Abstract: A microfluidic system employs a microchannel and a gravity driven pump comprising horizontally oriented fluid supply reservoirs which supplies fluid to the microchannel at a substantially constant rate. The device is useful for numerous microfluidic applications, for example in the culture and/or treatment of biological systems under constant flow-induced stress, cell-size sorting, motile sperm sorting, or embryo culture.
Type:
Grant
Filed:
July 18, 2002
Date of Patent:
April 27, 2010
Assignee:
The University of Michigan
Inventors:
Shuichi Takayama, Joseph Chang, Dongeun Huh, Xiaoyue Zhu, Brenda Cho, Gary D. Smith
Abstract: The invention relates to a dispersing device wherein the dispersed material has a variable throughput comprising a jet disperser which comprises at least one inlet for the materials to be dispersed, a chamber with a multiciplicity of openings arranged in rows along the chamber wall, which lead into an outlet chamber, and an outlet for the finally dispersed material, wherein the chamber comprises a displaceably mounted piston which, depending on its position within the chamber, partially or completely shuts off a specific number of the openings for the passage of the flow os dispersed material.
Type:
Grant
Filed:
July 4, 2000
Date of Patent:
March 7, 2006
Assignee:
Bayer Aktiengesellschaft
Inventors:
Bernd Klinksiek, Dieter Schleenstein, Wieland Hovestadt, Michael vom Felde