApplicationFiled: February 15, 2022Publication date: September 12, 2024Applicant: Tulex Pharmaceuticals, Inc.Inventors: Yu-Hsing Tu, Shanmuka Harish Chalamuri, Kalyan Kathala, Ashok Perumal, James A. Lee