Abstract: In alternative embodiments the invention provides compositions, e.g., pharmaceutical compositions and preparations, formulations, kits and other products of manufacture, e.g., exemplary drug combinations packaged together or separately in blister packs, lidded blisters or blister cards, or wrapped in paper, plastic or cellophane wrappers (e.g., a shrink wrap), comprising a combination regimen of at least two active ingredients designed to diminish systemic inflammation by targeting (inhibiting) two different, but convergent, signaling pathways, i.e., the sympathetic nervous system and the lipid-derived autacoid system; and methods for making and using these compositions. In alternative embodiments, the compositions of the invention (e.g., the combination of drugs) are used to ameliorate, diminish, treat, block or prevent an inflammatory response secondary to an infection, e.g., a viral infection and/or a reactivation.

Abstract: The present invention is a method of treating antifolate neurotoxicity in a mammal suffering from or at risk of developing antifolate neurotoxicity, which comprises administering to the mammal a therapeutically effective amount of an NMDA antagonist, or a pharmaceutically acceptable salt thereof.

Abstract: A daily blister card housing a unit dose includes a back side and a front side opposite the back side. The front side includes a manufacturer indicator visible on the front side. A face has an outer periphery and a total planar area bounded by the outer periphery. One or more blisters extend outwardly at the face that contain at least three unit doses that are visible from outside the one or more blisters. Each of the one or more blisters includes a shoulder contacting a cavity backing surface and a projected cavity area bounded by the shoulder that is projected onto the cavity backing surface. A total projected cavity area of the one or more blisters is no more than about 45 percent of the total planar area bounded by the outer periphery.

Abstract: A secure package (1) for drugs, blocks access to the drugs such that, to gain access to the drugs, the user must execute two simultaneous actions. When one of the actions is interrupted, access is rendered impossible. The secure package includes a case (2), a blister (3), and an elastic biasing system (4). The blister (3) is a cellular card pack for dispensing pills. The blister (3) is mobile and can be moved in translation in the case (2) by being slid on its base wall (16). Thus, the blister can take up two positions, namely an initial rest position, wherein the position of the cells (10) does not correspond to holes (19) formed in the base wall (16) and a so-called active position, wherein the cells (10) are in a position corresponding to the holes (19) in the base wall (16).

Abstract: A method is disclosed of treating acute, sub-acute or chronic constipation in a patient having a condition requiring such treatment. The method includes administering a lipase inhibitor.

Abstract: A water- and oxygen-occlusive pack is described. The pack encloses an inert atmosphere containing medicinal tablets, wherein the tablets contain buprenorphine or a salt or ester thereof.

Abstract: There is shown in three embodiments a pill blister pack container for holding a pill blister pack. The container having a first portion highedly attached to a second portion. The first portion being sized to fit within the second portion when the container is closed. Both the first and second portions have defined side walls and a front wall. In addition, the first portion includes flanges in the side walls that engage apertures in the second portion to lock the two portions. Furthermore, at least one support post extends between the two portions.

Abstract: A pharmaceutical product supply is disclosed in the form of a container, a pharmaceutical product receiver, pharmaceutical product, an adhesive, and at least one release liner. The pharmaceutical product receiver includes a plurality of receptacles for pharmaceutical product. The container is initially disposed in a first configuration where all of the pharmaceutical product receiver receptacles may be accessible. The container is thereafter disposable in a second configuration where no covering for any of the pharmaceutical product receiver receptacles is accessible through any openable access incorporated by the container. One or more release liners may be moved to expose adhesive for disposing and retaining the container in its second configuration. The noted second configuration of the container facilitates disposal of the pharmaceutical product supply (e.g.

Abstract: The child-resistant medication container includes: a housing having an open end, a support slidably mounted in the housing for supporting medication, first locking element for locking the support in the housing and for unlocking the support so that the support may be slid to the outside of the housing through the open end, the first locking element including a first locking member coupled to the housing and a second locking member coupled to the support, the first and second locking members being engageable with each other, and at least one button operable to act on the first locking element, the at least one button including a first button operable to disengage the first and second locking members, second locking element for maintaining engagement between the first and second locking members, and a second button operable to act on the second locking element to permit disengaging the first and second locking members by operating the first button.

Abstract: A dispensing system and method of use having a package and insert containing clinical information, wherein the package insert cannot be easily discarded, lost or damaged. The package insert is further configured so as to not impede closing of the packaging. The dispensing system further provides that mediation retained in the package cannot be removed from the package without partially removing the insert configured as an educational slider, such that the access to the medication is a ‘two-step’ process. In a further aspect, the dispensing system provides dosage instructions and other clinical information specific to the medication. The dispensing system may include sample or prescribed medication. Alternatively, the dispensing system may include a discount price coupon or other promotional material that is only accessible when an educational package insert is moved to provide access to the coupon or promotional material.

Abstract: A pharmaceutical package and an associated method are provided that is child resistant, but that may be readily accessible for users having arthritis or otherwise having limited mobility in their fingers. The pharmaceutical package includes a housing and a card carrying medication that is slidably disposed at least partially within the housing such that the at least one medication is positioned within the housing. The pharmaceutical package also includes an engagement member configured to engage the card in an instance in which the card is disposed within the housing. For example, the card may define an opening and the engagement member may be configured to extend into the opening defined by the card when the card is in the housing. The pharmaceutical package also includes a twistable actuator configured to disengage the card and the engagement member in response to rotation of the twistable actuator relative to the housing.

Abstract: A multiple-use dispenser (1) for articles contained in blister-type packages (100), in particular for pharmaceutical products such as pills, tablets, capsules and like articles, comprising a housing (2) with at least one opening for dispensing an article from a blister-type package contained therein, The housing (2) comprises a front and a rear sheet (3,4) which are interconnected with each other along their longitudinal edges and have a closed end (5) and an open end (6) on opposite longitudinal ends thereof. The front and rear sheets (3, 4) each are provided with at least one opening (30,40) which are in permanent registry with one another. A shutter sheet (9) is provided within the housing (2) and adapted to be moved longitudinally from a first end position, in which the openings (30, 40) are closed by the shutter (9) to a second end position, in which an aperture (90) of the shutter sheet (9) is in registry with the openings (30, 40) in the front and rear sheets (3, 4).

Abstract: A slide card for selective insertion and withdrawal from a sleeve includes a base panel, a locking panel and at least one embossment. The locking panel is integrally formed with the base panel and hingedly connected to one of the opposing end edges of the base panel to engage at least part of the sleeve to lock the base panel in the sleeve. The locking panel extends from the one of the opposing end edges of the base panel to its free end edge that is located opposed to the one of the opposing end edges of the base panel. The at least one embossment is formed on one of the opposed surfaces of the base panel. The at least one embossment projects from the one of the opposed surfaces of the base panel and is spaced apart from receiving blisters on the base panel.

Abstract: In alternative embodiments the invention provides compositions, e.g., pharmaceutical compositions and preparations, formulations, kits and other products of manufacture, e.g., exemplary drug combinations packaged together or separately in blister packs, lidded blisters or blister cards, or wrapped in paper, plastic or cellophane wrappers (e.g., a shrink wrap), comprising combinations of beneficial ingredients that in alternative embodiments are serviceable as therapies or palliatives for treating, preventing or improving conditions, states and disease symptoms involving the use of targeted protein kinase inhibitors such as Multi-Kinase Inhibitors (MKIs) or Epidermal Growth Factor Receptor (EGFR) Inhibitors (EGFRIs), or the use of other oral oncolytics, such as capcitabine or erlotinib, known to be associated with drug-induced dermatological toxicity, e.g.

Abstract: The present invention provides a blister package including a blister tray having a plurality of upwardly opening blister depressions. A plurality of consumable products are provided where each blister depression supports one of the plurality of consumable products. A blister cover overlies and encloses the blister depression. The cover is sealed to the tray at a depression boundary about each depression. Each blister depression includes a tapered wall for urging the consumable product out from the blister depression at a location at the blister boundary upon manual exerted on the depression.

Abstract: A packaging blank includes a first panel and a second panel. The first panel defines at least one blister aperture and at least one tool portion. The second panel defines at least one tab strip and at least one tool access portion. The at least one tab strip is at least partially severable from the packaging blank. The at least one tool access portion is substantially completely severable from the packaging blank. The first panel and the second panel are configured to be positioned relative to one another in a face contacting arrangement such that a first portion of a given tool portion is to be operably aligned with a corresponding tool access portion. As such, the first portion of the given tool portion thereby is capable of being accessed by a tool via the corresponding tool access portion.

Abstract: A childproof and senior friendly packaging container having a housing that defines a chamber for removably receiving a blister card or sheet. The blister sheet includes a flap on its end that is designed to engage a flap extending into the chamber of the housing to retain the blister card within the housing in an extended position. A node on the blister card flap is sized to fit within a slot or hole on the housing to retain the blister card in a stored position.

Abstract: Provided is a mount sheet (12) affixed to a PTP sheet (50) which accommodates a product, such as a tablet (53) and is formed by punching out a blank sheet. The mount sheet (12) includes a first surface (14) to be placed on a surface of the PTP sheet (50) from which the projecting portion 52a is projecting, multiple holes (16) formed in the first surface 14 and in which the projecting portion (52a) is placed, and a second surface (24) which continues from the first surface (14) via a folding line (26) and is to be folded on the opposite surface of the PTP sheet (50). The second surface (24) has a rupturable line (28) formed at a position to face the projecting portion 52a when folded and placed on the PTP sheet (50). An ejector tool (56) is provided which is affixed to the third surface 36 on a surface to be folded over the first surface (14) and has a pressing projection (60) projecting toward the PTP sheet (50).

Abstract: The present invention relates to a child safe packaged-product system with multi-operational access control. The invention further relates to packaged-product system that facilitates interaction with the user so as to render child safe state of the package after use. The synergistic operational combination of the said package holding provision, package fixing provision, an assembly of the package and package fixing provision operably connected by the said restrictive means results in a multi-operational access control to access the package after the completion of the child resistant activity obviating the problem of package access as a part of the child resistant activity. Further provision of the said means to remind/alert user of reengaging/repositioning the package in the child-safe state after use renders child resistant state to the package after use enhancing the effectiveness of the child resistant function of the package.

Abstract: Tamper evident devices and methods including devices that can be used with pill bottles and other packages to provide evidence of tampering by an unauthorized user are provided.

Abstract: A blister pack for use with inhalation therapy inhalers comprises an elongate bottom element having an overlying top element defining a plurality of spaced top crowned areas containing powder or liquid medications or drugs.

Abstract: A book-like packaging structure for receiving at least one blister pack having at least one receptacle. The book-like packaging structure includes at least one inner blister pack retainer for receiving the at least one blister pack, the at least one inner blister pack retainer having an inner edge, an outer edge, a first retainer portion and a second retainer portion, said second retainer portion adjacent an inner spine panel having a width equal to or greater than the depth of the at least one receptacle; and a cover for enclosing the at least one inner blister pack retainer, the cover having a first cover portion having an inner edge, a second cover portion having an inner edge and a spine, the spine joined to the inner edge of the first cover portion and the inner edge of the second cover portion, wherein the inner spine panel rests against the spine such that the inner edge of the at least one inner blister pack retainer is positioned adjacent to the spine of the cover.

Abstract: A folding box with a blister pack held therein is produced from a one-piece blank, having a first tab which starts integrally from a narrow side wall and in the use position inside the folding box rises obliquely inwards from this edge toward the opposite wall and is supported resiliently against the latter. A second tab is bent back from the support point of the first tab and in the use position comes to lie between the first wall and the first tab or the second wall, and in turn carries at its edge a locking tab which in the use position engages in a hinged fashion between two blister cavities or cavity rows arranged one behind the other in the insertion direction, and thereby secures the blister pack in locking fashion without the need for beads or other deformations that affect the surface on the folding box.

Abstract: The present invention discloses an adjustable medication blister package that provides custom patient schedule of medications based on a future exam time. The adjustable medication blister package has multiple medications individually enclosed in blister packs where each blister pack is indicated with correct time to take each medication. A timing indicator which is populated with times is placed behind a base card where individual correct times can be seen through indicator apertures once a user selects the time of the future event using an adjustable time selector.

Abstract: A child and bite resistant package having a tray and a plurality of spaced apart cavities that are formed therein is provided. A sheet material overlies the tray such that a product disposed in a cavity is enclosed and sealed therein. The sheet material includes a plurality of zones of weakening that are each disposed above a corresponding cavity. Each of the zones of weakening is formed by a plurality of microperforations that are formed in the sheet material. To access a product, the product is pushed against the lidding in the zone of weakness with sufficient force to rupture the lidding. Since the majority of the surface area above each compartment is non-rupturable, the compartments are difficult to access by a child by either hand manipulation or biting.

Abstract: The present invention is a novel, theft-resistant, and senior-friendly packaging for consumer and retail products that is cheap and easy to manufacture. The packaging is designed to prevent individuals from gaining access to the enclosed product through tampering with the packaging while at the same time meeting or exceeding federal child-resistant and senior-friendly guidelines. The packaging incorporates plastic material and multiple cuts to be tear-resistant and to halt the propagation of a tear, if one should occur.

Abstract: A blister and package system made of a blister card and an outer package with unique interacting locking mechanisms. The blister card or strip is inserted into the outer package or sleeve and locks immediately without having to further process the outer package or the blister card or strip. The user is able to expose the blisters from the outer package by disengaging the lock. The blister card or strip includes a formable, pliable sheet material, into which one or more individual cavities or blisters are formed. The separated cavities are loaded with product and sealed with one or more layers of puncturable or tearable sheet material, such as aluminum foil. The blister card or strip contains a plastic rivet assembly that forms an interference mechanism. The rivet is trapped by an internally formed panel and stopped by a catch flap included in the outer package.

Abstract: A package for dispensing pills that is childproof yet senior-friendly. The package includes a housing, which may be substantially tear-resistant, that encloses one or more blisters. In one embodiment, the cavities of the blisters are positioned such that pills or other objects are dispensed into a chamber. An object dispensing opening associated with the chamber is selectively covered by a childproof closure member. In various embodiments, the childproof closure may be rotationally or slidingly connected to the package to move between a closed position and an open position to selectively permit dispensing of the objects.

Abstract: The invention relates to methods for decreasing adverse events associated with pirfenidone (5-methyl-1-phenyl-2-(1H)-pyridone) therapy. The invention discloses an optimized dose escalation scheme that results in the patient having increased tolerance to adverse events associated with the administration of pirfenidone. The invention also discloses a starter pack that may be used in conjunction with the dose escalation scheme.

Abstract: The subject invention provides a pharmaceutical composition containing laquinimod or a pharmaceutically acceptable salt thereof, and a compound of N-ethyl-N-phenyl-1,2-dihydro-4,5-di-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide or a salt thereof.

Abstract: The present invention provides highly purified omega-3 fatty acid formulations. Certain formulations provided herein have greater than 85% omega-3 fatty acids by weight. Certain other formulations provided herein contain EPA and DHA in a ratio of from about 4.01:1 to about 5:1. The invention also provides methods of using the dosage forms to treat a variety of cardiovascular, autoimmune, inflammatory, and central nervous system disorders by administering a formulation of the invention to a patient in need thereof.

Abstract: A press-through package for articles such as medicines which can reliably prevent a recipient from accidentally swallowing the whole package without opening it, including solid medicines M stored in a plurality of pockets of a base sheet one by one and the pockets sealed by a cover film having attached to the rear surface of the base sheet, wherein the entire package of the press-through package is made in a cylindrical form which cannot allow a recipient from accidentally swallowing and from which the medicines can be taken out easily.

Abstract: A lockable product package assembly containing an outer sleeve and an inner tray slidably engaged within the outer sleeve. The outer sleeve includes a tray locking recess disposed in an inner surface of a first wall of the outer sleeve. The inner tray includes a product portion with a protruding release button and a locking portion integrally connected to the product portion. The locking portion of the tray is configured to engage with the tray locking recess in the outer sleeve, so as to prevent sliding movement of the tray relative to the sleeve, when the inner tray is fully inserted into the outer sleeve. To release the tray, the protruding release-button on the inner tray is depressed, which disengages the locking portion of the tray from the locking recess in the outer sleeve, so as to permit sliding movement of the tray relative to said outer sleeve.

Abstract: A blister and package system made of a blister card and an outer package with unique interacting locking mechanisms. The blister card or strip is inserted into the outer package or sleeve and locks immediately without having to further process the outer package or the blister card or strip. The user is able to expose the blisters from the outer package by disengaging the lock. The blister card or strip includes a formable, pliable sheet material, into which one or more individual cavities or blisters are formed. The separated cavities are loaded with product and sealed with one or more layers of puncturable or tearable sheet material, such as aluminum foil. The blister card or strip contains a plastic rivet assembly that forms an interference mechanism. The rivet is trapped by an internally formed panel and stopped by a catch flap included in the outer package.

Abstract: A child and bite resistant package having a tray and a plurality of spaced apart cavities that are formed therein is provided. A sheet material overlies the tray such that a product disposed in a cavity is enclosed and sealed therein. The sheet material includes a plurality of zones of weakening that are each disposed above a corresponding cavity. Each of the zones of weakening is formed by a plurality of microperforations that are formed in the sheet material. The plurality of microperforations, and hence, each zone of weakening covers from about 5 to 90% of the surface area of the sheet material that overlies each of the individual compartments. To access a product, the product is pushed against the lidding in the zone of weakness with sufficient force to rupture the lidding. Since the majority of the surface area above each compartment is non-rupturable, the compartments are difficult to access by a child by either hand manipulation or biting.

Abstract: A blister pack comprises a bottom film and a top film for forming a plurality of film containers (1) that can be separated from one another by perforations (10), each having one accommodating chamber (2) for a filling, particularly a pharmaceutical active substance formulation, the accommodating chambers (2) being arranged around the peripheral boundary of the blister pack (7). The centre of the blister pack (7) is formed by a detachable film section (4), after the removal of which an opening region (5) is available for opening the accommodating chamber (2).

Abstract: A child-resistant package includes a support for supporting hazardous material in use; a structure for selectively blocking access to hazardous material supported by the support, with the support being movable between a secured position in which access to the hazardous material is blocked and an access position in which the hazardous material is accessibly clear of the structure; at least one latch member movable between an engaged state and a disengaged state in which the support is allowed to move out of the secured position toward the access position; and a tab member movable with respect to the structure in a second direction different to the first direction, the tab member being coupled to the support to effect movement of the support out of the secured position in the first direction when the latch member is in the disengaged state.

Abstract: Disclosed are blister package apparatuses and methods for use with tablets such as soft or breakable tablets that cannot be forced through a push-through layer. Specifically, a package for soft tablets can include a pair of blister strips, each blister strip having a plastic sheet, a plurality of recesses formed in the plastic sheet, and a peel-away backing layer for covering the recesses. A plurality of support posts can secure the blister strips together, and a spacer element can extend from one of the blister strips towards the other blister strip, the spacer element extending between two or more of the recesses for maintaining the blister strips in a spaced-apart configuration. The plurality of recesses formed in each blister strip can be offset with respect to the recesses formed in the other blister strip such that the recesses of one blister strip can nest between the recesses of the other.

Abstract: There is shown in three embodiments a pill blister pack container for holding a pill blister pack. The container having a first portion highedly attached to a second portion. The first portion being sized to fit within the second portion when the container is closed. Both the first and second portions have defined side walls and a front wall. In addition, the first portion includes flanges in the side walls that engage apertures in the second portion to lock the two portions. Furthermore, at least one support post extends between the two portions.

Abstract: A blister pack for dispensing pills that is childproof yet senior-friendly. The blister pack includes a housing, which may be substantially tear-resistant, that encloses one or more blisters contained on a blister sheet. In one embodiment, the cavities of the blisters are positioned such that pills or other objects are dispensed into a chamber. A neck extends outward from the chamber to permit a childproof cap to be removably attached thereto to permit the selective dispensing of the pills in a controlled fashion. In another embodiment, the blister pack may include a chamber for dispensing a first type of pill and a plurality of blisters not aligned with the chamber for dispensing a second type of pill.

Abstract: The present invention is related to pharmaceutical compositions of one or more tiacumicins that exhibit improved stability, and methods of treatment using such formulations. The formulations contain one or more tiacumicins, such as difimicin, and one or more antioxidants, such as butylated hydroxytoluene, and, optionally, one or more pharmaceutically acceptable excipients.

Abstract: A storing and dispensing system (10) includes a first sliding element (12) and a sleeve (14). The first sliding element (12) has a base configured to hold at least one article, and the base incorporates a flange portion (71a). The sleeve (14) further includes a first side (16) or (18), an open end, and at least one guide rail (40). The first side (16, 18) is matingly connected to a second side (the other of 16, 18) to form a void for receiving the sliding element (12). The open end is configured to permit the sliding element (12) to translate between a first position and a second position. The at least one guide rail (40) includes a first retaining edge (42), positioned within the void, to cooperatively contact the flange 71a.

Abstract: A blister package is defined for retaining product. The package is formed from a receptacle substrate having a planer sealing flange and at least one receptacle hollow for retaining product therein. A top layer is provided, covering the receptacle hollow with a portion overlapping and sealed to the sealing flange. A score pattern is formed in the top layer for promoting propagation of a tear upon forcing product from receptacle hollow against the top layer. The score pattern is defined by a plurality of rows of parallel straight lines aligned with the receptacle hollow. In addition, a plurality of spaced curved or bowed score lines are provided. The curved or bowed score lines transversely intersect the rows of straight lines above the receptacle hollow.

Abstract: A blister and package system made of a blister card and an outer package with unique interacting locking mechanisms. The blister card or strip is inserted into the outer package or sleeve and locks immediately without having to further process the outer package or the blister card or strip. The user is able to expose the blisters from the outer package by disengaging the lock. The blister card or strip includes a formable, pliable sheet material, into which one or more individual cavities or blisters are formed. The separated cavities are loaded with product and sealed with one or more layers of puncturable or tearable sheet material, such as aluminum foil. The blister card or strip contains a plastic rivet assembly that forms an interference mechanism. The rivet is trapped by an internally formed panel and stopped by a catch flap included in the outer package.

Abstract: A child-resistant package (100) is formed from a sleeve (14) comprising a top (16) and a base (18), at least one of which is an outer wall of the sleeve (14). A release mechanism (20) for facilitating access to the contents of the package (100) is disposed in the outer wall (16). A decoy cover (60) having at least one outermost panel (62) is disposed in relation to the outer wall (16) to obscure the release mechanism (20). The package (100) may include an insert (12) that is held within the sleeve (14) by a locking mechanism that is disengaged by the release mechanism (20). The decoy cover (60) is attached to the outer wall (16) in a manner that facilitates repeated successive removal and reattachment of the decoy cover (60). The decoy cover (60) may further include one or more additional panels (64) disposed in flat-face condition with the outermost panel (62).

Abstract: A carded package includes a front card bonded to a rear card with a blister card captured therebetween. The blister card has upstanding blister compartments projecting through openings of the front card. The rear card extends over an opposite face of the blister card and is a laminate including a tear-resistant polymeric layer bonded to a paperboard layer. The polymeric layer extends adjacent the blister card and the paperboard layer of the laminate extends remote from the blister card forming an exposed surface of the rear card. The rear card includes perforations aligned behind the blister compartments. The perforations include a first set of perforations cut entirely through the paperboard and polymeric layers and a second set of perforations cut into the paperboard layer and not into or entirely through the polymeric layer. A method of assembling a carded package is also disclosed.

Abstract: A child-resistant package including two panels having one or more blister apertures and a particular manner of accessing the product within the blister apertures. One manner of accessing the product involves applying pressure to punch tabs defined by staggered perforations. Another manner of accessing the product uses tooled access slots designed to receive a tool to peel away tab strips to facilitate product access. Yet another manner of accessing utilizes tab strips, one or more folding lines and one or more crevice forming lines where the crevice forming lines are designed to receive a tool used to obtain access to the tab strips, and thus, facilitate access to the products. Still another uses dual tabs that need to be sequentially peeled away from the child resistant package housing to facilitate access to the product contained.

Abstract: A package includes a case and a card coupled to the case.

Abstract: A container is disclosed for housing a tray or blister pack. The container includes a shell (40) with an internal volume for holding the tray or blister pack, and a cover (10) with a base (11), hinge (13), and lid (12) for enclosing the shell (40).

Abstract: A medicament dispensing device comprises (a) at least one container adapted for accommodating and dispensing at least one elongate packagible elongate blister pack carrying a plurality of blisters containing the medicament; (b) transporting means adapted for transporting the blister pack toward opening of the container; (c) dispensing means adapted for releasing a fragment of the blister pack bearing a predetermined number of the blisters from the container through the opening to a patient; and (d) controlling means adapted for identifying the patient before dispensing the blister to the patient, activating the dispensing means, recording actions of dispensing. The substrate is foldable and configured to be folded within the container. In the folded configuration, non-foldable portions bearing the blisters face each other.