Abstract: A heat exchanger includes an inlet plenum chamber, an outlet plenum chamber fluidly coupled to the inlet plenum chamber, and a plurality of intermediate plenum chambers disposed downstream from the inlet plenum chamber and upstream from the outlet plenum chamber. The plurality of intermediate plenum chambers includes a first intermediate plenum chamber, at least one tube bundle, and a first bypass valve fluidly coupled to the first intermediate plenum chamber. The first bypass valve is configured to control fluid flow rate from the first intermediate plenum chamber to the outlet plenum chamber.

Abstract: A spray drier system is provided for spray drying a liquid sample such as blood plasma. The spray drier system may include a spray drier device adapted to couple with a spray drier assembly. The assembly may include an enclosure mounted to a frame. The assembly may receive a flow of drying gas which is directed by the enclosure shape towards a spray drying head mounted within the enclosure to the frame. Flows of a liquid sample may be further received by the head, which aerosolizes the liquid sample. Aerosolized liquid sample and drying air may be mixed within a drying chamber of the enclosure to produce dried sample and humid air. The dried sample and humid air may also be separated in a collection chamber of the enclosure, with the humid air exhausted from the enclosure.

Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.

Abstract: The present invention relates to an apparatus which coats a substrate inside the vacuum chamber with the powder transported and entrained on the air from the outside without any extra gas supplier. Namely, the apparatus can coat the powder transported and entrained on the air naturally sucked in from the outside on a substrate through the spray nozzle inside the vacuum chamber as the pressure of the vacuum chamber is controlled and the pressure of the front of the spray nozzle is set under the atmospheric pressure.

Abstract: A process for concentrating wastewater includes combining heated gas and liquid wastewater to form a mixture of heated gas and entrained liquid wastewater, breaking the entrained liquid wastewater into fine entrained liquid wastewater droplets, transferring heat from the heated gas to the entrained liquid wastewater to partially evaporate the entrained liquid wastewater, and removing a portion of the fine entrained liquid wastewater droplets from the mixture to provide a demisted gas.

Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.

Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.

Abstract: The invention relates to a spray drying system and a method for its operation that provides a composition of dry. or essentially solvent free, particles from a solution of an agent. The system comprises a generally vertical tube reactor arranged for counter-current removal of solvent from a process flow fed with aerosol droplets of solution descending from the top said reactor with an ascending gas flow. The reactor includes a perforated process tube for transportation of the process flow from the outlet of an aerosol generating device to a dry particle collecting device. A membrane sleeve essentially surrounds the peripheral area of said process tube and separates the descending process stream from the ascending gas stream. Vaporized solvent is transported from the process stream to the ascending gas stream. A reactor housing is sealingly covering said process tube and membrane sleeve and is provided with means for introducing and/or removing the process fluids.

Abstract: Described herein are devices and techniques for spray drying a fluid to produce a dried powder. Assemblies include a spray drying head attachable to a gas supplier and a liquid sample, such as a standard unit of blood product. The spray drying head can be adapted to provide an aerosolized flow of liquid sample exposed to a drying gas. The assembly also includes a drying chamber adapted to separate the aerosolized flow of liquid sample into a dried powder and humid air. The assembly can be disposable, provided in a sterilized kit and having simplified attachments allowing quick connect and disconnect from the gas and liquid sample. Separation of the powder from the humid air exiting the drying chamber occurs within a filtered collection bag. In some embodiments, one or more of the drying chamber and collection bag are formed form a thin-walled, collapsible material.

Abstract: The invention relates to a spray drying system and a method for its operation that provides a composition of dry. or essentially solvent free, particles from a solution of an agent. The system comprises a generally vertical tube reactor arranged for counter-current removal of solvent from a process flow fed with aerosol droplets of solution descending from the top said reactor with an ascending gas flow. The reactor includes a perforated process tube for transportation of the process flow from the outlet of an aerosol generating device to a dry particle collecting device. A membrane sleeve essentially surrounds the peripheral area of said process tube and separates the descending process stream from the ascending gas stream. Vaporized solvent is transported from the process stream to the ascending gas stream. A reactor housing is sealingly covering said process tube and membrane sleeve and is provided with means for introducing and/or removing the process fluids.

Abstract: A heating system for a spray dryer has a heating element, a heating unit having an open-pore metal foam, and a fluid input and a fluid output. The metal foam is arranged between the fluid input and the fluid output so that fluid which flows in through the fluid input and out through the fluid output is laminarized. A method for simultaneously heating and laminarizing a fluid with the aid of an open-pore metal foam is also disclosed, as is an electrostatic precipitator having a sleeve-shaped electrode connected to a base part of the precipitator. Also disclosed is a device for detaching particles from an inner surface of a sleeve-shaped electrode, a method for detaching particles, and a spray dryer with a heating system as above and/or with an electrostatic precipitator.

Abstract: Process and installation for extracting a monomer from an aqueous broth of a polymer, in which, after the broth has been heated, the broth is subjected to a depressurization in a depressurization chamber and is then introduced into a vertical column, divided into several chambers, on which are superimposed perforated plates, where the broth is flushed with an ascending stream of inert gas.

Abstract: This method achieves spray drying by injection super heated slurry type material counter currently into a duct delivering preheated drying gas. Drying gas velocity is above flooding velocity, and the feed spray is delivered by a variable-flow nozzle valve which maintains constant kinetic energy per unit mass of spray over its flow range. Spray cone angle is also adjusted over the same flow range. Conventional facilities are used for heating drying gas and for collecting dried solids.

Abstract: A relatively simple portable evaporator for quickly evaporating large volumes of water includes a stand with adjustable legs, a frame carrying a tubular housing and a motor rotatably mounted on the stand for rotation around a vertical axis, a fan in the housing driven by the motor, a nozzle rotatably mounted on one end of the housing for directing air from the fan upwardly and outwardly from the housing, and a manifold carrying a plurality of jets for receiving water from a tailings pond or other source and spraying the water into a stream of air exiting the nozzle for expediting evaporation.