Abstract: Systems and methods for a medical device are disclosed. For example, the medical device may be configured to release at least one agent from a housing upon interacting with a substance. The medical device may include a capsule wall defining the at least one housing, and a sensor configured to detect the substance. The housing may be configured to contain the at least one agent.

Abstract: A laryngoscope enhancement system (LES) and an intubation system including an LES are provided. The LES includes a holder and a video stylet. The holder includes an adjustable mount to releasably secure an electronic device with a display, and an end cap configured to removably attach the holder to an upper end of a laryngoscope handle. The video stylet includes a connector removably attachable to the electronic device, a flexible segment, a malleable segment and a video camera. The LES may include wireless communication capabilities.

Abstract: Methods, devices and systems are described that enable identification of cancerous or pre-cancerous colon tissue. The described methods and systems rely on non-imaging. randomly sampled second harmonic generation (SHG) intensity measurements that are sufficient for differentiating between tumor and normal tissue. The disclosed methods and system further provide for angle-resolved SHG measurements associated with forward and backward scattered light that eliminate the need to obtain paired normal and cancer-suspicious measurements in each patient using the described techniques.

Abstract: Methods and systems for providing a flow of fluid to an endoscope. An illustrative container and tube set arranged and configured to couple to an endoscope may comprise a first container configured to contain a fluid, the first container having a first port in fluid communication with a bottom portion thereof, a second container configured to contain a fluid, the second container having a first fluid inlet, wherein a first end of the first fluid inlet is coupled to the first port of the first container and a second end of the first fluid inlet is coupled to the second container, a first water supply tube, and a first gas supply tube. The first water supply tube and the first gas supply tube may each have a lumen in selective fluid communication with the second container and a second end external to the second container.

Abstract: The intraoral endoscope includes a housing (1) with a shielding window (6) disposed on a working end (101) of the housing (1). An optical sensor (8) connected to a microprocessor (4) is disposed inside the housing (1), in front of the shielding window (6). A backlight (5) is disposed inside the housing (1). The housing (1) is connected by a tube (3) to a compressed air supply source disposed outside the housing (1). The housing (1) comprises an opening for supplying air to an outer surface of the shielding window (6). A diffuser (7) is disposed inside the opening. The diffuser (7) is adapted to produce an air jet which generates an air curtain and has an outflow velocity from 6 m/s to 50 m/s forming an angle from 0° to 15° with a plane of the shielding window (6).

Abstract: A one-piece spacer for acquisition, with a mobile phone, of 2D or 3D representations of teeth of a user, the spacer comprising a tubular part having a longitudinal axis, the tubular part—having a length greater than 3 cm,—opening out via an acquisition opening and via an oral opening, being designed to be fixed detachably to the mobile phone in an acquisition position in which an optical objective of the mobile phone has an at least partial view of the oral opening through the acquisition opening, and—comprising a non-deformable portion, which opens out via the acquisition opening, and, in the continuation of the non-deformable portion, a deformable portion, which opens out via the oral opening and is deformable between a rest configuration in which the oral opening has a maximum area and a contracted configuration in which the oral opening has a minimum area.

Abstract: An oral health self-monitoring system includes a portable photo guide that is adapted to cooperate with a smartphone camera to obtain images of the patient's oral cavity. A processor, preferably programmed and operable to execute machine learning algorithms, analyzes the images for cavities and plaque. In some implementations, the portable photo guide includes an onboard camera, and the smart phone is connected to the camera and programmed to manage the camera to obtain images of the patient's oral cavity and to send them to a remote server for analysis.

Abstract: An image processing method includes acquiring a first direction fundus image imaged in a state in which an examined eye is directed in a first direction, and a second direction fundus image imaged in a state in which the examined eye is directed in a second direction different to the first direction, generating a combined image for analyzing a fundus-peripheral portion of the examined eye by combining the first direction fundus image and the second direction fundus image, and outputting the combined image.

Abstract: An eye imaging system including: an illumination device configured to illuminate a structure of an eye with a patterned or otherwise textured image; one or more image collection devices wherein; the one or more image collection devices are arranged to capture one or more images of the structure of the eye from one of a plurality of physical locations and/or from different perspectives, e.g. the capture images of the structure of the eye whilst the structure of the eye is illuminated by the patterned or otherwise textured image.

Abstract: Disclosed are methods and digital tools for deriving tooth condition information for a patient's teeth, for populating a digital dental chart with derived tooth condition information, and for generating an electronic data record containing such information.

Abstract: An oral diagnostic device includes a device main body including an optical transmitting and receiving module; and a probe that is detachably coupled to the device main body, irradiates light received from the optical transmitting and receiving module into an oral cavity, receives reflected light from the oral cavity, and transmits the received reflected light to the optical transmitting and receiving device. The optical transmitting and receiving module includes an optical element module including a light-emitting element and a light-receiving element, a single first optical fiber that transmits the light generated by the light-emitting element to the probe, and a plurality of second optical fibers that transmit the reflected light received from the probe to the light-receiving element. The single first optical fiber and the plurality of second optical fibers are coupled to each other at the other sides thereof to form an optical fiber coupling part.

Abstract: The invention relates to a device for optically detecting biofilm in the oral cavity, wherein at least one sensor unit is provided, wherein the sensor unit has a camera, which points with its optical detection region into a receiving space of the device and serves to record surfaces that are to be detected.

Abstract: A system may include a substrate in contact with a user. The substrate may include first detector(s) capable of detecting optical biometric properties of the user, and second detector(s) capable of detecting non-optical biometric properties of the user. The system may include a first and a second electronics module communicatively coupled to the substrate. Each of the two electronics modules may include a processor, a memory device, and instructions stored on the memory device that, when executed, direct the processor to perform step(s). These step(s) may include receiving a signal from the first detector(s) or second detector(s), processing the signal based on predefined algorithm(s), and determining, based on the processed signal, whether the user requires one or more feedback actions.

Abstract: A technique for obtaining an electrocardiogram of good waveform quality. A biological information measurement device for measuring a blood pressure and an electrocardiographic waveform of a subject includes: a blood pressure measurement control unit configured to control measurement of a blood pressure of a measurement site of the subject; a first electrode to be in contact with a first site of the subject; a second electrode to be in contact with a second portion of the subject different from the first site; an electrocardiographic measurement control unit configured to control measurement of an electrocardiographic waveform of the subject through the first electrode and the second electrode; a main body portion including the blood pressure measurement control unit and the electrocardiographic measurement control unit; an instruction input portion operated by the subject to input an instruction; and a fixing portion configured to fix the main body portion to the measurement site.

Abstract: Systems and methods for remote and host monitoring communication are disclosed. In some implementations, monitoring systems can comprise a host monitoring device associated with a Host communicatively coupled to one or more remote monitoring devices associated with Remote Monitors. The host monitoring device can send communications based at least in part on analyte measurements of a Host sensor and/or other contextual data giving such measurements context. Different remote monitoring devices can receive different communications based at least in part on the role of the respective Remote Monitors relative to the Host. These roles can be reflected in classifications of Remote Monitors.

Abstract: Systems and methods to determine an injury risk score for a subject are disclosed. Exemplary implementations may: determine, at individual instances based on output signals generated by a sensor group, parameter values for a parameter set including a load parameter, a form parameter, a fitness parameter, a fatigue parameter, and an environment parameter; obtain individual injury reports that characterize individual onsets and/or aggravations of injuries experienced by the subject during manual manipulation of one or more of the loads; determine correlations between the parameter values for the parameter set and the injury reports; determine weighted parameter values for the parameters of the parameter set based on the correlations; and determine an injury risk score for the subject by aggregating the weighted parameter values.

Abstract: A multi-sensor system is provided and integrated on one or more fibers, compatible with magnetic resonance (MR) imaging, capable of measuring temperature, pressure, and position during medical interventional procedures (ablation, catheter insertion into the body, etc.). The multi-sensor system includes a perforated membrane structure, a pressure measuring membrane, a semiconductor die, and a magnetic material.

Abstract: A sphygmomanometer configured to measure a blood pressure by compressing a part of a user to be measured with a cuff includes a blood pressure measurement unit configured to measure the user's blood pressure based on a pulse wave signal in a pressurization process of pressurizing a cuff pressure indicating an inner pressure of the cuff, a determination unit configured to determine whether an arrhythmia occurs in the user based on the pulse wave signal during the pressurization process, and a mode setting unit configured to set one of a first mode for executing the determining of the arrhythmia and a second mode for not executing the determining of the arrhythmia. The blood pressure measurement unit sets a first pressurization speed of the cuff pressure when the first mode is set to be lower than a second pressurization speed of the cuff pressure when the second mode is set.

Abstract: In some implementations, an apparatus may obtain activity information indicative of an activity performed by a person. The apparatus may update a model for determining blood pressure of the person based at least in part on the obtained activity information. The apparatus may detect an acoustic wave corresponding to a photoacoustic response of a blood vessel of the person to light emitted by a light source system. The apparatus may estimate a blood pressure based at least in part on the updated model and the acoustic wave. In some embodiments, the apparatus may comprise a wearable device worn by the person.

Abstract: A single-arm physiological signal measuring system, including a shell, a flexible electronic assembly, and an air bag, is provided. The flexible electronic assembly is disposed in the shell and surrounds to form a space. The flexible electronic assembly includes a photoplethysmography module, an electrocardiogram module, and a controller. The electrocardiogram module includes first and second electrocardiogram electrodes. The controller is electrically connected to the photoplethysmography module and the electrocardiogram module. The air bag is disposed between the shell and the flexible sensing assembly to push the flexible sensing assembly to change a size of the space. When the air bag is inflated, the photoplethysmography module, the first and second electrocardiogram electrodes are pushed by the air bag to touch an arm, so that the photoplethysmography module measures a blood oxygen saturation, the electrocardiogram module measures an electrocardiogram, and the controller calculates a blood pressure.

Abstract: The present technology generally relates to a sensor assembly for an implantable medical device. In some embodiments, the sensor assembly includes a housing having a cavity, and a measurement component positioned within the cavity. When the medical device is implanted within a patient, the sensor can be configured to measure one or more physiological parameters of the patient. In some embodiments, the sensor assembly further includes a coupling element positioned within the cavity and at least partially covering, contacting, or encapsulating the measurement component. The coupling element can be configured to transmit or convey the one or more physiological parameters to the measurement component, such that the measurement component can measure the one or more physiological parameters without exposure to an environment external to the sensor assembly.

Abstract: A blood-pressure gauge includes a blood pressure measurement unit that automatically performs blood pressure measurement according to a predetermined schedule in one of a plurality of blood pressure measurement modes. The plurality of blood pressure measurement modes include a normal measurement mode and a plurality of measurement modes having higher reliability than the normal measurement mode. The blood-pressure gauge further includes a determination unit that determines whether any of a plurality of events has occurred in a user during blood pressure measurement, and a mode setting unit that sets an active measurement mode from among the plurality of blood pressure measurement modes based on a determination result. The mode setting unit sets the normal measurement mode as the active measurement mode when no event has occurred, and sets one of the plurality of measurement modes as the active measurement mode when one of the events has occurred.

Abstract: Method and system for deriving interbeat interval (IB1) measurement of subject. A radar device receives a reflection radar signal reflected from subject. A signal portion of reflection radar signal at a range of subject is extracted, the signal portion collected over predefined intervals and consisting of an in-phase component and a quadrature component. The signal portion is filtered by applying a complex valued continuous wavelet transform (CWT) to derive a time domain ballistocardiograph (BCG) signal with cyclically repeating features, such that the time displacement between repeating features of the derived BCG signal is representative of a first heartbeat interval measurement of subject. At least one segment of the BCG signal over a selected time duration may be identified using a matrix profile technique, such that the time displacement between successive identified segments is representative of a second heartbeat interval measurement. Radar signal may be THz/millimeter-wave and FMCW radar signal.

Abstract: The present disclosure provides wearable devices for use in generating electrocardiograms. The wearable devices may be used by a user (e.g., in combination with an app) to determine a likelihood that the user is undergoing a health emergency. A wearable device may include at least 9 precordial leads. A wearable device may include one or more leads in a V7, V8, or V9 position, or a combination thereof. A wearable device may include two rows of leads (e.g., two leads in each of a number of positions).

Abstract: A sphygmomanometer includes a blood pressure measurement unit configured to measure a user's blood pressure based on a pulse wave signal in a pressurization process of pressurizing a cuff pressure indicating an inner pressure of a cuff worn on a part of the user to be measured. The blood pressure measurement unit sets a pressurization speed in a predetermined period of a pressurization process to be slower than a pressurization speed in a period other than the predetermined period in the pressurization process. The predetermined period is set based on a timing at which the amplitude of the pulse wave signal during the pressurization process is maximum or the timing at which the cuff pressure during the pressurization process is an average blood pressure of the user. The sphygmomanometer further includes a determination unit that determines arrhythmia of the user based on the pulse wave signal in the pressurization process.

Abstract: A sphygmomanometer includes a blood pressure measurement unit that measures a blood pressure of a user based on a pulse wave signal in a pressurization process of increasing a cuff pressure indicating a pressure inside a cuff worn around a measurement site of the user, and a pulse rate measurement unit that measures a pulse rate of the user based on the pulse wave signal in the pressurization process. The blood pressure measurement unit determines whether to continue the pressurization process based on a pulse rate. The sphygmomanometer further includes a monitoring unit that monitors an arrhythmia of the user based on a pulse wave signal in the pressurization process.

Abstract: A sphygmomanometer configured to measure a blood pressure by compressing a part of a user to be measured with a cuff, the sphygmomanometer including a blood pressure measurement unit configured to, after a pressurization process of pressurizing a cuff pressure indicating an inner pressure of the cuff to a pressure greater than a specified pressure, measure the blood pressure of the user based on a pulse wave signal in a depressurization process of depressurizing the cuff pressure, a determination unit configured to determine whether or not an arrhythmia occurs in the user based on the pulse wave signal in the depressurization process, and a mode setting unit configured to set one of a first mode for executing the determining of the arrhythmia and a second mode for not executing the determining of the arrhythmia.

Abstract: A medical device and method of using the medical device include de following: (a) a device capable of generating a sinusoidal voltage at a fixed initial frequency for a specified time followed by a logarithmic sweep between that initial frequency and a final frequency in a total time of 0.5 seconds; and (b) one or several live microelectrodes and one ground electrode, all of them electrically separated by electrically insulating regions; (c) a strategy to obtain the experimental electrical resistance and capacitance values as a function of the excitation frequency of the sweep mentioned in a); and (d) an artificial intelligence, machine learning, linear discriminant analysis method to determine whether the patient has an ocular pathology or not based on the measurement of the electrical resistance and capacitance as a function of frequency in 0.5 seconds.

Abstract: An electroanatomical mapping system identifies optimized interconnections between ablation lesion segments. The system receives lesion markers, each representing an ablation lesion segment, and defines one or more disjoint subsets thereof. For each disjoint subset, the system defines optimized interconnections between lesion markers and outputs a graphical representation of the disjoint sets and the optimized interconnections. The disjoint subsets may be defined as minimum cost spanning trees. The optimized interconnections can include the edges of the minimum cost spanning tree as well as additional cycle-closing edges that are not edges of the minimum cost spanning tree, where the cycle-closing edges are leaf edges that satisfy one or more cycle-closing criteria.

Abstract: A system for measuring and characterizing respiration-related parameters using sound. A microphone in an existing application (such as an aviation oxygen mask) can be used. Alternatively, a microphone can be added to carry out the present invention. Such a microphone is preferably added to an existing device—such as a nasal dilator.

Abstract: Examples provide a system and method for continuous respiratory rate monitoring with greater accuracy and reliability. Sensor data is obtained from a wearable sensor device simultaneously generating both multi-wavelength photoplethysmography (PPG) sensor data as well as inertial measurement unit (IMU) sensor data, such as respiratory body movement data generated by an accelerometer and/or a gyroscope. The system performs signal processing and filtering on the sensor data using a set of rules and threshold(s) to remove Mayer-wave in-band noise, transients, and motion artifacts. PPG-based respiratory rate estimates are generated and combined into a single PPG-based respiratory rate estimate based on the PPG sensor data. IMU-based respiratory rate estimates are generated and combined in parallel using the IMU sensor data to generate a single IMU-based respiratory rate estimate.

Abstract: In accordance with an embodiment, a method includes activating, in response to a detected vibration signal, a microphone to perform audio recording to obtain audio recording data, wherein the headset is worn around a head and neck region of a user; detecting whether the audio recording data comprises a cough sound; and sending the audio recording data to a smart terminal device in response to the audio recording data comprising the cough sound, so that the smart terminal device analyzes and collects statistics on cough information about the user based on the audio recording data.

Abstract: A system for detecting possible diaper changes in bedridden patients includes a load cell and a computer configured to receive data from the load cell. The load cell is placed under a bed and is configured to detect changes in the forces applied onto the load cell. These changes in forces may include changes in the apparent bed weight and an indicator of detected movement strength. The data from the load cell may be processed by the computer to determine whether a diaper change has likely occurred. The computer may be configured to apply machine learning techniques to compare data patterns from the load cell with previous data corresponding to known diaper changes.

Abstract: A method and system for calibrating cameras of a monitoring system, the method comprises receiving a plurality of video frames including a wide area view of a patient area from a primary camera of a monitoring subsystem and a view of a region of interest within the patient area from a secondary camera of the monitoring subsystem, detecting a patient event based on an analysis of given ones of the plurality of video frames corresponding to the wide area view, transmitting the given ones of the plurality of video frames and an identification of the patient event to a viewer client device, generating detection-based calibration instructions based on the patient event, wherein the detection-based calibration instructions including control information that controls operation of the secondary camera based on a location of the patient event, and transmitting the detection-based calibration instructions to the monitoring subsystem, wherein the monitoring subsystem configures the secondary camera based on the control

Abstract: An acquisition unit acquires image data indicating at least a chest and an abdomen of a test subject. A detection unit detects the displacement of each of the chest and abdomen of the test subject by using the image data. A display control unit performs control so that the movement image of each of the chest and abdomen is displayed based on the detected displacement of the chest and abdomen. When the movement of the chest and the movement of the abdomen are synchronized with each other, the display control unit performs control so that the display form of the chest movement image and the display form of the abdomen movement image are the same as each other.

Abstract: A multisensory device includes two or more sensors in contact with a channel, each sensor configured to output a corresponding level of an analyte in a sample in the channel. The multisensory device includes an analyzer having a memory and one or more processors. The analyzer is configured to receive a first input signal from a first sensor indicating a level of a first analyte and receive a second input signal from a second sensor indicating a level of a second analyte. The analyzer estimates the level of the second analyte based on a trace of the first input signal. The analyzer determines whether the level of the second analyte measured by the second sensor is comparable to the estimated level of the second analyte. The analyzer outputs an indication of the level of each of the first analyte and the second analyte.

Abstract: Embodiments relate to a non-enzymatic glucose sensor. The non-enzymatic glucose sensor comprises one or more electrodes, a microfluidic channel, and at least one inlet, wherein the at least one inlet is configured to deliver a fluid to a microfluidic channel and wherein the microfluidic channel is configured to transport the fluid to the one or more electrodes. At least one of the one or more electrodes is a laser-induced graphene electrode, wherein the laser-induced graphene electrode comprises one or more uniform coatings of metal.

Abstract: The invention provides a manufacturing method for a non-invasive blood glucose monitoring device, which comprises the following steps: providing a substrate; performing an injection molding process or an electroplating process, to form at least one light-blocking wall on the substrate, wherein each light-blocking wall includes a lower wall-structure and an upper wall-structure, and the lower wall-structure connects the substrate and the upper wall-structure connects the lower wall-structure; arranging a light-emitting element and a light-receiving element on the substrate and separating the light-emitting element and the light-receiving element by the at least one light-blocking wall; forming a packaging structure on the substrate in which the light-emitting element and the light-receiving element are packaged; and disposing a transparent cover on the packaging structure and the at least one light-blocking wall and limiting the transparent cover to a configuration height by the at least one light-blocking wal

Abstract: A non-invasive blood glucose monitoring module with high optical transmittance includes a substrate, a first detecting unit and a second detecting unit. The first detecting unit includes a first light source set, a first photosensitive element and first blocking wall structures. The first photosensitive element receives light, with a first wavelength, emitted from the first light source set. The first blocking wall structures are located between the two first light-emitting elements and between the first light source set and the first photosensitive element. The second detecting unit includes a second light source set, a second photosensitive element and second blocking wall structures. The second photosensitive element receives light, with a second wavelength, emitted from the second light source set. The second blocking wall structures are located between the two second light-emitting elements and between the second light source set and the second photosensitive element.

Abstract: Disclosed herein are system, method, and computer program product embodiments for interconnecting a prediction visualization with user medical data for analyzing the impact of personal choices on future glucose levels. The prediction visualization is configured to generate predictions of glycemic impact based one or more inputs including choices involving diet and exercise and user medical data, such as the user's historical and current glucose levels. The prediction visualization is configured to be adjustable based on user input and the visualization is configured to dynamically update based on user input. The disclosed interface allows the user to adjust the sequencing of these decisions and portion sizes of meal choices and immediately generate new visualizations representing the impact on predicted future glucose levels.

Abstract: The present disclosure provides systems and methods to monitor analytes present in a biological sample of a subject using a piercing element coupled to a support configured to pierce a body surface of the subject, an analyte binding probe on or within the piercing to provide a change in an optical signal when contacting an analyte in the biological sample of the subject, and a detector configured to detect the optical signal.

Abstract: Disclosed herein is a physiological measurement system that can automatically adjust the number of wavelengths used based on the quality of a sensor signal that is reflective of an optical radiation detected at a sensor after tissue attenuation. The signal quality is examined to determine if it is sufficient to support the use of a full set of wavelengths. If it is determined to be insufficient to support the full set, a reduced number of wavelengths is used.

Abstract: The present disclosure includes a connector assembly that is a part of a sensor assembly for collecting patient physiological data. The connector assembly can include a first connector tab with catches, a second connector tab with openings, a retainer with pins, and a circuit board coupled to a cable. Each of the pins of the retainer can include a detent that can engage one of the catches of the first connector tab. The pins can extend through the openings of the second connector tab so that the retainer is coupled to the first connector tab by the detents engaging the catches. The first and second connector tabs can thereby be coupled together to support the circuit board and the cable between the first and second connector tabs.

Abstract: A blood characteristic measurer includes multiple light sources, a light sensor and a processor. The multiple light sources emit multiple beams of light of different dominant lightening wavelength. The light sensor receives multiple reflected light beams due to the reflection of incident light from a skin surface. The processor is electrically coupled to the light sensor and produces the blood characteristic according to reconstructed spectra generated by the multiple reflected light beams and absorption coefficient spectra generated by the skin surface.

Abstract: The present invention discloses a system and method for optimizing diagnostic and therapeutic effects, and comprises diagnostic endovascular invasive device having sensing means and designated to be in a proximity to a target tissue in order to monitor and provide valuable data regarding its biochemical and/or physiological state in vivo and a controller designated to process data received from said sensors in order to produce medical recommendations and/or conclusions.

Abstract: A wearable biosensor for real-time quantification of a biomarker in a biofluid includes at least one functional module. The functional module includes an iontophoresis induction module, a microfluidic layer, a plurality of multimodal biosensors, and a paperfluidic layer.

Abstract: The present disclosure relates to a method for initial calibration of a continuous biological sensor. More specifically, the present disclosure relates a method for initial calibration of a continuous biological sensor, in which generation of initial calibration information based on a wrong initial calibration value may be prevented by determining whether an initial calibration value obtained by using an additional blood gathering-type sensor for the initial calibration is abnormal and generating initial calibration information and in which when the initial calibration value obtained for the initial calibration is abnormal, the initial calibration information may be accurately generated by obtaining an additional initial calibration value to generate the initial calibration information.

Abstract: An apparatus for the extraction and collection of bodily fluids is disclosed. The apparatus includes a housing configured to receive a body part, wherein the housing comprises an upper portion and a lower portion. The housing includes an end cap removably attached to the upper portion of the housing, wherein the end cap comprises a ribbed connector. The housing additionally includes a first aperture located on the lower portion of the housing. The apparatus includes a gasket mechanically attached to the lower portion of the housing. The apparatus includes a suction device fluidically connected to the ribbed connector of the end cap using a hose. The apparatus includes a fluid collection device configured to extract bodily fluids from the body part as a function of the negative pressure environment, wherein the fluid collection device is removably attached to the end cap.

Abstract: An apparatus includes a housing, a fluid reservoir, a flow control mechanism, and an actuator. The housing defines an inner volume and has an inlet port that can be fluidically coupled to a patient and an outlet port. The fluid reservoir is disposed in the inner volume to receive and isolate a first volume of a bodily-fluid. The flow control mechanism is rotatable in the housing from a first configuration, in which a first lumen places the inlet port is in fluid communication with the fluid reservoir, and a second configuration, in which a second lumen places the inlet port in fluid communication with the outlet port. The actuator is configured to create a negative pressure in the fluid reservoir and is configured to rotate the flow control mechanism from the first configuration to the second configuration after the first volume of bodily-fluid is received in the fluid reservoir.

Abstract: A device that assists with correct and efficient collection of capillary blood onto dried blood spot collection (DBS) card. The device may comprise a rectangular shape configured to hold a DBS card in a desired orientation for blood sample collection. The device comprises holes on a top side that are aligned above the circular target spots on the DBS card. The patient will be able to direct drops of capillary blood to pass through the top holes and then blood will travel into the DBS card at precise locations so as to ensure proper saturation while minimizing risk of outside contaminants and/or cross-contamination between target spots. Further, the patient can verify saturation level by looking through observation orifices disposed on the device.