Abstract: Systems and methods are provided for delivering one or more drugs. In some embodiments, a drug delivery system includes a housing having a distal end with an inlet through which an inspiratory flow of air passes into the housing, a proximal end having a patient interface attached thereto, the patient interface being configured to interface with a user, and an inspiratory flow pathway extending from the distal end to the proximal end of the housing. A nitric oxide (NO) source is positioned within the housing and is configured to deliver NO-containing gas to the patient interface. A secondary drug source is positioned within the housing and is configured to deliver a secondary drug to the patient interface. A controller is configured to control an amount of NO-containing gas and an amount of the secondary drug delivered using a control scheme.

Abstract: An aerosol generating system including a housing defining an airflow outlet; a liquid aerosol-forming substrate; an aerosol generator, configured to generate an aerosol from the liquid aerosol-forming substrate; a perforated plate disposed between the aerosol generator and the airflow outlet, the perforated plate defining a plurality of apertures extending through the perforated plate; and an electrode disposed between the aerosol generator and the perforated plate, wherein the perforated plate is electrically conductive, and wherein the electrode and the perforated plate are configured to generate an electrical potential.

Abstract: A portable rechargeable personal ionic air purifier energizing a personal airspace and cleaning particulate pollutants therefrom provides removable attachment of ion emitter and housing subassemblies by magnetic attraction, provides an electrically grounded conductive member external to the housing that releasably clips a lanyard or article of clothing, includes a decorative surround and provides an external ground plate for use with a desktop mount, armband or other accessory.

Abstract: Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

Abstract: Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.

Abstract: The present invention is a compact and portable personal ultraviolet air irradiation system having an ultraviolet air irradiation unit, a breathing tube, and a face mask. Unfiltered air passes through the ultraviolet air irradiation unit and is purified to ensure biological material has been neutralized by utilizing UV LEDs in the germicidal wavelengths of 100-280 nm. The ultraviolet air irradiation unit may further purify air of air particulates, gases, vapors, and biological material by utilizing a HEPA filter. The ultraviolet air irradiation unit may provide variable pressure to the mask to meet the breathing demands of the user. Flow through the ultraviolet irradiation unit may be reversible to irradiate the exhalations of a user who may be infected with a virus or other disease spread through exhalations.

Abstract: A system and method for an antivirus and radiation detection system configured to protect a wearer is provided. The system includes a personal protective equipment for preventing respiratory infection that includes a body configured to cover a nose and mouth of the user the body including at least one filter element disposed in the body that allows air to pass through the filter element from a first side of the body to a second side of the body; the filter element having a filter media; an ultraviolet light element disposed in the filter element that provides ultraviolet light into the filter media; and a pulsing laser element disposed in the filter element.

Abstract: Devices and systems provide methods of controlling breathable gas generation such as for a respiratory treatment and/or for controlling ionization of the gas. In an example, a controller of a respiratory treatment apparatus controls generation of a supply of ionized air. The apparatus may include a flow generator to generate a flow of pressurized breathable gas. The flow generator may be adapted for connection with a respiratory interface. The apparatus may also include an ionizer to ionize the flow of gas. The controller may be coupled with the ionizer and the flow generator and be configured to control the ionizer to programmatically change levels of ionization of the gas. Such ionized gas treatments may be suitable for helping users to sleep or improving respiratory oxygen absorption, and may be for patients with, for example, sleep disordered breathing or chronic obstructive pulmonary disease.

Abstract: A dry powder inhaler may include a powder storage, an inlet channel, a dispersion chamber, and an outlet channel. A geometry of the inhaler may be such that a flow profile is generated within the dispersion chamber that causes an actuator to oscillate, enabling the actuator when oscillating to deaggregate powdered medicament within the dispersion chamber to be aerosolized and entrained by the air and delivered to a patient through the outlet channel.

Abstract: A powder for delivery to the oral cavity of a user is disclosed. The powder includes at least two populations of particles. A first population of particles includes a stimulant, and a second population of particles includes a flavorant. Also described is a cartridge containing the powder for use in an inhaler device and inhaler device containing the powder.

Abstract: Devices and systems provide methods of controlling breathable gas generation such as for a respiratory treatment and/or for controlling ionization of the gas. In an example, a controller of a respiratory treatment apparatus controls generation of a supply of ionized air. The apparatus may include a flow generator to generate a flow of pressurized breathable gas. The flow generator may be adapted for connection with a respiratory interface. The apparatus may also include an ionizer to ionize the flow of gas. The controller may be coupled with the ionizer and the flow generator and be configured to control the ionizer to programmatically change levels of ionization of the gas. Such ionized gas treatments may be suitable for helping users to sleep or improving respiratory oxygen absorption, and may be for patients with, for example, sleep disordered breathing or chronic obstructive pulmonary disease.

Abstract: A system for removing microorganisms from a surface is described. The system includes a conducting member, a voltage source, and an electrostatic field controller. The conducing member includes a nonwoven material incorporating conductive fibers. The controller is electrically connected to the conducting member and is configured to apply a DC voltage of about 15 volts or less to the conducting member via the voltage source. The surface to be contacted can include any surface present in households, food industry facilities, medical facilities, etc. Such surfaces can include tables, countertops, walls, cabinets, doors, door handles, door knobs, etc. The system can also be used to treat devices used in the aforementioned environments, such as food preparation equipment, medical devices, household appliances, etc. The system can reduce the amount of microorganisms on the surface by at least about 1 log (90%) without the use of chemicals, high voltages, or long exposure times.

Abstract: A protective device protects the user from infection and may simultaneously immunize the user against future infection. In an embodiment, the protective device includes a disinfection chamber wherein the chamber is arranged to disinfect and/or sterilize fluid in the chamber prior to discharge of the fluid from the chamber such that the fluid discharged from the chamber comprises inactive microorganisms. The device may include a disinfection chamber in fluid communication with a face mask, with the chamber arranged to disinfect and/or sterilize fluid in the chamber prior to discharge of the fluid from the chamber to the mask, such that the fluid discharged from the chamber to the mask comprises inactive microorganisms.

Abstract: A control system for multiple sterilization chambers for the sterilization of medical and other instruments interact with a common vacuum pump, steam generator and ozone generator via a common controller. Instead of placing all instruments of one type in one large chamber and running one generic sterilization program followed by another such program, instruments may be grouped by the type of sterilization program needed and the sterilization programs may be run using a single pump and a single ozone generator fed into multiple sterilization chambers controlled by the controller. One smaller and less expensive vacuum pump and ozone generator may be sufficient to sterilize large amounts of medical equipment present in the total assembly of chambers. The controller may run sterilization programs in parallel fully or overlapping partially in time. Control valves governing flow passage of air, steam and ozone in and out of the chambers are also controlled by the controller.

Abstract: An ozone device for deodorizing dresses within a closet, includes an ozone generator. The ozone generator includes a casing formed with first and second ventilation vents, an ozone producing element installed within the casing for generating ozone in order to deodorizing dresses within the closet, a circulating fan installed within the casing for circulating ozone generated by the ozone producing element, and a hanging unit projecting outward from the casing and adapted to be hung onto a suspension member. The closet is sleeved over and cooperates with the casing to define a sealed chamber so that dresses can be kept therein.

Abstract: An apparatus for disinfecting surfaces and in particular human and animal wounds, includes a contractor for accumulating concentrated ozonated water and systems to deliver ozonated water from the reservoir to a nozzle having one or more jets for delivering a spray of ozonated water on to the surface to be treated. The nozzle has an encircling shroud and systems are provided for withdrawing ozonated gas liberated at the nozzle from around the nozzle. A collection tray is provided which is located under the surface/wound to be treated to receive ozonated water flowing from the treatment region and where any residual ozone is broken down.

Abstract: A respiratory protection system which is worn by a passenger during a flight in air plane, by a patient visiting hospital or doctors office, a nurse working with a patient during hospital stay, or the like. The system includes a relatively light weight, substantially rigid, headgear structure, containing an air disinfection chamber, a fan means, a filter means, an ultraviolet air disinfection means, an air blanket origination means and an energizing means.

Abstract: An in-structure air delivery system comprises a control panel and a plurality of air delivery lines. The control panel is located at a first location in the structure and has an air supply inlet. Each air delivery line extends from the control panel to a different location in the structure. Valves are configured to selectively control the flow of air through each of the air delivery lines. In a method of use, a high pressure air supply such as a portable compressor is connected to the inlet of the system. Air is selectively delivered to one or more of the delivery lines. A control unit is connected to the outlet of the delivery line. Air is supplied to the control unit. The control unit is used to regulate the flow of air to a component of breathing equipment, such as to a firefighter's breathing equipment air cylinder to be re-filled.

Abstract: Apparatuses, systems and methods for generating, dispersing and delivering chemical compounds utilizing desorption electrospray ionization. Embodiments include an airflow channel into which an airflow is directed, a solvent reservoir containing a volume of solvent, at least one charged droplet source for producing a plurality of charged liquid droplets in the channel, and at least one grounded counter electrode positioned within the channel with the electrodes having at least one surface containing one or more chemical compounds that include releasable ions. In operation, the charged droplets are directed onto the surface or surfaces so that the impact of the charged particles on said surface produces gaseous ions of at least one chemical compound on said surface, after which the gaseous ions are dispersed into the airflow.

Abstract: The present invention is directed to a treatment method and system that (a) while controlling ozone production, electrically charges a plurality of (i) atomic particles (e.g., diatomic oxygen and water molecules) and/or (ii) electrically charged droplets in an input gas stream to form a charged gas stream and (b) provides the charged gas stream to a living organism to be treated.

Abstract: A self-contained open-circuit breathing apparatus for use within a body of water naturally containing dissolved air. The apparatus is adapted to provide breathable air to a diver. The apparatus comprises an inlet means for extracting a quantity of water from the body of water. It further comprises a separator for separating the dissolved air from the quantity of water, thereby obtaining the breathable air. The apparatus further comprises a first outlet means for expelling the separated water back into the body of water, and a second outlet means for removing the breathable air and supplying it for breathing. The air is supplied so as to enable all of it to be expelled back into the body of water after it has been breathed.

Abstract: The invention relates to a therapy device for the specifically local treatment and curing of colds in the region of the nose, frontal sinus and throat area in human beings. The external appearance of the therapy device can resemble that of a common hair dryer or face sauna, but the therapy device also contains a means for reducing or suppressing HF radiation (electrosmog) which is normally emitted towards the external environment. According to the invention, a body made of crystallized salt, especially from a natural source, resulting in negative ionization of the heated air flow, is arranged in the region of the heated air flow prior to the exit thereof from the small, handy device. The body is cross-flown by the heated air flow or is at least touched thereby. The treatment of colds with the aid of said therapy device is based on the fact that cold viruses, i.e., primarily rhino viruses and corona viruses, can be eliminated by active treatment with a heated air flow.

Abstract: Apparatus and a concomitant method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate and a charge accumulation control circuit for computing the amount of charge accumulated upon the substrate and deactivating the emitter when a selected quantity of charge has accumulated. Additionally, a triboelectric charging apparatus charges the medicament powder and forms a charged medicament cloud proximate the charged region of the substrate. The medicament particles within the medicament cloud electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate at the predefined region and the charge-to-mass ratio of the medicament powder in the cloud control the amount (dose) of medicament deposited and retained by the substrate.

Abstract: An ultrasonic dosage device having an enclosure for providing a medication in the form of a nebulized mist, including an energy source positioned within the enclosure and a vibration device with a switch for applying electrical energy from the energy source to the vibration device. An assembly is attached to the enclosure and has a membrane disposed between the vibration device and the medication for containing the medication and maintaining the medication in contact with the vibration device only by way of the membrane, whereby the membrane is vibrated and the medication is thereby converted into the mist by vibrations transmitted to the medication by way of the membrane when power is applied to the vibration device.

Abstract: A pulmonary drug delivery device includes a hand piece that is electrically connected to a control unit. A cartridge is engagable with the hand piece and includes a drug reservoir, a pump connected to the drug reservoir, an electrically chargeable nozzle connected to the pump, a discharge electrode, and an information storage element. The control unit controls the pump and the electrical charge of the nozzle and discharge electrode in accordance with instructions stored within the information storage element.

Abstract: A device for removing airborne contaminants and inhaled biopathogens, particularly particulate or aerosol contaminants, from respired air that can be either stationary or incorporated into a garment or accessory worn upon the body. In a preferred embodiment, the device provides multiple levels of protection against inhalation of a dangerous airborne contaminant. In a preferred embodiment, a negative electrode of a portable power supply such as a battery is connected to voltage multiplier and modulation circuit and than to a discharge electrode having an electron emissive surface disposed near the wearer's airway such as, for example, on a chin guard disposed in front of the airway. The positive (counter) electrode is similarly disposed away from the airway such as, for example, near the forehead, but is electrically insulated from the wearer's body.

Abstract: A nebulizer for delivering a drug to a patient includes an electronic control unit, a hand piece connected to the electronic control unit via a cable, and a cartridge detachably engaged with the hand piece. The electronic control unit includes a controller, a cartridge reader, a dosage storage element, and a display. The display preferably displays the drug name and the number of dosages remaining in the cartridge. The cartridge includes a head or nebulizer element for creating a fine mist or cloud of the drug in droplet form. The cartridge also includes a storage container containing a drug and a pump for pumping the drug to the nebulizer element. The cartridge also contains an information storage element for containing information regarding the drug and the drug delivery protocol for the patient. The information in the information storage element is transmitted to the electronic control unit when the cartridge is engaged with the hand piece.

Abstract: A dry powder, for example, a medicament for an inhaler, comprises elongated particles with an aspect ratio sufficient to cause the particles to be bound to a preferably metal or non-metallic sheet material substrate at the particle tips by electrostatic deposition and for aligning a plurality of particles with their major axes aligned normal to the, substrate and oriented tip-to-tip. Particles deposited form a low density, high relative void deposition to minimize attractive forces between the particles. This minimizes agglomeration and bonding forces to the substrate facilitating the release of a powdered medicament in an inhaler. Medicament dosages in a substrate pocket are covered by a sealing layer. An embodiment of a drug dosage inhaler substrate and inhaler is disclosed.

Abstract: This invention relates to an inhalation apparatus for dispensing an inhalable substance and, in particular, but not exclusively, to an apparatus for use in the delivery of therapeutic substances to the human lung. There is provided and apparatus for dispensing an aerosol of electrostatically charged droplets including a housing having an open end duct in which are located a first electrode having an upper surface lying in a generally longitudinal plane of the duct and a second electrode spaced from the first electrode. The apparatus further includes means for delivering a metered quantity of liquid to the upper surface of the first electrode for atomization, and charging means for applying a higher potential to the second electrode with respect to the first electrode to effect atomization.

Abstract: A method for chemical modification of mammal urine and mammal blood is disclosed.

Abstract: A handy oxygen generator containing an oxygen generating agent which reacts with water to evolve oxygen can arbitrarily supply plenty of oxygen under all circumstances at any time. The oxygen generator can be efficiently used particularly in life-threatening emergencies such as a fire and other accidents or when climbing a mountain or playing a sport. The oxygen generator may be formed of a sealed container partitioned into two chambers separately containing water and the oxygen generating agent, so that the separately contained oxygen generating agent and water can be mixed to react with each other by easily breaking the partition with an external pressure force. The oxygen generator containing beforehand the water along with the oxygen generating agent is very convenient to carry because it has no need of procuring water.