Abstract: The present invention relates to a nanovesicle comprising a heterodimeric G-protein coupled receptor, a method for preparing the nanovesicle, a field effect transistor-based taste sensor comprising the nanovesicle, and a method for manufacturing the taste sensor. The field effect transistor based taste sensor functionalized by the nanovesicle comprising the heterodimer G-protein coupled receptor according to the present invention has excellent sensitivity and selectivity and may highly specifically detect a sweet taste substance in real time, by using the heterodimeric G-protein coupled receptor and the nanovesicle comprising the same.

Abstract: The present disclosure provides methods and compositions for treatment, screening, diagnosis and prognosis of hepatocellular carcinoma with extrahepatic metastasis. Provided herein are methods and compositions for treatment, screening, diagnosis and prognosis of metastatic cancers. Also provided are antibodies and compositions for the treatment of cancers. Provided herein is therapeutic target for the treatment of cancers or as a marker for cancers. In particular, the protein represents a biological target against which affinity molecules including therapeutic antibodies, or other pharmaceutical agents, can be made. The disclosure also relates to the use of such affinity molecules for the treatment and/or diagnosis of cancers.

Abstract: A pathogen detection system includes pathogen detectors disposed in different locations, and a controller. The pathogen detectors include a first pathogen detector and a second pathogen detector. The first pathogen detector transmits a first detection result obtained as a result of pathogen detection to the controller, and the second pathogen detector transmits a second detection result obtained as a result of pathogen detection to the controller. In a case where the first detection result satisfies a predetermined condition, the controller causes the second pathogen detector to change a mode related to the pathogen detection from a first mode to a second mode.

Abstract: Kits containing a multiplexed chemiluminescent detection system and microfluidics devices and methods for detecting the presence and/or concentration of biotin and at least one target analyte in a sample are disclosed. The kits, microfluidics devices, and methods utilize singlet oxygen-activatable chemiluminescent compounds in combination with two or more fluorescent molecules that emit light at different wavelengths.

Abstract: The invention provides anti-hypusine antibodies and their use in detecting and isolating polypeptides containing hypusine and/or deoxyhypusine, as well as compositions and kits comprising the anti-hypusine antibodies.

Abstract: This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.

Abstract: The embodiments of the present disclosure provide a method for analyzing a body fluid proteome. The method comprises: obtaining a sample to be tested I enriched with low-abundance proteins by removing high-abundance proteins in an initial sample A using an affinity technique; obtaining a sample to be tested II enriched with low-abundance proteins by removing high-abundance proteins in an initial sample B using chemical precipitation, wherein the initial sample A and the initial sample B are obtained from a same body fluid sample of a same subject; obtaining a proteome data set I by performing proteomic analysis on the sample to be tested I; obtaining a proteome data set II by performing proteomic analysis on the sample to be tested II; and determining a final quantified proteome data set of the body fluid sample based on the proteome data set I and the proteome data set II.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.

Abstract: Biomarkers are provided that are predictive of a subject's responsiveness to a therapy comprising a JAK inhibitor. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities for a subject having, suspected of having, or at risk of developing Graft-Versus-Host Disease.

Abstract: Disclosed herein are methods that aid in the hyperacute diagnosis and evaluation of a human subject that has sustained or may have sustained an injury to the head, such as mild or moderate, severe, or moderate to severe traumatic brain injury (TBI), using an early biomarker, such as ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) glial fibrillary acidic protein (GFAP), or a combination thereof. Also disclosed here are methods that aid in the hyperacute determination of whether a human subject that has sustained an injury or may have sustained to the head would benefit from and thus receive a head computerized tomography (CT) scan based on the levels of UCH-L1.

Abstract: A method for discriminating between Parkinson's disease and multiple system atrophy, the method comprising the steps of: (1) preparing a solution containing ?-synuclein monomers having a tendency to produce rod-like aggregates and/or a solution containing ?-synuclein monomers having a tendency to produce twisted aggregates; (2) adding a biological sample from a subject to the solution(s) containing the ?-synuclein monomers prepared in step (1); (3) allowing the ?-synuclein monomers to aggregate in the solution(s) obtained in step (2); and (4) detecting ?-synuclein aggregates formed in step (3).

Abstract: The present disclosure is, in one aspect, directed to a locking assembly for securing a sample tube assembly to a sample manifold of a measurement system. The locking assembly includes a ramp block having one or more slots defined therein and configured to at least partially receive a portion of the sample tube assembly. The ramp block also includes a plurality of surface features defined therealong and configured to engage and move the sample tube assembly toward and into engagement with the sample manifold. The ramp block further is movable between a plurality of positions including an open position for allowing the sample tube assembly to be received through the one or more slots or openings, and a closed position substantially sealing the sample tube assembly against or within the sample manifold. Other aspects also are described.

Abstract: A cell picking device includes a stage, a sucker, a driver, a work content receiver, a registrar and a device controller. A sample container is placed on the stage. The driver is provided to execute sample scraping work and sample sucking work using a pipette tip attached to the sucker. In a case in which selection of work contents of the driver is received by the work content receiver, a work procedure including the received work contents of the driver is registered by the registrar. The work of the driver is controlled by the device controller in accordance with the registered work procedure.

Abstract: The invention relates to a device for determining a volume of gas in a sample contained in a vessel, the device comprising: a frame configured to attach the vessel; a needle having a longitudinal axis, comprising a proximal part and a distal part, the distal part being configured to pierce the vessel and the proximal part comprising a lumen; and an analysis compartment comprising a cell in fluid communication with the lumen of the proximal part of the needle. The invention also relates to a method for determining a volume of gas in a sample contained in a vessel.

Abstract: A method and apparatus to electronically sense air flow and close a switch when air flow is adequate to operate an electric heater, HVACR system, or other apparatus. The apparatus is more reliable than electro-mechanical devices often used for this purpose.

Abstract: A gyro sensor includes: a spring having an inner span beam connected to an outer span beam via a turnaround beam; and a fixed driver that laterally faces the outer beam. A first beam is provided to the structure side of the outer beam so as to face the outer beam. T1 is a width of a space between the outer beam and the structure, T2 is a width of a space between the inner and outer beams, and T2<T1.

Abstract: The present disclosure discloses a sample fixation mechanism for a test with a nano-probe, an apparatus for a test with a nano-probe, and a sample test method. The sample fixation mechanism includes a base having a first assembly surface; a holder having a second assembly surface matched with the first assembly surface, wherein the holder further has a fixation surface opposite to the second assembly surface, and the fixation surface is configured to be adhered and fixed with the sample; a lock structure having a locked state and an unlocked state, wherein in the locked state, the lock structure is capable of fixing the holder relative to the base, and in the unlocked state, the holder may be removed from the base.

Abstract: A socket for electrically connecting a first electrical component, the upper surface of which is pressed upon by a pressing member, and a second electrical component which is positioned below the first electrical component, said socket being equipped with: a socket main body which has a placement surface on which the first electrical component is placed; and a holding part which is provided to the socket main body, holds the first electrical component to the socket main body by engaging the first electrical component in a pressed state in which the first electrical component is pressed upon by the pressing member, and releases the engagement with the first electrical component when the pressing member moves a prescribed distance away from the position which corresponds to the pressed state.

Abstract: A probe card and a wafer testing assembly thereof are provided. The wafer testing assembly includes a printed circuit board, a space transformer, a plurality of copper pillars and a plurality of strengthening structure units. The printed circuit board includes a bottom surface and a plurality of first contacts arranged on the bottom surface. The space transformer includes a top surface and a plurality of second contacts. The second contacts are arranged on the top surface and corresponding to the first contacts. The copper pillars are respectively arranged between the first contacts and the second contacts. Two ends of each of the copper pillars are respectively electrically connected to the first contacts and the second contacts. The strengthening structure units are arranged on the bottom surface of the printed circuit board and respectively surrounding the copper pillars.

Abstract: An apparatus for analyzing currents in an electric load is provided with a current measuring circuit, which can be connected in series with the parallel circuit of the load branches, and a detector for detecting a change in the current when the switching element in a load branch is switched on or off. The apparatus also has an analysis unit which is connected to the control unit and to the detector and analyzes the temporal correlation of a control signal for switching a switching element in a load branch on or off with the detection of the change in the current and/or analyzes the change in the current at a plurality of times of switching a relevant switching element in a load branch or the switching elements in a plurality of load branches.

Abstract: An ingress protection assembly for leading a wire, such as a signal and/or a supply line, through a partition wall of an electrical device is provided. The ingress protection assembly includes a first wall section provided with a receiving slot extending through the first wall section in a lead-through direction and opening at an inlet facing in an assembly direction of the ingress protection assembly; and a second wall section provided with a counter slot extending through the second wall section in the lead-through direction and opening at a counter inlet facing against the assembly direction, wherein at least in a fully assembled state of the ingress protection assembly, the first wall section and the second wall section are at least partially superimposed in a projection along the lead-through direction such that the receiving slot and the counter slot together form an aperture configured for tightly encompassing the wire.

Abstract: The present disclosure provides a method and device for detecting insulation impedance of a photovoltaic inverter.

Abstract: A testing system includes a testing device including a display screen. The testing device can display, via the display screen, a representation of a vehicle and oscillators of the vehicle. The testing device transmits a test request that identifies a selected oscillator of the plurality of oscillators for testing. A vehicle receives the test request. An electronic control unit of the vehicle instructs the selected oscillator to generate test signals. The testing calculates a performance metric of the test signals. The testing device determines whether the selected oscillator is properly placed, functioning at a predetermined threshold, or both. Improperly placed or improperly functioning oscillators can be adjusted or replaced.

Abstract: A detection apparatus and an anti-bending device thereof are provided. The detection apparatus includes a probe card circuit board, at least one probe, and the anti-bending device. The probe card circuit board has a first board surface and a second board surface on opposite sides thereof. The at least one probe is mounted on the first board surface. The anti-bending device includes an anti-bending frame, at least one sensor, a processing circuit, and a transmission part. The anti-bending frame is mounted on the second board surface of the probe card circuit board, and the at least one sensor is disposed on the anti-bending frame or the probe card circuit board. The processing circuit is disposed inside the anti-bending frame. The transmission part is mounted on the anti-bending frame, and is electrically coupled to the processing circuit.

Abstract: Described herein are systems and methods for real-time fault detection in electrical circuits. Various embodiments provide a fault detection circuit that uses a resistor network that is controlled to detect an internal current leak in multiple directions, e.g., to ground or to a power supply. The magnitude of the leakage current may be estimated from voltage measurements at voltage pins. In addition, as part of circuit diagnostics, open and short circuit fault conditions may be identified by using current sources and measuring deflections at the voltage pins.

Abstract: An apparatus is provided that is implemented to enable multiple tests of different types, such as a direct current (DC) test and/or a radio frequency (RF) test of a semiconductor device. The apparatus includes a microelectromechanical systems (MEMS) switch block coupled between the semiconductor device and automatic testing equipment (ATE). The apparatus is configured to enable/disable a DC path or an RF path to switch between a DC test and an RF test without reconfiguring the connections between the semiconductor device and the ATE. The DC path is used to perform a DC contact test for one or more pins of the semiconductor device. The RF path is used to perform an RF test for the semiconductor device.

Abstract: The present disclosure relates to the field of design for testability of super-large-scale integrated circuits, and discloses a flexible configurable module (FCM) based chiplet test circuit. The core structure of the circuit is located at an interposer. The test circuit includes FCMs, a control signal configuration module and a test state control module, where the FCM adopts a two-way skew-symmetric structure to implement data transmission in the horizontal direction and the vertical direction; the control signal configuration module is connected to control signals of all the FCMs, so as to control the data transmission directions as well as switch on and switch off states of all the FCMs; and the test state control module controls the shift and update operations of data inside the FCMs and the control signal configuration module.

Abstract: A contact probe for electronic tests includes an upper part having an end portion for contacting a first electronic component; a lower part having an end for contacting a second electronic component; and an elongated and deformable central body interposed between the upper and lower parts. The lower part has an enlarged head with a lower surface intended to rest at least partially onto a horizontal surface, the lower surface having an inclination angle from the horizontal surface onto which it rests when the probe is unbuckled and, when the probe is buckled, it can assume a position in which the lower surface moves to rest entirely onto the horizontal surface, thereby eliminating the inclination angle.

Abstract: Devices for testing a DUT having a circuit coupled to an antenna are disclose. The device can include a DUT location for receiving a DUT, and an adapter or probe is used to wirelessly “over-the-air” (OTA) electronically test a DUT with an embedded antenna or antenna array with the measurement probe 140 located in close proximity to the DUT. The probe can be located very close to the DUT (e.g., in the near-field region). Although the probe is located in close proximity to the DUT antenna or antenna array elements it does not significantly disturb or interfere with probe during testing.

Abstract: An electronic device including a phase detector is provided. The phase detector includes a first transistor, a second transistor, a third transistor, a fourth transistor, and a first equalizer device. The first transistor has a first input terminal configured to receive a first signal. The second transistor has a second input terminal configured to receive a second signal. The third transistor is electrically connected to the first transistor and has a first output terminal. The fourth transistor is electrically connected to the second transistor and has a second output terminal. The first equalizer device is connected between the first output terminal and the second input terminal.

Abstract: A semiconductor device has a cell region including active regions that extend in a first direction and in which are formed components of transistors. The transistors of the cell region are arranged to function as a scan insertion D flip flop (SDFQ). The SDFQ includes a multiplexer serially connected at an internal node to a D flip-flop (FF). The transistors of the multiplexer include data transistors for selecting a data input signal, the data transistors having a first channel configuration with a first channel size, and scan transistors of the multiplexer for selecting a scan input signal, the scan transistors having a second channel configuration with a second channel size. The second channel size is smaller than the first channel size.

Abstract: A system and method for efficiently routing scan data between two dies used in three-dimensional packaging are described. In various implementations, a computing system includes at least a first semiconductor die (or first die) and a second die connected to one another within a three-dimensional (3D) package. The first die and the second die have multiple non-scan input/output (I/O) data channels between them for data transfer. The non-scan I/O data channels are partitioned into groups. The first die receives a given scan input data bit for testing a device under test (DUT) on the second die. The first die selects a first group of non-scan I/O data channels, and sends, to the second die, a copy of the given scan input data bit on each non-scan I/O data channel of the first group. The second die uses a voter circuit to determine the value of the given scan input data bit.

Abstract: An electronic assembly has a host wafer having a first circuit including wafer transistors and passive, non-transistor devices. Chiplets have a second circuit including at least one radio frequency (RF) transistor device. Electrical interconnects are between the chiplets and wafer. The electrical interconnects electrically connect the first circuit to the second circuits. Oscillators that have the wafer transistor, the RF transistor and the electrical interconnects produce a signal for built-in self-test circuits for testing an assembly design of the electronic assembly and speeds of the RF chiplet transistors.

Abstract: The present disclosure provides a method for modifying a gas density relay and a gas density relay having an online self-check function and a check method therefor. The gas density relay having an online self-check function is used for high-voltage and medium-voltage electrical devices, and includes a gas density relay body, a gas density detection sensor, a gas path blocking pressure regulation mechanism, an online check contact signal sampling unit and an intelligent control unit. The intelligent control unit controls a blocking member of the gas path blocking pressure regulation mechanism to move, so as to block a gas path between a first interface and a second interface.

Abstract: A learning method of a state estimation model includes training the state estimation model to learn a relationship of state estimation input data obtained by preprocessing terminal currents and terminal voltages of a secondary battery with a charge rate or a deterioration degree of the secondary battery. The state estimation input data includes time-series data of: difference gradients of terminal voltage differences with respect to terminal current differences; open circuit voltages; open circuit voltage change amounts; and integrated current values of the terminal currents.

Abstract: A battery characterization system includes a drive-sense circuit (DSC), memory that stores operational instructions, and processing module(s) operably coupled to the DSC and the memory. Based on a reference signal, the DSC generates a charge signal, which includes an AC (alternating current) component, and provides the charge signal to a terminal of a battery via a single line and simultaneously to senses the charge signal via the single line to detect an electrical characteristic of the battery based on a response of the battery. The DSC generates a digital signal representative of the electrical characteristic of the battery. The processing module(s), based on the operational instructions, generate the reference signal to include a frequency sweep of the AC component of the charge signal (e.g.

Abstract: A method includes performing a test for transformer rectifier unit (TRU) backfeed protection by removing AC power supplied to the TRU but keeping the TRU contactor closed for a first predetermined span of time. The method includes observing the TRU for a second predetermined span of time. The method includes determining if the contactor opens during the second span of time, that a TRU backfeed protection is functional and passes the test, and determining if the contactor does not open during the second span of time, that the TRU backfeed protection has failed the test.

Abstract: The present description concerns a circuit (5) for monitoring the operation of a component (1) associated with equipment (3), comprising: at least one device (100) for measuring one or a plurality of physical quantities associated with the operation of the component; and a circuit for calculating a value representative of a remaining lifetime of a component, said monitoring circuit (5) being linked to the equipment.

Abstract: A detection circuit for the on-board direct current/direct current (DC/DC) ground wire and an on-board device are provided. The circuit includes a digital signal process (DSP) controller, a detection circuit, a standby circuit for an on-board DC/DC converter, and a power-supply negative wire for the on-board DC/DC converter. The detection circuit includes a comparator, a first conductive branch, a second conductive branch, a third conductive branch. In this way, the detection circuit is connected between the DSP controller and the standby circuit for the on-board DC/DC converter, and the detection circuit is connected between the DSP controller and the power-supply negative wire for the on-board DC/DC converter.

Abstract: The innovative concept described herein relates to a sensor chip having at least two magnetic field sensors that are arranged adjacently to one another on the sensor chip and measure perpendicularly to the chip plane, wherein at least one of the magnetic field sensors has a planar coil arranged on it that is configured to generate a magnetic field directed perpendicularly to the chip plane. A controller is able to operate the magnetic field sensors in a calibration mode, in which the planar coil generates the magnetic field. For the purpose of calibrating the magnetic field sensors, a differential measurement may be taken that involves the response signal from one magnetic field sensor being subtracted from the response signal from the other magnetic field sensor.

Abstract: The present invention relates to a sensor suite comprising at least one sensor. More particularly, the present invention relates to a sensor suite for measuring absolute and/or relative position, location and orientation of an object on or in which the sensor suite is employed. The present invention further relates to improved, novel sensor types for use in the sensor suite. More particularly, the present invention relates to an improved, novel magnetometer that is self-calibrating and scalable. Still more particularly, the present invention relates to such a magnetometer that is miniaturized. Further embodiments of the present invention relate to systems and methods for providing location and guidance, and more particularly for providing location and guidance in environments where global position systems (GPS) are unavailable or unreliable (GPS denied and/or degraded environments).

Abstract: To increase, in a magnetic sensor having a magnetoresistive strip and a ferromagnetic film, a magnetic bias to be applied to a magnetoresistive element by magnetically coupling the magnetoresistive strip and ferromagnetic film. A magnetic sensor 1 includes a magnetoresistive strip S, an insulating film 13 that covers the magnetoresistive strip S, and ferromagnetic films M1 and M2 formed on the insulating film 13 and arranged in the x-direction through a magnetic gap G extending in the y-direction. The ferromagnetic films M1 and M2 overlap a plurality of hard magnetic members H through the insulating film 13. This allows two adjacent hard magnetic members H to be magnetically coupled through the ferromagnetic films M1 and M2. This makes it possible to increase the magnetic bias to be applied to a magnetoresistive element R without involving an increase in the size of the hard magnetic member H.

Abstract: Systems and method for the delivery of a pump laser using optical diffraction are described herein. In certain embodiments, a system includes a substrate and a waveguide layer formed on the substrate. The waveguide layer includes a first waveguide of a first material configured to receive a probe laser for propagating within the first waveguide. The waveguide layer additionally includes a second waveguide configured to receive a pump laser for propagating within the second waveguide. Further, the waveguide layer includes one or more diffractors configured to direct a portion of the pump laser out of the second waveguide and through the first waveguide.

Abstract: Embodiments of the present application provide a radio frequency head coil (300), RE head coil. The RE head coil (300) comprises a coil former (310) comprising at least a first leg and a second leg arranged at a distance from each other to define a space there between, the coil former (310) being at least sectionally flexible and having at least one first fastening portion (315, 316) arranged adjacent to the space (314), and a respiratory mask (320) comprising a gas outlet (324) and at least one second fastening portion (322, 323), wherein in an operable condition in which the RE head coil (300) is adapted to be arranged at least in sections around a head of a patient (S) and in which the second fastening portion (322, 323) is adapted to be fastened to the first fastening portion (315, 316), the gas outlet (324) is disposed within the space (314).

Abstract: An MRI system including a main magnet defining a volume, an imaging region disposed within the volume. The main magnet is configured to produce a uniform main magnetic field within the volume, wherein the uniform magnetic field is oriented along a patient axis. The system includes a gradient magnetic coil assembly disposed within the volume and configured to generate a spatially varying magnetic field across the imaging region. The gradient magnetic coil assembly includes a first coil configured to generate a magnetic field in a first axis, a second coil configured to generate a magnetic field in a second axis, and a third coil configured to generate a magnetic field in the patient axis. The system also includes a passive gradient shield disposed between the main magnet and primary gradient magnetic coil assembly, the passive gradient shield can include a continuous cylindrical layer of high permeability, low electrical conductivity material.

Abstract: Systems and methods are provided herein for determining whether to extend scanning performed by a magnetic resonance imaging (MRI) system. According to some embodiments, there is provided a method for imaging a subject using an MRI system, comprising: obtaining data for generating at least one magnetic resonance image of the subject by operating the MRI system in accordance with a first pulse sequence; prior to completing the obtaining the data in accordance with the first pulse sequence, determining to collect additional data to augment and/or replace at least some of the obtained data; determining a second pulse sequence to use for obtaining the additional data; and after completing the obtaining the data in accordance with the first pulse sequence, obtaining the additional data by operating the MRI system in accordance with the second pulse sequence.

Abstract: An MRI system and method for generating MR images is provided. An MR signals acquisition unit is configured to generate a main magnetic field, orienting the magnetization of blood within a subject, and first inversion/non-inversion RF pulses such that predetermined sequences of blood boli with inverted/non-inverted magnetization are generated. First inversion/non-inversion MR signals can be acquired, which are caused by the influence on the magnetization by the first inversion/non-inversion RF pulses. MR images may be generated by an image generation unit based on imaging MR signals, acquired after the sequences of inverted and non-inverted blood boli have been flowed from the first region to the part to be imaged, and the predetermined sequences. An evaluation unit is configured to evaluate the inverting of the magnetization in the first region based on the first inversion and/or non-inversion MR signals.

Abstract: Examples of systems and methods for calibrating or operating a magnetic sensor for sensor temperature or operating conditions are provided. The magnetic sensor can comprise a dual magnetometer sensor that comprises a first, low-power-consumption magnetometer (e.g., a magneto-inductive magnetometer) and a second higher-power-consumption magnetometer (e.g., a magneto-resistive magnetometer). The second magnetometer can have a lower unit-to-unit variation in temperature calibration parameters and can be used to temperature-correct readings from the first magnetometer. The magnetic sensor can dynamically switch between usage of the first magnetometer and the second magnetometer in order to provide a dynamic sample rate that can depend on conditions within the sensor or external to the sensor.

Abstract: Provided is a system 10 for remote activation of an emergency radio beacon by a Search and Rescue (SAR) party, the system 10 comprising a controller 12 operatively arranged in signal communication with an emergency radio beacon 14, a positioning module 16 arranged in signal communication with the controller 12 and configured to operatively provide spatial positioning data to the controller 12, and a receiver 18 arranged in signal communication with the controller 12 and configured to operatively receive an activation signal 20. The controller 12 is configured to activate the beacon 14 upon receipt of the activation signal 20 and to provide the spatial positioning data of a potentially lost or distressed party to the beacon 14 for transmission along with an emergency signal 22.

Abstract: Systems and methods of estimating a location of a mobile computing device are provided. For instance, acoustic signals can be received from one or more transmitting devices associated with a real-time locating system. A set of peaks can be selected from the received acoustic signals. A first set of transmitter locations can be assigned to the selected set of peaks. The first set of transmitter locations can be specified by an acoustic model specifying a plurality of transmitter locations within an acoustic environment in which the one or more transmitting devices are located. A first model path trace associated with the first set of transmitter locations can be compared to the received acoustic signals. A location of the mobile computing device can be estimated based at least in part on the comparison.