With Measuring, Testing, Or Sensing Patents (Class 204/556)
  • Patent number: 10093969
    Abstract: In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of at least one agent that generates a ligatable terminal 5? phosphate group by removing an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, an aprataxin enzyme can catalyze removal of an adenylate group from a terminal 5? phosphate of a nucleic acid. In some embodiments, methods for ligating nucleic acid ends comprise: conducting a nucleic acid ligation reaction in the presence of an aprataxin enzyme under conditions suitable for ligating nucleic acid ends.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: October 9, 2018
    Assignee: Life Technologies Corporation
    Inventors: Stephen Hendricks, David King, Lei Xi, Marian Peris
  • Patent number: 10077472
    Abstract: A sensor device includes a sensor array and a flow cell in fluid communication with the sensor array. Bias circuitry apply bias arrangements to the sensor array to produce sensor data. Peripheral circuitry coupled to the bias circuitry produces streams of data from the sensor array, the peripheral circuitry having an active mode and an idle mode. Logic to switch the peripheral circuitry between the active mode and the idle mode to control power consumption is provided. A temperature sensor may be included, and the logic can operate with feedback to switch between the active mode and the idle mode to maintain the temperature within an operating range.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: September 18, 2018
    Assignee: LIFE TECHNOLOGIES CORPORATION
    Inventors: Keith G. Fife, Jungwook Yang
  • Patent number: 9671364
    Abstract: An array of micro-chambers (220) with individual ion sensitive field effect transistors (ISFETs) (300) disposed therein for monitoring single cell activity in the microarray to determine the presence or absence of microorganisms in a sample (390). In addition to the presence or absence of a single cell, certain further embodiments contemplate monitoring cell behavior. Cell behavior includes the entire range of cell activity as well as cell response to changes in environmental conditions of changes in response due to the addition of sample constituents.
    Type: Grant
    Filed: December 19, 2012
    Date of Patent: June 6, 2017
    Assignee: Becton, Dickinson and Company
    Inventors: Song Shi, James G. Nadeau, Michael A. Brasch
  • Patent number: 9540256
    Abstract: The present disclosure provides a liquid treatment device, a liquid treatment method, and a plasma treatment liquid each capable of efficiently generating plasma and treating a liquid in a short time period. A liquid treatment device according to the present disclosure includes a first electrode, a second electrode disposed in a liquid to be treated, an insulator disposed around the first electrode with a space between the first electrode and the insulator, the insulator has an opening portion in a position in contact with the liquid to be treated, a power supply that applies voltage between the first electrode and the second electrode, and a supply device supplying a liquid to the space before the power source applies the voltage.
    Type: Grant
    Filed: March 18, 2015
    Date of Patent: January 10, 2017
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Masaki Fujikane, Mari Onodera, Hironori Kumagai, Shin-ichi Imai
  • Patent number: 9228232
    Abstract: There is a need for improved methods for determining the diagnosis and prognosis of patients with conditions, including autoimmune disease and cancer. Provided herein are methods for using DNA sequencing to identify personalized biomarkers in patients with autoimmune disease and other conditions. Identified biomarkers can be used to determine the disease state for a subject with an autoimmune disease or other condition.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: January 5, 2016
    Assignee: Sequenta, LLC.
    Inventors: Malek Faham, Thomas Willis
  • Patent number: 9000783
    Abstract: A device, apparatus and method for trapping metal ions and detecting metal ion contamination in a solution provide a semiconductor device formed on a semiconductor substrate and including an N-well formed over a P-type substrate and at least a contact portion of the N-well in electrical contact with the solution. When the semiconductor device is optically illuminated, a P/N junction is formed as a result of photovoltaic phenomena. Metal ions from the solution migrate to the contact area due to the voltage created at the P/N junction. The semiconductor device includes a conductive structure with conductive features separated by a gap and therefore in an initially electrically open state. When the ions migrate to the contact area, they precipitate, at least partially bridging the gap and creating conductance through the conductive structure. The conductance may be measured to determine the amount of metal ion contamination.
    Type: Grant
    Filed: August 2, 2010
    Date of Patent: April 7, 2015
    Assignee: Wafertech, LLC
    Inventors: Re-Long Chiu, Jason Higgins
  • Patent number: 8888997
    Abstract: A centralized supply system for electrolyzed oxidizing water comprises a water softener (1), several parallel electrolyzed oxidizing water generators (2) connected, liquid storage tanks (3, 4) and delivery pumps (5, 6). A central controller (10) implements independent control over the several parallel electrolyzed oxidizing water generators (2). Liquid level sensors (9) are mounted in the liquid storage tanks (3, 4) and are connected with the central controller (10) via data collection cables (12). With the detection, determination and calculation for the liquid level signal in the liquid storage tanks (3, 4) using the central controller (10), the volume magnitude and the rate of change of the volume for the liquid in the liquid storage tanks (3, 4) can be exactly obtained in time. The electrolyzed oxidizing water generators (2) are effectively controlled based on above data. An intelligent control method for the system is also provided.
    Type: Grant
    Filed: September 22, 2011
    Date of Patent: November 18, 2014
    Assignee: Global Resource Envi-Tech Co., Ltd.
    Inventors: Dunjie Zhang, Xiangbing Kong
  • Patent number: 8864967
    Abstract: A device for displacing a small volume of liquid under the effect of an electric control, including a first substrate with a hydrophobic surface provided with a first electrical conductor, a second electrical conductor positioned facing the first conductor, and a third conductor, forming with the second conductor, a mechanism for analyzing or heating a volume of liquid.
    Type: Grant
    Filed: June 30, 2005
    Date of Patent: October 21, 2014
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Gilles Marchand, Yves Fouillet, Philippe Clementz
  • Patent number: 8828210
    Abstract: This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).
    Type: Grant
    Filed: October 16, 2008
    Date of Patent: September 9, 2014
    Assignee: Cambridge Enterprise Limited
    Inventors: Chris Abell, Wilhelm T. S. Huck, Daniel Bratton, Graeme Whyte, Luis M. Fidalgo
  • Patent number: 8709222
    Abstract: In an electrolytic apparatus for removing contaminants from water, a set (110) of spaced apart conductive electrodes (40) in a reaction chamber (54, 112, 114), is arranged in oppositely charged groups of first and second interleaved electrodes with flow paths between them. Non-conductive turbulence inducers (158, 168) on the faces of electrodes (40) are applied to water in the flow paths. One variety is modular elements (158) with stepped increases in width to present a narrow leading edge in the direction of flow. Another variety is a continuous set of wave guides (168) bordering the flow path. Electrodes (40) are selectively powered in patterns creating turbulence, with effective patterns including a first and last electrode powering pattern and a mini-cell electrode powering pattern.
    Type: Grant
    Filed: June 16, 2011
    Date of Patent: April 29, 2014
    Assignee: Latitutde Clean Tech Group, Inc.
    Inventors: F. William Gilmore, Russell Richard Renk
  • Patent number: 8709258
    Abstract: Described herein are systems, methods, and apparatuses for aggregating microorganism in an aqueous suspension. In particular, are systems, methods, and apparatuses that apply an electrical field to an aqueous suspension comprising microorganisms as the aqueous suspension follows a flow path to cause aggregation of the microorganisms. The electrical field may comprise different types of pulses. In some embodiments, the flow path for the aqueous suspension may vary.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: April 29, 2014
    Assignee: Heliae Development, LLC
    Inventors: Justin S. Kniep, Aniket Kale
  • Patent number: 8658043
    Abstract: A water treatment system provides treated water to a point of use by removing at least a portion of any hardness-causing species contained in water from a water source, such as municipal water, well water, brackish water and water containing foulants. The water treatment system typically receives water from the water source or a point of entry and purifies the water containing at least some undesirable species before delivering the treated water to a point of use. The water treatment system has a pressurized reservoir system in line with an electrochemical device such as an electrodeionization device. The water treatment system can have a controller for adjusting or regulating at least one operating parameter of the treatment system or a component of the water treatment system. The electrochemical device can be operated at a low current and low flow rate to minimize water splitting or polarization, which minimizes scale formation.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: February 25, 2014
    Assignee: Siemens Water Technologies LLC
    Inventors: Frederick Wilkins, Evgeniya Freydina, Aytac Sezgi, Reshma Madhusudan, Anil D. Jha
  • Publication number: 20140014516
    Abstract: The plasma-generating apparatus includes a treatment vessel 509 containing to-be-treated water 510, a first electrode 504 and a second electrode 502 within the treatment vessel, a bubble-generating part which generate a bubble 506 such that a surface where conductor of the first electrode 504 is exposed to the to-be-treated water is positioned within the bubble 506, a gas-supplying apparatus 505 which supplies gas to the bubble-generating part, a pulsed power supply 501 connected to the first and the second electrodes 502 and 504, a control apparatus 520 which controls one or both of the gas-supplying apparatus and the power supply such that the voltage is applied between the first and the second electrodes 502 and 504 when at least surface where the conductor of the first electrode 504 is exposed is positioned within the bubble.
    Type: Application
    Filed: September 20, 2013
    Publication date: January 16, 2014
    Applicant: PANASONIC CORPORATION
    Inventors: Hironori KUMAGAI, Shin-ichi IMAI
  • Patent number: 8597484
    Abstract: A system and method for quantifying opaque inhomogeneities within a fluid sample. The system uses an optical lens system to focus a light beam onto a stage where the sample is introduced. The light beam is directed onto the sample in a pattern such that the intensity of transmitted light is measured as a function of path length. A photo detector measures the transmitted light through the sample. Fluctuations in transmitted light intensity are then correlated with detection of opaque inclusions in the sample. The system also includes an automated program which utilizes these optical concentration measurements to determine the fouling potential of visbroken tars, and regulates the introduction of chemical inhibitors into a visbreaker unit to improve the yield of light streams and/or economic value of product.
    Type: Grant
    Filed: November 10, 2009
    Date of Patent: December 3, 2013
    Assignee: General Electric Company
    Inventors: Andre Vanhove, Tiffany N. Morris, Alan E. Goliaszewski, Brian W. Lasiuk, Donato Vinciguerra
  • Patent number: 8524506
    Abstract: Methods for sampling a liquid flow are provided. The method includes supplying a continuous liquid flow from a continuous flow fluid input source to a surface along a first flow path. The method additionally includes sampling the continuous liquid flow by performing an electric field-based technique to split off a sample droplet from a portion of the liquid flow, whereby the sample droplet is distinct from the liquid flow and controllable independently of the liquid flow, wherein the electric field-based technique is performed by providing a set of electrodes on the surface and selectively biasing the set of electrodes, whereby the sample droplet is formed on one of the set of electrodes.
    Type: Grant
    Filed: November 7, 2007
    Date of Patent: September 3, 2013
    Assignee: Duke University
    Inventors: Vamsee K. Pamula, Michael G. Pollack, Richard B. Fair
  • Patent number: 8313629
    Abstract: Water treatment, reconditioning, and reclamation systems and methods are described. The systems utilize two treatment vectors. The first treatment vector is created by flowing electrical current through a first conductive rod. The second treatment vector is created by delivering a magnetic pulse by way of a second conductive rod. Water to be treated is exposed to the two vectors simultaneously, which is accomplished by creating relative motion between the conductive rods and the water, either by moving the conductive rods or by moving the water. The electric current of the first treatment vector and the voltage and frequency of the magnetic pulse of the second treatment vector may be reduced as the treatment process proceeds. During treatment, total dissolved solids (TDS) rise and congeal at the top of the water. The congealed TDS are removed from the water. An additional filtering process may be applied.
    Type: Grant
    Filed: August 27, 2008
    Date of Patent: November 20, 2012
    Assignee: Sweetwater Reclamation, LLC
    Inventor: Andre Kostrzewa
  • Patent number: 8196218
    Abstract: An exemplary, highly integrated, SPM-based system for measuring the conductivity and/or force of substance under programmable engaging/stretching processes is described. A sample bias is applied across two electrodes. A substance to be measured is sandwiched between them. A first electrode is first brought relative to a second electrode (engaging) in programmable pathways that can be described as stretching distance versus time curves. The process of engaging the electrodes continues until a certain current reached, a certain force reached and whichever case happens first. The electrodes are then separated (stretching) in programmable pathways that can be described as stretching distance versus time curves. A periodic modulation can be applied to the engaging/stretching process to realize different stretch pathways. The sample bias across the electrodes is kept constant or swept in a programmable shape over time, described as a voltage-versus time curve.
    Type: Grant
    Filed: March 30, 2009
    Date of Patent: June 5, 2012
    Assignee: University of Georgia Research Foundation, Inc.
    Inventors: Bingqian Xu, Fan Chen
  • Publication number: 20120091004
    Abstract: This invention relates to microfluidic systems and more particularly to methods and apparatus for accessing the contents of micro droplets (114) in an emulsion stream. A method of accessing the contents of a droplet (114) of an emulsion in a microfluidic system, the method comprising: flowing the emulsion alongside a continuous, non-emulsive stream of second fluid (118) to provide an interface (120) between said emulsion and said stream of second fluid (118); and in embodiments applying one or both of an electric (112a, 112b) and magnetic field across said interface (120) to alter a trajectory of a said droplet (114) of said emulsion to cause said droplet to coalesce with said stream of second fluid (118); and accessing said contents of said droplet (114) in said second stream (118).
    Type: Application
    Filed: October 16, 2008
    Publication date: April 19, 2012
    Inventors: Chris Abell, Wilhelm T.S. Huck, Daniel Bratton, Graeme Whyte, Luis M. Fidalgo
  • Patent number: 8119413
    Abstract: A method for solid material detection in a medium includes receiving an exhaust gas downstream with respect to a workpiece from which a photoresist material is removed. An electromagnetic circuit is configured to include the exhaust gas, the exhaust gas is excited with electromagnetic energy and an impedance value of the electromagnetic circuit is determined, wherein the impedance value corresponds to an amount of solid material within the exhaust gas.
    Type: Grant
    Filed: July 26, 2010
    Date of Patent: February 21, 2012
    Assignee: Axcelis Technologies, Inc.
    Inventors: Richard E. Pingree, Jr., Palanikumara Sakthivel, Mahesh Vanodia, Michael B. Colson
  • Patent number: 8105848
    Abstract: An embodiment of the invention relates to a device comprising (1) an array of electromagnetic elements comprising coils, metal cores, and metal core heads, and (2) a controller that is adapted to control a current for one or more coils individually, to vary the current for said one or more coils individually, to reverse the current for one or more coils individually, and to generate a specific magnetic flux distribution and gradient across two or more coils; wherein the metal core head is at one end of the coil and the metal core head has a geometry to create a desired magnetic flux, intensity and gradient, in a region of interest between two adjacent coils; further wherein the device is functionally coupled to a fluidic device to concentrate and transport magnetic particles in a fluid without fluidic movement of the fluid.
    Type: Grant
    Filed: October 8, 2010
    Date of Patent: January 31, 2012
    Assignee: Intel Corporation
    Inventors: Xing Su, Kenneth Schwartz, Liming Wang, David Schwartz, Mineo Yamakawa
  • Publication number: 20120018307
    Abstract: An oil cleaning device is provided with: at least a first electrostatic cleaner comprising at least one voltage source, and at least two metal plates connected to said voltage source; and at least one free radical sensor for determining the content and/or type of free radicals in the oil.
    Type: Application
    Filed: May 26, 2011
    Publication date: January 26, 2012
    Applicant: ANSALDO ENERGIA S. P. A.
    Inventors: Fabrizio D'AGOSTINO, Hans OVERGAAG
  • Patent number: 7914662
    Abstract: A portable apparatus for treating polluted water by electrocoagulation. The apparatus comprising at least two electrodes (1,2). The apparatus also includes a housing (4), electrically isolated from the at least two electrodes (1,2), to which the at least two electrodes (1,2) are fixed spaced apart from one another. When the at least two second electrodes (1,2) are at least partly submerged in the polluted water and provided with an electrical potential, one of the at least two electrodes (2) is sacrificial so as to provide ions to the polluted water.
    Type: Grant
    Filed: July 3, 2006
    Date of Patent: March 29, 2011
    Inventor: Vivian Noel Edward Robinson
  • Patent number: 7758738
    Abstract: A method of separating gaseous components, heavier liquid components and lighter liquid components of a stream including the steps of conducting the stream between spaced apart electrodes in a treatment vessel, supplying from a voltage source an AC voltage of at least one base frequency F1 to at least one of the electrodes to establish an electric field within the vessel through which the stream passes, modulating the frequency F1 of the AC voltage at a modulation frequency F2, and withdrawing separated gaseous components from an upper portion of the vessel, heavier stream components from a lower portion of the vessel, and lighter liquid components from an intermediate portion of said vessel.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: July 20, 2010
    Assignee: National Tank Company
    Inventor: Gary W. Sams
  • Patent number: 7759132
    Abstract: Methods for performing microfluidic sampling are provided. The method includes providing a substrate including an arrangement of first, second and third electrodes, wherein the second electrode is interposed between the first and third electrodes. The method additionally includes causing a fluid input to continuously flow to the first electrode and biasing the first, second and third electrodes to a first voltage to cause a portion of the fluid input to spread across the second and third electrodes. The method further includes biasing the second electrode to a second voltage different from the first voltage to form a droplet on the third electrode, the droplet being separate from the fluid input.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: July 20, 2010
    Assignee: Duke University
    Inventors: Michael G. Pollack, Vamsee K. Pamula, Richard B. Fair
  • Publication number: 20100084272
    Abstract: A portable apparatus for treating polluted water by electrocoagulation. The apparatus comprising at least two electrodes (1,2). The apparatus also includes a housing (4), electrically isolated from the at least two electrodes (1,2), to which the at least two electrodes (1,2) are fixed spaced apart from one another. When the at least two second electrodes (1,2) are at least partly submerged in the polluted water and provided with an electrical potential, one of the at least two electrodes (2) is sacrificial so as to provide ions to the polluted water.
    Type: Application
    Filed: July 3, 2006
    Publication date: April 8, 2010
    Inventor: Vivian Noel Edward Robinson
  • Publication number: 20100051463
    Abstract: Water treatment, reconditioning, and reclamation systems and methods are described. The systems utilize two treatment vectors. The first treatment vector is created by flowing electrical current through a first conductive rod. The second treatment vector is created by delivering a magnetic pulse by way of a second conductive rod. Water to be treated is exposed to the two vectors simultaneously, which is accomplished by creating relative motion between the conductive rods and the water, either by moving the conductive rods or by moving the water. The electric current of the first treatment vector and the voltage and frequency of the magnetic pulse of the second treatment vector may be reduced as the treatment process proceeds. During treatment, total dissolved solids (TDS) rise and congeal at the top of the water. The congealed TDS are removed from the water. An additional filtering process may be applied.
    Type: Application
    Filed: August 27, 2008
    Publication date: March 4, 2010
    Inventor: Andre Kostrzewa
  • Publication number: 20100038286
    Abstract: Performance of equipment, such as a desalter, in a refinery is monitored in real-time and on-line to minimize fouling of downstream equipment. Using an instrument to measure particles and droplets in-process allows monitoring of the various operations to optimize performance. Such measurement can also be used during crude oil blending to detect asphaltene precipitates that can cause fouling and can be used for monitoring other fouling streams.
    Type: Application
    Filed: December 18, 2007
    Publication date: February 18, 2010
    Inventors: Mark A. Greaney, Glen B. Brons, Chris A. Wright, Daniel P. Leta
  • Patent number: 7662268
    Abstract: The present invention discloses a method for measuring the zeta potential at the cylinder's outer surface. In the measuring cell, the cylinder is held coaxially inside a reference tube and a given solution is forced to flow through the annular flow channel between the cylinder and the reference tube. The streaming potential induced by the flow forced with a hydraulic pressure drop is measured to determine the zeta potential, ?m, of the cylinder's outer surface by using the following Equation, E _ ? ? ? P == - D ? ? ? k ? ( ? m + ? ref 2 ) ? F where D is the permittivity, ?ref is the zeta potential of the reference tube, ? is the viscosity of the solution, k is the electric conductivity of the solution, and F is a correction factor for the electrokinetic model. Moreover, this invention also discloses a system for measuring the zeta potential of the cylinder's outer surface.
    Type: Grant
    Filed: September 12, 2006
    Date of Patent: February 16, 2010
    Assignee: Chung Yuan Christian University
    Inventor: Ching-Jung Chuang
  • Publication number: 20090255601
    Abstract: A fluidic device, the fluidic device comprising a planar fluidic conduit for conducting a fluid, wherein the fluidic conduit has a plurality of fluidic disturbance features located along at least a section of the fluidic conduit for disturbing a laminar flow of the fluid along the section.
    Type: Application
    Filed: April 14, 2008
    Publication date: October 15, 2009
    Applicant: AGILENT TECHNOLOGIES, INC.
    Inventors: Martin BAEUERLE, Konstantin CHOIKHET
  • Publication number: 20090188799
    Abstract: An apparatus and method for electrochemically modifying the retention of a species on a chromatography material is disclosed. The apparatus comprises a housing having an effluent flow channel adapted to permit fluid flow therethrough. The effluent flow channel comprises chromatography material. The apparatus further comprises first and second electrodes positioned such that at least a portion of the chromatography material is disposed between the first and second electrodes, and fluid flow through the apparatus is between, and in contact with, the first and second electrodes.
    Type: Application
    Filed: April 2, 2009
    Publication date: July 30, 2009
    Applicant: Dionex Corporation
    Inventors: James M. Anderson, JR., Raaidah Saari-Nordhaus, Carl W. Sims, Yuri E. Gerner
  • Publication number: 20090065359
    Abstract: The invention describes a family of sensors for assaying macro-molecules and/or biological cells in solution. Each sensor has the form of a well (a hollow cylinder having a floor but no lid) or a trench whose walls comprise a plurality of GMR or TMR devices. Suitably shaped magnets located below each well's floor pull labeled particles into the well/trench and up against the inner wall where a field gradient orients them for optimum detection. Any unattached labels that happen to also be in the well/trench are removed through suitably sized holes in the floor.
    Type: Application
    Filed: September 11, 2007
    Publication date: March 12, 2009
    Inventor: Yuchen Zhou
  • Publication number: 20090045063
    Abstract: Disclosed are an apparatus and a method for detecting particles and microorganisms using a magnetic field. The apparatus comprises a magnetic sensor that is provided at an outside of a passage pipe and measures a magnetic field induced by fluid moving in the passage pipe; an electrode that is provided in the passage pipe so as to apply electric current having a predetermined frequency to the fluid moving in the passage pipe to measure impedance; and a signal processing unit that uses an intensity of the magnetic field measured by the magnetic sensor and the impedance measured by the electrode to determine concentrations of particles and microorganisms included in the fluid.
    Type: Application
    Filed: March 14, 2008
    Publication date: February 19, 2009
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Kyoung Ho KANG, Jung Joo HWANG, Jaechan PARK, Yunwoo NAM, Junil SOHN
  • Publication number: 20090026082
    Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.
    Type: Application
    Filed: December 17, 2007
    Publication date: January 29, 2009
    Applicant: Ion Torrent Systems Incorporated
    Inventors: Jonathan M. Rothberg, Wolfgang Hinz
  • Publication number: 20080302663
    Abstract: Disclosed herein is an electrostatic fluid filtration system suitable for removing sub micron insoluble contaminants known to cause varnish from fluids such as dielectric fluids. The electrostatic fluid filtration system is configured to remove both water and other contaminants from a target fluid (e.g. a dielectric fluid) and comprises a cabinet, a computer control unit, and one or more substantially cylindrical filtration units, including at least one of a water filtration unit and an electrostatic contaminant filtration unit. In the contaminant filtration unit, the target fluid flows radially through the filtration media that is positioned between the electrode plates in a generally horizontal flow pattern. This forces the target fluid to traverse multiple energy fields in a serpentine fashion and in a single pass through the contaminant filtration unit. After flowing through each layer of the filtration media, the target fluid is discharged from the electrostatic contaminant filtration unit.
    Type: Application
    Filed: June 8, 2008
    Publication date: December 11, 2008
    Inventor: Paul Jarvis
  • Patent number: 7384791
    Abstract: A method of analyzing blood includes delivering a blood sample to a test device, applying a spatially varying electric field to the blood sample to provide a depleted cell concentration in a portion of the blood sample, and sensing a property of the portion of the blood sample.
    Type: Grant
    Filed: January 21, 2004
    Date of Patent: June 10, 2008
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: David Tyvoll, Winthrop D. Childers, Kirk Norton, Bryan J. Johnson
  • Patent number: 7374603
    Abstract: Particle collection, transport, and detection systems are disclosed. The systems are uniquely adapted for collecting or concentrating particles from a flowing medium and then transporting the collected particles to a desired location or for subsequent analysis. Electrostatic traveling wave grids can be used in conjunction with sample concentrators.
    Type: Grant
    Filed: May 15, 2007
    Date of Patent: May 20, 2008
    Assignee: Palo Alto Research Center Incorporated
    Inventor: David Biegelsen
  • Patent number: 7373276
    Abstract: A method for quantitative evaluation of emulsion stability using Critical Electric Field (CEF) determinations over a range of conditions, such as a range of temperatures, demulsifier compositions, or demulsifier concentrations. The method includes determining the CEF for a series of emulsions that differ substantially only in their internal phase volume ratio. A plot of CEF values as a function of the inverse of the internal phase volume ratio is characterized by a linear slope. Using the slope, a theoretical CEF value can be determined by extrapolating to where the inverse of the internal phase volume ratio is about one. The slope for a given emulsion series is associated with the relative energy barrier to flocculation and the theoretical critical electric field for a given emulsion series is associated with the relative energy barrier to coalescence. Comparative studies are performed using this method.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: May 13, 2008
    Assignee: Champion Technologies, Inc.
    Inventor: Jannie Beetge
  • Patent number: 7351320
    Abstract: A method of augmenting the separation of immiscible heavier and lighter components of an emulsion including the steps of conducting the emulsion into a treatment vessel, providing an AC voltage source, employing from the source an AC voltage of at least one selected frequency F1 to establish at least one electric filed within the vessel through which the emulsion passes, and cyclically modulating the AC voltage with a method of modulation selected from: (a) amplitude modulation; (b) frequency modulation; and (c) combined amplitude and frequency modulation.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: April 1, 2008
    Assignee: National Tank Company
    Inventor: Gary W. Sams
  • Patent number: 7309442
    Abstract: A fluid treatment system for reducing odor, bacteria, and biological oxygen demand from a fluid having at least one tube, a control box, and a pump. The at least one tube has a plurality of conductors in electrical communication with the control box. The control box controls the level of electrical communication to the plurality of conductors and the flow rate of the pump. The principle use is for biomass material derived from animals, however other fluids will benefit from this invention. For example, fluids derived from plants and humans will benefit from this application.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: December 18, 2007
    Assignee: Elm Technologies, L.L.C.
    Inventors: Jamel Bourazak, Larry Coleman
  • Patent number: 7235123
    Abstract: Particle collection, transport, and detection systems are disclosed. The systems are uniquely adapted for collecting or concentrating particles from a flowing medium and then transporting the collected particles to a desired location or for subsequent analysis. Electrostatic traveling wave grids can be used in conjunction with sample concentrators.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: June 26, 2007
    Assignee: Palo Alto Research Center Incorporated
    Inventor: David Biegelsen
  • Patent number: 6860979
    Abstract: A method of augmenting the separation of immiscible heavier and lighter components of an emulsion including the steps of passing the emulsion into a treatment vessel, establishing at least one dual frequency electric field within the vessel and selectably varying the electric field at a frequency F1 modulated in intensity at a frequency F2 where F1 is greater than F2.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: March 1, 2005
    Assignee: National Tank Company
    Inventor: Gary W. Sams
  • Publication number: 20040069632
    Abstract: A device and method for generating drops. The drops are generated by applying an electrical potential to a set of feeding tips which have immiscible or poorly miscible liquids running through them.
    Type: Application
    Filed: July 31, 2003
    Publication date: April 15, 2004
    Inventors: Antonio Barrero Ripoll, Alfonso Ganan Calvo, Raul Cortijo Bon, Ignacio Gonzalez Loscertales
  • Patent number: 6706170
    Abstract: System for treating fluids, especially water, in a pipe to resist scale deposits from building up in the pipe, includes a field generating coil (10) mounted exteriorly of the pipe, an electronic circuit (14) for energizing the coil to develop an alternating electromagnetic field in the fluid, a sensor (18) for sensing a parameter related to the functioning of the system and for generating a parameter dependant signal, a feed back circuit for feeding back the parameter dependent signal to the electronic circuit to control the circuit, wherein the sensor comprises a field measuring coil (16) mounted exteriorly of the pipe near the field generating coil, the feed back circuit comprises the electronics which together with the measuring coil acts as a field strength meter.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: March 16, 2004
    Inventor: Jan Pieter De Baat Doelman
  • Publication number: 20030199745
    Abstract: This invention relates to methods for reducing the presence of a compound in an ionically conductive material, e.g., for use in iontophoretic devices, wherein the presence of the compound interferes with detecting a selected analyte. Removal of the compound can typically take place either during or after the manufacture of the ionically conductive material or an assembly comprising this material. Also disclosed are methods for generating selectively permeable barriers on the reactive faces of electrodes. Further, this invention relates to hydrogels comprising one or more biocides, as well as assemblies containing such hydrogels.
    Type: Application
    Filed: May 14, 2003
    Publication date: October 23, 2003
    Applicant: Cygnus, Inc.
    Inventors: Kim K. Burson, Michelle Van Wyhe, Jeffrey Pudlo, Michael Reidy, Pravin Soni, Christopher Uhegbu, Prema Vijayakumar
  • Patent number: 6468410
    Abstract: An apparatus that is useful for evaluating and optimizing electrochemical processes and for electrochemically characterizing materials includes a base or substrate carrying a plurality of electrodes, at least one housing member that is secured to the base or substrate to define an electrochemical cell volume for holding an electrolyte in contact with the plurality of electrodes carried on the base, and a counter electrode disposed in the cell volume. The apparatus may be used for rapidly evaluating various parameters that influence electrochemical deposition processes, electrolytic processes and electrochemical cell performance.
    Type: Grant
    Filed: May 17, 2000
    Date of Patent: October 22, 2002
    Assignee: Eveready Battery Company, Inc.
    Inventor: Scott W. Donne
  • Publication number: 20020029970
    Abstract: This invention relates to the enhancement of chemical reactions by applying a high frequency electric field to a material. The frequency and amplitude of the electric field are selected in accordance with the properties of the reacting components in the bulk of chemical reactor. In general, the high frequency range is determined by the dielectric properties of reactant(s), that is, at any given temperature, when, for example, the specific conductivity starts to grow from its low frequency value. Typically, frequencies in the range of 100 kHz to 200 MHz or greater are suitable for the enhancement of the reactions. An electric field of any shape having Fourier components that when applied to a chemical process exhibits growth in the real part of conductivity relative to the low frequency value is of particular importance.
    Type: Application
    Filed: August 15, 2001
    Publication date: March 14, 2002
    Inventors: Alexander Joseph Babchin, Jian-Yang Yuan, Ezra Eddy Isaacs, Haibo Huang, Ross Sam Chow, Richard Anthony McFarlane, Dmytro Vassily Prudkyy
  • Patent number: 6319705
    Abstract: A microchip device for electrophoresis includes not only a microchip having a separation flow route for separating a sample electrophoretically and an electrical power source for applying a migration potential difference along the separation flow route but also a grating for dispersing light received from each position within a specified range along the separation flow route in a direction perpendicular to the separation flow route, a two-dimensional light-receiving device such as charge-coupled devices for receiving dispersed light from the grating at light-receiving positions which are two-dimensionally distributed parallel to and and perpendicular to the separation flow route, and a data processor for receiving measured values obtained repeatedly by said two-dimensional light-receiving means and carrying out multi-point averaging on the measured values for each of the light-receiving positions.
    Type: Grant
    Filed: February 4, 2000
    Date of Patent: November 20, 2001
    Assignee: Shimadzu Corporation
    Inventor: Hiroshi Tanaka
  • Publication number: 20010035342
    Abstract: A system for delivering electromagnetic energy into a solution using a delivery apparatus to modify its characteristics. Preferred systems are described that deliver electromagnetic energy into a target solution for modifying its characteristics by first treating a primary solution, e.g., water or any hydrogen bonded liquid, and then causing the primary solution to be proximate to the target solution. The treated secondary solution improves the performance of various processes including: scale control in water heater systems, printing ink treatment, de-inking of pulp paper, etc.
    Type: Application
    Filed: March 1, 2001
    Publication date: November 1, 2001
    Inventors: Dwain E. Morse, James H. Cook, Thomas G. Matherly
  • Publication number: 20010017264
    Abstract: Method for separating the constituents of a dispersion In order to improve the efficiency of the separation of an insulating liquid (3) from a dispersum (4), in particular of water dispersed in oil, the electric conductivity (&sgr;s) of a dispersion (S) having the dispersion constituents (3, 4) is measured continuously or discontinuously. An optimum frequency (f) is calculated as a function of this conductivity. Pulsations of at least one pulsating electric field are thereby prescribed, this dispersion (S) being led through said field. This frequency (f) is preferably in the frequency range of >60 Hz-1 kHz. An electric field with a separating AC voltage (U3) can be arranged downstream of an electric field of a pulsating separating voltage (U2) of adjustable frequency (f) in the flow direction of the dispersion (S), and an electric field of a pulsating charging DC voltage (U1) can be arranged upstream.
    Type: Application
    Filed: December 20, 2000
    Publication date: August 30, 2001
    Inventors: Norbert Klippel, Ole-Morten Midtgard
  • Patent number: 6255551
    Abstract: A process treats contaminated media and comprises detecting a non-uniform contaminated media property selected from electrical conductivity or electroosmotic permeability; and selectively applying an electric field to the contaminated media to effect the process in a selected area of the contaminated media.
    Type: Grant
    Filed: June 4, 1999
    Date of Patent: July 3, 2001
    Assignee: General Electric Company
    Inventors: Andrew Philip Shapiro, Joseph James Salvo