Abstract: The present invention relates to an Breath actuated inhaler (BAI) actuator, comprising: a loading element capable of being loaded with an actuation force, a breath actuated trigger mechanism arranged to counteract the actuation force of the loading element, and to fire the actuator by releasing the actuation force of the loading element in response to an inhalation breath, and actuation locking means moveable between a locked position wherein it relieves the actuation force from the trigger mechanism setting the trigger mechanism in a neutral position, and an armed position wherein the trigger mechanism is set in an armed position.

Abstract: A face mask (10) mechanically coupled to a lung demand valve (LDV) (12). The face mask (10) comprises a main mask and an inner mask (15) which fits over the wearer's mouth and nose. The interior of the inner mask (15) is in fluidic communication with the interior of the main mask (10) by means of non-return valves (16). The interior of the main mask is in fluidic communication with an inlet port (18) which is mechanically and fluidically coupled to a supply port (20) of an LDV. The LDV (12) includes a diaphragm and a cover (44) which comprises three parts (44a, 44b) and (44c). Exhaled air is used to flush the space around the diaphragm. Thus, any toxic or undesirable gas in the vicinity of the diaphragm is pushed out to atmosphere by the exhaled air flowing past and around the diaphragm.

Abstract: A Discontinuous Positive Airway Pressure (DPAP) device and method of using the same for reducing sleep disordered breathing events, such as sleep apnea and snoring. The DPAP device provides selective excitation to the pharyngeal conduit or another muscle or cartilage along the respiratory path, a predetermined period of time before the end of the expiration stage, in order to prematurely reverse the respiratory cycle before the total collapse of the pharyngeal conduit, thus enabling the inhalation stage to reopen and refill the pharyngeal conduit.

Abstract: In one aspect, a respiration system includes a regulator including an inlet for connection to a source of pressurized gas (which includes oxygen) and an outlet for delivery of the gas to the user, and a respiration facepiece for use in connection with the regulator. The facepiece includes an interface to which the regulator is removably attachable, at least one seal system to form a sealing engagement with the face of a user to encompass the nose and mouth of a wearer, an inhalation port in fluid connection with the regulator interface and in fluid connection with the interior of the facepiece, at least one inhalation check valve in fluid connection between the inhalation port and the interior of the facepiece; an exhalation port in fluid connection with the facepiece; an exhalation check valve in fluid connection with the exhalation port; and an ambient port separate from the inhalation port and from the exhalation port.

Abstract: A respiration system includes a pressure regulator including a housing, an inlet for connection to a pressurized gas comprising oxygen, and a first data communication system, and a respiration facepiece including an interface to which the pressure regulator is removably attachable, at least one seal system to form a sealing engagement with the face of a user to encompass the nose and mouth of a wearer; an inspiration port in fluid connection with the pressure regulator interface and in fluid connection with the interior of the facepiece and at least one display within a volume of sealing engagement with the face of the user that is within the field of view of the user. The pressure regulator interface includes a second data communication system to receive data from the first data communication system to control the at least one display. A sealing attachment may, for example, be formed between the pressure regulator and the interface of the facepiece.

Abstract: A mouthpiece supply valve which may be used in connection with a rebreather. An exemplary mouthpiece supply valve may include a housing, an inlet mushroom valve, an outlet mushroom valve, a supply gas regulator, an exhaust valve, and a mode selector. An exemplary mouthpiece supply valve may perform manual diluent valve, automatic diluent valve, overpressure relief valve, excess fluid ejection, and bail-out valve functions.

Abstract: A system for intermittent delivery of an aerosolized medicament is disclosed. The system may include an aerosol generator, a controller and a conduit. The aerosol generator may be configured to aerosolize a medicament. The controller may be configured to receive physiological characteristic information about a patient, and control the aerosol generator based at least in part on the physiological characteristic information. The conduit may be configured to supply the aerosolized medicament to the patient's airway.

Abstract: An emergency oxygen supply system for use on aircraft in the event of a loss in cabin pressure is configured for delivering allotments of oxygen and timing the delivery such allotments to each passenger so as maximize the efficiency of the transfer of such oxygen into the passenger's bloodstream. The delivery of each allotment is selected so that the entire allotment is available for inhalation into the region of the lung most efficient at oxygen transfer while the volume of the allotment is selected to substantially coincide with the volume of such region of the lung.

Abstract: The present invention relates to an integrated sleep diagnosis and treatment device, and more particularly to an integrated apnea diagnosis and treatment device. The present invention additionally relates to method of sleep diagnosis and treatment.

Abstract: Methods for easing the duration of pain experienced by patients during a cluster headache are disclosed including providing a high-pressure source of substantially pure oxygen, applying the oxygen to the patient so that inhalation by the patient is substantially limited to inhalation of the substantially pure oxygen, inhaling the substantially pure oxygen in order to cause hyperventilation by the patient, and continuing hyperventilation at least until the patient achieves respiratory alkalosis, hypocapnia hyperoxia, and until the pain is terminated. The method preferably includes using a demand valve having a predetermined manual purge flow rate and a variable output flow rate to the user based on respiratory demand.

Abstract: Fluid flow regulators and fluid conservers are disclosed. An exemplary fluid conserver may be operated in one of an intermittent mode of operation and a continuous mode of operation. Further, the exemplary conserver provides at least two pulses of fluid in response to a first trigger, such as the inhalation of a patient.

Abstract: A vent assembly for use with a respiratory mask of the type used in CPAP treatment includes a porous disk portion that is attached to a biasing member such that the disk portion is maintained in a substantially sealed position against a main vent to minimize airflow through at least one side vent of the vent assembly. Debris build-up on the disk portion can cause the biasing member to deflect to provide an additional path for airflow through the at least one side vent. In another embodiment, the vent assembly can also include an anti-asphyxia feature to provide an airflow path from the environment to the user. An oxygen diverter valve may be disposed between the breathing apparatus flow generator and an oxygen injection port.

Abstract: A bi-level pressure support system and method of treating disordered breathing that optimizes the pressure delivered to the patient during inspiration and expiration to treat the disordered breathing while minimizing the delivered pressure for patient comfort. The pressure generating system generates a flow of breathing gas at an inspiratory positive airway pressure (IPAP) during inspiration and at an expiratory positive airway pressure (EPAP) during expirations. A controller monitor at least one of the following conditions: (1) snoring, (2) apneas, (3) hypopneas, or (4) a big leak in the pressure support system and adjusts the IPAP and the EPAP based on the occurrence of any one of these conditions.

Abstract: A gas measurement apparatus can comprise a sensor and a processor, in an example. The sensor can measure a pressure condition of a gas tank, in an example. The processor can select at least one light source, the light source can be positioned or be of a distinct color to indicate a corresponding level of gas remaining in the tank when illuminated. The level of gas can be based on the measured pressure. Banks of high intensity LEDs can allow visually discernable colors at a significant distance underwater. A visual beacon mode can be included. An alphanumeric pressure readout mode can be included. A depth sensor can be included.

Abstract: A double-ended variable speed blower for Continuous Positive Airway Pressure (CPAP) ventilation of patients includes two impellers in the gas flow path that cooperatively pressurize gas to desired pressure and flow characteristics. Thus, the double-ended blower can provide faster pressure response and desired flow characteristics over a narrower range of motor speeds, resulting in greater reliability and less acoustic noise.

Abstract: The invention is a ventilator whose servo-controller adjusts the degree of support by adjusting the profile of the pressure waveform as well as the pressure modulation amplitude. As the servo-controller increases the degree of support by increasing the pressure modulation amplitude, it also generates a progressively more square, and therefore efficient, pressure waveform; when the servo-controller decreases the degree of support by decreasing the pressure modulation amplitude, it also generates a progressively more smooth and therefore comfortable pressure waveform.

Abstract: A breathing apparatus is operable in self-contained and filtered modes of operation. In the self-contained mode of operation, a breathable gas is delivered to a user from a self-contained source of breathing gas. In a second, filtered mode of operation, a suction source draws ambient air through a filter removing contaminants and delivers filtered ambient air to the user. A method of delivering air to a subject is also provided.

Abstract: A flow regulation vent for venting washout gas to atmosphere and for regulating flow from a pressurized gas supply includes a fixed portion adapted to engage a gas supply conduit; a spring force biased movable portion in communication with the pressurized gas supply; and a hinge pivotally connecting the movable portion to the fixed portion. The fixed portion has a gas flow orifice and the movable portion is pivotally movable between 1) a relaxed position, below a specified operating pressure to establish a first gas washout flow area, and 2) a fully pressurized position. At or above the specified operating pressure, the pressurized gas pivots the movable portion adjacent the fixed portion to cover at least a portion of the gas flow orifice and establish a second gas washout flow area. The second gas washout flow area is less than the first gas washout flow area.

Abstract: A gas measurement apparatus can comprise a sensor and a processor, in an example. The sensor can measure a pressure condition of a gas tank, in an example. The processor can select at least one light source, the light source can be positioned or of a distinct color to indicate a corresponding level of gas remaining in the tank when illuminated. The level of gas can be based on the measured pressure.

Abstract: Methods and devices are provided that are effective to remove an obstruction in a human airway related to snoring and/or OSA. In one embodiment, the device includes mouthpiece having a hollow body configured to be disposed in a user's mouth. The body includes superior and inferior outer surfaces as well as anterior and posterior surfaces, a channel configured to receive a user's teeth formed in at least one of the superior and inferior surfaces, an inner cavity formed between the superior, inferior, anterior, and posterior surfaces, and at least one aperture formed in the posterior surface that extends into the inner cavity. In one exemplary embodiment the at least one aperture is oriented to extend away from the user's teeth and toward a user's tongue when the mouthpiece is in use.

Abstract: A system for regulating the airflow to a closed environment using feedback control for the position of a control valve and blower speed. The system provides a control apparatus that regulates airflow to a closed environment, such as the mask of a breathing apparatus, to ensure sufficient breathing air for a wearer of such mask. In order to provide fast response to a change in condition in the breathable environment, the airflow regulator includes a valve control and a blower control.

Abstract: The present invention discloses a method for improving control and detection precision of tidal volume by introducing R value, comprising the steps of: a plateau pressure Pplate is used to calculate a system compliance C with C=?V/(Pplate?PEEP); VT, the tidal volume obtained currently at patient terminal, is calculated with VT=?V×(C?Ctube)/C, wherein ?V is the variation of tidal volume, PEEP is the positive end expiratory pressure and Ctube is the compliance C of the line. Depending on the calculated VT, the tidal volume which is actually obtained by the patients during this period, the processing unit calculates the tidal volume VT?, which the airway is intended to reach during the next expiration period, by VT?=VT+?VT×K wherein K is a scaling factor for control and adjustment, VT is the tidal volume obtained by the patient during the current period, VTset is the presetted tidal volume, ?VT=VTset?VT.

Abstract: A method and device that can vary the dose of a gaseous drug provided to a patient based on a comparison of the normal resting breath rate for each individual patient and the current breath rate of the patient so that the patient does not become desaturated.

Abstract: A method and a CPAP apparatus for characterizing mask systems provided. The CPAP apparatus can be calibrated by including sensors configured to measure flow and pressure. When the flow generator is fitted to a new or changed mask system, a method for calibrating the flow generator for the new or changed mask system. The method includes determining air flow characteristics using flow measurements made during a first test period when the flow through the mask system is open, measuring or estimating pressure in the mask system during a second test period when the flow through the mask system is blocked and determining air flow characteristics of the diffuser of the mask system using the air flow characteristics of the air delivery hose determined during the first test period and the pressure measurements made during the second test period.

Abstract: A ventilator device delivers ventilatory support to a patient in a back up timed mode when patient respiration is not detected or a spontaneous mode when patient respiration is detected. The timing threshold governing the back-up mode is chosen to deviate from normal expected respiration time for the patient to promote patient initiated ventilation in the spontaneous mode but permit back-up ventilation in the event of apnea. Automated adjustments to the timing threshold during the timed mode are made from the less vigilant timing threshold to a more vigilant threshold at or near a timing of normal expected breathing of the patient. Such adjustments may be made from a minimum to a maximum vigilance timing settings or incrementally there between as a function of time in the timed mode which is preferably the number of delivered machine breaths.

Abstract: An alarm system and method for use with a breathing apparatus that provides a source of breathable air to a user/diver. A tactile signal is generated in response to a signal representing at least one parameter corresponding to the breathing apparatus status, and the tactile signal can be both felt and heard by the user. The tactile signal may be generated in combination with a visual and/or an additional audible alarm. The tactile signal may be a vibration. The alarm may be worn on the face, either on the mask or on the mouthpiece. The vibrator serves two functions, one as a tactile alarm that the diver can feel during operation, and a second as an auditory alarm through bone-conduction of sound. The tactile alarm indicates to the user/diver that his particular unit is the one transmitting an alarm signal, and cannot be mistaken for any other device.

Abstract: A pressure demand regulator assembly for use with a breathing apparatus having a valve assembly that includes an inlet for connection to a source of breathing gas, an outlet for connection to a facepiece to provide breathing gas to the user and an actuator for controlling the flow of breathing gas between the inlet and the outlet in response to the user's respiration. The regulator assembly further includes a flexible elastomeric diaphragm in operative connection with the actuator. The diaphragm is exposed to ambient pressure on a first side thereof and exposed to a positive pressure within the facepiece on a second side thereof.

Abstract: A system and method of monitoring a patient, that in one embodiment, comprises determining a flow of gas generated by respiration of the patient, identifying a respiratory event entry and a respiratory event exit based on the flow of gas generated by respiration of the patient, and identifying a respiratory event when the identification of the respiratory event entry is followed by the identification of respiratory event exit.

Abstract: A method for increasing circulation and providing oxygen to a patient in cardiac arrest includes the step of coupling an interface to the patient's airway, the interface providing access to the patient's respiratory system. A valve system is operably attached to the interface. Oxygen is delivered through the interface a rate of between about 1.0 to about 10.0 L/min to provide a continuous supply of oxygen to the patient. While supplying the oxygen, a body structure of the patient is manipulated to increase the magnitude and duration of the patient's negative intrathoracic pressure.

Abstract: Disclosed is a cylindrical, single-component two-stage regulator for controlling a pressure and a flow rate of a gas. The regulator includes a housing for holding the two stages having an ingress adapted for connection to a source of gas at a high input pressure and an egress adapted for supplying gas at a lower output pressure than the high input pressure; a first stage for reducing the pressure of the gas from the high input pressure to a fixed intermediate pressure; and a second stage for reducing the pressure of the gas from the fixed intermediate pressure to the lower output pressure and regulating the flow rate of the gas out of the egress. One application of the present invention is for use in scuba (Self-Contained Under-water Breathing Apparatus) applications, where it replaces the traditional two-component user-adjustable regulator. The regulator may be made out of stainless steel, and is small enough to fit into a user's mouthpiece.

Abstract: A method for acclimating a CPAP therapy patient to a prescribed pressure while the patient falls asleep. During an initial startup period, the CPAP apparatus applies a therapeutic IPAP pressure to the patient's airway and a lower initial EPAP pressure to the patient's airway. The EPAP pressure is ramped up to the IPAP pressure over a sufficient time for the patient to fall asleep. In a modified embodiment, both the initial IPAP pressure and the initial EPAP pressure are less than the prescribed therapeutic pressure. The IPAP and EPAP pressures are then independently ramped up to the prescribed therapeutic pressure.

Abstract: The present invention is a breathing improvement monitor that continuously measures involuntary breathing. The monitor is a sensor apparatus that is attached to a patient's mask which is connected to the monitoring apparatus. The sensor may be reusable and attachable and detachable to a mask or it may be an integral part of a breathing mask. The sensor technology may be any type sufficient in the art, including but not limited to solid state sensors, transducers, electromagnetic microturbines and the like. Since the mask does not have to be removed and the sensor provides constant signal to the monitoring apparatus, a real time status of a patient's involuntary breathing capability may be determined for a doctor's consideration.

Abstract: An apparatus and method for supplying a breathing gas for a respiration. The apparatus includes a reciprocating unit configured to receive an inspiration gas flow and adapted to control respiratory movements. The apparatus also includes a gas mixer for supplying a fresh gas flow. The apparatus also includes a breathing circuit configured to conduct an expiration gas flow to the reciprocating unit and to conduct the fresh gas flow from the gas mixer for the respiration and to conduct the gas flow from the reciprocating unit for an inspiration, the breathing circuit comprising a CO2 remover configured to remove carbon dioxide from the gas. The apparatus also includes a first bypass passage configured to permit bypassing the reciprocating unit and connecting the breathing circuit to the inspiration gas flow upstream from the reciprocating unit.

Abstract: The system and method includes a treatment device such as an anesthetic machine or IV, a monitor and a display configured to display real-time PK/PD data associated with an anesthetic agent administered to the patient. The system and method further includes a safety control means configured to control the display such that one of a basic display state, an interactive effects display state, and a display inhibited state is selected and displayed according to the anesthetic agents and levels of the same being administered to the patient.

Abstract: The present invention is a system and method for integrating anesthesia agent monitoring in a respiratory carestation, wherein the respiratory carestation is configured to be compatible with a variety of monitoring modules. Any one of the monitoring modules is inserted into a module bay, and a sampling line couples the monitoring module to the patient circuit, such that the patient monitoring parameters are displayed on a user interface of the respiratory carestation.

Abstract: A method and a CPAP apparatus for characterizing different mask systems, e.g., masks and hoses, are provided. The apparatus can be calibrated for different mask systems and hoses by including sensors for measuring flow and pressure at a flow generator of the apparatus. When the flow generator is fitted to a new system, or changes are made to an existing system, mask or patient interface, and/or hose, a method of calibrating the flow generator is provided. The method includes determining air flow characteristics of the hose using flow measurements made during a first test period when flow through the system is open, measuring or estimating pressure in the system during a second test period when flow through the system is blocked, and determining air flow characteristics of the diffuser using the air first test period flow characteristics of the air delivery hose and the second test period pressure measurements.

Abstract: A method of controlling an apparatus for separating product gas and non product gas from an air supply, the concentration of the product gas produced by the apparatus being variable depending on a control signal from a controller and the efficiency of the apparatus in producing product gas depending upon an environmental parameter, the method including sensing the oxygen concentration in the product gas produced by the apparatus, determining an instantaneous demand for oxygen concentration in the product gas, providing to the controller a process variable signal indicative of the sensed concentration of the oxygen in the product gas, and providing to the controller a demand input signal indicative of the demand, sensing the environmental parameter and providing an environmental parameter input signal to the controller, comparing the process variable signal and the demand signal to generate an error signal indicative of a change in oxygen concentration in the product gas required to match the instantaneous dem

Abstract: A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 ?g to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.

Abstract: A waterproof structure of a respiratory tube is provided. The waterproof structure comprises a hollow body and a lid. The hollow body has a first opening end and a second opening end opposing to the first opening end. The lid pivots onto the hollow body at the first opening end. Before the lid is immersed into liquid, the gravity of the lid can keep the lid at a certain position so that the respiratory tube is well-ventilated. After a part of the lid is immersed into the liquid, the buoyancy provided by the liquid forces the closing surface thereof to substantially seal the first opening end and prevent liquid from going into the tube.

Abstract: An exhalation valve assembly that controls the pressure of exhaled gas in a ventilation system is described. The exhalation valve assembly includes an actuator module that may be fixed to the ventilation system and a valve module, removable for cleaning or disposal, through which the exhaled gas flows and that controls the pressure and release of the exhaled gas to the environment. Other components may also be incorporated into the assembly including a filter module, a flow meter and a condensate trap.

Abstract: An underwater exhaust system and method which includes an exhaust valve having a sealing edge, an exhaust outlet for exiting an exhaust gas, and a projection for directing water flow away from the exhaust valve. The exhaust valve includes a valve head and a valve stem, the valve stem being coupled with the valve head. The system and method prevent a siphoning effect, whereby leakage of water into the exhaust valve is minimized or prevented.

Abstract: The present invention relates to an integrated sleep diagnosis and treatment device, and more particularly to an integrated apnea diagnosis and treatment device. The present invention additionally relates to methods of sleep diagnosis and treatment. The sleep disorder treatment system of the present invention can use a diagnosis device to perform various forms of analysis to determine or diagnose a subject's sleeping disorder or symptoms of a subject's sleep disorder, and using this analysis or diagnosis can with or in some embodiments without human intervention treat the subject either physically or chemically to improve the sleeping disorder or the symptoms of the sleeping disorder. The diagnostic part of the system can use many different types of sensors and methods for diagnosing the severity of the symptoms of or the sleep disorder itself. The treatment part of the system can use a device to physically or chemically treat the subject's symptoms or sleep disorder itself.

Abstract: A bi-level pressure support system and method of treating disordered breathing that optimizes the pressure delivered to the patient during inspiration and expiration to treat the disordered breathing while minimizing the delivered pressure for patient comfort. The pressure generating system generates a flow of breathing gas at an inspiratory positive airway pressure (IPAP) during inspiration and at an expiratory positive airway pressure (EPAP) during expirations. A controller monitor at least one of the following conditions: (1) snoring, (2) apneas, (3) hypopneas, or (4) a big leak in the pressure support system and adjusts the IPAP and the EPAP independently based on the occurrence of any one of these conditions.

Abstract: Disclosed is a cylindrical, single-component two-stage regulator for controlling a pressure and a flow rate of a gas. The regulator includes a housing for holding the two stages having an ingress adapted for connection to a source of gas at a high input pressure and an egress adapted for supplying gas at a lower output pressure than the high input pressure; a first stage for reducing the pressure of the gas from the high input pressure to a fixed intermediate pressure; and a second stage for reducing the pressure of the gas from the fixed intermediate pressure to the lower output pressure and regulating the flow rate of the gas out of the egress. One application of the present invention is for use in SCUBA (Self-Contained Underwater Breathing Apparatus) applications, where it replaces the traditional two-component user-adjustable regulator. The regulator may be made out of stainless steel, and is small enough to fit into a user's mouthpiece.

Abstract: A method and a device are provided for detecting the respiratory activity of a person and for controlling the time progression of breathing gas pressure, especially in accordance with physical parameters and considering parameters indicating the momentary physiological condition of the breathing person. The device for detecting the respiratory activity of a person has at least one sensor that provides a first signal indicating the breathing gas flow, wherein at least one signal processing device is provided for processing the first signal. The signal processing device is configured in such a way that said device determines a reference-relation on the basis of the first signal detected during a first time interval. On the basis thereof, the device determines a correlation-relation between the reference-relation and the first signal.

Abstract: A system and a method for circuit compliance compensated pressure control in a patient respiratory ventilation system, having a pressure regulated feedback servo control loop, a pressure-regulated volume controller, and a patient volume observer. The patient volume observer is operative to estimate a patient volume, that is, the volume actually delivered to the patient by accounting for volume deviation or loss caused by patient circuit leakage and valve dynamics. Based on the difference between the estimated patient volume and a set tidal volume, the pressure-regulated volume controller is operative to generate and update a circuit compliance pressure compensation factor. The pressure regulated feedback servo control loop is operative to modulate the peak airway pressure based on the circuit compliance pressure compensation factor, so as to achieve the set tidal volume while maintaining a constant inspiratory time and a constant I:E ratio.

Abstract: The present invention relates to a method of delivering combined positive and negative pressure assist ventilation to a patient, wherein a positive pressure is applied to the patient's airways to inflate the patient's lungs, a negative pressure is applied around the patient's ribcage and/or abdomen in order to reduce a load imposed by the ribcage and/or abdomen on the patient's lungs, and application of the positive and negative pressures is synchronized.

Abstract: Described is a system including a sensor and a processing arrangement. The sensor measures data corresponding to a patient's breathing patterns. The processing arrangement analyzes the breathing patterns to determine whether the breathing patterns are indicative of a REM sleep state. In another embodiment, the processing arrangement analyzes the breathing patterns to determine whether the breathing patterns are indicative of one of the following states: (i) a wake state and (ii) a sleep state. In another embodiment, a neural network analyzes the data to determine whether the breathing patterns are indicative of one of the following states: (i) a REM sleep state, (ii) a wake state and (iii) a sleep state. In another embodiment, the processing arrangement analyzes the data to determine whether the breathing pattern is indicative of an arousal.

Abstract: A circuit compliance compensated volume control system in a patient respiratory ventilation system and method, including: a circuit compliance estimator, to provide a relationship between a circuit volume and a differential pressure between a circuit pressure and a positive end-expiratory pressure (PEEP) of the respiratory circuit, a circuit volume estimator, operative to provide an estimated circuit volume based on the relationship between the circuit volume and the differential pressure, a patient volume observer, operative to provide an estimated patient volume by subtracting the estimated circuit volume from a measured machine delivered net volume, and a volume delivery controller, operative to update the machine delivered net volume based on the estimated patient volume and a set tidal volume.

Abstract: A method, system and device are provided for the determination of leaks in a respirator. An inspiraton pressure pinsp is recorded during an inspiration time Tinsp with a measuring device. The inspiration pressure pinsp is varied during consecutive breaths I. Leaks are determined as to leak volumes VLi from the product of pinspi and Tinspi in accordance with the equation VLi=A×pinspiB×Tinspi while the parameters A and B are determined in an analyzing unit by a regression model with pinsp as the regressor.