Electrode Containing Free Carbon Patents (Class 204/403.15)
  • Patent number: 10928356
    Abstract: A substrate's embedded substrate contact electrode forms a reference voltage point. A gate insulator is spaced outwardly from the substrate and has an exposed outer surface configured for contact with a fluid analyte. A device region is intermediate the substrate and the gate insulator; source and drain regions are adjacent the device region; and a field insulator is spaced outwardly of the drain region, the source region, and the substrate away from the device region. The gate insulator and the field oxide are formed of different materials having different chemical sensitivities to the fluid analyte. The field insulator is coupled to the substrate through the field insulator capacitance. The gate insulator capacitance is much smaller than the field insulator capacitance. The embedded substrate contact electrode can be connected to a separate voltage so that the electrical potential between the substrate and the source region can be controlled.
    Type: Grant
    Filed: October 21, 2016
    Date of Patent: February 23, 2021
    Assignee: International Business Machines Corporation
    Inventors: Paul M. Solomon, Sufi Zafar
  • Patent number: 10175190
    Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: January 8, 2019
    Assignee: INTEL CORPORATION
    Inventors: Noureddine Tayebi, Xing Su, Handong Li
  • Patent number: 8999127
    Abstract: A biological sensor for electrochemical and/or electrical measurement, including at least: a measurement electrode, able to make electrochemical and/or electrical measurements, and including a part of a doped diamond layer of a substrate comprising a stack including a dielectric layer placed between the doped diamond layer and a semiconductor material layer; an electronic circuit for amplifying and/or processing at least one electrical signal intended to be issued by the measurement electrode, electrically connected to the measurement electrode and made in a portion of the semiconductor material layer.
    Type: Grant
    Filed: December 29, 2010
    Date of Patent: April 7, 2015
    Assignee: Commissariat à l'énergie atomique et aux énergies alternatives
    Inventor: Jean-Paul Mazellier
  • Publication number: 20140353154
    Abstract: Nanoelectronic devices for the detection and quantification of biomolecules are provided. In certain embodiments, the devices are configured to detect and measure blood glucose levels. Also provided are methods of fabricating nanoelectronic devices for the detection of biomolecules.
    Type: Application
    Filed: June 16, 2014
    Publication date: December 4, 2014
    Inventors: Kanchan A. Joshi, Ray Radtkey, Christian Valcke
  • Publication number: 20140326600
    Abstract: Carbon nanostructures may be protected and functionalized using a layer-by-layer method whereby functional groups on the carbon nanostructure surface may be further derivatized to incorporate additional functional moieties. Carbon nanostructures functionalized using such a layer-by-layer method may be used to disperse, sort, separate and purify carbon nanostructures and may be used as sensing elements such as voltammetric, amperometric, and potentiometric pH sensors or as biometric sensing elements and electrodes and intracorporeal sensors and electrodes.
    Type: Application
    Filed: September 11, 2012
    Publication date: November 6, 2014
    Applicant: NANOSELECT, INC.
    Inventors: Chunhong Li, David J. Ruggieri
  • Patent number: 8871068
    Abstract: The disclosure concerns a high efficiency electrochemical sensor with high signal yield for determining an analyte in a fluid medium comprising, at least one reference electrode, at least one working electrode having particles of an electrocatalyst in an electrode matrix, and an enzyme that is suitable for determining an analyte is selectively covalently bound to the particles of the electrocatalyst. The disclosure also describes a process for producing the electrochemical sensor and a method for determining an analyte in a fluid medium using the electrochemical sensor. have a high efficiency and thus achieve a high signal yield.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: October 28, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Arnulf Staib, Thomas Meier, Reinhold Mischler, Harald Peschel, Martin Hajnsek
  • Publication number: 20140299468
    Abstract: Apparatus and methods are provided for improving sensitivity, throughput, and efficiency of multi-analyte analytical testing. Specifically, an improved Electrochemiluminescence (ECL) analytical apparatus is provided for analytical chemistry, diagnostics, and environmental applications. The ECL apparatus comprises a 96 or more-well plate, where a microarray of working electrodes is placed in each well for high throughput and multi-analyte testing. The microarray of working electrodes connects with a counter electrode forming a two-electrode electrochemical system. Each well is electrically addressable, thereby controlling ECL reactions in flexible modes. The ECL apparatus further comprises a detector of ECL signals, and the detector employs a CCD-chip assembling matrix. Also provided are methods for high-throughput multi-analyte testing.
    Type: Application
    Filed: June 20, 2014
    Publication date: October 9, 2014
    Inventor: Hongjun Yang
  • Publication number: 20140190824
    Abstract: Embodiments of the invention provide transducers capable of functioning as electronic sensors and redox cycling sensors. Transducers comprise two electrodes separated by a nanogap. Molecular binding regions proximate to and within the nanogap are provided. Methods of fabricating nanogap transducers and arrays of nanogap transducers are also provided. Arrays of individually addressable nanogap transducers can be disposed on integrated circuit chips and operably coupled to the integrated circuit chip.
    Type: Application
    Filed: December 28, 2011
    Publication date: July 10, 2014
    Inventors: Grace M. Credo, Oguz H. Elibol
  • Publication number: 20140124368
    Abstract: An electrochemical biosensor strip is disclosed in the present invention. The electrochemical biosensor strip includes a substrate, an electrode system and a test reagent. The electrode system is disposed on the substrate and is composed of a hydrophilic carbon layer. The test reagent is laid on the substrate and in contact with a portion of the hydrophilic carbon layer. In such a manner, the test reagent can contact the carbon layer without interference, and the dissolved test reagent, the analyte-containing fluid and the product of the interaction of the test reagent and the analyte, while in use, can spread on the hydrophilic carbon layer spontaneously and uniformly, which makes contribution to a better detection performance.
    Type: Application
    Filed: November 6, 2012
    Publication date: May 8, 2014
    Applicant: BIOTEST MEDICAL CORPORATION
    Inventor: Maggie CHU
  • Patent number: 8702961
    Abstract: According to one embodiment of the present invention, an electrochemical sensor (10) for detecting the concentration of analyte in a fluid test sample is disclosed. The sensor (10) includes a counter electrode having a high-resistance portion for use in detecting whether a predetermined amount of sample has been received by the test sensor.
    Type: Grant
    Filed: February 25, 2013
    Date of Patent: April 22, 2014
    Assignee: Bayer HealthCare LLC
    Inventors: Dijia Huang, Steven C. Charlton, Suny J. George, Andrew J. Edelbrock
  • Patent number: 8702923
    Abstract: Disclosed is a method of measuring sample reaction results on a biosensor having a working electrode and other electrodes, including: applying voltage between the working electrode and each of the other electrodes and detecting the amount of current flowing through the working electrode to determine whether or not a sample is injected; applying voltage between the working electrode and one of the other electrodes and re-detecting the amount of current flowing through the working electrode; and acquiring and displaying a concentration value as a sample reaction result corresponding to the amount of detected current.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: April 22, 2014
    Assignee: Infopia Co., Ltd.
    Inventors: Byeong-woo Bae, Sung-dong Lee, Hong-seong Suk, Jin-a Yoo
  • Patent number: 8702932
    Abstract: The present disclosure relates to a sensor including an elongated member including at least a portion that is electrically conductive. The elongated member includes a sensing layer adapted to react with a material desired to be sensed. An insulating layer surrounds the elongated member. The insulating layer defines at least one access opening for allowing the material desired to be sensed to enter an interior region defined between the elongated member and the insulating layer. The insulating layer has an inner transverse cross-sectional profile that is different from an outer transverse cross-sectional profile of the elongated member. The difference in transverse cross-sectional profiles between the elongated member and the insulating layer provides channels at the interior region defined between the insulating layer and the elongated member. The channels extend generally along the length of the elongated member and are sized to allow the material desired to be sensed to move along the length of the sensor.
    Type: Grant
    Filed: August 28, 2008
    Date of Patent: April 22, 2014
    Assignee: Pepex Biomedical, Inc.
    Inventor: James L. Say
  • Publication number: 20140102915
    Abstract: The present disclosure includes an electrochemical proximity assay (ECPA) which leverages two aptamer or antibody-oligonucleotide probes and proximity-dependent DNA hybridization to move a redox active molecule near an electrically conductive base. The ECPA of the present disclosure produces rapid, quantitative results, enabling point-of-care use in the detection of biomarkers of disease.
    Type: Application
    Filed: October 12, 2012
    Publication date: April 17, 2014
    Applicant: AUBURN UNIVERSITY
    Inventors: Jiaming Hu, Tanyu Wang, Christopher J. Easley, Curtis G. Shannon
  • Patent number: 8691075
    Abstract: The blood glucose analysis technique and system described herein address the issue of hematocrit interference when rapidly detecting glucose concentrations. It addresses this issue by using a differential pulse voltammetry technique in which short high, frequency voltage pulses are applied to keep the diffusion layer within the reagent of the working electrode, and the pulses are applied in a limited voltage window (or range) that is below the peak, diffusion-limited current. The readings below the peak are then used to determine glucose concentrations. With this technique, glucose concentrations can be determined relatively fast (e.g., within 5 seconds) and independently of the hematocrit levels of the fluid being analyzed.
    Type: Grant
    Filed: December 30, 2009
    Date of Patent: April 8, 2014
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Georgeta Lica
  • Patent number: 8580104
    Abstract: An electrode for electrochemical analysis is described, the electrode comprising: an insulating surface; a three-dimensional network of carbon nanotubes situated on the insulating surface; and an electrically conducting material in electrical contact with the carbon nanotubes; wherein the carbon nanotubes are oriented substantially parallel to the insulating surface. Also described is a method of manufacturing the electrode, and a method of electrochemically analysing a solution using electrodes of this type, and an associated assay device or kit.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: November 12, 2013
    Assignee: University of Warwick
    Inventors: Patrick Unwin, Julie Macpherson, Ioana Dumitrescu, Jonathan P. Edgeworth
  • Publication number: 20130248380
    Abstract: The present disclosure provides for a biosensor comprising a graphene electrode linked to a biosensing element by a linker, the biosensing element bonded to a flexible substrate. The graphene electrode has a first end and a second end, such that the first end may be a positive terminal and the second end a negative terminal. An electrical voltage may be applied to the positive and negative terminals to measure an electrical current response in proportion to a lactate concentration on the biosensing element. In embodiments, the biosensing element is an enzyme. By way of example, the biosensing element may be LOD.
    Type: Application
    Filed: March 26, 2013
    Publication date: September 26, 2013
    Applicant: Utah State University
    Inventor: Yue Cui
  • Publication number: 20130213823
    Abstract: A diamond electrode and a diamond microelectrode array for biosensors and electroanalytical applications, such as electrochemical impedance spectroscopy (EIS), are disclosed. The electrode comprises a layer of ultra-smooth conductive nanocrystalline diamond (NCD) having a resistivity of >0.05 ?cm and a surface roughness of <20 nm Ra. Preferably, the diamond layer comprises boron or nitrogen-doped ultrananocrystalline diamond (UNCD) having an average grain size <10 nm and a surface roughness <10 nm Ra. It may be patterned to define a microelectrode array with a plurality of individually addressable electrodes, each having a diameter in the range from 100 nm to 100 ?m. The surface of each microelectrode is hydrogen-terminated before bio-functionalization, i.e. modifying with sensing molecules for detection of a specific biological or chemical target and coating with a blocker for reducing non-specific binding.
    Type: Application
    Filed: February 22, 2013
    Publication date: August 22, 2013
    Applicant: Advanced Diamond Technologies, Inc.
    Inventor: Advanced Diamond Technologies, Inc.
  • Patent number: 8512533
    Abstract: A biosensor includes a plurality of electrodes and a receptor. The plurality of electrodes comprises a plurality of carbon nanotubes. The receptor are located between the plurality of electrodes and electrically connected to the plurality of carbon nanotubes of the plurality of electrodes. In addition, the receptor reacts to a measured object to lead current variation which is transmitted by the plurality of electrodes.
    Type: Grant
    Filed: January 18, 2011
    Date of Patent: August 20, 2013
    Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.
    Inventors: Xue-Shen Wang, Qun-Qing Li, Shou-Shan Fan
  • Publication number: 20130206610
    Abstract: Electrochemiluminescent technique and device suitable for cheap analytical and diagnostic applications, with electrodes manufactured from carbon paste and terbium chelates as labeling compounds.
    Type: Application
    Filed: June 10, 2011
    Publication date: August 15, 2013
    Applicant: LABMASTER OY
    Inventors: Sakari Kulmala, Timo Kalevi Korpela, Jarkko Uolevi Eskola, Johanna Suomi, Markus Hakansson, Teppo Tapani Laaksonen
  • Patent number: 8394330
    Abstract: The present invention provides a class of sensors prepared from regions of conducting organic materials and conducting materials that show an increase sensitivity detection limit for amines. The present class of sensors have applications in the detection of spoiled food products and in testing for diseases, such as cholera and lung cancer, which have amines as biomarkers.
    Type: Grant
    Filed: October 1, 1999
    Date of Patent: March 12, 2013
    Assignee: The California Institute of Technology
    Inventors: Nathan S. Lewis, Carol Lewis, Robert Grubbs, Gregory Allen Sotzing
  • Patent number: 8327460
    Abstract: The present invention allows simple and sensitive detection of microimpurities, microdefects, and corrosion starting points which may be present in a material. A probe microscope has a function to sense ions diffused from a specimen in a liquid. A probe is caused to scan over a predetermined range on a specimen. Then, the probe is fixed to a particular position in a liquid so as to set the distance between the specimen and the probe to a given value at which the microstructure of the specimen surface cannot be observed. Thereafter, one of the current between the probe and a counter electrode and the potential between the probe and a reference electrode is controlled, and the other of the current and potential which varies in accordance with the control is measured. Thus, ions diffused from the specimen are sensed.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: December 4, 2012
    Assignee: Hitachi, Ltd.
    Inventors: Kyoko Honbo, Katsumi Mabuchi, Motoko Harada
  • Publication number: 20120255860
    Abstract: Certain embodiments of the present application describe a carbon-based electrode with graphene platelets. The addition of graphene platelets is intended to improve properties of the electrode. These properties include, but are not limited to, physical, electrical, and biochemical properties of the electrode. Enhanced reproducibility of these properties can also result from the addition of the graphene platelets.
    Type: Application
    Filed: December 21, 2010
    Publication date: October 11, 2012
    Applicant: PROXIM DIAGNOSTICS
    Inventors: Mikhail Briman, Vikram Joshi
  • Publication number: 20120181173
    Abstract: The invention relates to an electrochemical sensor for the detection of analytes in liquid media which comprises 4 layers, wherein the first layer (1) comprises a carbonaceous material deposited on a substrate, said layer forming the system of electrodes of the electrochemical sensor, formed at least by a pseudo-reference electrode, a working electrode and a counter electrode; and the fourth layer (4) comprises polythiophene deposited only on the lower end of the working electrode selected from (d1), which comprises a layer comprising a polythiophene deposited on the lower end of the working electrode and a layer comprising a non-conductive polymer gel deposited on said layer of polythiophene; (d2), which is a layer of conductive polymer gel comprising a non-conductive polymer gel and a polythiophene; and (d3), which comprises a layer comprising a polythiophene deposited on the lower end of the working electrode and a layer comprising functionalized magnetic nanoparticles deposited on said layer of polythioph
    Type: Application
    Filed: July 23, 2010
    Publication date: July 19, 2012
    Applicant: FUNDACION CIDETEC
    Inventors: Estibaliz Ochoteco Vaquero, Elena Jubete Diez, José Adolfo Pomposo Alonso, Hans-Jurgen Grande Telleria, Oscar A. Loaiza, German Cabañero, Georges Istamboulie, Thierry Noguer, Jean Louis Marty
  • Publication number: 20110297556
    Abstract: An electrode for electrochemical analysis is described, the electrode comprising: an insulating surface; a three-dimensional network of carbon nanotubes situated on the insulating surface; and an electrically conducting material in electrical contact with the carbon nanotubes; wherein the carbon nanotubes are oriented substantially parallel to the insulating surface. Also described is a method of manufacturing the electrode, and a method of electrochemically analysing a solution using electrodes of this type, and an associated assay device or kit.
    Type: Application
    Filed: December 11, 2009
    Publication date: December 8, 2011
    Inventors: Patrick Unwin, Julie Macpherson, Ioana Dumitrescu, Jonathan P. Edgeworth
  • Publication number: 20110180405
    Abstract: In some aspects, an analyte sensor is provided for detecting an analyte concentration level in a bio-fluid sample. The analyte sensor may include one or more conductors received in a hollow portion of a hollow member. The first conductor may be made, at least in part, of a semiconductor material and an active region may be provided in contact with at least the first conductor. The analyte sensor may, in one aspect, include a lancet and an integrated sensor. Manufacturing methods and apparatus and systems utilizing the analyte sensors are provided, as are numerous other aspects.
    Type: Application
    Filed: September 18, 2009
    Publication date: July 28, 2011
    Applicant: Bayer HealthCare LLC
    Inventors: Swetha Chinnayelka, Jiangfeng Fei, Narasinha Parasnis, Serban Peteu, Yuan Wang
  • Publication number: 20110165458
    Abstract: Electrically conductive fibers made of carbon nanotubes that are assembled and covered by at least one deposit that includes a biopolymer, the manufacturing of these electrodes and the use of these electrodes in bioelectrochemical systems such as, for example, enzymatic or immunological biosensors, DNA, RNA, and biobatteries.
    Type: Application
    Filed: June 8, 2009
    Publication date: July 7, 2011
    Applicant: Centre National De La Recherche Scientifique (CNRS)
    Inventors: Nicolas Mano, Philippe Poulin
  • Publication number: 20110162962
    Abstract: A biological sensor for electrochemical and/or electrical measurement, including at least: a measurement electrode, able to make electrochemical and/or electrical measurements, and including a part of a doped diamond layer of a substrate comprising a stack including a dielectric layer placed between the doped diamond layer and a semiconductor material layer; an electronic circuit for amplifying and/or processing at least one electrical signal intended to be issued by the measurement electrode, electrically connected to the measurement electrode and made in a portion of the semiconductor material layer.
    Type: Application
    Filed: December 29, 2010
    Publication date: July 7, 2011
    Applicant: Comm. a l'ener. atom. et aux energies alter.
    Inventor: Jean-Paul MAZELLIER
  • Patent number: 7955856
    Abstract: An auto-calibration system for diagnostic test strips is described for presenting data individually carried on each test strip readable by a diagnostic meter. The carried data may include an embedded code relating to data particular to that individual strip. The data is presented so as to be read by a meter associated with the diagnostic test strip in order to avoid manually inputting the information.
    Type: Grant
    Filed: November 9, 2006
    Date of Patent: June 7, 2011
    Assignee: Nipro Diagnostics, Inc.
    Inventors: Gary T. Neel, Brent E. Modzelewski, Allan Javier Caban, Adam Mark Will, Carlos Oti, Natasha Popovich, Stephen Davies
  • Publication number: 20100294672
    Abstract: In a method and apparatus for determining information concerning the presence of ingredients with oxygen demand in a liquid sample, especially for determining the chemical oxygen demand of a liquid sample, especially a water, or wastewater, sample, by means of electrochemical oxidation of ingredients of the liquid sample, oxidation of ingredients of the liquid sample occurs on a boron doped, diamond electrode.
    Type: Application
    Filed: May 25, 2010
    Publication date: November 25, 2010
    Applicant: Endress + Hauser Conducta Gesellschaft Fur Mess- und Regeltechnik mbH + Co. KG
    Inventors: Achim Gahr, Rudolf Bauer
  • Patent number: 7731867
    Abstract: The invention is directed to conductive polymer compositions, catalytic ink compositions (e.g., for use in screen-printing), electrodes produced by deposition of an ink composition, as well as methods of making, and methods of using such compositions and electrodes. An exemplary ink material comprises a metal catalyst (e.g., platinum black and/or platinum-on-carbon), graphite as a conducting material, a polymer binding material, and an organic solvent. In one aspect, the polymer binding material comprises a polymer binder blend comprising first and second polymers, wherein the first polymer has a glass transition temperature higher than the second polymer. In a second aspect, the polymer binding material comprises a hydrophilic acrylic polymer, copolymer, or terpolymer. The conductive polymer compositions of the present invention may be used, for example, to make electrochemical sensors. Such sensors may be used, for example, in a variety of devices to monitor analyte amount or concentrations in subjects.
    Type: Grant
    Filed: January 23, 2007
    Date of Patent: June 8, 2010
    Assignee: Animas Technologies, LLC
    Inventors: Huawen Li, Michael J. Tierney
  • Publication number: 20100133102
    Abstract: The present invention relates to sensors and sensor systems that utilize combinational artificial receptors. Embodiments of the present invention employ combinational artificial receptors in electromagnetic (e.g. optical) and electrochemical sensors.
    Type: Application
    Filed: October 30, 2008
    Publication date: June 3, 2010
    Applicant: RECEPTORS, LLC
    Inventor: Robert E. Carlson
  • Publication number: 20100089774
    Abstract: A non-enzymatic electrochemical method of simultaneous measurement of hemoglobin (Hb) and percentage of glycated hemoglobin (% HbA1c) in a blood sample is disclosed. The method includes determining the total amount of hemoglobin in a sample by electrochemically measuring the voltammetric current due to iron (II) and iron (III) redox portions in hemoglobin and determining the percentage of glycated hemoglobin (HbA1c) by potentiometry. Also disclosed is a novel screen-printed electrode (SPE) strip modified for potentiometric measurement of HbA1c.
    Type: Application
    Filed: February 6, 2009
    Publication date: April 15, 2010
    Inventors: Venkat Manohar, George Varghese, Yegnaraman Venkatraman, Phani Lakshminarasimha Kanala, Mathiyarasu Jayaraman
  • Publication number: 20100044225
    Abstract: A nano-structure is provided. In some embodiments, the nano-structure includes a carbon nanotube with a carbon nanotube body. The carbon nanotube body has at least one cap at one end of the nanotube body. Also provided are methods of making the nano-structures described herein.
    Type: Application
    Filed: August 25, 2008
    Publication date: February 25, 2010
    Inventors: Yong Hyup Kim, Tae June Kang
  • Publication number: 20090301900
    Abstract: The present claimed invention is to provide a method for measuring a protein that enables to detect the protein with high accuracy and high sensitivity through an electrochemical method at a high speed with a simple operation using a simple device. With the method, a working electrode 5 and a counter electrode 4 are made to contact with a sample solution 1 containing the protein as being an object to be measured, and a voltage is impressed between the working electrode 5 and the counter electrode 4 so that a current value at the voltage can be measured and the protein can be electrochemically analyzed.
    Type: Application
    Filed: March 29, 2007
    Publication date: December 10, 2009
    Inventors: Yasuaki Einaga, Tribidasari Anggraningrum Ivandini, Masanobu Chiku, Mikito Yamanuki, Koichi Matsumoto
  • Publication number: 20090288962
    Abstract: A mercury-free, electrochemical sensor is described that includes a self-assembled monolayer on a mesoporous support (SAMMS) composite and a fluoropolymer component that is deposited on a measurement surface. The SAMMS component provides outstanding metal preconcentration. The fluoropolymer component acts as an antifouling binder. The sensor can detect various metals at a low detection level in the presence of fouling agents and without sample pretreatment. The sensor is also able to detect mixtures of metals simultaneously with excellent single and inter-electrode reproducibility. Service lifetimes are excellent.
    Type: Application
    Filed: April 21, 2009
    Publication date: November 26, 2009
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Wassana Yantasee, Glen E. Fryxell, Raymond S. Addleman, Yuehe Lin, Charles Timchalk
  • Publication number: 20090283424
    Abstract: A sensor electrode for the detection of nucleotides in a biological sample is described. The sensitivity of the electrode is enhanced by the nanostructured sensor architecture that increases the available surface area of the electrode. The electrode detects nucleotides using standard electrochemical methods.
    Type: Application
    Filed: March 9, 2009
    Publication date: November 19, 2009
    Inventors: Charles A. Carson, Hao Li, Qingsong Yu
  • Publication number: 20090218239
    Abstract: Disclosed herein is an electrochemical sensor for detecting an analyte. The sensor comprises an electrode, a redox active species that is electrochemically accessible to the electrode, and a binding moiety capable of associating with the analyte, wherein association of the binding moiety with the analyte affects the electrochemistry of the redox active species. Also disclosed herein is a method for detecting the presence of an analyte in a sample.
    Type: Application
    Filed: March 16, 2007
    Publication date: September 3, 2009
    Applicant: NEWSOUTH INNOVATIONS PTY LIMITED
    Inventors: John Justin Gooding, Guozhen Liu
  • Publication number: 20090090623
    Abstract: The invention discloses a biosensor includes a strip having an integrated heating element and an electrode with metallized graphite including metal in the range of 0.1-5% in weight; graphite in the range of below 55% in weight; and polymer. The biosensor further includes an electric measuring device having a slot enabling the strip to insert therein.
    Type: Application
    Filed: May 15, 2008
    Publication date: April 9, 2009
    Applicant: DELTA ELECTRONICS, INC.
    Inventors: Min-Chieh Chuang, Yun-Chu Ho, Tai-Kang Shing, Chung-Chiun Liu, Jie Shen
  • Publication number: 20090065357
    Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.
    Type: Application
    Filed: October 2, 2008
    Publication date: March 12, 2009
    Applicant: MESO SCALE TECHNOLOGIES, LLC
    Inventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
  • Publication number: 20090065369
    Abstract: Embodiments of the present invention provide a method for detecting a composition comprising (a) providing a first composition which reacts with an oxidase to generate a second composition; (b) providing nitrogen-doped nanocarbons; and (c) detecting the first composition with the nanocarbons. Devices and systems containing such nitrogen-doped nanocarbons are also provided.
    Type: Application
    Filed: September 10, 2008
    Publication date: March 12, 2009
    Applicant: The Board of Regents, The University of Texas System
    Inventors: Keith J. Stevenson, Jennifer L. Lyon
  • Publication number: 20080283397
    Abstract: Electrochemical transducer arrays are already known from the prior art. According to the invention, the transducer array is provided with at least one flexible, planar metal substrate on which at least one flexible insulator having a firm connection between the metal surface and the insulator surface is disposed. The metal substrate and the insulator disposed thereon are structured in such a manner as to give metal areas which are electrically insulated the one from the other and which serve as sensor areas. The metal substrate used is self-contained so that the structured metal areas can be contacted from the lower side.
    Type: Application
    Filed: January 26, 2005
    Publication date: November 20, 2008
    Inventors: Heike Barlag, Walter Gumbrecht, Manfred Stanzel
  • Publication number: 20080251394
    Abstract: The method according to the invention consists of generating an electrochemical signature of the analyzed substance(s), obtained by carrying out a numerical pseudo-titration and to express the result of the measurements in antioxidant power units. It involves the processing of a current-potential response of the oxidation of the analyzed substance(s) by a predefined mathematical dimensionless function representing a virtual and ideal oxidizing agent. The method is useful for the identification and/or detection and/or titration of antioxidant substances in the tested material, including directly on wet biological tissues.
    Type: Application
    Filed: March 11, 2005
    Publication date: October 16, 2008
    Applicant: Edel Therapeutics S.A.
    Inventors: Gregoire Lagger, Philippe Tacchini, Hubert H. Girault
  • Publication number: 20080105544
    Abstract: The present invention provides an electrode for electrochemical measurement including a carbon nanotube, a catalyst causing a specific chemical reaction, and an insulator in which the carbon nanotube and the catalyst are embedded, wherein a part of the catalyst is exposed at the surface of the insulator and a part of the carbon nanotube is exposed at the surface of the insulator to form an electoconductive portion, or wherein a part of the catalyst is exposed at the surface of the insulator, and a part of the carbon nanotube is electrically connected to the exposed catalyst to form an electoconductive portion.
    Type: Application
    Filed: June 9, 2004
    Publication date: May 8, 2008
    Applicant: FUJI XEROX CO., LTD.
    Inventors: Taishi Shigematsu, Miho Watanabe, Chikara Manabe, Hiroyuki Watanabe
  • Patent number: 7189341
    Abstract: The invention is directed to conductive polymer compositions, catalytic ink compositions (e.g., for use in screen-printing), electrodes produced by deposition of an ink composition, as well as methods of making, and methods of using such compositions and electrodes. An exemplary ink material comprises a metal catalyst (e.g., platinum black and/or platinum-on-carbon), graphite as a conducting material, a polymer binding material, and an organic solvent. In one aspect, the polymer binding material comprises a polymer binder blend comprising first and second polymers, wherein the first polymer has a glass transition temperature higher than the second polymer. In a second aspect, the polymer binding material comprises a hydrophilic acrylic polymer, copolymer, or terpolymer. The conductive polymer compositions of the present invention may be used, for example, to make electrochemical sensors. Such sensors may be used, for example, in a variety of devices to monitor analyte amount or concentrations in subjects.
    Type: Grant
    Filed: October 24, 2003
    Date of Patent: March 13, 2007
    Assignee: Animas Technologies, LLC
    Inventors: Huawen Li, Michael J. Tierney
  • Patent number: 6827899
    Abstract: A test device for testing of analyte concentration in a fluid comprises: a housing (2) having an opening and containing a stack of sensors (16); a transport member (4) rotatably mounted in the opening of the housing, having an axis of rotation which spans the opening; a spring (24) which urges the stack against the transport member; and sealing means (20, 34) for making a moisture tight seal between the transport member and the sensors when the transport member is in a specified rotational position. An outer surface of the transport member has a recessed region (12) which is adapted to receive a single sensor from the stack. Rotation of the transport member with a sensor in the recessed region transports the sensor to a location where it can be connected to a meter (6, 8) and receive a drop of fluid to be tested.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: December 7, 2004
    Assignee: Hypoguard Limited
    Inventors: Graeme Antony Maisey, James Aitken, Andrew James Woodhead, Stuart Richard May, Michael Pearson, Murdo M. Black, James George Elcoaté Smith
  • Patent number: 6808619
    Abstract: In an electrode system, particularly for electrochemical sensors, which comprises a working electrode, a counterelectrode and an electrolyte, the counterelectrode is constituted by a material containing an elementary carbon, whereby the long-term stability of the electrode system is considerably increased (FIG. 2).
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: October 26, 2004
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Helmut Offenbacher
  • Publication number: 20040178066
    Abstract: A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1.
    Type: Application
    Filed: March 25, 2004
    Publication date: September 16, 2004
    Inventors: Shoji Miyazaki, Hiroyuki Tokunaga, Masaki Fujiwara, Eriko Yamanishi, Yoshinobu Tokuno
  • Publication number: 20040163954
    Abstract: A thick film electrochemical microsensor device for measuring or regulating chlorine and bromine in water, comprising a substrate to which is applied an optimum arrangement of at least two electrodes. The device is especially useful for measuring or regulating chlorine and bromine levels in swimming pool or spa water. A method of measuring or regulating ions of at least one of chlorine and bromine in water is also described, which comprises contacting the water with the microsensor of the present invention; measuring the current output of the microsensor; determining the level of at least one of chlorine and bromine indicated by the current output; and generating a signal.
    Type: Application
    Filed: February 23, 2004
    Publication date: August 26, 2004
    Inventors: Bonnie Gurry, Meijun Shao, Laurie Dudik, Chung-Chiun Liu
  • Publication number: 20040026243
    Abstract: Sensors formed from a substrate, an electrode layer and at least a first reagent layer are manufactured by transporting a continuous web of the substrate past at least two print stations, and printing the electrode layer and the first reagent layer on the substrate. One of the print stations prints the electrode layer on the continuous web of substrate, and the other of the print stations prints the first reagent layer on the continuous web of substrate as it is transported past the print stations. Additional print stations may be included for the printing of insulation layers, glue prints and the like. The order of printing will depend on the structure desired for the sensor, although the electrode layer(s) will frequently be deposited before the reagent layer(s).
    Type: Application
    Filed: August 7, 2003
    Publication date: February 12, 2004
    Inventors: Oliver William Hardwicke Davies, Jerome Francis McAleer, Robert Malcolm Yeudall
  • Patent number: 6660141
    Abstract: The present invention relates to an electrochemical sensor for a liquid sample. The sensor comprises a substrate (1) along which a liquid may travel by capillary action, said substrate being associated with an electrochemical detection arrangement (3) and a power source therefor, wherein the power source comprises at least one pair of electrodes (7, 8) of dissimilar material provided on the substrate and arranged such that liquid travel between the electrodes causes a current to be generated for operating the electrochemical detection arrangement.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: December 9, 2003
    Assignee: Moorlodge Ventures Limited
    Inventors: Stephen Minter, Timothy Minter