Abstract: Disclosed herein is a medication and health management system and method for assisting a caregiver to monitor medication adherence of a care recipient. An example system comprises a first computing device configured to store medications of a care recipient in a plurality of chambers, monitor the care recipient's adherence to a medication schedule via at least one sensor, and transmit measurement data of the at least one sensor to a computing server system. The computing server system is configured to process the received measurement data to determine whether any chamber has been opened for retrieval of the medications stored therein in accordance with the medication schedule of the care recipient, in response to determining that no chamber has not been opened, generate and transmit a notification signal to a second computing device of a caregiver of the care recipient to indicate a medication non-adherence event of the care recipient.

Abstract: A sleeved gastrojejunostomy (GJ) tube, according to the present invention, includes an inner cannula or feeding cannula that is housed in a sleeve. This arrangement allows the inner cannula to be replaced easily at the bedside by non-specialists. Traditional methods to insert the sleeved GJ tube are utilized, but in the event of feeding cannula damage or clogs, the inner cannula can be easily removed and a new one can be placed, without the need for fluoroscopy or anesthesia. The use of sleeved GJ tubes will expedite patient care, reduce complications, and decrease healthcare costs. The present invention aims to solve the common issue of a clogged GJ Tube. Clogged GJ tubes lead to emergency room visits, hospital admission, and interventional procedures. The present invention would enable exchanges of a clogged feeding cannula by providers or parents without radiation, sedation, or room time.

Abstract: A flow selector valve assembly for an enteral feeding pump system (i.e., an enteral feeding pump system including a fluid delivery set with first and second feeding tubes, an enteral feeding pump and a pinching mechanism for regulating the flow of nutrient formula or water out of the first and second feeding tubes), and a twin port adapter for use in the valve assembly. The twin port adapter includes a body configured to receive the first and second feeding tubes therein, and a feeding tube guide rotatably connected to the body and configured to secure the first and second feeding tubes within the body.

Abstract: Disclosed herein are devices and methods for initiating bonding with, and comforting and soothing, infants and babies. A soother device comprises a hollow structure, having a top portion and a bottom portion, the bottom portion comprising a suction cup element and the top portion comprising a tip portion, directly opposite from said suction cup element, said top portion being sized and configured to closely resemble a female breast; said top portion being covered by a soft cast component, the soft cast component having a comprising a nipple and areola portion directly over said tip portion. The soother device may suction to smooth surfaces or human bodies to encourage a child to self-soothe without using a mother's breast.

Abstract: The invention relates to a one-part dental adhesive composition comprising polymerizable component(s) with an acidic moiety as Component A, photo-initiator(s) as Component B1, transition metal ion component(s) as Component C, solvent(s) other than water as Component D1, a stabilizer as Component E, the stabilizer comprising a free radical moiety or being selected from anaerobic stabilizers, for use in a process of fixing a composite material to the surface of hard dental tissue, the composite material comprising a redox initiator system with an oxidizing agent and a reducing agent.

Abstract: Light emitting dental composites are fluorescing composite resins that are produced by combining one or more dental composites, such as, conventional dental composites, glass ionomer cements, resin modified glass ionomers, and/or bioactive dental composites, in either bulk fill form or flowable form, with a light energized and light emitting strontium aluminate or similar compound to form a light emitting dental composite. The light emitting dental composite makes composite resins easily identifiable when activated by a UV light source, allowing for use preferably with temporary placement, visualization, and/or removal of orthodontic attachments and restorative dentistry.

Abstract: Personal care compositions comprising non-sulfonate anionic surfactant, amphoteric surfactant, and at least two carboxylic acids or salts thereof, and wherein the compositions contain no more than 30% of the total wt % of a) and b) of sulfonated and do not contain para-chloro-meta-xylenol in an amount above 0.15% wt or salicylic acid in an amount above 0.25% wt. The compositions are intended to provide cleansing and antimicrobial benefits yet be well tolerated by skin and hair. Also provided are a dispenser and disposable wipe containing the composition, the use of the composition to provide an antimicrobial benefit to skin and/or hair, and a method for providing an antimicrobial benefit to skin and/or hair by contact with the composition.

Abstract: An active treatment formulation for applying to a substrate and a skin treatment article including the active treatment formulation applied to the substrate. The active treatment formulation includes an active agent, and a water-soluble binder. The active agent may be mixed with an absorbent powder, encapsulated by an encapsulant in a solid form, or chemically modified in a solid form.

Abstract: A manufacturing method for a solid personal care product having a three-dimensional pattern comprises a cutting process of cutting a solid base material provided on a target object such that the base material is not penetrated. In the cutting process, the base material can be cut such that a stepped portion can be formed, where the stepped portion can include a plurality of layered stairs each having a stair width in a height direction of 0.001 mm or more and 1 mm or less, and a difference in height between a topmost portion and a bottommost portion of a surface of the base material can be 1 mm or more.

Abstract: The present invention relates to filling technology for aerosol canisters. The present invention comprises in part a process for filling aerosol canisters by the steps of adding powder and liquid to the canister in separate phases before propellant.

Abstract: Matrix compositions comprising structurally diverse matrix particles (1) formed from at least five different types of primary particles distinguishable from one another due to different characteristics, shape characteristics, or both, (2) that constitute 15-50% of the matrix composition by weight, (3) that comprise or more types of particle agglomerates, (4) where at least 33% of the weight concentration of the matrix particle mixture being composed of UV-protectant metal oxide particles having a minimum particle size of over 100 nm, (5) where scanning electron microscope analysis of the composition fails to identify any significant number of discrete matrix particles of having a size of 100 nm or less, and (6) the composition exhibits one or more of sun protection factor (SPF) of at least 30, a critical wavelength of at least 370 nm, UVA/UVB ratio of at least 0.333, and a UVA1 to UV ratio of at least 0.7.

Abstract: A system for co-solubilizing actives in lipid, aqueous, and alcohol phases in a final uniform formulation is described. The lipid phase, aqueous phase, and alcohol phase are combined with a base formulation in a sequential specific manner to optimize the bioavailability of actives and release the actives uniformly upon application of the system to an epidermal layer of skin.

Abstract: Suggested are compositions comprising substituted azacycles on one hand and physiological cooling or warming agents, flavors and/or fragrances on the other for masking, enhancing and/or boosting flavors, improving soothing ability, and improving antimicrobial stability.

Abstract: The subject of the present disclosure is a process for dyeing keratinous material, in particular human hair, comprising the following steps: Application of an agent (a) to the keratinous material, wherein the agent (a) comprises: (a1) at least one organic silicon compound selected from the group of silanes having one, two or three silicon atoms, and (a2) at least one colorant compound selected from the group of pigments and/or direct dyes, application of an agent (b) to the keratinous material, wherein the agent (b) comprises: (b1) at least one film-forming polymer, and Application of an agent (c) to the keratinous material, wherein the agent (c) comprises: (c1) at least one amino-functional polyorganosiloxane and (c2) at least one polyvalent metal salt, wherein at least one of the agents (a) and (b) further comprises at least one colorant compound selected from the group of pigments and/or direct dyes.

Abstract: A method in accordance with a particular embodiment of the present invention includes increasing a concentration of a modified or unmodified saccharide within a subject's skin, applying an applicator to the subject's skin, and cooling the subject's skin via a heat-transfer surface of the applicator. The saccharide within the subject's skin can enhance a resistance of at least some cells within the subject's skin to damage associated with the cooling. A corresponding system includes the applicator, the saccharide, and an energy-delivery device. The energy-delivery device can be configured to apply ultrasound, optical, thermal, or another type of energy to the subject's skin to drive the saccharide into the subject's skin. The system can also include a penetration enhancer configured to enhance penetration of the saccharide into the subject's skin. The penetration enhancer can be applied with the saccharide or separately.

Abstract: The invention relates to the use of a rhamnolipid in a surfactant system for handwash detergents to confer to the consumer a sensorial impression of mildness on the hands.

Abstract: The present invention provides a composition for a non-therapeutic method for caring for keratin materials. The composition contains in an aqueous phase: (i) at least one cosmetic active compound selected from C-glycosides of formula (I): wherein R represents a saturated C1 to C10, alkyl radical which can optionally be substituted by at least one radical chosen from OH, COOH or COOR?2, with R?2 being a saturated C1-C4 alkyl radical, S represents a monosaccharide or a polysaccharide comprising up to 20 sugar units in pyranose and/or furanose form and of the L and/or D series, and X represents a radical chosen from the —CO—, —CH(OH)—, —CH(NH2)—, —CH(NHCH2CH2CH2OH)—, —CH(NHPh)- and —CH(CH3)— groups, the S—CH2—X bond represents a bond of an ? or ? C-anomeric nature; (ii) at least one surfactant selected from fatty acid esters of polyglycerol; and (iii) at least one surfactant selected from oxyalkylenated fatty acid esters of glycerol.

Abstract: A skincare composition that is used to prevent and heal stretch marks and scars and treat dry and flaky skin and other skin ailments is disclosed. The skincare composition is easy-to-use and contains natural and organic components. The composition includes Vitamin E, Coco butter, unrefined Shea Butter, cetyl alcohol, methylparaben, propylene glycol, propylparaben, purified water as a carrier base, sodium lauryl sulfate, stearyl alcohol, aloe vera, and an infused scent. The skincare composition can be applied to any area of the body for moisturizing and hydrating skin and enhancing healing of stretch marks and scars. The composition can be used by individuals of all ages and genders.

Abstract: Provided herein are compositions comprising succinoglycan biopolymers lacking succinyl moieties, wherein the biopolymers are heat stable or heat activated, and methods of preparing and using such biopolymers.

Abstract: A composition for use on the nails is provided. The includes a solvent system that includes at least one volatile, non-aqueous polar solvent; a water-insoluble nitrocellulose polymer; an acrylic copolymer with an acid value ranging from about 145 and about 170 mg KOH per gram; and a cellulose ester of at least one C2-C4 organic acid. Methods including those for use as a topcoat are also provided.

Abstract: A composition for use on the nails is provided, comprising a solvent system that includes at least one volatile, non-aqueous polar solvent; a water-insoluble nitrocellulose polymer; an acrylic copolymer with an acid value ranging from about 100 and about 170 mg KOH per gram; an epoxy resin; and a colorant. Methods including those for use as a color coat are also provided.

Abstract: A cosmetic composition comprises a UV filter and a polymer for enhancing SPF of the composition. The use of said polymer is enhancing SPF of cosmetic composition.

Abstract: Disclosed herein is a personal care composition. In particular, disclosed herein is a substantially anhydrous personal care composition comprising at least one non-volatile emollient oil having a boiling point of at least 215° C. at atmospheric pressure, a lipophilic material, and less than 25% antiperspirant active by weight of the composition, wherein the composition has reduced volatile silicones, and further wherein the composition is substantially free of emulsifier. The disclosed personal care composition is especially useful as an efficacious antiperspirant or deodorant stick with reduced volatile silicone content that provides parity payout and sensory benefits upon topical application to skin.

Abstract: The present invention relates to a composition for caring for and/or making up keratin materials, in particular the skin, comprising, preferably in a physiologically acceptable medium: a) at least one silicone elastomer containing carboxylic acid functions; and b) at least one copolymer based on silicone resin and on silicone of dimethiconol type. The invention also relates to a process for coating keratin materials, more particularly for making up and/or caring for keratin materials, such as the skin, characterized in that it comprises the application to keratin materials of an emulsion as defined above.

Abstract: Compositions including at least one silicone acrylate copolymer and at least one glycerolated silicone resin, as well as methods of applying such compositions to keratinous material, are provided.

Abstract: A subject matter of the present disclosure is to facilitate the permeation of a water-soluble agent into the skin. An application type body-correcting-film forming agent of the present disclosure comprises a first agent comprising a cross-linking reactive ingredient that constitutes a body-correcting film; and a second agent comprising a catalyst for cross-linking the cross-linking reactive ingredient, wherein at least one of the first agent and the second agent comprises a water-soluble agent.

Abstract: Provided are: a MG-stabilized composition which comprises mycosporine-glycine (MG) and is acidic to weakly alkaline; an MG-stabilized composition which comprises MG and at most 10 parts by weight of 4-DG; and an MAA-stabilized composition which comprises MAA and at least one selected from a base constituting a nucleic acid, a nucleoside, a glycine, and a tranexamic acid.

Abstract: A tooth paste composition comprising black cumin oil (Nigella sativa) and fluoride-doped bioactive glass, zinc oxide, and/or titanium oxide is disclosed.

Abstract: One aspect of the present invention provides an anti-obesity agent, an anti-dementia agent, a deodorant, an anti-aging agent, an anti-glycation agent, an anti-type I allergy agent, a hypotensive agent, a flavor improving agent, a muscle enhancing agent, and a bone metabolism improving agent which contain a bagasse decomposition extract as an active ingredient.

Abstract: Provided herein are cyanobacterial polysaccharide compositions. Also provided are methods of using polysaccharides for applications such as topical personal care products, cosmetics, and wrinkle reduction compositions. The disclosure also provides novel cyanobacterial compositions useful for improving the health and appearance of skin.

Abstract: Pharmaceutical compositions and methods of their administration following delivery of such compositions into a fluid-containing chamber of the body are provided. More specifically, pharmaceutical compositions mixed with reactive compositions produce a gas when brought into contact with a bodily fluid, such as that in the cochlear canal; the gas causes a fluidic movement in the chamber and also propels the disintegrating composition containing the therapeutic substance in the fluid to the apical region of the canal where the therapeutic substance contacts the tissue walls of the chamber, leading to various effects on or in cells of the tissue surrounding the fluid in that region. Methods disclosed may be used for delivery of pharmaceutical compositions to other fluid-containing chambers of the body for treatment of tissues in difficult-to-reach areas, and may be especially useful in chambers in which there is limited fluid movement.

Abstract: Disclosed are nano/micromotor devices, systems, and methods for providing payloads in the gastrointestinal system. In one aspect, a micromotor for a gastrointestinal tract includes a micromotor body including a one or more material layers to provide a structure that surrounds a hollow interior region and has an opening to an exterior of the micromotor body; one or more particles including a biocompatible metal element, the one or more particles contained in the interior region of the micromotor body; a coating coupled to the structure of the micromotor body; and a payload material, in which the micromotor is structured to move in a fluid of a gastrointestinal system based on a reaction between the one or more particles and a constituent or a condition of the fluid, such that the reaction generates bubbles that accelerate out of the opening of the micromotor body to propel the micromotor in the fluid.

Abstract: The present disclosure provides a topical formulation that possesses analgesic and anti-inflammatory activity. An aspect of the present disclosure provides a topical formulation including: (a) an essential oil in an amount ranging from 10% by wt. to 45% by wt.; (b) an active ingredient in an amount ranging from 2% by wt. to 10% by wt. and (c) an excipient. It further relates to a method of preparation of topical formulation in the form of a cream. It further relates to a method of reducing pain and inflammation in a mammal resulting from muscle strain, spasms, arthritis, and bursitis associated with sports related injury by topical administration of the formulation.

Abstract: The present application discloses a ready-to-use liquid parenteral pharmaceutical composition, that has Cetrorelix or Cetrorelix acetate. The composition also has Cetrolix or its pharmaceutically acceptable salt, ethanol, and water for injection, and a pH adjusting agent. The composition may also contain pharmaceutically acceptable excipients. The Cetrolix or Cetrolix acetate preparation can have a pH lower than 7.

Abstract: The present disclosure describes a vaginal system comprising segesterone acetate and ethinyl estradiol configured for thirteen 28-day product-use cycles that is compatible with male condoms comprising natural rubber latex, polyisoprene, or polyurethane and a method of providing birth control using the vaginal system wherein a secondary contraception is employed when the vaginal system is removed or expelled from the vagina for specified amounts of time during any of the product-use cycles.

Abstract: Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or Auris interna target areas, or via perfusion into the auris media and/or Auris interna structures.

Abstract: A constrained, wound lithium-ion battery cell with an internal fuse component that exhibits significant improvements in terms of life cycle times is provided. Disclosed herein are lithium-ion battery structures and configurations utilizing at least one thin metallized film current collector that provides safety features with low thermal runaway potential, low internal resistance, and high thermal conductivity with a simplified manner of providing external electrical conductivity simultaneously. The provision of a highly constrained and wound structure thereof unexpectedly allows for extended cycle life upon charging that is significantly improved in comparison with previous wound lithium-ion battery devices. A range of compression forces accords such results, with such forces permissible through various pathways, including winding curvature, number of windings within the cell housing, hardness of housing, and structural geometry therein.

Abstract: A medical liquid composition has protective and antioxidant properties. The composition is usable for aerial administration, for example with personal vaporizers and aerosol devices. In particular, the liquid composition does not contain propylene glycol and includes the following components: a) water 20-50% by weight b) 1,3-propanediol 20-60% by weight c) glycerol 10-30% by weight d) ethanol 0-10% by weight e) one or more protective substances preferably selected from cyclodextrins and cellulose derivatives; f) one or more antioxidants; g) optionally, a preservative, in which the sum of the weight percentages of components e), f) and g) is between 0.1% and 5% by weight.

Abstract: Disclosed is a process of preparing a coated surface, the process comprising applying a composition to the surface, wherein the composition comprises about 0.001% to about 2% w/w of a cannabinoid, at least one aqueous stabilizing agent; at least one cellulose derivative; and at least one taste-masking agent.

Abstract: Disclosed is the use of foam compositions for the delivery of therapeutics to the colon of a patient in need thereof. Also disclosed are foam compositions, and devices for delivering the composition to the colon. Additionally, methods of treating C. difficile in the colon using the foam compositions are also disclosed.

Abstract: The invention disclosed herein relates to nanoparticles containing one or more polykinase inhibitors and methods of using the same in combination with checkpoint inhibitors to treat cancer.

Abstract: The present invention is directed to peptisomes, including nanopeptisomes, which have a perfluorocarbon liquid core containing a perfluorocarbon liquid and a cargo, such as a therapeutically active agent, dispersed in the perfluorocarbon liquid, and a plurality of amphiphilic peptide molecules surrounding the perfluorocarbon liquid core, wherein the amphiphilic peptide is represented by Formula (I) HB-CL-HP wherein HB is a fluorinated hydrophobic block, such as a fluorinated hydrophobic amino acid sequence, CL is a cross-linking motif, and HP is a hydrophilic amino acid sequence. The present invention is also directed to methods of use of the amphiphilic peptides and peptisomes, such as nanopeptisomes, to deliver a cargo, such as a therapeutically active agent, to a cell, wherein the cell may be in vitro, ex vivo, or in vivo.

Abstract: Biocompatible implants comprising a cyclic lipid therapeutic agent are made using a low temperature melt extrusion process. The implants are suitable for intraocular use to treat an ocular condition.

Abstract: A composition for sustained-release injection comprising deslorelin, can prevent initial over-release by adjusting the release rate of deslorelin at a target site and can exhibit the effect of deslorelin for 1 month or more by being exposed in an amount enough to show the effect of deslorelin. Further, the microparticles can prepare microparticles that have a uniform particle size and are capable of exhibiting the effect of continuously releasing deslorelin for a long time.

Abstract: The invention relates to an amorphous solid dispersion of a quinolone compound of Formula I and process for the preparation thereof.

Abstract: A method of manufacturing a flowable and dispersible powder includes solubilizing a lipophilic substance in a terpene to form a mixture and treating the mixture to form a nanoemulsion dispersed in an aqueous solution. The aqueous solution includes at least one functional excipient. The nanoemulsion is then spray dried, thereby evaporating first the aqueous portion and then the terpene to form a dry powder formed from solid particles comprising the lipophilic substance.

Abstract: The present invention relates to a recombinant exosome containing hyaluronidase and a use thereof, and more particularly to a recombinant exosome that presents hyaluronidase on its surface and use thereof as an anticancer agent.

Abstract: A process for preparing a polymer-coated hard shell capsule can be performed. The hard shell capsule has a body and a cap. In the closed state the cap overlaps the body either in a pre-locked state or in a final-locked state. The hard shell capsule is provided in the pre-locked state and coated with a coating solution, suspension or dispersion that has at least one polymer; at least one glidant; at least one emulsifier; optionally at least one plasticizer; optionally at least one biologically active ingredient; and optionally at least one additive, different from the above. The process is used to obtain a coated, preferably only at the outer surface, hard shell capsule in the pre-locked state, wherein the coating solution, suspension or dispersion has a surface tension of at most 38 mN/m. The polymer-coated hard shell capsule obtained from the process is used for immediate, delayed or sustained release.

Abstract: Provided herein are methods and compositions for oral administration of therapeutic proteins, improved protease inhibitor preparations, methods for producing same, and compositions comprising same.

Abstract: The invention describes a core shell microcapsule wherein the capsule shell is an interfacial copolymer formed of a modified polysaccharide free radical cross-linked with a multifunctional (meth)acrylate. The polysaccharide is hydrophobically modified with an adduct containing at least one unsaturated bond. The modification imparts hydrophobic character to the polysaccharide to act as an emulsifier, driving the modified polysaccharide to an oil-water interface of an encapsulation emulsion described, and creates an active bonding site for free-radical polymerization between the polysaccharide and multifunctional (meth)acrylate, thereby forming a microcapsule shell surrounding the core material.