Abstract: A guidewire having improved torque characteristics in a proximal section of the guidewire. The proximal section has a square cross-section and a plurality of twists along the length of the proximal section. The plurality of twists have a pitch in a range from 1 to 3 twists per 1.

Abstract: A guidewire device, including a system, kit, and method of use, are disclosed. The guidewire device may include a proximal guidewire portion operably coupled to a proximal joint, which is operably coupled to an expandable portion, which is operably coupled to a distal joint, which is operably coupled to a distal tip portion. The proximal guidewire portion may include a first flexible sidewall defining a first central lumen and may include a tubular member defining a pressure lumen. The proximal joint may include a proximal hypotube. The expandable portion may include an expandable sidewall defining a second central lumen and may be fluidly coupled to the pressure lumen. The expandable portion may have a deflated configuration and an inflated configuration. The distal joint may include a distal hypotube. The distal tip portion may include a second flexible sidewall defining a third central lumen.

Abstract: Catheter placement assemblies having automatic guidewire disengagement can include a handle and seal housing assembly defining a needle lumen and guidewire lumen. Once the vasculature is accessed, the guidewire advances through the handle guidewire lumen to a target location. The needle is withdrawn proximally through the handle needle lumen with a first force. When the needle tip is withdrawn into the seal housing, the seal housing locks to the needle tip. Applying a second, greater force urges the seal housing to disengage the handle. The seal housing is retained in place by a detent and/or timing lock mechanism. As the seal housing is urged proximally, a support pin retains the guidewire in place causing the guidewire to automatically disengage the seal housing. The seal housing mitigates needle stick injuries and allows the needle and seal housing assembly to be removed, allowing for unobstructed advancement of the catheter over the guidewire.

Abstract: Various embodiments of the systems, methods and devices are provided comprising drug coated inflatable balloons and balloon catheters. Various embodiments comprise encoded data elements to identify specific balloon and/or catheter parameters or characteristics and, in some cases, to provide specific and customized inflation and deflation sequences for the balloon and catheter in use. Programmed inflation sequences are provided and may also include in some cases adaptive reaction to pressure and/or volume data that is outside of predetermined reaction window(s). The various embodiments disclosed may comprise pressure pulse periods designed to break up calcified occlusive material through a cyclically stretching of the vessel walls without damaging the vessel wall tissue.

Abstract: A device is disclosed herein, comprising: (a) at least three lumens, comprising a first lumen, a second lumen, and a third lumen, (b) a balloon inflation port in fluid communication with the first lumen, (c) a fluid delivery port in fluid communication with the second lumen, (d) a guidewire port in fluid communication with the third lumen, (e) a balloon in fluid communication with the first lumen, wherein the balloon has a first end and a second end, (f) one or more fluid delivery channels extending a length of the second lumen, and (g) one or more fluid delivery ducts extending from the one or more fluid delivery channels to an exterior surface of the second lumen, wherein the one or more fluid delivery ducts are defined only in a portion of the second lumen that is disposed adjacent the first end of the balloon.

Abstract: A method for producing a parison for a balloon catheter, a method for producing a balloon catheter, and a device for producing a parison for a balloon catheter, by which a shape of the parison can be stably formed by lowering a heating temperature of a tube. A method for producing a parison for a balloon catheter includes: fixing a pair of fixing portions of a thermoplastic tube extending along a major axis direction; heating a pair of heating portions located between the pair of fixing portions; cooling at least a part of a portion between the pair of heating portions of the tube during the heating a pair of heating portions located between the pair of fixing portions; and pulling the tube in a direction in which the pair of fixing portions are separated from each other, and stretching the pair of heating portions.

Abstract: A method for producing a parison for a balloon catheter, a method for producing a balloon catheter, and a device for producing a parison for a balloon catheter, by which a shape of the parison can be stably formed by lowering a heating temperature of a tube. A method for producing a parison for a balloon catheter includes: fixing a pair of fixing portions of a thermoplastic tube extending along a major axis direction; heating a pair of heating portions by bringing a heat source close to a surface of the tube or bringing the heat source into contact with the surface of the tube, the pair of heating portions being located between the pair of fixing portions; and pulling the tube in a direction in which the pair of fixing portions are separated from each other, and stretching the pair of heating portions.

Abstract: An angioplasty enhancement device for use with an angioplasty system including a guiding catheter, a guidewire and a balloon catheter includes an elongated shaft terminating in a guide extension catheter. A loop of flexible material is displaceable between a proximal position located within a lumen of the guide extension catheter and a distal position extending beyond the guide extension catheter for overlying an external surface of the balloon catheter. A displaceable element extending along the elongated shaft controls displacement of the loop. When the balloon catheter is inserted along the guidewire in a deflated state so as to extend across a lesion, pushing the displaceable element is effective to advance the loop from the proximal position over the external surface of the balloon catheter to the distal position so that subsequent inflation of the balloon catheter presses the loop against the lesion.

Abstract: This disclosure provides compositions, devices, systems, and methods that reduce the likelihood, amount, or level of cellular deposition (and associated blockage and/or failure) of implantable medical devices, such as central nervous system implants. Embodiments involve use of inhibitor(s) of one or more of TLR-4, TNF-?, IL-1?, or IL-6, for instance, to prevent, reduce, or reverse activation of astrocyte and/or glia cells, and/or to prevent, reduce, or reverse attachment of such cells to the surface of a medical device in contact with a biological fluid, such as cerebrospinal fluid.

Abstract: A esophagus medicine applying device of the present invention includes a shell, an applying shell, an assembling mechanism, a return mechanism, a power supply mechanism, an arc cover, a camera, a transparent cover and an end cover; the return mechanism is arranged within the shell, the assembling mechanism is arranged on the applying shell, and the power supply mechanism is arranged on the shell; the arc cover is connected to the applying shell through threads, the camera is fixedly connected to the interior of the arc cover, and the transparent cover is fixedly connected to the arc cover; one end of the shell is in threaded connection with the end cover, a partition plate is fixedly connected to the interior of the shell, an input pipe is fixedly connected to the interior of the shell, and an output pump is fixedly connected to the partition plate.

Abstract: A hand-held underarm spray delivery device, comprising: a container for containing medically active ingredient; an actuatable pump connected to the container and comprising a spray dispensing orifice with a spray axis, wherein the pump is adapted for upon actuation releasing a spray comprising the medically active ingredient through said orifice along the spray axis; a housing comprising a first part, a second part, and a flexible shroud attached to the first and the second part, wherein the pump is arranged within the housing, and wherein the first part and/or the second part is provided with an opening aligned with the spray dispensing orifice for allowing spray released through the dispensing orifice to pass through, wherein the second part is rotatable about an axis of rotation relative to the first part between an open position in which spray can pass out of the housing, and a closed position in which spray is prevented from passing out of the housing.

Abstract: A device and methods for producing microneedles includes a microneedle female mold, a vacuum chamber, a filling mechanism and an evacuation mechanism. The vacuum chamber includes a feeding cavity, a filling cavity and a discharging cavity, which are independent of one another. The feeding cavity receives the microneedle female mold therein in non-negative pressure state, and the evacuation mechanism evacuates the feeding cavity that has received the microneedle female mold therein. The filling cavity receives, in negative pressure state, the microneedle female mold transported from the feeding cavity in negative pressure state. The discharging cavity receives, in negative pressure state, the microneedle female mold transported from the filling cavity in negative pressure state and to undergo vacuum destruction after the microneedle female mold is received therein. The device and methods more efficiently produces microneedles in large batches and ensuring formation quality of the produced microneedles.

Abstract: A microneedle patch includes a substrate and a plurality of microneedles disposed on the substrate, each of the plurality of microneedles including: (i) one or more polymers dissolvable in human skin layer, (ii) a plurality of lipid nanoparticles, and (iii) a nucleic acid drug encapsulated by the plurality of lipid nanoparticles; each of the plurality of microneedles being defined with a tip end portion that enables dermal penetration, and the microneedle patch being adapted to be stored at room temperature.

Abstract: A microneedle system for use with a micro-endoscope having a suction tubing coupled to a camera scope portion, the system including a needle assembly comprising: a microneedle defining a tip and a base; a support member having a distal end and a proximal end, the microneedle base mounted on the distal end of the support member, and flexible tubing, the proximal end of the support member affixed to the flexible tubing; wherein the suction tubing defines an interior lumen, a bend at the distal end portion thereof and a distal edge that is non-orthogonal to the linear axis of the tubing, such that the distal end portion is visible within the camera field of view, and wherein the needle assembly is received within the interior lumen of the suction tubing such that the microneedle is extendable from the distal end of the suction tubing and visible within the camera field of view.

Abstract: This invention marks a significant innovation in the skincare and body care industry, being the first to harness methods for infusing skincare and body care products with a range of sound frequencies. While it prominently features the use of sound and solfeggio frequencies, the methodology is versatile, accommodating a broad spectrum of sound frequencies. Sound frequency infusion is an approach not replicated by any other entity in the market. This process, distinct from conventional frequency infusion methods intended for oral consumption, involves state-of-the-art techniques such as sound emission from playback devices and/or resonation within frequency tuned sound bowls. By being the first in the market to apply such a unique vibrational therapy method in skincare and body care products, ‘Prism Harmonics’ not only elevates daily skincare and body care routines but also introduces novel concepts in vibrational therapy application.

Abstract: An introducer sheath including a valve hub and an elongate shaft extending from the valve hub. The valve hub defines a main port and a side port. The main port includes a hub body, a seal disposed within the hub body, a main port lid attached to the hub body, a tightening port hub attached to the main port lid, a compressible seal disposed within a lumen of the tightening port hub, a pusher at least partially positioned within the lumen of the tightening port hub and slidably movable relative thereto, and a lock nut surrounding the pusher. The lock nut is threadably engaged with the tightening port hub such that rotation of the lock nut moves the pusher axially toward and/or away from the compressible seal.

Abstract: The present disclosure relates to a connector for an infusion set. The connector comprises a body and at least one arm connected to the body which is configured to couple with a base of an infusion set; wherein the body has a first portion and a second portion which are configured to be removably and replaceably coupled together; and wherein each portion has a fluid delivery conduit, the conduits being configured to allow fluidic communication of the connector with at least two independent fluid sources. Also disclosed is an infusion set.

Abstract: Some embodiments of percutaneous ventricular assist devices have a two-part design that includes a housing component and a separately deployable rotatable inner catheter component. The housing component can include an expandable pump housing. The inner catheter can include an expandable pump impeller and an associated flexible drive shaft. The drive shaft can be coupled to a motor located external to the patient. The motor can rotate the drive shaft to spin the pump impeller inside of the pump housing, causing blood to be pumped within the patient. In some embodiments, the pump impeller is inflatable or self-expandable. The two-part percutaneous ventricular assist devices with inflatable or self-expandable pump impellers are designed to have very small delivery profiles. Accordingly, various deployment modalities, including radial artery deployment, are practicable using the two-part percutaneous ventricular assist devices described herein.

Abstract: Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.

Abstract: An implantable medical lead comprises a conductive flexible circuit board, wherein the conductive flexible circuit board is divided into a stimulation segment, an intermediate segment and a connection segment; an outer surface of the stimulation segment of the conductive flexible circuit board is provided with a plurality of stimulation contacts, and an outer surface of the connection segment of the conductive flexible circuit board is provided with a plurality of first connection contacts; the outer surface of the stimulation segment of the conductive flexible circuit board is provided with collection contacts, the conductive flexible circuit board is provided with second connection contacts, a plurality of collection contact conductive layers are embedded in the conductive flexible circuit board, and the second connection contacts are electrically connected to the collection contacts through the collection contact conductive layers.

Abstract: Devices and methods of use for introduction and implantation of an electrode as part of a minimally invasive technique. A system includes an introducer tool including a dilator portion, a carrier portion and a release mechanism, the dilator portion selectively engageable with the carrier portion. The system further includes a lead including a lead body and an electrode structure, the electrode structure including an active side with an electrode disposed thereon, and an inactive side with an element disposed thereon. The introducer tool is configured to be temporarily inserted into a patient over a guidewire, and a portion of the release mechanism is selectively engageable with the element of the electrode structure to retain the electrode structure to the introducer tool.

Abstract: A directional tunnel device for a subcutaneous implantable device is provided. The tunnel device includes an elongate outer sleeve having an open proximal end and an open distal end. An elongate outer trough has a trough proximal end, a trough distal end, and a concave cradle extending between the trough proximal end and the trough distal end. The outer trough is sized to slidingly fit inside outer sleeve such that the outer sleeve is slidable externally along the outer trough. An inner glide rests in the cradle. The inner glide includes an inner trough, a guide arm connected to a distal end of the inner trough, and a pivot arm connected to a distal end of the guide arm.

Abstract: The present disclosure is directed to neural interface devices and methods that accesses the subarachnoid space to enable minimally invasive modulation and recording of neural structures. Exemplary embodiments may comprise an implantable pulse generator and a microelectrode catheter. In particular embodiments, the microelectrode catheter comprises one or more stimulating and recording electrodes. Exemplary embodiments may also include methods comprising performing a lumbar puncture to access the spinal subarachnoid space and advancing microcatheter through the spinal subarachnoid space.

Abstract: A cosmetic device includes a head, a grip, a treatment selection part, and a display. The grip is attached such that its distal end is coupled to the head body, with the head and grip being T-shaped as a whole. The head includes a first distal end and a second distal end. The first distal end is applied to a skin of a user, and includes a skin condition measuring part that measures the skin condition of the user. The second distal end is applied to the skin of the user, and includes an action part that electrically or mechanically acts on the skin. The treatment selection part diagnoses the measured skin condition and selects a corresponding treatment program. The display displays the selected treatment. The treatment selection part and the display are each provided at either one of the head and the grip.

Abstract: A transcorneal electrical stimulation (TES) apparatus for treating brain diseases is provided. The apparatus includes an eye-contacting interface with at least one active electrode, an inactive reference electrode, and a current source. Both the active and reference electrodes are electrically connected to the current source, facilitating transcorneal electrical stimulation for various applications.

Abstract: Proposed is a method for controlling vagus nerve stimulation to stimulate the vagus nerves in both ears, in which one or more of intensity (V), a frequency (F), and a pulse width (PW) of electrical stimulation that is applied to both vagus nerves are separately controlled, and the electrical stimulation that is applied to the vagus nerves in both ears is controlled such that a difference of E expressed by the following [Equation 1] becomes 5,000 or more, [Equation 1] E=V2×F×PW. In this case, as units in the equation 1, the intensity is V, the frequency is Hz, and the pulse width is us. There is an excellent effect that not only can improve an effect of vagus nerve stimulation, but also can activate the brain connected to the vagus nerve when stimulating the vagus nerve through electrodes being in contact with ears.

Abstract: The present disclosure provides methods and systems for treating affective disorders such as depression and/or anxiety and/or related disorders. Closed-loop therapy is performed with a neurostimulator that records electroencephalographic signals from neural activity associated with symptoms of a neuropsychiatric disorder and delivers electrical stimulation when pre-specified patterns of neural activity associated with a symptom are detected. Methods are also disclosed for mapping the brain of a patient to optimize placement of electrodes for detecting neural activity associated with symptoms of a neuropsychiatric disorder and to optimize placement of electrodes for delivery of electrical stimulation. Methods of monitoring and evaluating the effects of electrical stimulation on clinical symptoms and status are also provided.

Abstract: A system and method are provided to improve physiological function in a patient having a spinal cord lesion or quantify the state of the spinal cord and thus the state of progression of the spinal cord lesion. The system and method use spinal electrophysiological data, such as ECAPs, to determine a patient's physiological state and direct delivery of spinal cord stimulation in response to the determination of the patient's physiological state to achieve a therapeutic effect.

Abstract: The present disclosure generally relates to the field of treatment of neurological disease, and in particular to devices and methods for treating neurological diseases based on adaptive stimulation and to methods for controlling such devices.

Abstract: In one example, the disclosure describes a method comprising receiving, by processing circuitry, information indicative of one or more evoked compound action potential (ECAP) signals. The one or more ECAP signals are sensed by at least one electrode carried by a medical lead. The processing circuitry determining that at least one characteristic value of the one or more ECAP signals is outside of an expected range. Responsive to determining that the at least one characteristic value of the one or more ECAP signals is outside of the expected range, the processing circuitry performs a lead integrity test for the medical lead.

Abstract: Techniques are disclosed for using a cardiac signal sensed via a plurality of electrodes disposed on one or more leads implanted within an epidural space of a patient to control spinal cord stimulation (SCS) therapy. In one example, an implantable medical device (IMD) senses an electrical signal via a plurality of electrodes disposed on one or more leads implanted within an epidural space of a patient. Processing circuitry determines, from the electrical signal, one or more cardiac features indicative of activity of a heart of the patient. The processing circuitry controls, based on the one or more cardiac features, delivery of SCS therapy to the patient.

Abstract: Methods and systems for seamless adjustment of treatment are disclosed. A determination can be made as to whether to intervene with a patient's treatment based on data obtained from implantable electrodes and/or non-implantable electrodes. The data from non-implantable electrodes have a correction factor applied to adjust for less accuracy compared to data acquired from implantable electrodes.

Abstract: An extra-cardiovascular medical device is configured to select a capacitor configuration from a capacitor array and deliver a low voltage, pacing pulse by discharging the selected capacitor configuration across an extra-cardiovascular pacing electrode vector. In some examples, the medical device is configured to determine the capacitor configuration based on a measured impedance of the extra-cardiovascular pacing electrode vector.

Abstract: A system for controlled sympathectomy procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure is disclosed.

Abstract: An active medical device has a feedthrough comprising a ferrule sealed to a ceramic insulator supporting a short terminal pin and a long terminal pin that are connected to electronic components in the device housing. A silicone insulator residing in the ferrule abutting the ceramic insulator has first and second openings that house first and second metallic housings nesting respective coil springs. The metallic housings connected to the respective short and long terminal pins are axially aligned in the silicon insulator. A lead connector connected to a strain-relief for a lead supports a co-axial lead pin having electrically isolated center and circumferential outer conductors. When the lead connector/strain-relief subassembly is connected to the feedthrough, the center and circumferential conductors of the lead pin are electrically connected to the coil springs nested in the first and second metallic housings connected to the short and long terminal pins of the feedthrough.

Abstract: A method of manufacturing an implantable medical device having electrical components disposed within a cavity of a housing. The method comprises heating a gel filler material to a liquid, flowable state, depositing the gel filler material in the liquid, flowable state into the cavity to substantially encapsulate the electrical components within the gel filler material; and allowing the gel filler material to cool to a semi-solid state.

Abstract: The invention relates to a method and system for treating an area with radio frequency radiation with a resonant frequency and modulation function calibrated to destroy harmful pathogens, such as bacteria, viruses or other germs. According to the present invention, transmitters are used to neutralize harmful pathogens within a space, and may be used with corresponding receivers are used to verify the functional performance of the transmitters, and to create a data stream so that human occupants of the spaces so being treated can be assured that the areas they occupy have been so treated.

Abstract: Embodiments include a system comprising a non-thermal plasma (NTP) device including a handpiece configured to generate NTP at a treatment site comprising an intraoral region. A sleeve is configured to removably couple to a distal region of the handpiece.

Abstract: An analog resonator system for generating electromagnetic energy includes a capacitor assembly and a power transformer for supplying electrical potential to the capacitor assembly. The capacitor assembly includes a first capacitor plate, a second capacitor plate and a dielectric insulator plate. The capacitor plates are formed from a first conductive metal material and from a second conductive metal material dissimilar from the first conductive metal material. An analog PEMF therapy device includes the analog resonator system, a bulb electrically connected between the capacitor assembly and the power transformer, and a base electrically connected between the capacitor assembly and the power transformer.

Abstract: A method and system for individualized target localization for transcranial magnetic stimulation (TMS) in treating depression. The system acquires resting-state functional MRI (R-fMRI) brain imaging data from subjects in both a major depressive disorder (MDD) group and a matching normal control group, followed by data preprocessing. Taking the spherical subgenual anterior cingulate cortex (sgACC) as the seed point, functional connectivity calculations are performed for each subject, and sgACC functional connectivity maps within the mask of the dorsolateral prefrontal cortex (DLPFC) region are extracted. A two-sample t-test is conducted on the sgACC functional connectivity maps of the two groups to identify clusters within the DLPFC mask that show significant differences between the two groups, which are used as group-level localization targets.

Abstract: The present invention provides a method and apparatus for pain relief. In one embodiment, the present invention provides a passive electromagnetic apparatus to relieve pain using established electrochemical principles in conjunction with alloy composition elements and designs having electromagnetic characteristics to attract, transport and dissipate electrochemical ions in nerve cell bodies to relieve pain when applied on or near a painful area.

Abstract: BioElectric Therapy is a therapeutic program that utilizes electrical stimulation to promote healing, alleviate pain, and improve overall well-being. This abstract provides an overview of the program, highlighting its principles, techniques, and potential benefits. The efficacy of BioElectric Therapy is supported by scientific research, as well as first-hand experiences and testimonials from clients who have undergone the program. The abstract concludes by emphasizing the potential of BioElectric Therapy as a valuable treatment option for individuals seeking relief from chronic pain, improved mental health, and accelerated healing processes.

Abstract: Combined methods for treating a patient using time-varying magnetic field are described. The treatment methods combine various approaches for aesthetic treatment. The methods are focused on enhancing a visual appearance of the patient.

Abstract: The present disclosure provides an intelligent photo-biological treatment device for eyes and eye training method.

Abstract: A near-infrared (NIR) light therapy device having at least one NIR light source and a waveguide having i) a NIR light input surface and ii) a NIR light emitting surface. The waveguide includes a lens feature forming the NIR light input surface. The lens feature is configured to at least substantially collimate treatment NIR light from the at least one NIR light source and convey substantially collimated light in a first direction through the waveguide. The waveguide also includes a plurality of extractive surfaces on a surface of the waveguide that is configured to reflect the substantially collimated light through the light emitting surface to a subject. The plurality of extractive surfaces is also configured to create a substantially uniform NIR light output across the light emitting surface.

Abstract: A system for delivering light therapy, the system comprising: (a) a first light source for emitting continuous light; and (b) a second light source for emitting pulsed light having a frequency of between 40 and 200 Hz in integer multiples of 20 Hz.

Abstract: In an exemplary embodiment, a phototherapy device capable of delivering natural sunlight to a subject is provided. The phototherapy device includes a bassinet configured to hold a subject for treatment, an angular non-domed enclosure having an angled front wall and made from a flexible, transparent material connected to the incubator to create a space therein, and in some embodiments a support for supporting the bassinet. The enclosure formed around the bassinet allows visible sunlight to enter the enclosure in any direction for treating the subject while partially filtering ultraviolet (UV) and infrared radiation (IR) rays of the visible sunlight from entering the device, and is configured to direct incident IR rays out of the enclosure such that there is no build-up of heat that would harm the subject resting therein.

Abstract: An apparatus for providing treatment to at least one tissue includes a distal balloon, a proximal balloon, and at least one intermediate balloon positioned between the distal balloon and the proximal balloon and inflatable independently from the distal and proximal balloons. A source lumen is positioned within at least the intermediate balloon receives a radiation source to treat target tissue adjacent the intermediate balloon.

Abstract: A method for treating a cancerous tumor, by implanting in the cancerous tumor at least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon of at least 10 Mega becquerel (MBq) hour, per centimeter length. Optionally, the sources are implanted in an array of sources, each source separated from its neighboring sources in the array by not more than 4.5 millimeters.

Abstract: A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 11.6 MBq hour, per centimeter length.