Tissue Derived From Multicellular Animal (e.g., Connective Tissue, Muscle, Organ, Tendon, Etc.) Patents (Class 106/124.4)
  • Patent number: 9023142
    Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: May 5, 2015
    Assignee: Spiber Inc.
    Inventors: Junichi Sugahara, Kazuhide Sekiyama, Ryota Sato, Kaori Sekiyama, Mizuki Ishikawa, Shinya Murata, Kazuko Otomo
  • Patent number: 8979992
    Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: March 17, 2015
    Assignee: Spiber Inc.
    Inventors: Junichi Sugahara, Kazuhide Sekiyama, Ryota Sato, Kaori Sekiyama, Mizuki Ishikawa, Shinya Murata, Kazuko Otomo
  • Publication number: 20150047532
    Abstract: A method for solubilizing recombinant spider silk proteins in an aqueous solutions, where the method includes mixing recombinant spider silk proteins with water to form a mixture and heating the mixture in a closed vessel to form a solution.
    Type: Application
    Filed: August 13, 2014
    Publication date: February 19, 2015
    Inventors: Randolph V. Lewis, Justin A. Jones
  • Publication number: 20150050436
    Abstract: A substantially non-elastic incompressible composition, which substantially does not quickly self-level under standard operating conditions, includes: a suspending agent which reacts substantially as a solid when subjected to forces below a critical force, and which becomes substantially flowable when subjected to forces above said critical force. Aspects include compositions comprising one or more of ceramic microparticulates, flexible-walled microparticulates, celled macroparticulates, and fibers dispersed within the suspending agent, and energy absorbing applications thereof. Another aspect comprises thin-walled macrospheres containing a substantially non-elastic incompressible composition.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 19, 2015
    Inventor: Joel L. Sereboff
  • Patent number: 8858698
    Abstract: An acellular matrix glue and a method of making is disclosed. Specifically, an acellular matrix glue that is useful in preparing a reinforced acellular matrix for medical applications including tissue engineering and hernia repair.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: October 14, 2014
    Assignee: Mentor Worldwide LLC
    Inventors: Chunlin Yang, Thomas Matalenas, Raymond S. Shissias, Kerstin Spychaj
  • Patent number: 8808442
    Abstract: Hydraulically applied fiber matrix compositions for use on soils include a water-soluble, crosslinkable, hydratable gum, and a compound capable of crosslinking the water-soluble, crosslinkable, hydratable gum. The compositions may further include hydrocolloids and mulch. The hydraulically applied fiber matrix compositions are useful for hydroseeding and soil stabilization.
    Type: Grant
    Filed: November 9, 2010
    Date of Patent: August 19, 2014
    Assignee: Chemstar Products Company
    Inventors: Cory J. Bernu, Jeremy L. Bachman, Paul F. Werler
  • Publication number: 20130280523
    Abstract: The invention relates to a coating composition containing between 51 wt % and 99.9 wt % of a TiO2-producing agent, wherein the coating composition contains between 0.1 wt % and 49 wt %, relative to the total composition, of at least one further component which is selected from collagen, chitosans, phenols and/or substituted quaternary ammonium salts of alkylated phosphoric acid. The invention further relates to a nanoscale coating based on titanium dioxide, and to the production, further processing and use thereof.
    Type: Application
    Filed: July 27, 2011
    Publication date: October 24, 2013
    Inventors: Martin Schwarz, Frank-Hendrik Wurm, Beate Heisterkamp, Ute Bergmann, Silvia Muehle, Hartmut Worch
  • Publication number: 20120202748
    Abstract: The present invention relates to a bio-adhesive derived from mussel. In particular, it relates to a recombinant protein fp(foot protein)-131 that is a hybrid of fp-3 variant A and fp-1. According to the present invention, the recombinant protein with adhesive activity can be economically produced in large scale to be used in place of chemical adhesives.
    Type: Application
    Filed: February 7, 2012
    Publication date: August 9, 2012
    Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Hyung Joon CHA, Dong Gyun KANG, Young Hoon SONG, Yoo Seong CHOI, Seonghye LIM
  • Patent number: 8205623
    Abstract: This disclosure relates to personal grooming apparatus that include coatings on the surface thereof that incorporate calcium carbonate derived from the shell of a mollusk and/or from a mollusk pearl. Other aspects of the present disclosure relate to methods for producing such apparatus, and methods of grooming the hair or skin of an individual.
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: June 26, 2012
    Assignee: Rovcal, Inc.
    Inventor: Maciej Murzynski
  • Patent number: 8137450
    Abstract: A lyophilized glue contains a collagen which is partially crosslinked with the aid of at least one type of aldehyde. A method for preparing the glue and the use thereof for producing an adhesive on anti-adhesive prosthesis are also provided.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: March 20, 2012
    Assignee: Symatese
    Inventors: Bernard Ragaru, Benjamin Herbage
  • Patent number: 7927414
    Abstract: An acellular matrix glue and a method of making is disclosed. Specifically, an acellular matrix glue that is useful in preparing a reinforced acellular matrix for medical applications including tissue engineering and hernia repair.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: April 19, 2011
    Assignee: Ethicon, Inc.
    Inventors: Chunlin Yang, Thomas Matalenas, Raymond S. Shissias, Kerstin Spychaj
  • Publication number: 20110046686
    Abstract: Described herein are methods and compositions comprising a mixture of silk polymer and hydroxyapatite. The methods described herein can be used to prepare a mixture of silk polymer and hydroxyapatite and further provide mixtures that can be molded into a desired shape. Also encompassed herein are compositions comprising a mixture of silk polymer and hydroxyapatite having a desired shape, which can further be implanted, for example, to facilitate bone healing or tooth structure or support. Such compositions can also include agents, such as therapeutic agents, or cells.
    Type: Application
    Filed: February 6, 2009
    Publication date: February 24, 2011
    Applicant: TRUSTEES OF TUFTS COLLEGE
    Inventors: David L. Kaplan, Hyeon Joo Kim, Gerard Kugel
  • Publication number: 20100255447
    Abstract: Disclosed herein are methodologies and compositions for coating materials, which can be used in a variety of biological applications.
    Type: Application
    Filed: October 23, 2009
    Publication date: October 7, 2010
    Inventors: ALEXANDRU S. BIRIS, PEDER JENSEN, GANESH KANNARPADY
  • Publication number: 20080295735
    Abstract: A lyophilised glue contains a collagen which is partially crosslinked with the aid of at least one type of aldehyde. A method for preparing the glue and the use thereof for producing an adhesive on anti-adhesive prosthesis are also provided.
    Type: Application
    Filed: July 7, 2005
    Publication date: December 4, 2008
    Applicant: SYMATESE
    Inventors: Bernard Ragaru, Benjamin Herbage
  • Publication number: 20040005363
    Abstract: A biodegradable biopolymer material consists of silk fibroin from domesticated silkworm; silk fibroin from wild silkworm; a composite material comprising silk fibroin from domesticated silkworm and silk fibroin from wild silkworm; or a composite material comprising either silk fibroin from domesticated silkworm or silk fibroin from wild silkworm and at least one secondary substance selected from the group consisting of cellulose, chitin, chitosan, chitosan derivatives, keratin from wool and polyvinyl alcohol. The material may be prepared by, for instance, casting an aqueous solution of domesticated silkworm silk fibroin on the surface of a substrate and then cast drying the applied solution. The biodegradable biopolymer material is effectively used as, for instance, a metal ion-adsorbing material, a sustained release substrate for a useful substance such as a medicine, a biological cell-growth substrate and a biodegradable water-absorbing material.
    Type: Application
    Filed: June 11, 2003
    Publication date: January 8, 2004
    Applicant: NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES
    Inventors: Masuhiro Tsukada, Takayuki Arai
  • Publication number: 20030224269
    Abstract: The present invention relates to an imaging member comprising poultry gelatin. In one embodiment, the poultry gelatin is located preferably in at least one layer in the upper half of said imaging member comprising poultry gelatin. Another embodiment provides an aqueous coating composition comprising poultry gelatin.
    Type: Application
    Filed: May 8, 2002
    Publication date: December 4, 2003
    Inventors: James S. Honan, Andrew M. Howe, Paul A. Corbelli, Lloyd A. Lobo, Ryan B. Adams, John S. Brand
  • Publication number: 20030047110
    Abstract: A non-synthetic biodegradable starch-based composition is described comprising starch, plasticizer, reinforcing filler, binder, in the presence or absence of alkali or salt, and water. The starch-based composition is subjected to transformation process to produce various foam-liked products, having closed cell structure with dense skin layer. These products are particularly suitable for use as disposal or single-used food packages or containers. These products are to substitute the shape bodies currently used made of plastic or plastic foam. A transformation process of the non-synthetic biodegradable starch-based composition into various foam-liked products is also described. The process is either injecting or compressing the starch-based composition and forming a desired shape in a closed mould at a temperature ranging from 150 to 300 degree Celcius until the gelatinization of starch has been accomplished.
    Type: Application
    Filed: October 29, 2002
    Publication date: March 13, 2003
    Inventors: Ngamtip Poovarodom, Saisanom Praditdoung
  • Publication number: 20010034336
    Abstract: Coatings are provided in which biopolymers may be covalently linked to a substrate. Such biopolymers include those that impart thromboresistance and/or biocompatibility to the substrate, which may be a medical device. Coatings disclosed herein include those that permit coating of a medical device in a single layer, including coatings that permit applying the single layer without a primer. Suitable biopolymers include heparin complexes, and linkage may be provided by a silane having isocyanate functionality.
    Type: Application
    Filed: May 23, 2001
    Publication date: October 25, 2001
    Inventors: Chirag B. Shah, Laurel L. Wolfgang