Abstract: The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.
Abstract: The invention relates to a cleaning device particularly for grassed areas. The cleaning device includes a cylindrical brush in contact with a rear roller to clean the roller. The brush can be adjusted to a working height relative to the chassis of the device, along an arcuate path having a center situated on the longitudinal axis of the roller.
Type:
Grant
Filed:
September 5, 2008
Date of Patent:
November 13, 2012
Assignee:
SAS Dairon
Inventors:
Michel Maurice Dairon, Jose Alain Loyer