Abstract: The present invention relates to antibodies which specifically bind to human IL1RAP and my also bind to cynomolgus monkey and/or mouse IL1RAP. The present invention also relates to the use of such antibodies to diagnose and treat human disease.

Abstract: The present invention relates to antibodies which specifically bind to human IL1RAP and my also bind to cynomolgus monkey and/or mouse IL1RAP. The present invention also relates to the use of such antibodies to diagnose and treat human disease.

Abstract: Described herein are humanized anti-TL1A antibodies and pharmaceutical compositions for the treatment of inflammatory bowel disease (IBD), such as Crohn's Disease (CD) and ulcerative colitis (UC).

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: Disclosed herein are B cell maturation antigen binding proteins with improved binding affinities and improved ability to mediate killing of cancer cells expressing B cell maturation antigen (BCMA). Pharmaceutical compositions comprising the binding proteins disclosed herein and methods of treatment of a cancer or a metastasis thereof using such formulations are further provided.

Abstract: Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates (ADCs) such as those comprising a splicing modulator) that bind to BCMA are disclosed. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering a composition provided herein.

Abstract: The present invention concerns methods for treating multiple sclerosis (MS) in a patient, and an article of manufac-ture with instructions for such use.

Abstract: The present disclosure generally relates to binding agents, such as antibodies and antigen binding fragments thereof, that are capable of binding to trophoblast cell surface antigen-2 (TROP2). Also disclosed herein are binding agents that are capable of targeting TROP2-expressing tumor cells and their use for the treatment of cancer. Single domain antibodies that specifically binds to amino acid residues of the extracellular domain of TROP2 are provided.

Abstract: Provided herein are, inter alia, antigen-binding molecules with binding specificity to cluster of differentiation 3 T cell receptor (CD3), antigen-binding molecules with binding specificity to prostate-specific membrane antigen (PSMA), cleavable linker sequences, and protease-activatable bispecific fusion proteins such as protease-activatable T cell engagers, as well as uses and methods of treatment.

Abstract: The present disclosure is related to methods of reducing blood pressure or effecting a hemodynamic change in a subject, the methods comprising administering to the subject a pharmaceutical composition comprising an agonist of natriuretic peptide receptor 1 (NPR1) (e.g., an agonist anti-NPR1 antibody).

Abstract: The present application provides anti-PLA2G2D constructs that bind to PLA2G2D (e.g., anti-PLA2G2D antibodies), nucleic acid molecules encoding an amino acid sequence of the anti-PLA2G2D, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of preparing the anti-PLA2G2D construct, pharmaceutical compositions containing the anti-PLA2G2D construct, and methods of using the anti-PLA2G2D construct or compositions.

Abstract: Provided herein are novel bispecific antibodies for the treatment of chronic pain. The bispecific antibodies comprise two or more antigen binding components, wherein at least one antigen binding component is capable of binding to human ADAMTS5, and wherein at least one antigen binding component is capable of binding to nerve growth factor (NGF).

Abstract: Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided.

Abstract: A multispecific antigen-binding protein including: (a) a first antigen-binding portion capable of recognizing the first antigen, where the first antigen is targeted to antigens associated with tumorigenesis or progression; (b) a second antigen-binding portion, where the second antigen-binding portion is an innate immune cell agonist; and (c) a third antigen-binding portion capable of recognizing the third antigen, where the third antigen regulates tumor microenvironment by regulating normal and abnormal angiogenesis. The embodiments further provide a pharmaceutical composition including the multispecific antigen-binding protein and a pharmaceutically acceptable carrier, and use of the multispecific antigen-binding protein and the pharmaceutical composition in the preparation of a drug for the treatment of cancer.

Abstract: The present invention relates to combination therapy using a binding agent that binds to human CD40 and to human CD137 in combination with a checkpoint inhibitor to reduce or prevent progression of a tumor or treating cancer.

Abstract: Cellulose acetate particles include cellulose acetate as a main component, in which a total degree of acyl substitution of the cellulose acetate is 0.05 or more and less than 0.70.

Abstract: Provided is a method of continuously producing a depolymerized cellulose ether that is space-saving and highly productive, and is capable of reducing adhesion of a cellulose ether powder body to reactors and producing a depolymerized cellulose ether with a suppressed degree of yellowness and contaminants. The method includes: bringing a raw material cellulose ether that is of a temperature of 3° C. to less than 40° C. and is continuously supplied from a raw material tank 1 to a moisture conditioning tank 2 into contact with a water vapor B to obtain a moisture-conditioned cellulose ether; heating the moisture-conditioned cellulose ether to obtain a temperature-raised cellulose ether, continuously bringing a gaseous hydrogen chloride into contact with the temperature-raised cellulose ether to obtain a depolymerized cellulose ether product; and mixing the depolymerized cellulose ether product with a basic compound to obtain a depolymerized cellulose ether.

Abstract: Provided is a crosslinked elastomer that can easily be decrosslinked. The crosslinked elastomer is obtained through crosslinking of a diene elastomer that has a vinyl bond content of 30 mass % or less and a weight-average molecular weight of 1,000 or more. The crosslinked elastomer includes a diboronic acid ester skeleton unit represented by a specific general formula (1) at a crosslinking site.

Abstract: Provided is a method of crosslinking an elastomer that uses an elastomer that can easily be crosslinked and decrosslinked. The method of crosslinking an elastomer includes a step of causing contact of an elastomer including a monoboronic acid ester-containing functional group represented by a specific general formula (4) with a diboronic acid compound in the presence of a solvent. The solvent has an SP value of not less than 10 (cal/cm3)1/2 and not more than 13 (cal/cm3)1/2 and includes at least a single solvent having an SP value of not less than 8 (cal/cm3)1/2 and not more than 10 (cal/cm3)1/2.

Abstract: The present disclosure relates to compounds of Formula I, element tags comprising soft metals, and methods and kits therefore for performing mass cytometry.

Abstract: An object of the present invention is to provide, for example, a polyethylene powder that can produce a shaped article excellent in balance between mechanical strength and a rate of thermal shrinkage even when shaped at a high speed. Provided is a polyethylene powder having intrinsic viscosity IV of 1.5 dL/g or more and 15.0 dL/g or less measured in accordance with ISO1628-3 (2010), an amorphous moiety thickness of 5.3 nm or larger and 12.0 nm or smaller, and a crystallite size of 13.9 nm or larger and 18.0 nm or smaller obtained by a reflection method of X-ray diffraction.

Abstract: The present invention provides a chlorinated polyvinyl chloride resin that enables excellent continuous productivity in molding and that enables a molded article to have both processability and unevenness-preventing properties. Provided is a chlorinated polyvinyl chloride resin having, in Raman measurement by Raman spectroscopy, an average of a ratio (A/B) of a peak intensity A observed in a range of 660 to 700 cm?1 to a peak intensity B observed in a range of 600 to 650 cm?1 of 0.50 to 2.00, and a standard deviation of the A/B of 0.090 or less.

Abstract: Cross-linked polyvinyl polymers comprising charged groups and methods of making are disclosed. The polymers are effective and durable adsorbent of dyes from aqueous solutions. Also, a method of removal of dyes from contaminated water is disclosed.

Abstract: A method may include: introducing a water-based drilling fluid comprising an aqueous base fluid and a branched polyvinyl alcohol shale stabilizer into a drill string; extending a wellbore using the drill string through a subterranean formation comprising a shale; and allowing the branched polyvinyl alcohol shale stabilizer to interact with the shale to at least partially inhibit the shale.

Abstract: The invention relates to a polymerizable composition, comprising a crosslinker comprising a —Sn- moiety and having at least two polymerizable groups, wherein n is an integer of from 2 to 8; one or more monomers, each monomer having at least one C?C double bond capable of undergoing a polymerization reaction; and a polymerization initiator. The invention also relates to methods of making a reversibly-crosslinked polymer by reacting the components of the polymerizable composition, and the resulting reversibly-crosslinkable polymer and its reprocessing/recycling.

Abstract: A composition includes one or more copolymers of one or more vinylidene aromatic monomers and one or more unsaturated compounds containing nucleophilic groups, and the copolymer has on average about 0.01 to about 15.0 percent by weight of nucleophilic groups pendant from the copolymer. The copolymer is chain extended and/or branched by one or more copolymers of one or more vinylidene aromatic monomers and one or more unsaturated compounds having electrophilic groups, or a portion of the chains of the copolymer of one or more vinylidene aromatic monomers and one or more nucleophilic groups are crosslinked with other chains of the copolymer of one or more vinylidene aromatic monomers and one or more nucleophilic groups by ionic bonding of anions formed from the pendant nucleophilic groups with a metal cation having a valence of 2 or greater or complexation between pendant acid groups and metal oxides.

Abstract: A compound that is suitably used for formation of an optically anisotropic film having excellent reverse wavelength dispersibility and moisture-heat resistance; a polymerizable composition; an optically anisotropic film; an optical film; a polarizing plate; and an image display device. The present invention relates to a compound represented by Formula (I-1) P1-SP1-Ar1-Mes-Ar2-SP2-P2 (I-1).

Abstract: Provided is an aqueous composition comprising dispersed particles that comprise a polymer, wherein the polymer comprises, by weight based on the weight of the polymer, a) 60% to 99.95% polymerized units of one or more (meth)acrylate ester, b) 0.05% to 6% polymerized units of one or more N-vinyl lactam, c) 0% to 39.95% polymerized units of one or more other monomers. Also provided is a method of making that composition, a process for producing an article using that composition, and a method of bonding two substrates using that article.

Abstract: Embodiments of the present invention include a grafted aqueous carboxymethyl cellulose (CMC) binder comprising CMC chemically bonded with a monomer, where the CMC has a weight ratio of water to CMC of from about 99.9:0.1 to about 1,000:500, wherein the monomer is characterized by a weight ratio of monomer to CMC of from about 1:1 to about 1:1,000, and non-woven fabrics and articles including CMC binders, and methods of manufacture of the same. Aspects of the invention include a method of synthesizing a grafted aqueous carboxymethyl cellulose (CMC), the method comprising: contacting CMC with water to form a CMC solution. contacting the CMC solution with an initiator; contacting the CMC solution with a monomer to start grafting polymerization reaction between the CMC and a monomer. In some embodiments, the binder and non-woven fabrics including the same are non-toxic and biodegradable.

Abstract: The present inventive concept relates to a PMMA resin that has improved impact resistance and scratch resistance at the same time, while maintaining excellent optical properties of conventional PMMA resins, and a preparation method thereof. More specifically, the present inventive concept relates to a crosslinked PMMA resin comprising PMMA chains crosslinked among each other and polyamine as a crosslinking agent, wherein the polyamine is coupled between the PMMA chains to yield the crosslinked PMMA resins, wherein the polyamine is selected from the group consisting of diamine, triamine and tetramine that have a C2-C50 linear, branched or cyclic group.

Abstract: What is provided is a graft copolymer (A) obtained by graft-polymerizing a monomer component (a) to a rubber-based polymer, in which the monomer component (a) contains 60% to 85% by mass of a mixture (a1) of ?-methylstyrene and an aromatic vinyl compound other than ?-methylstyrene with respect to the total mass of the monomer component (a), and the rubber content of the graft copolymer (A) is 35% by mass or more with respect to the total mass of the graft copolymer (A).

Abstract: Compatibilizers are disclosed that enable the formation of stable alloys of fluoropolymers with cyclic olefin copolymers (COC). The alloys are useful for many purposes, such as high frequency electronics. Methods of making the compatibilizer and the alloy are further provided.

Abstract: Alkylphenol-aldehyde resins and alkoxy alkylphenol-aldehyde resins that have a natural aldehyde component for use in oilfield applications. A method for synthesizing an alkylphenol-aldehyde resin having a natural aldehyde component, a method for synthesizing an alkoxy alkylphenol-aldehyde resin having a natural aldehyde component, and methods for asphaltene inhibition, viscosity reduction, and emulsion breaking using the disclosed resins.

Abstract: A method of making a bio-based, slow recovery polyurethane foam includes preparing an aqueous mixture that includes a resin and an additive. The resin, the additive, or both, can be bio-based. The method can include combining a hydrophilic polyurethane prepolymer with the aqueous mixture. The method can include chemically reacting the hydrophilic polyurethane prepolymer with the aqueous mixture to create a foam mixture. Chemically reacting the hydrophilic polyurethane prepolymer with the aqueous mixture may generate a foaming agent that includes carbon dioxide.

Abstract: High solids curable film-forming compositions and coating kits are provided, comprising: (a) a polyisocyanate curing agent; and (b) a film-forming component comprising at least one of (i) a secondary-hydroxyl functional (meth)acrylic polyol having pendant ester functional groups and a weight average molecular weight of 4000 to 8000; and (ii) a reactive constituent comprising: (1) a polymeric polyol comprising a polyester polyol and/or an addition polymer that is different from (i); and (2) an organic medium comprising a hydrophobic and/or sterically hindered reactive diluent having hydroxyl functional groups. Alternatively, the film-forming component (b) comprises the secondary-hydroxyl functional (meth)acrylic polyol (i) and optionally at least one of (1) and (2) above. The (meth)acrylic polyol comprises 20 to 35 percent by weight residues of an epoxy functional ethylenically unsaturated monomer. Methods of improving appearance of an effect pigment-containing coating layer on a substrate are also provided.

Abstract: An aqueous UV-curable dispersion at least includes a reaction product composed of a) at least one polyisocyanate having an average isocyanate functionality of at least 2.2, of which preferably at least one polyisocyanate is an oligomeric polyisocyanate having urethane, biuret, allophanate, iminooxadiazinedione and/or isocyanurate structural units; b) at least one monohydroxy-functional compound containing acryloyl groups, c) at least one component which contains nonionic hydrophilizing groups and has at least one further isocyanate-reactive group and d) at least one diol, triol, diamine and/or triamine, the reaction product having no ionogenic or ionically hydrophilizing groups.

Abstract: Embodiments of this invention are directed to bio-based epoxy compositions. and method of their preparation and use. Other embodiments are directed to cured bio-based epoxies, and manufactured articles having bio-based epoxy coatings, adhesives. or composites.

Abstract: The present disclosure provides for latent curing accelerators as well as compositions containing such a latent curing accelerator with a substance to be cured (e.g., an epoxy resin). The latent curing accelerators comprise a urea compound and an encapsulant system having a polyphenol resin and/or at least one additional excipient. Methods of making and use are further provided.

Abstract: The invention provides for polymer structures and their preparation and resulting novel functionalities including open-shell character and high intrinsic conductivity with wide-range tenability. Electrical conductivity can be further modulated by introducing or blending with materials, fillers, dopants, and/or additives. The materials or resultant composites of the invention can be processed by various techniques into different forms to realize multiple applications.

Abstract: In a poly(3-hydroxypropionic acid) block copolymer according to the present invention, 3-hydroxypropionic acids and lactone monomers or, additionally, lactide monomers are introduced so as to improve various physical properties such as the thermal property, crystallinity and tensile property of a biodegradable polymer, and thus the application fields thereof can be expanded.

Abstract: Herein, we enable a record-high FDCA reaction rate of 416 ?mol h-1 cm-2 (1872 ?mol h-1) at 100% FDCA selectivity using a ZnCo2O4 electrocatalyst in a near-neutral media that allows high concentration (i.e. 1M) of HMF, with assistance of an in-situ alkaline modification strategy that further enhances the reaction rate. In the light of the significantly improved FDCA production, we demonstrate production of PEF bioplastic from a biomass-derivative fructose, highly competitive to the petroleum-based production of PET plastics as indicated by our techno-economic analysis.

Abstract: The present disclosure provides polyester elastomers, compositions, and methods of preparing such elastomers and compositions. The polyester elastomers in the present disclosure are prepared by reacting at least one activated polycarboxylic acid with at least one polyol. The crosslinked polyester elastomer compositions can be formulated into various personal care formulations.

Abstract: A curable resin composition for obtaining a cured product having improved heat resistance contains a component (A), which is a polyphenylene ether resin, in an amount of 100 parts by weight, and a component (B), which is a diallyl ether compound represented by general formula (1), in an amount of 0.1 to 4.9 parts by weight: wherein R1 to R8 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms.

Abstract: A polyamic acid manufacturing system for manufacturing a polyamic acid is disclosed using, as raw materials, a first solution in which a polyaddition-type first polymerizable compound is dissolved and a second solution in which a polyaddition-type second polymerizable compound that reacts with the first polymerizable compound through polyaddition is dissolved. The polyamic acid manufacturing system may include: a first supply part for supplying the first solution; a second supply part for supplying the second solution; a first combining part; and a first reaction part, thereby producing a first polymerization solution in which the polyamic acid is dissolved. Further, the polyamic acid manufacturing system may include: a first supply step of supplying the first solution; a second supply step of supplying the second solution; a first combining step; and a first reaction step, thereby producing a first polymerization solution in which the polyamic acid is dissolved.

Abstract: A polyimide random copolymer has a structure represented by formula (I). A method for preparing the polyimide random copolymer, a membrane made of the polyimide random copolymer, and a method for preparing a polyimide-based hollow fiber membrane are also provided. A system for purifying helium gas and a method for purifying helium gas are related to the membrane made of the polyimide random copolymer.

Abstract: The present disclosure is related to providing a polyamic acid that can form a polyimide exhibiting a low dielectric property and a low hygroscopic property, and a polyamic acid composition, polyimide, polyimide film, and printed circuit board that are produced by using the polyamic acid. A polyamic acid that is a product obtained by polyaddition reaction between an ester-type acid dianhydride (A) and at least two diamines (B), wherein a dimer diamine (B1) is contained at a molar ratio of 0.3 or more relative to an entirety of the diamine component.

Abstract: The present invention aims to provide a method for producing a sulfur-containing polymer such as polyarylene sulfide which has few by-products in the polymerization reaction and little effect caused by the catalyst residue used, on optical properties or other properties. The present invention relates to a method for producing a sulfur-containing polymer, the method including polymerizing a monomer component containing at least one of a disulfide compound or a thiol compound using a catalyst, the catalyst containing an iron-containing substance, an amount of iron in the iron-containing substance being 50 mol % or less relative to 100 mol % of the monomer component.

Abstract: A curable composition for preparing a low density cast silicone foam includes a first part and a second part. The first part includes particular amounts of an alkenyl-terminated polyorganosiloxane; an alkenyl-substituted copolyorganosiloxane; an alkenyl-substituted MQ polyorganosiloxane; a cure catalyst; an inorganic filler; and a chemical blowing agent. The second part includes a hydride-substituted polyorganosiloxane. The resulting silicone foams advantageously have a density of less than 240 kg/m3; and a closed cell content of at least 50%. Cured silicone foams and methods for the manufacture thereof are also described.

Abstract: Provided are a novel silicone-based polymer compound with excellent mechanical properties and a silicone-based polymer material containing the silicone-based polymer compound. The silicone-based polymer compound of the present invention is a silicone-based polymer compound (H) having a polysiloxane backbone as the main chain, wherein the polysiloxane backbone has at least one host group in a side chain, and the host group is a monovalent group formed by removing one hydrogen atom or one hydroxy group from a cyclodextrin or a cyclodextrin derivative.

Abstract: A hyperbranched boric acid modified phthalonitrile monomer as well as a preparation method and use thereof are provided. The preparation method of the hyperbranched boric acid modified phthalonitrile monomers includes: a reaction in the mixture containing a boron source, a phenol compound, and a solvent to prepare a compound with a B—O structure; and a reaction in the mixture containing the compounds with the B—O structure, 4-nitrophthalonitrile, a catalyst, and a solvent to prepare the hyperbranched boric acid modified phthalonitrile monomers.