Abstract: Orally Active androgens are derivative of 7&agr;-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl; R2 is selected from the group consisting of (C2-3)alkyl, isopropyl, (C2-3)1-alkenyl, isopropenyl, 1,2-proandienyl, or (C2-3)1-alynyl, each optionally substituted by halogen; or R2 is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2)alkyl, or halogen; R3 is hydrogen, (C1-2)alkyl, or ethenyl; R4 is (C1-2)alkyl; R5 is hydrogen, or (C1-15)acyl; and the dotted lines indicate optional bonds.
Type:
Grant
Filed:
September 24, 2001
Date of Patent:
June 29, 2004
Assignee:
Akzo Nobel N.V.
Inventors:
Jaap van der Louw, Dirk Leysen, Roberta Burma Bursi
Abstract: Novel, orally active androgens are 7&agr;-substituted &Dgr;14-nandrolone derivatives. The compounds satisfy the general formula:
wherein
R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C1-6) acyl;
R2 is selected from the group consisting of (C2-4) alkyl, (C2-4) alkenyl, or (C2-4) alkynyl, each optionally substituted by halogen; or
R2 is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2) alkyl, or halogen;
R3 is hydrogen, (C1-2) alkyl, or ethenyl;
R4 is (C1-2) alkyl;
R5 is hydrogen, or (C1-15) acyl;
and the dotted lines indicate optional bonds.
Type:
Grant
Filed:
July 31, 2001
Date of Patent:
April 1, 2003
Assignee:
Akzo Nobel N.V.
Inventors:
Hubert Jan Jozef Loozen, Dirk Leysen, Jaap van der Louw
Abstract: A game or gift shaped as a simulated matchbook cover containing one or more tear-out strips anchored to the lower end of the cover in essentially the same fashion as matches in a conventional pocket matchbook. The strips are elongated panels which can be torn from the cover, and which bear messages on one or both sides. Alternatively, the strips are tear-out envelopes in which messages or small gifts are inserted. In one form, a spinner is rotatably secured to the cover, and the resting position of the spinner designates one or more specific strips to be torn from the cover.
Abstract: A safety matchbook including a matchbook having a front and a back, a carrier between the front and back, matches extending from the carrier, and a striking surface on which the matches can be struck, the matchbook being arranged for exposure of less than all the matches for selecting one of the matches, and for enclosing the matches while a match is being struck on the striking surface.