Tartrate Containing (e.g., Rochelle Salt) {c30b 29/56} Patents (Class 117/926)
  • Patent number: 7713351
    Abstract: The objective of the invention is a crystallizing method for macromolecules, especially proteins and polypeptides, in which selected polysaccharides of biological origin, such as alginate, pectin, dextrin or chitosan and hydrolysates thereof, are used as reagents. Sedimentation of the crystals can be prevented and thus the uniformity of the product contributed with the method. The method can be used to prepare new crystal forms of the polypeptide and to improve the stability of crystals.
    Type: Grant
    Filed: January 11, 2005
    Date of Patent: May 11, 2010
    Assignee: Macrocrystal Oy
    Inventors: Kalevi Visuri, Sinikka Uotila, Katja Palmunen
  • Patent number: 7470324
    Abstract: A method for the crystallization of macromolecules in a three-phase system using a vessel containing a lower aqueous phase, a middle phase and an upper hydrophobic phase having a lower density than that of the lower aqueous phase, wherein an aqueous solution of the macromolecules is added to the middle phase to form a fourth phase, followed by incubation.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: December 30, 2008
    Inventor: Kurt Hoffmann
  • Patent number: 7258745
    Abstract: The present invention comprises a method for fabricating hafnia film comprising the steps of providing a substrate having a surface that allows formation of a self-assembled monolayer thereon via covalent bonding; providing an aqueous solution that provides homogeneous hafnium ionic complexes and hafnium nanoclusters wherein the aqueous solution is capable of undergoing homogeneous precipitation under controlled conditions for a desired period of time at a controlled temperature and controlled solution acidity for desired nanocluster nucleation and growth kinetics, desired nanocluster size, desired growth rate of film thickness and desired film surface characteristics.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: August 21, 2007
    Assignee: UT-Battelle, LLC
    Inventor: Michael Z. Hu
  • Patent number: 7247203
    Abstract: The present invention relates to a process for producing high-quality crystals of protein or organic substances easily and efficiently. A solution of protein or an organic substance is prepared and then is cooled slowly to be supersaturated to a low degree. This supersaturated solution is irradiated with a femtosecond laser 10. A local explosion phenomenon occurs at the focal point of the laser and thereby a crystalline nucleus is generated. A high-quality crystal is obtained when a crystal is grown on the crystalline nucleus over a long period of time. The femtosecond laser to be used herein can be a titanium:sapphire laser having a wavelength of 800 nm, a duration of 120 fs, a frequency of 1 kHz, and an output of 400 mW.
    Type: Grant
    Filed: August 25, 2003
    Date of Patent: July 24, 2007
    Assignee: Osaka Industrial Promotion Organization
    Inventors: Takatomo Sasaki, Yusuke Mori, Masashi Yoshimura, Hiroaki Adachi, Hiroshi Masuhara, Youichiroh Hosokawa, Kazufumi Takano
  • Patent number: 7232486
    Abstract: Provided is a method for crystallization and purification of a macrolide such as tacrolimus, sirolimus, pimecrolimus, or everolimus that includes the step of providing a combination of a macrolide, and a polar solvent, dopolar aprotic solvent, or hydrocarbon solvent at pH of 7 or above.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: June 19, 2007
    Assignee: TEVA Gyógyszergyár Zártkörűen Működő Részvénytársaság
    Inventors: Vilmos Keri, Andrea Csorvasi
  • Patent number: 7166161
    Abstract: The present invention relates to an anisotropic films and method for obtaining the same. The film comprises substrate and at least one modified conjugated aromatic crystalline layer deposited onto said substrate. The said layer is characterized by globally ordered crystalline structure with intermolecular spacing of 3.4±0.3 ? along one of optical axes. The modified conjugated aromatic crystalline layer is formed by rodlike supramolecules, which comprise at least one polycyclic organic compound with conjugated ?-system. At least part of the modified conjugated aromatic crystalline layer has electric conductivity and is slightly soluble or insoluble in polar solvents. The films are useful in optical applications, such as polarizers and retarders, and in electronic and light emitting devices, such as fiber optics modulators and switches, solar cells, charge-coupled device (CCD), thin film transistor integrated circuits, light emitting diodes, and light emitting displays.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: January 23, 2007
    Assignee: Nitto Denko Corporation
    Inventors: Pavel I. Lazarev, Victor V. Nazarov
  • Patent number: 6955717
    Abstract: The present invention provides machine readable media embedded with the three-dimensional atomic structure coordinates of Synagis Fab, and subsets thereof, and methods of using them.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: October 18, 2005
    Assignees: Medimmune Inc., Bowie State University
    Inventors: Leslie S. Johnson, Bradford Braden
  • Patent number: 6840999
    Abstract: Amorphous or polycrystalline films have been recrystallized into single-crystal thin films (of micrometer thickness) by a zone melting technique, in which an electrically heated wire generated a narrow heated or molten zone (0.5-2 mm wide) on the substrate sandwiched between two pieces of glass or indium-tin-oxide-coated glass. The substrate can be either an organic or inorganic compound. When the molten zone was moved slowly (3-120 ?m/min) across the layer from one end of the cell to the other, a single-crystal film was produced after a single pass. This technique allows for thin film purification and an improvement in electronic, optical, and optoelectronic properties of the thin film. After this treatment, the steady-state short-circuit photocurrent can be improved by several orders of magnitude. These films are useful in the fields of optics and electronics for improving the performance in devices such as thin-film transistors and organic light-emitting diodes.
    Type: Grant
    Filed: July 16, 2001
    Date of Patent: January 11, 2005
    Assignee: Board of Regents The University of Texas System
    Inventors: Chongyang Liu, Allen J. Bard
  • Patent number: 6837926
    Abstract: A microfluidic device is provided that comprises: a card shaped substrate having first and second opposing faces; one or more microvolumes at least partially defined by a first face of the card shaped substrate; and one or more grooves at least partially defined by a second face of the card shaped substrate; wherein a lateral footprint of at least a portion of the one or more grooves overlaps with a lateral footprint of at least one of the one or more microvolumes.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: January 4, 2005
    Assignee: Syrrx, Inc.
    Inventor: Peter R. David
  • Patent number: 6821339
    Abstract: The invention relates to a process for the crystallization of substances having a narrow metastable supersaturation zone. In the process the saturation of a solution is gradually increased and the solution is seeded for the crystallization. The seeding is performed at a seeding point which is selected in response to a signal received from said process indicating imminent or initial spontaneous nucleation. The process provides a good crystal yield and a crystalline product having a uniform crystal structure and a narrow crystal size distribution.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: November 23, 2004
    Assignee: Finnfeeds Finland Oy
    Inventors: Kristian Eriksson, Juha Nurmi, Jouko Virtanen
  • Patent number: 6770133
    Abstract: A homogeneous crystal having excellent stability which is suitable for the industrial-scale production of 5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide (KRP-297). The novel crystal of KRP-297 is produced through recrystallization from an alcohol solvent. It is characterized by having diffraction angles (2&thgr;) at at least 9.7°, 15.0°, and 22.5° in X-ray powder diffractometry.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: August 3, 2004
    Assignee: Kyorin Pharmaceutical Co., Ltd.
    Inventors: Michiro Ohnota, Kazuo Orita
  • Patent number: 6752868
    Abstract: A three dimensional photonic crystal and layer-by-layer processes of fabricating the photonic crystal. A templated substrate is exposed to a plurality of first microspheres made of a first material, the first material being of a type that will bond to the templated substrate and form a self-passivated layer of first microspheres to produce a first layer. The first layer is exposed to a plurality of second microspheres made of a second material, the second material being of a type that will bond to the first layer and form a self-passivated layer of second microspheres. This layering of alternating first and second microspheres can be repeated as desired to build a three dimensional photonic crystal of desired geometry.
    Type: Grant
    Filed: July 31, 2002
    Date of Patent: June 22, 2004
    Assignee: MCNC Research & Development Institute
    Inventors: John South Lewis, III, Scott Halden Goodwin-Johansson, Brian Rhys Stoner, Sonia Grego, David Edward Dausch
  • Patent number: 6743290
    Abstract: Disclosed are compositions comprising one or more undecamantanes. Specifically disclosed are compositions comprising 25 to 100 weight percent of one or more undecamantanes. Also disclosed are novel processes for the separation and isolation of undecamantane components into recoverable fractions from a feedstock containing at least a higher diamondoid component which contains one or more undecamantane components.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: June 1, 2004
    Assignee: Chevron U.S.A. Inc.
    Inventors: Jeremy E. Dahl, Robert M. Carlson
  • Patent number: 6022409
    Abstract: A method of optical enantiomer resolution by preferential crystallization involves entering, each time crystallization starts, the two-phase domain containing excess enantiomer and the saturated solution, and cooling according to a well-defined kinetic schedule. A racemic mixture of fine particle size is added to the mother liquors obtained after harvesting the crystals, the mother liquors then being heated to a temperature lower than that of homogenization of the solution so that excess enantiomer is present only in a solid state in equilibrium with the solution. Further cooling produces the other enantiomer and completes the cycle of operations which may then be carried out repetitively.
    Type: Grant
    Filed: October 2, 1996
    Date of Patent: February 8, 2000
    Assignee: The University of Rouen
    Inventors: Gerard Coquerel, Marie-Noelle Petit, Roger Bouaziz
  • Patent number: 6017390
    Abstract: The present invention relates to methods and compositions for the growth and alignment of crystals at biopolymeric films. The methods and compositions of the present invention provide means to generate a variety of dense crystalline ceramic films, with totally aligned crystals, at low temperatures and pressures, suitable for use with polymer and plastic substrates.
    Type: Grant
    Filed: July 22, 1997
    Date of Patent: January 25, 2000
    Assignee: The Regents of the University of California
    Inventors: Deborah H. Charych, Amir Berman
  • Patent number: 6001176
    Abstract: A device for specific formation of nuclei or crystals on the surface of a dielectric in contact with a solution, especially on the functional groups of a polymer, in which there is a device for generating an electric field in the dielectric.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: December 14, 1999
    Assignees: Klaus Leiter, Gerhard Walder
    Inventors: Klaus Leiter, Gerhard Walder
  • Patent number: 5738720
    Abstract: The present invention aims to provide a method of manufacturing a microstructure pattern of a high orientation aggregate of organic molecular material by forming a fine pattern made by single crystal growing ionic material of another property on an ionic substrate by lithography and epitaxial growth, and forming a pattern made by organic molecular material having functionability to light on the fine pattern by utilizing dependence of substrate material of crystal growth rate in epitaxial growth, and is applied to the formation of a microstructure pattern of organic molecular material which can be utilized for optical waveguide, optical integrated circuit, non-linear optical element and laser resonator.
    Type: Grant
    Filed: February 12, 1996
    Date of Patent: April 14, 1998
    Assignee: The University of Tokyo
    Inventors: Toshihiro Shimada, Atsushi Koma
  • Patent number: 5554220
    Abstract: In a method using organic vapor phase deposition (OCPD), for the growth of thin films of optically nonlinear organic salts, a volatile precursor of each component of the salt is carried as a vapor to a hot-wall reaction chamber by independently controlled streams of carrier gas. The components react to form a polycrystalline thin film on substrates of glass and gold. Excess reactants and reaction products are purged from the system by the carrier gas. For example, the method provides the growth of polycrystalline, optically nonlinear thin films of 4'-dimethylamino-N-methyl-4-stilbazolium tosylate (DAST) with >95% purity.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: September 10, 1996
    Assignee: The Trustees of Princeton University
    Inventors: Stephen R. Forrest, Vladimir S. Ban, Paul E. Burrows, Jeffrey Schwartz