Abstract: A cell sheet for transplantation into a living body, containing MSCs having an average cell density of 3.0×104 cells/cm2 or less on the surface of the sheet is provided. A method for producing a cell sheet for transplantation into a living body, including: a step of seeding MSCs on a cell culture carrier having a three-dimensional structure formed of fibers at a cell number of 3.0×105 cells/cm2 or less; and a step of culturing the MSCs and thereby preparing a cell sheet containing the MSCs having an average cell density of 3.0×104 cells/cm2 or less is also provided.

Abstract: The present invention aims to provide a method for suppressing differentiation of ganglion cell, amacrine cell, horizontal cell and/or bipolar cell in a neural retina tissue containing photoreceptor precursor and/or photoreceptor, and the like. A method for suppressing differentiation of a ganglion cell, an amacrine cell, a horizontal cell and/or a bipolar cell in a neural retinal tissue containing a photoreceptor precursor and/or a photoreceptor, including a step of culturing a retinal tissue comprising a neural retinal progenitor cell and in any stage between a differentiation stage immediately after emergence of a ganglion cell and a differentiation stage where emergence rate of a cone photoreceptor precursor reaches maximum in a medium containing a thyroid gland hormone signal transduction pathway agonist.

Abstract: The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.

Abstract: The present disclosure discloses a composite tubular material and a preparation method thereof. The tubular material is prepared from extracellular matrix and directionally arranged synthetic polymer fibers through compounding; the synthetic polymer fibers serve as an internal skeleton, a fiber diameter ranges from 1 ?m to 2000 ?m, a fiber angle ranges from 0° to 180°, and a wall thickness ranges from 1 ?m to 1000 ?m; and extracellular matrix components are obtained from human or animal tissue through decellularization. According to the present disclosure, the tubular material with bioactivity and excellent mechanical properties can be prepared from the synthetic polymer and the natural material extracellular matrix through compounding; the synthetic polymer fibers with controllable fiber angle and diameter serve as the internal skeleton of the tubular material, and accordingly the tubular material has the mechanical properties of resistance to bending and squeezing.

Abstract: A volatile composition dispenser comprises a volatile composition container comprising at least one volatile composition therein. A rupture element is positioned proximate to the volatile composition container. The volatile composition container comprises a cam comprising a camming surface. The camming surface is configured to move at least a portion of the rupture element toward the volatile composition container to puncture the volatile composition container and release at least a portion of the volatile composition from the volatile composition container such that the portion of the volatile composition evaporates and exits the volatile composition dispenser.

Abstract: Systems and methods are provided for collecting a platelet product from a fluid including platelets and plasma. Platelet-rich plasma is separated from at least a portion of another constituent of the fluid and then may be further separated into concentrated platelets and platelet-poor plasma, with the concentrated platelets being resuspended. Separated platelets are conveyed through a size exclusion filter and into a platelet storage container. The size exclusion filter is configured to remove platelet clumps and/or particles larger than a platelet from the separated platelets. Subsequently, an additive is conveyed through the size exclusion filter and into the platelet storage container. Conveying additive through the size exclusion filter improves platelet recovery in the platelet product by displacement of separated platelets with the additive and may also break up any platelet clumps that are present in the size exclusion filter.

Abstract: A method for detecting occult hemorrhages is provided. The method includes obtaining a first hematocrit concentration prior to infusing a saline solution into a bloodstream of a patient. The method further includes infusing the saline solution into the bloodstream of the patient and obtaining a second hematocrit concentration after infusing the saline solution into the bloodstream. The method also includes determining a first absolute blood volume based on the first hematocrit concentration and the second hematocrit concentration. In addition, the method includes generating a notification indicating a potential occult hemorrhage based on the first absolute blood volume and a pre-defined absolute blood volume threshold, and providing the notification indicating the potential occult hemorrhage.

Abstract: The present invention relates to a dialysis machine having a dialyzer and having a first balancing chamber and having a second balancing chamber, wherein the first inflows of the first balancing chamber halves are in fluid communication with a source of fresh dialyzate and the first outflows of the first balancing chamber halves are in fluid communication with a dialyzer inflow, and wherein the second inflows of the second balancing chamber halves are in fluid communication with a dialyzer outflow and the second outflows of the second balancing chamber halves are in fluid communication with a drain, wherein a third balancing chamber is provided that has two balancing chamber halves that are separated from one another by a movable wall, wherein each of the balancing chamber halves has a respective inflow and a respective outflow that are each provided with valves that are configured to close or open the respective inflow or outflow, wherein the two inflows are in fluid communication with a source of fresh dial

Abstract: The present invention is directed to wall box for hemodialysis interface having two isolated zones. The first zone is a clean interface zone having sources of purified water and dialysis fluids. The second zone is a waste interface zone comprising waste connectors and a waste drain.

Abstract: A drainage or infusion catheter and methods of use are disclosed. In one embodiment, the catheter includes a tube body having a proximal end and a distal end, and a plurality of ports arranged along the tube body from the distal end to the proximal end. The distal end of the tube body is configured to deform around itself into a substantially spiral shape so as to cover at least one of the plurality of ports located near the proximal end of the tube body. In another embodiment, a flap is configured to erupt from apertures arranged in the tube and extend outwardly around the tube body so as to cover at least one of the plurality of ports located near the proximal end of the tube body.

Abstract: The present invention provides methods and devices for augmenting impaired glycocalyx barrier function in a subject in need thereof by contacting a sample (e.g., blood) obtained from the subject with a glycocalyx-mimetic adsorption media. The adsorption media includes glycosaminoglycan structures and, optionally, proteoglycan core proteins, which are conducive to enhancing and/or restoring the impaired glycocalyx barrier function in a sample. The contacted sample is subsequently separated from the adsorption media, producing a treated sample that can be infused into the subject. Methods and devices for treating a patient suffering from a disease associated with glycocalyx barrier dysfunction are also provided herein.

Abstract: A device, kit, and method for aspirating graft tissue and delivering the graft tissue to a target delivery site. An injector comprises a cylinder and a plunger that is both linearly and rotatably advanceable and retractable within the cylinder. A kit comprises an injector, a cartridge, and a cartridge coupling element that connects the cartridge to the injector. The kit may also include a container that is configured to retain a cartridge and to facilitate connection between the injector and the cartridge. The container includes at least one fluid barrier that prevents spillage of storage solution from the container when the injector is at least partially inserted into the well of the container.

Abstract: This disclosure relates to an improved liposuction apparatus having a handpiece. The handpiece may have a handpiece suction pathway extending through the handpiece from a front end to a back end of the handpiece and a handpiece infiltration fluid pathway extending through the handpiece from the front end to the back end of the handpiece, the handpiece suction pathway and the handpiece infiltration fluid pathway being separate and distinct. The handpiece may be configured such that, when a suction cannula having a suction cannula pathway is attached to the front end of the handpiece, the suction cannula pathway and the handpiece suction pathway are in fluid communication with one another. And, when an infiltration fluid cannula having an infiltration cannula pathway is attached to the front end of the handpiece, the infiltration cannula pathway and the handpiece infiltration fluid pathway are in fluid communication with one another.

Abstract: Some arrangements disclosed herein relate to devices and methods for treating a wound, comprising applying negative pressure to the wound through a cover applied over a wound, monitoring the internal pressure in the wound, and controlling the closure of the wound by controlling the amount that a wound packing material positioned under the cover collapses within the wound based on the monitored internal pressure. The wound packing material collapse can be controlled to ensure that the monitored internal pressure does not exceed a threshold value. Additionally, some embodiments or arrangements disclosed herein relate to a visualization element to visualize a location of a wound surface. The visualization element can comprise a radiopaque member that is configured to be positioned on or adjacent to a surface of an open wound.

Abstract: An ultrasonic electronic rhinitis therapeutic apparatus with far-infrared atomized coconut essential oil is disclosed. The apparatus includes a nasal plug part and a nasal alar part. The nasal plug part includes an insertion column disposed in a nostril. The insertion column is internally provided with a coconut powder, and a far-infrared generating tube is arranged in the coconut powder. An ultrasonic generator is arranged in the nasal alar part, and the nasal alar part is fitted on the lateral side of the nasal alar. In the disclosure, the oil and acid substance in the coconut powder are atomized by far-infrared light and are atomized under the aid of pulse ultrasonic wave in the nasal cavity to be inhaled into the internal tissues of the nasal cavity, sinus and the like.

Abstract: An indirectly heated capillary aerosol generator comprises a capillary tube adapted to form an aerosol when liquid material in the capillary tube is heated to volatilize at least some of the liquid material therein and a thermally conductive material in thermal contact with the capillary tube. The indirectly heated capillary aerosol generator provides substantially even and uniform heating across the heated length of the capillary tube.

Abstract: Aerosol-generating apparatus (100) for self-diagnosis allow users to initiate the self-diagnostics and then provide a diagnostic indication using, for example, indicators (162). The aerosol-generating apparatus (100) may include an aerosol-generating device (102) and a host device (101). The host device (101) may include one or more user-selectable switches (152) to initiate a self-diagnostic procedure and one or more indicators (162) to depict or display the diagnostic indication.

Abstract: A connection unit for air feeding tube is a connection unit to which an air feeding tube is connectable and fixable and which includes: a first pipe having an opening through which gas from the air feeding tube flows in; a second pipe that is configured to be arrangeable substantially parallel to a surface of a bed used in an examination, and includes an opening through which the gas flows out; and an air feeding flow path which is formed to include the two openings and through which the gas is fed. When the air feeding tube is fixed to the connection unit for air feeding tube and is used, a part of the air feeding flow path for the gas is formed so as to pass through an area located at a position opposite to a gravitational direction with respect to a central axis of the second pipe.

Abstract: A cartridge for an electrically operated aerosol-generating system is provided, the cartridge including: a liquid storage portion including a housing holding a liquid aerosol-forming substrate, the housing having an opening; and a fluid-permeable heater assembly including a plurality of electrically conductive filaments, the fluid-permeable heater assembly being fixed to the housing and extending across the opening of the housing. An aerosol-generating system, and a method of manufacture of a cartridge for an electrically operated aerosol-generating system, are also provided.

Abstract: A gases flow rate sensing system may be configured to operate in at least two different target temperature modes, based upon a measured temperature of the gases flow. In some embodiments, the gases flow sensing system may have a voltage divider containing a thermistor. The gases flow rate may be determined based upon a voltage output indicating an amount of power needed to maintain the thermistor at a target temperature as specified by the target temperature mode, and a measured temperature of the gases flow.

Abstract: A blower includes a housing including an inlet and an outlet, a motor to drive a rotatable shaft, first and second impellers provided to the shaft, the first and second impellers each including a plurality of impeller blades, a first stationary component provided to the housing and including stator vanes downstream of the first impeller, and a second stationary component provided to the housing and including stator vanes downstream of the second impeller. A first set of stator vanes of the first stationary component is provided around the motor and are configured and arranged to direct airflow along the motor, to de-swirl the airflow and to decelerate air to increase pressure. A blower including a third impeller and third stationary component positioned above the first impeller is also described.

Abstract: A continuous positive airway pressure (CPAP) apparatus includes: a first unit including a first housing provided with a first flow path that connects a first inlet port and a first outlet port and in which an air blower is provided; and a second unit including a second housing provided with a second flow path that connects a second inlet port and a second outlet port. The first flow path between the first inlet port and the air blower includes a first silencer. The second flow path includes a second silencer. In a first use state where the second unit is attached to the first unit, the second outlet port is connected to the first inlet port. In a second use state where the second unit is not attached to the first unit, the first inlet port is opened to the outside.

Abstract: A system, method and apparatus to automatically perform endotracheal intubation in a patient comprising, inserting a blade inside the upper airway of the patient to retract an anatomical structure; inserting a bending portion and a tube arranged on the bending portion inside the airway of the patient; collecting airway data using at least one imaging sensor arranged on the bending portion; communicating collected airway data to a processing circuitry; predicting an intended path for insertion of the tube and generating control signals using the processing circuitry, wherein the intended path is predicted based on at least one anatomical structure recognized by the processing circuitry using the collected airway data; displaying an intended path via a user interface to display at least one intended path to an operator and also allow the operator to select an intended path; and communicating the control signals generated by the processing circuitry to at least one actuation unit to actuate the three-dimensional

Abstract: A nasal ventilation mask supplies breathing gas to an airway of a patient. The mask has a housing defining an internal cavity and having a peripheral end defining an end opening. The end opening is in fluid communication with the internal cavity. The end opening is configured to be positioned over an airway on a face of the patient. A sealing member is connected to the housing proximate the end opening. The sealing member extends towards the internal cavity and is configured to abut the face of the patient and deflect towards the internal cavity. The housing further defines a connector assembly having an opening in fluid communication with the internal cavity. The connector assembly is configured to be operably connected to a supply of breathing gas.

Abstract: A seal-forming structure for a patient interface may include a patient-contacting surface configured to engage the patient's facial skin to form a seal; a posterior opening formed in the patient-contacting surface, the posterior opening configured to provide the flow of air at said therapeutic pressure to the patient's nares; and a support structure extending from the patient contacting surface to an interior surface of the seal-forming structure, the support structure and the interior surface forming a continuous loop, wherein the patient interface is configured to allow the patient to breath from ambient through their mouth in the absence of a flow of pressurised air through the plenum chamber inlet port, or the patient interface is configured to leave the patient's mouth uncovered.

Abstract: Provided are devices for engaging highly portable gas containers are provided that include a mouthpiece component comprising a flexible mouthguard, a variable inlet component that allows gas to flow from two or more sources to the user, or both. In embodiments such a device comprises engagement means for engaging gas container(s), a transition element that comprises an interior flow passage and a substantially rigid or resilient body, and optionally, a lip engagement component. The devices can be used in assemblies/devices that comprise one or more gas containers containing gas, e.g., an oxygen-rich gas and possibly other ingredients, such as nitric oxide, helium, or active pharmaceutical ingredients. In aspects, the components engage a gas container operable as a gas delivery system independently of such components. Also provided are methods of using such devices, e.g., in delivering oxygen to a person exposed to undesirable saliva-transmissible agents, e.g., harmful chemicals or infectious agents.

Abstract: The disclosure provides a ventilation apparatus. The ventilation apparatus includes a housing, an inhalation branch, a control unit, a gas source port, an exhalation branch, and a paramagnetic oxygen sensor. The paramagnetic oxygen sensor is used for detecting the oxygen content in the inhalation branch. The gas source port is disposed on the housing. The inhalation branch, the control unit, and the exhalation branch are enclosed within the housing. The paramagnetic oxygen sensor is disposed outside the housing.

Abstract: A breathing assistance apparatus user interface is described which presents animated information related to the management of the apparatus. The user interface is provided on a display screen of the apparatus. The animated illustrations can correspond to operational modes, warnings, user instructions, fault conditions, status, menu options, and the like. The animations can include a sequence of images shown in rapid succession which depict moving icons or objects, scrolling text, flashing colors, or any combination of these or the like. The user interface can combine static information along with animations.

Abstract: Systems and methods for adjusting a user's circadian rhythm are described. In some embodiments, a system may include one or more input modules for collecting data, a light source, a processor system including one or more processors that controls the light source, and a memory system storing one or more machine instructions. The system may be configured to obtain light sensitivity data for a user, compare the user's light sensitivity data against calibration data, and based on at least the light sensitivity data and the calibration data, generate instructions for activating the light source to adjust the user's circadian rhythm.

Abstract: This invention generally provides two tactile stimulation modules, or “tappers”. One tapper is held by a person in each of his hands. Alternatively, a tapper is secured to each wrist or to other parts of the body on opposite sides. Each tapper is powered by a rechargeable battery, and contains both a tactile stimulation transducer, such as an electric motor having either a balanced or unbalanced mass on its output shaft, and a transceiver that communicates with a host or master. Each tapper includes at least one control button and a status indicator. Each tapper contains a micro-controller that performs tasks such as communication, motor activation, user monitoring and control, battery monitoring, low-power sleep, and algorithm execution. At least one tapper can contain at least one optional sensor, which measures a physiological function. Measurements can be used to modify performance of the tactile stimulation transducers.

Abstract: The disclosure relates to a system of circumferentially (preferably helically) arranging indicia on the elongate body of a medical device such as a catheter. The disclosure also relates to an anchor drain for securing a surgical drain to a fluid collection device. The anchor drain resists disconnection of the surgical drain from the fluid collection device and also resists occlusion of the conduit connecting the surgical drain and the fluid collection device, even when a suture is tied about a portion of the anchor drain inserted within the surgical drain, and resists unintentional withdrawal of the surgical drain from the body or a body cavity.

Abstract: Disclosed herein are expandable introducer sheaths and methods of making and using the same. The sheaths minimize trauma to a patient's vasculature by allowing for temporary expansion of a portion of the sheath to accommodate passage of a delivery system for a cardiovascular device, then return to a non-expanded state after the passage of the device. The sheath includes an elongated annular member having longitudinally extending channels that facilitate the sheath's temporary expansion. The channels are positioned in such a way that, upon expansion, they enable the movement of protruding contact surfaces toward the inner and outer surfaces of the annular member, reducing friction between the surface and the passing device. Some embodiments of the expandable sheath include an elastic outer layer that pushes the protruding contact surfaces back towards their original positions after the passage of the device.

Abstract: An insertion device for delivering media inside a patient includes an outer guide tube having a side port. An inner guide tube is nested within the outer guide tube and movable axially within the outer guide tube. The inner guide tube includes a deflector at an end within the outer guide tube. The device also includes a catheter nested within the inner guide tube and movable axially within the inner guide tube. The deflector of the inner guide tube is positionable such that it deflects the dispensing end of the catheter outward through the opening in the outer guide tube when the catheter is advanced axially within the inner guide tube. A therapeutic delivery cannula may be nested within the catheter, such that the deflected end of the catheter determines the direction of travel of the therapeutic delivery cannula into patient tissue when the cannula emerges from the catheter.

Abstract: Tissue puncture devices, and systems and methods for accessing tissue (e.g., cardiovascular tissue) according to the present disclosure may include a tubular sheath extending along a longitudinal axis, the tubular sheath having a proximal end and a distal end, a needle disposed coaxially in the sheath, the needle having a proximal end and a distal end and being movable along the longitudinal axis of sheath, and a needle control mechanism disposed at the proximal end of the needle, the needle control mechanism being configured to lock the distal end of the needle in a first position retracted within the distal end of the sheath, and release the needle to an unlocked second position such that the distal end of the needle is extendable beyond the distal end of the sheath.

Abstract: A deflectable catheter including an outer member having a proximal portion and a distal portion, an elongated column member extending distally from the outer member and an inner member positioned coaxial with the outer member and attached to the column member. The inner member extends distally of the outer member and has a distal tip portion. A reinforcement member is positioned over the column member to restrict axial movement of the column member such that when one of the inner member or outer member is moved with respect to the other, axial compression of the column member is restricted by the reinforcement member causing the distal tip portion of the inner member to deflect laterally.

Abstract: Medical devices and methods for delivering fluid. The medical devices include one or more needles for delivering fluid. The methods may include expanding an expandable member such as an inflatable member to expand an expandable scaffold outward toward a lumen wall.

Abstract: A catheter shield is described herein. The catheter shield has a sleeve configured to receive and house a proximal end of a catheter projecting from a patient, a retention structure configured as an outer protective barrier, a first adhesive layer disposed on a bottom portion of the retention structure, wherein the first adhesive layer provides adherence to the patients skin; a second adhesive layer provided on an outer edge of the sleeve and located within a diameter of the retention structure, wherein the second adhesive layer is configured as a middle protective barrier, a third adhesive layer located within a diameter of the second adhesive, wherein the third adhesive is layer is configured as an inner protective barrier, and wherein the third adhesive layer comprises a moisture indicator posited thereon.

Abstract: A temporary low profile intraluminal catheter for infusing agents into, or extracting fluids from, a bodily lumen featuring securement structure, wherein the securement structure allows the catheter to be placed with minimal intrusion into the bodily lumen is disclosed. With such design affording a more efficient, verifiable placement of the catheter with less complication due to infection and biofilm related issues, among other types of complications.

Abstract: A needle assembly for treating tension pneumothorax includes an elongated needle disposed within an elongated catheter, and a housing for containing the needle and catheter. The needle is coupled to the housing through a length adjustment mechanism so that the needle and the catheter are configured to be deployed out of the distal end of the housing to a pre-determined length. The length adjustment mechanism may include an axial path in the wall of the housing, grooves extending off of the axial path, and a protruding arm coupled to the needle. The protruding arm of the needle is configured to extend through the axial path of the housing and be grasped by a user to deploy the needle and catheter out of the distal end of the housing. When the needle is deployed to a desired length, the user may lock the needle and catheter in place by positioning the protruding arm in the corresponding groove extending off of the axial path.

Abstract: The present technology is directed to adjustable shunting systems having a shunting element, a shape memory actuator, and a lumen extending therethrough for transporting fluid. The shape memory actuator can have a plurality of struts proximate the shunting element and a plurality of projections extending from the plurality of struts. In operation, the shape memory actuator can be used to adjust a geometry of the lumen. In some embodiments, the system is configured such that (a) any strain in the shape memory actuator is concentrated in the struts, and/or (b) the struts experience greater resistive heating than the projections when an electrical current is applied to the actuator.

Abstract: Implantable shunt devices and methods for draining cerebrospinal fluid from a patient's subarachnoid space include a shunt having opposed first and second ends, the second end being constructed to penetrate a wall of a sigmoid, transverse, straight, or sagittal sinus of the patient, a one-way valve, a hollow passageway extending between the second end and the one-way valve such that cerebrospinal fluid can be drained through the second end and out through the valve, and a mechanism coupled to the shunt and configured to anchor the shunt at a desired location proximal to the subarachnoid space.

Abstract: Drug delivery devices and methods of administering drugs to patients are provided. A device includes a reservoir containing a drug. The reservoir is defined by a wall having a water-permeable portion, such that the water-permeable portion permits water to enter the device and contact the drug. A restraining plug closes off an opening of the device such that transient microchannels form between an elastic portion of the device and the restraining plug, upon the generation of a sufficient pressure within the reservoir, to release the drug from the device. Methods of treating patients for neurogenic detrusor overactivity resulting from a spinal cord injury and/or for idiopathic overactive bladder and urinary incontinence are also provided.

Abstract: A burn/wound healing suit with circulating healing anesthetizing and antiseptic liquid. The healing suit is formed of modular parts, including a torso part, upper extremity parts, and lower extremity parts. Each modular part tapers at an end where it connects to another modular part, or seals at this end to be used individually. A connection part is a rigid tube that goes between the connecting parts to enable fluid connection between the different parts. The fluid is circulated by a pump, and heated and filtered to maintain a sterile environment.

Abstract: The present disclosure provides methods for administering formulations to the suprachoroidal space of the eye to achieve targeted drug delivery to a desired site of action within the eye. The methods include using a pushing formulation that includes a material such as a gel that expands due to physiochemical cues; or using an electric field to affect the movement of a formulation within the suprachoroidal space; or a combination of a pushing formulation with an electric field.

Abstract: An apparatus for delivering an active ingredient into skin of an animal at a defined depth, the apparatus including: a microprojection array including a plurality of microprojections having a density of at least 2,000 projections per cm2; and an applicator that drives the microprojection array towards the skin in use so that the microprojection array impacts on the skin with a mass-to-velocity ratio of between 0.0005 g/m/s and 0.1 g/m/s per cm2.

Abstract: A linear drive for pigmentation devices, comprising a stator, an air gap which is provided in the stator and is formed so as to be offset in a defined manner, an electric coil within the stator, said coil being designed to produce a concentration of the magnetic flux in the air gap as a result of the coil being energized, an armature which is designed to carry out sliding axial movements in the stator, and a permanent magnet which is captively connected to the armature.

Abstract: A humidifier adaptor for evacuating fluid and/or debris from a ventilator system includes a housing having a base, a top, and at least one sidewall, which together define a chamber and an inlet in the base of the housing extending into the chamber. The inlet includes a first end configured to receive air from a humidifier, a second end in the chamber, and a sidewall. The second end of the inlet can be positioned to at least partially inhibit the fluid and/or debris from entering an interior portion of the inlet. The humidifier adaptor also includes a tangential outlet in the at least one sidewall of the housing through which the air flows substantially tangentially out of the chamber. The humidifier adaptor also includes a drain outlet in the base of the housing for removing fluid and/or debris from the ventilator system by evacuation through the chamber.

Abstract: A needleless access connector having an access port and a sustained release antimicrobial coating only on a top surface of the access port is disclosed. The top surface of the access port can be defined by a top surface of a proximal end of a housing and a top surface of a head portion of a compressible valve disposed within an internal cavity of the housing. In certain embodiments of the present disclosure, the sustained release antimicrobial coating is on: (i) the top surface the proximal end of the housing, or (ii) the top surface of the head portion of the compressible valve, or (iii) the sustained release antimicrobial coating is only on both the top surface the proximal end of the housing and the top surface of the head portion of the compressible valve.

Abstract: Provided is an electroosmotic pump including a housing including a shaft hole, a membrane disposed between a first space arranged in a direction away from the shaft hole and a second space adjacent to the shaft hole, a first electrode body and a second electrode body arranged at opposite sides based on the membrane, a shaft extending to an outside of the housing through the shaft hole, and a first fluid included in an internal space of the housing.

Abstract: Method and system for controlling oxygen delivery to a cell implant. In one embodiment, the system includes a water electrolyzer, a cell capsule, a gas conduit, a total fluid pressure sensor, and a controller. The water electrolyzer generates gaseous oxygen with a variable output. The cell capsule includes a cell chamber adapted to hold cells. The gas conduit interconnects the water electrolyzer and the cell capsule to deliver gaseous oxygen generated by the water electrolyzer to the cell capsule. The total fluid pressure sensor is positioned at a location that provides a representative reading of the total fluid pressure within the cell chamber. The controller is electrically coupled both to the total fluid pressure sensor and to the water electrolyzer so that the controller may control the variable output of the water electrolyzer based on one or more sensed total pressure readings from the total fluid pressure sensor.