Abstract: Orally Active androgens are derivative of 7&agr;-methyl-19-nortestosterone. The compounds satisfy formula (I) wherein R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6)alkyl, or (C1-6)acyl; R2 is selected from the group consisting of (C2-3)alkyl, isopropyl, (C2-3)1-alkenyl, isopropenyl, 1,2-proandienyl, or (C2-3)1-alynyl, each optionally substituted by halogen; or R2 is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2)alkyl, or halogen; R3 is hydrogen, (C1-2)alkyl, or ethenyl; R4 is (C1-2)alkyl; R5 is hydrogen, or (C1-15)acyl; and the dotted lines indicate optional bonds.
Type:
Grant
Filed:
September 24, 2001
Date of Patent:
June 29, 2004
Assignee:
Akzo Nobel N.V.
Inventors:
Jaap van der Louw, Dirk Leysen, Roberta Burma Bursi
Abstract: Novel, orally active androgens are 7&agr;-substituted &Dgr;14-nandrolone derivatives. The compounds satisfy the general formula:
wherein
R1 is O, (H,H), (H,OR), NOR, with R being hydrogen, (C1-6) alkyl, or (C1-6) acyl;
R2 is selected from the group consisting of (C2-4) alkyl, (C2-4) alkenyl, or (C2-4) alkynyl, each optionally substituted by halogen; or
R2 is cyclopropyl, or cyclopropenyl, each optionally substituted by (C1-2) alkyl, or halogen;
R3 is hydrogen, (C1-2) alkyl, or ethenyl;
R4 is (C1-2) alkyl;
R5 is hydrogen, or (C1-15) acyl;
and the dotted lines indicate optional bonds.
Type:
Grant
Filed:
July 31, 2001
Date of Patent:
April 1, 2003
Assignee:
Akzo Nobel N.V.
Inventors:
Hubert Jan Jozef Loozen, Dirk Leysen, Jaap van der Louw
Abstract: A disk cartridge including: a case for storing a disc-like disk medium rotatably, shutter members for opening or closing an opening for access to the disk medium provided in the case, and a covering member for storing the shutter members in a gap with respect to the case. Cleaning members for wiping the shutter members are provided on the outer surface of the case and/or the inner surface of the covering member. Also, a drive device for recording/replaying information on the disk medium. A spindle shaft for holding the disk medium is provided, which can be rotated by a predetermined rotational amount while having the recording surface of the disk medium contacted with a cleaning member provided on the inner surface of the case.