Medicinal Content Patents (Class 206/828)
  • Patent number: 11857496
    Abstract: A temperature-controlled shipper for shipping diagnostic blood samples is disclosed. The shipper must remain at a temperature between 6° C. and 37° C. for up to 24 hours while in transit. The shipper includes identical mating PCM blow-molded bottles which enclose and protect diagnostic blood sample vials. Identical mating clamshell insulating containers further enclose and protect the PCM bottles. Both the bottles and clamshell containers can be re-used. A dual PCM liquid suspension is utilized in the PCM bottles and is preconditioned and stored at a single temperature.
    Type: Grant
    Filed: February 20, 2021
    Date of Patent: January 2, 2024
    Assignee: Packaging Technology Group, LLC
    Inventors: William C. Blezard, Muhammad Kashif Azeem
  • Patent number: 11851259
    Abstract: The present apparatus and system relate to a structure for housing and containing products together and protecting products within a container from agitation and blunt force trauma. A resilient plug is adapted to fit within a container and contact a product housed within the container. When the container exhibits forces from movement, the plug dampens the impact of the movement by steadying the product within the container. Multiple containers may be mixed and matched and held together with a bundler that allows for easy insertion of the containers into the bundler but more difficult removal from the bundler.
    Type: Grant
    Filed: December 20, 2021
    Date of Patent: December 26, 2023
    Inventors: Travis Honda, Robert Speerstra
  • Patent number: 11505382
    Abstract: A multi-unit packing system includes a packaging tray assembly supporting a medical device or product. The packaging tray assembly includes a tray that holds the medical product within a spring-loaded card. The spring-loaded card being disposed within the inner container of the tray. The spring-loaded card including a one or more openings that are positioned to maintain the medical product in a defined orientation while preventing the inadvertent movement of the medical product. The spring-loaded card comprises elastic properties to allow it to be elastically compressed when the barrier is sealed to the tray, and uncompressed when the barrier is peeled away from the tray, allowing a portion of the spring-loaded card to extend beyond a surface of the tray to provide easier access, removal and transfer of the sterile medical product within the sterile field.
    Type: Grant
    Filed: July 27, 2021
    Date of Patent: November 22, 2022
    Assignee: Prospect Life Sciences, Inc.
    Inventors: Randall Allard, Jason Morton, Polly Allard, Tom McLeer
  • Patent number: 11273101
    Abstract: A system includes a vial access device including a vial access housing having a wall defining an elongate opening between an opening proximal end and an opening distal end, the vial access housing including a spike and a vial connection element attachable to a first vial defining a first vial size to secure the vial access device to the first vial, and an adapter movable within the elongate opening of the vial access housing. The adapter is transitionable between a first position where the adapter is adjacent the opening distal end of the vial access housing and the adapter is attachable to a second vial defining a second vial size and a second position where the adapter is adjacent the opening proximal end of the vial access housing and the vial connection element of the vial access device is attachable to the first vial.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: March 15, 2022
    Assignee: Becton Dickinson and Company Limited
    Inventors: Ross Weir, Lasse Wesseltoft Mogensen
  • Patent number: 10391031
    Abstract: A system (10) includes a vial access device (12) including a spike (38), with the vial access device attachable to a first vial (80) defining a first vial size (81), and an adapter (14) transitionable between a shield position in which the adapter is attachable to the vial access device such that the adapter shields the spike of the vial access device and a vial position in which the adapter is attachable to a second vial (90) defining a second vial size (91), the second vial size different than the first vial size.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: August 27, 2019
    Assignee: Becton Diskinson and Company Limited
    Inventors: Yan Yevmenenko, Ross Weir, Lasse Wesseltoft Mogensen
  • Patent number: 10219982
    Abstract: A system includes a vial access device including a vial access housing having a wall defining an elongate opening between an opening proximal end and an opening distal end, the vial access housing including a spike and a vial connection element attachable to a first vial defining a first vial size to secure the vial access device to the first vial, and an adapter movable within the elongate opening of the vial access housing. The adapter is transitionable between a first position where the adapter is adjacent the opening distal end of the vial access housing and the adapter is attachable to a second vial defining a second vial size and a second position where the adapter is adjacent the opening proximal end of the vial access housing and the vial connection element of the vial access device is attachable to the first vial.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: March 5, 2019
    Assignee: Becton Dickinson and Company Limited
    Inventors: Ross Weir, Lasse Wesseltoft Mogensen
  • Patent number: 9717843
    Abstract: A system and method are provided for packaging and sterilizing analyte sensors. The packaging system provides a structure for securing the analyte sensors in a fixed position and fixed orientation within the package.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: August 1, 2017
    Assignee: DexCom, Inc.
    Inventors: Minda McDorman Grucela, Jinsong Gao
  • Patent number: 8720679
    Abstract: A container for an orally ingested pharmaceutical composition has, in a container body, a pharmaceutical composition chamber, a chamber for an auxiliary substance for the pharmaceutical composition chamber, and a chamber for the auxiliary substance for a cap. The container for an orally ingested pharmaceutical composition is provided with said cap in addition to a container body. An inter-chamber portion seals the pharmaceutical composition chamber from the chamber for the auxiliary substance for the chamber. A boundary portion seals the chamber for the cap auxiliary substance from the inside of the cap. By the inter-chamber portion and the boundary portion being bent, one end of the container body is removably inserted into the cap.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: May 13, 2014
    Assignee: Morimoto-Pharma Co., Ltd.
    Inventors: Shuji Morimoto, Yutaka Sakuma
  • Patent number: 8627972
    Abstract: A sterile container having a lower container part and an upper container part for closing the lower container part is provided. The lower and upper container parts define, in a closed position, a container interior. A sealing device is provided for gastight sealing of the sterile container in the closed position. The sealing device comprises a circumferential sealing element bearing against both the lower and upper container parts in the closed position. The sealing element comprises an upper container part sealing section with an upper container part sealing surface region bearing against the upper container part, and a lower container part sealing section with a lower container part sealing surface region bearing against the lower container part. The sealing device further comprises a pretensioning device for exerting a pretensioning force on at least the lower container part sealing section or on the upper container part sealing section.
    Type: Grant
    Filed: July 7, 2011
    Date of Patent: January 14, 2014
    Assignee: Aesculap AG
    Inventor: Stefan Thomas
  • Patent number: 8617125
    Abstract: A medical delivery system wherein one of a container and a dosing assembly comprises a first fastening means (116) and the other one of the container and the dosing assembly comprises a second fastening means (114); and wherein the second fastening means is adapted to move at least a part of the first fastening means in a radial direction upon rotation of the container in a first rotational direction relative to the dosing assembly, whereby the first and second fastening means engage such that the container and the dosing assembly are locked for relative translational movement. A container and a dosing assembly for use in the medical delivery system.
    Type: Grant
    Filed: December 15, 2007
    Date of Patent: December 31, 2013
    Assignee: Novo Nordisk A/S
    Inventor: Asger Voss Christiansen
  • Patent number: 8609043
    Abstract: The present invention relates to the use of a container, made of an inorganic additive containing plastic material, for reducing physical/chemical interaction between the container and an oil, fat and/or wax containing formulation contained therein.
    Type: Grant
    Filed: August 6, 2012
    Date of Patent: December 17, 2013
    Assignee: M & P Patent Aktiengesellschaft
    Inventor: Claudia Mattern
  • Patent number: 8579137
    Abstract: In the case of a packaging unit comprising a plastic bottle (2) with a flexible foil bag (3) arranged therein, wherein a hollow interspace (5) is formed at least in certain regions between the surface of the inner wall of the plastic bottle (2) and the outer surface of the foil bag (3), the foil bag (3) is designed such that it at least partially automatically elastically contracts and/or can be compressed at least in certain regions by a force effected by a means arranged in the interspace (5) and/or can be collapsed.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: November 12, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stefan Lustenberger, Stephan Kurtze
  • Patent number: 8382728
    Abstract: An emergency medication storage and integrated single use device for providing oral dissolving medications strips in a convenient transparent transfer environment. A thin card size dispenser holds a single medicated strip in user access orientation positioned for direct card insertion to the user's mouth assuring proper dispensing of the medication in an emergency situation.
    Type: Grant
    Filed: May 16, 2011
    Date of Patent: February 26, 2013
    Inventor: Sam Gibson
  • Patent number: 8114061
    Abstract: A welding boat for a pouch has a center part and two prolongations extending therefrom in opposite directions and tapering acutely. The welding boat has an opening for the filling of the pouch with a substance in manufacture and inlets and outlets for the actual use of the pouch. The center part is substantially filled by an opening with a lumen which is as large as possible and preferably circular, and the side edges of the side prolongations contact the opening tangentially.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: February 14, 2012
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Matthias Brandl, Peter Hilgers, Franz Kugelmann, Matthias Meisinger
  • Patent number: 8074817
    Abstract: A method and apparatus for metering a liquid nutritional supplement is disclosed and provides a liquid dispenser having a body that contains a predetermined number of single dosages of the liquid nutritional supplement, a cap, such as a child resistant cap, coupled to a neck portion of the body, and a dosage cup coupled to the cap. The dosage cup has at least four axial shoulders on an inside surface thereof wherein each has an engaging surface adapted to engage axial ridges of the cap. The dosage cup is coupled to the cap such that a force that is greater, by a predetermined amount, than the weight of the dosage cup is required to remove the dosage cup from the cap. The dosage cup is provided with an indicator adapted to indicate one of the single dosages of the liquid nutritional supplement to be consumed by a user for a predetermined time period.
    Type: Grant
    Filed: October 10, 2007
    Date of Patent: December 13, 2011
    Assignee: Remington Health Products, L.L.C.
    Inventors: William E. Steele, IV, Phillip D. Livingston, Clarence D. Zierhut
  • Patent number: 8047374
    Abstract: A back support has front, rear, bottom, top and side edges. A box has a rear face formed coextensive with the back support, a front face, a bottom face, and side faces. A rectilinear chamber is formed by the front, rear, bottom and side faces of the box and has an open top for receiving and supporting medication containers on the bottom face of the box for easy access and removal. The chamber is formed with vertically oriented recesses on the front and rear faces of the box. A plurality of rectangular divider panels with edges removably received within the recesses divide the chamber into sections adapted to separate the containers received and supported in the chamber. The panels are repositionable as a function of the size and number of the containers within the chamber.
    Type: Grant
    Filed: November 13, 2009
    Date of Patent: November 1, 2011
    Inventors: Robert G. Heinzler, John F. Lovely
  • Patent number: 7972558
    Abstract: A method and an apparatus for sterilizing packaging material for use in packaging for protein containing products, such as food products or medical drugs. The packaging material is sterilized by irradiating it using a beam of ionizing radiation, such as an electron beam or a beam of gamma rays. Afterwards, the packaging material is processed in such a manner that protein reactive substances or compounds formed in the packaging material during the irradiation step are at least partly removed or rendered inreactive with respect to proteins. The processing step may advantageously be performed by heating the packaging material. Preferably, the processing step involves accelerating diffusion from the packaging material of protein reactive substances or compounds. Since the protein reactive substances or compounds are removed or rendered inreactive with respect to proteins, degradation of the product which is later stored in the packaging material is considerably reduced.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: July 5, 2011
    Assignee: Novo Nordisk A/S
    Inventors: Lasse Hansen, Anders Dossing Norskov, Per Jeppensen, Signe Agnete Christensen
  • Patent number: 7807242
    Abstract: A container consisting of a PCTFE monolayer, the thickness of said layer being about 40-100 ?m, which container is equipped with a device where the liquid can be lead out through when desired and which container is transparent, shows superior properties for storing liquid pharmaceutical compositions, especially insulin compositions containing preservatives.
    Type: Grant
    Filed: June 22, 2006
    Date of Patent: October 5, 2010
    Assignee: Novo Nordisk A/S
    Inventors: Anne Soerensen, Philip Albert Sparholt, Marianne Rye Hansen
  • Patent number: 7658279
    Abstract: A medical multi-chamber container (1) comprising a container body (3) having first and second chambers (10, 11) for storing medicaments, a weak partition seal (20) for portioning the charmers (10, 11) from each other, and an outlet (32) fitted into the container body (3) for allowing the medicaments to be delivered from the second chamber (11), the container body (3) further comprising a weak discharge seal (21) partitioning the second chamber (11) from the outlet (32) and unsealably formed so as to allow the chambers (10, 11) to communicate with each other when used, characterized in that the unsealing strength of the weak discharge seal (21) is less than that of the weak partition seal (20).
    Type: Grant
    Filed: January 8, 2003
    Date of Patent: February 9, 2010
    Assignee: Otsuka Pharmaceutical Factory Inc.
    Inventors: Minoru Oka, Masaru Ohnishi, Shin Hamazaki, Osamu Nakao, Yoshihiro Sugioka
  • Patent number: 7624869
    Abstract: A wound care package includes a wound care product for treating a severe wound and an individual package in which the wound dressing is stored prior to usage. The wound care package further includes a booklet-type label affixed to an exterior surface of the individual package, the booklet-type label including on its interior surface severe wound treatment information.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: December 1, 2009
    Assignee: Medline Industries, Inc.
    Inventor: Jonathan S. Primer
  • Patent number: 7618405
    Abstract: A flexible container incorporating flexible front and rear sheets and one or more container ports disposed in between the sheets are discussed. The one or more container ports each has a pliable attachment flange and an integrally molded nozzle. The pliable attachment flange has a first configuration whereby the attachment flange collapses to enable heat sealing the attachment flange to the sheets and thereafter substantially recovers its shape to provide a fluid pathway with the port. Various terminal ports, terminal caps, and rubber septums may be useable with the one or more container ports.
    Type: Grant
    Filed: February 4, 2008
    Date of Patent: November 17, 2009
    Assignee: B. Braun Medical Inc.
    Inventor: Harvey Theodore Young
  • Patent number: 7604124
    Abstract: A container for storing and dispensing pelletized products includes an elongate hollow tube, an exterior panel integrally tangentially extending from the tube and dosage period indicia on the panel adjacent to the tube. Spacings between the dosage period indicia on the panel preferably are coordinated with a predetermined size of the pelletized products within the tube such that a dosage period indicium is disposed adjacent to each pelletized product in the tube when the tube is full. The dosage period indicia can be molded, printed or labeled on the panel. The dosage period indicia preferably are days of the week, and multiple containers, preferably four containers, can be assembled in a package for sale to a consumer.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: October 20, 2009
    Assignee: Rexam Healthcare Packaging Inc.
    Inventor: John M. Shingle
  • Patent number: 7513367
    Abstract: Provided as a drug dispensing system comprising a cabinet and at least one cartridge. A cabinet has opposing door portions which are hingedly attached to one another and which are configured to be closable against one another such as via a lock member. Each one of the door portions includes at least one shelf which defines a shelf depth and which has an upwardly turned lip extending along the length of the shelf. The cartridge has a cartridge depth that is sized to be complementary to the shelf depth such that the cartridge may be retained by the lip when the cartridge is stored on the shelf. Each one of the cartridges is configured to store a plurality of vials. A punch-out is disposed in a lower end of the cartridge and through which the vials may be dispensed from the cartridge.
    Type: Grant
    Filed: July 1, 2005
    Date of Patent: April 7, 2009
    Assignee: Dispensing Solutions, Inc.
    Inventor: Richard Wolpow
  • Patent number: 7435246
    Abstract: A system for removing or transferring a pharmaceutical product from a reservoir including an ampoule with a moveable piston therein and an adaptor which includes, generally along a longitudinal axis, a reservoir connector and an ampoule connector for coupling to the ampoule, wherein the ampoule connector includes at least one locking mechanism which, in a side wall, includes a resilient element generally corresponding to a portion of the side wall which extends along the periphery thereof and, at opposing ends, merges with the side wall.
    Type: Grant
    Filed: February 15, 2007
    Date of Patent: October 14, 2008
    Assignee: Disetronic Licensing AG
    Inventor: Rudolf Zihlmann
  • Patent number: 7387646
    Abstract: The present invention relates to a method of protecting organic material, especially from the pharmaceutical, food and nutrition sectors, from light, which method comprises applying to or incorporating in a carrier material a combination of the dye of formula (1) the dye of formula (2) and a UV absorber and, optionally, further dyes, and positioning the so-treated carrier material between the light source and the organic material to be protected
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: June 17, 2008
    Assignee: Ciba Specialty Chemicals Corporation
    Inventor: Joachim Jandke
  • Patent number: 7328802
    Abstract: A child resistant blister package includes a film having a surface wherein a plurality of cavities are formed therein containing at least one medicament; a cover sheet which overlies the cavities and is bonded to the film; and a wall structure raised above the surface of the film which extends throughout the film forming an interior region enclosing the plurality of cavities therein.
    Type: Grant
    Filed: December 6, 2005
    Date of Patent: February 12, 2008
    Assignee: SmithKline Beecham Corporation
    Inventor: Fred Mieras Killinger
  • Patent number: 7322969
    Abstract: A liquid-medicine injection port device includes: a liquid-medicine inlet which is formed at its upper end; a liquid-medicine outlet which is formed at its lower end which is connectable to a liquid-medicine container; a liquid passageway which connects the liquid-medicine inlet and the liquid-medicine outlet; a germ-removal filter which is provided in the liquid passageway; and a closure which closes the liquid passageway downstream from the germ-removal filter and opens it easily. Further, a liquid-medicine container is provided with this liquid-medicine injection port device. Or further, the liquid-medicine container has a two-chamber structure in which an injection chamber provided with the liquid-medicine injection port device which the germ-removal filter is attached to, and a storage chamber storing a liquid medicine are divided by a weak seal portion having such a strength that it is easily peeled.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: January 29, 2008
    Assignee: Nipro Corporation
    Inventors: Hiroyuki Hattori, Takamitsu Ohkawara, Atsushi Ishikawa
  • Patent number: 7296700
    Abstract: A method and apparatus for metering a liquid nutritional supplement provides a liquid dispenser having a body that contains a predetermined number of single dosages of the liquid nutritional supplement, a cap, such as a child-resistant cap, coupled to a neck portion of the body, and a dosage cup coupled to the cap. The dosage cup has at least four axial shoulders on an inside surface thereof that each has an engaging surface adapted to engage axial ridges of the cap. The dosage cup is coupled to the cap such that a force that is greater, by a predetermined amount, than the weight of the dosage cup is required to remove the dosage cup from the cap, and providing the dosage cup with an indicator adapted to indicate one of the single dosages of the liquid nutritional supplement to be consumed by a user for a predetermined time period.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: November 20, 2007
    Assignee: Remington Health Products, L.L.C.
    Inventors: William E. Steele, IV, Phillip D. Livingston, Clarence D. Zierhut
  • Patent number: 7100600
    Abstract: A fluid filled ampoule comprises an ampoule body having a top end, a bottom end and a sealed interior containing a liquid. A top tab is coupled to the top end and is removable to create a drain vent in the top end. A bottom tab is coupled to the bottom end and is removable to create a drain opening in the bottom end. A movable shroud is coupled to the top end and is disposed about the top tab. The shroud is movable to permit access to the top tab.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: September 5, 2006
    Assignee: Aerogen, Inc.
    Inventors: Joseph P. Loeffler, Richard Q. Poynter, David Rapp, Michael Klimowicz
  • Patent number: 7041664
    Abstract: Disclosed are compounds of the formula: or pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof, wherein R1, R2, R3, X, Q1 and Q2 are defined herein, which compounds are ligands for neurokinin receptors, in particular NK-3 receptors, and are therefor useful in the treatment of a wide range of diseases or disorders including, but not limited to depression, anxiety, psychosis, obesity, pain, Parkinson's disease, Alzheimer's disease, neurodegenerative diseases, movement disorders, respiratory diseases, inflammatory diseases, neuropathy, immune disorders, migraine, biliary disfunction, and dermatitis.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 9, 2006
    Assignee: Neurogen Corporation
    Inventors: Jun Yuan, George Maynard, Alan Hutchison
  • Patent number: 7000769
    Abstract: A child resistant blister package includes a film having a surface wherein a plurality of cavities are formed therein containing at least one medicament; a cover sheet which overlies the cavities and is bonded to the film; and a wall structure raised above the surface of the film which extends throughout the film forming an interior region enclosing the plurality of cavities therein.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: February 21, 2006
    Assignee: Smithkline Beecham Corporation
    Inventor: Fred Mieras Killinger
  • Patent number: 6997917
    Abstract: A vial having a V-shaped bottom to minimize the amount of medical fluid left in the vial at the end of the fluid withdrawal process. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends into the V-shaped bottom. The vial access adapter may be vented or non-vented. When the medical fluid is a nuclear drug, the vial and vial access adapter is enshrouded in a protective container containing lead to provide a safety to medical personnel from irradiation.
    Type: Grant
    Filed: October 5, 2004
    Date of Patent: February 14, 2006
    Assignee: Bracco Diagnostics, Inc.
    Inventors: John J. Niedospial, Jr., Jason M. Voytilla
  • Patent number: 6992087
    Abstract: Substituted aryl 1,4-pyrazine derivatives of formula I as defined herein and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: January 31, 2006
    Assignee: Pfizer Inc
    Inventors: Patrick R. Verhoest, Robert Louis Hoffman, Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu
  • Patent number: 6974447
    Abstract: The present invention provides a receptacle for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube is sealed in the seal having a proximal end in the receptacle, a distal end accessible from outside the receptacle, a flow passage extending between said proximal and distal ends, and a closure blocking flow through the flow passage adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube and closure are essentially impermeable to said gas.
    Type: Grant
    Filed: April 16, 2002
    Date of Patent: December 13, 2005
    Assignees: Baxter International Inc., Baxter Healthcare S.A.
    Inventors: Sidney T. Smith, Larry Rosenbaum, Gregg Nebgen, William S. Hurst, William S. Hoerle, Adel M. Sadik, Melissa J. Skelnik, Steven H. Giovanetto, Bradley Buchanan
  • Patent number: 6964965
    Abstract: The present invention provides substituted pyrazine derivatives of Formula I, that are CRF1 receptor antagonists, including human CRF1 receptors. This invention also relates to use of compounds of the invention for treating a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders, particularly anxiety-related disorders and mood disorders.
    Type: Grant
    Filed: April 17, 2003
    Date of Patent: November 15, 2005
    Assignee: Pharmacia & Upjohn
    Inventors: Jeffrey W. Corbett, Michael Dalton Ennis, Kristine E. Frank, Jian-Min Fu, Robert Louis Hoffman, Patrick R. Verhoest
  • Patent number: 6948491
    Abstract: A feed system for an aerosolizer utilizes an ampoule containing a liquid and includes a housing having an ampoule region into which the ampoule is held, and a liquid receiving region that is adapted to receive liquid dispensed from the ampoule. An interface is used to couple the liquid receiving region to an aerosol generator, whereby liquid from the liquid receiving region is permitted to flow to the aerosol generator for aerosolization.
    Type: Grant
    Filed: March 20, 2001
    Date of Patent: September 27, 2005
    Assignee: Aerogen, Inc.
    Inventors: Joseph P. Loeffler, David Rapp, Victor Briones, Ralf Bitdinger, Michael Klimowicz
  • Patent number: 6946469
    Abstract: The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, wherein A is selected from NCN, NCONH2, and NOR9. The present invention relates to compounds which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: September 20, 2005
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventors: Jeffery W. Corbett, James David Rodgers
  • Patent number: 6882738
    Abstract: A tangible object (such as a microprocessor, wristwatch, pharmaceutical, compact disc, vehicle part, etc) is surface-textured to encode a plural-bit code thereon. In one arrangement, this encoding conveys date information. In use, the object can be imaged by a scanner apparatus, and the resulting scan data analyzed to discern the plural-bit code. The decoded date information can be used in a determination relating to the object. For example, at a port of entry, date information encoded on a Rolex wristwatch can be used to determine whether importation of the wristwatch should be permitted. The texture-encoded data can also convey other information, such as a vehicle identifier for an automotive part, a place of fabrication, a specification with which the part complies, etc.
    Type: Grant
    Filed: October 23, 2003
    Date of Patent: April 19, 2005
    Assignee: Digimarc Corporation
    Inventors: Bruce L. Davis, Geoffrey B. Rhoads
  • Patent number: 6875205
    Abstract: A vial adapter having a needle-free valve, a sharpened cannula used to perforate a vial's rubber stopper, and a circular array of claws of different lengths to engage vial closures of different diameters. The array of claws includes a first set of claws each having a first length extending inwardly from the periphery of the housing of the adapter and a second set of claws alternating with the first set of claws and each having a longer length. The second set of claws are mounted so that they deflect and plastically deform out of the way in the case where the adapter is engaged with a vial that exceeds a predetermined size. The housing includes a shroud that is at least as long as the sharpened cannula to protect medical personnel who use the adapter from inadvertent punctures. The needle-free valve includes a resiliently deformable piston element with a naturally open bore. The interior of the piston provides a fluid flow path through the adapter.
    Type: Grant
    Filed: February 8, 2002
    Date of Patent: April 5, 2005
    Assignee: Alaris Medical Systems, Inc.
    Inventor: Karl R. Leinsing
  • Patent number: 6773427
    Abstract: An infusion container comprising a communication port capable of being connected with a syringe, a container main body, a communication channel for providing communication between the inside of the container main body and the inner lumen of the communication port, and a sterilization filter provided in the communication channel, wherein the communication port is closed with a rubber stopper provided with a slit allowing the top end tip of the syringe to pass therethrough and the communication channel is closed with a closing means capable of being easily opened.
    Type: Grant
    Filed: January 31, 2002
    Date of Patent: August 10, 2004
    Assignee: Nipro Corporation
    Inventor: Nobuo Takagi
  • Patent number: 6764482
    Abstract: A dual-filled twin bag, a packaging including the twin bag, and a method for forming the packaged twin bags are provided. Each of two bags, a solution bag (10) and a drain bag (12) for a system used for a peritoneal dialysis procedure, are filled, at least partially, with a solution (14). A tubing set (16) connects the two filled bags (10,12) and may also be filled with solution (14) which is added to the bags (10,12) and the tubing set (16) during the manufacturing process. Alternatively, the tubing set (16) may be filled with air. The tubing set (16) is sandwiched between the solution bag (10) and the drain bag (12) and subsequently packaged in an overpouch (24). The method for forming the package including the bags filled with solution is simplified and the overall package size is reduced due to the sandwiched tubing set (16) between the solution bags (10,12) and the provision of solution in both bags (10,12).
    Type: Grant
    Filed: October 29, 2002
    Date of Patent: July 20, 2004
    Assignee: Baxter International Inc.
    Inventors: Michael R. Keilman, Walter A. Makaryk, Joseph A. Giertych
  • Publication number: 20040078023
    Abstract: The present invention provides a peelable seal for a multi-chambered container including a first edge and a second edge. At least one of the first edge or second edge includes a stress bearing portion and a non-stress bearing portion.
    Type: Application
    Filed: October 17, 2002
    Publication date: April 22, 2004
    Inventors: Paul-Andre Gollier, Patrick Balteau, Vincent Houwaert, Francesco Peluso
  • Publication number: 20040078021
    Abstract: A method and apparatus are provided by which a fluid may be drawn and packaged within a series of interconnected sterile units. Once filled with the fluid, the connectors joining the sterile units may be sealed and severed to produce a number of separate sterile units. The volume of the separate sterile units may correspond to a single dose of the fluid. The technique allows a fluid to be partitioned into sterile units without exposure to the air or other potential contaminants.
    Type: Application
    Filed: October 17, 2002
    Publication date: April 22, 2004
    Inventor: Richard W. Yee
  • Publication number: 20040078022
    Abstract: Containers and conduits comprising a copolymer comprising ethylene and an acrylate are disclosed.
    Type: Application
    Filed: August 13, 2003
    Publication date: April 22, 2004
    Inventor: Michael Donart
  • Patent number: 6708822
    Abstract: The invention provides compositions and methods for the convenient compounding of pharmaceuticals. Single and multiple unit of use kits are provided which contain all the necessary components required for preparing a compounded pharmaceutical.
    Type: Grant
    Filed: November 7, 2000
    Date of Patent: March 23, 2004
    Assignee: CutisPharma, Inc.
    Inventor: Indu A. Muni
  • Patent number: 6695829
    Abstract: A container closure system for delivering a fluid. The system includes a stopper constructed to seal fluidly a container. A closure member is mounted on an upper surface of the stopper. The closure member includes a base having an upper surface and a lower surface. The closure member further includes an outer wall and an inner wall extending from the upper surface of the base with the inner wall spaced from the outer wall. The base defines therethrough a needle access port between the inner and outer walls. The inner wall defines a chamber therein. The base further defines therethrough an aperture adjacent the chamber defined by the inner wall. A piercing member is movably disposed within the chamber defined by the inner wall. The piercing member has a first end portion and a second end portion, the first end portion being positioned proximally to the stopper. A piercing tip is mounted on the first end portion and is constructed to pierce the stopper.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: February 24, 2004
    Assignee: Abbott Laboratories
    Inventors: Steven P. Hellstrom, Peter J. Karas, John C. Tanner, II
  • Patent number: 6659282
    Abstract: Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: December 9, 2003
    Assignee: Brigham and Women's Hospital
    Inventor: Charles N. Serhan
  • Patent number: 6637431
    Abstract: The present invention relates to a blister pack (12) having a plurality of blisters (13) each holding a dose of a powdered medicament comprising a lower base (18) containing a plurality of cavities (19) for the powdered medicament and an upper sealing foil layer (20) which covers the lower base (18) to form the blisters (13). Each cavity (19) is provided with at least one adjacent slit (21) formed by scoring the foil layer (20) and a lower base (18). The slit (21) ensuring accurate penetration of a cavity (19) by a suction tube through which a user can inhale the contents of the cavity (19).
    Type: Grant
    Filed: April 24, 2001
    Date of Patent: October 28, 2003
    Assignee: AstraZeneca AB
    Inventors: Carina Ekelius, Per-Åke Ohlsson, Anders Selmer
  • Patent number: 6629603
    Abstract: A portable gargling solution packet including a package having an interior and an openable upper end. The interior is defined by opposed side walls. A saline solution is disposed within the interior of the package. A heat producing chemical lining is disposed within at least one of the opposed side walls of the package. When the openable upper end is opened the heat producing chemical lining reacts to outside air to cause an exothermic reaction to heat the saline solution.
    Type: Grant
    Filed: November 24, 2001
    Date of Patent: October 7, 2003
    Inventor: Edwina K. Fontaine
  • Patent number: 6619494
    Abstract: A package for tablet products that includes a container having an interior volume for holding the tablet products and a closure secured to a cylindrical finish of the container. A product hold-down device has an axially resilient central portion, a lower portion for engaging the upper surface of the product within the container, and an upper portion for securement within the container finish to hold the device in place within the finish, with the closure removed from the finish, against the axially resilient forces applied to the device by engagement of the lower portion with product in the container and resilient compression of the central portion of the device. Thus, the hold-down device can be inserted into the container and secured to the container using automatic packaging equipment, and the container closure then applied to the container. In use, the closure is removed from the container, and the device is removed and discarded by the user.
    Type: Grant
    Filed: March 11, 2002
    Date of Patent: September 16, 2003
    Assignee: Owens-Illinois Closure Inc.
    Inventors: Brian J. Brozell, Stephen A. Eilertson