Abstract: The disclosure provides example apparatus and methods for automatically adjusting a socket size of a prosthesis. The apparatus includes (a) the prosthesis having a socket configured to receive a limb, (b) a first opening in a socket wall, (c) a first panel aligned with the first opening, (d) a first actuator coupled to the first panel and to the prosthesis, the first actuator is configured to advance and retract the first panel, (e) a first sensor coupled to the socket wall and configured to obtain limb-to-socket gap data, and (f) a processor coupled to the first actuator and the first sensor, wherein the processor is configured (i) to receive the limb-to-socket gap data, (ii) to determine a socket-size adjustment based on the limb-to-socket gap data and a predetermined socket-fit value, (iii) to generate and (iv) to send a command with the socket-size adjustment to the first actuator.

Abstract: An adjustable prosthetic device and a fitting tool for positing the prosthetic device on a limb are described. The prosthetic device comprises two or more adjustable paddles that are movably coupled with an adapter via connectors. The connectors allow the paddles to be repositioned relative to a user's limb. The paddles are sized and dimensioned to capture lost motion between the limb and the prosthetic device through skeletal compression and tissue displacement. The fitting tool comprises two or more compression bars that removably couple with the two or more paddles of the prosthetic device. The fitting tool also comprises two or more linear actuators that control the positions of the compression bars and the paddles relative to the limb.

Abstract: The present invention relates to a braiding method for a nasal sinus stent, comprising: providing a filament; providing a braiding tool having a longitudinal central axis, wherein the braiding tool comprises a first shaping part and a second shaping part which are axially spaced from each other, wherein the first shaping part is provided with n first anchor points, and the second shaping part is provided with n second anchor points; forming an initial configuration stent by around a circumferential direction of the braiding tool, allowing a single filament starting from 1st first anchor point on the first shaping part, coming across m1 vertex intervals to extend towards the second anchor point, and then coming across m2 vertex intervals to extend towards the first anchor point, so as to complete a first “V” shaped braiding path, and then repeating the “V” shaped braiding path until the single filament returns to the 1st first anchor point, wherein the initial configuration stent has a circumference and n vert

Abstract: Example medical stents are disclosed. An example stent includes a tubular framework including an inner surface, an outer surface and a lumen extending therethrough. Additionally, the stent includes a tissue ingrowth scaffold extending along a portion of the outer surface of the tubular framework, wherein the tissue ingrowth scaffold is spaced radially away from the outer surface of the tubular framework to define an expansion cavity therebetween and wherein the tissue ingrowth scaffold permits tissue ingrowth along a portion thereof. Further, the stent includes an expandable member positioned within at least a portion of the expansion cavity.

Abstract: An endoprosthesis has an expanded state and a contracted state, the endoprosthesis includes a stent having an inner surface defining a lumen, having an outer surface, and defining a plurality of apertures through the outer surface, wherein the apertures are arranged in a micropattern; and a coating (e.g., polymeric coating) attached to the outer surface of the stent. The coating includes a base and a tissue engagement portion including a second surface facing outwardly from the stent, the tissue engagement portion including a structure that defines a plurality of holes extending inwardly from the second surface toward the base. The holes are arranged in a micropattern. When the endoprosthesis is expanded to the expanded state in a lumen defined by a vessel wall, the structure applies a force that may reduce stent migration by creating an interlock between the vessel wall and the endoprosthesis.

Abstract: A method of treating diverticulitis while maintaining the bioactivity of the diverticulum. The devices and methods include placing an endoscopic device within a colonic lumen relative to at least one diverticulum and inserting a plurality of particles into the at least one diverticulum. The plurality of particles can include magnetic particles, non-magnetic particles, or both. The plurality of particles can partially or totally occlude the diverticulum preventing unwanted material from entering the diverticulum. Additionally, the plurality of particles can include antimicrobial and therapeutic layers that can treat diverticulitis and prevent or minimize diverticulitis from occurring.

Abstract: A stent delivery system includes a core member and an expandable member coupled to the core member distal segment. A stent extends along the core member distal segment such that an inner surface of the stent is positioned over the expandable member. The stent has a primary heat-set configuration where the stent is radially expanded, and a secondary heat-set configuration where the stent is radially compressed. The expandable member is adapted to radially expand at least a portion of the stent from a radially compressed configuration toward a radially expanded configuration.

Abstract: Valve assemblies for use with expandable devices that are positioned within remote cavities and more particularly relates to the catheters/conduits used to inflate these devices with fluid.

Abstract: A patellofemoral support comprises a sleeve and a strap assembly. The strap assembly is arranged to extend helically about the sleeve. A buttress is arranged to removably secure to an inside surface of a first portion of the strap assembly or to the sleeve.

Abstract: A support device provides elevation and support for a patient's foot and limits lateral and medial rotation of the foot relative to the knee. This protects the knee from injury during healing. The device includes a generally flat main body, two spaced-apart lateral ridges, and a medial depression between the lateral ridges that provides a support surface on which the foot may be positioned. The lateral ridges can extend to a height above the support surface so that inner side surfaces of the lateral ridges are adjacent to a majority of a foot placed in the medial depression. The support surface can include a heel aperture extending through the main body to provide a continuous heel pocket allowing the heel to remain freely suspended when the foot is placed in the device. The device can additionally or alternatively include a slidable base allowing the device to better slide on a surface enabling the user to perform therapeutic exercises.

Abstract: A nasal shaper configured to be introduced into a nose of a subject, the nasal shaper including two tubes suitable for each being introduced into a nostril of the nose, connected together at their lower ends by a connecting bridge and a plate attached to the connecting bridge and extending opposite the connecting bridge relative to the tubes, the plate being configured to exert a pressure on the philtrum of the subject when the tubes are each introduced into a nostril of the nose.

Abstract: A medical device for placing on a human penis, e.g., post penile enhancement procedure, includes a flexible sleeve having a proximal end and a distal end, the proximal end being sized and dimensioned to be positioned over the base of the penis, the sleeve being configured and sized to extend from the base of the penis and along the body of the penis, the distal end being sized and dimensioned to terminate just below the corona of the glans of the penis. The distal end may include a flange that extends radially outwards from an outer surface of the sleeve, and a thickness of the sleeve spaced away from the flange along a longitudinal axis of the sleeve may be about 4 mm-5 mm.

Abstract: A body support wrap adapted to encompass a body article of a user while elastically encompassing and supporting a fluid communication element, the body support wrap includes first and second flexible elastomeric surrounding sidewalls that are adjacent to one another and offset on an upper end forming a mouth opening and the first and second sidewalls are evenly displaced on a lower end forming a closed attachment, wherein an interior pocket is formed therebetween the first and second sidewalls that the fluid communication element is disposed through the mouth opening, wherein operationally via the first and second sidewalls elasticity the fluid communication element is held anyplace within the interior pocket in multiple positions adjacent to the user for the convenience and comfort of the user.

Abstract: An ostomy attachment including: a flexible annular seal configured to at least partially surround a stoma, the flexible annular seal including a first face and a second face; wherein the first face and the second face are bounded by an inner rim and an outer rim, wherein the inner rim is concentrically arranged within the outer rim; and an ostomy seal liner configured to engage with the inner rim of the flexible annular seal; wherein the ostomy seal liner includes one or more stabilising extensions, wherein the one or more stabilising extensions extend from the ostomy seal liner radially outward and over the first face of the flexible annular seal; and wherein the one or more stabilising extensions are in contacting relation with the first face of the flexible annular seal. Methods of manufacturing ostomy attachments and methods of use are also provided.

Abstract: An ostomy barrier appliance for attaching an ostomy appliance to peristomal skin surrounding a stoma is provided. The ostomy barrier appliance includes a skin barrier, an inlet opening for receiving a stoma, and a convexity adjusting device arranged adjacent the skin barrier. The convexity adjusting device is configured to adjust the convexity of the skin barrier.

Abstract: Fluid thermal management storage apparatuses and methods are disclosed herein. An example apparatus can include a dewar vessel having a heatsink mounted thereon. The dewar vessel can be configured to receive and retain a bag of whole blood. A thermoelectric sub-assembly is mounted to the heatsink, where the thermoelectric sub-assembly includes a solid-state thermoelectric element, a fan disposed below the solid-state thermoelectric element for circulating air within the dewar vessel, and a controller having a processor and memory. The processor executes instructions to maintain the bag of whole blood at a safe operational temperature for a period of time.

Abstract: An ophthalmic surgical system includes a robotic arm disposed above a patient's eye. A positioning camera is disposed on the robotic arm and positioned to visualize the patient's eye. A processor is electrically coupled to the positioning camera. The processor is configured to receive an indication of a position of the robotic arm relative to a fixed datum, determine a focal length between the positioning camera and the patient's eye, compare the focal length to the position of the robotic arm, and determine a patient eye level relative to the fixed datum.

Abstract: A corneal irrigation system, for removing a color pigment(s) from an intracorneal channel, includes a syringe, an irrigation device, and a flexible tube coupling the syringe to the irrigation device. The irrigation device includes a handle, having a distal end and a proximal end, that is coupled to the cannula. The handle also includes a lumen. The cannula includes (i) a shaft section having a first end that is coupled to the handle's proximal end, (ii) a curved section having a blunt tip, wherein an exterior surface of the curved section includes a rough-surface region, and (iii) a lumen having an opening in the rough-surface region, the lumen extending from the first end of the shaft section toward the blunt tip. The cannula's lumen is coupled to the handle's lumen.

Abstract: A system includes a radiation source and a controller. The controller is configured to designate, for irradiation, multiple target regions on an eye of a patient, and to perform an iterative process that includes, during each iteration of the process, acquiring an image of the eye, based on the image, calculating a location of a different respective one of the target regions, processing the image so as to identify any obstruction at the location, and provided no obstruction at the location is identified, causing the radiation source to irradiate the location. Other embodiments are also described.

Abstract: The present invention relates to an ophthalmic treatment device, a control method therefor and a fundus lesion treatment method, the ophthalmic treatment device comprising: a treatment beam generation unit for generating a treatment beam; a beam delivery unit for forming a path through which the treatment beam generated from the treatment beam generating unit is irradiated into a patient's fundus; and a control unit for controlling the beam delivery unit to irradiate the treatment beam into a location adjacent to the lesion area of the fundus.

Abstract: Methods and related apparatus for real-time process monitoring during laser-based refractive index modification of an intraocular lens. During in situ laser treatment of the IOL to modify the refractive index of the IOL material, a signal from the IOL is measured to determine the processing effect of the refractive index modification, and based on the determination, to adjust the laser system parameters to achieve intended processing result. The signal measured from the IOL may be a fluorescent signal induced by the treatment laser, a fluorescent signal induced by an external illumination source, a temporary photodarkening effect, a color change, or a refractive index change directly measured by phase stabilized OCT.

Abstract: The present disclosure provides a removable eyewear shielding device, an eyewear comprising a removable eyewear shielding device, and methods of uses thereof for reducing eye radiation exposure, reducing ipsilateral brain radiation exposure, reducing FGI-induced lens opacification, reducing cataract development, or protecting an eye or ipsilateral brain from radiation exposure.

Abstract: A patient positioning system for positioning a patient in the lateral decubitus position in preparation for a lateral approach spinal procedure. The patient positioning system includes a base section having a head bolster, an axillary bolster, and a hip bolster. The system also includes a lateral arm support configured to support the arms of the patient in a generally parallel position extending in the anterior direction away from the torso of the patient, and a leg bolster positionable between the legs of the patient and configured to support the legs of the patient and space the legs of the patient from one another.

Abstract: A shipment package includes container blanks and lid blanks. Each container blank has a first length and is foldable into a casket container. Each container blank has first and second folded over ends. The container blanks are stacked such that the first folded over ends of the plurality of container blanks are at least partially aligned, and such that the second folded over ends of the plurality of container blanks are at least partially aligned. Each lid blank is foldable into a casket lid having at least approximately the first length, and is configured to cover an interior of the casket container. Each lid blank is folded over a widthwise fold line such that the lid blank has a length less than the first length. A first lid blank is disposed between two container blanks, and between folded over ends of one of the container blanks.

Abstract: A wheelchair lift can be easily installed on a standard truck or SUV, wherein the wheelchair lift includes an extendable and retractable platform, a motorized lifting mechanism, a remote control, and a safety stop mechanism that prevents the wheelchair from rolling off of the platform during use. The wheelchair lift is mountable underneath the driver's side or passenger's side of the vehicle, and folds into a compact unit that is positioned along the base of the vehicle chassis in a position where a running board or step might normally be located. The wheelchair lift may be easily removed from one vehicle and installed on another vehicle.

Abstract: A patient transfer apparatus is provided and includes a frame, a seat assembly coupled to the frame, and a track assembly coupled to the frame. The track assembly includes a moveable track for traversing stairs and a motor configured to drive the track. The apparatus further includes a control system. The control system includes a controller configured to control the motor and to adjust a speed of the apparatus based on an occupancy of the seat assembly upon traversing the stairs based on a current to the motor upon traversing stairs.

Abstract: An overhead arm assembly for a patient support apparatus includes a user interface device. The user interface device has a support structure for supporting a personal digital assistant and a charging port for personal digital assistant.

Abstract: Systems, devices and methods are described for mounting medical equipment on IV poles, bed rails and other supporting structures in medical facilities including operating rooms and critical care sections. A system including a mounting hanger and corresponding equipment housing is disclosed that allows quick mounting and dismounting of equipment from a supporting structure. The novel structural design of mounting hanger including a symmetrical t-slot feature and a plunger lock allows a piece of equipment to be mounted on a supporting structure in multiple orientations as per the requirement which allows a user to optimize the placement of equipment in the medical environment.

Abstract: A patient transfer device for transferring a patient placed on a movable sheet from a first surface to a receiving surface, said patient transfer device including first and second laterally spaced apart retractable pulling members, at least one motor operatively connected to the pulling members so as to allow retraction of the pulling members by means of the motor, where the pulling members comprise a bobbin and a wire, where the patient transfer device comprises an absorbent member removably arranged around the wire. Accordingly, the wire may be cleaned in a reliable manner.

Abstract: A patient positioning system comprising a wedge comprising a wedge body and a plurality of sensors coupled to the wedge body, wherein the wedge body is configured to deform in response to a pressure applied to the wedge body, the plurality of sensors coupled to the wedge body, wherein the plurality of sensors are configured to sense pressure applied to the wedge body.

Abstract: The invention provides an exercise machine (10) of the type which have pedals (38) or foot plates through which a person can, in use, transfer kinetic energy to the machine, which machine comprises a means for vibrating the pedals or foot plates during exercise. The exercise machine includes a mechanism (40) to engage or disengage the vibration.

Abstract: A rope-driven soft hand function rehabilitation device includes four finger exoskeleton mechanisms, a thumb exoskeleton mechanism, and a soft rubber glove. An index-finger exoskeleton mechanism includes an index-finger distal phalanx loop, an index-finger middle phalanx loop, and an index-finger proximal phalanx loop which are mutually connected via a hinge structure. The thumb exoskeleton mechanism includes a thumb proximal phalanx loop and a thumb distal phalanx loop which are connected via a hinge structure. The rope is fastened to the hand function rehabilitation device via an aluminum sleeve which prevents the rope from slipping off during finger flexion/extension and abduction/adduction when the fingers are pulled by the rope at the palm and the hand back.

Abstract: A device for treatment of the Peyronie's disease, containing a hollow cylindrical body placed in the bed of a fixed base plate for precision positioning of the penis with respect to the center of the plaque in its subcutaneous tissue, wherein adjacent to the cylindrical body is the face of the shock wave generator firmly connected to a supporting rigid navigation frame with the possibility of travel in three mutually orthogonal directions and three rotations in three mutually perpendicular planes to ensure the localization of the highest shock wave energy level in the second focal point of the shock wave generator which is identical to the position of the center of the plaque, and the space between the inner and outer walls of the cylindrical body is filled with degassed water with a temperature close to the patient's temperature.

Abstract: A vibrating masturbator device with sterilization and charging functions, including a masturbator device and a charging box for placing and charging the masturbator device. In an embodiment, the masturbator device includes a body, a switch control member on the body, charging contacts exposed on the body, a masturbator device battery electrically connected to the charging contacts, and a vibration motor powered by the battery. In an embodiment, the masturbator device charging box includes a storage compartment for receiving the masturbator device, charging contacts corresponding in position to the charging contacts on the masturbator device, a charging box power source electrically connected to the charging box charging contacts, and a sterilization device arranged to sterilize the masturbator device while it is being charged in the charging box, the sterilization device being powered by the charging box power source.

Abstract: A temperature-controlled massage node that imparts either or both a heating or cooling effects is provided, which may be attached to a massager to impart a heating or cooling effect on a user with a massage effect, or optionally, without a massage effect. The temperature-controlled massage node may be affixed to the massager or may be removably coupled. The temperature-controlled massage node may be powered by the same power source as the massager or may include an independent power source located, for example, in the massage node. The massage node may be used with a massager that provides percussive massage effects, such as a massage gun, or may be used with a vibrating massager. Optionally, the massage node may include independent power, a controller and a motor to supply both a vibrating massage effect and hot and cold effect, either alone or in combination.

Abstract: A system to provide physical therapy in the form of heating, cooling and/or percussion, comprising: a device that contains a battery, a motor, and a switch to turn the device on or off or put the device in heating mode or put the device in cooling mode or put the device in percussion mode; wherein the device contains a motor and a pushing rod that supply the movement that results in percussion of a removable heating/cooling attachment and a removable percussion attachment; wherein the front of the device connects to the removable heating/cooling attachment that contains an electronic component to control heating or cooling and a cooling fan; wherein the removable heating/cooling attachment can be used for heating or cooling; wherein a housing shell for the heating/cooling attachment is made of plastic, foam, or metal, or any combination of plastic, foam and metal; wherein the front part of the heating/cooling attachment is made of metal that has the capability to be in contact with human skin in order to prov

Abstract: A wearable apparatus recognizes an exercise move of a user based on motion information of the user, determines torque reference information based on a result of the recognizing, determines torque command information based on the determined torque reference information and a predetermined factor, and outputs a torque based on the determined torque command information.

Abstract: A rollator to aid mobility is described. The rollator comprises an A-frame with two pairs of uprights, each pair of uprights connected by at least one respective hinge to allow each pair of uprights to be folded or pivot front-to-back and a seat disposed between the two pairs of uprights, the seat foldable side-to-side. To fold compactly the rollator comprises an X-shaped cross-linkage comprising four linkage members. A method of manufacturing the rollator is also disclosed. The four linkage members may extend from a respective upright to a central hub underneath the seat. The cross-linkage may fold or pivot at the central hub in both front-to back and side-to-side dimensions when the rollator is folded away.

Abstract: An external defibrillator system for assisting manual delivery of chest compressions and ventilations to a patient by a rescuer as cardiopulmonary resuscitation (CPR) includes a speaker, and a processor, memory, and associated circuitry coupled to the speaker. The processor is configured to initiate prompting for the chest compressions and the ventilations manually delivered to the patient by the rescuer as CPR, control the speaker to generate first auditory cues for the chest compressions, and control the speaker to generate second auditory cues for the ventilations with a different sound than the first auditory cues for the chest compressions. The first auditory cues and the second auditory cues assist the rescuer in timing the delivery of the chest compressions and the ventilations.

Abstract: Spa systems may be used all year round and in colder weather provide an enjoyable experience for users through the cold ambient outdoor temperature and the heated water of the spa. However, failures in respect of the water circulating pump and/or heater of the spa system either mechanically, electrically or through overall power outages mean the water in the spa system and its pipework can easily freeze if ambient conditions are cold enough leading to cracks in the spa system or pipes and hence leaks when the water thaws requiring costly repair or replacement of components or entire systems. Accordingly, a freeze protection system is provided that uses a backup thermal management system discretely or in combination with other backup systems. These freeze protection systems offering backup when mechanical failures, electrical failures etc. arise by providing thermal input to the spa system through alternate thermal paths and providing alarms.

Abstract: The invention provides a blister package for at least one pharmaceutical or food supplement product of the gum type, comprising a support shell having a flat portion and at least one cavity formed on said flat portion, said at least one cavity being defined by a lateral wall extending from said flat portion and a bottom wall linked to said lateral wall, at least one gum comprising at least one gelling agent and being molded into said at least one cavity, a cover film fixed on said flat portion and closing said at least one cavity, at least one tearing notch formed both on said support shell and cover film, and at least one tearing channel formed at least on said lateral wall and facing said at least one tearing notch, said at least one tearing channel defining a complementary channel shape formed on said molded gum.

Abstract: A locking cover for a container having a neck comprising: a cage made from plastic; a body made from plastic, which is fastened around the cage, the body comprising a central orifice; a cap configured to close the central orifice, the cap comprising a flat head to cover the orifice and fastening lugs caught between the cage and the body. Each fastening lug has a breakable zone, and the cap is made from a plastic material, different from the plastic material of the cage and from the plastic material of the body, the plastic material of the cap being chosen to have a resistance to rupture reduced by a dose of gamma irradiation for sterilizing the locking cover.

Abstract: Disclosed is a pharmaceutical container comprising a lumen defined in part by a wall, the wall having an interior surface facing the lumen, an outer surface, and a coating set on the interior surface comprising a pH protective layer, wherein the pH protective layer is applied using atomic layer deposition.

Abstract: A hygienic oral pacification device includes a fluid-filled bladder. The bladder includes a nipple and alveolar ridge-mating flanges. The bladder is dynamically shaped and allows for pressures provided by the suckling child to re-shaping the bladder and flanges. A bite-block extends into the bladder to maintain a fluid path from nipple to flanges. As the child completes the suckling cycle, the bladder nipple is depressed and fluid is forced in the engorging flanges. The flanges thus cover the alveolar ridges and fill the vestibules. Hard pads set along a superior surface of the nipple are compressed against the maxilla palate and provide lateral force to encourage expansion of the palate. The nipple may be bifurcated into left and right opposing lobes which can split laterally to enhance lateral force on maxilla.

Abstract: Magazines that include a supporting member such as a strap, rod or chamber and one or preferably a plurality of portable medicament cases that each include a medicament provided in a package. Each case has first and second housing members that are configured to form a medicament package receiving cavity when joined together. The housing members mate together in a sealed configuration that prevents moisture or contaminants from entering into the cavity. The magazines are configured for containing a plurality of medicament cases for administration of medicaments to a group of people. Also included is a method of administering medications to mass casualties of multiple persons that are in need thereof. The medicaments are rapidly disintegratable and can include a dye that stains the person's mouth so that medical personnel can determine who has been treated with the medicament.

Abstract: A method of desensitizing microbes to pro-biofilm amino acids and amino acid derivatives in plasma comprising administering a sufficient amount of glycerol. A method of sensitizing microbes to anti-biofilm amino acids and amino acid derivatives in plasma comprising administering a sufficient amount of glycerol. Methods of increasing a plasma concentration of glycerol comprising administering a sufficient amount of glycerol. A method of treating an infection and/or contamination comprising applying glycerol and anti-biofilm amino acids and/or amino acid derivatives to a surface to be treated and/or water to be treated. A method of treating a biofilm producing viral infection comprising administering a sufficient, non-toxic concentration of glycerol. A method of treating a protozoal infection comprising administering a sufficient, non-toxic concentration of glycerol.

Abstract: Provided herein are methods for increasing the therapeutic efficiency of oncolytic bacterial therapeutics. Bacterial oncolytic therapies, especially the ones targeting tumor hypoxia such as C. novyi-NT, often encounter incomplete tumor clearance in less hypoxic tumoral areas and severe inflammatory reactions. In this study, we explored immune-modulating preconditioning to suppress the host neutrophils and significantly enhanced the antitumor efficacy of C. novyi-NT in animal models, including an orthotopic brain tumor model in rabbits. The optimized preconditioning agent, hydroxyurea, is clinically approved and C. novyi-NT has demonstrated manageable safety and promising antitumor responses in clinical trials. Thus, the proposed preconditioning of neutrophil suppression is readily translatable to patients undergoing C. novyi-NT trials or other oncolytic biologic therapies and could improve outcome.

Abstract: Dosage forms, drug delivery systems, and methods related to sustained release of dextromethorphan or improved therapeutic effects are disclosed. Typically, bupropion or a related compound is orally administered to a human being to be treated with, or being treated with, dextromethorphan.

Abstract: The present disclosure generally relates to pharmaceutical compositions and combinations comprising an androgen receptor N-terminal domain inhibitor or an inhibitor and a second therapeutically active agent, such as an CDK4/6 inhibitor, a Pin1 inhibitor (inhibitor of peptidyl-prolyl cis/trans isomerases), or an antiandrogen. In particular, the present disclosure relates to pharmaceutical compositions and combinations useful for treatment of various cancers, for example breast cancer and prostate cancer. Further, the present disclosure relates administering an androgen receptor N-terminal domain inhibitor in combination with radiation therapy for treatment of various cancers.

Abstract: Compositions and methods to produce adhesive articles with active agents concentrated at the substrate contacting surface. The active agents are applied in powder form, or in combination with a liquid or gel vehicle, to the substrate contacting surface of an adhesive layer of an adhesive article. The active agent compositions are directly applied to the adhesive layer, or are first applied to a release liner, which is then brought into contact with the adhesive layer to dispose the active agent compositions to the substrate contacting surface of the adhesive layer. Upon application of the adhesive article to a substrate, the active agent is delivered to a region of interest on the substrate.