Abstract: A urinary catheter assembly includes a first outer package having a first material, a second inner package contained inside of the first outer package, and an intermediate cavity defined as an area inside the first outer package and outside the second inner package. The first material has a first water vapour transmission rate (WVTR) measured according to ASTM F1249 at 90% relative humidity (RH) and 38° C. between 1 g/(m2·24 h) and 6 g/(m2·24 h). The second inner package has a second material having a second WVTR measured according to test method A at 65% RH and 30° C. below 3 g/(m2·24 h). The second inner package contains a swelling medium and an intermittent urinary catheter with a hydrophilic coating.

Abstract: Trays and packaging systems for a prosthesis delivery device that permit conversion from a packaged, storage/or shipping configuration to a loading configuration for the loading of a prosthesis. The prosthesis may be a prosthetic heart valve. In the packaged configuration, the delivery device can be supported within the tray, which includes a recess and at least one clip maintaining the delivery device within the recess. In the loading configuration, the delivery device can be arranged for loading of the prosthesis within a bath area of the tray. Optionally, the delivery device can be stored in the packaged configuration in a U-shape. Some embodiments include an additional recess for positioning an indeflator fluid line or tubing. Methods of use are also disclosed.

Abstract: The present invention relates to a syringe and medical kit, which allow for doses of epinephrine of 0.15 mg or 0.15 mL, 0.3 mg or 0.3 mL, and 0.5 mg or 0.5 mL, the most commonly prescribed doses which are utilized today in treating anaphylaxis or other allergic reactions. Currently, existing syringes may include many markings of ten or more dosages. Although these prior art syringes are useful, it is difficult to use them for a patient who must quickly identify a correct dose level among many other marks. The above problem can be addressed by a syringe design which has only a few dosage markings, which correspond to commonly used standard dosages for children and adults. When used with a standard concentration of 1:1000 epinephrine solution, such a device can rapidly provide a known quantity of medicine to a patient who is in urgent need of it.

Abstract: A surgical apparatus comprises an instrument shaft having a proximal end and a distal end, an end effector coupled to the distal end of the shaft, and a sheath disposed on an external surface of the instrument shaft. The sheath has a first section made of ePTFE and a second section made of a second material, wherein the second section provides a friction seal with the shaft, and wherein the ePTFE is gas-permeable.

Abstract: A terminally sterilized medical procedure kit includes a recovered item and a new item packaged together as a single stock keeping unit. A method for processing at least a portion of a first medical procedure kit includes the steps of receiving a recoverable item of the first kit, performing a processing operation on the recoverable item, providing a new item, combining the recoverable item and the new item in a second kit, and terminally sterilizing the second kit. A method for recovering at least a portion of a terminally sterilized medical procedure kit includes the steps of purchasing a recoverable item of the first kit from an owner and receiving the recoverable item by the purchaser.

Abstract: Device containers, such as therapeutic kit containers, are disclosed. In one embodiment, a device container includes a first member configured to releasably hold a syringe barrel, a second member configured to releasably hold a vial, wherein the second member is coupled to the first member by a first hinge, and a third member configured to releasably hold a vial adapter, wherein the third member is coupled to the second member by a second hinge.

Abstract: A catheter assembly package includes a hydrating sleeve and a catheter disposed in the hydrating sleeve, the hydrating sleeve and the catheter enclosed in a sealed package. A coating can be disposed on an outer surface of the catheter and in contact with an inner surface of the hydrating sleeve. The hydrating sleeve can include a fluid and an outer foil layer, and the fluid can be confined to the hydrating sleeve. The sealed package can enclose the hydrating sleeve in a first compartment and the catheter in a second compartment.

Abstract: A tray (100) for accommodating a coiled medical device, such as a catheter assembly (700), includes a first compartment (101), a second compartment (102), and a third compartment (103). The catheter assembly (700) and devices associated with a catheterization procedure, such as syringes (701,702) containing sterile water and lubricating jelly and a specimen container (703) can be disposed within the tray. Printed instructions (1001) can be included with the tray (100). One or more layers of wrap material (2200) can be folded about the tray (100) to enclose the tray (100) and other items, such as an additional layer of wrap material (2701), packaged liquid hand sanitizer (2401), and packaged gloves (2402). When a health care services provider (3101) unfolds the wrap material, the same can be used to create a sterile field beneath a patient (3201).

Abstract: This invention relates to a tip protector for an instrument such as an endoscope or borescope.

Abstract: An apparatus includes a container, a needle, and an actuation assembly. The container contains a dose of a naloxone composition having a delivered volume of at least about 0.34 mL. The actuation assembly includes an energy storage member that produces a force on a movable member to move the needle and to deliver the dose of the naloxone composition. The 90% confidence interval of at least one of the relative mean maximum naloxone plasma concentration after dose delivery into the body (Cmax), time to reach the maximum naloxone plasma concentration (Tmax), area under the plasma concentration-time curve from pre-dose (time 0) extrapolated to infinity (AUC0-?), or area under the plasma concentration-time curve from pre-dose (time 0) to the time of the last quantifiable concentration (Tlast) (AUC0-t) of the delivered dose to a delivered dose of a corresponding naloxone composition delivered via a manually-actuated syringe is within 80% to 125%.

Abstract: A custom procedure kit is provided, which comprises a plurality of medical-procedure tools and a cover that is wrapped around the plurality of medical-procedure tools to form wrapped tools. An outer container is fully disposed about the wrapped tools, and at least one sheet is disposed between the outer container and the wrapped tools. The sheet includes a listing of the plurality of medical-procedure tools and, for at least some of the medical-procedure tools, an unselected end-user selectable field.

Abstract: An insulated, epinephrine auto-injector case that also includes a rapid-opening cap, two spring-loaded chambers, each with a rapid-opening cap to facilitate immediate and easy availability of the auto-injector for grasping by the user.

Abstract: An arrow device having a frangible reservoir for dispensing lubricants and/or tracking material, and an arrow comprising a lubricant or tracking material is described. A frangible reservoir may have an enclosure comprising frangible material that can be ripped, punctured, torn, burst or otherwise compromised to release the contents therein. A frangible reservoir may be configured as part of an arrow shaft, arrowhead, or a dispensing device and may include a cavity therein. A frangible seal may be configured over a portion of the reservoir, such as a release port. A frangible reservoir may be configured to rupture when the arrow that it is attached to is shot from a bow, or enters an object. A rupture element may be configured with a frangible reservoir or dispensing device to rupture or open the frangible reservoir.

Abstract: This document relates to methods and materials for reducing the risk of infection after a shoulder surgery or medical procedure. For example, this document relates to methods and materials for using a topical composition containing clindamycin or erythromycin to reduce the risk of or to prevent infection associated with shoulder surgeries or medical procedures.

Abstract: A stent cover for enclosing a compressible stent during a stent crimping process, the stent cover having an outer sheath with a proximal end, a distal end, an end portion at the distal end of the sheath having a first diameter, and a stent-retaining portion adjacent to the end portion and having an uncompressed diameter that is larger than the first diameter of the end portion for retaining a stent in its uncompressed condition.

Abstract: Medical devices, medical procedure trays, kits and related methods are provided for use to perform medical procedures that require access to the interior of a bone. The devices, trays and methods allow multiple use of non-sterile medical devices with sterile medical devices for performing medical procedures requiring sterile conditions.

Abstract: A package system and method are provided for storing and shipping of elongated endoluminal devices. In one aspect, the system includes a packaging tray having a first area to maintain the position of a first portion of the elongated endoluminal device and a second portion retaining an opposing portion of the elongate device. The second portion configured to hold the coupling element of the assembly and being radially spaced outward from the first portion.

Abstract: Medicine storage arrangement methods of assembly and use are described. The arrangements include a multi-chamber pill dispensing arrangement; and, a holder arrangement for an alternate medical dispenser, such a medicine dispensing pen or a syringe. Methods of assembly and use are described.

Abstract: A catheter product package and method of forming same in which the package comprises a sheet material wrapped about the catheter product to form a package for the catheter product. The catheter product extends generally longitudinally within the package, and the sheet material extends from a point beyond the proximal end to a point beyond the distal end of the catheter product. The sheet material of the package is wrapped about the catheter product in a mariner defining confronting proximal end edges, confronting distal end edges, and confronting side edges. The confronting proximal end edges, distal end edges and side edges of the sheet material are joined by a seal after the sheet material is wrapped about the catheter product to define a sealed cavity. The sheet material has a tear strip affixed to it which causes the sheet material to tear along the tear strip to thereby cause the package to open along an intended opening line.

Abstract: The present disclosure relates to methods of treating a patient suffering from or at risk of developing an ocular disease, disorder or injury, and includes treatment regimens using a double-stranded RNA compound that down-regulates CASP2 expression, or a pharmaceutically acceptable salt thereof.

Abstract: Uses of BMP-1 isoforms for diagnosing and treating defects and disorders of bone and soft tissues are described. Also described is a newly isolated variant of the BMP-1 isoform BMP-1-3.

Abstract: The sterilizing tool is configured to wipe debris from and to sterilize and/or dry a working end-site of medical device; using a wiping, twisting, dabbing, push/pull, and/or screwing motion around all of the surface aspects of the device to be sterilized. Additionally, the sterilizing tool is configured to form fit to the surfaces of the end-site and to apply an inclusive layer of an anti-pathogenic agent to the inner and outer surfaces of the working end-site. The sterilizing tool may be frictionally engaged with and retained on the working end-site until removed and the end-site is ready for use. The sterilizing tool is intended for a one time, single use, disposable application.

Abstract: A method for administering a polymeric-based delivery system to a subject is described. The method comprises contacting a housing comprising a polymer-based delivery system with a heat-generating component for a period of time; and injecting the delivery system into the subject.

Abstract: Compositions are disclosed containing a polymeric mixture diluted into an aqueous solution, which can be usefully applied to any surface mat is hydbcphoixc to act, for example, as an aotifoggiag coating with minimal optical distortion and excellent transparency. The compositions can also be used as lubricious agents on medical implants, shunts, and surgical supplies to minimize tissue trauma, to maximize bio-compatibility, and to increase healing by enhancing better irrigation and flow in adjacent tissue.

Abstract: A package for a multi-component medical device is disclosed. The package includes a bottom portion with cavities providing individual access to different components of the medical device, thereby enabling a user to remove components from the package in any order without disturbing the remaining component or components. The package also includes a barrier affixed to the bottom portion for sealing the package.

Abstract: The present invention relates to systems and methods for preparing and completing surgical and medical procedures. In particular, the invention relates to kits for improving preparation and completion time for a medical or surgical procedure in which the kit includes modularized compartments containing sterilized medical or surgical equipment and wherein the medical or surgical equipment is organized and/or ordered within the kit to generally correspond to the sequence of steps of the medical or surgical procedure. The kit is particularly applicable to recanalization procedures for stroke patients as well as revascularization procedures for acute myocardial infarction patients where a kit enables faster preparation and completion of these procedures.

Abstract: Needle mail-back systems and kits are disclosed. Methods of making and using needle mail-back kits are also disclosed. Methods of doing business involving needle mail-back systems and kits are also disclosed.

Abstract: A tray (100) for accommodating a coiled medical device, such as a catheter assembly (700), includes a first compartment (101), a second compartment (102), and a third compartment (103). The catheter assembly (700) and devices associated with a catheterization procedure, such as syringes (701,702) containing sterile water and lubricating jelly and a specimen container (703) can be disposed within the tray. A first barrier (105) and second barrier (106) separate the compartments. The barriers can have openings (121,122) therein to accommodate large syringes or to enable the first compartment (101) to be used as a lubricant applicator for the catheter. The first compartment (101) can include a stair-stepped contour (115) such that the syringes are held at different depths to facilitate ease of use. The various devices can be disposed within the tray (100) in accordance with their order of use in the catheterization procedure.

Abstract: A multiple medicament container and method for retaining a plurality of medicaments for students on excursions from school is disclosed. The container is configured to securely hold medicaments of a variety of configurations including epinephrine pens and asthma inhalers as well as other forms. The container also holds cards identifying medical conditions relating to each student for which medicaments are provided as well as cards denoting administration protocols for each medicament loaded into the container. A single medicament embodiment of the container is also disclosed wherein the container is already paired to the subject student.

Abstract: A tray (100) for accommodating a coiled medical device, such as a catheter assembly (700), includes a first compartment (101), a second compartment (102), and a third compartment (103). The catheter assembly (700) and devices associated with a catheterization procedure, such as syringes (701,702) containing sterile water and lubricating jelly and a specimen container (703) can be disposed within the tray. Printed instructions (1001) can be included with the tray (100). One or more layers of wrap material (2200) can be folded about the tray (100) to enclose the tray (100) and other items, such as an additional layer of wrap material (2701), packaged liquid hand sanitizer (2401), and packaged gloves (2402). When a health care services provider (3101) unfolds the wrap material, the same can be used to create a sterile field beneath a patient (3201).

Abstract: Different length and diameter size catheters may be packaged in a universal catheter tray assembly that utilizes identical base trays. Catheter size selectors, which include a size indicia formed therein, are snap connected to the base tray and define at least a portion of a catheter capture channel with an opening width corresponding to the size indicia. The universal catheter tray assembly is configured for packaging a catheter with a size corresponding to the size indicia and with any one of a plurality of tip shapes such that first and second segments of the catheter are confined in first and second catheter capture channels, respectively.

Abstract: The carrier for prefilled syringes has a body made from a dimensionally stable elastic material with a chamber for inserting the syringe. The flange of the syringe cylinder is fixed in the axial direction in a defined recess, whereas the syringe plunger is fixed in any position in an elongated recess.

Abstract: The system according to the present disclosure includes a metal stent (3) as a medical implant for treating lesions in blood vessels and a packaging (1) having an inside volume, in which the stent (3) is arranged in a protected manner. The stent (3) has a plurality of webs (33), which produce a tubular shape with each other, and a proximal end (31) and a distal end (32), between which a stent lumen (34) extends. The stent surface (35) has a hydrophilic property. The molecular chemical impurities originating in the atmosphere, primarily hydrocarbon compounds, are significantly reduced on the surface by a treatment, whereby the contact angle as a measure of the hydrophilicity of a water drop present on the surface (35) is reduced in proportion to the contact angle prior to said treatment. The stent (3) is stored in an inert manner in the packaging (1).

Abstract: An allergy emergency kit (AEK) for use in treating urgent allergic reactions in common areas for allergens to exist. Generally speaking, the kit comprises a container for securing allergy medicines, a customizable panel for fastening allergy medicine in an orderly fashion, at least anaphylaxis device fastened to the panel and positioned within the container, and an instruction sheet positioned within the container and listing urgent care details for victims of allergens. Preferably, the anaphylaxis device includes at least one of either an adult-dosed and a child-dosed anaphylaxis device such as an EpiPen or similar epinephrine injection device. The allergy emergency kit may also contain auxiliary allergy medicine, such as diphenhydramine hydrochloride, antihistamine, anti-inflammatory, anti-itch, pain relief, mild sedative, asthma inhaler, ipecac, anti-nausea medicines and other such medicines, herbs or remedies which might be useful in treating the symptoms of an allergic reaction.

Abstract: A plastic package for hydrophilic articles, in particular for hydrophilically coated medical instruments, is intended to ensure the hydrophilic nature of the enclosed instrument over a long period of time. The package comprises at least one receiving compartment with a medical instrument for insertion into body tissue and is characterized in that, after sterilization by radiation, it has a proportion of volatile constituents of ?0.1 ?g/cm2.

Abstract: A plastic container containing a pharmaceutical composition comprising benzoic acid or a derivative or a pharmaceutically acceptable salt thereof and a COX-inhibitor of the oxicam-type or a pharmaceutical acceptable salt thereof, wherein the container material selected from one or more members of the group consisting of a homopolymer of polypropylene (PP), a copolymer of polypropylene (PP), a homopolymer of polyethylene terephthalate (PET) and a copolymer of polyethylene terephthalate (PET), and optionally one or more non-polymeric components.

Abstract: A device including: a bag, a tube section having a wall defining a free longitudinal space, and a plastic connector, which are all fused together, the wall including a contact layer made of a material other than PVC, selected from PE, EVA, PP, ETFE, and PVDF, and a functional layer including at least one basic functional layer of a material selected for the function thereof (flexibility, sturdiness, handling, opacity or transparence, gas barrier) and selected from the family including PE, PET, a PA, EVA, EVOH, SEBS, PETG, and PVDF, a bag, another tube section, and/or a connector fused to the biopharmaceutical tube and including a contact layer made of a material capable of being in contact with the biopharmaceutical material, which is capable of being fused onto itself, and which is identical or similar to the material of the contact layer of the biopharmaceutical tube.

Abstract: A catheter assembly is disclosed, comprising a catheter and an elongate package accommodating said catheter in a closed condition. The package is provided with an insert opening arranged to releasably receive an end of the elongate package in the closed condition, thereby temporarily retaining said closed package in a folded disposition in which also the catheter is folded.

Abstract: A catheter assembly includes a catheter, preferably having a hydrophilic surface coating; and a package accommodating said catheter. The package preferably also accommodates a wetting fluid. The package includes a first and a second sheet material connected around the edges; a perforation line extending along a non-closed loop in one of said sheet materials, which defines a flap opening; a third sheet material connected by means of an adhesive over said flap opening. The third sheet material with a margin covers the entire flap opening. The adhesive is adapted to maintain a sterile closure of the package before use, and to be resealable after use. The third sheet material forms a tab not provided with adhesive and the tab provides a grip portion for peel opening of the package.

Abstract: A neutral field tray includes a base with a width that tapers from a proximal end to a distal end, and an instrument trough at least partially recessed relative to the base and sized and configured to support at most a single surgical instrument. The trough is obliquely oriented relative to the base so as to present the proximal end of the instrument substantially above the base and to shield a sharp of the instrument within the trough. The tray also includes supporting structure for supporting the tray relative to a supporting surface.

Abstract: A system comprising a nebulizer, in particular inhaler, having a pre-installed container is proposed. The system comprises a packaging preventing fluidic connection or opening of the container in a delivery state of the nebulizer.

Abstract: The disclosure pertains to a vessel for holding replacement heart valves and associated positioning and installation apparatus which is configured and adapted to contain a biocidal sterilization fluid during and following exposure of a delivery system for the replacement heart valve to sterilization by ionizing radiation and methods of use therefor. The vessel includes a shield which limits exposure of biologically derived material therein to radiation. The vessel also provides a storage and shipping container for the replacement heart valve in which the biologically derived material is maintained in a sterile fluid environment.

Abstract: A syringe assembly including a plunger rod separate and detached from a syringe barrel and a packaging member, the plunger rod having a sealing member and the packaging member having a first compartment and a second compartment is disclosed. With the syringe barrel received within the first compartment and the plunger rod received within the second compartment, the sealing member of the plunger rod seals the syringe barrel and the plunger rod within the packaging member. In this manner, the syringe assembly is placed in the packaging member in a manner that allows for reduced storage space of the syringe assembly. In one embodiment, the syringe assembly includes an engagement portion connected to the plunger rod and a stopper slidably disposed within the interior of the syringe barrel, the engagement portion operable to secure the plunger rod to the stopper.

Abstract: A package for pharmaceutical products, in particular for parenteral products (prefilled syringes, flacons, ampoules, vials, bottles), comprises a supporting body forming at least one compartment for containing a parenteral product made from a single-sheet blank, preferably made of paper-based material, which has a base face, an upper face and a plurality of lateral faces which are connected to the base face and/or to the upper face, said upper face having at least one opening made in it and comprising at least one foldable portion defined by cutting lines of the upper face and/or by crease lines and delimiting a portion of the opening to form a cavity designed to receive the parenteral product, the supporting body being able to switch between a non-operating condition in which it has a planar profile which minimises its dimensions, and an operating condition in which: the supporting body is substantially box-shaped; the foldable portion is folded inside the supporting body so that together with the opening it

Abstract: A stand for use with a syringe is structured to engage a portion of the syringe in order to maintain the syringe in an upright position. The stand may include an aperture structured to engage the nozzle or the plunger of the syringe. Another embodiment of the stand may include a protrusion structured to engage the proximal end of the syringe, or a clip structured to engage a handle of the syringe. The stand may include a package portion having compartments for holding various components, such as components of a bone cement preparation kit. The proximal and distal portions of the barrel of the syringe may be separable to provide an opening into the barrel through which an injectable material may be inserted. The plunger of the syringe may also include a plunger rod removably affixed to the plunger tip.

Abstract: A medical organizer provides a professional, such as an anesthetist, quick access to the various items needed during a medical procedure without the need to turn away from the procedure. The organizer is formed of main housing that stabilizes various lines, such as circuit lines, IV lines, suction line etc., and also holds narcotics locked until needed. A secondary housing is removably held within the main housing and holds various implements such as catheters, swabs, alcohol, syringes and vials, waste receptacles, gauze, etc. The main housing can be secured to an IV post or operating room bed rail with the secondary housing held therein, or the secondary housing can be deployed and secured separately.

Abstract: A method of treatment and a package that is designed to accomplish this. The package provides the pet owner with a pack containing individual doses of topically applied medications pre-packaged with an oral taste treat. The topically applied medication contains at least one pharmaceutically active ingredient selected from the group of chemical families comprising phenylpyrazoles, macrocyclic lactones, neonicotinoids, synthetic pyrethroids, insect growth regulators, amidines, semicarbazones, spinosyns, octadepsipeptides, and pyrazinoisoquinolines, or any combination thereof. The treat can be administered either before the topically applied treatment is given so as to relax and distract the pet, or after the treatment is given so as to reward the pet and help it forget the stress of treatment. The treat can also be shaped to signify the type of animal to be treated.

Abstract: The invention provides immunostimulatory compositions and methods of administration thereof. Also provided are methods of administering a tryptanthrin compound in an effective amount to enhance the immune response of a subject to an antigen. Also provided are methods of administering an effective amount of a tryptanthrin to stimulate the immune response in a subject for the treatment of cancer. Further provided are methods of administering a tryptanthrin compounds as an immunotherapeutic in the treatment of infectious diseases.

Abstract: The present invention provides compositions comprising isolated human collagen, isolated human elastin and a pharmaceutically acceptable carrier wherein the human elastin is substantially insoluble in water with a molecular weight greater than 100 kDa. The present invention further provides methods and kits for soft tissue augmentation.

Abstract: Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.