Abstract: Disclosed is a system of non-invasive optical rotation angle sensing polarimeter for aqueous glucose concentration measurement. A linear polarization angle is set at 45° along propagation axis, the polarized beam transmitting aqueous humor and the polarized beam splitter whose polarization directions are orthogonal at 0° and 90° of rotation in the directions of propagation axes; difference of intensities of the orthogonal polarization components is measured in a balanced detector configuration able to obtain Stokes vector component S1 which relates to the optical rotation angle and aqueous glucose concentration under common noise rejection mode, the sum of the intensities to normalize S1 enables reduction of the optical intensity fluctuation noise too.

Abstract: A protection sheet for a body attachment device according to the present invention relates to a protection sheet for a body attachment device, which is detachably coupled to an adhesive layer to cover and protect the adhesive layer of the body attachment device, which is attached to the skin of a user, the protection sheet comprising: a first section and a second section partitioned by a cutting line which is disposed inside an outer rim of the protection sheet; and an adhesive part provided on at least one of the first section and the second section so that a separation member by which the protection sheet can be pulled in a direction in which the protection sheet can be separated from the adhesive layer can be attached.

Abstract: Methods, devices, and systems may use a kinetic model to determine physiological parameters related to the kinetics of red blood cell glycation, elimination, and generation. Such physiological parameters can be used, for example, to determine a more reliable calculated HbA1c. In another example, a method may comprise: receiving a plurality of glucose levels over a time period; receiving a glycated hemoglobin (HbA1c) level corresponding to an end of the time period; determining at least one physiological parameter selected from the group consisting of: a red blood cell glycation rate constant (kgly), a red blood cell generation rate constant (kgen), a red blood cell elimination constant (kage), and an apparent glycation constant (K), based on (1) the plurality of glucose levels and (2) the HbA1c level; and adjusting a glucose level target based on the at least one physiological parameter.

Abstract: An analyte sensor device includes a housing, a sensor, and a printed circuit board assembly (PCBA) within the housing and including a circuit and a first plurality of contacts. The sensor includes a proximal end within the housing and a distal end outside of the housing. The proximal end includes a second plurality of contacts electrically connected to the first plurality of contacts on the PCBA. The distal end includes one or more electrodes configured to measure a concentration level of an analyte in a body of a user. The circuit is operable to detect electrical connection between the first plurality of contacts and the second plurality of contacts within the housing while the distal end of the sensor is outside the body of the user or a fluid.

Abstract: Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Abstract: An electronic circuit configured to operate an analyte sensor, such as a glucose sensor, the circuit having at least a first and a second electrical connection configured to be connected to a first and a second electrode of the analyte sensor respectively. The electronic circuit has a voltage source and a common potential conductor section electrically provided on a potential of a pole of the voltage source, wherein, with the voltage source, an electric potential different from the potential of the common potential conductor section can be provided to the first electrical connection, and wherein the second electrical connection is connected to the common potential conductor section through one or more common potential connection paths wherein none of the common potential connection paths connects the second electrical connection to the common potential conductor section through fewer than three or more series-connected electronic components.

Abstract: A blood detection method and a blood detection device are disclosed. When a count number of platelet in a blood sample is less than a predetermined value, a detection solution of the blood sample is prepared. A cell statistical amount of the detection solution of the blood sample is increased to obtain the platelet detection result. The cell statistics amount of the detection solution of the blood sample may be increased in an impedance detection area to perform PLT-I detection, or in an RET detection area; or performing both of RET detection and PLT-O detection simultaneously. Thus, the accuracy of platelet detection can be improved when the number of platelets in the blood sample is low.

Abstract: The present disclosure provides methods, systems, and devices for non-invasively measuring a level of an analyte in a user using Stimulated Raman Scattering. A device can include a Raman pump source that emits pump light toward a tissue at a pump wavelength and a Stokes source that emits Stokes light toward the tissue at one or more Stokes wavelengths. The device can further include one or more mirrors and lenses. The device can further include a beam controller that controls the one or more mirrors and the one or more lenses to target the pump light emitted by the Raman pump source and the Stokes light emitted by the Stokes source at an optimal target location. The device can further include a photodetector that measures light that emanates from the tissue. The device can further include a processor that estimates the level of the analyte in the user.

Abstract: An apparatus including a housing, circuitry at least partially within the housing, a power source including first and second terminals, first and second electrically conductive leads, and a coupler. The first and second electrically conductive leads may be connected electrically to the first and second terminals, respectively, of the power source. The coupler may be attached to the power source. At least a portion of the housing may extend into the coupler. The coupler may include one or more openings through which the first and second electrically conductive leads are capable of being laser welded to first and second contact pads, respectively, of the circuitry. A method for manufacturing the apparatus may include laser welding the first and second electrically conductive leads to the first and second contact pads, respectively, of the circuitry through the one or more openings of the coupler.

Abstract: A system of generating a blood oxygen saturation map of a patient's gingiva may include an intraoral scanner, a display, a processor, and memory comprising instructions. The instructions when executed by the processor may cause the system to generate, using the intraoral scanner, 3D scan data of a first portion of a dentition of a patient including a first portion of a gingiva of the patient. The system may generate, using the intraoral scanner, blood oxygen saturation data for the first portion of the dentition of the patient including the first portion of the gingiva of the patient and map the blood oxygen saturation data of the first portion of the gingiva of the patient to the 3D scan data. The system may display, on the display, the 3D model of the dentition of the patient with feedback indicating locations of blood oxygen saturation below a threshold.

Abstract: Provided is a system for estimating oxygen saturation by using a photoplethysmography (PPG) signal sensing ring.

Abstract: A probe unit is a probe unit used to measure hemoglobin dynamics inside a subject, and the probe unit includes a main body having flexibility, a first probe attached to the main body and having a first face from which a first light emitting portion for irradiating the subject with light is exposed, a second probe attached to the main body to face the first probe and having a second face from which a first light incidence portion for detecting light propagated inside the subject is exposed, a first light shielding member having light shielding properties, containing an elastic material, and attached to the first face to surround an emission axis of the first light emitting portion, and a second light shielding member having light shielding properties, containing an elastic material, and attached to the second face to surround an incidence axis of the first light incidence portion.

Abstract: A separation syringe assembly comprising a syringe barrel assembly and a plunger assembly, the syringe barrel assembly having an outer wall in the form of a hollow cylinder, and a cap provided at the distal end of the syringe barrel assembly; the plunger assembly providing a first plunger and a second plunger, the first plunger is a hollow barrel enclosed to form a container, the second plunger provides a cylindrical body with an open distal end and concentrically aligned outside of the first plunger. The separation syringe is configured to be rotated about the longitudinal axis and thereby separate the contents within the hollow cylinder of the syringe barrel assembly into at least two concentric annular layers.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: A flow restriction device may include a male luer connector portion and a female luer connector portion. The male luer connector portion can define a first lumen and the female luer connector portion can define a second lumen. A flexible tubing preferably provides fluid communication between the first lumen and second lumen. The flexible tubing can be helically wound around a solid core, and the flexible tubing can be helically wound within a hollow chamber. The flexible tubing is configured to increase flow resistance through the tubing to reduce shear stress on the fluid, thereby decreasing the incidence of hemolysis.

Abstract: Blood sample optimization systems and methods are described that reduce or eliminate contaminates in collected blood samples, which in turn reduces or eliminates false positive readings in blood cultures or other testing of collected blood samples. A blood sample optimization system can include a blood sequestration device located between a patient needle and a sample needle. The blood sequestration device can include a sequestration chamber for sequestering an initial, potentially contaminated aliquot of blood, and may further include a sampling channel that bypasses the sequestration chamber to convey likely uncontaminated blood between the patient needle and the sample needle after the initial aliquot of blood is sequestered in the sequestration chamber.

Abstract: Multi-modal systems, for voice-based mental health assessment with emotion stimulation, comprising: a task construction module to construct tasks for capturing acoustic, linguistic, and affective characteristics of speech of a user; a stimulus output module comprising stimuli, basis the constructed tasks, to be presented to a user in order to elicit a trigger of one or more types of user behaviour, the triggers being in the form on input responses; response intake module to present, to a user, the stimuli, and, in response, receive corresponding responses in one or more formats from responses; an autoencoder to define relationship/s, using the fused features, between: an audio modality to output extracted high-level text features; and a text modality to output extracted high-level audio features; the autoencoder to receive extracted high-level text and audio features, in parallel, to output a shared representation feature data set for emotion classification correlative to the mental health assessment.

Abstract: A transportation vehicle, a physiological state detection device and a physiological state detection method are provided. The transportation vehicle configured for using the physiological state detection device includes a device casing module, a signal control module, an image capturing module and an information providing module. The image capturing module and the information providing module are disposed inside the device casing module and electrically connected to the signal control module. When the image capturing module is optionally configured to be used, the image capturing module can be allowed to be configured through the signal control module to continuously or discontinuously capture a plurality of facial images of a driver. When the information providing module is optionally configured to be used, the information providing module can be allowed to be configured through the signal control module to present a physiological state signal corresponding to the facial images.

Abstract: A method for predicting a severity and appearance of renal obstruction, including receiving, via processing circuitry, a plurality of medical images corresponding to a kidney of a patient, identifying, the kidney in the plurality of medical images, selecting, at least one relevant image from the plurality of medical images based on a relationship to renal function, standardizing the at least one relevant image, determining, via a deep learning model at least one risk score based on the at least one relevant image, and determining, a final ultrasound-based risk score based on the at least one risk score, wherein the final ultrasound-based risk score is a determination of renal obstruction and/or a probability of renal obstruction.

Abstract: An oxygen measurement device constituting an oxygen measurement system includes a urethral catheter and an oxygen sensor main body. The urethral catheter has a shaft in which a urethral catheter lumen that enables circulation of urine flowed in via a urethral catheter port from inside a bladder is formed; and has a hub in which a urine lumen that is provided at a proximal end of the shaft and communicates with the urethral catheter lumen is formed. The oxygen sensor main body is provided on the hub in a manner capable of being brought into contact with urine circulating in the urine lumen, and detects oxygen in the urine. The shaft also includes a gas permeation suppressing part that suppresses gas permeation into the urethral catheter lumen by way of the shaft.

Abstract: A wearable tensiometer integrates patient-worn muscle tissue tensiometery and motion tracking to enable real-time energy measurement for an individual's full gait cycle outside of a laboratory environment.

Abstract: A device for improved quantification of hypertonus is disclosed. The device is configured for grasping a limb segment of a patient and includes a force sensor module for continuously measuring a force generated by rotating the limb segment of the patient between a first position and a second position, at least one IMU, and at least one processor that generates at least one clinically relevant measure of response based at least on force data from the force sensor module and inertial data from the IMU.

Abstract: A computing system and method that can be used for a video conferencing system including a graphical user interface having a virtual whiteboard user interface that is responsive to inputs from multiple attendees of a video conference. In particular, the state of an application tool such as a camera, visual note indicator, web link, pen/pencil tool, highlighter tool, or other application tool executing or otherwise represented within the multi-user interaction whiteboard can respond and change in real-time as multiple attendees of the video conference interact with the virtual whiteboard user interface. The systems and methods of the present disclosure allow for a multi-user interaction whiteboard to offer various tools for the video conferencing system to facilitate interactions by multiple attendees within the graphical user interface.

Abstract: A sensor for recording bioelectrical signals directly from hairy skin regardless of the amount or density of hair is fabricated using a polymer with an electrically conductive filler. The sensors have a stemmed conical microstructure array (CMSA) on the sensor surface that interfaces with and adheres to the skin between the hairs. The CMSA sensors are fabricated using a viscosity-controlled dip-pull process (VCDP), including dipping a mold into an electrically conductive polymer precursor having a selected viscosity that is optimized for formation of the conical microstructures upon a controlled pulling of the mold from the polymer precursor.

Abstract: A method includes displaying together plots of beats that are each associated with a first beat classification, selecting at least one of the plots of the beats to identify at least one selected beat, creating a subgroup of the beats based on a comparison of the beats associated with the first beat classification relative to the at least one selected beat, and reclassifying the beats in the subgroup to a second beat classification.

Abstract: According to an embodiment of the present disclosure, there are disclosed a method, computer program and device for measuring a continuous body condition based on deep learning, which are performed by a computing device. The method includes: acquiring electrocardiogram data; and inferring a body condition corresponding to the occurrence or progress of a disease in a subject, whose electrocardiogram data was measured, based on the electrocardiogram data by using a pre-trained neural network model. The neural network model has been trained based on at least one of a first feature related to biological information representing a body characteristic having a correlation with the disease and a second feature related to pathological information reflecting the degree of progress of the disease therein.

Abstract: Systems of methods involve receiving a package of data comprising strips of electrocardiogram (ECG) data and metadata; displaying, on a user interface, at least some of the strips of ECG data, including a strip of ECG data associated with an initial maximum heart rate; and overriding the initial maximum heart rate in response to selecting a strip of ECG data associated a lower maximum heart rate.

Abstract: A system for predicting an origin position of a ventricular arrhythmia (VA), an electronic device and a storage medium are disclosed. The system includes an acquisition module (100) for acquiring a body-surface electrocardiogram (ECG) to be subjected to prediction; and a prediction module (200) for performing stage-wise prediction on the body-surface ECG using at least two stages of pre-trained prediction models, thereby obtaining prediction results corresponding to the origin position of the VA. The storage medium stores therein a computer program, which, when executed by a processor, implements the steps of: acquiring a body-surface ECG to be subjected to prediction (S100); and performing stage-wise prediction on the body-surface ECG using at least two stages of pre-trained prediction models, thereby obtaining prediction results corresponding to the origin position of the VA (S200). The electronic device includes the system and/or the storage medium.

Abstract: A method includes receiving cardiac signals from multiple locations within a ventricle of a heart of a patient. The received signals are compared with reference signals indicative of an arrhythmia. Based on the comparison, a direction is calculated, towards a location that may demonstrate an increased correlation between the received signals and the reference signals. The direction is indicated to a user.

Abstract: A biological information recording device as an example of the present disclosure includes: an acquisition processor configured to acquire biological information on a subject, which is detected by a biological information sensor, and a recording processor configured to record the biological information acquired by the acquisition processor, and to further record, when a designation operation that designates a task to be carried out by the subject is performed by an observer who observes the subject during recording of the biological information, the task in association with the biological information.

Abstract: An apparatus for performing an activity based on a sympathetic nervous system (SNS) response to a stimulus includes an electrode configured to contact a person undergoing the stimulus. The apparatus also includes a processing unit having an algorithm programmed by machine-learning and configured to: (i) receive at least one of electrocardiogram (ECG) signals or electrodermal activity (EDA) signals from the electrode; (ii) analyze at least one of skin sympathetic nerve activity (SKNA) signals derived from the ECG signals or the EDA signals to measure the SNS response and provide an SNS response measurement; and (iii) transmit an SNS response measurement signal conveying the SNS response measurement to initiate the activity. The apparatus also includes an activity device configured to perform the activity in response to the SNS response measurement signal.

Abstract: Systems and methods include receiving at least one data entry associated with a user from a user device, determining historical user data based on the at least one data entry, receiving a request to initiate a memory recall session from the user device, determining interactive(s) specific to the user based on at least a portion of the historical user data, transmitting the interactive(s), causing the user device to display the interactive(s) during the memory recall session, receiving response(s) of the user to the interactive(s), determining an interactive result specific to the user based on the response(s), determining supplemental data associated with the response(s), determining a neurocognitive result based on the interactive result and the supplemental data, and transmitting the neurocognitive result for display via a graphical user interface of the user device.

Abstract: A cognitive function evaluation method includes executing an inspection based on a TMT for urging a subject to connect passing points by a line, extracting, from the obtained inspection data, first inspection value data related to a residence time during which a line drawn by the subject sequentially tracking the passing points stagnates at a first passing point that is any one of the passing points from when the drawn line reaches the first passing point until when the drawn line starts moving to a second passing point, and second inspection value data related to a movement time required from when the drawn line starts moving from the first passing point until when the drawn line reaches the second passing point; and evaluating a cognitive function of the subject based on the first inspection value data and the second inspection value data which have been extracted.

Abstract: The present disclosure addresses the problem of providing a method for evaluating the state of skin by employing a simple measurement measure, for example a method for evaluating the degree of aging of skin, the elasticity of skin, the sagging of skin or the wrinkling of skin, and the present disclosure provides a skin state evaluation method in which the state of skin is evaluated by employing the state of downy hair on skin as a criterion for the determination. More specifically, the present disclosure relates to a method for evaluating the state of skin by employing, as an evaluation item, at least one of the density of downy hairs, the thickness of downy hair and the length of downy hair. Also provided are an apparatus and program both for performing the evaluation of the state of skin by employing the state of downy hair on skin as a criterion for the determination.

Abstract: Technologies for evaluating a user's musculoskeletal health and prescribing treatment plans for the user based on the musculoskeletal health is provided. The disclosed techniques include a computing system receiving input data from a client device. The system formatting the input data to generate one or more sets of user characteristic data values and determining initial levels of user musculoskeletal health for the user based upon the sets of user characteristic data values. The system selects a set of treatment plans for the user based on the initial levels of user musculoskeletal health. The system presents the set of treatment plans to the user using media that allows the user to interactively perform exercises prescribed in the treatment plan.

Abstract: A first user electronic device associated with a first user comprises a processor, a memory and a communicator, the memory storing instructions that are executable by the processor (S101). The communicator couples to a sleep monitoring device (S102) and receives sleep data for the first user from the sleep monitoring device (S103). The processor determines, from the sleep data, that a sleep metric exceeds a threshold (S104). The processor generates a notification indicating that the sleep metric exceeds the threshold (S105). The processor controls the communicator to transmit the notification to a second user electronic device associated with a second user (S106). The method enables the sharing of notifications from a first user to a second user based on a sleep metric derived from the sleep data.

Abstract: A system for detecting a neurological state of a brain of a patient is disclosed. The system comprises one or more recording arrays, a database, and a processor. The recording arrays comprise a plurality of recording electrodes having a diameter of less than about 1 mm and spaced by less than about 1 mm, and are configured to be minimally invasively inserted to the brain to record electrical signals from a target recording site. The database stores electrophysiological data relating to known electrophysiological signatures associated with neurological states. The processor is configured to receive recorded signals from the recording arrays, access the electrophysiological data from the database, identify electrophysiological signatures in the recorded signals based on the electrophysiological data, and determine the neurological state of the brain based on the identified electrophysiological signatures.

Abstract: Systems and methods of progression (e.g. continuous ongoing and long term) assessment of a neurological disease of a patient, including: receiving, from a device that is wearable by the patient, 3D acceleration data and at least one physiological signal; determining, by a server, with a dedicated deep learning algorithm a progression of a neurological disease of the patient based on the received 3D acceleration data and the at least one physiological signal, wherein determination of the progression of the neurological disease includes: determining a first metric for patient's activity, determining a second metric based on a measured gait speed, and aggregating the first metric and the second metric into a combined approximation of progression of the neurological disease.

Abstract: The presently disclosed subject matter includes computerized methods and systems for determining performance of human skills of a user by participating in interactive virtual experiences, obtaining user and experience measurements, analysing the performance and determining level of performance of the human skills.

Abstract: A wearable system comprising: a body covering configured to cover a body part of a subject; at least one device attached to a surface of the body covering at a predetermined location with respect to the body part, the at least one device comprising: a skin-proximate layer configured to engage with a skin of the subject in a contact engagement at the predetermined location, an attachment layer configured to attach to the surface of the body covering, and a resilient layer disposed between the skin-proximate layer and the attachment layer, wherein the body covering and the resilient layer are configured to cooperate to exert a combined force which tends to urge the device towards the skin of the subject at the predetermined location.

Abstract: A wearable system (100) for tracking hand and wrist motion and forces includes a wearable pod (102) configured to be worn on a wrist or a back of a hand. the pod including: a sensor (104) configured to output a movement and an orientation measurement of the wrist or hand: a haptic feedback device (106) configured to provide sensory feedback to the hand or wrist: a processor (108) in communication with the at least one sensor and the haptic feedback device. the processor configured to determine whether the hand is in a neutral position based on the movement and orientation measurement of the wrist or hand and output a haptic feedback signal to the haptic feedback device based on the determination of whether the hand is in a neutral position: and a memory in communication with the processor and configured to record measurements from the sensors as measurement data.

Abstract: A system for monitoring a vital sign of a living organism, wherein the system comprises a patch device configured to be placed on the living organism, wherein the patch device comprises a sensor means configured to provide sensor data, is configured to determine a spatial orientation of the patch device by means of the sensor data when the patch device is placed on the living organism.

Abstract: This provision system includes: a presentation unit configured to present, to a user, a fact that contacting of a sensor with a body surface of the user serves as a condition for permission to provide a physical quantity to another entity other than the user, the sensor having a contact surface and being configured to measure the physical quantity, the physical quantity indicating a degree of change in a surface with which the contact surface contacts; an estimation unit configured to estimate a contact state of the sensor with the body surface on the basis of the physical quantity; and a provision unit configured to start providing the physical quantity to the other entity, on the basis of an estimation result for the contact state by the estimation unit.

Abstract: Disclosed herein are embodiments of a continuous multi-analyte monitor that can be used to measure one or more analytes, for example pH and lactate, in a patient. In some embodiments, the sensor can be implanted in the tissue of a patient, and a recording unit can be located on the skin of the patient, generally adjacent to the sensor. Detectors located on the sensor and on the recording unit can detect luminescent signals that originate from the implantable sensor and can be used to determine analyte concentrations, or otherwise relevant values.

Abstract: A measurement device of the present disclosure includes: a sensor configured to generate a first biological signal that is based on first biological information; a processor configured to generate a second biological signal by performing a noise reduction process on the basis of the first biological signal; and a storage configured to store a processing result of the noise reduction process. The processor is configured to perform the noise reduction process using the processing result stored in the storage on the basis of the first biological signal.

Abstract: A wearable computing device includes a PPG sensor that includes an emitter configured to output a light signal that is modulated with a carrier signal to generate a modulated light signal. The PPG sensor further includes one or more detectors configured to receive a first reflected light signal that is a reference signal of the modulated light signal without PPG data in the carrier signal and a second reflected light signal that is a reference signal of the modulated light signal with PPG data in the carrier signal. The wearable computing device further includes a control circuit configured to synchronously demodulate the first and second instances of the modulated light signal to obtain a first demodulated signal and a second demodulated signal, respectively. The control circuit is further configured to generate data indicative of one or more aggressors affecting the PPG data based on the first and second demodulated signals.

Abstract: A method of characterizing brain activity includes receiving an electroencephalogram (EEG) output. In addition, the method includes determining a mathematical model of a brain using the EEG output, wherein the mathematical model comprises a plurality of ordinary differential equations (ODEs) that are determined based on the EEG output. Further, the method includes characterizing brain activity of a subject using the mathematical model.

Abstract: Described are novel systems for the diagnosis of specific mental disorders using neurometrics. EEG parameters are compared to thresholds to determine if a person is suffering from autism spectrum disorder. Alzheimer's disease, anxiety, depression, or schizophrenia.

Abstract: Systems, methods, and computer programs disclosed herein relate to training and using a machine learning model to detect, identify and/or characterize body actions, in particular cough events.

Abstract: According to an embodiment of the present disclosure, there is provided a method of diagnosing left ventricular systolic dysfunction based on an electrocardiogram, the method being performed by a computing device including at least one processor, the method including: acquiring electrocardiogram data; and estimating the probability of occurrence of left ventricular systolic dysfunction for the subject of measurement of the electrocardiogram data based on the electrocardiogram data by using a pre-trained neural network model; wherein the neural network model has been trained based on the correlations between left ventricular systolic dysfunction and changes in electrocardiogram characteristics.