Test (e.g., Diagnostic Or Indicator) Patents (Class 206/569)
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Patent number: 4932081Abstract: A system is provided for easing the placement of the final screw cap onto a sputum collection container so as to avoid dropping the cap or spilling the specimen in the container onto the hands of the user. An opening is provided in the side wall of the outer protective body of the system so as to gain access to the cap held wedged therein. The wedging action holds the screw cap in place while the user rotates the specimen container to cause cooperation between the screw threads of the screw cap and the associated sputum collection container.Type: GrantFiled: August 11, 1989Date of Patent: June 12, 1990Assignee: Becton, Dickinson and CompanyInventor: James A. Burns
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Patent number: 4914034Abstract: Disposable test packs for monitoring the efficacy of steam or ethylene oxide sterilization cycles includes a fiber board housing for a biological indicator. The housing includes two end sections and a midsection. Each end section includes an outer tube and a longer inner tube. The open end of the outer tubes abut the opposing open ends of the midsection to define a seam or gap. The inner tube extends past the seam and telescopes into the midsection. The seam and the close tolerance between the inner tube and the midsection provide a tortuous path for the entry of sterilant into the interior of the housing. The tortuous path has a moisture absorbent surface and is dimensioned to promote intimate contact between the sterilant and the absorbent surface. A second path of entry is provided in the embodiment adapted for use in monitoring ethylene oxide sterilization processes only. A midsection can be made of a transparent, sterilant impermeable material to permit observation of the interior of the housing.Type: GrantFiled: December 22, 1988Date of Patent: April 3, 1990Assignee: American Sterilizer CompanyInventors: Jon D. Welsh, Denis G. Dyke
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Patent number: 4903708Abstract: A swab transport apparatus for storing and transporting to a laboratory a swab containing a sample or specimen such as a micro organism sample. The uncontaminated swab is pre-packaged within a sterile swab storage chamber of the apparatus from which it can conveniently be removed for taking a sample. Disposed proximate the swab storage chamber and in communication therewith, is a squeeze bulb to which a suitable transport medium can be added either at time of manufacture of the device, or shortly prior to use. Following addition of the transport medium the squeeze bulb and the return of the contaminated swab to the apparatus, the squeeze bulb is squeeze to cause the transport medium to flow, preferably via a circuitous path, into the swab storage chamber. The apparatus can then be forwarded to the laboratory for testing with the swab safely immersed within the appropriate transport medium. In an alternate form of the apparatus, a second squeeze bulb is provided.Type: GrantFiled: December 23, 1988Date of Patent: February 27, 1990Assignee: Saint-Amand Manufacturing Co., Inc.Inventor: Elmer F. Saint-Amand
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Patent number: 4886071Abstract: A system is provided for receiving, maintaining and processing blood samples for the subsequent separation and testing thereof. A pre-packaged blood sample receiving vessel is provided containing appropraite additives and a quantity of beads or other physical bodies for subsequent lysis, centrifugation, and separation of the sample. An additional pre-packaged arrangement is provided at the lab for the handling and removal of the lysed, centrifuged and separated sample in order to obtain the desired portion of the sample for appropriate laboratory testing procedures.Type: GrantFiled: March 2, 1987Date of Patent: December 12, 1989Assignee: Becton, Dickinson and CompanyInventors: Jack J. Mehl, Raymond T. Wasek, Jay Desai
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Patent number: 4877036Abstract: A swab transport apparatus for storing and transporting to a laboratory a swab containing a sample or specimen such as a micro organism sample. The uncontaminated swab is pre-packaged within a sterile swab storage chamber of the apparatus from which it can conveniently be removed for taking a sample. Disposed proximate the swab storage chamber and in communication therewith, is a squeeze bulb to which a suitable transport medium can be added either at time of manufacture of the device, or shortly prior to use. Following addition of the transport medium the squeeze bulb and the return of the contaminated swab to the apparatus, the squeeze bulb is squeezed to cause the transport medium to flow, preferably via a circuitous path, into the swab storage chamber. The apparatus can then be forwarded to the laboratory for testing with the swab safely immersed within the appropriate transport medium. In an alternate form of the apparatus, a second squeeze bulb is provided.Type: GrantFiled: November 28, 1988Date of Patent: October 31, 1989Inventor: Elmer F. Saint-Amand
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Patent number: 4874601Abstract: A kit for the direct and rapid preparation of radiolabelled compounds is disclosed comprising a Resin-S-Hg-R component where R is an organic group together with MZ* where M is an alkali metal and Z* is a radiohalogen isotope.Type: GrantFiled: June 14, 1988Date of Patent: October 17, 1989Assignee: Merck & Co., Inc.Inventor: Richard J. Flanagan
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Patent number: 4872561Abstract: A coordination complex comprising a radionuclide selected from the class consisting of radioactive isotopes of Tc, Ru, Co, Pt and Re and an isonitrile ligand of the formula:(CNX)R,where X is a lower alkyl group having 1 to 4 carbon atoms, wherein R is selected from the group consisting of COOR.sup.1 and CONR.sup.2 R.sup.3 where R.sup.1 can be H, a pharmaceutically acceptable cation, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms. R.sup.2, and R.sup.3 can be H, or a substituted or unsubstituted alkyl group having 1 to 4 carbon atoms, and R.sup.2 and R.sup.3 can be the same of different is disclosed. Kits that can be used to form these complexes are also disclosed.Type: GrantFiled: December 29, 1987Date of Patent: October 10, 1989Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard CollegeInventors: Alun G. Jones, Alan Davison, James Kronauge, Michael J. Abrams
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Patent number: 4867316Abstract: A prepared, self-contained slide culture kit system for the identification of fungi is presentd. The kit consists of a sterile two part, clear plastic container. In the container is a block of an appropriate agar medium. The agar block is one square centimeter. In the bottom of the container is affixed a piece of absorbent material. The absorbent material acts as a sponge when dampened and provides a moist atmosphere during incubation. Over the agar block is a sterile covering. Prior to inoculation the covering of the agar block is removed. The surface of the agar block is inoculated with the fungus being identified. A sterile cover slip is placed on the surface of the agar. The absorbent material is dampened with water, the cover of the container is replaced, and the kit is incubated at the required temperature. After incubation the cover slip is removed and examined microscopically.The Fungi Identification Kit eliminates the time consuming, and technically difficult procedures of current methods.Type: GrantFiled: May 2, 1988Date of Patent: September 19, 1989Inventors: William Rollender, Gordon Westermann
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Patent number: 4865988Abstract: A microbiological culture device which affords improved lapping over a surface to be tested comprises an elongated plate carrying a culture medium, a tubular case for the plate, and a stopper for the case made fast with one end of the plate and providing a handgrip for holding the plate, as well as an elastically deformable bridge formed on the plate the one end.Type: GrantFiled: May 16, 1988Date of Patent: September 12, 1989Inventor: Piergiacomo Guala
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Patent number: 4855326Abstract: A melt spinnable carrier agent such as sugar is combined with a medicament then converted into fiber form by melt spinning with "cotton candy" fabricating equipment. The as-spun product is converted to compacted individual dosage units. For certain medicaments a binding agent is added to the carrier agent. Examples are presented for oral administration, topical application, systemic and non-systemic, intravenous and intra-muscular infusion via multicameral containers. All applications utilize the extraordinarily rapid entry into solution upon contact with a solvent.Type: GrantFiled: March 18, 1988Date of Patent: August 8, 1989Assignee: Fuisz Pharmaceutical Ltd.Inventor: Richard C. Fuisz
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Patent number: 4839291Abstract: A disposable test pack for monitoring the efficacy of steam or ethylene oxide sterilization cycles includes a fiber board housing for a bioligical indicator. The housing includes an outer tube and a shorter inner tube. The outer tube has upper and lower portions which define a seam or gap at their adjoining open ends. The inner tube extends past the seam and telescopes into the upper and lower portions. The seam and the close tolerance between the inner tube and the upper and lower portions of the outer tube provide a tortuous path for the entry of sterilant into the interior of the housing. The tortuous path has a moisture absorbent surface and is dimensioned to promote intimate contact between the sterilant and the absorbent surface. The exterior of the housing can be lined with foil to prevent sterilant from permeating the housing, thereby preventing entry of the steam by any path other than through the seam.Type: GrantFiled: May 15, 1987Date of Patent: June 13, 1989Assignee: American Sterilizer CompanyInventors: Jon D. Welsh, Denis G. Dyke
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Patent number: 4830848Abstract: A physiologically acceptable solution of tantalum-178 having an activity of 0.1 to 200 millicuries per milliliter of tantalum-178 solution is provided. The solution is obtained from tungsten-178 bound to a column of an anion exchange resin which forms tantalum-178 in situ by eluting the column with a hydrochloric acid solution containing hydrogen peroxide to form an acidic solution of tantalum-178. The acidic solution of tantalum-178 then is neutralized.Type: GrantFiled: March 19, 1987Date of Patent: May 16, 1989Assignee: Massachusetts Institute of TechnologyInventors: Rudi D. Neirinckx, B. Leonard Holman, Michael A. Davis, Gale I. Harris
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Patent number: 4813432Abstract: A swab transport apparatus for storing and transporting to a laboratory a swab containing a sample or specimen such as a micro organism sample. The uncontaminated swab is pre-packaged within a sterile swab storage chamber of the apparatus from which it can conveniently be removed for taking a sample. Disposed proximate the swab storage chamber and in communication therewith, is a squeeze bulb to which a suitable transport medium can be added either at time of manufacture of the device, or shortly prior to use. Following addition of the transport medium the squeeze bulb and the return of the contaminated swab to the apparatus, the squeeze bulb is squeezed to cause the transport medium to flow, preferably via a circuitous path, into the swab storage chamber. The apparatus can then be forwarded to the laboratory for testing with the swab safely immersed within the appropriate transport medium. In an alternate form of the apparatus, a second squeeze bulb is provided.Type: GrantFiled: October 13, 1987Date of Patent: March 21, 1989Assignee: Saint-Amand Manufacturing, Inc.Inventor: Elmer F. Saint-Amand
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Patent number: 4803048Abstract: A laboratory kit is provided with a tear-off cover portion designed to fold into a compact package for containing and/or transporting a biological specimen or the like. The laboratory kit comprises a lower tray of vacuum-formed plastic or the like and containing selected laboratory implements such as a swab, glass slide, etc. A lightweight cover of paperboard or the like is affixed to and closes the tray. A tear-off portion of the cover is removable along perforated lines to open the tray and expose the implements therein for use, after which the tear-off portion is foldable along preformed score lines to form a compact package for containing a biological specimen or the like.Type: GrantFiled: April 2, 1987Date of Patent: February 7, 1989Inventor: Frederic L. Nason
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Patent number: 4789639Abstract: A liquid recovery device includes a receptacle, a swab for transferring a sample to a liquid in the receptacle, and a wringing unit to remove the liquid from the swab after the sample is transferred. The wringing unit has a sleeve with a closure in one end. A shaft of the swab extends through a passageway in the closure. When the swab in the receptacle is raised by upward movement of the shaft, an absorbent pad on the lower end of the shaft enters the passageway and is compressed. The compression of the pad wrings liquid therefrom which drips back into the receptacle. The device may be used in a method to prepare solutions of the sample in a minimum amount of liquid.Type: GrantFiled: January 2, 1987Date of Patent: December 6, 1988Assignee: Becton, Dickinson and CompanyInventor: Beverly M. Fleming
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Patent number: 4777964Abstract: A blood sampling kit having a plurality of glass vials for receiving blood therein; a puncture pin for puncturing the skin of the subject to be tested; an alcohol swab for cleansing the area to be punctured, and an envelope for returning the specimen to the laboratory. The specimen receiving kit further comprises a quantity of clay like material for sealing the ends of the blood vials after the blood sample has been received therein, so that blood is not lost during transit. The system provides that the test subject would receive the kit containing the above-referenced items to prick one finger, place blood into the plurality of blood-receiving vials, close off the end of the vials with a quantity of clay plug; return the vials to the kit, reseal the blood kit, noting the personal identification number, and placing the kit in an envelope provided for returning to the laboratory for testing.Type: GrantFiled: May 20, 1987Date of Patent: October 18, 1988Inventors: David Briggs, Kent A. Leger, Brenda Briggs
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Patent number: 4768653Abstract: A urine specimen maintenance formulation is provided which, when the urine specimen is added, maintains the specimen in the desired unaltered form for subsequent testing, without the need for refrigeration or other preservation measures, while simultaneously preventing any additional bacterial growth in the specimen. The formula of the invention includes distilled water, mannitol, boric acid and sodium borate. Additionally, the formula may include a buffer, such as sodium acetate, glutamine or other amino acids, and a surface active or dispersing agent to facilitate concentration of cellular elements during subsequent centrifugation of the sample for microscopic examination, as well as to facilitate preservation of organisms.Type: GrantFiled: December 29, 1987Date of Patent: September 6, 1988Assignee: Becton, Dickinson and CompanyInventors: Jayraj S. Desai, Jack J. Mehl
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Patent number: 4765468Abstract: A field security package for a dosimeter includes two interlocking rigid elements made of a reflective polyvinyl chloride material in which a dosimeter is positioned. The elements collectively providing a spiral wound grid surface to provide adequate ventilation, simultaneously a cover to prevent ingress of moisture, a reflective surface for heat and a radiation pervious material. The two elements of the security package can be interlocked together with the link of a chain for secure mounting from support means.Type: GrantFiled: April 26, 1985Date of Patent: August 23, 1988Inventor: Barry D. Graham
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Patent number: 4761379Abstract: A biological specimen collection device comprises a specimen receptacle having a closed first end and an open second end. A removable conduit is provided for introducing a biological specimen into the receptacle and is connected to the second end of the receptacle. A base removably receives the first end of the receptacle and supports the receptacle in a substantially vertical position. A cap is removably connected to the base, this cap adapted to provide a liquid seal between the cap and the open second end of the receptacle. The cap is maintained in a protective environment during introduction of the biological specimen into the receptacle. Access is permitted to the cap after the specimen has been collected for subsequently capping the open end of the receptacle with its contents.Type: GrantFiled: August 9, 1984Date of Patent: August 2, 1988Assignee: Becton, Dickinson and CompanyInventors: Edward L. Williams, Larry A. Franchore
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Patent number: 4741437Abstract: The application discloses a test vial including a test article for immersion into a fluid medium, a sealed chamber which contains the fluid medium, and an open chamber which is external to the sealed chamber and which supports the test article. The sealed and open chambers define a barrier which isolates the fluid medium from the test article. The open chamber is covered by a closure. Retaining means are positioned on the closure and cooperatively support the closure in a first position and cooperatively receive the closure in a second position. The closure has a means for penetrating the barrier and for injecting the test article into the fluid medium when the closure is moved from the first position to the second position while maintaining the sealed chamber in a sealed condition upon movement of the closure from the first position to the second position.Type: GrantFiled: June 24, 1985Date of Patent: May 3, 1988Assignee: North American Science Associates Inc.Inventors: Theodore W. Gorski, Richard F. Wallin
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Patent number: 4739881Abstract: A quick open syringe for use in testing an ethylene oxide sterilizer comprises a vented hollow container for receiving and holding a test unit therein. A lid with a handle covers an opening to the container and the container itself is formed with a piercing point. The quick open syringe and enclosed test unit can be positioned in a sterilizable peel pouch. After completion of a sterilization cycle, the container and lid handle may be grasped to remove the lid from the container and puncture the peel pouch with the point to enable removal of the test unit from the quick open syringe and the pouch.Type: GrantFiled: August 14, 1986Date of Patent: April 26, 1988Assignee: Beckton, Dickinson and CompanyInventor: Loran H. Bruso
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Patent number: 4732850Abstract: A biological indicator is made of a vial which contains a "spore dot", a nutrient solution in a frangible ampoule, and means for positioning the spore dot and for breaking the ampoule to release the nutrient solution when the cap of the vial is fully pressed on. The nutrient solution typically contains a pH indicator to determine whether all active spores on the strip were killed by a sterilization process which takes place prior to breaking the ampoule.Type: GrantFiled: July 5, 1985Date of Patent: March 22, 1988Assignee: E. R. Squibb & Sons, Inc.Inventors: James R. Brown, Steven T. Buglino
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Patent number: 4720017Abstract: An improvement in specimen kits that reduces significantly the possibility of contamination of the specimen by either user or container; of the patient by the swab used to obtain the specimen; and of a subsequent handler of the container by the specimen. It permits the collected specimen to be transported to the diagnostic processing laboratory in common, widely used medical specimen mailing containers, while permitting the use of swab lengths that are appropriate to the type of specimen desired. The improvement is made possible by a unique double-ended stopper that maintains the specimen container sterile until use, then acts as a cap for engaging the swab shaft for withdrawal while maintaining a tight and sterile shipping container after the specimen is taken and while it is subsequently handled.Type: GrantFiled: July 27, 1982Date of Patent: January 19, 1988Assignee: Medical Media Laboratory, Inc.Inventor: Cornelius N. Pestes
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Patent number: 4717018Abstract: A unitary snap hinge made of plastic with two hinge parts which are connected with each other by means of a main joint. A flexible connecting piece is connected with the hinge parts by means of secondary joints, whereby the secondary joints have a distance from the main joint transverse to the joint axis and that the joints are designed as film joints. The hinge parts have the tendency to snap into the one or other end position from a position of an unsteady balance within their own pivot range. The snap hinge is a separate structural element. The one hinge part supports a locking element for a removal opening, the other hinge part supports at least one adapter piece with arresting elements. Thereby, the snap hinge can be mounted on a container or on the locking piece of the same.Type: GrantFiled: July 28, 1986Date of Patent: January 5, 1988Assignee: Boehringer Mannheim GmbHInventors: Klaus D. Sacherer, Erich Weiss, Jochen Koehn, Ulrich Brach
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Patent number: 4675299Abstract: A self-contained reagent package device for an assay comprises a support member and a plurality of wells in the support member. All of the wells are capable of retaining liquids therein. At least one of the wells has an aperture at its bottom end for the passage of liquids therethrough. The one well includes a carrier to which a reagent is bound and further includes a porous filter positioned between the carrier and the aperture which is capable of retaining liquids used in the assay under normal atmospheric pressure conditions. The filter permits the passage of those liquids, including unbound and soluble substances, at increased pressure within the one well. Further, the filter is capable of retaining the carrier and substances bound thereto. At least one of the wells includes a predetermined amount of reagent therein. Another of the wells is empty so that the specimen to be assayed may be deposited therein.Type: GrantFiled: December 12, 1984Date of Patent: June 23, 1987Assignee: Becton, Dickinson and CompanyInventors: Thomas R. Witty, Robert E. Curry, Roger E. Smith
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Patent number: 4666833Abstract: A process for the production of a diagnostic device which is envisaged, in particular, for the detection of a pathologically increased concentration of dehydrogenases in fluids of humans, animals or plants and consists of a carrier and a substance mixture, in which, in each case with exclusion of UV radiation, the substance mixture, which has been adjusted to a pH value in the acid range, is brought into contact, in liquid form, with the carrier and the combination of carrier and substance mixture is subsequently dried and then enclosed in a packaging casing which is opaque to light of higher energy than red light. The process has the peculiarity that the dried combination of carrier and substance mixture in the packaging casing is securely sealed against entry of air and moisture. The device thus produced can be stored for a long time before use, without its ability to function being substantially changed.Type: GrantFiled: August 15, 1983Date of Patent: May 19, 1987Assignee: Medi-Pharma Vertriebsgesellschaft mbHInventors: Asok K. Roy, Roland W. Steinbach
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Patent number: 4657869Abstract: A device is disclosed into which a test solution can be added and at least the first step of a specific binding assay can be carried out. The device comprises a two compartment tube containing a removable rod having at one end a plurality of filaments coated with a specific binding partner for the analyte to be determined.Type: GrantFiled: May 18, 1984Date of Patent: April 14, 1987Assignee: E. I. Du Pont de Nemours and CompanyInventors: James C. Richards, Robert B. Taylor
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Patent number: 4636477Abstract: A procedure for loading into an instrument cuvettes intended for chemical analysis and/or handling of liquids, said cuvettes being loaded into the instrument directly from the shipping package, and a cuvette package. The cuvette package includes a box portion for supporting the cuvettes having an open feeding end, and a cover portion detachable from the box portion and provided with a depending pushing member. When the cover portion is disposed contiguously atop the box portion to form the package, the pushing member closes the feeding end to securely contain any cuvettes therein. When the cover portion is detached from the box portion, dust-free and scratch-free transfer of cuvettes into the instrument while the package is attached to an input aperture of the instrument may be accomplished by pushing, from behind, the rows of cuvettes in the package with the pushing member of the cover portion.Type: GrantFiled: December 28, 1984Date of Patent: January 13, 1987Assignee: Kone OyInventors: Pekka Ronka, Raimo Vaintola
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Patent number: 4637061Abstract: A specimen, sample collection and transport container comprising a flexible plastic bag which is separated into selectively sealed chambers by leak-proof interlocking, multiple track, reclosable fasteners. The bag comprises a sheet of coextruded polyethylene-Saran-polyethelene material which is folded in half and sealed at the side edges. An interior fastener substantially traverses the container parallel to the folded bottom, thereby defining a lower chamber. An entrance fastener is affixed to the upper edges to selectively seal the entrance. Gripper flaps are added to the exterior of the container to facilitate the opening of the interior fastener. The lower chamber is supplied with a fixative or transport solution which is introduced by clipping or puncturing the lower corner or edge of the bag. The corner or hole is then sealed.Type: GrantFiled: December 20, 1985Date of Patent: January 13, 1987Inventor: J. Richard Riese
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Patent number: 4608231Abstract: A self-contained reagent package device for an assay comprises a support member and a plurality of wells in the support member. All of the wells are capable of retaining liquids therein. One of the wells has on its interior surfaces an immunoreactive substance for carrying out the assay. At least one of the wells includes a predetermined amount of reagent therein. Another of the wells is empty so that the specimen to be assayed may be deposited therein. A protective cover is sealed over the open ends of the wells to maintain the incorporated reagents in stable form prior to use. The cover preferably does not seal the open end of one of the wells which serves as a specimen collecting well.Type: GrantFiled: June 3, 1985Date of Patent: August 26, 1986Assignee: Becton, Dickinson and CompanyInventors: Thomas R. Witty, Robert E. Curry, Roger E. Smith
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Patent number: 4589548Abstract: An apparatus for collecting sputum including: a sputum container having an open end and a closed end; and a funnel which includes a mouth at one end and a discharge portion at the other end. The discharge portion is removably attachable to the container to establish fluid communication between the funnel and the container. A cap is provided for removably covering the container opening. Further provided is a base having a top which includes a recess for receiving the closed end of the container to support at least a portion of the container above the base and a chamber with an opening at its lower end. The cap is releasably held within the chamber with the inside of the cap facing the opening.Type: GrantFiled: December 6, 1984Date of Patent: May 20, 1986Assignee: Biomedical Polymers, Inc.Inventor: John E. Fay
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Patent number: 4582699Abstract: A method for rapid diagnosis of gonorrhea is set forth comprising assay of the enzyme immunoglobulin A protease (IgAP). Immunoassays including radioimmunoassay and enzyme-linked immunoassay with monoclonal antibodies to IgAP are disclosed. A kit for early detection of gonorrhea is given. The assay and kit of the present invention may also be used in the detection of meningitis.Type: GrantFiled: December 23, 1981Date of Patent: April 15, 1986Assignee: Magbon Test CompanyInventor: Kittie A. Murray
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Patent number: 4580682Abstract: The application discloses a test vial including a test article for immersion into a fluid medium, a sealed chamber which contains the fluid medium, and an open chamber which is external to the sealed chamber and which supports the test article. The sealed and open chambers define a barrier which isolates the fluid medium from the test article. The open chamber is covered by a closure. Retaining means are positioned on the open chamber and on the closure. The retaining means cooperatively support the closure in a first position and cooperatively receive the closure in a second position. The closure has a means for detaching the barrier from the open and sealed chambers and for injecting the test article in the fluid medium when the closure is moved from the first position to the second position.Type: GrantFiled: January 31, 1983Date of Patent: April 8, 1986Assignee: North American Science Associates, Inc.Inventors: Theodore W. Gorski, Richard F. Wallin
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Patent number: 4562159Abstract: A method and test kit are disclosed for detecting the presence of hepatitis B virus in a test specimen containing at least a portion of the DNA of the virus. A test reagent comprises cloned hepatitis B virus-DNA that has been repurified by treatment with a restriction enzyme and labelled to high specific activity with a radioactive label. The sample to be tested is fixed to a solid matrix, incubated in the presence of the test reagent under hybridization conditions and detected by hybridization to the labelled DNA probe. The uncombined HBV-DNA (labelled) is removed from the substrate, and the hybridized HBV-DNA determined by scintillation counting or by autoradiography of the substrate.Type: GrantFiled: March 31, 1981Date of Patent: December 31, 1985Assignee: Albert Einstein College of Medicine, A Division of Yeshiva Univ.Inventor: David A. Shafritz
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Patent number: 4549655Abstract: A container for a layered chemical analysis system includes a first, rigid, member and a second, flexible, member. The flexible member is moveable with respect to the rigid member from a first, unstressed, position to a second, stressed, position in which the flexible member is flexed to generate a reaction force acting in a direction substantially normal to stacked layers to thereby urge the same into intimate contact with each other.Type: GrantFiled: December 5, 1983Date of Patent: October 29, 1985Assignee: E. I. Du Pont de Nemours and CompanyInventors: Jesse G. Forsythe, Jr., Sally S. Stafford
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Patent number: 4522922Abstract: Ligand having at least two determinant or binding sites is contacted with a labeled first binder, an unlabeled second binder different than the first binder and a precipitating binder specific for the second binder, with such contacting precipitating a complex of the ligand and the first and second binders to thereby separate bound labeled binder from unbound labeled binder. The bound and/or unbound labeled binder is determined as a measure of the ligand.Type: GrantFiled: April 16, 1982Date of Patent: June 11, 1985Inventors: Jose Carro, Frank de Velasco
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Patent number: 4485086Abstract: A novel chemical method of labeling porphyrin compounds, specifically hematoporphyrin derivative (HPD), with the radionuclide .sup.111 In or .sup.113m In producing a radioactive tracer material suitable for biomedical applications. HPD labeled with .sup.111 In or .sup.113m In is biologically active in vivo and is preferentially taken up by tumors. This provides a simple and specific means of localizing and detecting neoplasms in man or in animal by scintigraphic imaging techniques.Type: GrantFiled: April 11, 1983Date of Patent: November 27, 1984Inventor: Dennis W. Wong
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Patent number: 4472371Abstract: Antibodies to human carcinoembryonic antigen (CEA), human alphafetoprotein (AFP) and/or to other anti-human tumor associated antigens (TAA) labeled with technetium-99m (Tc-99m) are administered to a human after the human has been administered anti-CEA, anti-AFP and/or other anti-TAAs, such as human melanoma-associated antigen, human neuroblastoma-associated antigen, human breast cancer-associated antigen, human ovary-associated antigen, human sarcoma-associated antigen, etc. The biodistribution of the labeled product composition accumulates at cancer sites, e.g., tumors that produce or express TAA, due to the affinity that the antibody has for the given tumor antigen. The accumulation at the tumor site(s) of a suitable amount of Tc-99m associated with the antibody allows detection via external scintigraphy and other means. Detection of the Tc-99m antibody composition by external scintigraphy permits localization and detection of tumors in vivo via a semi-noninvasive technique.Type: GrantFiled: January 6, 1982Date of Patent: September 18, 1984Assignees: Summa Medical Corporation, University Patents Inc.Inventors: Scott W. Burchiel, Buck A. Rhodes, David R. Crockford
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Patent number: 4464552Abstract: A dispensing package for diabetic test care strips of paper includes a paperboard pouch containing a test strip unit. The pouch has a reclosable flap affording access to the contained test strip unit, the latter comprising a paperboard backing panel having a tab on one end accessible at the opening of the pouch. Attached to the other end of the panel is the edge portion of a stack of test strip material having parallel cuts extending from the free edge of the stack toward the attached edge, and which cuts define test strips adapted to be torn from the unit after it is removed partially or entirely from the pouch.Type: GrantFiled: October 29, 1981Date of Patent: August 7, 1984Assignee: James River-Dixie/Northern, Inc.Inventor: Thomas D. Pawlowski
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Patent number: 4446970Abstract: An improved diabetic set in the form of a pressure resistant case for containing at least one insulin bottle, a syringe and, optionally, a supply of alcohol cloths or similar accessories for sterilization. The case includes a container and a lid that preferably telescopically encloses the container in the manner of a cap. The container includes means for releasably securing the insulin bottle and syringe in such a manner as to facilitate hygienic administration of insulin under all conditions.Type: GrantFiled: July 21, 1981Date of Patent: May 8, 1984Inventor: Gunter Further
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Patent number: 4427112Abstract: Interior by-pass for underground gas service line is installed from building basement without need for excavation, and has a tightenable adapter attached on each end of the by-pass tubing to connect and seal the tubing to the interior periphery of the service line. Each adapter provides a pair of spaced-apart expanded sealing gaskets between the tubing and the service line, and a gas-leakage passage extending from the interior of the tubular adapter to the exterior spacing between the adapter gasket pair. Temporary gas-tight plugs are provided at respective locations between each leakage passage and the adjacent end of the by-pass tubing, and compressed natural gas test-pressure is applied within the tubing. Via both of the referred to leakage passages, the test pressure is exerted against all of the gasket seals to confirm gas-tightness thereof.Type: GrantFiled: September 24, 1982Date of Patent: January 24, 1984Inventors: Bernard A. Di Giovanni, Francisco J. Ciminiello
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Patent number: 4387804Abstract: A package for containing a preselected amount of a product in the form of a pill or the like is adapted to be converted for use as a cup for containing liquid and includes a pair of sidewalls made of paperboard which are joined together along three mutual edges thereof, the fourth mutual edges defining the top of the cup. A support flap is connected by a perforated score line along an edge of one of the sidewalls at the top of the cup and has a plastic blister bonded to one face thereof within which a pill or other product may be contained. The support flap is provided with an aperture therein registering with the interior of the blister and a frangible closure, preferably a metal foil, is secured in overlapping relationship to the aperture to prevent loss of the product prior to the time of use. Spaced fold lines in the sidewalls allow folding of the package to a compact condition for storage, and the support flap may be torn away from the top of the cup during use to allow ready access to the product.Type: GrantFiled: February 8, 1982Date of Patent: June 14, 1983Assignee: Champion International CorporationInventor: John J. Austin
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Patent number: 4366320Abstract: A novel reagent useful for preparing adducts of diene so that the diene may be assayed by gas liquid chromatography utilizing an electron capture detection system.Type: GrantFiled: July 31, 1980Date of Patent: December 28, 1982Assignee: The Upjohn CompanyInventor: Terry J. Gilbertson
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Patent number: 4336880Abstract: A liquid urine preservative comprised of boric acid and alkali formate dissolved in a bacteriostatic liquid, such as water or glycerine. The preservative may be included in an evacuated container for a urine sample to facilitate taking of correct sample amounts.Type: GrantFiled: November 24, 1980Date of Patent: June 29, 1982Assignee: Becton, Dickinson and CompanyInventor: Jack J. Mehl
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Patent number: 4311792Abstract: A culture collecting swabbing tip is carried on one end portion of a small diameter flexible wire which enables the tip to reach into a curved and narrow body passage. A sleeve-type handle is telescoped slidably onto the other end portion of the wire and enables the effective length of the wire to be adjusted so that the wire can fit into an outer transport tube but can be effectively lengthened to reach into a long body passage. The transport tube contains a glass ampoule which may be broken to moisten the swabbing tip with a culture-sustaining transport media after a culture has been collected on the tip.Type: GrantFiled: April 14, 1980Date of Patent: January 19, 1982Assignee: Marion Health and Safety, Inc.Inventor: Carl F. Avery
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Patent number: 4240547Abstract: A compact, reusable specimen mailer for safely shipping fragile specimen containers via the postal service. Two substantially identical L-shaped matable parts are each provided with a long leg having a flat free end and a flat inside face, and a short leg having a flat inside face, so that the two parts may be joined together with the free end of the long leg flush against the inside face of the short leg and the inside faces of the long legs of the two parts flush against each other. Typically, the long leg of each part forms apertures for receiving test tubes and the inside face of the short leg of each part forms a cavity for receiving the ends of the test tubes, which protrude from the free end of the long leg of the other part. Also typically, the long leg forms an aperture opening out of its free end and its inside face, and connected with another cavity formed in the inside face of the short leg, for receiving a slide holder.Type: GrantFiled: November 27, 1978Date of Patent: December 23, 1980Inventor: Billy W. Taylor
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Patent number: 4231923Abstract: The present invention provides an assay method for opioid activity comprising the steps of:(a) incubating together an opiate receptor material, a radio-iodinated structural analogue of leucine-enkephalin or methionine-enkephalin, and a liquid sample;(b) measuring the percentage inhibition of the binding of the radio-iodinated compound to the opiate receptor material; and(c) determining the opioid activity of the liquid sample using the percentage inhibition measurement.Also provided are a test kit of value in the performance of such assays, and novel compounds of use in such assays together with methods for their preparation.Type: GrantFiled: October 13, 1977Date of Patent: November 4, 1980Assignee: Burroughs Wellcome Co.Inventors: Richard J. Miller, Kwen-Jen Chang, Pedro Cuatrecasas
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Patent number: 4221295Abstract: A package and device for collecting urine wherein the parts comprising the device are packaged so that they are removed in the order that they are used and are maintained in a sterile condition prior to use.The device includes instructions, cleansing means, a container, funnel assembly, a cap for the container and an identification label packaged in such a manner so as to be sterile before use and removed aseptically in the order that such parts are used.Type: GrantFiled: January 12, 1979Date of Patent: September 9, 1980Inventors: Steve Tuchband, John Uhoch, Jr.
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Patent number: 4211530Abstract: A diagnostic method and test-kits for the demonstration and determination of the lipoprotein LP-X in serum by removal of interfering lipoproteins, precipitation of LP-X in the remaining serum and measuring the LP-X content in the suspension, obtained by photo-optical or visual methods.Type: GrantFiled: February 8, 1978Date of Patent: July 8, 1980Assignee: Akzo N.V.Inventors: Bastiaan C. Goverde, Peter S. L. Janssen, Gerhard M. Kostner
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Patent number: RE32417Abstract: Antibodies to human carcinoembryonic antigen (CEA), human alphafetoprotein (AFP) and/or to other anti-human tumor associated antigens (TAA) labeled with technetium-99m (Tc-99m) are administered to a human after the human has been administered anti-CEA, anti-AFP and/or other anti-TAAs, such as human melanoma-associated antigen, human neuroblastoma-associated antigen, human breast cancer-associated antigen, human ovary-associated antigen, human sarcoma-associated antigen, etc. The biodistribution of the labeled product composition accumulates at cancer sites, e.g., tumors that produce or express TAA, due to the affinity that the antibody has for the given tumor antigen. The accumulation at the tumor site(s) of a suitable amount of Tc-99m associated with the antibody allows detection via external scintigraphy and other means. Detection of the Tc-99m antibody composition by external scintigraphy permits localization and detection of tumors in vivo via a semi-noninvasive technique.Type: GrantFiled: February 3, 1986Date of Patent: May 12, 1987Assignees: Summa Medical Corporation, University Patents Inc.Inventors: Scott W. Burchiel, Buck A. Rhodes, David R. Crockford