Patents Issued in March 25, 2025
  • Patent number: 12258279
    Abstract: A method for reducing waste by recovering a lithium precursor including: a) mixing a waste lithium secondary battery positive electrode material with urea to prepare a first mixture; b) firing the first mixture to prepare a second mixture; and c) subjecting the second mixture to water washing to obtain lithium hydroxide.
    Type: Grant
    Filed: November 30, 2021
    Date of Patent: March 25, 2025
    Assignee: SK INNOVATION CO., LTD.
    Inventors: Sukjoon Hong, Jiyun Park, Jeongbae Yoon, Seungok Lee, Jimin Kim, Sungreal Son
  • Patent number: 12258280
    Abstract: A method is disclosed for concentrating and purifying an eluate brine and producing a purified lithium compound. An extraction eluate, rich in lithium, is directed to a nanofiltration unit or a softening process that removes sulfate and/or calcium and magnesium. Permeate from the nanofiltration unit or the effluent from the softening process is directed through an electrodialysis unit. As the lithium-rich solution moves through the electrodialysis unit, lithium, sodium and chloride ions pass from the solution through a cation-transfer membrane and an anion-transfer membrane to concentrate compartments. A dilute stream is directed through the concentrate compartments and collects the lithium, sodium and chloride ions. The electrodialysis unit also produces a product stream which contains non-ionized impurities, such as silica and/or boron. Concentrate from the electrodialysis unit is subject to a precipitation process that produces a lithium compound that is subsequently subjected to a purification process.
    Type: Grant
    Filed: March 9, 2020
    Date of Patent: March 25, 2025
    Assignee: Veolia Water Solutions & Technologies Support
    Inventor: Bernard Roy Mack
  • Patent number: 12258281
    Abstract: The invention relates to a strontium aluminate mixed oxide precursor and a method for producing same, as well as to a strontium aluminate mixed oxide and method for producing same. The strontium aluminate mixed oxide precursor can be transformed into a strontium aluminate mixed oxide at relatively low temperature. The strontium aluminate mixed oxide is characterized by substantially spherically-shaped particles with a spongy- or porous bone-like microstructure. A luminescent material including a strontium aluminate mixed oxide is also provided.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: March 25, 2025
    Inventors: Thomas Harmening, Marcos Schoneborn
  • Patent number: 12258282
    Abstract: A method for producing a nickel sulfate solution includes a leaching step of leaching a nickel cathode in sulfuric acid under a high temperature and a high pressure to produce a leachate, a neutralization step of neutralizing the leachate produced in the leaching step to produce a neutralized solution, and a filtration step of filtering the neutralized solution produced in the neutralization step to produce a filtrate.
    Type: Grant
    Filed: September 22, 2023
    Date of Patent: March 25, 2025
    Assignees: KOREA ZINC CO., LTD., KEMCO
    Inventors: Heon Sik Choi, Jae Hoon Joo, Tae Kyung Lee
  • Patent number: 12258283
    Abstract: Systems, devices, and techniques described herein relate to iron-based desalination of water. In some cases, an inflow of water including chlorine and sodium can be received. A plurality of iron nanoparticles may capture the chlorine and the sodium. The iron nanoparticles may at least partially include Zero Valent Iron (ZVI). An outflow of the water may be emitted. The chlorine and the sodium may be omitted from the outflow.
    Type: Grant
    Filed: May 1, 2023
    Date of Patent: March 25, 2025
    Assignee: Badwater Alchemy Inc.
    Inventor: William J. Walker
  • Patent number: 12258284
    Abstract: There is provided an activated carbon having a high total trihalomethane filtration capacity, even in water treatment by passing water at a high superficial velocity (SV). In the activated carbon of the present invention, a pore volume A (cc/g) of pores with a size of 1.0 nm or less, of pore volumes calculated by the QSDFT method, is 0.300 cc/g or more, and elemental vanadium and/or a vanadium compound is contained.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 25, 2025
    Assignees: AD'ALL CO., LTD., UNITIKA LTD., OSAKA GAS CHEMICALS CO., LTD.
    Inventors: Tomoyasu Nakano, Hirokazu Shimizu, Keiji Sakai
  • Patent number: 12258285
    Abstract: Band-pass filters for guiding or controlling crystal polymorphism in water are provided. Band-pass filters convert a passive energy source to a spectral energy pattern tuned to resonant with different types of molecular oscillations pertinent to water. Tuned energy patterns convert problematic insoluble crystals to more thermodynamically stable and soluble crystals. Methods include use of the band-pass filter in water and design of band-pass filter parameters for optimal use on a particular water source.
    Type: Grant
    Filed: January 29, 2019
    Date of Patent: March 25, 2025
    Assignee: SYNERGETIC OIL TOOLS, INC.
    Inventor: Amber T. Krummel
  • Patent number: 12258286
    Abstract: Provided is a method for concentrating high-salinity raw water to obtain produced water satisfying Equation 1: Ns=B*(Cm?Cp)??<Equation 1> wherein: B is a salt permeability constant (B-value), and is 3 GFD?B?150 GFD, Ns is an amount of salt permeating the separation membrane (GFD*ppm), and has a value of Fp*Cp, Cm is a raw water-side separation membrane surface concentration (membrane concentration) (ppm), Cp is a produced water salt concentration (permeate concentration) (ppm), and Fp is produced water flux (permeate flux), and is 5 GFD?Fp?100 GFD, by the method comprising passing raw water having a salt concentration of 70,000 ppm or greater through a separation membrane at a temperature of 40° C. or less and a pressure of 1,200 psi or less.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: March 25, 2025
    Assignee: LG Chem, Ltd.
    Inventors: Jongbum Park, Phill Lee, Younghoon Ko, Young Jun Shin
  • Patent number: 12258287
    Abstract: Disclosed is a method, a device, and/or a system of water treatment through ozone generated from an invertible ozonation cap attachable to a vessel. In one embodiment, a cap for treating water inside a vessel includes an exterior surface of the cap, a fastener for attaching the cap to an opening of the vessel, a power source, an electrolytic ozone generator comprising an electrode that generates dissolved ozone and/or ozone gas when both the electrode is exposed to the water and a current from the power source is applied to the electrode, and an interior surface of the cap that exposes an anode of the electrode such that the water inside the vessel can contact the anode when the cap is inverted such that the dissolved zone and/or ozone gas rises up through the water of the vessel for increased water treatment effectiveness.
    Type: Grant
    Filed: September 15, 2020
    Date of Patent: March 25, 2025
    Inventor: Marianna DeMyer
  • Patent number: 12258288
    Abstract: A biogas treatment process is integrated with a water treatment process to adjust the pH level of the water and to provide more effective disinfection of the water. A water wash process is utilized to separate methane and carbon dioxide present in the biogas. During the water wash process, the biogas is mixed with water and the carbon dioxide is absorbed into the water. Because the process typically occurs at an elevated pressure and reduced temperature to enhance the solubility of carbon dioxide in water, the water stream becomes supersaturated with carbon dioxide. This water stream, which is supersaturated with carbon dioxide, is provided to the water treatment process to adjust the pH level of the water treatment process. The pH level is regulated to a desired level such that an increased relative concentration of hypochlorous acid is produced when sodium hypochlorite is added to the treatment process.
    Type: Grant
    Filed: May 14, 2024
    Date of Patent: March 25, 2025
    Assignee: Energy Tech Innovations, LLC
    Inventor: Bryan R. Johnson
  • Patent number: 12258289
    Abstract: A submerged combustion melting system includes a furnace including a tank with a floor, a roof, a perimeter wall, and an interior, and burners to melt glass feedstock into molten glass, a batch inlet, a molten glass outlet, and an exhaust outlet. An exhaust system is in fluid communication with the interior of the tank, and includes a flue in fluid communication with the exhaust outlet. A refractory-lined hood may be in fluid communication with the flue, which may be fluid-cooled including fluid-cooled perimeter panels and lower and upper baffles. The hood may include a protrusion that protrudes into a downstream horizontal exhaust path and has an excurvate upper surface to streamline flow of exhaust gas through the hood to prevent gas recirculation and formation of condensate piles in the hood.
    Type: Grant
    Filed: September 30, 2021
    Date of Patent: March 25, 2025
    Assignee: Owens-Brockway Glass Container Inc.
    Inventors: Shane T. Rashley, Robert W. Kuhlman, Richard C. Gobrecht, III, William Thomas, Liming Shi
  • Patent number: 12258290
    Abstract: A method of assembling together a first part and at least one second part that are made of materials compatible with bonding by molecular adhesion includes a step of pressing a first surface of the first part against a second surface of the second part so as to create molecular bonds at an interface between the parts, and a step of consolidating the interface bonding as created in this way by heat treatment. The consolidation includes a step of emitting a power laser beam towards an impact point forming a portion of the outline of the interface, and a step of moving the impact point along the outline of the interface.
    Type: Grant
    Filed: November 25, 2022
    Date of Patent: March 25, 2025
    Assignee: SAFRAN ELECTRONICS & DEFENSE
    Inventors: Mathieu Picard, Bruno Letourneur, Bastien Henault, Alice Garnier
  • Patent number: 12258291
    Abstract: The present invention relates to an improved drywall finish and joint compound comprised of a mixture of fractured aluminum oxide, glass bead, calcium sulfate, calcium carbonate, magnesium aluminum phyllosilicate, aluminum silicate hydroxide, polyvinyl acetate, polyvinyl alcohol, metamorphic mineral, sodium bicarbonate, silicon and aluminides, talc, kaolin, and metal oxide. The improved drywall finish and joint compound is capable of adhering to drywall, wood, concrete, brick, stone, steel, and other surfaces, and can be applied using a conventional trowel or similar device, cures quickly, and eliminates the need for taping and bedding. The compound saves extensive time and labor when installing, repairing, or working with drywall.
    Type: Grant
    Filed: September 28, 2022
    Date of Patent: March 25, 2025
    Inventors: Sheila Cross, Kory Ehlert
  • Patent number: 12258292
    Abstract: The present disclosure concerns an aluminosilicate having a Blaine fineness of about 500 m2/kg to about 3000 m2/kg and/or a specific surface area of about 4 m2/g to about 20 m2/g, as well as the uses thereof. The present disclosure also comprises a dry cementing composition and a mortar or concrete composition, the compositions comprising said aluminosilicate. The present disclosure also comprises a process for the manufacture of aluminosilicate. The process comprises: roasting a spodumene concentrate in an acid medium; leaching the acidic roast spodumene concentrate so as to obtain a mixture comprising a solid comprising the aluminosilicate and a leachate; and separating the aluminosilicate from the leachate in an acid medium, wherein said aluminosilicate contains a calcium concentration of less than about 5%.
    Type: Grant
    Filed: June 7, 2023
    Date of Patent: March 25, 2025
    Assignee: NEMASKA LITHIUM INC.
    Inventors: Jean-François Magnan, David-Nicolas Allen
  • Patent number: 12258293
    Abstract: A hybrid additive for use in construction materials such as asphalt and concrete is disclosed. The additive includes pellets formed of a plastic or polymer material, and one or more of fibers, pozzolans, nano-carbon tubes, glass, recycled asphalt shingles (RAS), liquid anti-strip, hydrated lime, rejuvenators, cementitious material, and ground tire rubber. Also disclosed are hybrid composite materials useful as paving and building materials, and methods of making the same. The hybrid additives were found to maintain the positive performance aspects of typical asphalt and concrete mixtures, while improving the performance of the mixtures by increasing bonding and strength within the mixture—and therefore increasing useable life and lowering costs.
    Type: Grant
    Filed: August 31, 2021
    Date of Patent: March 25, 2025
    Assignee: New Village Initiative LLC
    Inventors: Gary Beeman, Andrew T. LaCroix, Donald Russell, Michael Yonker, Mark D. Beeman
  • Patent number: 12258294
    Abstract: A process for producing cement includes combining a cement precursor and a wax, wherein the wax includes alkyl ketene dimer wax and/or alkenyl ketene dimer wax, grinding the cement precursor and the wax to yield cement grains coated with the wax. A cement includes cement powder grains and a coating of wax on the Portland cement powder grains, wherein the wax includes alkyl ketene dimer wax and/or alkenyl ketene dimer wax. A process for making cementitious material includes combining a cement with water to yield a slurry, wherein the cement includes cement powder grains and a coating of wax on the cement powder grains, wherein the wax includes alkyl ketene dimer wax and/or alkenyl ketene dimer wax, and allowing the slurry to set.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: March 25, 2025
    Assignee: MACROCEMENT INDUSTRIES LTD.
    Inventors: Alexander Ozersky, Alexander Khomyakov
  • Patent number: 12258295
    Abstract: A use of a thiosulfate as a retarder for a cement paste comprising a magnesium phosphate cement.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: March 25, 2025
    Assignees: ORANO DEMANTELEMENT, UNIVERSITE GUSTAVE EIFFEL
    Inventors: Lavinia Stefan, Thierry Chaussadent, Hela Bessaies-Bey
  • Patent number: 12258296
    Abstract: The disclosure belongs to the technical field of materials for civil construction engineering, and specifically relates to a green and low carbon emission foamed lightweight soil prepared by using serpentine, magnesium oxide and CO2 as raw materials. In the serpentine carbon sequestration foamed lightweight soil, the ingredients of raw material include: magnesium oxide, serpentine, a filler, CO2 bubbles and water.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: March 25, 2025
    Assignee: Southeast University
    Inventors: Songyu Liu, Xiang Zhang, Zhenyang Yuan
  • Patent number: 12258298
    Abstract: A method for manufacturing a ceramic member includes a mark process for forming a mark indicating information about a ceramic green body on the ceramic green body by using a mark material capable of being erased by a predetermined heat treatment; and a heat treatment process for erasing the mark by applying the ceramic green body to the predetermined heat treatment.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: March 25, 2025
    Assignee: NGK INSULATORS, LTD.
    Inventors: Rie Nishimura, Shinji Fujisaki, Makoto Ohmori
  • Patent number: 12258299
    Abstract: The present invention refers to a permanent solid calcium fertilizer suitable against fruit physiological disorders and pests, characterized in that it comprises more than 98.5% weight of calcium carbonate. It is also an object of the invention the use of this fertilizer for the protection of agricultural crops against pests and preferably for the protection of pear and/or apple crops.
    Type: Grant
    Filed: December 30, 2019
    Date of Patent: March 25, 2025
    Assignee: S.A. Reverté Productos Minerales
    Inventor: Arcadio Prieto Gigó
  • Patent number: 12258300
    Abstract: A method of making one or more alkyl thiophosphoric triamides.
    Type: Grant
    Filed: September 19, 2024
    Date of Patent: March 25, 2025
    Assignee: Soilgenic Technologies, LLC
    Inventors: Gary David McKnight, Randall Linwood Rayborn
  • Patent number: 12258301
    Abstract: A process for oligomerizing olefin streams comprising sending olefin streams comprising a C2? olefin vapor stream and a C3+ olefin liquids stream to a first stage oligomerization reactor containing a solid acid oligomerization catalyst to produce a first stage oligomerized stream; oligomerizing said first-stage oligomerization stream in a second stage oligomerization reactor containing a metal catalyst to provide a second stage oligomerized stream.
    Type: Grant
    Filed: January 19, 2024
    Date of Patent: March 25, 2025
    Assignee: UOP LLC
    Inventors: Ashish Mathur, Debanjan Chakrabarti, Jeannie Mee Blommel, Richard K. Hoehn, Joel S. Paustian, Manuela Serban
  • Patent number: 12258302
    Abstract: A process for producing high octane alkylate is provided. The process involves reacting isobutane and ethylene using an ionic liquid catalyst. Reaction conditions can be chosen to assist in attaining, or to optimize, desirable alkylate yields and/or properties.
    Type: Grant
    Filed: March 19, 2024
    Date of Patent: March 25, 2025
    Assignee: CHEVRON U.S.A. INC.
    Inventors: Bong-Kyu Chang, Hye-Kyung Cho Timken, Huping Luo
  • Patent number: 12258303
    Abstract: The present invention relates to metal salts of 2-[3-[(3R)-3-[[2-chloro-3-(trifluoromethyl)phenyl]methyl-(2,2-diphenylethyl)amino]butoxy]phenyl]acetic acid which exhibit improved physical properties and stability. The invention also relates to pharmaceutical compositions including an effective amount of the metal salts, as well as methods of treating cancer including administration of a pharmaceutical composition including a salt of the invention to a subject in need thereof.
    Type: Grant
    Filed: December 7, 2023
    Date of Patent: March 25, 2025
    Assignee: Inspirna, Inc.
    Inventors: Stephen Wald, Eduardo J. Martinez, Samuel Stratford, Amanda Buist, Joseph Benson, Jonathan Loughrey
  • Patent number: 12258304
    Abstract: This document discloses a novel class of compounds for inhibiting bacterial growth and treating bacterial infection. The compounds target a key step of the futalosine pathway and therefore are effective for the selective inhibition of certain bacterial species and genera with reduced side effect in comparison with conventional antibiotics.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: March 25, 2025
    Assignees: Albert Einstein College of Medicine, Victoria Link Limited
    Inventors: Steven C. Almo, Tyler Grove, Lawrence D. Harris, Gary B. Evans
  • Patent number: 12258305
    Abstract: The present invention provides novel compounds which activate the Kv7 potassium channels. Separate aspects of the invention are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat disorders responsive to the activation of Kv7 potassium channels.
    Type: Grant
    Filed: July 20, 2022
    Date of Patent: March 25, 2025
    Assignee: H. Lundbeck A/S
    Inventors: Mario Rottlander, Anette Graven Sams, Xiaofang Wang, Debasis Das, Jian Hong, Shu Hui Chen
  • Patent number: 12258306
    Abstract: The present invention relates to a diamine, and a polymer and film produced using the same. Specifically, the diamine may be significantly effectively used as a monomer for producing a polyimide-based film that is colorless and transparent and has improved mechanical strength.
    Type: Grant
    Filed: September 30, 2022
    Date of Patent: March 25, 2025
    Assignees: SK Innovation Co., Ltd., SK ie technology Co., Ltd.
    Inventors: Hyun Kyu Cho, Jin Hyung Park, Hyo Shin Kwak, Seung Min Jeon, Jong Chan Kim, Joo Hyun Lee
  • Patent number: 12258307
    Abstract: A satellite system operates at altitudes between 180 km and 350 km relying on vehicles including an engine to counteract atmospheric drag to maintain near-constant orbit dynamics. The system operates at altitudes that are substantially lower than traditional satellites, reducing size, weight and cost of the vehicles and their constituent subsystems such as optical imagers, radars, and radio links. The system can include a large number of lower cost, mass, and altitude vehicles, enabling revisit times substantially shorter than previous satellite systems. The vehicles spend their orbit at low altitude, high atmospheric density conditions that have heretofore been virtually impossible to consider for stable orbits. Short revisit times at low altitudes enable near-real time imaging at high resolution and low cost. At such altitudes, the system has no impact on space junk issues of traditional LEO orbits, and is self-cleaning in that space junk or disabled craft will de-orbit.
    Type: Grant
    Filed: November 27, 2023
    Date of Patent: March 25, 2025
    Assignee: Skeyeon, Inc.
    Inventors: Ronald E. Reedy, Thomas E. Schwartzentruber
  • Patent number: 12258308
    Abstract: A compound represented by general formula (I) (in the formula, all symbols are as described in the description) or a salt thereof has a potent nerve-protecting and/or -repairing activity, and therefore can be used as a therapeutic agent for neuropathy (e.g., chronic inflammatory demyelinating polyneuropathy, Guillain-Barre syndrome, periarteritis nodosa, allergic vasculitis, diabetic peripheral neuropathy, entrapment neuropathy, peripheral neuropathy associated with the administration of a chemotherapeutic drug, or peripheral neuropathy associated with Charcot-Marie-Tooth disease).
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: March 25, 2025
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Shoji Nojima, Kenji Sasaki, Tohru Kambe, Takashi Konemura, Yoshikazu Goto
  • Patent number: 12258309
    Abstract: Some aspects provide novel dofetilide derivatives and pharmaceutical compositions containing the same that are useful as pharmaceutical agents in the treatment of supraventricular and ventricular arrhythmias.
    Type: Grant
    Filed: July 6, 2023
    Date of Patent: March 25, 2025
    Assignee: Academic Pharmcauticals, Inc.
    Inventors: John Somberg, Robert J Chorvat
  • Patent number: 12258310
    Abstract: Peroxyhydroxycarboxylic acid forming compositions and methods for forming peroxyhydroxycarboxylic acids, preferably in situ, using the peroxyhydroxycarboxylic acid forming compositions are disclosed. Methods of using the peroxyhydroxycarboxylic acids, including for treating a surface or a target in need of antimicrobial or sanitizing treatment are also disclosed. Particular applications of using odor-free, low volatility peroxyhydroxycarboxylic acid sanitizers for direct food contact are disclosed.
    Type: Grant
    Filed: July 10, 2023
    Date of Patent: March 25, 2025
    Assignee: ECOLAB USA INC.
    Inventors: Junzhong Li, Allison Prideaux, Richard Staub
  • Patent number: 12258311
    Abstract: The present invention relates to a new compound and the dehydrogenation of that compound to produce retinal.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: March 25, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg, Viktor Zimmermann
  • Patent number: 12258312
    Abstract: The present application relates to a compound of the following formula (I) in which —R1, R2, R3 and R4 represent independently of each other H or a (C1-C30) alkyl group, the total sum of the number of carbon atoms of R1, R2, R3 and R4 being equal to 6+4x, x being a whole number of between 1 and 6, provided that: at most two of the groups R1, R2, R3 and R4 are H, R5 represents H, OR, or NR?R? R, R? and R?, identical or different, represent H, a (C1-C10) alkyl group, at least one of groups R1, R2, R3 or R4 comprises or is a tertiobutyl group. (I) the method for preparing same and the uses thereof as a plasticising lubricant, surfactant or in a cosmetic composition.
    Type: Grant
    Filed: August 17, 2020
    Date of Patent: March 25, 2025
    Assignee: Global Bioenergies
    Inventors: Serge Ratton, Marc Lemaire, Luc Mathis, Estelle Metay
  • Patent number: 12258313
    Abstract: A method for purifying cumene may include splitting an alkylation reaction product into a first portion and a second portion; feeding the first portion as mostly a liquid into a benzene column; at least partially vaporizing the second portion in a heater; feeding the at least partially vaporized second portion into the benzene column. A method for purifying cumene may also include the steps of providing a benzene column and a cumene column; directing a liquid side draw from the benzene column to the cumene column, the liquid side draw being a liquid substantially free of DIPB; returning a benzene enriched vapor from the cumene column to the benzene column using an overhead line, the benzene enriched vapor having a higher concentration of benzene than the liquid side draw; and drawing purified cumene from the cumene column.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: March 25, 2025
    Assignee: KELLOGG BROWN & ROOT LLC
    Inventors: Rian Reyneke, Eric Wing-Tak Wong
  • Patent number: 12258314
    Abstract: Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.
    Type: Grant
    Filed: December 22, 2021
    Date of Patent: March 25, 2025
    Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
    Inventors: Troy E. Messick, Garry R. Smith, Allen B. Reitz, Paul M. Lieberman, Mark E. McDONNELL, Yan Zhang, Venkata Velvadapu
  • Patent number: 12258315
    Abstract: The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer.
    Type: Grant
    Filed: December 15, 2023
    Date of Patent: March 25, 2025
    Assignee: Xavier University of Louisiana
    Inventors: Jayalakshmi Sridhar, Melyssa Bratton, Rajesh Komati
  • Patent number: 12258316
    Abstract: This invention provides compounds of formula I: wherein a, b, c, d, m, n, p, s, t, W, Ar1, R1, R2, R3, R4, R6, R7, and R8 are as defined in the specification. The compounds of formula I are muscarinic receptor antagonists. The invention also provides pharmaceutical compositions containing such compounds, processes and intermediates for preparing such compounds and methods of using such compounds to treat pulmonary disorders.
    Type: Grant
    Filed: January 5, 2022
    Date of Patent: March 25, 2025
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventors: Mathai Mammen, YuHua Ji, YongQi Mu, Craig Husfeld, Li Li
  • Patent number: 12258317
    Abstract: An isoquinolinone compound acts as an inhibitor of semicarbazide-sensitive oxidase (SSAO) and/or vascular adhesion protein-1 (VAP-1), and the use thereof, and further relates to a pharmaceutical composition containing the compound. The compound or the pharmaceutical composition can be used to prepare a drug for preventing, treating or ameliorating inflammation and/or inflammation-related diseases, diabetes and/or diabetes-related diseases in patients, and especially can be used to prepare a drug for preventing, treating or ameliorating non-alcoholic fatty liver diseases in patients.
    Type: Grant
    Filed: May 20, 2020
    Date of Patent: March 25, 2025
    Assignee: SUNSHINE LAKE PHARMA CO., LTD.
    Inventors: Zheng Gu, Jianhao Li, Weihua Wang, Haoxiong Qin, Xinshan Deng
  • Patent number: 12258318
    Abstract: The present application provides a synthesis method for 1-methyl-1H-indazole-6-carboxylic acid. The synthesis method comprises: using 2-fluoro-4-bromobenzaldehyde and methylhydrazine as raw materials to obtain 6-bromo-1-methylindazole by means of an annulation reaction, and then performing a methyl formate reaction and a hydrolysis reaction, so as to obtain the 1-methyl-1H-indazole-6-carboxylic acid. The synthesis method provided in the present application can directly synthesize a 1-position methyl substituted indazole without isomers, thereby avoiding the problem that impurities are difficult to be removed in subsequent separation, thus improving the purity of a product. The yield of the annulation reaction can reach 85%.
    Type: Grant
    Filed: June 3, 2020
    Date of Patent: March 25, 2025
    Assignee: ACCELA CHEMBIO CO., LTD.
    Inventors: Jun Yang, Duoqing Xue, Yong Wu, Lihuang Chen, Lianhua Zhai
  • Patent number: 12258319
    Abstract: A process is provided for manufacturing a cyclic urea adduct of an ethyleneamine compound, the ethyleneamine compound having a linear —NH—CH2—CH2—NH— group. The process includes, in an absorption step, contacting a liquid medium comprising an ethyleneamine compound having a linear —NH—CH2—CH2—NH— group with a CO2-containing gas stream at a pressure of from about 1 to about 20 bara, resulting in the formation of a liquid medium into which CO2 has been absorbed. The process further includes bringing the liquid medium to cyclic urea formation conditions, and, in an urea formation step, forming cyclic urea adduct of the ethyleneamine compound, urea formation conditions including a temperature of at least about 120° C., wherein the total pressure at the end of the urea formation step is at most about 20 bara, and wherein the temperature in the absorption step is lower than the temperature in the urea formation step.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: March 25, 2025
    Assignee: NOURYON CHEMICALS INTERNATIONAL B.V.
    Inventors: Rens Veneman, Antoon Jacob Berend Ten Kate, Karl Fredrik Lake, Jenny Valborg Therese Adrian Meredith, Michiel Jozef Thomas Raaijmakers, Slavisa Jovic, Rolf Krister Edvinsson, Hendrik Van Dam, Eike Nicolas Kantzer, Ina Ehlers
  • Patent number: 12258320
    Abstract: The present disclosure encompasses solid state forms of Mavacamten, in embodiments crystalline polymorphs of Mavacamten, processes for preparation thereof, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: March 20, 2024
    Date of Patent: March 25, 2025
    Assignee: ASSIA CHEMICAL INDUSTRIES LTD.
    Inventors: Lorena Kordić, Dijana Škalec Šamec
  • Patent number: 12258321
    Abstract: Compounds belonging to the group of N-benzyl-2-(4-(4-substituted-1H-1,2,3-triazol-1-yl)phenylacetamides have cytotoxic activities against MCF7 breast cancer cells, and are useful in therapeutic regimes for breast cancer. The N-benzyl-2-(4-(4-substituted-1H-1,2,3-triazol-1-yl)phenylacetamides also have beneficial effects on BAX, BCL-2, MCL-1 and MAPK pathways within MCF& breast cancer cells.
    Type: Grant
    Filed: October 14, 2024
    Date of Patent: March 25, 2025
    Assignees: University of Jeddah, King Abdulaziz University, Helwan University
    Inventors: Roaa M. Alreemi, Hind A. Alkhatabi, Mohammed A. Baradwan, Abdelsattar M. Omar, Moustafa E. El-Araby, Yara E. Mansour, Samar S. Fatahala, Ahmed M. Said, Shahenda Mahgoub
  • Patent number: 12258322
    Abstract: The present invention relates to a method for preparing dihydroxyammonium 5,5?-bistetrazole-1,1?-diolate. The method for preparing dihydroxyammonium 5,5?-bistetrazole-1,1?-diolate, according to one embodiment of the present invention, comprises the steps of: synthesizing 5,5?-bistetrazole-1,1?-diol dihydrate (1,1?-BTO) from ditetrahydropyranyl diazidoglyoxime (THP-DAG) by using a hydrochloric acid (HCl) solution in a first solvent; and reacting 1,1?-BTO with an amine solution so as to neutralize same and, simultaneously, obtaining dihydroxylammonium 5,5?-bistetrazole-1,1?-diolate (Thomas Klapotke explosive-50, TKX-50).
    Type: Grant
    Filed: June 1, 2023
    Date of Patent: March 25, 2025
    Assignee: AGENCY FOR DEFENSE DEVELOPMENT
    Inventors: Kuk Tae Kwon, Hae Wook Yoo, Seung Hee Kim, So Jung Lee
  • Patent number: 12258323
    Abstract: The present invention provides dihydrooxydiazinone compounds of general formula (I): in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: July 11, 2022
    Date of Patent: March 25, 2025
    Assignees: Bayer Aktiengesellschaft, Bayer Pharma Aktiengesellschaft, The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc.
    Inventors: Manuel Ellermann, Stefan Nikolaus Gradl, Charlotte Christine Kopitz, Martin Lange, Adrian Tersteegen, Philip Lienau, Christa Hegele-Hartung, Detlev Sülzle, Timothy A. Lewis, Heidi Greulich, Xiaoyun Wu, Matthew Meyerson, Alex Burgin
  • Patent number: 12258324
    Abstract: Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases or conditions, such as cancer. In one aspect, the method comprises the treatment of metastatic cancers. Compounds and methods provided herein are also used for the treatment of diseases such as inflammatory disease, cardiovascular disease, autoimmune disease, and dry eye syndrome. Further provided herein are dietary supplement formulations and methods for supporting a healthy lifestyle.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: March 25, 2025
    Inventors: Yu-Hsin Tom Lin, Cheng-Chi Irene Wang, Jason Olejniczak
  • Patent number: 12258325
    Abstract: Compositions and methods are provided for the production of bio-based polymers (e.g., polymers made from glucose), including polyesters, as well as end products resulting from such production, in which one or more color stabilizing additive compounds is utilized. The additive(s) may be used in the stabilization of a monomer or prepolymer that is reacted in such production methods, prior to obtaining the polymer. Particular bio-based polymers are those having furandicarboxylate moieties or residues in their backbone structure, with poly(alkylene furan dicarboxylate) polymers, such as polyethylene furan dicarboxylate) (PEF) and poly(trimethylene furan dicarboxylate) (PTF) being representative.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: March 25, 2025
    Assignees: Archer Daniels Midland Company, DuPont Industrial Biosciences USA, LLC
    Inventors: Erik Hagberg, Chi Cheng Ma, Kenneth F. Stensrud
  • Patent number: 12258326
    Abstract: Embodiments provide a pest control agent that is excellent in safety, controlling effect, residual activity, and so on.
    Type: Grant
    Filed: March 18, 2024
    Date of Patent: March 25, 2025
    Assignee: KUMIAI CHEMICAL INDUSTRY CO., LTD.
    Inventors: Ryo Ishikawa, Akira Kinpara, Keiji Toriyabe, Akira Watanabe, Masao Nakatani, Akira Takanezawa, Takeshi Matsuda
  • Patent number: 12258327
    Abstract: Provided are 5-membered heteroaryl-containing aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: March 25, 2025
    Assignees: YUHAN CORPORATION, JANSSEN BIOTECH, INC.
    Inventors: Byoungmoon Lee, Hyunjoo Lee, Gyu Jin Lee, Su Bin Choi, Misong Kim, Young Ae Yoon, Kwan Hoon Hyun, Jae Young Sim, Marian C. Bryan, Scott Kuduk, James Campbell Robertson, Jaekyoo Lee, Paresh Devidas Salgaonkar, Byung-Chul Suh, Jong Sung Koh, So Young Hwang
  • Patent number: 12258328
    Abstract: Provided are 6-membered heteroaryl-containing aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.
    Type: Grant
    Filed: August 26, 2022
    Date of Patent: March 25, 2025
    Assignees: YUHAN CORPORATION, JANSSEN BIOTECH, INC.
    Inventors: Hyunjoo Lee, Su Bin Choi, Misong Kim, Young Ae Yoon, Kwan Hoon Hyun, Jae Young Sim, Marian C. Bryan, Scott Kuduk, James Campbell Robertson
  • Patent number: 12258329
    Abstract: The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: March 25, 2025
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Antonella Converso, Cheng Wang