With Contraceptive, Spermacidal, Or Antifertility Agent Patents (Class 128/832)
-
Patent number: 6165492Abstract: A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e.g., a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e.g., an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity. Compositions and methods for delivering medicaments are also disclosed.Type: GrantFiled: February 18, 1999Date of Patent: December 26, 2000Inventor: Robert S. Neuwirth
-
Patent number: 6125850Abstract: A vaginal device provides physical and chemical barriers to contraception or protection against sexually transmitted diseases, or both. The device includes a towelette having approximately 1 to 10 ml of preventive formulation incorporated therein by absorption. During intercourse, the towelette rests in the upper vagina and effectively functions as both a physical and chemical barrier to contraception. In some embodiments, the towelette may become compressed into a crumpled, disc-like shape, which may enhance its properties as a physical barrier. In other embodiments, the vaginal device includes a flexible ring that is affixed to the towelette to define a dome-shaped towelette portion on one side of the ring and a depending skirt on the other side, with the dome portion being designed to cover the cervix. Means to facilitate insertion and removal of the device are described.Type: GrantFiled: October 13, 1998Date of Patent: October 3, 2000Assignee: Family Health InternationalInventors: David C. Sokal, Laneta J. Dorflinger, J. V. Tapani Luukkainen, Parthena M. Martin
-
Patent number: 5988169Abstract: A vaginal insert and method for delivering an agent to a urogenital tract in a patient, the patient having a vagina, the vagina having anterior and posterior walls. The vaginal insert comprises a main portion and first and second portions operably connected to the main portion. The first and second portions each have an end projecting outward from the main portion, at least one of the projecting ends has means for containing the agent. The projecting ends of the first and second portions are configured to engage the anterior vaginal wall while the main portion engages the posterior vaginal wall, thereby positioning the projecting end of the first portion proximal to one side of the urogenital tract and positioning the projecting end of the second portion proximal to an opposite side of the urogenital tract.Type: GrantFiled: March 29, 1996Date of Patent: November 23, 1999Assignee: Iotek, Inc.Inventors: David W. Anderson, Robert E. Buuck, Arnold W. Thornton, Xiao Kang Zhang
-
Patent number: 5891457Abstract: A method and composition for effecting chemical necrosis of a tissue lining of a mammalian body cavity, particularly a uterine endometrium, by delivering a caustic tissue necrosing composition, e.g., a silver nitrate and dextran paste, to the tissue to be necrosed and allowing the paste to remain in contact with the target tissue for a period of time sufficient to chemically necrose substantially the entirety of the tissue lining, and then contacting the caustic composition with a deactivating agent, e.g., an aqueous sodium chloride solution, thereby rendering the caustic composition non-caustic, and then rinsing the cavity. Compositions and methods for delivering medicaments are also disclosed.Type: GrantFiled: May 12, 1997Date of Patent: April 6, 1999Inventor: Robert S. Neuwirth
-
Patent number: 5819742Abstract: A vaginal device provides physical and chemical barriers to contraception or protection against sexually transmitted diseases, or both. The device includes a towelette having approximately 5 ml of preventive formulation incorporated therein by absorption. During intercourse, the towelette rests in the upper vagina and effectively functions as both a physical and chemical barrier to contraception. In some embodiments, the towelette may become compressed into a crumpled, disc-like shape, which may enhance its properties as a physical barrier. Means to facilitate insertion and removal of the device are described.Type: GrantFiled: October 30, 1997Date of Patent: October 13, 1998Assignee: Family Health InternationalInventors: David C. Sokal, Laneta J. Dorflinger, J.V. Tapani Luukkainen, Parthena M. Martin
-
Patent number: 5816248Abstract: A vaginal insert for delivering an agent to a urogenital tract in a patient. The patient has a vagina, and the vagina has an anterior wall. The vaginal insert comprises a member sized to fit within the vagina. The member has a surface defining a channel configured to engage the anterior vaginal wall and receive tissue proximal to the urethra. The member defines a chamber for retaining a supply of the agent and a plurality of delivery ports. At least some of the delivery ports are located along the channel. The plurality of delivery ports are in fluid communication with the chamber. The vaginal insert also comprises first and second electrodes. The first electrode is operably connected to the member. The first and second electrodes configured to be operably connected to a power source so that an electrical current can pass between the first and second electrodes and through tissue proximal the urethra.Type: GrantFiled: March 29, 1996Date of Patent: October 6, 1998Assignee: Iotek, Inc.Inventors: David W. Anderson, Robert E. Buuck, Arnold W. Thornton, Xiao Kang Zhang
-
Patent number: 5778886Abstract: The invention provides vaginal compositions suitable for preventing conception and transmission of sexually transmitted diseases comprising a spermicidal agent and a peroxygen compound. Preferably, the spermicidal agent is nonoxynol-9. Also preferably, the peroxygen compound is hydrogen peroxide. The spermicidal agent is preferred at about 3% by weight. The peroxygen compound is also preferred at about 3% by weight. In other aspects, the invention provides these compositions at a pH of about 4, preferably about 3 or lower. This pH is favorably maintained with lactic acid. These compositions are preferably encapsulated in the form of a gel.Type: GrantFiled: February 27, 1996Date of Patent: July 14, 1998Inventor: Alfred Shihata
-
Patent number: 5694947Abstract: Intravaginal delivery system including a flexible support means, and a delivery means carried by the support means and containing an active agent wherein the support means comprises a core member substantially in the form of an open ring, and the delivery means comprises at least one polymer body which encircles the core member in a beltwise manner along a portion of a length of the core member.Type: GrantFiled: April 11, 1996Date of Patent: December 9, 1997Assignee: Leiras OyInventors: Matti Lehtinen, Christine Talling
-
Patent number: 5671754Abstract: A method of preventing charged particles from passing through holes in a barrier material which involves surface treating a barrier material with an ionic surfactant to impart a charge to the barrier material. In a preferred embodiment, prophylactics such as condoms and surgical gloves can be treated with an anionic surfactant. Tests have confirmed that such surface treated articles can repel virus particles such as human immunodeficiency (HIV) virus, hepatitis B virus and herpes simplex virus (HSV). Ionic surfactant treated articles include prophylactics such as condoms and diaphragms, gloves, including surgical gloves, surgical masks, respiratory masks and filters, filters, including membrane, and wound dressings, including bandages.Type: GrantFiled: December 9, 1994Date of Patent: September 30, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Robert Schmukler, C. David Lytle
-
Patent number: 5660187Abstract: In the process for preparing an intravaginal application system for the controlled release of substances, a milled sheet of silicone rubber containing the substances is inserted into one mold component of a split mold. The core of the system is arranged on this milled sheet and is covered with a second milled sheet of the same type. The mold is then closed and the milled sheets are vulcanized at a maximum temperature of 120.degree. C.Type: GrantFiled: December 29, 1994Date of Patent: August 26, 1997Assignee: Hoechst AktiengesellshaftInventors: Dietrich Hiller, Theophil Hornykiewytsch
-
Patent number: 5626148Abstract: Device for intrauterine use comprising means (7, 8) for attaching the device to the interior wall of the uterus, as well as a member (1) releasing active agent and connected to the said attachment means. The invention is characterized in that the active agent releasing member (1) is in the form of a closed container enclosing the active agent, the walls of the container being at least partly permeable to the active agent.Type: GrantFiled: February 22, 1994Date of Patent: May 6, 1997Assignee: Leiras OyInventor: Matti Lehtinen
-
Patent number: 5527534Abstract: A product for the administration of an active pharmaceutical agent via the vaginal canal comprising:(a) a sealed, air-tight package, enclosing therein;(b) a sponge impregnated with a liquid containing an effective amount of an active pharmaceutical agent, said liquid being present in an amount greater than that which is blocked within said sponge but less than the saturation value of said sponge such that when said sponge is inserted in the vaginal canal it will release liquid therefrom.Type: GrantFiled: October 21, 1993Date of Patent: June 18, 1996Assignee: Gynetech Laboratories, Ltd.Inventor: John Myhling
-
Patent number: 5494047Abstract: The invention relates to an intrauterine contraceptive device having at least two flexible arms. The contraceptive device is provided with at least two almost horizontal arms having solid tips. The arms, are provided at the front and back with cavities in longitudinal direction. The central point of the contraceptive device is provided with a flexible thread, surrounded by a device acting as contraceptive. The active device may consist of copper rings, which rings are retained by a holding means located below the thread. Next to copper rings a flexible tube provided with openings may be used, into which an active contraceptive drug, for instance a hormone preparation, is inserted. An important advantage of the contraceptive device according to the invention is the absence of the vertical stem of the IUD. The arms and the central point of the contraceptive device are made from a flexible synthetic material which is tolerated by the uterus, preferably from polyethylene.Type: GrantFiled: March 6, 1995Date of Patent: February 27, 1996Inventor: Willem A. A. Van Os
-
Patent number: 5433218Abstract: An improved intra-uterine device which is a deformable element in the form of a plastic fibre (1) releasing a substance which is active into the uterine cavity, the fibre has several strands (3, 3') or loops (2) placed side by side and held together in one assembly zone (4) of reduced dimensions in relation to the length of the said strands or loops, and of an element for attaching it in the uterine cavity, the element being in the form of filament (5) carrying a securing element (6) for hooking to the tissue of the uterus, suitable for insertion with the aid of a needle, and integral with the the fibre. The device is applicable to the field of the intra-uterine contraceptive devices and of the devices for the treatment of the uterus.Type: GrantFiled: December 6, 1993Date of Patent: July 18, 1995Inventor: Dirk Wildemeersch
-
Patent number: 5398698Abstract: In the process for preparing an intravaginal application system for the controlled release of substances, a milled sheet of silicone rubber containing the substances is inserted into one mold component of a split mold. The core of the system is arranged on this milled sheet and is covered with a second milled sheet of the same type. The mold is then closed and the milled sheets are vulcanized at a maximum temperature of 120.degree. C.Type: GrantFiled: November 15, 1989Date of Patent: March 21, 1995Assignee: Hoechst AktiengesellschaftInventors: Dietrich Hiller, Theophil Hornykiewytsch
-
Patent number: 5224493Abstract: An intracervical device for the controlled release of an active agent for the prevention of both specific sexually transmitted diseases and pregnancy. The device consists of an entirely erodible polymer, or a combination of an erodible polymer with a skeletal polymer capable of maintaining therefor mechanical properties over long duration in the body. The active agents can include one or more than one of a large family of insoluble metal salts which have been shown to affect sperm motility and/or viability and are effacious in the prevention of sexually transmitted diseases. These agents are slowly released over a defined period of time ranging from one month to up to 18 months in duration due to erosion of the polymer matrix.Type: GrantFiled: January 30, 1991Date of Patent: July 6, 1993Assignee: Cadco CorporationInventors: Samuel P. Sawan, Harli M. Dollinger, Herbert W. Horne, Jr.
-
Patent number: 5211952Abstract: Contraceptive devices which are effective for extended periods of time are described, in the form of means for releasing an effective amount of a gonadotropin hormone releasing hormone composition and means for releasing an effective amount of an estrogenic hormone over a first period of time, and means for releasing an effective amount of a progestogen for a second period of time, the second period of time being substantially shorter than and running simultaneously with a portion of the first period of time. The gonadotropin hormone releasing hormone composition is selected from gonadotropin hormone releasing hormone, gonadotropin hormone releasing hormone analogues, gonadotropin hormone releasing hormone agonists, gonadotropin hormone releasing hormone antagonists and mixtures thereof. Contraceptive methods employing the devices are also described.Type: GrantFiled: April 12, 1991Date of Patent: May 18, 1993Assignee: University of Southern CaliforniaInventors: Darcy V. Spicer, Malcolm C. Pike
-
Patent number: 5201326Abstract: A rod-shaped medical tampon for releasing an active substance, including (a) a tampon core of compressed fibers selected from the group consisting of cellulose fibers, cotton fibers, and acetate fibers; (b) a tampon cover surrounding said tampon core and being firmly bonded to one another by a glue, the tampon cover comprising a hardened collagen foam or a hardened gelatin foam impregnated with a retardant including a dissolved active substance to be released; and (c) a retrieval string connected to at least one of said tampon core and said tampon cover.Type: GrantFiled: August 28, 1990Date of Patent: April 13, 1993Assignee: VP-SchickedanzInventors: Jorn Kubicki, Norbert Rink
-
Patent number: 5188835Abstract: The invention concerns an intravaginal device comprising a combination of 17.beta.-estradiol and a supporting matrix for treating hypoestrogenic women. The device releases continously 17.beta.-estradiol at a rate of about 0.5 to about 25 .mu.g/24 h. The invention also comprises a method of preparing the device and a method of treating hypoestrogenic women by using the device.Type: GrantFiled: November 12, 1991Date of Patent: February 23, 1993Assignee: Kabi Pharmacia ABInventors: Inga M. Lindskog, Bengt C. H. Sjogren, Sven-Borje Andersson
-
Patent number: 5181527Abstract: A prophylactic device has a first band adapted to be worn around the waist of a human female and a second band connected to the first band and adapted to be worn between the buttocks of a human female such that the anus is covered by the second band. A genitalia shield connects the first band and the second band and covers the perineum of the human female. The genitalia shield portion includes a sheath having an open integral therewith. The sheath is stored in a retracted position in which its length is diminished by a plurality of folded pleats. Placement of a member against the opening of the sheath unfolds the pleats to orient the sheath in an extended position such that the sheath enters the vaginal opening and is oriented within the vagina. Removable tabs attached to the genitalia shield portion and oriented over both sides of the sheath retain lubricant and/or spermicide adjacent to the two sheath sides.Type: GrantFiled: February 11, 1992Date of Patent: January 26, 1993Inventors: James C. Dorsey, Johnnie L. Moore
-
Patent number: 5156164Abstract: A bacteriocidal virocidal sponge containing iodine and a surfactant which can be used as a contraceptive and as therapy for vaginitis. It consists of a polyurethane open cell foam impregnated with a surfactant and iodine. A bactericidal tampon containing an iodophor does not induce toxic shock syndrome.Type: GrantFiled: February 4, 1991Date of Patent: October 20, 1992Inventors: Harry H. LeVeen, Robert F. LeVeen
-
Patent number: 5150718Abstract: The invention relates to an implant of polymeric material which can release a contraceptive agent for a relatively long time when fitted subcutaneously or locally.Type: GrantFiled: February 14, 1992Date of Patent: September 29, 1992Assignee: Akzo N.V.Inventor: Hendrik De Nijs
-
Patent number: 5105827Abstract: This pad, such as a vaginal pad, comprises a body in elastic foam and a finger gripping device for inserting or drawing out the pad; the gripping device is a recess formed in the pad body.Type: GrantFiled: November 13, 1989Date of Patent: April 21, 1992Inventor: Jacques Augros
-
Patent number: 5088505Abstract: The invention relates to an implant of polymeric material which can release a contraceptive agent for a relatively long time when fitted subcutaneously or locally.Type: GrantFiled: June 21, 1990Date of Patent: February 18, 1992Assignee: Akzo N.V.Inventor: Hendrik De Nijs
-
Patent number: 5070889Abstract: A bacteriocidal virocidal sponge containing iodine and/or chlorhexidine and a surfactant which can be used as a contraceptive and virocidal and bacteriocidal sponge positioned within a human body comprising a polyurethane open cell foam impregnated with a surfactant and iodine and/or chlorhexidine. A bactericidal tampon containing an iodophor or chlorhexidine does not induce toxic shock syndrome.Type: GrantFiled: November 15, 1990Date of Patent: December 10, 1991Inventors: Harry H. Leveen, Robert F. Leveen, Eric G. Leveen
-
Patent number: 5044376Abstract: A porous pouch or pad-retaining means in a vaginal diaphragm or a cervical cap, specially designed to securely and removably house a foam pad which pad will dispense Nonoxynol-9 or other spermatostatic/lymphocytostatic chemicals where the chemicals will exert maximal effect during hydrostatic pressure changes occurring during intercourse.Type: GrantFiled: October 2, 1989Date of Patent: September 3, 1991Inventor: Jack W. Shields
-
Patent number: 5025800Abstract: This invention relates to contraceptive devices. More particularly, this invention relates to novel contraceptive devices for males and females which provide immunological barriers to the spread of sexually transmitted diseases along with related methods to prevent the spread of these diseases.Type: GrantFiled: January 26, 1988Date of Patent: June 25, 1991Inventor: Steve T. Zelson
-
Patent number: 5000749Abstract: A bacteriocidal virocidal sponge containing iodine and a surfactant which can be used as a contraceptive and as therapy for vaginitis. It consists of a polyurethane open cell foam impregnated with a surfactant and iodine. A bactericidal tampon containing an iodophor does not induce toxic shock syndrome.Type: GrantFiled: March 2, 1989Date of Patent: March 19, 1991Inventors: Harry H. LeVeen, Eric G. LeVeen, Robert F. LeVeen
-
Patent number: 4959216Abstract: A contraceptive method for living animals (including human beings) can utilize a polyurethane or polyvinylacetate (PVA) disc as an inert carrier for contraceptive preparations, the disc being implanted before intercourse to engage the external os of the cervical canal. Preferred contraceptive preparations include (1) the copper (II) salt of ethylenediamine-tetraacetic acid (EDTACu) and L-L-ascorbic acid; (2) the sialic acid-removing enzyme neuraminidase; and (3) an asialoglycoprotein, such as asialofetuin. Of these preparations, which can be used separately or in any combination, the first two act on the cervical mucus to change it from the open cellular structure found at midcycle of the menstrual period to the closed cellular structure and thus form an impenetrable barrier for spermatozoa. The second and third preparations remove sialic acid from spermatozoa, the presence of which is necessary for successful fertilization.Type: GrantFiled: December 17, 1987Date of Patent: September 25, 1990Assignee: University of QueenslandInventor: Brian Daunter
-
Patent number: 4957119Abstract: The invention relates to an implant of polymeric material which can release a contraceptive agent for a relatively long time when fitted subcutaneously or locally. The implant comprises a core material of ethylene/vinyl acetate copolymer which functions as a matrix for a contraceptive substance, an ethylene/vinyl acetate membrane encasing the core material, and a contact layer at the interface of the core material and membrane which prevents the separation of the core material from the membrane. The implant of the invention is made by a co-extrusion process.Type: GrantFiled: August 5, 1988Date of Patent: September 18, 1990Assignee: Akzo N.V.Inventor: Hendrik de Nijs
-
Patent number: 4922928Abstract: A three layered disposable vaginal device comprised of two resilient compressible polymeric foam layers separated by a non-permeable layer, the outermost layer being designed to include a receptacle. The device is also designed to include a removal tape that will permit the user to easily remove the same after use. The construction is intended for use as a barrier contraceptive with or without spermicide, as a delivery system for medicaments and also as a barrier to the transmission of sexually transmitted diseases.Type: GrantFiled: August 17, 1988Date of Patent: May 8, 1990Inventor: Michael Burnhill
-
Patent number: 4895170Abstract: A disposable cervical cap has a thin, form-assuming pliable dome with an integrally-molded resilient retaining rim. The rim has a bevelled outer shoulder and contains an annular groove on its inner surface. The inner groove and rim define two ascending lips on the inner surface of the rim which prevent dislodgement of the cap from the cervix. The cervial cap includes a set of tabs on its outer surface to assist in positioning and placement of the cap and further includes a loop for removing the cap after use.Type: GrantFiled: July 25, 1988Date of Patent: January 23, 1990Assignee: Page Hanes, Inc.Inventors: Janet M. Tlapek, Margaret D. Tlapek
-
Patent number: 4821741Abstract: A barrier type contraceptive is an umbrella-like device including a flexible, barrier member with a plurality of radially disposed resilient stiffening members associated therewith. The stiffening members bias the barrier member into a generally planar configuration while allowing for the device to be folded into a generally fusiform shape for insertion.Type: GrantFiled: October 5, 1987Date of Patent: April 18, 1989Inventor: Reza S. Mohajer
-
Patent number: 4807610Abstract: An intrauterine device comprises a strip, a rod interconnected with the strip to form a T-shaped element therewith, a coil mounted on the rod, and a thread connected to the rod for dynamic monitoring of the IUD while in the uterine cavity. The coil has at least two layers, of which the first layer is made of an elastic polymer material, serves as a base, and faces directly the rod, while the second layer is made of metal.Type: GrantFiled: September 9, 1987Date of Patent: February 28, 1989Assignee: Nauchno-Proizvodstvennoe Objedinenie "Medinstrument"Inventors: Raisa V. Gainutdinova, Boris A. Jurov, Bentsian M. Mazo, Vera M. Petrova