Patents Issued in October 24, 2024
  • Publication number: 20240350385
    Abstract: A cyanoacrylate polymer film-forming solution and treatment for inhibiting sweat and enhancing grip performance. The solution includes a polymer film-forming compound that, once formed into a film, dries the surface of the skin, blocks sweat pores to inhibit sweating without leaving a toxic byproduct or burdensome residue and enhances grip performance by reducing slippage and improving grip texture. The treatment includes a method of applying the cyanoacrylate polymer film-forming solution to the desired location, rubbing solution into a desired location, allowing the solution to dry, and repeating until desired effect is achieved.
    Type: Application
    Filed: April 19, 2024
    Publication date: October 24, 2024
    Inventors: Mark J. Miller, Seonyoung Kim
  • Publication number: 20240350386
    Abstract: The presently claimed invention relates to oxidative hair colouring compositions comprising at least one alkalizing agent of general formula (I), The oxidative hair colouring compositions comprising at least one compound of general formula (I) provide the combined benefit of delivering broader colour shade palette and improved colour intensity with a low level of hair damage, while ensuring low or no odour levels.
    Type: Application
    Filed: August 9, 2022
    Publication date: October 24, 2024
    Inventors: Viktoriya SENDYUREVA, Simon GODFREY, Axel MEYER, Emad BADALI-BAGHAL, Teresa BURGAHN, Bjoern HOFFMANN, John LANKHOF
  • Publication number: 20240350387
    Abstract: The invention relates to a composition comprising at least one oxidation dye, 1,3-propanediol, at least one alkaline agent and at least one fatty substance other than fatty acids.
    Type: Application
    Filed: June 29, 2022
    Publication date: October 24, 2024
    Inventors: Sarah BOULEMNAKHER, Maria NIETO, Julie BRUYERE, Hanène MOUEDDENE, Marie GIAFFERI, Laurence COTTARD-MEI
  • Publication number: 20240350388
    Abstract: Cosmetic and pharmaceutical formulations comprising specific amino acid combinations are described herein. Such formulations strengthen and enhance skin epithelial cell barrier function, thereby reducing moisture loss from the skin and restoring skin's structural integrity, epithelial differentiation, intercellular adhesion, and intracellular signaling and/or promoting maintenance of these features. Formulations described here comprise a therapeutically effective amount of free amino acids or a peptide combination of amino acids and either a therapeutically effective amount of a plant extract for skin barrier repair or a therapeutically effective amount of a retinoid for improving skin moisture. Also provided are injectable formulations described here for treating a subject suffering from osteoarthritis or symptoms thereof.
    Type: Application
    Filed: July 3, 2024
    Publication date: October 24, 2024
    Inventors: Apostolos Pappas, Olga Ilnytska
  • Publication number: 20240350389
    Abstract: A method for dyeing keratinous material, such as human hair, is described. Initially, a first agent is applied to the keratinous material. The first agent includes less than 10 wt % water, at least one organic silicon compound selected from the group comprising silanes having one, two, or three silicon atoms, and at least one chromophoric compound. A second agent is applied to the keratinous material which is still impinged with first agent. The second agent includes water. The first and second agents are allowed to act upon the keratinous material. The first and second agents are then rinsed.
    Type: Application
    Filed: July 12, 2022
    Publication date: October 24, 2024
    Inventors: Carolin KRUPPA, Torsten LECHNER, Marc NOWOTTNY, Carsten MATHIASZYK, Andreas WALTER, Juergen SCHOEPGENS, Avni TAIRI, Phillip JAISER
  • Publication number: 20240350390
    Abstract: The present invention relates to sulfate-free cleansing compositions comprising at least one zwitterionic surfactant and at least one human milk oligosaccharide as well as to a method of increasing the foaming properties of cleansing compositions comprising at least one surfactant by incorporation of one or more human milk oligosaccharides into said cleansing composition.
    Type: Application
    Filed: August 23, 2022
    Publication date: October 24, 2024
    Inventors: Lise Anne KOHLER, Pascal Christian SIEBER
  • Publication number: 20240350391
    Abstract: Cosmetic compositions. kits comprising cosmetic compositions. and methods and uses thereof are provided. wherein the cosmetic compositions comprise a tetrapeptide capable of stimulating protein synthesis, skin repair and regeneration in combination with oligo-alpha glucans.
    Type: Application
    Filed: August 25, 2022
    Publication date: October 24, 2024
    Inventors: Clare Helena O'Connor, Michael David Bell, Victoria Lynne Newton
  • Publication number: 20240350392
    Abstract: Compositions, and methods and uses thereof are provided, wherein the compositions comprise a biologically active agent and one or more solvents that dissolve the biologically active agent.
    Type: Application
    Filed: August 25, 2022
    Publication date: October 24, 2024
    Inventors: Mark Johnson, Beverley Jane Elms, Paul James Tomlinson
  • Publication number: 20240350393
    Abstract: Disclosed is an aqueous personal care composition, particularly in hair care composition comprising 0.1 to 10 wt. % of low substituted carboxymethyl cellulose (CMC) alone or in combination with 0.01 to 10 wt. % of at least one natural or synthetic polymer, 0.01 to 60 wt. % of at least one additive; and water; wherein, the low substituted carboxymethyl cellulose has an average degree of carboxymethyl substitution (DS) per anhydroglucose unit is in the range of from about 0.5 to about <0.7.
    Type: Application
    Filed: July 27, 2022
    Publication date: October 24, 2024
    Applicant: ISP Investments LLC
    Inventors: MICHAEL FRANZKE, Lidia KULCSAR, Carolie Claudine ALONSO, Gijsbert KROON
  • Publication number: 20240350394
    Abstract: The present invention provides a non-therapeutic cosmetic method for treating a skin surface, said method comprising the combination of a medium with ultrasound waves, wherein the medium includes a suitable cosmetic product. One aspect according to the present invention provides a non-therapeutic cosmetic method for reducing wrinkles on a skin surface, the method comprising the steps of applying an ultrasound transmission medium onto the skin surface to be treated, wherein the medium includes cosmetic actives/formula and applying ultrasound waves to the skin surface with the applied medium. The ultrasound waves produce acoustic output. The ultrasound waves have a frequency of 10 KHz to 50 MHz, preferably 30 KHz to 20 MHz, and more preferably 1 MHz to 10 MHz. The ultrasound waves are generated so that the ultrasound waves propagate in the skin to a maximum depth of 3 mm from the skin surface and generate a rise in temperature of the skin at the application zones.
    Type: Application
    Filed: July 15, 2022
    Publication date: October 24, 2024
    Applicant: L'Oreal
    Inventors: Chin Kai Lee, Rosario Antonelli, Shahid Naseer
  • Publication number: 20240350395
    Abstract: The present invention relates to a hyaluronic acid (HA) filler composition using polyethylene glycol (PEG) and glycolic acid (GA) as crosslinking agents and a method for preparing same. The present invention is characterized by preparation through the crosslinking of hyaluronic acid (HA) with polyethylene glycol (PEG) and glycolic acid (GA). According to the present invention, polyethylene glycol (PEG) and glycolic acid (GA) are alternately added and stirred to crosslink liquefied hyaluronic acid particles, and viscoelasticity is controlled by adjusting the amounts of PEG and GA added, and thus, a filler composition that is elastically applicable to a treatment area is provided.
    Type: Application
    Filed: July 7, 2022
    Publication date: October 24, 2024
    Inventors: Dokyoung LEE, Eunyoung LEE
  • Publication number: 20240350396
    Abstract: The instant disclosure is skin perfecting and tightening composition that provide an instantaneous and dramatic improvement to the appearance of skin, e.g., by reducing the appearance of wrinkles, eye bags, pores, and skin imperfections such as scarring, dark spots (and uneven skin tone), dark circles, and roughness. The skin perfecting and tightening compositions comprise: (a) one or more polysaccharides with amine groups; (b) silica particles; (c) one or more acids, salts thereof, or a combination thereof; (d) optionally, one or more fatty compounds; (e) optionally, one or more water-soluble solvents; and water. The skin perfecting and tightening compositions exhibit excellent transparency, haze, and gloss characteristics appropriate for application to the skin, which are particularly long lasting.
    Type: Application
    Filed: April 17, 2024
    Publication date: October 24, 2024
    Applicant: L'OREAL
    Inventors: Chunwei WU, Hy Si BUI
  • Publication number: 20240350397
    Abstract: A coating-forming composition for forming a coating composed of a fiber-containing deposit directly on skin via electrostatic spraying, the coating-forming composition containing the following component (A), component (B), and component (C): (A) one or more volatile substances selected from the group consisting of water, alcohols, and ketones, (B) a water-insoluble polymer having fiber-forming ability, and (C) one or more polyols. Where (B1) a polymer with a molecular weight of 1×105 or more is contained as the component (B), and a mass content ratio of the component (B1) to the component (B), ((B1)/(B)), is 0.5 or more, and a mass content ratio of the component (B) to the component (C), ((B)/(C)), is 1 or more.
    Type: Application
    Filed: August 25, 2022
    Publication date: October 24, 2024
    Applicant: KAO CORPORATION
    Inventors: Ryota NAKAJIMA, Soyoung PARK, Nobuyuki ASAMI, Satoshi OZAWA
  • Publication number: 20240350398
    Abstract: The present invention relates to a purified product of a citrus oil, in which an oil derived from a citrus peol is used as a raw material, a content of linoleic acid is 0.015 parts by mass or less with respect to 1 part by mass of citral, or 0.063 parts by mass or less with respect to 1 part by mass of linalool, or 0.083 parts by mass or less with respect to 1 part by mass of decanal, and a content of sesquiterpene hydrocarbons is 20 mass % or less.
    Type: Application
    Filed: October 5, 2022
    Publication date: October 24, 2024
    Applicant: TAKASAGO INTERNATIONAL CORPORATION
    Inventors: Naoto TERADA, Tadahiro HIRAMOTO
  • Publication number: 20240350399
    Abstract: Disclosed herein are water-based lubricating compositions. The water-based lubricating composition may comprise at least one part or extract from an okra plant species and/or a flaxseed plant species. Also disclosed herein are articles comprising the water-based lubricating composition, possible applications and uses of the water-based lubricating composition, along with a possible method of synthesis.
    Type: Application
    Filed: July 15, 2022
    Publication date: October 24, 2024
    Applicant: LifeStyles Healthcare Pte. Ltd.
    Inventors: KC Nguyen, Atip Boombumrung, Chayapon Ngowprasert, Chayaporn Pongthanomsak, Yatima Kanghae, Andrea Pavlovicova
  • Publication number: 20240350400
    Abstract: A method for reducing the appearance of fine lines or wrinkles, treating skin inflammation, or reducing the appearance of reddened or erythemic skin is disclosed. The method can include applying to skin having a fine line or wrinkle, having inflammation, or having a reddened or erythymic appearance a composition that includes tetrahexyldecyl ascorbate and Acmella oleracea extract, wherein application of the composition to the skin reduces the appearance of the fine line or wrinkle, treats skin inflammation, or reduces the appearance of the reddened or erythemic skin.
    Type: Application
    Filed: July 1, 2024
    Publication date: October 24, 2024
    Inventors: Geetha KALAHASTI, Patricia JACOBY, Milagros SANCHEZ, Shona BURKES-HENDERSEN, David GAN
  • Publication number: 20240350401
    Abstract: The disclosure concerns viscous or gelled delivery systems based on oily nano-domains dispersed in a viscosified/gelled continuous aqueous phase, and suitable for prolonged and/or sustained topical delivery of various active compounds.
    Type: Application
    Filed: June 27, 2024
    Publication date: October 24, 2024
    Applicants: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd., LYOTROPIC DELIVERY SYSTEMS LTD
    Inventors: Nissim GARTI, Sharon GARTI LEVI
  • Publication number: 20240350402
    Abstract: The present invention relates to compositions, systems, and methods for treating a subject with a corneal injury and/or an existing corneal scar using a composition comprising an ACE-2 receptor antagonist (e.g., losartan, telmisartan, valsartan, olmesartan, candesartan, irbesartan, eprosartan, azilsartan, or losartan metabolite EXP3174). In certain embodiments, the ACE-2 receptor antagonist is present in the composition at a concentration of about 0.2 mg/ml to 0.9 mg/ml or about 0.1 mg/ml to 2.0 mg/ml.
    Type: Application
    Filed: August 30, 2022
    Publication date: October 24, 2024
    Inventor: Steven E. WILSON
  • Publication number: 20240350403
    Abstract: Apparatus and associated methods relate to a dehydrated herbivore therapeutic delivery wafer. In an illustrative aspect, a dehydrated herbivore dewormer wafer may, for example, include an edible wafer composition including pieces of a first natural carbohydrate spread throughout the edible wafer configured such that the pieces of the first natural carbohydrate are visible on an exterior surface of the edible wafer. For example, the edible wafer may include a second natural carbohydrate coupled to at least some of the visible pieces of the first natural carbohydrate such that the natural carbohydrates may be sensed by an equine to be within the edible wafer composition. The edible wafer may include an active ingredient evenly distributed throughout the edible wafer composition. The edible wafer may include scorelines defining predetermined sections selectively separable from the edible composition wafer, configured such that each predetermined section comprises a predetermined amount of the active ingredient.
    Type: Application
    Filed: March 20, 2024
    Publication date: October 24, 2024
    Inventor: Allen Bubela II
  • Publication number: 20240350404
    Abstract: An orally dissolvable or chewable tableted powder formulation, includes one or more mesoporous silica carriers loaded with a liquid cannabinoid suspension or solution; one or more water-soluble agents in an amount of 20-80% by weight of the tableted powder formulation; and one or more flavors, wherein the liquid cannabinoid suspension or solution includes one or more cannabinoids and one or more non-volatile solvents in a weight ratio of cannabinoid to solvent of 10:1 to 1:10.
    Type: Application
    Filed: March 21, 2024
    Publication date: October 24, 2024
    Applicant: Fertin Pharma A/S
    Inventors: Sanne Skov Jensen, Gitte Nykjær Nikolajsen, Simon Laursen, Dorthe Schackinger Boesen
  • Publication number: 20240350405
    Abstract: An oral disintegrating tablet that forms liquid crystalline particles or liquid crystalline bulk phase upon disintegration. The oral disintegrating tablet is fast disintegrating following contact with saliva and/or the oral mucosa but also provides slowed delivery of the active ingredient to avoid the difficulties associated with the speed of delivery of an active ingredient through the oral mucosa.
    Type: Application
    Filed: July 1, 2024
    Publication date: October 24, 2024
    Inventors: David KANNAR, Gregory Yu Foo Szto, Tomer Madmon
  • Publication number: 20240350406
    Abstract: A pharmaceutical composition for administering directly to the pulmonary tract of a subject includes a salt of triiodothyronine and a pharmaceutically acceptable buffer, adjusted to a pH of 5.5-8.5. The composition can be administered prophylactically or therapeutically to a subject to treat lung inflammation or pulmonary edema.
    Type: Application
    Filed: December 14, 2023
    Publication date: October 24, 2024
    Inventors: David H. Ingbar, Timothy P. Rich, Robert J. Schumacher, Jianxun Lei, Maneesh Bhargava
  • Publication number: 20240350407
    Abstract: A composition of food or therapeutic and other substances for administration as a cloud of droplets, the cloud comprising readily-soluble droplets having a median size range of approximately 3 microns to approximately 20 microns, or 5 microns to 10 microns, or 6 microns to 10 microns, for introduction to an animal via an ortho-nasal or retro-nasal route. Agonists or antagonists may include one or more of the following: sodium iodide, sodium chloride, magnesium chloride, capsaicin, piperine, linalool, ground cinnamon, a cannabinoid, pimento, onion, clove, thyme, ginger, menthol, or TRPV antagonists, and chocolate, Irish cream, caramel, lemon, lime, mango, raspberry, watermelon, blueberry, strawberry, mint, popcorn, meat, Resolvin D2 or nicotine. Devices for delivering compositions as an aerosol are described.
    Type: Application
    Filed: July 2, 2024
    Publication date: October 24, 2024
    Inventors: David A. Edwards, Tom Devlin
  • Publication number: 20240350408
    Abstract: A polyfunctional radical scavenger hydrogel formulation providing extended protection of the extracellular space within a wound site. The polyfunctional radical scavenger hydrogel formulation is generally formed from a hydrogel, a first radical scavenger and a second radical scavenger differing from the first radical scavenger with respect to at least one property. A portion of the first radical scavenger included with the formation and/or second radical scavenger included within the formulation may be dissolved, suspended and/or bonded to a polymer of the hydrogel.
    Type: Application
    Filed: May 27, 2024
    Publication date: October 24, 2024
    Inventors: Richard M Millis, Jeffrey A Niezgoda, Rajagopalan Sridhar
  • Publication number: 20240350409
    Abstract: Provided are transdermal delivery formulations, and methods for the manufacture thereof, for the epicutaneous administration of drugs and nutrients to a human subject or domestic, veterinary, or agricultural animal. Transdermal delivery formulations disclosed herein comprise a homogenous mixture of (a) a transdermal accelerant comprising a weak organic acid having a pKa greater than 2.0 and (b) a microemulsion comprising a nonionic emulsifier, water, and a cis-unsaturated long-chain fatty acid. Fatty acid microemulsions are combined with the acidified transdermal accelerants having a pH greater than 1.0 (typically from 1.5 to 2.5) to yield a homogenous transdermal delivery formulation comprising fatty acid micelles and/or liposomes that encapsulate one or more compound, such as a nutrient or a drug, and incorporate one or more cis-unsaturated fatty acid having a 12-26 carbon chain that includes one or more double bond in a cis configuration.
    Type: Application
    Filed: May 3, 2023
    Publication date: October 24, 2024
    Applicant: LifeActive, Inc.
    Inventor: Calvin Dexter Morris
  • Publication number: 20240350410
    Abstract: Compositions and methods are provided for stabilization of RNA encapsulated by lipid nanoparticles during lyophilization. Novel lyophilization processes are provided. These techniques may be used to prevent the need for cold chain storage.
    Type: Application
    Filed: August 16, 2022
    Publication date: October 24, 2024
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Rushit LODAYA, Patrick POHLHAUS, Elizabeth ZECCA, Jinjin ZHANG, Adora PADILLA, Erwan BOURLÈS, Julie ENERT
  • Publication number: 20240350411
    Abstract: Provided herein are methods of purifying liposomal formulations by washing with acidic aqueous solutions.
    Type: Application
    Filed: July 15, 2022
    Publication date: October 24, 2024
    Inventors: Paul TARDI, Leon WAN, Shyam Madhusudan GARG, Jun GAO, Philippe LEGROS
  • Publication number: 20240350412
    Abstract: Provided is a method for preparing a pouch filling material including step S1 of preparing a solid-phase filling material including a binder, step S2 of preparing a particle size control solution including a processing aid, and step S3 of spraying the particle size control solution onto the solid-phase filling material while stirring the solid-phase filling material.
    Type: Application
    Filed: April 19, 2024
    Publication date: October 24, 2024
    Applicant: KT&G Corporation
    Inventors: Sung Je CHA, Sung Jong KI, Eun Mi JEOUNG, Jun Won SHIN
  • Publication number: 20240350413
    Abstract: Lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. The present invention relates to lyophilised formulations of mRNA adsorbed onto lipid nano-emulsion particles. It particularly provides a method for lyophilisation of liquid 5 formulations of mRNA adsorbed onto lipid nano-emulsion particles under the conditions that maintain the integrity and pharmaceutical properties of resultant lyophilised formulations for the extended periods at storage temperature of about 5° C.
    Type: Application
    Filed: August 24, 2022
    Publication date: October 24, 2024
    Inventors: Swarnendu KAVIRAJ, Sanjay SINGH, Sunil RAUT, Pavan KARDILE, Ajay SINGH
  • Publication number: 20240350414
    Abstract: The present invention relates to a direct tableting auxiliary composition based on lactose powder mixed intimately with a water-soluble polyethylene glycol-polyvinyl alcohol graft copolymeras binder, crosslinked insoluble polyvinylpyrrolidone as tablet disintegrating agent and a lubricant.
    Type: Application
    Filed: August 19, 2022
    Publication date: October 24, 2024
    Inventors: Silke Gebert, Felicitas Guth, Thorsten Cech, Karl Kolter
  • Publication number: 20240350415
    Abstract: The invention relates to a new modified release oral pharmaceutical form comprising 17?-cyanomethyl-17-ß-hydroxyestra-4,9-dien-3-one (dienogest) and 17?-ethinylestradiol (ethynyl estradiol), its method of production and its medical and non-medical uses, in particular its use in contraception.
    Type: Application
    Filed: May 9, 2024
    Publication date: October 24, 2024
    Inventor: Enrico COLLI
  • Publication number: 20240350416
    Abstract: The present invention relates to a tablet composition comprising a granulate consisting of a co-precipitate on a substrate, wherein the co-precipitate comprises enzalutamide in amorphous form and a cellulosic concentration enhancing polymer. The invention further relates to the use of said composition as a medicament, particularly in the treatment of castration-resistant prostate cancer.
    Type: Application
    Filed: July 2, 2024
    Publication date: October 24, 2024
    Inventors: Sara FRADERA GELABERT, Lisardo ALVAREZ FERNANDEZ, Rohit KUMAR
  • Publication number: 20240350417
    Abstract: The invention provides an oral solid formulation comprising (a) a controlled release component comprising a core comprising levodopa, wherein the core is coated with a muco-adhesive coating and the muco-adhesive coating is externally coated with an enteric coating; and (b) an immediate release component comprising levodopa. The invention further provides a method for making and using the oral solid formulation.
    Type: Application
    Filed: June 26, 2024
    Publication date: October 24, 2024
    Applicant: Impax Laboratories, LLC
    Inventors: Ann Hsu, Liang Dong, Amy Ding, Suneel Gupta
  • Publication number: 20240350418
    Abstract: The invention relates to pharmaceutical compositions for oral administration comprising a bradykinin (BK) B2 receptor antagonist having a chemical structure according to Formula 1, or a salt or solvate thereof, wherein R is deuterium or hydrogen: Formula (1), such as (S)-N-(1-deutero-1-(3-chloro-5-fluoro-2-((2-methyl-4-(1-methyl-1H-1,2,4-triazol-5-yl)quinolin-8-yloxy)methyl)phenyl)ethyl)-2-(difluoromethoxy)acetamide. The compositions comprise the BK B2 receptor antagonist in a dissolved form in a liquid vehicle comprising propylene glycol monocaprylate, polyoxyl castor oil, and propylene glycol. Furthermore, therapeutic uses of the compositions are provided.
    Type: Application
    Filed: August 5, 2022
    Publication date: October 24, 2024
    Inventor: Christoph GIBSON
  • Publication number: 20240350419
    Abstract: The present disclosure provides a gastric resistant, enteric coated nano-silica yeast particle (YP) delivery system. The disclosure further provides methods of making and methods of using a nano-silica yeast particle delivery system.
    Type: Application
    Filed: March 21, 2024
    Publication date: October 24, 2024
    Inventors: Gary R. Ostroff, Ernesto Soto
  • Publication number: 20240350420
    Abstract: Aspects of the disclosure include fixed dose pharmaceutical compositions including a plurality of immediate release beads of oxybutynin, or pharmaceutically acceptable salt thereof, beads and a plurality of delayed-immediate release beads of pilocarpine, or pharmaceutically acceptable salt thereof and methods for treating hyperhidrosis in a subject. In some embodiments the plurality of beads are encapsulated in a size 3 capsule. In practicing methods according to certain embodiments, a variety of formulations are described to achieve a delayed-immediate release profile wherein the pilocarpine, or pharmaceutically acceptable salt thereof, is released not more than 30% in 10 minutes and not less than 85% at 45 minutes of administration of the pharmaceutical composition to the subject and oxybutynin is released soon after administration.
    Type: Application
    Filed: August 9, 2022
    Publication date: October 24, 2024
    Inventors: Stephen Wayne Andrews, Samuel Bruce Balik, John Edward Jett, Robert Michael Leming
  • Publication number: 20240350421
    Abstract: The present invention provides cationic polymeric nanoparticles, and nanoparticle formulations thereof. The invention also provides methods for preparing cationic polymeric nanoparticles, and methods of treating diseases, reducing tumor growth, and increasing uptake of a therapeutic agent by a tumor cell in a subject in need thereof.
    Type: Application
    Filed: March 15, 2024
    Publication date: October 24, 2024
    Applicant: University of Connecticut
    Inventors: Raman Bahal, Aniket Wahane, Shipra Malik, Vishal Kasina
  • Publication number: 20240350422
    Abstract: Proteinaceous nanoparticles can be used to deliver large payloads of active ingredients, which is advantageous in medicine and agriculture. However, the conjugation of hydrophobic ligands to hydrophilic nanocarriers such as plant viral nanoparticles (plant VNPs) can result in aggregation by reducing overall solubility. Provided herein are improved methods for ligand conjugations, as well as the particles prepared by these methods. The disclosed methods promote efficient bioconjugation and prevent the aggregation that accompanies conventional bioconjugation methods, thus improving the stability, homogeneity, and translational potential of plant VNP conjugates in medicine and agriculture.
    Type: Application
    Filed: July 25, 2022
    Publication date: October 24, 2024
    Inventors: Nicole F. Steinmetz, Matthew D. Shin
  • Publication number: 20240350423
    Abstract: Provided is a nanofiber sheet for healing after rotator cuff repair containing recombinant parathyroid hormone and a method of manufacturing the same. The nanofiber sheet including a composition containing recombinant parathyroid hormone therein does not cause complications, and has an excellent effect of healing of rotator cuff tears by improving tendon to bone healing when the sheet is locally fixed or attached to a suture site, specifically rotator cuff tear site or rotator cuff suture site, compared to direct systemic or local administration of recombinant parathyroid hormone.
    Type: Application
    Filed: July 20, 2023
    Publication date: October 24, 2024
    Inventors: Joo Han Oh, Hyeong Jang Jeong, Suk-Hee Park
  • Publication number: 20240350424
    Abstract: Transdermal patches including a substrate, an adhesive, and a compound formulation. The substrate is configured as a planer member with a first major face and a second major face opposite the first major face. The substrate is configured to mount to skin and includes a bottom side and a top side. The bottom side defines the first major face of the substrate and faces the skin when the substrate is mounted to the skin. The top side is opposite the bottom side and defines the second major face of the substrate. The top side includes an ornamental design. The adhesive is disposed on the bottom side of the substrate and is configured to selectively couple the substrate to the skin. The compound formulation is disposed on the bottom side of the substrate and is configured to absorb through the skin into a bloodstream below the skin.
    Type: Application
    Filed: April 22, 2024
    Publication date: October 24, 2024
    Inventors: Alexa Adams, Cleo Davis-Urman
  • Publication number: 20240350425
    Abstract: The invention provides novel compositions comprising at least two or more semifluorinated alkanes. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue, such as for use in the treatment of keratoconjunctivitis sicca (dry eye) and/or meibomian gland dysfunction and symptoms associated therewith. The invention further provides kits comprising such compositions.
    Type: Application
    Filed: April 30, 2024
    Publication date: October 24, 2024
    Inventors: Bernhard GÜNTHER, Bastian THEISINGER, Sonja THEISINGER, Dieter SCHERER
  • Publication number: 20240350426
    Abstract: The present invention relates to a bowel cleansing composition and, specifically, to a bowel cleansing composition that reduces the dosage required on the day of examination requiring bowel cleansing, thereby increasing safety. The composition is taken in divided doses the day before and on the day of the examination, and a total dosage taken on the day of the examination is 700 mL or less.
    Type: Application
    Filed: June 27, 2024
    Publication date: October 24, 2024
    Inventors: Yoon Sik Kang, Chung Yoon Shin, Hyun Suk Kang, Hyan Yee Kang
  • Publication number: 20240350427
    Abstract: The invention relates to a plant essential oil amino acid composition and a preparation method therefor. The composition of the present invention is a composition containing a plant essential oil and amino acids. The composition is obtained by mixing the plant essential oil with amino acids, the plant essential oil being selectively one or two of thymol and carvacrol. The composition of the present invention has a significantly higher melting point and lower volatility, thus significantly improving stability. When being used as an animal growth-promoting feed additive, the composition of the present invention has better palatability and lower death rate.
    Type: Application
    Filed: February 24, 2022
    Publication date: October 24, 2024
    Inventors: Xuefeng MEI, Fengyuan WANG, Jianrong WANG, Liye LU, Zaiyong ZHANG
  • Publication number: 20240350428
    Abstract: The present invention relates to the use of cannabidiol (CBD) in the treatment of focal seizures. In one embodiment the patients suffering from focal seizures are children and young adults. CBD appears particularly effective in reducing focal seizures in patients suffering with etiologies that include: Lennox-Gastaut Syndrome; Tuberous Sclerosis Complex; Dravet Syndrome; CDKL5; Neuronal ceroid lipofuscinoses (NCL); febrile infection related epilepsy syndrome (FIRES); Aicardi syndrome and brain abnormalities in comparison to other seizure types. Significantly CBD additionally is very effective in the reduction of a sub-type of focal seizures, focal seizures with impairment.
    Type: Application
    Filed: July 2, 2024
    Publication date: October 24, 2024
    Inventors: Geoffrey GUY, Stephen Wright, Orrin Devinsky
  • Publication number: 20240350429
    Abstract: An eye health supplement and methods of using the eye health supplement are disclosed.
    Type: Application
    Filed: June 28, 2024
    Publication date: October 24, 2024
    Inventor: James Stringham
  • Publication number: 20240350430
    Abstract: As a result of examination of actions of DHMBA on metastatic human prostate cancer cells (PC-3 and DU-145), it has been confirmed that the DHMBA inhibits growth of the prostate cancer cells, as well as enhances cell death and exerts a growth control action on the cancer cells, and further inhibits metastatic activity of the cancer cells. Thus, an object of the present invention is for the DHMBA to provide one that would be a valuable drug means for treatment of human prostate cancer. The present invention has a growth inhibitory action on metastatic human prostate cancer cells with an active ingredient of 3,5-dihydroxy-4-methoxybenzyl alcohol (DHMBA).
    Type: Application
    Filed: January 20, 2022
    Publication date: October 24, 2024
    Applicant: Watanabe Oyster Laboratory Co., Ltd.
    Inventor: Mitsugu WATANABE
  • Publication number: 20240350431
    Abstract: The application provides a shelf stable squaric acid ester composition (SAE). The application further provides a system and method for delivering a SAE composition to a subject to treat alopecia areata. The system comprises a storage compartment containing SAE and an excipient and an applicator unit for topical administration of the SAE composition.
    Type: Application
    Filed: August 22, 2022
    Publication date: October 24, 2024
    Inventors: Reid WALDMAN, Keith Arthur JOHNSON
  • Publication number: 20240350432
    Abstract: This disclosure relates to methods for the prevention and/or treatment of neurological adverse effects caused by viral infections in a subject. In some aspects, the methods include administration of at least one N-methyl-D-aspartic acid receptor (NMDAR) antagonist to a subject as a preventative treatment. In other aspects, the NMDAR antagonists may be used as a treatment following a viral infection or suspected viral infection.
    Type: Application
    Filed: April 19, 2024
    Publication date: October 24, 2024
    Inventors: Jill Rebecca Turner Ortinski, Linda P. Dwoskin, Bobbie Jo Mullins
  • Publication number: 20240350433
    Abstract: The present application provides pharmaceutical compositions and methods for treating diseases or disorders. The pharmaceutical composition comprises N-methyl-D-aspartate receptor modulator and ?-opioid receptor modulator. The present application also discloses formulations, dosing and administration routes for the pharmaceutical composition. Diseases can be treated by the pharmaceutical composition are also described.
    Type: Application
    Filed: August 16, 2022
    Publication date: October 24, 2024
    Inventors: John H. Krystal, Gihyun Yoon, Ismene L. Petrakis
  • Publication number: 20240350434
    Abstract: The invention concerns methods of using a ketamine dosage form in treating depression and, in particular, major depressive disorder and treatment-resistant depression, comprising administering to a patient in need thereof, a fast dissolving freeze-dried wafer solid dosage form with a matrix for rapid release and absorption of ketamine in the oral cavity of the said patient.
    Type: Application
    Filed: July 1, 2024
    Publication date: October 24, 2024
    Inventors: Yip Hang Eddy LEE, Chin Beng Stephen LIM